Circulation: Heart Failure HHF The Kansas City Cardiomyopathy Questionnaire Score Is Associated With Incident Heart Failure Hospitalization in Chronic Kidney Disease Patients Without Previously Diagnosed Heart Failure: The CRIC Study Mishra et al: Incident Heart Failure and CKD CIRCHF/2015/002097-A CIRCHF/2015/002097-A 10.1161/CIRCHEARTFAILURE.115.002097 8 07/21/15 4 Picillo Emily 617-542-5100 617-542-6539 Udelson, James Tufts Medical Center Dr. Michael G. Shlipak michael.shlipak@ucsf.edu Dr. University of California, San Francisco VA Medical Center, 4150 Clement Street San Francisco California 94121 UNITED STATES 415-750-2093 415-379-5573 40502 Rakesh K. Mishra University of California, San Francisco rakesh.mishra@ucsf.edu 199615 Wei Yang University of Pennsylvania weiyang@mail.med.upenn.edu 162170 Jason Roy University of Pennsylvania jaroy@mail.med.upenn.edu 212700 Amanda Hyre Anderson University of Pennsylvania andersah@mail.med.upenn.edu 109126 Nisha Bansal University of Washington nbansal@uw.edu 165101 Jing Chen Tulane University School of Medicine jchen@tulane.edu 20601 Christopher DeFilippi University of Maryland School of Medicine cdefilip@medicine.umaryland.edu 16919 Patrice Delafontaine University of MO-School of Medicine pdelafon@tulane.edu 3071 Harold I. Feldman University of Pennsylvania hfeldman@mail.med.upenn.edu 168430 Radhakrishna Reddy Kallem University of Pennsylvania krishna.kallem@uphs.upenn.edu 41462 John W Kusek NIDDK kusekj@extra.niddk.nih.gov 85135 Claudia M. Lora University of Illinois clora1@uic.edu 215874 Sylvia E. Rosas Joslin Diabetes Center Sylvia.rosas@joslin.harvard.edu 21288 Alan S. Go Kaiser Permanente Northern California alan.s.go@kp.org 53711 Michael G. Shlipak University of California, San Francisco michael.shlipak@ucsf.edu 40502 05/21/2014 05/21/2014 05/04/2015 05/15/2015 05/18/2015 07/21/2015 Original Articles Kansas City Cardiomyopathy Questionnaire CIRCHF/2014/001473R1 Symptoms Characteristic of Heart Failure Are Associated with Incident Heart Failure in Chronic Kidney Disease Patients: The CRIC Study. <p><b><i>Background</i></b>—Chronic kidney disease (CKD) is a risk factor for heart failure (HF). Patients with CKD without diagnosed HF have an increased burden of symptoms characteristic of HF. It is not known whether these symptoms are associated with occurrence of new onset HF. </p><p><b><i>Methods and Results</i></b>—We studied the association of a modified Kansas City Cardiomyopathy Questionnaire (KCCQ) with newly identified cases of hospitalized HF among 3,093 participants enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study who did not report HF at baseline. The yearly-updated KCCQ score was categorized into quartiles (Q1-4) with the lower scores representing the worse symptoms. Multivariable-adjusted repeated measure logistic regression models were adjusted for demographic characteristics, clinical risk factors for HF, N-terminal pro-brain natriuretic peptide (NT-proBNP) level and left ventricular hypertrophy, left ventricular systolic and diastolic dysfunction. Over a mean (± standard deviation) follow up period of 4.3±1.6 years, there were 211 new cases of HF hospitalizations. The risk of HF hospitalization increased with increasing symptom quartiles; 2.62, 1.85, 1.14 and 0.74 events per 100 person-years, respectively. The median number of annual KCCQ assessments per participant was 5 (interquartile range 3 - 6). The annually updated KCCQ score was independently associated with higher risk of incident HF hospitalization in multivariable adjusted models (OR 3.30 (1.66 - 6.52); p=0.001 for Q1 compared with Q4). </p><p><b><i>Conclusions</i></b>—Symptoms characteristic of HF are common in CKD patients and are associated with higher short-term risk for new hospitalization for HF, independent of level of kidney function and other known HF risk factors.</p> 4 0 0 0 0 no yes CircHF_CIRCHF-2015-002097-A.xml CircHF_CIRCHF-2015-002097-A_file1.doc CircHF_CIRCHF-2015-002097-A_supp1.pdf 002097 Clinical Perspective.docx CircHF_CIRCHF-2015-002097-A_merge.pdf CircHF_CIRCHF-2015-002097-A_Chen_20601_disclosure.pdf CircHF_CIRCHF-2015-002097-A_Chen_20601_copyright.pdf CircHF_CIRCHF-2015-002097-A_Bansal_165101_disclosure.pdf CircHF_CIRCHF-2015-002097-A_Bansal_165101_copyright.pdf CircHF_CIRCHF-2015-002097-A_Feldman_168430_disclosure.pdf CircHF_CIRCHF-2015-002097-A_Feldman_168430_copyright.pdf CircHF_CIRCHF-2015-002097-A_DeFilippi_16919_disclosure.pdf CircHF_CIRCHF-2015-002097-A_DeFilippi_16919_copyright.pdf CircHF_CIRCHF-2015-002097-A_Delafontaine_3071_disclosure.pdf CircHF_CIRCHF-2015-002097-A_Delafontaine_3071_copyright.pdf CircHF_CIRCHF-2015-002097-A_Shlipak_40502_disclosure.pdf CircHF_CIRCHF-2015-002097-A_Shlipak_40502_copyright.pdf CircHF_CIRCHF-2015-002097-A_Rosas_21288_disclosure.pdf CircHF_CIRCHF-2015-002097-A_Rosas_21288_copyright.pdf CircHF_CIRCHF-2015-002097-A_Roy_212700_disclosure.pdf CircHF_CIRCHF-2015-002097-A_Roy_212700_copyright.pdf CircHF_CIRCHF-2015-002097-A_Go_53711_disclosure.pdf CircHF_CIRCHF-2015-002097-A_Go_53711_copyright.pdf CircHF_CIRCHF-2015-002097-A_Mishra_199615_disclosure.pdf CircHF_CIRCHF-2015-002097-A_Mishra_199615_copyright.pdf CircHF_CIRCHF-2015-002097-A_Yang_162170_disclosure.pdf CircHF_CIRCHF-2015-002097-A_Yang_162170_copyright.pdf CircHF_CIRCHF-2015-002097-A_Kusek_85135_disclosure.pdf CircHF_CIRCHF-2015-002097-A_Kusek_85135_copyright.pdf CircHF_CIRCHF-2015-002097-A_Kallem_41462_disclosure.pdf CircHF_CIRCHF-2015-002097-A_Kallem_41462_copyright.pdf CircHF_CIRCHF-2015-002097-A_Anderson_109126_disclosure.pdf CircHF_CIRCHF-2015-002097-A_Anderson_109126_copyright.pdf CircHF_CIRCHF-2015-002097-A_Lora_215874_disclosure.pdf CircHF_CIRCHF-2015-002097-A_Lora_215874_copyright.pdf Please charge authors $70 per page MS has clinical perspective and supplemental PDF Subject Codes: [110] Congestive epicillo