The Rockefeller University Press, doi: 10.1083/jcb.201505123
Microtubule plus end–associated CLIP-170 initiates HSV-1 retrograde transport in primary human cells
Podcast
biosights: October 26, 2015
CLIP-170 tips its hand in viral transport
The Rockefeller University Press
biosights{at}rockefeller.edu
After entering a cell, many viruses move toward the nucleus by binding to the microtubule-based motor protein dynein. Jovasevic et al. reveal, however, that herpes simplex virus must first associate with the plus ends of microtubules in a process that requires the dynein accessory factor dynactin and the plus end tracking proteins EB1 and CLIP-170. This biosights episode presents the paper by Jovasevic et al. from the October 26th, 2015, issue of The Journal of Cell Biology and includes an interview with the paper's corresponding author, Derek Walsh (Northwestern University, Chicago, IL). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.
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