BoneMarrow_GO_Terms GO.ID Term Annotated Significant Expected Rank in classicFisher classicFisher elimFisher GO:0008150 biological_process 2819 1031 1040.91 5569 0.99884 5.9E-010 GO:0050729 positive regulation of inflammatory resp... 14 12 5.17 1 0.00025 0.00018 GO:0007178 transmembrane receptor protein serine/th... 51 29 18.83 4 0.00273 0.0017 GO:0046888 negative regulation of hormone secretion 10 8 3.69 8 0.00695 0.00575 GO:0032729 positive regulation of interferon-gamma ... 5 5 1.85 5 0.00682 0.00597 GO:0032760 positive regulation of tumor necrosis fa... 5 5 1.85 6 0.00682 0.00597 GO:0050755 chemokine metabolic process 5 5 1.85 7 0.00682 0.00597 GO:0071621 granulocyte chemotaxis 16 11 5.91 12 0.00964 0.00766 GO:0015908 fatty acid transport 18 12 6.65 13 0.00984 0.00771 GO:0060389 pathway-restricted SMAD protein phosphor... 7 6 2.58 14 0.01204 0.01037 GO:0030509 BMP signaling pathway 23 14 8.49 15 0.01643 0.0127 GO:0010770 positive regulation of cell morphogenesi... 11 8 4.06 16 0.01727 0.01446 GO:0043487 regulation of RNA stability 11 8 4.06 17 0.01727 0.01446 GO:0071715 icosanoid transport 11 8 4.06 18 0.01727 0.01446 GO:1901571 fatty acid derivative transport 11 8 4.06 19 0.01727 0.01446 GO:0006694 steroid biosynthetic process 32 18 11.82 32 0.01967 0.01464 GO:0030593 neutrophil chemotaxis 13 9 4.8 23 0.0182 0.01504 GO:0010811 positive regulation of cell-substrate ad... 15 10 5.54 25 0.01847 0.01506 GO:0042033 chemokine biosynthetic process 4 4 1.48 26 0.01852 0.01664 GO:0045073 regulation of chemokine biosynthetic pro... 4 4 1.48 27 0.01852 0.01664 GO:0045815 positive regulation of gene expression, ... 4 4 1.48 28 0.01852 0.01664 GO:0051150 regulation of smooth muscle cell differe... 4 4 1.48 29 0.01852 0.01664 GO:1900024 regulation of substrate adhesion-depende... 4 4 1.48 30 0.01852 0.01664 GO:1900026 positive regulation of substrate adhesio... 4 4 1.48 31 0.01852 0.01664 GO:0016050 vesicle organization 22 13 8.12 34 0.02807 0.02227 GO:0090092 regulation of transmembrane receptor pro... 31 17 11.45 45 0.03115 0.02378 GO:0071216 cellular response to biotic stimulus 20 12 7.38 44 0.02986 0.024 GO:0003229 ventricular cardiac muscle tissue develo... 6 5 2.22 35 0.02838 0.02511 GO:0007257 activation of JUN kinase activity 6 5 2.22 36 0.02838 0.02511 GO:0010862 positive regulation of pathway-restricte... 6 5 2.22 37 0.02838 0.02511 GO:0033627 cell adhesion mediated by integrin 6 5 2.22 38 0.02838 0.02511 GO:0043489 RNA stabilization 6 5 2.22 39 0.02838 0.02511 GO:0048255 mRNA stabilization 6 5 2.22 40 0.02838 0.02511 GO:0048821 erythrocyte development 6 5 2.22 41 0.02838 0.02511 GO:0050482 arachidonic acid secretion 6 5 2.22 42 0.02838 0.02511 GO:0060393 regulation of pathway-restricted SMAD pr... 6 5 2.22 43 0.02838 0.02511 GO:0045785 positive regulation of cell adhesion 29 16 10.71 52 0.03384 0.02616 GO:0050795 regulation of behavior 29 16 10.71 53 0.03384 0.02616 GO:0006518 peptide metabolic process 16 10 5.91 51 0.03319 0.02739 GO:0048520 positive regulation of behavior 14 9 5.17 54 0.03447 0.02883 GO:1990266 neutrophil migration 14 9 5.17 55 0.03447 0.02883 GO:0002224 toll-like receptor signaling pathway 8 6 2.95 46 0.03311 0.02887 GO:0002688 regulation of leukocyte chemotaxis 8 6 2.95 47 0.03311 0.02887 GO:0006695 cholesterol biosynthetic process 8 6 2.95 48 0.03311 0.02887 GO:0042398 cellular modified amino acid biosyntheti... 8 6 2.95 49 0.03311 0.02887 GO:2001244 positive regulation of intrinsic apoptot... 8 6 2.95 50 0.03311 0.02887 GO:0002221 pattern recognition receptor signaling p... 10 7 3.69 56 0.03497 0.03006 GO:0002244 hematopoietic progenitor cell differenti... 10 7 3.69 57 0.03497 0.03006 GO:0002758 innate immune response-activating signal... 10 7 3.69 58 0.03497 0.03006 GO:0015909 long-chain fatty acid transport 10 7 3.69 59 0.03497 0.03006 PBMC_GO_Terms GO.ID Term Annotated Significant Expected Rank in classicFisher classicFisher elimFisher GO:0008150 biological_process 2819 924 940.65 5516 1 0.000000043 GO:0019229 regulation of vasoconstriction 11 9 3.67 3 0.00136 0.001 GO:0045668 negative regulation of osteoblast differ... 6 6 2 4 0.00137 0.0011 GO:0001756 somitogenesis 12 9 4 9 0.00382 0.0029 GO:0048820 hair follicle maturation 5 5 1.67 10 0.00411 0.0034 GO:0050877 neurological system process 165 69 55.06 26 0.01202 0.0048 GO:0007603 phototransduction, visible light 7 6 2.34 12 0.00684 0.0056 GO:0010389 regulation of G2/M transition of mitotic... 7 6 2.34 13 0.00684 0.0056 GO:0019915 lipid storage 11 8 3.67 19 0.00877 0.0069 GO:0048645 organ formation 11 8 3.67 20 0.00877 0.0069 GO:0050796 regulation of insulin secretion 24 14 8.01 23 0.01017 0.0072 GO:0042593 glucose homeostasis 31 17 10.34 24 0.01083 0.0073 GO:0044260 cellular macromolecule metabolic process 1065 373 355.37 198 0.08033 0.0077 GO:0006508 proteolysis 193 78 64.4 52 0.02022 0.008 GO:2000027 regulation of organ morphogenesis 36 19 12.01 27 0.01218 0.0081 GO:0060041 retina development in camera-type eye 20 12 6.67 33 0.01282 0.0094 GO:0007602 phototransduction 11 10 3.67 1 0.00013 0.0106 GO:0003214 cardiac left ventricle morphogenesis 4 4 1.33 28 0.01235 0.0107 GO:0016056 rhodopsin mediated signaling pathway 4 4 1.33 29 0.01235 0.0107 GO:0023019 signal transduction involved in regulati... 4 4 1.33 30 0.01235 0.0107 GO:0042640 anagen 4 4 1.33 31 0.01235 0.0107 GO:0050709 negative regulation of protein secretion 4 4 1.33 32 0.01235 0.0107 GO:0090304 nucleic acid metabolic process 676 242 225.57 180 0.069 0.0132 GO:0030326 embryonic limb morphogenesis 23 13 7.67 45 0.01841 0.0135 GO:0035113 embryonic appendage morphogenesis 23 13 7.67 46 0.01841 0.0135 GO:0042733 embryonic digit morphogenesis 14 9 4.67 38 0.01733 0.0136 GO:0044092 negative regulation of molecular functio... 141 58 47.05 66 0.02914 0.014 GO:0030198 extracellular matrix organization 45 22 15.02 55 0.02141 0.014 GO:0000041 transition metal ion transport 12 8 4 47 0.01867 0.0149 GO:0016070 RNA metabolic process 594 214 198.21 178 0.06801 0.015 GO:2000112 regulation of cellular macromolecule bio... 508 185 169.51 167 0.06058 0.0151 GO:0045931 positive regulation of mitotic cell cycl... 6 5 2 40 0.01782 0.0151 GO:0050912 detection of chemical stimulus involved ... 6 5 2 41 0.01782 0.0151 GO:0048736 appendage development 28 15 9.34 53 0.02124 0.0152 GO:0060173 limb development 28 15 9.34 54 0.02124 0.0152 GO:0050909 sensory perception of taste 8 6 2.67 50 0.01963 0.0163 GO:0035107 appendage morphogenesis 26 14 8.68 57 0.02445 0.0178 GO:0035108 limb morphogenesis 26 14 8.68 58 0.02445 0.0178 GO:0010467 gene expression 850 308 283.63 49 0.01951 0.0184 GO:0043062 extracellular structure organization 46 22 15.35 65 0.02844 0.0189 GO:0014074 response to purine-containing compound 17 10 5.67 60 0.02712 0.0211 GO:0051100 negative regulation of binding 17 10 5.67 61 0.02712 0.0211 GO:0051224 negative regulation of protein transport 17 10 5.67 62 0.02712 0.0211 GO:0010468 regulation of gene expression 581 208 193.87 224 0.09003 0.0222 GO:0030111 regulation of Wnt signaling pathway 42 20 14.01 102 0.03768 0.026 GO:0010605 negative regulation of macromolecule met... 268 101 89.43 171 0.06686 0.027 GO:0034645 cellular macromolecule biosynthetic proc... 638 226 212.89 449 0.11515 0.0281 GO:0051090 regulation of sequence-specific DNA bind... 58 26 19.35 119 0.04402 0.0287 GO:0006261 DNA-dependent DNA replication 11 7 3.67 104 0.03856 0.0318 GO:0009798 axis specification 11 7 3.67 105 0.03856 0.0318 Spleen_GO_Terms GO.ID Term Annotated Significant Expected Rank in classicFisher classicFisher elimFisher GO:0008150 biological_process 2819 836 848.26 5087 0.9999 0.000000083 GO:0010923 negative regulation of phosphatase activ... 5 5 1.5 1 0.0024 0.0021 GO:0071353 cellular response to interleukin-4 5 5 1.5 2 0.0024 0.0021 GO:0035909 aorta morphogenesis 4 4 1.2 4 0.0082 0.0072 GO:0060143 positive regulation of syncytium formati... 4 4 1.2 5 0.0082 0.0072 GO:0060260 regulation of transcription initiation f... 4 4 1.2 6 0.0082 0.0072 GO:0007423 sensory organ development 72 31 21.67 13 0.0124 0.0076 GO:0036293 response to decreased oxygen levels 34 17 10.23 10 0.0113 0.008 GO:0021879 forebrain neuron differentiation 8 6 2.41 11 0.0114 0.0096 GO:2000134 negative regulation of G1/S transition o... 8 6 2.41 12 0.0114 0.0096 GO:0016055 Wnt signaling pathway 62 27 18.66 14 0.016 0.0103 GO:0001666 response to hypoxia 33 16 9.93 15 0.0195 0.0143 GO:0030534 adult behavior 18 10 5.42 16 0.0211 0.0168 GO:0006396 RNA processing 108 42 32.5 32 0.029 0.017 GO:0043487 regulation of RNA stability 11 7 3.31 17 0.0218 0.0182 GO:0048585 negative regulation of response to stimu... 164 60 49.35 48 0.0392 0.0207 GO:0007612 learning 16 9 4.81 19 0.0258 0.021 GO:0043550 regulation of lipid kinase activity 9 6 2.71 18 0.0255 0.0217 GO:0006508 proteolysis 193 69 58.07 58 0.0466 0.0238 GO:0005981 regulation of glycogen catabolic process 3 3 0.9 20 0.0272 0.0247 GO:0007096 regulation of exit from mitosis 3 3 0.9 21 0.0272 0.0247 GO:0010971 positive regulation of G2/M transition o... 3 3 0.9 22 0.0272 0.0247 GO:0021889 olfactory bulb interneuron differentiati... 3 3 0.9 23 0.0272 0.0247 GO:0031935 regulation of chromatin silencing 3 3 0.9 24 0.0272 0.0247 GO:0035791 platelet-derived growth factor receptor-... 3 3 0.9 25 0.0272 0.0247 GO:0060968 regulation of gene silencing 3 3 0.9 26 0.0272 0.0247 GO:0060969 negative regulation of gene silencing 3 3 0.9 27 0.0272 0.0247 GO:0090308 regulation of methylation-dependent chro... 3 3 0.9 28 0.0272 0.0247 GO:1901741 positive regulation of myoblast fusion 3 3 0.9 29 0.0272 0.0247 GO:1902751 positive regulation of cell cycle G2/M p... 3 3 0.9 30 0.0272 0.0247 GO:0010389 regulation of G2/M transition of mitotic... 7 5 2.11 33 0.029 0.0253 GO:0014911 positive regulation of smooth muscle cel... 7 5 2.11 34 0.029 0.0253 GO:0090218 positive regulation of lipid kinase acti... 7 5 2.11 35 0.029 0.0253 GO:1902749 regulation of cell cycle G2/M phase tran... 7 5 2.11 36 0.029 0.0253 GO:0006699 bile acid biosynthetic process 5 4 1.5 38 0.031 0.0276 GO:0031529 ruffle organization 5 4 1.5 39 0.031 0.0276 GO:0032845 negative regulation of homeostatic proce... 5 4 1.5 40 0.031 0.0276 GO:0043277 apoptotic cell clearance 5 4 1.5 41 0.031 0.0276 GO:0045930 negative regulation of mitotic cell cycl... 5 4 1.5 42 0.031 0.0276 GO:0007050 cell cycle arrest 27 13 8.12 45 0.0361 0.028 GO:0051604 protein maturation 220 77 66.2 82 0.0589 0.0295 GO:0008380 RNA splicing 58 24 17.45 52 0.0428 0.0298 GO:0009887 organ morphogenesis 139 51 41.83 68 0.0518 0.0299 GO:0045087 innate immune response 67 27 20.16 57 0.0463 0.0315 GO:0006397 mRNA processing 73 29 21.97 67 0.048 0.0323 GO:0006487 protein N-linked glycosylation 12 7 3.61 46 0.0389 0.0328 GO:0045185 maintenance of protein location 17 9 5.12 49 0.0406 0.0333 GO:0045445 myoblast differentiation 17 9 5.12 50 0.0406 0.0333 GO:0007411 axon guidance 33 15 9.93 53 0.0439 0.0335 GO:0097485 neuron projection guidance 33 15 9.93 54 0.0439 0.0335