Table S1: Description of H. parasuis isolates included in pan-genome analysis with basic clinical meta-data.,,,,,,, "Where isolates with the same strain name have been provided they have been labelled also by country of the lab that prodivded them. Den - Denmark, Aus- Australia",,,,,,, Isolate ID,LOLA number,Disease Associated,Phenotype,Serovar,Country,BAPS Population,Accession 131,HS376,Non-clinical,Non-clinical,6,Switzerland,2,ERS132177 2725,HS315,Clinical,Systemic,Unknown,Germany,5,ERS132067 29755,AB,Clinical,Respiratory,5,USA,5,ABKM00000000 06-3517,HS335,Clinical,Systemic,Unknown,Belgium,1,ERS132087 7204096,HS352,Clinical,Systemic,9,Denmark,1,ERS132129 7204136,HS353,Clinical,Respiratory,5,Denmark,5,ERS193696 7204194,HS355,Clinical,Respiratory,13,Denmark,1,ERS132132 7204226,HS357,Clinical,Respiratory,14,Denmark,5,ERS132134 7204227,HS356,Clinical,Systemic,13,Denmark,1,ERS132133 7204283,HS359,Clinical,Respiratory,NT,Denmark,1,ERS132136 7303127,HS362,Clinical,Respiratory,NT,Denmark,1,ERS132139 7303168,HS361,Clinical,Respiratory,5,Denmark,5,ERS132138 7303223,HS363,Clinical,Respiratory,4,Denmark,5,ERS132140 7303695,HS364,Clinical,Respiratory,4,Denmark,5,ERS132141 7304152,HS366,Clinical,Systemic,6,Denmark,1,ERS132143 7403200,HS368,Clinical,Systemic,NT,Denmark,1,ERS132145 7403201,HS369,Clinical,Systemic,5,Denmark,5,ERS132146 9806235,HS342,Clinical,Respiratory,4,Denmark,1,ERS132119 9806397,HS343,Clinical,Systemic,5,Denmark,5,ERS132120 9904471,HS360,Clinical,Respiratory,7,Denmark,5,ERS132137 9904503,HS345,Clinical,Respiratory,5,Denmark,5,ERS132122 9904791,HS346,Clinical,Systemic,2,Denmark,1,ERS132123 9905038,HS348,Clinical,Respiratory,NT,Denmark,5,ERS132125 9905110,HS350,Clinical,Systemic,NT,Denmark,1,ERS132127 9914774,HS349,Clinical,Respiratory,13,Denmark,5,ERS132126 9915176,HS351,Clinical,Respiratory,4,Denmark,5,ERS193695 167/03,HS334,Clinical,Respiratory,NT,Spain,1,ERS132086 174-Den,HS377,Unknown,Unknown,7,Sweden,1,ERS132178 174-Spain,HS305,Unknown,Unknown,7,Sweden,1,ERS132057 228/04,HS311,Clinical,Respiratory,5,Spain,5,ERS132063 264/99,HS310,Clinical,Systemic,5,Spain,5,ERS132062 279/03,HS333,Clinical,Respiratory,NT,Spain,2,ERS132085 29755-Intervet,HS0012,Unknown,Unknown,5,USA,5,ERS132188 373/03A,HS308,Clinical,Systemic,NT,Spain,5,ERS132060 7204167-1-Spain,HS354,Clinical,Systemic,15,Denmark,2,ERS193697 7204167-1-Den,HS336,Clinical,Systemic,Unknown,Denmark,2,ERS132088 7211027-2,HS358,Clinical,Respiratory,1,Denmark,1,ERS132135 7312429-1,HS365,Clinical,Systemic,13,Denmark,5,ERS132142 7410325-2,HS367,Clinical,Respiratory,13,Denmark,5,ERS132144 9904108-Den,HS316,Clinical,Systemic,Unknown,Denmark,1,ERS132068 9904108-Spain,HS344,Clinical,Systemic,4,Denmark,1,ERS132121 C5-Den,HS378,Unknown,Unknown,8,Sweden,2,ERS132179 C5-Spain,HS302,Unknown,Unknown,8,Sweden,2,ERS132054 CA38/4,HS325,Unknown,Unknown,Unknown,Spain,5,ERS132077 CC2-2,HS332,Non-clinical,Non-clinical,Unknown,Spain,2,ERS132084 CD9-1,HS328,Non-clinical,Non-clinical,NT,Spain,2,ERS132080 CN8-1,HS331,Non-clinical,Non-clinical,Unknown,Spain,2,ERS132083 CN9-2,HS330,Non-clinical,Non-clinical,Unknown,Spain,2,ERS132082 D74-Aus,HS389,Unknown,Unknown,9,Germany,2,ERS214846 D74-Den,HS379,Unknown,Unknown,9,Germany,2,ERS132180 ER-6P,HS307,Clinical,Systemic,Unknown,Spain,5,ERS132059 F9,HS327,Non-clinical,Non-clinical,Unknown,Spain,2,ERS132079 FL1-3,HS326,Non-clinical,Non-clinical,Unknown,Spain,2,ERS132078 H425,HS381,Clinical,Respiratory,12,Germany,5,ERS132182 H465-Den,HS380,Unknown,Unknown,11,Germany,1,ERS132181 H465-Spain,HS304,Unknown,Unknown,11,Germany,1,ERS132056 H555,HS370,Unknown,Unknown,10,Japan,2,ERS132147 HS0001,HS0001,Clinical,Systemic,Unknown,Unknown,3,ERS132189 HS0003,HS0003,Clinical,Respiratory,Unknown,Unknown,1,ERS132199 HS0004,HS0004,Clinical,Systemic,NT,UK,4,ERS132193 HS0005,HS0005,Clinical,Respiratory,4,UK,1,ERS132195 HS0006,HS0006,Clinical,Respiratory,13,UK,3,ERS132191 HS0007,HS0007,Clinical,Systemic,2,UK,1,ERS132194 HS0008,HS0008,Non-clinical,Non-clinical,Unknown,UK,3,ERS132197 HS0009,HS0009,Clinical,Respiratory,Unknown,UK,3,ERS132192 HS001,HS001,Clinical,Systemic,Unknown,UK,1,ERS131963 HS0010,HS0010,Clinical,Systemic,Unknown,Unknown,1,ERS132196 HS002,HS002,Clinical,Systemic,Unknown,UK,3,ERS131964 HS003,HS003,Clinical,Respiratory,Unknown,UK,1,ERS131965 HS004,HS004,Clinical,Respiratory,Unknown,UK,4,ERS131966 HS005,HS005,Clinical,Respiratory,Unknown,UK,1,ERS131967 HS006,HS006,Clinical,Respiratory,Unknown,UK,1,ERS131968 HS008,HS008,Clinical,Respiratory,Unknown,UK,1,ERS131969 HS009,HS009,Unknown,Unknown,Unknown,UK,1,ERS131970 HS010,HS010,Clinical,Respiratory,Unknown,UK,1,ERS131971 HS011,HS011,Clinical,Respiratory,Unknown,UK,1,ERS131972 HS012,HS012,Unknown,Unknown,Unknown,UK,1,ERS131973 HS013,HS013,Clinical,Respiratory,Unknown,UK,1,ERS131974 HS014,HS014,Clinical,Systemic,Unknown,UK,1,ERS131975 HS015,HS015,Clinical,Respiratory,Unknown,UK,4,ERS131976 HS016,HS016,Clinical,Systemic,Unknown,UK,1,ERS131977 HS017,HS017,Clinical,Systemic,Unknown,UK,1,ERS131978 HS018,HS018,Clinical,Respiratory,Unknown,UK,1,ERS131979 HS019,HS019,Clinical,Respiratory,Unknown,UK,4,ERS131980 HS020,HS020,Clinical,Systemic,Unknown,UK,3,ERS131981 HS021,HS021,Clinical,Respiratory,Unknown,UK,4,ERS131982 HS022,HS022,Clinical,Respiratory,Unknown,UK,1,ERS131983 HS023,HS023,Clinical,Respiratory,Unknown,UK,1,ERS132095 HS024,HS024,Clinical,Respiratory,Unknown,UK,1,ERS131984 HS025,HS025,Clinical,Respiratory,Unknown,UK,1,ERS131985 HS026,HS026,Clinical,Respiratory,Unknown,UK,1,ERS131986 HS027,HS027,Clinical,Respiratory,Unknown,UK,1,ERS131987 HS028,HS028,Clinical,Systemic,Unknown,UK,1,ERS131988 HS029,HS029,Clinical,Systemic,Unknown,UK,1,ERS131989 HS030,HS030,Clinical,Systemic,Unknown,UK,1,ERS131990 HS032,HS032,Clinical,Respiratory,NT,UK,4,ERS132116 HS033,HS033,Clinical,Respiratory,6,UK,2,ERS131992 HS034,HS034,Clinical,Respiratory,14,UK,5,ERS131993 HS035,HS035,Clinical,Respiratory,7,UK,4,ERS131994 HS036,HS036,Clinical,Respiratory,NT,UK,1,ERS131995 HS037,HS037,Clinical,Systemic,13,UK,1,ERS131996 HS038,HS038,Clinical,Respiratory,2,UK,1,ERS131997 HS039,HS039,Clinical,Respiratory,7,UK,1,ERS131998 HS040,HS040,Clinical,Systemic,7,UK,4,ERS131999 HS041,HS041,Clinical,Respiratory,7,UK,1,ERS132000 HS042,HS042,Clinical,Respiratory,4,UK,1,ERS132001 HS043,HS043,Clinical,Respiratory,Unknown,UK,3,ERS132002 HS044,HS044,Clinical,Respiratory,5,UK,3,ERS132003 HS045,HS045,Unknown,Unknown,14,UK,5,ERS132004 HS046,HS046,Clinical,Respiratory,7,UK,1,ERS132005 HS047,HS047,Clinical,Respiratory,NT,UK,3,ERS132006 HS050,HS050,Clinical,Respiratory,Unknown,UK,1,ERS132009 HS051,HS051,Clinical,Systemic,Unknown,UK,2,ERS132010 HS052,HS052,Clinical,Respiratory,13,UK,1,ERS132011 HS053,HS053,Clinical,Systemic,5,UK,3,ERS132012 HS054,HS054,Clinical,Systemic,4,UK,4,ERS132013 HS055,HS055,Clinical,Systemic,9,UK,2,ERS132014 HS056,HS056,Clinical,Respiratory,5,UK,3,ERS132015 HS057,HS057,Unknown,Unknown,Unknown,Greece,2,ERS132016 HS058,HS058,Unknown,Unknown,7,UK,4,ERS132017 HS059,HS059,Unknown,Unknown,NT,UK,4,ERS132018 HS060,HS060,Unknown,Unknown,NT,UK,1,ERS132019 HS061,HS061,Clinical,Respiratory,5,UK,3,ERS132020 HS062,HS062,Unknown,Unknown,4,UK,3,ERS132021 HS063,HS063,Clinical,Respiratory,7,UK,3,ERS132022 HS064,HS064,Clinical,Respiratory,12,UK,3,ERS132090 HS065,HS065,Clinical,Respiratory,13,UK,1,ERS132023 HS068,HS068,Unknown,Unknown,6,UK,4,ERS132024 HS069,HS069,Clinical,Respiratory,5,UK,3,ERS132117 HS070,HS070,Clinical,Respiratory,12,UK,3,ERS132025 HS073,HS073,Clinical,Respiratory,7,UK,2,ERS132026 HS074,HS074,Clinical,Respiratory,4,UK,1,ERS132027 HS075,HS075,Clinical,Systemic,4,UK,1,ERS132028 HS076,HS076,Clinical,Respiratory,2,UK,1,ERS132029 HS077,HS077,Clinical,Respiratory,12,UK,1,ERS132030 HS078,HS078,Non-clinical,Non-clinical,NT,UK,1,ERS132031 HS079,HS079,Non-clinical,Non-clinical,Unknown,UK,1,ERS132032 HS080,HS080,Non-clinical,Non-clinical,Unknown,UK,1,ERS132033 HS081,HS081,Non-clinical,Non-clinical,Unknown,UK,1,ERS132034 HS082,HS082,Non-clinical,Non-clinical,Unknown,UK,1,ERS132035 HS083,HS083,Non-clinical,Non-clinical,Unknown,UK,1,ERS132036 HS084,HS084,Non-clinical,Non-clinical,Unknown,UK,1,ERS132037 HS085,HS085,Non-clinical,Non-clinical,Unknown,UK,1,ERS132038 HS086,HS086,Non-clinical,Non-clinical,Unknown,UK,1,ERS132039 HS087,HS087,Non-clinical,Non-clinical,NT,UK,2,ERS132040 HS088,HS088,Non-clinical,Non-clinical,5,UK,3,ERS132041 HS089,HS089,Non-clinical,Non-clinical,Unknown,UK,1,ERS132042 HS090,HS090,Non-clinical,Non-clinical,Unknown,UK,1,ERS132043 HS091,HS091,Non-clinical,Non-clinical,5,UK,3,ERS132044 HS092,HS092,Non-clinical,Non-clinical,5,UK,3,ERS132045 HS094,HS094,Clinical,Respiratory,12,UK,3,ERS132046 HS095,HS095,Clinical,Respiratory,Unknown,UK,1,ERS132047 HS097,HS097,Clinical,Systemic,4,UK,4,ERS132048 HS098,HS098,Clinical,Systemic,Unknown,UK,1,ERS132049 HS099,HS099,Clinical,Systemic,NT,UK,4,ERS132050 HS100,HS100,Clinical,Respiratory,2,UK,1,ERS132051 HS101,HS101,Clinical,Respiratory,NT,UK,4,ERS132052 HS145,HS385,Unknown,Unknown,1,Unknown,1,ERS214842 HS197,HS388,Unknown,Unknown,7,Unknown,1,ERS214845 HS201,HS201,Unknown,Unknown,Unknown,UK,2,ERS132096 HS203,HS203,Unknown,Unknown,Unknown,UK,2,ERS132097 HS205,HS205,Unknown,Unknown,Unknown,UK,1,ERS132098 HS208,HS208,Unknown,Unknown,Unknown,UK,2,ERS132150 HS209,HS209,Unknown,Unknown,Unknown,UK,2,ERS132151 HS211,HS211,Unknown,Unknown,Unknown,UK,1,ERS132099 HS212,HS212,Unknown,Unknown,Unknown,UK,3,ERS132100 HS217,HS217,Non-clinical,Non-clinical,Unknown,UK,4,ERS132101 HS218,HS218,Non-clinical,Non-clinical,Unknown,UK,1,ERS132102 HS219,HS219,Non-clinical,Non-clinical,Unknown,UK,4,ERS132103 HS220,HS220,Unknown,Unknown,Unknown,UK,5,ERS132104 HS221,HS221,Unknown,Unknown,Unknown,UK,5,ERS132105 HS223,HS223,Unknown,Unknown,Unknown,UK,2,ERS132106 HS227,HS227,Unknown,Unknown,Unknown,UK,1,ERS132161 HS228,HS228,Unknown,Unknown,Unknown,UK,1,ERS132107 HS232,HS232,Non-clinical,Non-clinical,Unknown,UK,1,ERS132108 HS233,HS233,Unknown,Unknown,Unknown,UK,2,ERS132109 HS235,HS235,Non-clinical,Non-clinical,Unknown,UK,1,ERS132110 HS236,HS236,Non-clinical,Non-clinical,Unknown,UK,2,ERS132111 HS237,HS237,Non-clinical,Non-clinical,Unknown,UK,2,ERS132112 HS238,HS238,Unknown,Unknown,Unknown,UK,1,ERS132113 HS239,HS239,Non-clinical,Non-clinical,Unknown,UK,1,ERS132114 HS240,HS240,Non-clinical,Non-clinical,Unknown,UK,2,ERS132115 HS250,HS250,Clinical,Systemic,11,UK,3,ERS132168 HS254,HS254,Clinical,Systemic,14,UK,3,ERS132171 HS323,HS323,Unknown,Unknown,Unknown,Spain,2,ERS132075 HS367,HS390,Non-clinical,Non-clinical,10,Unknown,5,ERS214847 HS405,HS405,Unknown,Unknown,Unknown,Unknown,5,ERS134375 IA-84-17975-Aus,HS391,Unknown,Unknown,14,USA,5,ERS214848 IA-84-17975-Den,HS382,Unknown,Unknown,13,USA,5,ERS132183 IA-84-22113,HS306,Clinical,Systemic,14,USA,5,ERS132058 IT14187-7,HS337,Clinical,Respiratory,Unknown,Italy,1,ERS132089 IT29205,HS314,Clinical,Systemic,Unknown,Italy,5,ERS132066 MU21-2,HS324,Non-clinical,Non-clinical,Unknown,Spain,2,ERS132076 Nagasaki-Aus,HS387,Clinical,Systemic,5,Japan,5,ERS214844 Nagasaki-Den,HS375,Unknown,Unknown,5,Switzerland,5,ERS132176 No.4,HS371,Non-clinical,Non-clinical,1,Unknown,1,ERS193698 P015/96,HS312,Clinical,Respiratory,5,Argentina,5,ERS132064 PC4-6P,HS313,Clinical,Systemic,Unknown,Spain,5,ERS132065 PV1-12,HS309,Clinical,Systemic,Unknown,Spain,1,ERS132061 RU15-4P,HS317,Clinical,Systemic,Unknown,Spain,5,ERS132069 RU9-1,HS329,Non-clinical,Non-clinical,Unknown,Spain,2,ERS132081 SD-84-15995,HS301,Clinical,Respiratory,15,USA,5,ERS132053 serovar3-Intervet,HS0011,Unknown,Unknown,3,Unknown,2,ERS132198 SH0165,CP,Clinical,Respiratory,5,China,5,CP001321 SL3-2,HS320,Non-clinical,Non-clinical,Unknown,Spain,1,ERS132072 SW114-Den,HS373,Non-clinical,Non-clinical,3,Japan,2,ERS132174 SW114-Spain,HS303,Non-clinical,Non-clinical,3,Japan,2,ERS132055 SW124,HS374,Non-clinical,Non-clinical,4,Japan,1,ERS132175 SW140-Aus,HS386,Non-clinical,Non-clinical,2,Japan,1,ERS214843 SW140-Den,HS372,Non-clinical,Non-clinical,2,Japan,1,ERS132173 VS6-2,HS321,Non-clinical,Non-clinical,Unknown,Spain,2,ERS132073 ZJ0906,ZJ0906,Clinical,Respiratory,12,China,5,CP005384