Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor

Data Supplement

Files in this Data Supplement:

• Supplemental Data -

  Supplemental Figure 1 - BRET Transient Transfection Titration Curves

  Supplemental Figure 2 - Ligand-induced Arrestin Recruitment

  Supplemental Figure 3 - G-protein and arrestin pathway bias plots

  Supplemental Table 1 - Selectivity data for novel compounds synthesized in this study

  Supplemental Table 2 - Published NOPR affinity and logEC50 data for NOPR activity