Circulation: Heart Failure HHF Alcohol and Incident Heart Failure Among Middle-Aged and Elderly Men: The Cohort of Swedish Men Dorans et al: Alcohol and Heart Failure Incidence CIRCHF/2014/001787 CIRCHF/2014/001787 10.1161/CIRCHEARTFAILURE.114.001787 8 05/19/15 3 Picillo Emily 617-542-5100 617-542-6539 Udelson, James Tufts Medical Center Dr. Murray A. Mittleman mmittlem@bidmc.harvard.edu Dr. Beth Israel Deaconess Medical Center Cardiovascular Epidemiology Research Unit 375 Longwood Ave Boston Massachusetts 02215 UNITED STATES 617-632-7653 617-632-7698 16655 Kirsten S. Dorans Beth Israel Deaconess Medical Center kdorans@mail.harvard.edu 238233 Elizabeth Mostofsky Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center emostofs@mail.harvard.edu 98310 Emily B. Levitan University of Alabama at Birmingham elevitan@uab.edu 21911 Niclas Håkansson Karolinska Institutet niclas.hakansson@ki.se 104224 Alicja Wolk Karolinska Institutet alicja.wolk@ki.se 56765 Murray A. Mittleman Beth Israel Deaconess Medical Center mmittlem@bidmc.harvard.edu 16655 10/02/2014 10/02/2014 03/27/2015 04/07/2015 04/14/2015 05/19/2015 Original Articles <p><b><i>Background</i></b>—Compared with no alcohol consumption, heavy alcohol intake is associated with a higher rate of heart failure (HF) whereas light-to-moderate intake may be associated with a lower rate. However, several prior studies did not exclude former drinkers, who may have changed alcohol consumption in response to diagnosis. This study aimed to investigate the association between alcohol intake and incident HF. </p><p><b><i>Methods and Results</i></b>—We conducted a prospective cohort study of 33,760 men 45-79 years old with no HF, diabetes mellitus or myocardial infarction at baseline participating in the Cohort of Swedish Men Study. We excluded former drinkers. At baseline, participants completed a food-frequency questionnaire and reported other characteristics. HF was defined as hospitalization for or death from HF, ascertained by Swedish inpatient and cause-of-death records from January 1, 1998 through December 31, 2011. We constructed Cox proportional hazards models to estimate multivariable-adjusted rate ratios (IRRs). During follow-up, 2916 men were hospitalized for (n=2139) or died (n=777) of incident HF. There was a U-shaped relationship between total alcohol intake and incident HF (p=0.0004). There was a nadir at light-to-moderate alcohol intake: consuming 7 to less than 14 standard drinks per week was associated with a 19% lower multivariable-adjusted rate of HF compared with never drinking (IRR: 0.81, 95% CI: 0.69, 0.96). </p><p><b><i>Conclusions</i></b>—In this cohort of Swedish men, there was a U-shaped relationship between alcohol consumption and HF incidence, with a nadir at light-to-moderate intake. Heavy intake did not appear protective.</p> 3 0 0 0 0 no yes CircHF_CIRCHF-2014-001787.xml CircHF_CIRCHF-2014-001787_file1.docx ClinicalPerspective_20150326.docx CircHF_CIRCHF-2014-001787_merge.pdf CircHF_CIRCHF-2014-001787_Wolk_56765_disclosure.pdf CircHF_CIRCHF-2014-001787_Wolk_56765_copyright.pdf CircHF_CIRCHF-2014-001787_Dorans_238233_disclosure.pdf CircHF_CIRCHF-2014-001787_Dorans_238233_copyright.pdf CircHF_CIRCHF-2014-001787_Mittleman_16655_disclosure.pdf CircHF_CIRCHF-2014-001787_Mittleman_16655_copyright.pdf CircHF_CIRCHF-2014-001787_Levitan_21911_disclosure.pdf CircHF_CIRCHF-2014-001787_Levitan_21911_copyright.pdf CircHF_CIRCHF-2014-001787_Mostofsky_98310_disclosure.pdf CircHF_CIRCHF-2014-001787_Mostofsky_98310_copyright.pdf CircHF_CIRCHF-2014-001787_Hkansson_104224_disclosure.pdf CircHF_CIRCHF-2014-001787_Hkansson_104224_copyright.pdf Please charge authors $70 per page MS has clinical perspective Please set the flag 'exportcadmusahafundingtypecodes' with the funding type code of the sources you wish to list. Subject Codes: [8] Epidemiology [110] Congestive epicillo