Supplemental File 2 Nexus format alignments for phylogenetic analyses 1) E(Spl)-C bHlH-orange domain genes #NEXUS BEGIN DATA; dimensions ntax=119 nchar=228; format missing=? interleave datatype=PROTEIN gap= -; matrix Aplahlhmgamma KVMKPMLERKRRARINRCLDELKELMVSALQS------------------ Ldechlhmbeta KVMKPMLERKRRARINRCLDELKELMVTALQS------------------ XP972685 KVMKPMLERKRRARINRCLDELKELMVTALQS------------------ Aglahlhmbeta KVMKPMLERKRRARINRCLDELKELMVTALQS------------------ Otauhlhmgamma KVMKPMLERKRRARINRCLDELKELMVTALQS------------------ Llon_2 KVMKPMLERKRRARINRCLDELKELMVTALQS------------------ CPIJ003409 KVMKPMLERKRRARINRCLDELKELMVSALQN------------------ AGAP012342 KVMKPMLERKRRARINRCLDELKELMVSALQS------------------ BMGA008965 KVMKPMLERKRRARINRCLDELKELMVSALQS------------------ Msex2.02580 KVMKPMLERKRRARINRCLDELKELMVSALQS------------------ EHJ69886.1 KVMKPMLERKRRARINRCLDELKELMVSALQS------------------ PHUM000172 KVMKPMLERKRRARINRCLDELKELMVAALQA------------------ Pvenhlhmgamma KVMKPMLERKRRARINRCLDELKELMVTALQS------------------ Hvithlhmbeta SVMKPMLERKRRARINRCLDELKELMVTALQA------------------ Focchlhmbeta KVMKPMLERKRRARINRCLDELKELMVGALTA------------------ KDR23061 KVMKPMLERKRRARINKCLDELKDLMVSALQA------------------ LFUL008934 KVMKPMLERKRRARINRCLDELKELMVGALAS------------------ GB43778 KVMKPMLERKRRARINRCLDELKDLMVTALAG------------------ Mrot882836 KVMKPMLERKRRARINRCLDELKDLMVTALAG------------------ SINV15880 KVMKPMLERKRRARINRCLDELKDLMVTALAG------------------ PB12775 KVMKPMLERKRRARINRCLDELKDLMVTALAG------------------ AECH21572 KVMKPMLERKRRARINRCLDELKDLMVTALAG------------------ ACEP15330 KVMKPMLERKRRARINRCLDELKDLMVTALAG------------------ Oabihlhmgamma KVMKPMLERKRRARINRCLDELKDLMVTALAG------------------ Aflo_59 KVMKPMLERKRRARINRCLDELKDLMVTALAG------------------ Aroshlhmbeta KVMKPMLERKRRARINRCLDELKDLMVSALAG------------------ Llun_hlhmbeta KVMKPMLERKRRARINRCLDELKELMVSALQA------------------ XP001946911 KVMKPMLERKRRARINRCLDELKELMVVALQN------------------ Mdes_X1_4_2 KVMKPMLERKRRARINRCLDELKELMVTALQA------------------ Hhal-1 -VMKPMLERKRRARINRCLDELKELMVSALQS------------------ OFAS011857 KVMKPMLERKRRARINRCLDELKELMVSALQS------------------ Edanhlhmbeta KVMKPMLERKRRARINRCLDELKELMVSALQH------------------ CLEC002262 KVMKPMLERKRRARINRCLDELKELMVTALQS------------------ LdecA006636 KVMKPMLERKRRARINRCLDELKDLMVSALAT------------------ GBUE006496 KVMKPMLERKRRARINRCLDELKELMVVALQA------------------ LFUL017858 KVMKPMLERKRRARINRCLDELKELMVGALAA------------------ FoccM004632 KVMKPMLERKRRARINRCLDELKELMVGALAS------------------ GB43788 KVMKPMLERKRRARINRCLDELKDLMVTALQA------------------ Mrot882729 KVMKPMLERKRRARINRCLDELKDLMVTALQA------------------ Aflo_46 KVMKPMLERKRRARINRCLDELKDLMVTALQA------------------ PB12783 KVMKPMLERKRRARINRCLDELKDLMVTALQA------------------ AECH21581 KVMKPMLERKRRARINRCLDELKDLMVTALQA------------------ ACEP15313 KVMKPMLERKRRARINRCLDELKDLMVTALQA------------------ SINV15898 KVMKPMLERKRRARINRCLDELKDLMVTALQA------------------ Arosespl_in_ttl KVMKPMLERKRRARINRCLDELKDLMVTALQA------------------ BMGA008915 KVMKPMLERKRRARINRCLDELKDLMVTALQA------------------ Msex2.02577 KVMKPMLERKRRARINRCLDELKDLMVTALQA------------------ Hmel2 KVMKPMLERKRRARINRCLDELKDLMVTALQA------------------ EHJ69429.1 K---PMLERKRRARINRCLDELKDLMVTALQA------------------ PHUM009020 KVMKPMLERKRRARINRCLDELKELMVAALQA------------------ XP972493 KVMKPMLERKRRARINRCLDELKELMVTALQS------------------ AglaA007570 KVMKPMLERKRRARINRCLDELKELMVTALQN------------------ AplaA001225 KVMKPMLERKRRARINRCLDELKELMVTALQS------------------ OtauA001741 KVMKPMLERKRRARINRCLDELKELMVSALQN------------------ XP001949114 KVMKPLLERKRRARINRCLDELKDLMVVTLQA------------------ KDR23063 KVMKPMLERKRRARINKCLDELKDLIVSSLQA------------------ NCBI228834 KVTKPLLERQRRARINRCLDELKDLMAGALAA------------------ HLHmbeta KVMKPMLERKRRARINKCLDELKDIMVECLTQ------------------ Ccaphlhmbeta KVMKPMLERKRRARINKCLDELKDIMVECLTQ------------------ Lcuphlhmbeta KVMKPMLERKRRARINKCLDELKDIMVECLTQ------------------ JGIV11299514 KVMKPMLERKRRARINRCLDELKELMSSALAS------------------ HLHmgamma KVMKPMLERKRRARINKCLDELKDLMVATLES------------------ LcupS1716_1 KVMKPMLERKRRARINKCLDELKDLMVATLES------------------ Ccaphlhmgamma KVMKPMLERKRRARINKCLDELKDLMVVTLES------------------ EaffA002154 KVMKPLLERKRRARINACLDELKDLMVFALQT------------------ EaffA002152 KVMKPLLERKRRARINACLDELKDLMVFALQT------------------ EaffA002149 KVMKPLLERKRRARINACLDELKDLMVFALQT------------------ Eaffhlhmbeta KIVKPLLERKRRARINACLDELKDLMVFALQT------------------ EaffA002146 KVMKPLLERKRRARINKCLDELKDLMVHALQH------------------ Mdes_5782 KVMKPMLERKRRARINRCLDELKELMTSALQT------------------ CLEC002260 KVMKPMLERKRRARINRCLDELKELMVTALQS------------------ EaffA002162 KITKPLLERKRRARINACLDELKDIMTVALQA------------------ EaffA002166 KITKPLLERKRRARINKCLDELKDIMTVALQA------------------ OFAS009677 KVMKPMLERKRRARINRCLDELKELMVSALQS------------------ EaffA002168 KVMKPMLERKRRARINKCLDELKDLMVSALQT------------------ GB43791 KITKPLLERKRRARINKCLDELKNLMIDALE------------------- Aflo_40 KITKPLLERKRRARINKCLDELKNLMIDALE------------------- Mrot882617 KITKPLLERKRRARINKCLDELKNLMIDALE------------------- AECH21585 KITKPLLERKRRARINRCLDELKDLMVDALE------------------- ACEP15314 KITKPLLERKRRARINRCLDELKDLMVDALE------------------- OabiM003770 -ITKPLLERKRRARINRCLEELKDLMVDALE------------------- ArosM004121 VITKPLLERKRRARINRCLDELKDLMVDALESATTLFFNVRWCNFTHTEH HvitM000199 -VTKPLLERKRRARINRCLDELKDLMMGALE------------------- KDR23064 KVTKPLLERKRRARINKCLDELKDLMVGALE------------------- FoccM004635 KVTKPLLERKRRARINRCLDELKELMVGALE------------------- XP001949200 KITKPLLERKRRARINRCLDELKDLMFSALE------------------- EdanM013391 KITKPLLERQRRARINRCLDELKELMVGALQ------------------- HLHm3 KVMKPLLERKRRARINKCLDDLKDLMVECLQ------------------- Ccaphlhm3 KVMKPLLERKRRARINKCLDDLKDLMVECLQ------------------- Lcuphlhm3 KVMKPLLERKRRARINKCLDDLKDLMVECLT------------------- Msex2.02576 KITKPLLERKRRARINRCLDELKDLMVGAL-------------------- Hmel1 KITKPLLERKRRARINRCLDELKDLMVGAL-------------------- EHJ69428.1 KITKPLLERKRRARINRCLDELKDLM------------------------ HLHm7 KVMKPLLERKRRARINKCLDELKDLMAECVAQ------------------ Lcuphlhm7 KVMKPLLERKRRARINKCLDDLKDLMAECFQS------------------ Ccap_espl2 KVMKPLLERKRRARINQCLDELKDLMAECVQQ------------------ NCBI234834 KITKPLLERQRRARINRCLDELKELMSAALAA------------------ EaffA002158 KVMKPLLERKRRARINKCLDELKELMMSALVE------------------ Smar_01651 KIVKPLLERRRRARINQCLMELKNLLRETNPSI----------------- Smar_10005 KIVKPLLERRRRARINQCLMELKNILRETNPSI----------------- Smar_00480 KVIKPLLEKRRRARINNCLTELKDLLVETYKN------------------ Smar_01368 KVIKPLLEKRRRARINNCLTELKDLLVETYKN------------------ HLHmdelta KVTKPLLERKRRARMNLYLDELKDLIVDTMDA------------------ Ccaphlhmdelta KVTKPLLERKRRARMNLYLDELKDLIVDTMEA------------------ LcupS1716_2 KVTKPLLERKRRARMNLYLEELKELIVDTMEQ------------------ Smar_01652 KMVKPILEKRRRARMNKSLDELKAYIVDVRKSEIS--------------- Ptep-hes1 RATKPIMEKRRRARINQCLSELKTLILDALNKDPSRH------------- LHES005588 RATKPIMEKRRRARINQCLSELKTLILDALNKDPSRH------------- h RSNKPIMEKRRRARINNCLNELKTLILDATKKDPARH------------- HLHm5 KVKKPLLERQRRARMNKCLDTLKTLVAEF--------------------- Ccaphlhm5 KVKKPLLERQRRARINKCLDTLKTLVAEF--------------------- Espl KVKKPMLERQRRARMNKCLDNLKTLVAEL--------------------- LcupA008816 KVKKPMLERQRRARMNKCLDQLKELVAEL--------------------- LcupA008817 KVKKPMLERQRRARMNKCLDQLKELVAEF--------------------- Lcuphlhm5 KVKKPMLERQRRARMNKCLDTLKELIAEF--------------------- Lcupe_spl_ KIKKPLLERQRRARINKCLDGLKQLMVDL--------------------- Ccap_espl1 KVKKPLLERQRRARINKCLEALKKLVAEL--------------------- ISCW013710 -VSKPLMEKRRRARINRCLSQLKALLVDSSKPESPRH------------- Her EVFKPMMERKRRSRINRCLDFIKDLLQEV--------------------- Aplahlhmgamma -----------------------------E-GE-NVSKLEKADILELTVR Ldechlhmbeta -----------------------------E-GE-NVSKLEKADILELTVR XP972685 -----------------------------E-GE-NVSKLEKADILELTVR Aglahlhmbeta -----------------------------E-GE-NVSKLEKADILELTVR Otauhlhmgamma -----------------------------E-GE-NVSKLEKADILELTVR Llon_2 -----------------------------E-GE-NVSKLEKADILELTVR CPIJ003409 -----------------------------E-GE-NVSKLEKADILELTVR AGAP012342 -----------------------------E-GE-NVAKLEKADILELTVR BMGA008965 -----------------------------E-GE-NVAKLEKADILELTVR Msex2.02580 -----------------------------E-GE-NVAKLEKADILELTVR EHJ69886.1 -----------------------------E-GE-NVAKLEKADILELTVN PHUM000172 -----------------------------E-GE-NVSKLEKADILELTVS Pvenhlhmgamma -----------------------------E-GE-NVSKLEKADILELTVQ Hvithlhmbeta -----------------------------E-GE-NVSKLEKADILELTVQ Focchlhmbeta -----------------------------E-GE-NVSKLEKADILELTVR KDR23061 -----------------------------E-GE-NVSKLEKADILELTVR LFUL008934 -----------------------------E-GE-NVSKLEKADILELTVR GB43778 -----------------------------D-GE-NVAKLEKADILELTVR Mrot882836 -----------------------------D-GE-NVAKLEKADILELTVR SINV15880 -----------------------------D-GE-NVAKLEKADILELTVR PB12775 -----------------------------D-GE-NVAKLEKADILELTVR AECH21572 -----------------------------D-GE-NVAKLEKADILELTVR ACEP15330 -----------------------------D-GE-NVAKLEKADILELTVR Oabihlhmgamma -----------------------------D-GE-NVAKLEKADILELTVR Aflo_59 -----------------------------D-GE-NVAKLEKADILELTVR Aroshlhmbeta -----------------------------D-GE-NVAKLEKADILELTVR Llun_hlhmbeta -----------------------------E-GE-NVAKLEKADILELTVR XP001946911 -----------------------------E-GE-NVSKLEKADILELTVR Mdes_X1_4_2 -----------------------------E-GE-NVSKLEKADILELTVR Hhal-1 -----------------------------D-GE-NVAKLEKADILELTVR OFAS011857 -----------------------------D-GE-NVAKLEKADILELTVR Edanhlhmbeta -----------------------------E-GE-NVNKLEKADILELTVR CLEC002262 -----------------------------E-GE-NVSKLEKADILELTVQ LdecA006636 -----------------------------D-GD-NVSKLEKADILELTVS GBUE006496 -----------------------------E-GE-NVSKLEKADILELTVR LFUL017858 -----------------------------E-GE-NVSKLEKADILELTVR FoccM004632 -----------------------------E-GE-NVSKLEKADILELTVR GB43788 -----------------------------E-GE-NVAKLEKADILELTVR Mrot882729 -----------------------------E-GE-NVAKLEKADILELTVR Aflo_46 -----------------------------E-GE-NVAKLEKADILELTVR PB12783 -----------------------------E-GE-NVAKLEKADILELTVR AECH21581 -----------------------------E-GE-NVAKLEKADILELTVR ACEP15313 -----------------------------E-GE-NVAKLEKADILELTVR SINV15898 -----------------------------E-GE-NVAKLEKADILELTVR Arosespl_in_ttl -----------------------------E-GE-NVAKLEKADILELTVR BMGA008915 -----------------------------E-GE-NVSKLEKADILELTVR Msex2.02577 -----------------------------E-GE-NVSKLEKADILELTVR Hmel2 -----------------------------E-GE-NVSKLEKADILELTVR EHJ69429.1 -----------------------------E-GE-NVSKLEKADILELTVR PHUM009020 -----------------------------E-GE-NVSKLEKADILELTVN XP972493 -----------------------------E-GE-NVSKLEKADILELTVR AglaA007570 -----------------------------E-GE-NVSKLEKADILELTVR AplaA001225 -----------------------------E-GE-NVSKLEKADILELTVR OtauA001741 -----------------------------E-GE-NVSKLEKADILELTVR XP001949114 -----------------------------E-GE-NVSKLEKADILELTVR KDR23063 -----------------------------E-GE-NVSKLEKADILELTVR NCBI228834 -----------------------------EHGEAGMAKLEKADVLELTVR HLHmbeta -----------------------------E-GE-HITRLEKADILELTVE Ccaphlhmbeta -----------------------------E-GE-HITRLEKADILELTVE Lcuphlhmbeta -----------------------------E-GE-HITRLEKADILELTVE JGIV11299514 -----------------------------E-GE-NLTKLEKADVLELTVR HLHmgamma -----------------------------E-GE-HVTRLEKADILELTVT LcupS1716_1 -----------------------------E-GE-HVTRLEKADILELTVS Ccaphlhmgamma -----------------------------E-GE-HVTRLEKADILELTVA EaffA002154 -----------------------------E-GE-SISKLEKADVLELTVR EaffA002152 -----------------------------E-GE-SISKLEKADVLELTVR EaffA002149 -----------------------------E-GE-SISKLEKADVLELTVR Eaffhlhmbeta -----------------------------E-GE-SISKLEKADVLELTVR EaffA002146 -----------------------------E-GE-NITKLEKADVLELTVR Mdes_5782 -----------------------------E-GE-NVAKLEKADILELTVR CLEC002260 -----------------------------E-GE-NVSKLEKADILELTVR EaffA002162 -----------------------------E-GE-NVSKLEKADILELTVR EaffA002166 -----------------------------E-GE-NVSKLEKADILELTVR OFAS009677 -----------------------------D-GE-NVAKLEKADILELTVR EaffA002168 -----------------------------E-GE-SITKLEKADVLELTVR GB43791 -----------------------------TEGE-DISKLEKADILELTVR Aflo_40 -----------------------------TEGE-DISKLEKADILELTVR Mrot882617 -----------------------------TEGE-DISKLEKADILELTVR AECH21585 -----------------------------TEGE-NISKLEKADILELTVR ACEP15314 -----------------------------TEGE-NISKLEKADILELTVR OabiM003770 -----------------------------TEGE-NISKLEKADVLELTVR ArosM004121 PRAERKFLVFKVRIIPRILYSVYLKPETPTEGE-NISKLEKADILELTVR HvitM000199 -----------------------------AEGE-NVNKLEKADILELTVK KDR23064 -----------------------------AEGE-NVSKLEKADILELTVQ FoccM004635 -----------------------------AEGE-NVSKLEKADILELTVR XP001949200 -----------------------------AEGE-NVDKLEKADILEFTVK EdanM013391 ----------------------------------NINKLEKADILELTVR HLHm3 -----------------------------QEGE-HVTRLEKADILELTVD Ccaphlhm3 -----------------------------QEGE-HVTRLEKADILELTVE Lcuphlhm3 -----------------------------QEGE-HVTRLEKADILELTVE Msex2.02576 -----------------------------EIDDDNLSKLEKADILELTVN Hmel1 -----------------------------EIDDDNLSKLEKADILELTVN EHJ69428.1 ------------------------------IDDDNLSKLEKADILELTVN HLHm7 ------------------------------TGD--A-KFEKADILEVTVQ Lcuphlhm7 ------------------------------NGENNV-KFEKADILEVTVQ Ccap_espl2 -----------------------------QSGDAEV-KLEKADILELTVE NCBI234834 ------------------------------EGE-NLTKLEKADVLELTVR EaffA002158 -----------------------------ENGE-NSSKLEKADILEVTVN Smar_01651 -----------------------------DNNEAN--RLEKADILELTVR Smar_10005 -----------------------------DNDEAN--RLEKADILELTVR Smar_00480 -----------------------------DISEPS--KLEKADILELTVR Smar_01368 -----------------------------DITEPS--KLEKADILELTVR HLHmdelta ------------------------------QGE-QVSKLEKADILELTVN Ccaphlhmdelta ------------------------------QGE-HIAKLEKADILELTVN LcupS1716_2 ------------------------------QGE-HVNKLEKADILEMTVS Smar_01652 ----------------------------------DPSKLEKADILEHTVH Ptep-hes1 ------------------------------------SKLEKADILEMTVR LHES005588 ------------------------------------SKLEKADILEMTVR h ------------------------------------SKLEKADILEKTVK HLHm5 ------------------------------QGDDAILRMDKAEMLEAALV Ccaphlhm5 ------------------------------QGDDAILRMDKAEMLESTIA Espl ------------------------------RGDDGILRMDKAEMLESAVI LcupA008816 ------------------------------QGNDAILRMDKAEMLECALT LcupA008817 ------------------------------QGNDAILRMDKAEMLECALT Lcuphlhm5 ------------------------------QGNDAILRMDKAEMLESALE Lcupe_spl_ ------------------------------NGNSKILRMDKAEMLETTIV Ccap_espl1 ------------------------------QADDAVLRMDKAELLEQTLV ISCW013710 ------------------------------------ARLEKADILEMTVN Her ---------------------------SHLDGE-TMAKMDMGDVLELAVH Aplahlhmgamma HLHKLR--------RQQRLAAN----P---------VIDADRFR------ Ldechlhmbeta HLHKLR--------RQQRLSTN----P---------VIDADRFR------ XP972685 HLHKLR--------RQQRLSAN----P---------VVDADRFR------ Aglahlhmbeta HLHKLR--------RQQRLSTN----P---------VIDADRFR------ Otauhlhmgamma HLHKLR--------RQQRLSAN----P---------VIEADRFR------ Llon_2 HLHKLR--------RQQRLCAN----P---------VIDSDRFR------ CPIJ003409 HLHKLR--------RQQRLAVN----P---------VIDADRFR------ AGAP012342 HLHKLR--------RQQRLAAN----P---------VLDADRFR------ BMGA008965 HLHKLR--------RQRRLSLN----P---------TVDVDRFR------ Msex2.02580 HLHKLR--------RQRRLSLN----P---------TVDVDRFR------ EHJ69886.1 HLHKLR--------RQRRLSLN----S---------TVDTDRFR------ PHUM000172 HLHKLR--------RQQRLASN----P---------VTDADRFR------ Pvenhlhmgamma HLQKVR--------RQQRLASN----P---------VTDADRFR------ Hvithlhmbeta HLHKLR--------RQQRLAAN----P---------VTDADRFR------ Focchlhmbeta HLHRLR--------REQRLAAN----P---------VTDADRFR------ KDR23061 YLHKLR--------RQQRLSAN----P---------VTDADRFR------ LFUL008934 HLHRLR--------RTQRLAAAC---P---------TADADRFR------ GB43778 HLHKLQ--------RQQRLSAN----P---------VIDADRFR------ Mrot882836 HLHKLQ--------RQQRLSAN----P---------VIDADRFR------ SINV15880 HLHKLQ--------RQQRLSAN----P---------VIDADRFR------ PB12775 HLHKLQ--------RQQRLSAN----P---------VIDADRFR------ AECH21572 HLHKLQ--------RQQRLSAN----P---------VIDADRFR------ ACEP15330 HLHKLQ--------RQQRLSAN----P---------VIDADRFR------ Oabihlhmgamma HLHKLQ--------RQQRLSAN----P---------VIDADRFR------ Aflo_59 HLHKLQ--------RQQRLSAN----P---------VIDADRFR------ Aroshlhmbeta HLHKLQ--------RQQRLSAN----P---------VIDADRFR------ Llun_hlhmbeta HLRGLR--------R------------------------ADRFR------ XP001946911 HLHKLR--------RQQRLSGN----P---------VTEMDRFR------ Mdes_X1_4_2 HLHKLK--------RQQRLAAN----P---------VIEADRFR------ Hhal-1 HLHKLR--------KARRLSL---------------TATDDRFR------ OFAS011857 HLHKLR--------KARRLTLGP---QQ-SPTPAPLSPTDDRFR------ Edanhlhmbeta HLHRLR--------RQQRLSANP-------------ATDSDRYR------ CLEC002262 HLHKLR--------KAKKLCLTG---GE----------KEDKFR------ LdecA006636 HLQKLK--------RQQRLSVNP-------------VVEADRFR------ GBUE006496 HLHKLK--------KESRL----------------VVQDSDRFR------ LFUL017858 HLHRLR--------RTQRLALTP---E---------AAYADRFR------ FoccM004632 HLHNLR--------RQRALGLTP---ES-AY--------ADRFR------ GB43788 HLHTLR--------AARRLTLTP---EN-SY--------ADRFR------ Mrot882729 HLHTLR--------DARRLTLTP---EN-SY--------ADRFR------ Aflo_46 HLHTLR--------AARRLTLTP---EN-SY--------ADRFR------ PB12783 HLHTLR--------AARRLTLTP---EN-SY--------ADRFR------ AECH21581 HLHTLR--------AARRLTLTP---EN-SY--------ADRFR------ ACEP15313 HLHTLR--------AARRLTLTP---EN-SY--------ADRFR------ SINV15898 HLHTLR--------AARRLTLTP---EN-SY--------ADRFR------ Arosespl_in_ttl HLHTLR--------AARRLTLTP---ET-SY--------ADRFR------ BMGA008915 HLHNLK--------QRGQLVVKP---EM-SY--------TERFR------ Msex2.02577 HLHNLK--------RRGQLVLKP---EM-SY--------AERFR------ Hmel2 HLHSLK--------RKGQLVLKP---EM-SY--------AERFR------ EHJ69429.1 HLHSLK--------RRGQLVLKP---EM-SY--------AERFR------ PHUM009020 HLQKLR--------KQHTMNVSR---DT-SY--------AERFR------ XP972493 HLHGLK--------RQHQLVIPP---E--GY--------ADRFR------ AglaA007570 HLHSLK--------RQHQLVLPP---EQ-SY--------ADRFR------ AplaA001225 HLHNLK--------RQHQLILPS---EQ-SY--------ADRFR------ OtauA001741 HLHNLK--------RQHQLVVTT---DS-SY--------ADRFK------ XP001949114 HLHKLK--------RHNALGLTG---VD-SVY-------ADKFR------ KDR23063 HLHKLR--------RQHSLGLNP---EV-AY--------ADRFR------ NCBI228834 HLHKLR--------RERRLAANP-------------VVASDRFR------ HLHmbeta HMKKLR--------AQKQLRLSSVTGGV-SPSADPKLSIAESFR------ Ccaphlhmbeta HMKKLR--------AQKQLRLGGVGAGT-GAVQDPKLTIAESFR------ Lcuphlhmbeta HMKKLR--------AQKQLRLNG--------NPDSKLTIAESFR------ JGIV11299514 HLHKLR--------ERQALGLSP--SPS-SPGSPNSNNSQDKFR------ HLHmgamma HLQKMK--------QQRQHKRASGDESL-T--------PAEGFR------ LcupS1716_1 HLQKMK--------QQRKLSSSSGNTTM-N--------QAEGFR------ Ccaphlhmgamma HLQKLK--------QQRKAAASKGG-AM-S--------QAEGFR------ EaffA002154 HLRKLK--------RQQMLALNPG-------------LDLDRFH------ EaffA002152 HLRKLK--------RQQMLALNPG-------------LDLDRFH------ EaffA002149 HLRKLK--------RQQMLALNPG-------------LDLDRFH------ Eaffhlhmbeta HLRKLK--------RQQMLALNPG-------------LDLDRFH------ EaffA002146 HLRKLK--------RQQMLALNPG-------------LDLDRFH------ Mdes_5782 HLHSLR--------RQNGLSTRSENSY------------AEKFK------ CLEC002260 HLQSLR--------RVEQ--------------------GGNRYE------ EaffA002162 HLQKLN--------QSHRLTIR------------NPIEELQKFQ------ EaffA002166 HLHKLS--------QSRRLMVR------------NPLEDLQKFQ------ OFAS009677 HLQRLS--------RES----GPGGLSL-QQPGKQQPAGDDRYS------ EaffA002168 HLRKLK--------AQGGLSLTNSG--------------SERFR------ GB43791 HLQRL----------QGSRSSTGH-LLD-TATKSGEVSGENRWL------ Aflo_40 HLQRL----------QSSRSSTG--LPD-TATKNDEVSAENRWL------ Mrot882617 HLQRL----------QGSQPSV---LPA-TMANNAEVSAESRWL------ AECH21585 HLQKL----------QASRPS--G-LSV-TIASGDEISAESRWQ------ ACEP15314 HLQKL----------QASRPS--G-LSV-TIASGDEISAESRWQ------ OabiM003770 HLQRL----------QASRPS--G-LSA-QASPGDE-SAESRWQ------ ArosM004121 HLQRL----------QASRPS--G-LSS-SAIPGED-SSESRWR------ HvitM000199 HLHRI-------------------------TRPRDAAEDVHRFQISVAKL KDR23064 HLHRL-------------------------RRPRDAAEDAHRFQ------ FoccM004635 HLQRI-------------------------TRPRDVAEDASRFQ------ XP001949200 HLQKI-------------------------TR-RDLVEEAYKFQ------ EdanM013391 HLHRLH--------QQGLAGGAPD-LPA-GAQPAPVQDPVHRFQ------ HLHm3 HMRKLK--------QRGGLSLQGVVAGVGSPPTSTSTAHVESFR------ Ccaphlhm3 HMRKLK--------QRGSLSLQ-----------SQASAHIESFR------ Lcuphlhm3 HMRKLK--------QRGNLALR----------TTTLNAHVESFR------ Msex2.02576 HLTKLH--------SPK-----------------DPVVEAKKFQ------ Hmel1 HLTKLH--------RPK-----------------DPVLEAKKFQ------ EHJ69428.1 HLTKLH--------RPK-----------------DPVMEAKKFQ------ HLHm7 HLRKLK--------ESKKHVPAN---P------------EQSFR------ Lcuphlhm7 HLRKLK--------QQKEQIAHNNVAA------------QQSFR------ Ccap_espl2 HLRKMR--------QHQKKAKHIDDDV------------RQSFR------ NCBI234834 HLHQLH--------REGELSLNAVGG------------------GGGGIF EaffA002158 YLNKLK--------NSDSLVLTPS------------VTYSHRFR------ Smar_01651 QLKGLQ--------LQRRV----HQ------------VDVAEFR------ Smar_10005 QLKGLR--------LQRSVI---HR------------VDVAEFR------ Smar_00480 HLRELR--------QQRRVIVSTRR------------NDANDFR------ Smar_01368 HLRELR--------QQQRVIVTTRR------------TDANDFR------ HLHmdelta YLKA----------QQQQRVANPQSPPPDQ-------VNLDKFR------ Ccaphlhmdelta YLRTHKHEIAASVVQQQQNAANA-SGDTTG-------INVEKFR------ LcupS1716_2 YLRNQKGAGA------NETTTNDLTKRP---------LNVEKFR------ Smar_01652 HLRDLRRQQ-----QQRGMAVTNGAV-------------ASRF------- Ptep-hes1 HLQNIQRQQMATAISTDSSVLN-------------------KFK------ LHES005588 HLQNIQRQQMASAISTDSSVLN-------------------KFK------ h HLQELQRQQAAMQQAADPKIVN-------------------KFK------ HLHm5 FMRKQVVKQQAP---VSPL-P------------------MDSFKN----- Ccaphlhm5 FMRQHSRRQRTTMPAVAPLAP------------------MDGFRN----- Espl FMRQQKTPKKVAQEEQS--LP------------------LDSFKN----- LcupA008816 FIKKEVKKPIVP----A-VIP------------------MDSFRH----- LcupA008817 FIKKEVKKPIVP----A-VIP------------------MDSFRH----- Lcuphlhm5 FMKVECKKPIQPISKIA-VAP------------------MDSFRN----- Lcupe_spl_ YLRQHVKQQKMQ----TQQIP------------------MDSFRN----- Ccap_espl1 FVRQQCANNSRKPQKNTQTSA-------------------DSFRN----- ISCW013710 HLQALHRQRRTVPFTMN-----------------------PAHEYMSLAA Her HLSKKNCPVATPTTAPTS-------------------------------- Aplahlhmgamma ----------------------AGFTHCANEVSRCLA--SI----P---- Ldechlhmbeta ----------------------AGYTHCANEVSRCLA--GT----P---- XP972685 ----------------------AGYTHCANEVSRCLA--SI----P---- Aglahlhmbeta ----------------------AGYTHCANEVSRCLA--AI----P---- Otauhlhmgamma ----------------------AGYTHCANEVSRCLA--SI----P---- Llon_2 ----------------------AGFTHAANEVSRCLA--ST----P---- CPIJ003409 ----------------------AGFTHAANEVSRCLA--ST----S---- AGAP012342 ----------------------AGFTHAANEVSRCLA--ST----P---- BMGA008965 ----------------------AGFTHAANEVSRCLA--SI----P---- Msex2.02580 ----------------------AGFTHAANEVSRCLA--SI----P---- EHJ69886.1 ----------------------AGFTHAANEVSRCLA--SI----P---- PHUM000172 ----------------------AGFTHCATEVSRCLA--AT----P---- Pvenhlhmgamma ----------------------AGFTHCANEVSKCLA--AT----P---- Hvithlhmbeta ----------------------AGFTHCATEVSRCLA--ST----P---- Focchlhmbeta ----------------------AGFTHCATEVSRCLA--AT----P---- KDR23061 ----------------------AGFTHCATEVSRCLA--AT----P---- LFUL008934 ----------------------AGFTHCAAEVSRCLA--AT----P---- GB43778 ----------------------AGYTHCANEVSRCLA--AT----P---- Mrot882836 ----------------------AGYTHCANEVSRCLA--AT----P---- SINV15880 ----------------------AGYTHCANEVSRCLA--AT----P---- PB12775 ----------------------AGYTHCANEVSRCLA--AT----P---- AECH21572 ----------------------AGYTHCANEVSRCLA--AT----P---- ACEP15330 ----------------------AGYTHCANEVSRCLA--AT----P---- Oabihlhmgamma ----------------------AGYTHCANEVSRCLA--AT----P---- Aflo_59 ----------------------AGYTHCANEVSRCLA--AT----P---- Aroshlhmbeta ----------------------AGYTHCANEVSRCLA--AT----P---- Llun_hlhmbeta ----------------------AGFTHAAAEVSRCLA--ST----P---- XP001946911 ----------------------AGYTRCASEVSRCLA--AT----P---- Mdes_X1_4_2 ----------------------AGFTQAANEVSRVLA--ST----P---- Hhal-1 ----------------------AGYTHCAGEVSKCLA--ST----P---- OFAS011857 ----------------------AGYTHCASEVSKCLA--AT----P---- Edanhlhmbeta ----------------------AGFTHCAAEVSRCLA--TV----P---- CLEC002262 ----------------------AGYTHCANEVSRCLA--ST----P---- LdecA006636 ----------------------AGFTTCAKEVSKCLA--ST----P---- GBUE006496 ----------------------DGYTHCANEVSKYLA--GV----P---- LFUL017858 ----------------------AGFSHCAAEVSRYLG--AV----TSANG FoccM004632 ----------------------AGFTHCAAEVNNYLTVHAV----P---- GB43788 ----------------------EGFTQCAQEVSSFLST-PVAAA------ Mrot882729 ----------------------EGFTQCAQEVSSFLST-PVAAA------ Aflo_46 ----------------------EGFTQCAQEVSSFLST-PVAAA------ PB12783 ----------------------DGFTQCAQEVSTFLST-PVAAA------ AECH21581 ----------------------DGFTQCAQEVSTFLST-PVAAA------ ACEP15313 ----------------------DGFTQCAQEVSTFLST-PVAAA------ SINV15898 ----------------------DGFTQCAQEVSTFLST-PVAAT------ Arosespl_in_ttl ----------------------DGFTQCAQEVSTFLST-PVAAS------ BMGA008915 ----------------------AGFTQCATEVSQFIAN-ATLAANAMQRQ Msex2.02577 ----------------------AGFTQCATEVSQFIAN-ATLAANAMQRQ Hmel2 ----------------------AGFAQCATEVSQFITN-ATVAANAMHRQ EHJ69429.1 ----------------------AGFAQCATEVSQFITS-ATVAANAMQRQ PHUM009020 ----------------------AGFTQCAAEVSTYLATLPIAAA------ XP972493 ----------------------AGFTQCAQEVSQFLTTPTET-------- AglaA007570 ----------------------AGFTQCAQEVTHFITTPTEI-------- AplaA001225 ----------------------AGFTHCAQEVSQFLSSPKDC-------- OtauA001741 ----------------------AGFSQCAQEVSHFIAAPTKL-------- XP001949114 ----------------------AGFAHCATEVSNYLTSDV--------RS KDR23063 ----------------------AGFTHCAAEVSQYLAAAATSPTSPLN-- NCBI228834 ----------------------AGFTQCAREVSVALAAIP---------- HLHmbeta ----------------------AGYVHAANEVSKTLAAVP---------- Ccaphlhmbeta ----------------------AGYVHAANEVSKTLAALP---------- Lcuphlhmbeta ----------------------AGYIHAANEVSKTLATVP---------- JGIV11299514 ----------------------AGFTHCAAEVSRYLATST---------- HLHmgamma ----------------------SGYIHAVNEVSRSLSQLP---------- LcupS1716_1 ----------------------SGYIHAVNEVSKSLSELP---------- Ccaphlhmgamma ----------------------SGYIHAVNEVSRSLSQLP---------- EaffA002154 ----------------------AGYTACATEVSKCLAS-T---------- EaffA002152 ----------------------AGYTACATEVSKCLAS-T---------- EaffA002149 ----------------------AGYTACATEVSKCLAS-T---------- Eaffhlhmbeta ----------------------AGYTACATEVSKCLAS-T---------- EaffA002146 ----------------------AGYTACATEVNRCMSNIS---------- Mdes_5782 ----------------------AGFRHCAAEVSNFMGV------------ CLEC002260 ----------------------EGWSACLEQVTRFLR----------EGK EaffA002162 ----------------------AGYSSCAQEATSFLLSAP---------- EaffA002166 ----------------------AGYSSCAQEAATFLLSTP---------- OFAS009677 ----------------------EGWASCLKEVAAYLG------------G EaffA002168 ----------------------SGFRLCVGEITRFVTSGT---------- GB43791 ----------------------SGFGHCAAEAYRFLSAVP---------- Aflo_40 ----------------------SGFGHCAAEAYRFLSAVP---------- Mrot882617 ----------------------SGFGHCAAEAYRFLSALP---------- AECH21585 ----------------------SGFGHCAAEAYRFLSSLP---------- ACEP15314 ----------------------SGFGHCAAEAYRFLSSLP---------- OabiM003770 ----------------------SGFGHCAAEACRFLSALP---------- ArosM004121 ----------------------SGFGHCAAEACRFLTALP---------- HvitM000199 YQISDSDYVFSWKVYDLHCLLQAGFSQCASEACGFLLSLP---------- KDR23064 ----------------------AGFSQCASEACQFLLSLP---------- FoccM004635 ----------------------AGFSQCASEACHFLLGLP---------- XP001949200 ----------------------EGFSHCASEACSFLLSLP---------- EdanM013391 ----------------------AGFSHCASEACHFLLGLP---------- HLHm3 ----------------------SGYVHAADQITQVLL------------Q Ccaphlhm3 ----------------------SGYVHAADQISQVLL------------Q Lcuphlhm3 ----------------------SGYVHAADQISQVLL------------Q Msex2.02576 ----------------------AGFGHCAAEACRFIMSVP---------- Hmel1 ----------------------AGFGQCAAEACRFIMSVP---------- EHJ69428.1 ----------------------AGFGQCAAEACRFIMSVP---------- HLHm7 ----------------------AGYIRAANEVSRALASLP---------- Lcuphlhm7 ----------------------SGYIQAANEVSRCMASLP---------- Ccap_espl2 ----------------------SGYIKAAHEISRCLATLP---------- NCBI234834 NRPPSAAAAAVAAAPADRRRYQGGFIACAQQVASYVMKTP---------- EaffA002158 ----------------------SGFSACASEVARFLST----------PG Smar_01651 ----------------------AGFTECANEVAMCVTTLP---------- Smar_10005 ----------------------AGFTECANEVAVCVTTLP---------- Smar_00480 ----------------------AGYSECAGEVAACLGNMP---------- Smar_01368 ----------------------VGYNECASEVAACLGNMP---------- HLHmdelta ----------------------AGYTQAAYEVSHIFSTVP---------- Ccaphlhmdelta ----------------------AGYTQAAYEVSRVFATVP---------- LcupS1716_2 ----------------------EGYTQAAYEVSKVFSTVP---------- Smar_01652 ---------------------GAGFTECANEVSVYLSTLP---------- Ptep-hes1 ----------------------AGFNECATEVTRYVNRIE---------- LHES005588 ----------------------AGFNECATEVTRYVSRIE---------- h ----------------------AGFADCVNEVSRF----P---------- HLHm5 -----------------------GYMNAVSEISRVMACTP---------- Ccaphlhm5 -----------------------GYMNAVNEVSRVMAAMP---------- Espl -----------------------GYMNAVNEVSRVMASTP---------- LcupA008816 -----------------------GYMNAVNEVSRVMAATP---------- LcupA008817 -----------------------GYMNAVNEVSRVMAATP---------- Lcuphlhm5 -----------------------GYMNAVNEVSRVMAGTP---------- Lcupe_spl_ -----------------------GYMNAVNEVSRVLASTP---------- Ccap_espl1 -----------------------GYMNAVNEVSLVMASTS---------- ISCW013710 LTCNSACPARLLDDSEVRHKFRAGYEECILETRRFLCSLADRQLLTNSGA Her -----------GVYQSPIDCYWSGFRECVLEVSQFL-------------- Aplahlhmgamma -GVDIQLGTKLMTHLGHRLNEM------ Ldechlhmbeta -GVDIQLGTKLMTHLGHRLNEM------ XP972685 -HVDVQLGTKLMTHLGHRLNEM------ Aglahlhmbeta -GVDVQLGTKLMTHLGHRLNDM------ Otauhlhmgamma -GVDVGLGTKLMTHLGLRLNEM------ Llon_2 -GVDVTLGTKLMTHLGHRLNEL------ CPIJ003409 -GVDIKLGTKLMTHLGHRLNDL------ AGAP012342 -GVDIKLGTKLMTHLGHRLNDL------ BMGA008965 -GVDVRLGTQLMTHLGHRLNEM------ Msex2.02580 -GVDVRLGTQLMTHLGHRLNDM------ EHJ69886.1 -GVDVRLGTQLMTHLGHKLNDI------ PHUM000172 -GIDIKLGTKLMTHLGHRLNDM------ Pvenhlhmgamma -GIDLRLGTKLMSHLGQRLNDM------ Hvithlhmbeta -GVDVRLGTKLMTHLGHRLNEM------ Focchlhmbeta -GVDVQLGTTLMTHLGHRLNEM------ KDR23061 -GVDVKLGTKLMTHLGHRLNDM------ LFUL008934 -GVDVRLGTMLMTHLGHRLNDL------ GB43778 -GVDVALGTKLMTHLGHKLNSM------ Mrot882836 -GVDVALGTKLMTHLGHKLNSM------ SINV15880 -GVDVALGTKLMTHLGHKLNSM------ PB12775 -GVDVALGTKLMTHLGHKLNSM------ AECH21572 -GVDVALGTKLMTHLGHKLNSM------ ACEP15330 -GVDVALGTKLMTHLGHKLNSM------ Oabihlhmgamma -GVDVALGTKLMTHLGHKLNSM------ Aflo_59 -GVDVALGTKLMTHLGHKLNSM------ Aroshlhmbeta -GVDIALGTKLMTHLGHKLNAM------ Llun_hlhmbeta -GVDVALGTRLMTHLGHRLNRL------ XP001946911 -GLDVTLGANLMTHLGHRLNSI------ Mdes_X1_4_2 -NVDVTLGKRIMSHLGHRINDL------ Hhal-1 -GVDVRLGTKLMSHLGHRLNEL------ OFAS011857 -GVDVRLGTKLMTHLGHRLNEL------ Edanhlhmbeta -GVDVDLGTRLMTHLGHRLNDM------ CLEC002262 -GVDVRLGTQLMSHLGHRLNEI------ LdecA006636 -GVDVHLGTKLMTHLGHSLKGM------ GBUE006496 -GVDVVLGKQLMSHLGLRLNEL------ LFUL017858 GGVEAHVGARLLTHLGHCLQNI------ FoccM004632 -AVDRSTSAKLLQHLGTCIRKI------ GB43788 --VHPAAGAQLMRHLGGCLRRL------ Mrot882729 --VHPAAGAQLMRHLGGCLRRL------ Aflo_46 --VHPAAGAQLMRHLGGCLRRL------ PB12783 --VHPAAGAQLMRHLGGCLRRL------ AECH21581 --VHPAAGAQLMRHLGGCLRRL------ ACEP15313 --VHPAAGAQLMRHLGGCLRRL------ SINV15898 --VHPAAGAQLMRHLGGCLRRL------ Arosespl_in_ttl --VHPAAGAQLMRHLGGCLRRL------ BMGA008915 GPVDPQAGARLLQHLSNCIRRL------ Msex2.02577 GPVDPQAGARLLQHLSNCIRRL------ Hmel2 GPVDPQAGARLLQHLSNCIRRL------ EHJ69429.1 GPVDPQAGARLLQHLSNCIRRL------ PHUM009020 --VDPTSTSKLLQHLGTCIRKL------ XP972493 --VDAVAGRKLLQHLGACVRQL------ AglaA007570 --IDPVAGRKLLQHLGACVRQL------ AplaA001225 --VDPAAGRKLLQHLGSCMRQL------ OtauA001741 --IDPASGRKLMQHLGTCVRQL------ XP001949114 PPVDPSAGVKLLHHLGACMRKI------ KDR23063 --IDATTRTQLLQHLGSCVRHI------ NCBI228834 -GVDVTLGTRLMTHLGHALNGL------ HLHmbeta -GVSVDLGTQLMSHLGHRLNYL------ Ccaphlhmbeta -GVNVDLGTQLMSQLGHRLNYL------ Lcuphlhmbeta -GVSVDLGTQLMSHLGHRLNYL------ JGIV11299514 -GLDVTVGQRLLSHLGRCVHQL------ HLHmgamma -GMNVSLGTQLMTHLGQRLNQI------ LcupS1716_1 -GVNVNLGTQLMTHLGQRLNQL------ Ccaphlhmgamma -DVNVNLGTQLMTHLGQRLNQL------ EaffA002154 -GVDITVGSRLMSHLGHKLNTI------ EaffA002152 -GVDITVGSRLMSHLGHKLNTI------ EaffA002149 -GVDITVGSRLMSHLGHKLNTI------ Eaffhlhmbeta -GVDITVGSRLMSHLGHKLNTI------ EaffA002146 -GVDGAMNNRLMNHLGQRL-TS------ Mdes_5782 --VDQKTSSQILKHLNGCISHM------ CLEC002260 AGVGPEEAVRLVRHL----NPV------ EaffA002162 -GLDVRVGQRLIGHLFSPSQSV------ EaffA002166 -GVDVRLSQRLLSHL-SSTAGP------ OFAS009677 GGLDPEAGLRLVSHLSRPRE-------- EaffA002168 SGIDLTLSARLLQHMSICLQSM------ GB43791 -G---EGAERLARHLAAGLQKSRQTN-- Aflo_40 -G---EGAERLARHLAAGLQKSRQTN-- Mrot882617 -G---EGAERLARHLAAGLQKSRQTN-- AECH21585 -G---EAAERLARHLAAGLQ-TGQTN-- ACEP15314 -G---EAAERLARHLAAGLQ-------- OabiM003770 -G---EAAGRLARHLALDLK-STRRV-- ArosM004121 -G---EAADRLARHLASGLH-------- HvitM000199 -GLDARVGRRLVAHLGQCLASP------ KDR23064 -GLDARVGRRLVAHLGQCV-SA------ FoccM004635 -GLDAAVGRRLVAHLGQVVNQV------ XP001949200 -GLDSVVGRRLVEYLAKSV-SR------ EdanM013391 -GLDPRISRRLVAHLGQCADSL------ HLHm3 TQQTDEIGRKIMKFLSTRLIELQTQL-- Ccaphlhm3 QCQADELGGKIMKFLSTRLIEMQHQLLR Lcuphlhm3 QYIDDEVKGKLMKFLSSRLMDMQHNVLI Msex2.02576 -DLDANVSQNLINHLSRLITAQ------ Hmel1 -DLDSNVSQNLIGHLSRMIT-------- EHJ69428.1 -DLDSKVSQNLVGHLSRLITSQ------ HLHm7 -RVDVAFGTTLMTHLGMRLNQL------ Lcuphlhm7 -KVDVQFGTKLMTHLGLRLSQL------ Ccap_espl2 -NVDIQLGTHLMTQLGLRLNQL------ NCBI234834 -GLEPGLGQRLLAHLARCSQQI------ EaffA002158 LGVDRKAVDHVLSQMSNSVN-------- Smar_01651 -GLDESIRNRLIAHLTGR---------- Smar_10005 -GLDETIRNRLIAHLTGQKA-------- Smar_00480 -GLDTGVRARLLIHLSKRV--------- Smar_01368 -GLDTGVRARLLTHLSKRVG-------- HLHmdelta -GLDLKFGTHLMKQLGHQLKDM------ Ccaphlhmdelta -GLDVKFGTKLMKHLGYQLKDL------ LcupS1716_2 -GLNVDFGTRLMKHLGYQLKDL------ Smar_01652 -GLDNGLRARLLTHLTTCVHQV------ Ptep-hes1 -GVDPGLRQRLVSHLSNCLTTM------ LHES005588 -GVDPALRQRLIAHLSNCLTTM------ h -GIEPAQRRRLLQHLSNCINGV------ HLHm5 -AMSVDVGKTVMTHLGVEFQRM------ Ccaphlhm5 -GMSVQVGKSVMTHLGSEFNRL------ Espl -GMSVDLGKSVMTHLGRVYKNL------ LcupA008816 -GMNVQLGKSVMIHLGGEYNRL------ LcupA008817 -GMNVQLGKSVMIHLGGEYNRL------ Lcuphlhm5 -GMSVNMGKAVMTHLGSEFNRL------ Lcupe_spl_ -GMTVEMGKSVMTHLGRSYNRL------ Ccap_espl1 -GMNIELGKAVMTHLGRSYNRL------ ISCW013710 DPVSVR--DRVLAHLQARAREI------ Her ------------QHNGYQ---------- ; end; 2) Hymenopteran bHLH-Orange domain genes #NEXUS BEGIN DATA; dimensions ntax=40 nchar=1085; format missing=? interleave datatype=PROTEIN gap= -; matrix GLEAN_03772 -------------------------------------------------- XP_001601677 -------------------------------------------------- TPRE002242-PA -------------------------------------------------- CFLO017133-PA -------------------------------------------------- GB47783-PA -------------------------------------------------- OABI003747-PA -------------------------------------------------- deadpan -------------------------------------------------- GLEAN_03816 -------------------------------------------------- CFLO010597-PA LIREGPSTSSSRVG------------------------------------ GB47799-PA -------------------------------------------------- OABI003744-PA RPSVEHSVGPSTSADREASRARTVEVRRVHREVGPLETLCSSLASRASTA TPRE002237-PA -------------------------------------------------- h -------------------------------------------------- GLEAN_00039 MTARVHSARHHQ-QTHQQQQNS---------------------------- XP_001601600 MEERSSQIINFP-KLNSNNYNSWKLDMKVALIDRGSWEFITNEVEEPAEG TPRE007753-PA LVARRRRKLDRAVKMTARIHNS---------------------------- GB40519-PA MTARLHSLRHQEKKSAGNTH------------------------------ OABI004222-PA MTARLHSLRHQEKKSAGNSH------------------------------ Side MTAKRDKDYSKNKSAPG--------------------------------- CFLO012108-PA -------------------------------------------------- GB43778-PA MQMHEQ-------------------------------------------- OABI003766-PA MQMHEQ-------------------------------------------- GB43788-PA MAPHTS-------------------------------------------- mbeta MVLEME-------------------------------------------- mdelta MAVQGQ-------------------------------------------- GB43791-PA MMSYEF-------------------------------------------- OABI003770-PA MCA----------------------------------------------- m8 M------------------------------------------------- XP_001603396 MWRVVVARPEENG---TLLSSELPP-------------------PPAPPS GLEAN_11694 MWRVVVARPEENG---TLLSSELPP-------------------PPAPPS TPRE012082-PA MWRVVVARPEESSSGATLLSSEFPAGSASVGSVHHPVNQQQQQHPHAPSN GB51105-PA MWRVVVARSDENS---TLLSSEIGSG------------------PVGPNH OABI005943-PA MWRVVVARSDENS---TLLSSDITSGAMGPMAPMGPMASMAPMGPMGPSH CFLO001794-PA MTSGHQQQHHHHHHPQQQQQQQ--------------------------QQ Hey M--------DHN------------------------------MHVNAPSL GB52039-PA M------------------------------------------------- OABI000326-PA M------------------------------------------------- CFLO008183-PA M------------------------------------------------- TPRE010166-PA L------------------------------------------------- cwo M------------------------------------------------- GLEAN_03772 -----------------------------------------------M-- XP_001601677 -----------------------------------------------M-- TPRE002242-PA -----------------------------------------------MVD CFLO017133-PA -----------------------------------------------M-- GB47783-PA -----------------------------------------------M-- OABI003747-PA -----------------------------------------------MVD deadpan -----------------------------------------------MD- GLEAN_03816 ----------------------------------------------MVTG CFLO010597-PA -----------------------------------------HLVPTMVTG GB47799-PA ----------------------------------------------MVTG OABI003744-PA TRLLTPVFGIKCAPRLPGLTVKCESRDELVCSERVIDAEGENTCTNMVTG TPRE002237-PA ----------------------------------------------MVTG h ----------------------------------------------MVTG GLEAN_00039 ---------QQEVKQATTAAASGAAAGGSS--SSTATGS----------- XP_001601600 TPRIQKVDFQRRKERAFTTIYLGIERQFQTLIANTLDGKEAWQILKDNFE TPRE007753-PA ---------KSHQQQPDSSCNNSNSSNSSSKKVQLSNG------------ GB40519-PA ---------RHYHHHHQQSQHQQSVHQGPS-------------------- OABI004222-PA ---------RHHHHHPQH--HQQVGHQGPS-------------------- Side ---------------------IGFTAAGST-------------------- CFLO012108-PA -------------------------------------------------- GB43778-PA -------------------------------------------------- OABI003766-PA -------------------------------------------------- GB43788-PA -------------------------------------------------- mbeta -------------------------------------------------- mdelta -------------------------------------------------- GB43791-PA -------------------------------------------------- OABI003770-PA -------------------------------------------------- m8 -------------------------------------------------- XP_001603396 QH--PHHPHHH---HWGQ-QHYLPV------------------------- GLEAN_11694 QH--PHHPHHH---HWGQ-QHYLPV------------------------- TPRE012082-PA IQ--PHHQQHHQQHHWAA-HHHYPP------------------------- GB51105-PA IPSLSGPPSGHHHHHWG----YPPP------------------------- OABI005943-PA LSSLPAP--GVASHHWG----YPPP------------------------- CFLO001794-PA QQQQLGPPLHNHHHHWAAHQHYLPP------------------------- Hey -------------HHWG----YAAG------------------------- GB52039-PA -------------------------------------------------- OABI000326-PA -------------------------------------------------- CFLO008183-PA -------------------------------------------------- TPRE010166-PA -------------------------------------------------- cwo -------------------------------------------------- GLEAN_03772 ------SGSDEEFE--------------PQMQSGMT-------------- XP_001601677 ------SGSDEEFE--------------PQMQSGMT-------------- TPRE002242-PA YYSCKMSGSDEEFE--------------PQMQTGMT-------------- CFLO017133-PA ------SGSDDEFE--------------PQIQTGMS-------------- GB47783-PA ------SGSEEELE--------------SHAQPGMT-------------- OABI003747-PA YYDRNMSGSDDEFQ--------------PHVQPGMT-------------- deadpan --YKNDINSDDDFDCSNGYSDSYGSNGRMSNPNGLS-------------- GLEAN_03816 VNASMPTGGVTVGATPP-AQHVPQEAVQP--PTAQTTTT----------- CFLO010597-PA VNASMPTGGVTVGATPP-AQSVPQEAVQP--PVPQTTVTVTANATTVAAT GB47799-PA VGATMPTGGVTVGATPP-AQHVPQEAGQP--PAQTT-TT----------- OABI003744-PA VGATMPTGGVTVGSAPS-VQHGPQEAGQP--PTSTTGAT----------- TPRE002237-PA VQ-TMPAGAVTVSVASP-SQHVPQEAVQPASPPQTTSPT----------- h VTAANMTNVLGTAVVPAQLKETPLKS------------------------ GLEAN_00039 --SSAATAAAV--------------------------------------- XP_001601600 LQSRARLAGLVDEFYDMRFNSDEETIGIYCKKVSEKKLQIKDAGFEIPDI TPRE007753-PA --NSASVAAAV--------------------------------------- GB40519-PA -------------------------------------------------- OABI004222-PA -------------------------------------------------- Side -------------------------------------------------- CFLO012108-PA -------------------------------------------------- GB43778-PA -------------------------------------------------- OABI003766-PA -------------------------------------------------- GB43788-PA -------------------------------------------------- mbeta -------------------------------------------------- mdelta -------------------------------------------------- GB43791-PA -------------------------------------------------- OABI003770-PA -------------------------------------------------- m8 -------------------------------------------------- XP_001603396 ---------------PVPV-----------------QPPP---PPPPPPP GLEAN_11694 ---------------PVPV-----------------QPPP---PPPPPPP TPRE012082-PA ---------------PPP-------------------PPP---PPPPPLP GB51105-PA ---------------PHPSYQP-QHSDVSRHHH---DPRP---PHDLRHP OABI005943-PA ---------------PHPTYQAHQHAEM-RHHHPQTQPQPHSHPHDPRHP CFLO001794-PA ---------------P---------------------PPPPLHPLALPPA Hey ---------------PGVVMPGA----------TATTPQSHWVPPPQSH- GB52039-PA -------------------------------------------------- OABI000326-PA -------------------------------------------------- CFLO008183-PA -------------------------------------------------- TPRE010166-PA -------------------------------------------------- cwo -------------------------------------------------- GLEAN_03772 -------------------------------------------------- XP_001601677 -------------------------------------------------- TPRE002242-PA -------------------------------------------------- CFLO017133-PA -------------------------------------------------- GB47783-PA -------------------------------------------------- OABI003747-PA -------------------------------------------------- deadpan -------------------------------------------------- GLEAN_03816 ----TAT------------------------------------------- CFLO010597-PA APVTTTT------------------------------------------- GB47799-PA ------T------------------------------------------- OABI003744-PA ------V------------------------------------------- TPRE002237-PA -------------------------------------------------- h -------------------------------------------------- GLEAN_00039 -----------------VAAVARLHQHQLQ------QLFVEES------- XP_001601600 LMCFQLIRKLPAEYDNLVQSLYRLDDNKFKFVDLEKQLITEEGRIKQKKK TPRE007753-PA ---------------------VRLQQQQ--------HLYLDE-------- GB40519-PA -------------------------------------------------- OABI004222-PA -------------------------------------------------- Side -------------------------------------------------- CFLO012108-PA -------------------------------------------------- GB43778-PA -------------------------------------------------- OABI003766-PA -------------------------------------------------- GB43788-PA -------------------------------------------------- mbeta -------------------------------------------------- mdelta -------------------------------------------------- GB43791-PA -------------------------------------------------- OABI003770-PA -------------------------------------------------- m8 -------------------------------------------------- XP_001603396 MQSYASV-----------------------------------HEQSAGN- GLEAN_11694 MQSYASV-----------------------------------HEQSAGN- TPRE012082-PA PSSLAHL-----------------------------------HQRSPPT- GB51105-PA ATATADLRPQ-----------------------------EIRHEMHRPDL OABI005943-PA ATSGTNVPPNVPPGGQGVGDVKADHRHEMRQHQPDMQRPEIRHEMQRTEI CFLO001794-PA VVSSSSSSPVASSSSSSTSSSAGAAGAPSSHGYP--------HEQQ---- Hey ------------------------------------------HSAHSNH- GB52039-PA -------------------------------------------------- OABI000326-PA -------------------------------------------------- CFLO008183-PA -------------------------------------------------- TPRE010166-PA -------------------------------------------------- cwo -------------------------------------------------- GLEAN_03772 -------------------------------------------------- XP_001601677 -------------------------------------------------- TPRE002242-PA -------------------------------------------------- CFLO017133-PA -------------------------------------------------- GB47783-PA -------------------------------------------------- OABI003747-PA -------------------------------------------------- deadpan -------------------------------------------------- GLEAN_03816 -------------------------------------------------- CFLO010597-PA -------------------------------------------------- GB47799-PA -------------------------------------------------- OABI003744-PA -------------------------------------------------- TPRE002237-PA -------------------------------------------------- h -------------------------------------------------- GLEAN_00039 --------------------------------------STSPNPQSLYDA XP_001601600 DDGLDSSKDNKVNVICRYCKKPGHIKKDCYTLKRKNEYSTRENSQSNTKA TPRE007753-PA ---------------------------------------TSSSPCT---- GB40519-PA -------------------------------------PAASPSP------ OABI004222-PA -------------------------------------PAPSPTP------ Side -------------------------------------------------- CFLO012108-PA -------------------------------------------------- GB43778-PA -------------------------------------------------- OABI003766-PA -------------------------------------------------- GB43788-PA -------------------------------------------------- mbeta -------------------------------------------------- mdelta -------------------------------------------------- GB43791-PA -------------------------------------------------- OABI003770-PA -------------------------------------------------- m8 -------------------------------------------------- XP_001603396 -------------------------------------------------- GLEAN_11694 -------------------------------------------------- TPRE012082-PA -------------------------------------------------- GB51105-PA RHQPSELHRPEMA---RH---HQDL--MRPDMATEIRSSHEFPDLKIDVA OABI005943-PA RH---EMQRPEIRHEIRHEIRHQDMPGMRSEL-TELRASHELPELKIDIT CFLO001794-PA -------------------------------------------------- Hey -------------------------------------------------- GB52039-PA -------------------------------------------------- OABI000326-PA ----------------------------------------TLIVEAQVKS CFLO008183-PA -------------------------------------------------- TPRE010166-PA ----------------------------------------PV-------- cwo ----------------------------------------EPYWNETNGH GLEAN_03772 -------------------------------------------------- XP_001601677 -------------------------------------------------- TPRE002242-PA -------------------------------------------------- CFLO017133-PA -------------------------------------------------- GB47783-PA -------------------------------------------------- OABI003747-PA -------------------------------------------------- deadpan -------------------------------------------------- GLEAN_03816 -------------------------------------------------- CFLO010597-PA -------------------------------------------------- GB47799-PA -------------------------------------------------- OABI003744-PA -------------------------------------------------- TPRE002237-PA -------------------------------------------------- h -------------------------------------------------- GLEAN_00039 ---ESRS----------QTRRRTQSEF----------SYISLE------Y XP_001601600 FYIENESDFFEYDNHEAQVTNATENEFDEWLIDSASTSHFCKEKEWFKNF TPRE007753-PA -------------------------------------------------- GB40519-PA -------------------------------------------------- OABI004222-PA -------------------------------------------------- Side -------------------------------------------------- CFLO012108-PA -------------------------------------------------- GB43778-PA -------------------------------------------------- OABI003766-PA -------------------------------------------------- GB43788-PA -------------------------------------------------- mbeta -------------------------------------------------- mdelta -------------------------------------------------- GB43791-PA -------------------------------------------------- OABI003770-PA -------------------------------------------------- m8 -------------------------------------------------- XP_001603396 ------TGDGHSQDGQQQQ---------HMSRS----LKRPLSDSDCDDV GLEAN_11694 ------TGDGHSQDGQQQQ---------HMSRS----LKRPLSDSDCDDV TPRE012082-PA ------SYPAHLEPSTAEQPIVAQTAGSHEARQSHHHLKRALSDSDCDDV GB51105-PA DIRNQESGQQQQQQQQQQQQQASQQGQAHQQRS----LKRTMSDSDCDDV OABI005943-PA ELRTQESQQPQQQQQQQQQQQS------HQQRP----LKRAMSDSDCDDV CFLO001794-PA --------EHQQQQSNVVTQDTSPSQQHHHQRSS---VKRPMSDSDCDDV Hey -------SHGHSQ------------GHSHGIGS----LKRTLSESDCDDL GB52039-PA ------------------------------------VTHSMDNILNMQYY OABI000326-PA ARADLPFSGILAFGESFREETFESDGALSSVYSDTMVTHSMDNILSMQYY CFLO008183-PA ------------------------------------VTHSMENILNMQYY TPRE010166-PA --------------QRGKDSNSKIIKTTNKKLKIMVTTQTMENILSMQQY cwo AAHPVKYESEAAVSS---------------------FPYCTESSLNFSTS GLEAN_03772 ----------------------KAELRRSNKPIMEKR--------RRARI XP_001601677 ----------------------KAELRRSNKPIMEKR--------RRARI TPRE002242-PA ----------------------KAELRRSNKPIMEKR--------RRARI CFLO017133-PA ----------------------KAELRRSNKPIMEKK--------RRQRI GB47783-PA ----------------------KAELRRSNKPIMEKR--------RRARI OABI003747-PA ----------------------KAELRRSNKPIMEKR--------RRARI deadpan ----------------------KAELRKTNKPIMEKR--------RRARI GLEAN_03816 --TTTPA-----------APRRSSENRRSNKPIMEKR--------RRARI CFLO010597-PA --TTTPAGSPVPAQATAPAPRRSSENRRSNKPIMEKK--------RRQRI GB47799-PA --TTT---------------RRSGENRRSNKPIMEKR--------RRARI OABI003744-PA --ATT---------------RRSGENRR---------------------- TPRE002237-PA -------------------PRRSSENRRSNKPIMEKR--------RRARI h -------------------------DRRSNKPIMEKR--------RRARI GLEAN_00039 SPSPPALSLV----ARHRSYQKLAPAHEANKPLMEKR--------RRARI XP_001601600 KELPPTDILIGDKNAKSQVIGKGDVVFYANKPLMEKR--------RRARI TPRE007753-PA SPSPSP---------------KLVEGRRANKPLMEKR--------RRARI GB40519-PA SLSPSP---------------KHSDGRRANKPLMEKR--------RRARI OABI004222-PA SPSPSP---------------KHSDGRRANKPLMEKR--------RRARI Side --NGSGIKSIGLVSSTQNVTSSQDISKRTNKPLMEKR--------RRARI CFLO012108-PA ---------------------------------MEKR--------RRLRI GB43778-PA -------IMMVDGQE--QPISRTYQYRKVMKPMLERK--------RRARI OABI003766-PA -------IL-ADGQE--QPISRTYQYRKVMKPMLERK--------RRARI GB43788-PA -------YTPVGGMEYEEPVSRTYQYRKVMKPMLERK--------RRARI mbeta -------------------MSKTYQYRKVMKPMLERK--------RRARI mdelta -------RF----------MTKTQHYRKVTKPLLERK--------RRARM GB43791-PA ---------------PHP-VSKTYRYKKITKPLLERK--------RRARI OABI003770-PA ----------------HPGLDGPSLFIQITKPLLERK--------RRARI m8 -----------------EYTTKTQIYQKVKKPLLERQ--------RRARI XP_001603396 FSEESGKEPCN--SPGGDS--CQHTSRKRRRGMIEKK--------RRDRI GLEAN_11694 FSEESGKEPCN--SPGGDS--CQHTSRKRRRGMIEKK--------RRDRI TPRE012082-PA FSEESGKEPCN--SPGGDSSGCHHTSRKRRRGMIEKK--------RRDRI GB51105-PA FSEESGKEPCN--SPGGDS--CQHASRKRRRGMIEKK--------RRDRI OABI005943-PA FSEESGKEPCN--SPGGDS--CQHASRKRRRGMIEKK--------RRDRI CFLO001794-PA FSEESGKEPCN--SPGGDSWPA-HVAQEAQRHDREKTPGSDQRVARRAAT Hey YSEESSKEQISPSEPGS----CQLMSRKKRRGVIEKK--------RRDRI GB52039-PA -PTNSQVDAVPQSSPLRKRRCLNKEQDPMSHRIIEKR--------RRDRM OABI000326-PA APPKTEEGAL--HSPSRKKRCFNKEQDPMSHRIIEKR--------RRDRM CFLO008183-PA SPV--ADDAV-HSPPSRKRRCLSDKQDPMSHRIIEKR--------RRDRM TPRE010166-PA YSQSPEEPV--NSSPRRKRN-VTKEQDPMSHRIIEKR--------RRDRM cwo ATAYSEDDAEYATGRRNK----TSRQDPLSHRIIEKR--------RRDRM GLEAN_03772 NQCLDELKSLILEAMKKDPTR-------HSKLEKADILEMTVKHLQQIQR XP_001601677 NQCLDELKSLILEAMKKDPTR-------HSKLEKADILEMTVKHLQQIQR TPRE002242-PA NQCLDELKSLILEAMKKDPTR-------HSKLEKADILEMTVKHLQQIQR CFLO017133-PA NNCLDELKSLILEAMKKDPTR-------HSKLEKADILEMTVKHLQQIQR GB47783-PA NQCLDELKSLILEAMKKDPAR-------HSKLEKADILEMTVKHLQAVQR OABI003747-PA NQCLDELKSLILEAMKKDPSR-------HSKLEKADILEMTVKHLQTVQR deadpan NHCLNELKSLILEAMKKDPAR-------HTKLEKADILEMTVKHLQSVQR GLEAN_03816 NNCLNDLKALILDAMKKDPAR-------HSKLEKADILEMTVKHLETLQR CFLO010597-PA NNCLNDLKALLLDAMKKDPAR-------HSKLEKADILEMTVKHFETLQR GB47799-PA NNCLNDLKTLILDAMKKDPAR-------HSKLEKADILEMTVKHLETLQR OABI003744-PA ------------------PAR-------HSKLEKADILEMTVKHLETLQR TPRE002237-PA NNCLNELKSLILDAMKKDPAR-------HSKLEKADILEMTVKHLESLQR h NNCLNELKTLILDATKKDPAR-------HSKLEKADILEKTVKHLQELQR GLEAN_00039 NQSLAALKALILDSARLENTK-------HSKLEKADILELTVRHL---QR XP_001601600 NQSLAALKALILDSARLENTK-------HSKLEKADILELTVRHL---QR TPRE007753-PA NQSLAALKALILDSARLENTK-------HSKLEKADILELTVRHL---QR GB40519-PA NQSLAALKALILDSARLENTK-------HSKLEKADILELTVRHL---QR OABI004222-PA NQSLAALKALILDSARLENTK-------HSKLEKADILELTVRHL---QR Side NQSLAILKALILESTKTQNAKNGEGQAKHTKLEKADILELTVRHF---QR CFLO012108-PA NQSLAALKALILDSARLENTK-------HSKLEKADILELTVRHL---QR GB43778-PA NRCLDELKDLMVTALAGDGENV-------AKLEKADILELTVRHLHKLQR OABI003766-PA NRCLDELKDLMVTALAGDGENV-------AKLEKADILELTVRHLHKLQR GB43788-PA NRCLDELKDLMVTALQAEGENV-------AKLEKADILELTVRHLHTLRA mbeta NKCLDELKDIMVECLTQEGEHI-------TRLEKADILELTVEHMKKLRA mdelta NLYLDELKDLIVDTMDAQGEQV-------SKLEKADILELTVNYL-KAQQ GB43791-PA NKCLDELKNLMIDALETEGEDI-------SKLEKADILELTVRHLQRLQG OABI003770-PA NRCLEELKDLMVDALETEGENI-------SKLEKADVLELTVRHLQRLQA m8 NKCLDTLKTLVADVRGDDGI---------LRMDKAEMLESAVVFM----R XP_001603396 NASLGELRRLVPAA--ARDP--HS-----GKLEKAEILQLTVEHLRTLRN GLEAN_11694 NASLGELRRLVPAA--ARDP--HS-----GKLEKAEILQLTVEHLRTLRN TPRE012082-PA NASLGELRRLVPAA--ARDP--HS-----GKLEKAEILQLTVEHLRTLRS GB51105-PA NASLGELRRLVPAA--ARDP--HS-----GKLEKAEILQLTVEHLRTLRN OABI005943-PA NASLGELRRLVPAA--ARDP--HS-----GKLEKAEILQLTVEHLRTLRN CFLO001794-PA ARARGGARSPQRKARKSRDPTTHR-----RTPQDAEKQSGGKKEKKKKRK Hey NSSLTELKRLVPSAYEKQG----S-----AKLEKAEILQLTVEHLKSLQS GB52039-PA NNCLADLSRLIPAEYLKKGR---------GRVEKTEIIEMAIRHMKHLQG OABI000326-PA NNCLADLSRLIPAEYLKKGR---------GRVEKTEIIEMAIH------- CFLO008183-PA NNCLADLSRLIPAEYLKKGR---------GRVEKTEIIEMAIRHMKYLQN TPRE010166-PA NNCLADLSRLIPQEYLKKGR---------GRIEKTEIIEMSIRYMKYLTG cwo NSCLADLSRLIPPQYQRKGR---------GRIEKTEIIEMAIRHLKHLQ- GLEAN_03772 QQL----------NNAV-------------A---------TDPAVITKFR XP_001601677 QQL----------NNAV-------------A---------TDPAVITKFR TPRE002242-PA QQL----------TTAV-------------A---------SDPAVLTKFR CFLO017133-PA QQL----------SSAV-------------A---------TDPVVLTKFR GB47783-PA QQL----------STAV-------------A---------TDPAVLTKFR OABI003747-PA QQL----------TAAV-------------A---------TDPAVLTKFR deadpan QQL----------NMAI-------------Q---------SDPSVVQKFK GLEAN_03816 QQV----------ALAS-------------A---------TDPNVLNKFR CFLO010597-PA QQT----------ALAS-------------A---------TDPNVLNKFR GB47799-PA QQV----------ALAA-------------A---------TDPNVLNKFR OABI003744-PA QQV----------ALAA-------------A---------TDPNVLNKFR TPRE002237-PA QQS----------ALTQ-------------V---------ADPTVVNKFR h QQA----------AMQQ-------------A---------ADPKIVNKFK GLEAN_00039 QR--------------S-------------L---------AQPG-LSRYK XP_001601600 QR--------------S-------------L---------AQPG-LSRYK TPRE007753-PA QR--------------S-------------L---------AQPG-LSRYK GB40519-PA QR--------------S-------------L---------AQPG-LSRYK OABI004222-PA QR--------------S-------------L---------AQPG-LSRYK Side HR--------------N-------------L---------DDPT-VNKYR CFLO012108-PA QR--------------S-------------L---------ATPG-LSRYK GB43778-PA QQRL-----------SA-------------N---------PVID-ADRFR OABI003766-PA QQRL-----------SA-------------N---------PVID-ADRFR GB43788-PA ARRL-----------TL-------------T---------PENSYADRFR mbeta QKQLRLSSVTGGVSPSA-------------D---------PKLSIAESFR mdelta QQRVANPQ-------SP-------------P---------PDQVNLDKFR GB43791-PA SRS---STGHLLDTATK-------------S---------GEVSGENRWL OABI003770-PA SRP---SG---LSAQAS-------------P---------GDESAESRWQ m8 QQKTGKSTEIP----AA-------------A---------TPPMPLESFR XP_001603396 KVLRDLG-------------------------------YDSTKLAMDYHA GLEAN_11694 KGAE--G-------------------------------YDSTKLAMDYHA TPRE012082-PA KGGD--G-------------------------------YDSTKLAMDYHA GB51105-PA KGPE--G-------------------------------YDSTKLAMDYHA OABI005943-PA KGPE--G-------------------------------YDSTKLAMDYHA CFLO001794-PA KGPREAGGGEEKERAIG-------------MISVRVEGYDSSKLAMDYHA Hey KTLDSLS-------------------------------YDPQRVAMDYHI GB52039-PA LRQESKH--PAVTSVHSMHPEDSVDS-VSH--------STVASTAAEHYR OABI000326-PA ----TKH--PAVNSMHA-HTEDSVDS-VSH--------SATTSTAAEHYR CFLO008183-PA LRQDSKHHTPVTSVHHNHHAEDSVDSSVSHPSPPSSSSSSSSVSAAEYYK TPRE010166-PA VINDLKRQT-GISAVASHHNDDSVDSSPPR-SPPVVPAVISGNLAQEQYR cwo ---------------------------------------SECQQKESDYR GLEAN_03772 SGFSECASE-----------VSRYV---------NHLENVDPTVKQRLVS XP_001601677 SGFSECASE-----------VSRYV---------NHLENVDPTVKQRLVS TPRE002242-PA SGFSECANE-----------VNRYV---------NHLENVDPTVKQRLVS CFLO017133-PA SGFSECANE-----------VSRYV---------NHLENVDPTVKQRLVS GB47783-PA SGFSECATE-----------VSRYV---------SHLENVDPVVKQRLVS OABI003747-PA TGFSECATE-----------VSRYV---------SHLENVDPAVKQRLVS deadpan TGFVECAEE-----------VNRYV---------SQMDGIDTGVRQRLSA GLEAN_03816 AGFTECANE-----------VGRF-------------PGLEASMKRRLLA CFLO010597-PA AGFSECASE-----------VGRF-------------PGLDAAAKRRLLA GB47799-PA AGFTECAGE-----------VGRF-------------PGLDASVKRRLMA OABI003744-PA AGFTECAGE-----------VGRF-------------PGLDASVKRRLMA TPRE002237-PA AGYNECVSE-----------IGRF-------------PGLDSAAKRRLMA h AGFADCVNE-----------VSRF-------------PGIEPAQRRRLLQ GLEAN_00039 AGYQDCSRE-----------VSRYLDAPDIITGNTTPL--EPAFKQRLLR XP_001601600 AGYQDCSRE-----------VSRYLDAPDIITGNTTPL--EPAFKQRLLR TPRE007753-PA AGYQDCSRELSNNLNTILRHVSRYLDAPDIITGNTTPL--DPAFKQRFIR GB40519-PA AGYQDCSRE-----------VSRYLDAPDIITGNTTPM--DPAVKQRLLR OABI004222-PA AGYQDCSRE-------------------------------------RLLR Side AGYTDCARE-----------VARYLATPEPPPMGTMPTLAEPGSKARLLR CFLO012108-PA AGYQDCSRE-------------------------KQPRWSDTGEK----K GB43778-PA AGYTHCANE-----------VSRCLAATP---------GVDVALGTKLMT OABI003766-PA AGYTHCANE-----------VSRCLAATP---------GVDVALGTKLMT GB43788-PA EGFTQCAQE-----------VSSFLS-TPVA------AAVHPAAGAQLMR mbeta AGYVHAANE-----------VSKTLAAVP---------GVSVDLGTQLMS mdelta AGYTQAAYE-----------VSHIFSTVP---------GLDLKFGTHLMK GB43791-PA SGFGHCAAE-----------AYRFLSAVPGE------GA------ERLAR OABI003770-PA SGFGHCAAE-----------ACRFLSALPGE------AA------GRLAR m8 NGYMNAVNE-----------VSRVMASTP---------GMSVDLGKSVMS XP_001603396 VGWGECVAE-----------VGRYLVTMEGLDERD-------PLRLRLLS GLEAN_11694 VGWGECVAE-----------VGRYLVTMEGLDERD-------PLRLRLLS TPRE012082-PA VGWGECVAE-----------VGRYLVTMEGLDERD-------PLRLRLLS GB51105-PA -------------------------------------------------- OABI005943-PA VGWGECAAE-----------VGRYLVTMEGLDERD-------PLRLRLLS CFLO001794-PA VGWGECAAE-----------VGRYLVTMEGFDERN-------PLRLRLLS Hey IGFRECAAE-----------VARYLVTIEGMDIQD-------PLRLRLMS GB52039-PA LGFQECLSETMHFLVEVEGFFAR------------------DSLCVQLIN OABI000326-PA LGFQECLSETMHFLVEVEGFFAR------------------DSLCVQLIS CFLO008183-PA LGYQDCLGEAMHFLVEVEGFFAR------------------DNLVVQLIE TPRE010166-PA HGYQDCLQEVVHYLDE-EAHMPR------------------ETVFSQLVQ cwo SGYMDCMKEAAKFLYDVH----M------------------QDFCHRLLG GLEAN_03772 HLNNCVTNLQQ---VSPFYNHY---------------------------- XP_001601677 HLNNCVTNLQQ---VSPFYNHY---------------------------- TPRE002242-PA HLNNCMTNLQQ---VSPYYNHY---------------------------- CFLO017133-PA HLNNCVSNLQQ--PLSPFYNHY---------------------------- GB47783-PA HLNNCVSNLQQ---MAPFYSHY---------------------------- OABI003747-PA HLNNCVSNLQQ---MAPFYGHY---------------------------- deadpan HLNQCANSLEQIGSMSNFSNGYRGGLFP---------------------- GLEAN_03816 HLSTCLSNAD-SNSANQ-TTASQSVQSA---------------------- CFLO010597-PA HLASCMAAAD-SNAGVQ-TSVQQAAQNA---------------------- GB47799-PA HLASCLGPVEASNNNGQ-TA-NQQPVQP---------------------- OABI003744-PA HLASCLGPVE-TNSAGQ-PGPGQQPVQP---------------------- TPRE002237-PA HLSNVVVSSDA--NGNQ-TVPTQQSIQT---------------------- h HLSNCINGVKTELHQQQ-RQQQQQSIHA---------------------- GLEAN_00039 HLDSCVSELDLDLGSRPDSGLGSSPGSVT--DRVLGPASPGPLDP---HQ XP_001601600 HLDSCVSELDLDLGSRPDSGLGSSPGSVT--DRVLGPASPGPLDP---HQ TPRE007753-PA HLDSCVSELDLDLGSRPDSGLGSSPGSVT--DRVLGPGSPLPLDPAAHHQ GB40519-PA HLDSCVSELDLDLGSRPDSGLGSSPGSVT--DRVTGSGSPGPLE---HH- OABI004222-PA HLDSCVSELDLDLGSRPDSGLGSSPGSVT--DRVPGAASPGAMD---HH- Side HLDQCIAEIDVEICPHSTAAFAESPSSSSCFDLNHGKKSQ-PEEHSLDY- CFLO012108-PA HL-------------------GSS-------------------------- GB43778-PA HLGHKLNSMDKT-------------------------------------- OABI003766-PA HLGHKLNSMDKT-------------------------------------- GB43788-PA HLGGCLRRLEGT-------------------------------------- mbeta HLGHRLNYLQVV-------------------------------------- mdelta QLGHQLKDMKQE-------------------------------------- GB43791-PA HLAAGLQKSRQTNSTLK--------------------------------- OABI003770-PA HLALDLKSTRRV-------------------------------------- m8 HLGRVYKNLQQFHE------------------------------------ XP_001603396 HLQSFHR--E------------QP---AQS-------------------- GLEAN_11694 HLQSFHR--E------------QP---AQS-------------------- TPRE012082-PA HLQSFHR--E------------QPQPNGQT-------------------- GB51105-PA ---SFHR--E------------HHHPPPAA-------------------- OABI005943-PA HLQSFHR--E------------HP-PPPGG-------------------- CFLO001794-PA HLQSFQRAAE------------QQQPPP---------------------- Hey HLQYFVQQRELSAKSCASPGGWSPAAPSSSGYQP---------------- GB52039-PA HLQQHCEKILAT---------------SDRLGFPH----PE--------- OABI000326-PA HLQQHCEKIIAT---------------SDRLGFPH----PE--------- CFLO008183-PA HLKKHCNKVLAT---------------NDRLGFPH----P---------- TPRE010166-PA HLQQHYDKTLSM---------------RDIHGYHQ----AA--------- cwo RLQEHIDEMFKTDCYKSTRSCHMPDNVSASSGSPHQAYHPP--------- GLEAN_03772 ------------VPYMPERLYPEIKVGFQSDVQ----------------- XP_001601677 ------------VPYMPERLYPEIKVGFQSDVQ----------------- TPRE002242-PA ------------VPFMQDRIYSDVKVGFPSDGQ----------------- CFLO017133-PA ------------VPYMPERLYPEVKVGFQADVQ----------------- GB47783-PA ------------VPYMPERLYPEVKVGFQSDFQ----------------- OABI003747-PA ------------VPYIPERLFPEVKVGFQSEYQ----------------- deadpan ---------ATAVTAAPTPLFPSLPQ------------------------ GLEAN_03816 ---------QTTTTQLQVHILP--QVDAST-IQ----------------- CFLO010597-PA ---------ATTTTQLQVHILP--QVDASG-IQ----------------- GB47799-PA ---------APPTTQLQVHILP--QVDATPRIQ----------------- OABI003744-PA ---------APPTTQLQVHILP--QVDSTPRIQ----------------- TPRE002237-PA ---------AG--AHLQVHILPSSQGDNPAQVQ----------------- h ---------QMLPSPPSSPEQDSQQGAAAPYLF----------------- GLEAN_00039 QAVATAAAAAAAA-HCSAALG---AALIKQEMPELVEAA----------- XP_001601600 QAVATAAAAAAAA-HCSAALG---AALIKQEMPELVEAA----------- TPRE007753-PA QAVAAAAAAAAAAAHCNAAVALGSAALIKQELPELDAAAAAAVGVSGLAA GB40519-PA ---------VPSTAHCSTSLN--PVGLIKAEIPDIEPA------------ OABI004222-PA ---------APPTPHCSTAL-------IKSEMPELDAT------------ Side --------SSQDSNPVDYSKGLKMVAAEQRTLP----------------- CFLO012108-PA -------------------------------------------------- GB43778-PA -------------------------------------------------- OABI003766-PA -------------------------------------------------- GB43788-PA -------------------------------------------------- mbeta -------------------------------------------------- mdelta -------------------------------------------------- GB43791-PA -------------------------------------------------- OABI003770-PA -------------------------------------------------- m8 -------------------------------------------------- XP_001603396 -------------------------------------------------- GLEAN_11694 -------------------------------------------------- TPRE012082-PA -------------------------------------------------- GB51105-PA -------------------------------------------------- OABI005943-PA -------------------------------------------------- CFLO001794-PA -------------------------------------------------- Hey -------------------------------------------------- GB52039-PA -----------------------------------MPTTNGVANGNSG-- OABI000326-PA -----------------------------------MPTSNGLTG--SS-- CFLO008183-PA -----------------------------------MDLASGTGTGCSSEI TPRE010166-PA -----------------------------------EPTLLHSFSGIASQF cwo -----------------------------------LCHLRDMLATSASDV GLEAN_03772 --------S---GDENNNGS------------------------------ XP_001601677 --------S---GDENNNGS------------------------------ TPRE002242-PA --------S---GDENNNGS------------------------------ CFLO017133-PA --------GCGGGDENNNSSHGA--------------------------- GB47783-PA --------N---GDENNNGS------------------------------ OABI003747-PA --------S---GDENNNGS------------------------------ deadpan -------------DLNNNSRTES--------------------------- GLEAN_03816 --------VQ---Q--SNGIVYM--------------------------- CFLO010597-PA --------VQ---Q--SNGIVYM--------------------------- GB47799-PA --------VQ---Q--SNGIFFT--------------------------- OABI003744-PA --------VQ---Q--SNGIFFT--------------------------- TPRE002237-PA --------VQ---TQPANSILYM--------------------------- h --------GI---QQTASGYFLP--------------------------- GLEAN_00039 --RADSSTAP--GDENNNSS--------RPTSAFAPM---------QPGA XP_001601600 --RADSSTAP--GDENNNSS--------RPTSAFAPM---------QPGA TPRE007753-PA SARPDNGAAPIPGDENNNSS--------RPTSAFAQM---------HAAA GB40519-PA --RPDSSTTA--GDENNNNSNSSSNGNSRPTSAFGQVNTTNLDSHHHHPP OABI004222-PA --RPDSSTTA--GDENNNSS--------RPTSAFGTGPHVPPGLDHHHA- Side -------VTPAPQDENNNRGLQAQAQTPIPIQVQSQTQ----GQTSPHVD CFLO012108-PA -------------------------------------------------- GB43778-PA -------------------------------------------------- OABI003766-PA -------------------------------------------------- GB43788-PA -------------------------------------------------- mbeta -------------------------------------------------- mdelta -------------------------------------------------- GB43791-PA -------------------------------------------------- OABI003770-PA -------------------------------------------------- m8 -------------------------------------------------- XP_001603396 -------------------------------------------------- GLEAN_11694 -------------------------------------------------- TPRE012082-PA -------------------------------------------------- GB51105-PA -------------------------------------------------- OABI005943-PA -------------------------------------------------- CFLO001794-PA -------------------------------------------------- Hey -------------------------------------------------- GB52039-PA -YPHTS--IPTICQPNG--------------------------------- OABI000326-PA -FAHAA--IPTICPSNS--------------------------------- CFLO008183-PA TFNHTNGNVPLMCPSNNGLDLLSA-------------------------- TPRE010166-PA GQSRLQDTVQMSNYLNNANNNNNS-------------------------- cwo EHSQDHNDVKDLSFRNHLNQLQRSQQAAAAAAVAAAAVAVANGSSPASNA GLEAN_03772 -----------------------ARIQIPSNCHL--------------PP XP_001601677 -----------------------ARIQIPSNCHL--------------PP TPRE002242-PA -----------------------SRIQIPNNVQLIPSRLPNGELALLVPP CFLO017133-PA -------------------TAPGPRIQIPSNVQLIPSRLPTGELALLVPP GB47783-PA -----------------------ARIQIPNGVQLIPSRLPTGELALLVPQ OABI003747-PA -----------------------ARIQIPSGVHLIPSRLPTGELALLVPQ deadpan -------------------SA--PAIQM-GGLQLIPSRLPSGEFALIMPN GLEAN_03816 -------------------NANGTALQ------LVPTRLPNGNIALVA-A CFLO010597-PA -------------------NANGTALQ------LVPTRLSNGNIALVA-A GB47799-PA -------------------NANGMGLQ------LVPTRLENGDIALVLPA OABI003744-PA -------------------NANGTGFQ------LVPTRLPNGDIALVLPA TPRE002237-PA -------------------TPNGASLQ------LVPTRLSNGSIALVAGS h -------------------N----GMQ------VIPTKLPNGSIALVLPQ GLEAN_00039 VPVVPGMEQP---------GSSQPNSMLSV-VQVIPSRLPDGQVVFLLPS XP_001601600 VPVVPGMEQP---------GSSQPNSMLSV-VQVIPSRLPDGQVVFLLPS TPRE007753-PA GVLPPGVPPPVIDPQAAASGNQPPSNMLSV-VQVIPSRLPDGQVVFLLPS GB40519-PA PPPPPGISVI---DQA--SSSQQNPNMLSV-VQVIPSRLPDGQVVFLLPS OABI004222-PA -----GVAAAVAADQA--STSQQNPGMLSV-VQVIPSRLPDGQVVFLLPS Side AVAPSELSYEEDRNKVCANVLEQYKQQLKAHVQQQPE---SANGVLVLPP CFLO012108-PA -------------------------GELCVSLRVC--------------- GB43778-PA -----------------------------------------GPLTIHVAA OABI003766-PA -----------------------------------------GPLTIHVAS GB43788-PA -----------------------------------SSAANLGTTTSNNNT mbeta -----------------------------------VPSLPIG-VPLQAPV mdelta -----------------------------------EEIIDMAEEPVNLAD GB43791-PA ---------------------------------TNVLTQTLASLDLTADL OABI003770-PA -----------------------------------MPKPTLTSSEVLMDS m8 -----------------------------------AQTMSESEAATELSI XP_001603396 -------------------------------------------------- GLEAN_11694 -------------------------------------------------- TPRE012082-PA -------------------------------------------------- GB51105-PA -------------------------------------------------- OABI005943-PA -------------------------------------------------- CFLO001794-PA -------------------------------------------------- Hey -----------------------------------NCAAAPYQSYAAPAN GB52039-PA --------HS-----------------------------------DHGSS OABI000326-PA --------HS-----------------------------------DRGSS CFLO008183-PA ---TATNAHNTII----NTTTNNIGSHILNLQHPHPLRTGSSTSPDQCSS TPRE010166-PA ---SSINNNNSNAANNNNSQPQNLSQNGSSNNNNNSSIHQNHNSSDRCSS cwo GVDSKVPLTNGGGTGGAPPAADNVPSNSTGSGSAAACAGGNSNSSGSNSS GLEAN_03772 --GITANFP-FFPPTSE-------SGTRLGQPSAFTAVQRTYSPLLSPST XP_001601677 --GITANFP-FFPPTSE-------SGTRLGQPSAFTAVQRTYSPLLSPST TPRE002242-PA SSGIAANFP-FFPPAAD-------ANTRLGQPSAFTAVQRTHSPLLSPST CFLO017133-PA SANITGNFPGFFPPTGSEQQSTPTGNTRIGTPSAFTAVQRTHSPLLSPST GB47783-PA SATISANFP-FFPPAPE-------SISKISRSSAFTSIHRPQSPLLSPST OABI003747-PA SAGIAANFP-FFPPANE-------ASSRVGQSSAFTAVTRSHSPLVSPST deadpan TGSAA-------PPPGPFAWPGSAAGVAAGTASAALA------SIANPT- GLEAN_03816 G---------------------------------AKSTTSVVSPVSSPSS CFLO010597-PA G---------------------------------AKAPSSILSPVSSPSS GB47799-PA G---------------------------------AKAT-----PVASPAT OABI003744-PA G---------------------------------AKAT-----PMTSPSS TPRE002237-PA P---------------------------------KSSPIAPPSTIPTPAS h S-----------------------LPQQQQQQLLQHQQQQQQLAVAAAAA GLEAN_00039 HY--------------------------VQLAAAAAANGISIGP--NPPT XP_001601600 HY--------------------------VQLAAAAAANGISIGP--NPPT TPRE007753-PA HY--------------------------VQLAAAAAANGINIGP--NPPT GB40519-PA HY--------------------------VQLAAAAAANGISIGP--NPPT OABI004222-PA HY--------------------------VQLAAAAAANGISIGP--NPPT Side HY--------------------------VQLAAAL---GLSAQPLVDP-- CFLO012108-PA ---------------------------------------LSVG------- GB43778-PA -PQSSPSS-------------------------SSELSSDEYSMPLTPAS OABI003766-PA SPQASPTSG------------------------ASDVGSEDYSMPLTPAS GB43788-PA TTTTAAAST------------------------TTVASSTSVSKT-TPAV mbeta EDQAMVTPP------------------------PSECDSLE-SGACSPAP mdelta QKRSK-----------------------------------------SPRE GB43791-PA LASS---IP------------------------IDKSASPNQNAITY-RG OABI003770-PA TVSSSLNLP------------------------IEASRSPDFGRISSPMG m8 NCNSAPLSP---------------------------ASSGYHSDCESPAP XP_001603396 ----------------------------------------------TP-- GLEAN_11694 ----------------------------------------------TP-- TPRE012082-PA ----------------------------------------------TPHQ GB51105-PA ----------------------------------------PVPPPVTSLS OABI005943-PA ----------------------------------------PVPS--APLT CFLO001794-PA -----------------------------------------------PPT Hey PGAYVSSYPTLSASPSQQAQQLGGRTSVSRTSGSAVTESLPSHDLHSDSS GB52039-PA SGVSSFGDPE---R---PLRPTIAIPPPA---IVSDDSNHST-------- OABI000326-PA SGVSSFGDPE---R---P-RPII--PPPT---VVSDDSNHSN-------- CFLO008183-PA SGVSSYDSSE---S---KSSQRALVPPPV---LTSDDSNHSN-------- TPRE010166-PA SGVSSYDSSE---PLTIVARPGGAFQPPH-----SDDSNHSSGSTSGVSH cwo NAASSTICPPAGGSCPAKVTPLAAHQQPHQAPVITSTAPHHHHHHTDSSH GLEAN_03772 ST-SSFEEN--HHSE-QYPTSLSP---PQHFKMPEQSPASSSNKS----F XP_001601677 ST-SSFEEN--HHSE-QYPTSLSP---PQHFKMPEQSPASSSNKS----F TPRE002242-PA ST-SSFEEN--HHSESQYPTSLSP---QMRFKVPEKSPASSSSKS----L CFLO017133-PA STTSSFEESLMAHGSESYPTC---------FKVPEQSPASSSSSSSSSSY GB47783-PA STSSYGEES---HQSEHYPQANSPNHQERQFKVPGQSPASSKSFS----- OABI003747-PA STSSIGEDGP--HSPGH-----------RRFKAPDGSSGNN--------F deadpan -----------HLNDYTQSFRMSAFSKPVNTSVPANLPEN-------LIH GLEAN_03816 SPAPSSP-------------------LPTLIPIPQRTASTASASSSTSST CFLO010597-PA SPVPSSP-------------------LPTLIPIPQRTASTASASSSSSST GB47799-PA SPAPTSP-------------------MPALIPIPQRTASTASASSSSSSA OABI003744-PA SPAPTSP-------------------LPTLIPIPQRPASTASASSSSSSA TPRE002237-PA SPAPSSP-------------------LPTLIPIPDRTASTASASSSVSSN h AAAAAQQ-------------------QPMLVSMPQRTASTGSASSHSSAG GLEAN_00039 AIWAATNMSLLKATDKLI-KRPLCDEPQQDWP-DAAALSA---------- XP_001601600 AIWAATNMSLLKATDKLI-KRPLCDEPQQDWP-DAAALSA---------- TPRE007753-PA AIWAATNMSLLKQTDKLL-KRPLCDEA--DWPLDPISSMT---------- GB40519-PA AIWAATNMSLLKATDKLAAKRPHEDI--QEWQ-DAATVAVNAAAAAVAAT OABI004222-PA AIWAATNMSLLKATDKLV-KRPLDDP--ADWP-DAP-------------- Side ---IATRTDFERLIELQRVQPHLAGKLSPSFPGGLEAAHVAAAAAAYANS CFLO012108-PA -------------------------------------------------- GB43778-PA SQPSPVRTDI---------------------------------------- OABI003766-PA SQPSPVRTDV---------------------------------------- GB43788-PA SPTANVMINV---------------------------------------- mbeta SEAS---------------------------------------------- mdelta ED------------------------------------------------ GB43791-PA RIPDAVTFNI--PSGC----NSGTNVENGEKLERGCVSEMSRDSKE---- OABI003770-PA --PSNLLEDVEKPSSLLLPRSKGPGEEETSEGDDCSLADDAVDLGD---- m8 SPMPEEGEK----------------------------------------- XP_001603396 QQQASPQ------------------------------------------- GLEAN_11694 QQQASPQ------------------------------------------- TPRE012082-PA QQQQQQQ------------------------------------------- GB51105-PA STSTSTN------------------------------------------- OABI005943-PA STSSGPS------------------------------------------- CFLO001794-PA QSQQHPH------------------------------------------- Hey SQQQQQQ------------------------------------------- GB52039-PA HS---------HSTPPTTTCKP---------------------------- OABI000326-PA HS---------HSTPPTSS-RP---------------------------- CFLO008183-PA HS---------HASGSYSVTMPVHHHHSDVENGLLHHHQQQQ-------- TPRE010166-PA HH---------HHHHHNMSPPPAHHNYNGSVNHNNNNNNNNHHECPRAAA cwo HDFESSREPILHTDTSNMHSPPPRDLLLQQHPHLAHSHHTQDSLMSVRMR GLEAN_03772 SSPETQ-KPQISSS---------------------SD------------- XP_001601677 SSPETQ-KPQISSS---------------------SD------------- TPRE002242-PA SSPETQ-KPQISSS---------------------SD------------- CFLO017133-PA SSPETQ-KPQISSS---------------------SD------------- GB47783-PA SSPETQ-KPQISST---------------------SD------------- OABI003747-PA SSPEMQLAKQLPQS---------------------PA------------- deadpan TLPGQTQLPVKNST---------------------SP------------- GLEAN_03816 SSTSTSAASPVAFE---------------------AP------------- CFLO010597-PA SSTSTSAASPVAFE---------------------AP------------- GB47799-PA SSTSTSAASPVAFE---------------------AP------------- OABI003744-PA SSTSTSAASPVAFE---------------------AP------------- TPRE002237-PA MSTSTSAASPVAFD---------------------SQ------------- h YESAPGSSSSCSY----------------------AP------------- GLEAN_00039 ---------------------------------GLKP------------- XP_001601600 ---------------------------------GLKP------------- TPRE007753-PA ---------------------------------NGKP------------- GB40519-PA VAAAATSGNASVSASISASAPVSTFATNAISAIGTKP------------- OABI004222-PA -----------------------------------KP------------- Side MAVAASAGAS-------------------VAAMATSG------------- CFLO012108-PA -------------------------------------------------- GB43778-PA -------------------------------------------------- OABI003766-PA -------------------------------------------------- GB43788-PA -------------------------------------------------- mbeta -------------------------------------------------- mdelta -------------------------------------------------- GB43791-PA -------------------------------------------------- OABI003770-PA -------------------------------------------------- m8 -------------------------------------------------- XP_001603396 -------------------------------------------------- GLEAN_11694 -------------------------------------------------- TPRE012082-PA -------------------------------------------------- GB51105-PA -------------------------------------------------- OABI005943-PA -------------------------------------------------- CFLO001794-PA -------------------------------------------------- Hey -------------------------------------------------- GB52039-PA ----S--------NYKFKSSIKQRFSAE-R--IKSS-------------- OABI000326-PA ----P--------NYKFKSSIKQRFSAE-R--IKSS-------------- CFLO008183-PA ---SS--------TYKFKNSIKQRFSADQR--IKSS-------------- TPRE010166-PA AAAAS--------SYKLKNSIMQRFTADQSSVIKTS-------------- cwo NYSESSHEIEHNNNYKYKNHIKERFVHELHDEETSSEHCPVAAHLQSDHS GLEAN_03772 -------------------------------------------------R XP_001601677 -------------------------------------------------R TPRE002242-PA -------------------------------------------------R CFLO017133-PA -------------------------------------------------R GB47783-PA -------------------------------------------------S OABI003747-PA -------------------------------------------------P deadpan -------------------------------------------------P GLEAN_03816 -------------------------------------------------P CFLO010597-PA -------------------------------------------------P GB47799-PA -------------------------------------------------P OABI003744-PA -------------------------------------------------P TPRE002237-PA -------------------------------------------------S h -------------------------------------------------P GLEAN_00039 -------------------------------------------------P XP_001601600 -------------------------------------------------P TPRE007753-PA -------------------------------------------------S GB40519-PA -------------------------------------------------S OABI004222-PA -------------------------------------------------G Side -------------------------------------------------A CFLO012108-PA -------------------------------------------------- GB43778-PA -------------------------------------------------- OABI003766-PA -------------------------------------------------- GB43788-PA -------------------------------------------------- mbeta -------------------------------------------------- mdelta -------------------------------------------------- GB43791-PA -------------------------------------------------- OABI003770-PA -------------------------------------------------- m8 -------------------------------------------------- XP_001603396 -------------------------------------------------- GLEAN_11694 -------------------------------------------------- TPRE012082-PA -------------------------------------------------- GB51105-PA -------------------------------------------------- OABI005943-PA -------------------------------------------------- CFLO001794-PA -------------------------------------------------- Hey -------------------------------------------------- GB52039-PA -------------------------------------------------- OABI000326-PA -------------------------------------------------- CFLO008183-PA -------------------------------------------------- TPRE010166-PA -------------------------------------------------- cwo HLQALSEHSKDGTEPEIAPIMAKKRKLAEAAANGEIPLEVHTESSNAGAS GLEAN_03772 NSPMLFPEQKVEIVNSTSVIKRDADSLDAFNGNANMHSLRQPLSVITDK- XP_001601677 NSPMLFPEQKVEIVNSTSVIKRDADSLDAFNGNANMHSLRQPLSVITDK- TPRE002242-PA ISPVI-EQSKVE------PSKREADIVES-GFNTVPQSYRQPLSVITDK- CFLO017133-PA SSP---PQLLVP------VEQQQPQRSEANSPPTTGLVKREPLSVITDK- GB47783-PA KSPV---STFLETKSDIGYRKEIADSSESLNSNG-MQNLRQPLSVITDKT OABI003747-PA PAPMEPKLRGLDCVPAVADVAPVGDAVAASPTQATLHSLRQPLTVITDKS deadpan LSPISSISSHCE------ESRAASPTVDVMSKHSFAGVFSTPPPTSAETS GLEAN_03816 SN--FREQSQSP----IAYTN--VSHRDVATSPATTTGYTSDP-EFDPRV CFLO010597-PA SN--YREQSQSP----ISYT------RDAATSPAS--GYTSDP-EFDPRV GB47799-PA AT--FRDQ---P----TAYTNGGNSHRDVATSPA--NGYTSDP-EFDPRV OABI003744-PA AA--FREQ---T----SGYQSG-TSHRDVATSPAAANGYTSDP-EFDPRV TPRE002237-PA SSSYHCEESRSP----AP-------SHDASTSPSSA-GYHSDP-EYDQRI h -------------------------------SPANS---SYEPMDIKPSV GLEAN_00039 KSPRVEAPPTEQPLDFTTS-----SAKKLXXXXXXXXXXXXXXXXXXWRV XP_001601600 KSPRVEAPPTEQPLDFTTS-----SAKKLXXXXXXXXXXXXXXXXXXWRV TPRE007753-PA KIPKSEG---EQPLDFTTS-----SVKKLKAAAARLVAQQQAETSCADKQ GB40519-PA KSPRLEQP--EQPLDFTTT-----S-KKPKPSTKSSVTAVSSNVDHHFQQ OABI004222-PA KSPRLDHP--EQPLDFTTT-----S-KKLKSARMAAAAAAA-------QA Side GTPTVHQ---ERPASVAASVSSGVSMSELKSMPATQQSSPRSESGIGSNE CFLO012108-PA --------------------------KKRKSV------------------ GB43778-PA -----------------------------EGISQSHQGLLQVA------- OABI003766-PA -----------------------------E--AASHQGLLQVA------- GB43788-PA ----------------------------LQNVYTPPQSPVSVASSSGESV mbeta -------------------------------------------------- mdelta -------------------------------------------------I GB43791-PA --------------------------GQTEEKVKTEIKVEDEEEIDVERV OABI003770-PA --------------------------KVKEDATSSQVIMEEEEEIDVERV m8 -------------------------------------------------- XP_001603396 -----HH-----------------------------LHH--PPLA----- GLEAN_11694 -----HQQQQQQQQQQQQQHQQSSYNNEQPSSS--SLHH--PPLA----- TPRE012082-PA -----QQQQQQQQQQQQQQHQQQQQQQQQHQSSYEQQHHQHPSAA----- GB51105-PA -----YE-------------------------TASTVSAGMPPGT----- OABI005943-PA -----YE-------------------------PPSSASSGMPPGA----- CFLO001794-PA -----APHHIHGQ------------------------HHQSPYPP----- Hey -----QQQQQQQQQHQQQQHQQQQQRTQTTPQPTQQQHYTHDHSAVHSEQ GB52039-PA -------PPPT----TSTEK------------P----------------- OABI000326-PA -------PPPT----S--EK------------P----------------- CFLO008183-PA -----CSPPPRHDSPTRSGQ------------P----------------- TPRE010166-PA -----PSPPPTPQFATCNQSSNGIVEPESKHHP----------------- cwo SANRLDKPSPSFNFSDIKDIKAELHNGNSNSSPLLAKLSAVAAAGGQLST GLEAN_03772 YNRPL--TIPKREG-----GLKR---Y-NSDGL-LAISD-KRPR---YHE XP_001601677 YNRPL--TIPKREG-----GLKR---Y-NSDGL-LAISD-KRPR---YHE TPRE002242-PA YNRTL--ELPKT-------GLKR---H-HSDGL-LTVAE-KRPR---YHE CFLO017133-PA CNRTLGGLLPSTRREQHYHSLKR---HASSEGLVLQLGEQKKPRREVVHE GB47783-PA YNCT--GSLPPRK-----EAIKR---H-NSDGL-LAISD-KKAR---YQE OABI003747-PA QNRST--IVPAKK-----EGLKR---H-RSDGL-LTISE-KRLR----FE deadpan FNTS--GSLNLSAGSHDSSGCSRPLAHLQQQQVSSTSGIAKRDR-----E GLEAN_03816 YS-PPL-QKP----------------------ISLVM------RKSVIKE CFLO010597-PA YS-PPL-QKP----------------------LSLVM------RKSVIKE GB47799-PA YSSPPL-QKP----------------------LALVM------RKSVVRE OABI003744-PA YS-PPL-QKP----------------------LALVM------RKSVLPE TPRE002237-PA FS-PPL-QKP----------------------LSLVM------RKSVIKE h IQRVPMEQQP----------------------LSLVI------KKQ-IKE GLEAN_00039 ------------------VERNRDRERE---------------------- XP_001601600 ------------------VERNRDRERE---------------------- TPRE007753-PA RSPTAGVSSQSSAAGEVKAEAMSDAYHH---------------------- GB40519-PA QQQQQQQQQQQQQQQQHQHQHHQQQQQQQQQQQFVGRLTTEGSVPQHSEG OABI004222-PA AASAADHRAASLHPALHPALHPALHP-----------------VALHDE- Side NEAPATSPRPQTSNAARQALRQRQEEEY---------------------- CFLO012108-PA -------------------------------------------------- GB43778-PA KPNEP--------------------------------------------- OABI003766-PA KSAEP--------------------------------------------- GB43788-PA ESSNA--------------------------------------------- mbeta STSGP--------------------------------------------- mdelta HHGEE--------------------------------------------- GB43791-PA DDVDP--------------------------------------------- OABI003770-PA DETDP--------------------------------------------- m8 -------------------------------------------------- XP_001603396 -------------------------------------------------- GLEAN_11694 -------------------------------------------------- TPRE012082-PA -------------------------------------------------- GB51105-PA -------------------------------------------------- OABI005943-PA -------------------------------------------------- CFLO001794-PA -------------------------------------------------- Hey QVPT---------------------------------------------- GB52039-PA --SSSH-----G---VPIFALHDAGSYYVPLTVEASLLRPHLN---FMW- OABI000326-PA -----H-----G---VPIFALHDGGAFYVPLTVESSLLRPHLT---FIP- CFLO008183-PA --HVSQQQQQQG---VPVFALHDNGGFYVPLTLEASLLRPHLG---VGS- TPRE010166-PA --HQHHQHKQQPPLLVPAFALHNAG-YYVPLTLDTDCVREKMA---LQEI cwo PSSTTAPLPPRHTFTVPIFALHGQGNYYVPLNVDYNALVPFLNGMDLLEK GLEAN_03772 A--STSVAS--TSN---CHSPS--LKIKEE----CADDAEKTNSVI--SS XP_001601677 A--STSVAS--TSN---CHSPS--LKIKEE----CADDAEKTNSVI--SS TPRE002242-PA A--TTSAASMGSPS---SHSPS--LKIKEE----CSQEVERITPVV--SS CFLO017133-PA ACTTTTIGGASTSSSFTCHSPTGVIRVKEEFPNSSSDEQVRPASLVGSSS GB47783-PA AISST----MNSSNGHLKSEGDQPISVEDLSGRPTCSANRNSNPNPIKFA OABI003747-PA AVTSTTT--------LMPPSRSSLANVSQHRDQDSGKVVGSASSSSTSSA deadpan AEAESS---------------------------DCSLDEPSSKKFLAGAI GLEAN_03816 SMEQKY-------------------------------------------- CFLO010597-PA SIDEKC-------------------------------------------- GB47799-PA -VEEKP-------------------------------------------- OABI003744-PA -VEDKP-------------------------------------------- TPRE002237-PA AIEEKC-------------------------------------------- h --EEQP-------------------------------------------- GLEAN_00039 RQ-TRR------------------------------------------TL XP_001601600 RQ-TRR------------------------------------------TL TPRE007753-PA QPGSHR------------------------------------------TI GB40519-PA RPSSHT------------------------------------------SS OABI004222-PA RPSSHA------------------------------------------GS Side ----HY------------------------------------------MA CFLO012108-PA -------------------------------------------------- GB43778-PA -------------------------------------------------- OABI003766-PA -------------------------------------------------- GB43788-PA -------------------------------------------------- mbeta -------------------------------------------------- mdelta -------------------------------------------------- GB43791-PA -------------------------------------------------- OABI003770-PA -------------------------------------------------- m8 -------------------------------------------------- XP_001603396 ----------------------------WPP---AQYPGPGPGQYPGV-- GLEAN_11694 ----------------------------WPP---AQYPGPGPGQYPGV-- TPRE012082-PA ---------------TTASSLQLQAAAVWPPPLAAQYSGP-VGQYQSSAA GB51105-PA ---------------GTMPPILGGGALGW-------------GQYPG--- OABI005943-PA ---------------GSVPPLLGGGALGW-------------GQYPG--- CFLO001794-PA ---------------GTEIGPAGPLAAPWPP---AQYS----AQYPA--- Hey ---------YIELTNSNRPAAIGSDSLSY----------SAAPQYP---V GB52039-PA DTGPDTVLHPVTISVNFNHSN----------------------------- OABI000326-PA DTGPDTVLHPVTISVNFNHST----------------------------- CFLO008183-PA DLGPETVLHPITISVNFNNSSQ---------------------------- TPRE010166-PA DTAP--VFHPVNIPVRFPANAA---------------------------- cwo SYTSMPVVHPININVNFMPSSPSASLLAAAAAAAVAVGKQQQQQAVVAAG GLEAN_03772 ETSATP--N------------GDMWRPW------- XP_001601677 ETSATP--N------------GDMWRPW------- TPRE002242-PA ESSQSA--N------------NDMWRPW------- CFLO017133-PA ETSATTTTN------------GDMWRPW------- GB47783-PA AIAGSSGTN------------GDMWRPW------- OABI003747-PA SVSSTTNGNCKGPEFPSSTGVGDMWRPW------- deadpan EKSSSA------------------WRPW------- GLEAN_03816 ------------------------FRPW------- CFLO010597-PA ------------------------WRPW------- GB47799-PA ------------------------WRPW------- OABI003744-PA ------------------------WRPW------- TPRE002237-PA ------------------------WRPW------- h ------------------------WRPW------- GLEAN_00039 QVYRFV------------S--------L------- XP_001601600 QVYRFV------------S--------L------- TPRE007753-PA PYEAHT------------KDEEGMWRPW------- GB40519-PA EFVTGIR-SPSPIPQQPSKDEEGMWRPW------- OABI004222-PA EGTEVVLPATSPGGAQPVKDEEGMWRPW------- Side QAAAAAAAA---------GQDESMWRPW------- CFLO012108-PA ----------------------------------- GB43778-PA -----------------------IWRPW------- OABI003766-PA -----------------------VWRPW------- GB43788-PA -----------------------VWRPW------- mbeta -----------------------MWRPW------- mdelta -----------------------VWRPW------- GB43791-PA -----------------------MWRPW------- OABI003770-PA -----------------------MWRPW------- m8 -----------------------LWRPW------- XP_001603396 --------------QYGQQQHGKPYRPWGGAEVAY GLEAN_11694 --------------QYGQQQHGKPYRPWGGAEVAY TPRE012082-PA AAAAAAAAAAAAASQYSQQQHGKPYRPWG-AELAY GB51105-PA --------------QYPQQQHGKPYRPWG-AELAY OABI005943-PA --------------QYPQQQHGKPYRPWG-AELAY CFLO001794-PA --------------QYGQQQHGKPYRPWG-AELAY Hey SGLPGQDYNNSSVLQYATPNGAKPYRPWG-AEMAY GB52039-PA ------P----------PAWSHHHSPTHQP--QT- OABI000326-PA ------S----------PSWPQL-SPTHQ---QA- CFLO008183-PA ---QQVA----------PSWSAQPSPAHHQ--VQ- TPRE010166-PA ---PLAAVAAVSPPSSVPAAAVWRADTSSP--MVH cwo AGLPLSTNSAAAQAAAVAAAAVAKAKLEQAMNQSW ; end; 3)Basal bHLH-Orange domain genes #NEXUS BEGIN DATA; dimensions ntax=59 nchar=223; format missing=? interleave datatype=PROTEIN gap= -; matrix LHES005588-PA ----RATKPIMEKRRRARINQCLSELKTLILDALN-K-DP-----S---- PTEP023132-PA ----RATKPIMEKRRRARINQCLSELKTLILDALN-K-DP-----S---- CSCU023709-PA ----RATKPIMEKRRRARINQCLSELKTLILDALN-K-DP-----S---- Smar_10930 ----RSNKPVMEKRRRARINQCLNELKALILEALR-K-DP-----S---- GB47783-PA ----RSNKPIMEKRRRARINQCLDELKSLILEAMK-K-DP-----A---- PTEP012764-PA ----RSTKPIMEKRRRARINNSLTELKNLILDALK-K-DN-----A---- CSCU023710-PA ----RSTKPIMEKRRRARINNSLTELKNLILDALK-K-DN-----A---- deadpan ----KTNKPIMEKRRRARINHCLNELKSLILEAMK-K-DP-----A---- h KSDRRSNKPIMEKRRRARINNCLNELKTLILDATK-K-DP-----A---- GB47799-PA ----RSNKPIMEKRRRARINNCLNDLKTLILDAMK-K-DP-----A---- Smar_02338 ----RSNKPLMEKRRRARINHSLTELKTLILNAVK-K-DN-----S---- AGS55439 ----KANKPLMEKRRRARINESLNMLKTLVLDALK-R-DT-----S---- AGS55438 ----RSNKPLMERRRRCRINASLNQLKTLVLDAMN-K-DT-----S---- AGS55440 ----KSTKPIMEKRRRARINASLTELKTLLLDVMK-K-EG-----T---- AGS55435 ----KSTKPIMEKRRRARINASLLELKALLLDVMR-Q-EG-----V---- Smar_10937 ----KSNKPIMEKRRRARINQCLNELKTLILEALR-K-D----------- XP_003741403 ----RTTKPIMEKRRRARINNSLNELKNLILDYNKSK-DT-----A---- AGS55436 ----KVNKPLMEKRRRARINSCLSQLKMLVLQAVK-K-DG-----C---- Smar_01651 ----KIVKPLLERRRRARINQCLMELKNLLRETNPSI-DN-----N---- Smar_10005 ----KIVKPLLERRRRARINQCLMELKNILRETNPSI-DN-----D---- Smar_00480 ----KVIKPLLEKRRRARINNCLTELKDLLVETYKN--DI-----S---- Smar_01368 ----KVIKPLLEKRRRARINNCLTELKDLLVETYKN--DI-----T---- CSCU014162-PA ----RASKPLMEKKRRARINKSLCELKSLILDTVKQETQN-----P---- AGS55441 ----KINKPLMEKKRRERINNCLNQLKMFLMDAT--KKDS-----S---- Side DISKRTNKPLMEKRRRARINQSLAILKALILESTKTQNAKNGEGQA---- GB40519-PA ----RANKPLMEKRRRARINQSLAALKALILDSARLENTK---------- Smar_01652 ----KMVKPILEKRRRARMNKSLDELKAYIVDVRKSE-------IS---- Smar_02091 ----RSSKPLMEKRRRARINHSLAELKNLVVDSTRKEN-------T---- PTEP013288-PA ----KASKPLMEKRRRARINHSLAQLKSLIIDPNTTEK-------S---- CSCU023711-PA ----RISKPLMEKRRRARINHSLSELKSLLLDAIKSES-------P---- AGS55442 ----RINKPLMERRRRARINQSLTQLKTLVLSSMNKD-------PA---- GB43788-PA ----KVMKPMLERKRRARINRCLDELKDLMVTALQAEGENV--------- GB43778-PA ----KVMKPMLERKRRARINRCLDELKDLMVTALAGDGENV--------- mbeta ----KVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHI--------- mdelta ----KVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQV--------- GB43791-PA ----KITKPLLERKRRARINKCLDELKNLMIDALETEGEDI--------- AGS55437 -------KPLMEKRRRARINESLSRLKLMVLGEVKRKN-------T---- ISCW013710 -----VSKPLMEKRRRARINRCLSQLKALLVDSSKPES-------P---- Smar_09777 ----KKRRGLIEKRRRDRINSSLTELRRLVPTAFEKQHNNTDLLLDVRSL Smar_10957 ----KKRRGLIEKRRRDRINSSLTELRRLVPAAFEKQHTNAEYPLDVRSL PTEP006276-PA ----KRRRGIIEKRRRDRINSSLSELRRLVPAAFEKQ------------- CSCU010292-PA ----KRRRGIIEKRRRDRINNSLSELRRLVPAAFEKQ------------- CSCU016495-PA ----KRRRGIIEKRRRDRINNSLSELRRLVPAAFEKQ------------- AGS55448 ----KKRRGVIEKRRRDRINNSLSELRRLVPTAYEKQ------------- Hey ----KKRRGVIEKKRRDRINSSLTELKRLVPSAYEKQ------------- XP_003739265 ----KRKRGAIEKRRRDRINNCLNELRRLVPAAFEKQ------------- GB51105-PA ----KRRRGMIEKKRRDRINASLGELRRLVPAAARDPH------------ AGS55446 ----KFKKHMVEKRRRNRINYALDQLKKIVLNGLQKD------------- AGS55445 ----KFKKHMVEKRRRNRINYALDQLKMMVLEGLDKD------------- AGS55447 ----K--KHMVEKRRRSRINGSLEQLKMLVLTGLNKD------------- AGS55444 ----KLKKVMVEKRRRTRIDRALVQMKNMVLEALHVQ------------- AGS55443 ----HINKPLVEKKRRERINSFLEELKALVLTALNKD------------- m8 ----KVKKPLLERQRRARINKCLDTLKTLVADVRGDD------------- CSCU006002-PA -----MSHRIIEKRRRDRMNNCLADLSRLIPTAYLKK------------- XP_003744690 -----MSHRIIEKRRRDRMNNCLADLSRLIPAIYLKK------------- GB52039-PA -----MSHRIIEKRRRDRMNNCLADLSRLIPAEYLKK------------- PTEP001998-PA ------SHRIIEKRRRDRMNNCLADLSRLVPTNYLKK------------- Smar_05416 -----LSHRIIEKKRRDRMNNCLANLSSLLPSSYWKK------------- cwo -----LSHRIIEKRRRDRMNSCLADLSRLIPPQYQRK------------- LHES005588-PA ----RHSKLEKADILEMTVRHLQNIQRQQM--------A----------- PTEP023132-PA ----RHSKLEKADILEMTVRHLQNIQRQQM--------A----------- CSCU023709-PA ----RHSKLEKADILEMTVRYLQNVQRQQM--------A----------- Smar_10930 ----RHTKLEKADILEMTVKHLQNMQRHQM--------A----------- GB47783-PA ----RHSKLEKADILEMTVKHLQAVQRQQL--------S----------- PTEP012764-PA ----RHSKLEKADILEMTVKHLQNLQMQQM--------N----------- CSCU023710-PA ----RHSKLEKADILEMTVKHLRNLQRHQI--------T----------- deadpan ----RHTKLEKADILEMTVKHLQSVQRQQL--------N----------- h ----RHSKLEKADILEKTVKHLQELQRQQA--------A----------- GB47799-PA ----RHSKLEKADILEMTVKHLETLQRQQV--------A----------- Smar_02338 ----KHSKLEKADILEMTVKYLQNLQRQQL--------T----------- AGS55439 ----RYSKLEKADILEMTVKHLRSVQRQQM--------S----------- AGS55438 ----QYSKLEKADILEMTVRHLRSMQRQQL--------S----------- AGS55440 ----RHHKMEKADILEMTVKHLRQIQRQQF--------T----------- AGS55435 ----RHQKMEKADILEMAVKHLRQIQKG---------------------- Smar_10937 ----------------MTVNYLQNLQRQQM--------A----------- XP_003741403 ----RHNKLEKADILEMAVRHVQMLHRQTS--------V----------- AGS55436 ----SYSKLEKADILEMTVQYLKTVQKNQM--------L----------- Smar_01651 ----EANRLEKADILELTVRQLKGLQLQR--------------------- Smar_10005 ----EANRLEKADILELTVRQLKGLRLQR--------------------- Smar_00480 ----EPSKLEKADILELTVRHLRELRQQR--------------------- Smar_01368 ----EPSKLEKADILELTVRHLRELRQQQ--------------------- CSCU014162-PA ----RHSKLEKADILEMAVRHLQTLQGQ---------------------- AGS55441 ----YYSKLEKADILEMSVKYLKNLQRQHL--------A----------- Side ----KHTKLEKADILELTVRHFQRHRN----------------------- GB40519-PA -----HSKLEKADILELTVRHLQRQRS----------------------- Smar_01652 ----DPSKLEKADILEHTVHHLRDLRRQQQ--------Q----------- Smar_02091 ----RYNKLEKADILEMAVNHLQNLQNQK--------------------- PTEP013288-PA ----RQSKLEKADILELTVRHLHEIKRRQR--------T----------- CSCU023711-PA ----RHSKMEKADLLELTVRHLQELHRRQR--------T----------- AGS55442 ----RYNRLEKADILEMTVNHLKGLQSQQT--------K----------- GB43788-PA ------AKLEKADILELTVRHLHTLRAARRL------------------- GB43778-PA ------AKLEKADILELTVRHLHKLQRQQRL------------------- mbeta ------TRLEKADILELTVEHMKKLRAQKQLRLSSVTGG----------- mdelta ------SKLEKADILELTVNYL-KAQQQQRVANPQ--------------- GB43791-PA ------SKLEKADILELTVRHLQRLQGSRS---STGHLL----------- AGS55437 ----KISKLDKADILEMTVEYVNRIAGN---------------------- ISCW013710 ----RHARLEKADILEMTVNHLQALHRQRRTVPFTMNPAHEYMSLAALTC Smar_09777 LSPQGSSKLEKAEILQMTVDHLKMLHSKGLD------------------- Smar_10957 LSPQGSAKLEKAEILQMTVDHLKMLHTKGLD------------------- PTEP006276-PA ----GSAKLEKAEILQLTVDHLKMLHAKGFD------------------- CSCU010292-PA ----GSAKLEKAEILQMTVDHLKMLHAKGFD------------------- CSCU016495-PA ----GSAKLEKAEILQMTVDHLRTLHSKGFD------------------- AGS55448 ----GSAKLEKAEILQMTVDHLKVLHSKGLN------------------- Hey ----GSAKLEKAEILQLTVEHLKSLQSKTLD------------------- XP_003739265 ----ASAKLEKAEILQMTVEHLRGLEAKGLG------------------- GB51105-PA -----SGKLEKAEILQLTVEHLRTLRNKGPE------------------- AGS55446 --PSQYDKMEKADILDLTVSYLFKVKTNNPITALARRFTSTPVTSYPATP AGS55445 --PTKYDKMEKADILDLTVKYLHRILKENI------HFGPEMMQSLPPMF AGS55447 --PEQYDKIEKADILDLTVTYL-KQLTSSPARGQQAPVQPVQYSARPLTV AGS55444 --PEKYAKMEKADILDLTVRFLRRVRQER----QTAVTGPDPRSMYPAAA AGS55443 --VTDFAKMEKADILEMAVNHIKKTKPQ---------------------- m8 ----GILRMDKAEMLESAVVFMRQQKTGK--------------------- CSCU006002-PA ----GRGRIEKTEIIEMAIKHLKHLQA------HSCKD------------ XP_003744690 ----GRGRVEKTEIIEMAIKHLKHLQS------HACND------------ GB52039-PA ----GRGRVEKTEIIEMAIRHMKHLQGL----RQESKH------------ PTEP001998-PA ----GRGRIEKTEIIEMAIKHLKHLQN------HPCND------------ Smar_05416 ----SRGRIEKTEIIEMAITHMKYLQMQIKLNRHSVSQ------------ cwo ----GRGRIEKTEIIEMAIRHLKHLQSE---------------------- LHES005588-PA -----SAISTDS-------------------SVLN--KFKAGFNEC---- PTEP023132-PA -----TAISTDS-------------------SVLN--KFKAGFNEC---- CSCU023709-PA -----AAISTDP-------------------TVLN--KFRAGFNEC---- Smar_10930 -----VAMASDP-------------------TVLN--KFRSGFTEC---- GB47783-PA -----TAVATDP-------------------AVLT--KFRSGFSEC---- PTEP012764-PA -----P----DP-------------------AMIA--KFRAGFAEC---- CSCU023710-PA -----TAVMADP-------------------NAIG--KYRSGFNEC---- deadpan -----MAIQSDP-------------------SVVQ--KFKTGFVEC---- h -----MQQAADP-------------------KIVN--KFKAGFADC---- GB47799-PA -----LAAATDP-------------------NVLN--KFRAGFTEC---- Smar_02338 -----ASADSDT-------------------SSLTSTKFSAGYGEC---- AGS55439 -----AAMATDS-------------------TVME--KYRNGYQEC---- AGS55438 -----AAATSDT-------------------SVVG--KFQAGFSEC---- AGS55440 -----VALAEDP-------------------TVLD--KYQSGFNEC---- AGS55435 -----VGLSTDR-------------------YVLN--KHNAGFNEC---- Smar_10937 -----LTMATNP-------------------QIMS--KYRAGFGEC---- XP_003741403 -----QRAAVDP-------------------NVSD--KFRAGYMEC---- AGS55436 -----AAATVDP-------------------SVIN--RYSAGYTEC---- Smar_01651 ------RV-----------------------HQVDVAEFRAGFTEC---- Smar_10005 ------SVI----------------------HRVDVAEFRAGFTEC---- Smar_00480 ------RVIVST-------------------RRNDANDFRAGYSEC---- Smar_01368 ------RVIVTT-------------------RRTDANDFRVGYNEC---- CSCU014162-PA ----------DK-------------------KDIYTSKFRAGFEEC---- AGS55441 -----VAMATDP-------------------KVIS--KYATGYSQC---- Side --------LDDP-------------------TV---NKYRAGYTDC---- GB40519-PA --------LAQP-------------------GL---SRYKAGYQDC---- Smar_01652 -----RGMAVTN-------------------GAV-ASRFGAGFTEC---- Smar_02091 -----------S-------------------SVSSINKYLAGFSEC---- PTEP013288-PA -----VSLLEGR-------------------NPRR--KFEIGYTEC---- CSCU023711-PA -----VSLLNDP-------------------YLKN--KFQAGYEEC---- AGS55442 -----YSL-SDP-------------------ETLA--KFQSGFSQC---- GB43788-PA --------TLTP-------------------ENSYADRFREGFTQC---- GB43778-PA --------SANP-------------------VID-ADRFRAGYTHC---- mbeta -----VSPSADP-------------------KLSIAESFRAGYVHA---- mdelta --------SPPP-------------------DQVNLDKFRAGYTQA---- GB43791-PA -----DTATKSG-------------------EVSGENRWLSGFGHC---- AGS55437 ----------GT-------------------QKPQFDKYRAGFNTC---- ISCW013710 NSACPARLLDDS-------------------EVRH--KFRAGYEEC---- Smar_09777 ------ALAYDP-------------------HKFAMDYHSVGFREC---- Smar_10957 ------PLTCDP-------------------HKFAMDYHGLGFQEC---- PTEP006276-PA ------ALSFDP-------------------HKFAMDYHIIGFREC---- CSCU010292-PA ------ALTFDP-------------------HKFAMDYHNIGFREC---- CSCU016495-PA ------IFNSNP-------------------NQFSMDYHNIGFREC---- AGS55448 ------GYNFDP-------------------ATLAMDYRSVGFREC---- Hey ------SLSYDP-------------------QRVAMDYHIIGFREC---- XP_003739265 ------ALANDP-------------------QKFAMEYHRVGFREC---- GB51105-PA ------G--YDS-------------------TKLAMDYHASFHREHHHPP AGS55446 CDYFA-------------------------------PVTSQGREEPP--- AGS55445 SEHFAGGFFHHPQLPPPLG-------------ILPDPCPSSGILEEPLDL AGS55447 NTHNMHQMPSYPVQAP--------------------PMHSQGIP------ AGS55444 AAA-AAMYPGYPPAAPSTSTSAGNPYPFKMAPLRPIPTTLSG---HPYAH AGS55443 -----------------------IEKYGLYGTALAKKRHRQGYIAC---- m8 -STEIPAAATPP---------------------MPLESFRNGYMNA---- CSCU006002-PA --------PNNCEVANAAEQDR-------------KHQYRLGFQEC---- XP_003744690 --------PATCEVAQRIDTDH-------------RHQYRLGFQEC---- GB52039-PA --------PAVTSVHSMHPEDSVDSVSHSTVASTAAEHYRLGFQEC---- PTEP001998-PA --------PNNCEVARTTESDH-------------KRQYKSGYSEC---- Smar_05416 --------LINVTVADTATEDKSDN---------SKDSFCFGYQEC---- cwo --------------CQQKESD-----------------YRSGYMDC---- LHES005588-PA -ATEVTRYV--------SRIEG-V-------------------------- PTEP023132-PA -ATEVTRYV--------NRIEG-V-------------------------- CSCU023709-PA -ATEVSRYV--------SRIEG-V-------------------------- Smar_10930 -ASEVSRYV--------NRIE--V-------------------------- GB47783-PA -ATEVSRYV--------SHLEN-V-------------------------- PTEP012764-PA -ANEVNRFM--------GRIDG-V-------------------------- CSCU023710-PA -ANEVNRYL--------NQVEG-V-------------------------- deadpan -AEEVNRYV--------SQMDG-I-------------------------- h -VNEVSRF------------PG-I-------------------------- GB47799-PA -AGEVGRF------------PG-L-------------------------- Smar_02338 -ANEVTRYL--------EGGEGHV-------------------------- AGS55439 -AGEVSRYL--------TSIDG-L-------------------------- AGS55438 -AGEVSRYL--------STVDG-I-------------------------- AGS55440 -VGEVSRYV--------DSLEG-L-------------------------- AGS55435 -ANEVSRYL--------NDTDN-V-------------------------- Smar_10937 -VAEVSRFL--------SGSPA-V-------------------------- XP_003741403 -AKEVSRYL--------SRSES-V-------------------------- AGS55436 -TNEAIRYL--------SSMEG-V-------------------------- Smar_01651 -ANEVAMCV--------TTLPG-L-------------------------- Smar_10005 -ANEVAVCV--------TTLPG-L-------------------------- Smar_00480 -AGEVAACL--------GNMPG-L-------------------------- Smar_01368 -ASEVAACL--------GNMPG-L-------------------------- CSCU014162-PA -TREVDRYF--------SE-DPKV-------------------------- AGS55441 -ATEVTHYL--------GKLDG-L-------------------------- Side -AREVARYLATPEPPPMGTMPTLA-------------------------- GB40519-PA -SREVSRYLDAPDIITGNTTPM---------------------------- Smar_01652 -ANEVSVYL--------STLPG-L-------------------------- Smar_02091 -LHQVSLCM--------DQLDG-L-------------------------- PTEP013288-PA -AREVDLFLS-------SLVDSTV-------------------------- CSCU023711-PA -AREIERFVG-------RL--DNV-------------------------- AGS55442 -AAEISNYLDQI---------SDL-------------------------- GB43788-PA -AQEVSSFLS---TPVAAAV------------------------------ GB43778-PA -ANEVSRCLAA--TP---GV------------------------------ mbeta -ANEVSKTLAA--VP---GV------------------------------ mdelta -AYEVSHIFST--VP---GL------------------------------ GB43791-PA -AAEAYRFLSA--VPGEGAERLAR-------------------------- AGS55437 -ADEVRSYLAGRK---------EI-------------------------- ISCW013710 -ILETRRFLCSLADRQLLTNSGAD-------------------------- Smar_09777 -AAEVARYLVTMEGMDV--------------------------------- Smar_10957 -ATEVSRYLISMEGMDV--------------------------------- PTEP006276-PA -ASEVARYLVAIEGMDL--------------------------------- CSCU010292-PA -ASEVARYLVAIEGMDL--------------------------------- CSCU016495-PA -VSEIARYLVGMEGMDL--------------------------------- AGS55448 -AAEVARYLVTAEGMDI--------------------------------- Hey -AAEVARYLVTIEGMDI--------------------------------- XP_003739265 -AAEVARYLVAVEGMDL--------------------------------- GB51105-PA PAAPVPPPVTSLSSTSTSTNYETASTVSAGMPPGTGTMPPILGGGALGWG AGS55446 ---------------------RNVTSPLN----CIPFD-E---NNNAVGQ AGS55445 HGRGMASQHSVSASQSSMTSRSNVTSQSRAESPCIDVDSD---SDDSDGE AGS55447 -----------------------------AHQGLLQIACN---NYESSYD AGS55444 IGNLPRGPYRPSASPRFNPLKAAVTAAENAAHVTSQLASNMASNMASQLP AGS55443 -LNDTLRYLA-----------------------------------DSGSA m8 -VNEVSRVMASTPGM----------------------------------- CSCU006002-PA -MSETVRFLVEIEGV---------------------------------YA XP_003744690 -MSECVRFLVDIEGR---------------------------------YA GB52039-PA -LSETMHFLVEVEGF---------------------------------FA PTEP001998-PA -LNEAVKYVSDNEGM---------------------------------FS Smar_05416 -MAEIMHFLVEVEGF---------------------------------YP cwo -MKEAAKFLYDVH------------------------------------- LHES005588-PA DPALRQRLIAHLSNCLTTM---- PTEP023132-PA DPGLRQRLVSHLSNCLTTM---- CSCU023709-PA DPALRQRLLNHLSHCLNGL---- Smar_10930 DSGVKQRLVAHLANCVSHL---- GB47783-PA DPVVKQRLVSHLNNCVSNL---- PTEP012764-PA DHTIRQRLMNHLANCLTGM---- CSCU023710-PA DTAVKQRLLNHLANCLTSL---- deadpan DTGVRQRLSAHLNQCANSLEQ-- h EPAQRRRLLQHLSNCINGV---- GB47799-PA DASVKRRLMAHLASCLGPV---- Smar_02338 DATARTHLINHLSRCMNGL---- AGS55439 EPNVRNRLMNHLMGCVQKV---- AGS55438 SPDIRVRLLDHLGNSVSRV---- AGS55440 TPEIRSRLLAHLTKCVNGV---- AGS55435 DIDTRTKILDHLMNVVQG----- Smar_10937 DTAVQQRLISHLNNNFSGL---- XP_003741403 DGSVRQCLLSHLSQ----TSP-- AGS55436 NKQLKSRLLDHLT-----TGT-- Smar_01651 DESIRNRLIAHLTGR-------- Smar_10005 DETIRNRLIAHLTGQKA------ Smar_00480 DTGVRARLLIHLSKRV------- Smar_01368 DTGVRARLLTHLSKRVG------ CSCU014162-PA DPSLKSRLLTHLGGCLSSL---- AGS55441 DQDVKSRLSSHLNNCVQKL---- Side EPGSKARLLRHLDQCIAEI---- GB40519-PA DPAVKQRLLRHLDSCVSEL---- Smar_01652 DNGLRARLLTHLTTCVHQV---- Smar_02091 NKDDRMHLLHHLTKCLSNI---- PTEP013288-PA NSELHRRLTQHLSRRLHDL---- CSCU023711-PA KYEVKQQLRHHLNCRLDEM---- AGS55442 DSQVKEGILGHV----------- GB43788-PA HPAAGAQLMRHLGGCLR--RL-- GB43778-PA DVALGTKLMTHLGHKLN--SM-- mbeta SVDLGTQLMSHLGHRLNYLQV-- mdelta DLKFGTHLMKQLGHQLKDMKQ-- GB43791-PA HLAAGLQKSRQTNSTLKTNVLTQ AGS55437 DVEVRTRVIDHLANFIQNLQ--- ISCW013710 PVSVRDRVLAHLQARAREI---- Smar_09777 QDPLRLRLMSHLQCY-------- Smar_10957 QDPLRLRLMSHLQCF-------- PTEP006276-PA QDPLRVRLMSHLQCY-------- CSCU010292-PA QDPLRLRLMSHLQCY-------- CSCU016495-PA QDPLRLRLMSHLQCY-------- AGS55448 QDPLRLRLMSHLQCY-------- Hey QDPLRLRLMSHLQYF-------- XP_003739265 QDPLRLRLLSHLQCY-------- GB51105-PA QYPGQYPQQQHGKPYRP------ AGS55446 VNL-NYSNLPPQP---AQPLTPP AGS55445 DDIIRVDSVKSDT---VKGFQPV AGS55447 VTSSRYDVITPQQQCRSRSLSP- AGS55444 SMASHVAGMTSLQAAPHKSAVPT AGS55443 RPEVSHQVAVHLSSAF------- m8 SVDLGKSVMSHLGRVYKNLQQ-- CSCU006002-PA GDGLCVRLVNHLQKHFDKI---- XP_003744690 NDEFCIRLMTHLKKHLDKL---- GB52039-PA RDSLCVQLINHLQQHCEKI---- PTEP001998-PA S-TLVGRMSEHLIKHFEKL---- Smar_05416 RENLCIKLLNHLRKHGEEI---- cwo MQDFCHRLLGRLQEHIDEMFK-- ; end;