##The most enriched pathway or disease terms: ##Statistic method: hypergeometric test ##FDR correction method: Benjamini and Hochberg (1995) #Term Database Id Sample number Background number P-Value Corrected P-Value Genes KO Entrez_ID Ensembl_ID KO_name Hyperlink Metabolic pathways (domestic silkworm) KEGG PATHWAY bmor01100 31 665 0.000784962609313 0.0996902513828 BGIBMGA014049|BGIBMGA007111|BGIBMGA006968|BGIBMGA001160|BGIBMGA011774|BGIBMGA001129|BGIBMGA004251|BGIBMGA005528|BGIBMGA010403|BGIBMGA007343|BGIBMGA000572|BGIBMGA001648|BGIBMGA008283|Novel00560|BGIBMGA004276|BGIBMGA004277|BGIBMGA007121|Novel01254|BGIBMGA000121|BGIBMGA000236|BGIBMGA010764|BGIBMGA012123|BGIBMGA002349|BGIBMGA004208|BGIBMGA001291|Novel00592|BGIBMGA009467|BGIBMGA005537|BGIBMGA011964|BGIBMGA006419|BGIBMGA008401|BGIBMGA006246 bmor:733033|bmor:101737414|bmor:692509|bmor:101735515|bmor:101736818|bmor:101741392|bmor:732996|bmor:101737137|bmor:692889|bmor:101743531|bmor:100141424|bmor:101743914|bmor:100329154|bmor:101738038|bmor:733130|bmor:733130|bmor:101738186|bmor:101735646|bmor:101737047|bmor:100190958|bmor:101744108|bmor:101745635|bmor:733011|bmor:692944|bmor:101744799|bmor:101746707|bmor:101746460|bmor:101736504|bmor:101743445|bmor:100101182|bmor:101743834|bmor:101740919| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | 733033|101737414|692509|101735515|101736818|101741392|732996|101737137|692889|101743531|100141424|101743914|100329154|101738038|733130|733130|101738186|101735646|101737047|100190958|101744108|101745635|733011|692944|101744799|101746707|101746460|101736504|101743445|100101182|101743834|101740919| None|None|None|None|None|None|None|None|None|None|None|None|None|None|None|None|None|None|None|None|None|None|None|None|None|None|None|None|None|None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor01100 Glutathione metabolism (domestic silkworm) KEGG PATHWAY bmor00480 5 41 0.00388720497623 0.19666455775 BGIBMGA002222|BGIBMGA004251|BGIBMGA004447|BGIBMGA010764|BGIBMGA011658 bmor:692521|bmor:732996|bmor:101745413|bmor:101744108|bmor:692941| | | | | | 692521|732996|101745413|101744108|692941| None|None|None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00480 Pyruvate metabolism (domestic silkworm) KEGG PATHWAY bmor00620 4 27 0.00480264836839 0.19666455775 BGIBMGA006419|BGIBMGA010403|BGIBMGA006246|BGIBMGA004276|BGIBMGA004277 bmor:100101182|bmor:692889|bmor:101740919|bmor:733130|bmor:733130| | | | | | 100101182|692889|101740919|733130|733130| None|None|None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00620 Nicotinate and nicotinamide metabolism (domestic silkworm) KEGG PATHWAY bmor00760 3 15 0.00619415929921 0.19666455775 BGIBMGA014049|BGIBMGA001160|BGIBMGA011774 bmor:733033|bmor:101735515|bmor:101736818| | | | 733033|101735515|101736818| None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00760 Valine, leucine and isoleucine degradation (domestic silkworm) KEGG PATHWAY bmor00280 3 30 0.0416699764107 0.922112783563 BGIBMGA000236|BGIBMGA005528|BGIBMGA010403 bmor:100190958|bmor:101737137|bmor:692889| | | | 100190958|101737137|692889| None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00280 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis (domestic silkw KEGG PATHWAY bmor00563 3 33 0.0529585888849 0.922112783563 Novel00560|Novel00592|BGIBMGA000121 bmor:101738038|bmor:101746707|bmor:101737047| | | | 101738038|101746707|101737047| None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00563 Fanconi anemia pathway (domestic silkworm) KEGG PATHWAY bmor03460 4 55 0.0535422343781 0.922112783563 BGIBMGA008315|BGIBMGA013837|BGIBMGA012027|BGIBMGA005251 bmor:101738854|bmor:101740773|bmor:101741322|bmor:101747068| | | | | 101738854|101740773|101741322|101747068| None|None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor03460 Inositol phosphate metabolism (domestic silkworm) KEGG PATHWAY bmor00562 3 36 0.0655583970932 0.922112783563 BGIBMGA008283|BGIBMGA005537|Novel01254 bmor:100329154|bmor:101736504|bmor:101735646| | | | 100329154|101736504|101735646| None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00562 Lysosome (domestic silkworm) KEGG PATHWAY bmor04142 4 62 0.0763962937856 0.922112783563 BGIBMGA000222|BGIBMGA009191|BGIBMGA001129|BGIBMGA001291 bmor:101747227|bmor:101744899|bmor:101741392|bmor:101744799| | | | | 101747227|101744899|101741392|101744799| None|None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor04142 Tryptophan metabolism (domestic silkworm) KEGG PATHWAY bmor00380 2 19 0.0857223726894 0.922112783563 BGIBMGA006968|BGIBMGA010403 bmor:692509|bmor:692889| | | 692509|692889| None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00380 Carbon metabolism (domestic silkworm) KEGG PATHWAY bmor01200 4 65 0.0874754490532 0.922112783563 BGIBMGA006419|BGIBMGA012123|BGIBMGA006246|BGIBMGA007121 bmor:100101182|bmor:101745635|bmor:101740919|bmor:101738186| | | | | 100101182|101745635|101740919|101738186| None|None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor01200 beta-Alanine metabolism (domestic silkworm) KEGG PATHWAY bmor00410 2 20 0.0936786313037 0.922112783563 BGIBMGA007111|BGIBMGA010403 bmor:101737414|bmor:692889| | | 101737414|692889| None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00410 Phosphatidylinositol signaling system (domestic silkworm) KEGG PATHWAY bmor04070 3 42 0.09438949753 0.922112783563 BGIBMGA008283|BGIBMGA005537|Novel01254 bmor:100329154|bmor:101736504|bmor:101735646| | | | 100329154|101736504|101735646| None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor04070 Cysteine and methionine metabolism (domestic silkworm) KEGG PATHWAY bmor00270 2 21 0.101838416675 0.923819922692 BGIBMGA004208|BGIBMGA012123 bmor:692944|bmor:101745635| | | 692944|101745635| None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00270 Glyoxylate and dicarboxylate metabolism (domestic silkworm) KEGG PATHWAY bmor00630 2 22 0.110185978716 0.932907953127 BGIBMGA002349|BGIBMGA007121 bmor:733011|bmor:101738186| | | 733011|101738186| None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00630 Drug metabolism - cytochrome P450 (domestic silkworm) KEGG PATHWAY bmor00982 2 24 0.127384764056 0.979391281685 BGIBMGA002222|BGIBMGA011658 bmor:692521|bmor:692941| | | 692521|692941| None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00982 Metabolism of xenobiotics by cytochrome P450 (domestic silkworm) KEGG PATHWAY bmor00980 2 25 0.136207747963 0.979391281685 BGIBMGA002222|BGIBMGA011658 bmor:692521|bmor:692941| | | 692521|692941| None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00980 Jak-STAT signaling pathway (domestic silkworm) KEGG PATHWAY bmor04630 2 27 0.154234847509 0.979391281685 Novel01293|Novel00598 bmor:100302627|bmor:100862763| | | 100302627|100862763| None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor04630 Citrate cycle (TCA cycle) (domestic silkworm) KEGG PATHWAY bmor00020 2 27 0.154234847509 0.979391281685 BGIBMGA004276|BGIBMGA004277|BGIBMGA007121 bmor:733130|bmor:733130|bmor:101738186| | | | 733130|733130|101738186| None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00020 Sphingolipid metabolism (domestic silkworm) KEGG PATHWAY bmor00600 2 27 0.154234847509 0.979391281685 BGIBMGA011964|BGIBMGA001129 bmor:101743445|bmor:101741392| | | 101743445|101741392| None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00600 Peroxisome (domestic silkworm) KEGG PATHWAY bmor04146 4 84 0.173184905366 1.0 BGIBMGA014087|Novel00048|BGIBMGA007722|BGIBMGA011395 bmor:732921|bmor:101739612|bmor:101737781|bmor:101741449| | | | | 732921|101739612|101737781|101741449| None|None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor04146 Arginine and proline metabolism (domestic silkworm) KEGG PATHWAY bmor00330 2 30 0.182047210272 1.0 BGIBMGA004251|BGIBMGA010403 bmor:732996|bmor:692889| | | 732996|692889| None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00330 Glycerolipid metabolism (domestic silkworm) KEGG PATHWAY bmor00561 2 30 0.182047210272 1.0 BGIBMGA000572|BGIBMGA010403 bmor:100141424|bmor:692889| | | 100141424|692889| None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00561 RNA degradation (domestic silkworm) KEGG PATHWAY bmor03018 3 60 0.203256097075 1.0 BGIBMGA002671|BGIBMGA009854|BGIBMGA008899 bmor:733040|bmor:101737241|bmor:692825| | | | 733040|101737241|692825| None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor03018 Steroid biosynthesis (domestic silkworm) KEGG PATHWAY bmor00100 1 9 0.210729091865 1.0 Novel00691 bmor:101740142| | 101740142| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00100 Glycolysis / Gluconeogenesis (domestic silkworm) KEGG PATHWAY bmor00010 2 34 0.220118378393 1.0 BGIBMGA010403|BGIBMGA004276|BGIBMGA004277 bmor:692889|bmor:733130|bmor:733130| | | | 692889|733130|733130| None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00010 Selenocompound metabolism (domestic silkworm) KEGG PATHWAY bmor00450 1 10 0.231228001685 1.0 BGIBMGA010797 bmor:101735767| | 101735767| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00450 Ribosome biogenesis in eukaryotes (domestic silkworm) KEGG PATHWAY bmor03008 3 68 0.258403399205 1.0 BGIBMGA005597|BGIBMGA009207|BGIBMGA004933 bmor:101737448|bmor:101744824|bmor:100101167| | | | 101737448|101744824|100101167| None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor03008 Histidine metabolism (domestic silkworm) KEGG PATHWAY bmor00340 1 14 0.308065573257 1.0 BGIBMGA010403 bmor:692889| | 692889| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00340 Spliceosome (domestic silkworm) KEGG PATHWAY bmor03040 4 110 0.319034478735 1.0 BGIBMGA004963|BGIBMGA010488|BGIBMGA008899|BGIBMGA014536 bmor:101743352|bmor:101741443|bmor:692825|bmor:100862772| | | | | 101743352|101741443|692825|100862772| None|None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor03040 2-Oxocarboxylic acid metabolism (domestic silkworm) KEGG PATHWAY bmor01210 1 17 0.360639096278 1.0 BGIBMGA007121 bmor:101738186| | 101738186| None| http://www.genome.jp/kegg-bin/show_pathway?bmor01210 Regulation of autophagy (domestic silkworm) KEGG PATHWAY bmor04140 1 18 0.377265743902 1.0 BGIBMGA003954 bmor:100216353| | 100216353| None| http://www.genome.jp/kegg-bin/show_pathway?bmor04140 RNA transport (domestic silkworm) KEGG PATHWAY bmor03013 4 121 0.384314927036 1.0 BGIBMGA013026|BGIBMGA004127|Novel00284|BGIBMGA004933 bmor:101744517|bmor:101741753|bmor:101736370|bmor:100101167| | | | | 101744517|101741753|101736370|100101167| None|None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor03013 Pantothenate and CoA biosynthesis (domestic silkworm) KEGG PATHWAY bmor00770 1 19 0.393462597858 1.0 BGIBMGA007111 bmor:101737414| | 101737414| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00770 Ascorbate and aldarate metabolism (domestic silkworm) KEGG PATHWAY bmor00053 1 19 0.393462597858 1.0 BGIBMGA010403 bmor:692889| | 692889| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00053 Sulfur metabolism (domestic silkworm) KEGG PATHWAY bmor00920 1 19 0.393462597858 1.0 BGIBMGA012123 bmor:101745635| | 101745635| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00920 Circadian rhythm - fly (domestic silkworm) KEGG PATHWAY bmor04711 1 20 0.409240701361 1.0 BGIBMGA006227 bmor:733065| | 733065| None| http://www.genome.jp/kegg-bin/show_pathway?bmor04711 Aminoacyl-tRNA biosynthesis (domestic silkworm) KEGG PATHWAY bmor00970 2 54 0.410709604644 1.0 BGIBMGA000851|BGIBMGA010797 bmor:101746251|bmor:101735767| | | 101746251|101735767| None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00970 Phagosome (domestic silkworm) KEGG PATHWAY bmor04145 2 54 0.410709604644 1.0 BGIBMGA001546|BGIBMGA000217 bmor:101742268|bmor:101736734| | | 101742268|101736734| None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor04145 Dorso-ventral axis formation (domestic silkworm) KEGG PATHWAY bmor04320 1 21 0.424610815596 1.0 Novel00598 bmor:100862763| | 100862763| None| http://www.genome.jp/kegg-bin/show_pathway?bmor04320 Homologous recombination (domestic silkworm) KEGG PATHWAY bmor03440 1 22 0.439583426876 1.0 BGIBMGA002778 bmor:101744594| | 101744594| None| http://www.genome.jp/kegg-bin/show_pathway?bmor03440 Mismatch repair (domestic silkworm) KEGG PATHWAY bmor03430 1 22 0.439583426876 1.0 BGIBMGA012027 bmor:101741322| | 101741322| None| http://www.genome.jp/kegg-bin/show_pathway?bmor03430 Pyrimidine metabolism (domestic silkworm) KEGG PATHWAY bmor00240 3 98 0.469667265824 1.0 BGIBMGA014049|BGIBMGA007111|BGIBMGA011774 bmor:733033|bmor:101737414|bmor:101736818| | | | 733033|101737414|101736818| None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00240 SNARE interactions in vesicular transport (domestic silkworm) KEGG PATHWAY bmor04130 1 25 0.482217128386 1.0 BGIBMGA007350 bmor:101735547| | 101735547| None| http://www.genome.jp/kegg-bin/show_pathway?bmor04130 mRNA surveillance pathway (domestic silkworm) KEGG PATHWAY bmor03015 2 63 0.489593477879 1.0 BGIBMGA009595|BGIBMGA004933 bmor:101744320|bmor:100101167| | | 101744320|100101167| None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor03015 Biosynthesis of amino acids (domestic silkworm) KEGG PATHWAY bmor01230 2 65 0.506221157998 1.0 BGIBMGA012123|BGIBMGA007121 bmor:101745635|bmor:101738186| | | 101745635|101738186| None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor01230 Drug metabolism - other enzymes (domestic silkworm) KEGG PATHWAY bmor00983 1 27 0.508832583635 1.0 BGIBMGA007111 bmor:101737414| | 101737414| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00983 Purine metabolism (domestic silkworm) KEGG PATHWAY bmor00230 3 104 0.509331859563 1.0 BGIBMGA014049|BGIBMGA010092|BGIBMGA011774 bmor:733033|bmor:692412|bmor:101736818| | | | 733033|692412|101736818| None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00230 Nitrogen metabolism (domestic silkworm) KEGG PATHWAY bmor00910 1 31 0.558052162573 1.0 BGIBMGA002647 bmor:692876| | 692876| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00910 MAPK signaling pathway - fly (domestic silkworm) KEGG PATHWAY bmor04013 1 32 0.569570790252 1.0 Novel00598 bmor:100862763| | 100862763| None| http://www.genome.jp/kegg-bin/show_pathway?bmor04013 Fatty acid degradation (domestic silkworm) KEGG PATHWAY bmor00071 1 34 0.591720471674 1.0 BGIBMGA010403 bmor:692889| | 692889| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00071 Proteasome (domestic silkworm) KEGG PATHWAY bmor03050 1 37 0.622838410807 1.0 BGIBMGA000971 bmor:101737354| | 101737354| None| http://www.genome.jp/kegg-bin/show_pathway?bmor03050 Wnt signaling pathway (domestic silkworm) KEGG PATHWAY bmor04310 2 81 0.626099864135 1.0 BGIBMGA008283|BGIBMGA000217 bmor:100329154|bmor:101736734| | | 100329154|101736734| None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor04310 Pentose and glucuronate interconversions (domestic silkworm) KEGG PATHWAY bmor00040 1 39 0.642262293683 1.0 BGIBMGA010403 bmor:692889| | 692889| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00040 Other glycan degradation (domestic silkworm) KEGG PATHWAY bmor00511 2 87 0.664895825004 1.0 BGIBMGA006905|BGIBMGA001129 bmor:101743490|bmor:101741392| | | 101743490|101741392| None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor00511 Ribosome (domestic silkworm) KEGG PATHWAY bmor03010 3 131 0.666134499771 1.0 BGIBMGA004013|BGIBMGA000395|Novel00455 bmor:101737237|bmor:692709|bmor:693065| | | | 101737237|692709|693065| None|None|None| http://www.genome.jp/kegg-bin/show_pathway?bmor03010 Folate biosynthesis (domestic silkworm) KEGG PATHWAY bmor00790 1 42 0.669549329954 1.0 BGIBMGA008401 bmor:101743834| | 101743834| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00790 Lysine degradation (domestic silkworm) KEGG PATHWAY bmor00310 1 48 0.718070765948 1.0 BGIBMGA010403 bmor:692889| | 692889| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00310 Propanoate metabolism (domestic silkworm) KEGG PATHWAY bmor00640 1 49 0.725438805895 1.0 BGIBMGA010403 bmor:692889| | 692889| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00640 Porphyrin and chlorophyll metabolism (domestic silkworm) KEGG PATHWAY bmor00860 1 59 0.789366861438 1.0 BGIBMGA001648 bmor:101743914| | 101743914| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00860 Neuroactive ligand-receptor interaction (domestic silkworm) KEGG PATHWAY bmor04080 1 69 0.838479838019 1.0 BGIBMGA010460 bmor:101738582| | 101738582| None| http://www.genome.jp/kegg-bin/show_pathway?bmor04080 Glycosaminoglycan biosynthesis - heparan sulfate / heparin (domestic KEGG PATHWAY bmor00534 1 72 0.850857952857 1.0 BGIBMGA006776 bmor:101740692| | 101740692| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00534 Endocytosis (domestic silkworm) KEGG PATHWAY bmor04144 1 73 0.854770741153 1.0 BGIBMGA014536 bmor:100862772| | 100862772| None| http://www.genome.jp/kegg-bin/show_pathway?bmor04144 Notch signaling pathway (domestic silkworm) KEGG PATHWAY bmor04330 1 87 0.899951090653 1.0 Novel00980 bmor:692897| | 692897| None| http://www.genome.jp/kegg-bin/show_pathway?bmor04330 Oxidative phosphorylation (domestic silkworm) KEGG PATHWAY bmor00190 1 103 0.934717600186 1.0 BGIBMGA007343 bmor:101743531| | 101743531| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00190 Protein processing in endoplasmic reticulum (domestic silkworm) KEGG PATHWAY bmor04141 1 111 0.947288480128 1.0 BGIBMGA014536 bmor:100862772| | 100862772| None| http://www.genome.jp/kegg-bin/show_pathway?bmor04141 Glycosaminoglycan degradation (domestic silkworm) KEGG PATHWAY bmor00531 1 114 0.951354785446 1.0 BGIBMGA001291 bmor:101744799| | 101744799| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00531 ECM-receptor interaction (domestic silkworm) KEGG PATHWAY bmor04512 1 114 0.951354785446 1.0 BGIBMGA001935 bmor:101746167| | 101746167| None| http://www.genome.jp/kegg-bin/show_pathway?bmor04512 Amino sugar and nucleotide sugar metabolism (domestic silkworm) KEGG PATHWAY bmor00520 1 180 0.99176575345 1.0 BGIBMGA009467 bmor:101746460| | 101746460| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00520 Other types of O-glycan biosynthesis (domestic silkworm) KEGG PATHWAY bmor00514 1 309 0.999758375901 1.0 BGIBMGA007501 bmor:101746748| | 101746748| None| http://www.genome.jp/kegg-bin/show_pathway?bmor00514 -------------------- #Term Database Id Sample number Background number P-Value Corrected P-Value Genes KO Entrez_ID Ensembl_ID KO_name Hyperlink --------------------