CLUSTAL Caspase3_human/12-248 DYPEMGLCIIINNKNFHKSTGMTSRS----------------------------GTDVDA caspase7_human/40-270 NFEKLGKCIIINNKNFDKVTGMGVRN----------------------------GTDKDA Caspase1_Spod/28-272 NHKHRGMAIIFNHEHFD-IHSLKSRT----------------------------GTNVDS Caspase1_human/39-266 KSSRTRLALIICNEEFDSIPR---RT----------------------------GAEVDI Gingipain/139-360 DKWLGQALCIASAEGGPSADNGESDI----------------------------QHENVI Homo_sapiens/1889-2119 -----HLVLVLDKDLQK----LPWES-MPSLQALPVTR-LP-S------------FRFLL Mus_musculus/1885-2117 -----HLVLVLDKDLQK----LPWESTPILQAQP-VTR-LP-S------------FRFLL Caenorhabditis_elegans/902-1153 -----YTYLVICPHLSQ----FCWERLPIFDEYPYVGR-QV-S------------IHSTF Drosophila_melanogaster/360-634 -----PIILVVDERLDH----LHWEQLVTVQEF---SR-VK-S------------LHCLW Drosophila_virilis/366-640 -----PIILVVDERLDH----MHWEQLASMQE---CTR-IK-S------------LHSLW Drosophila_willistoni/360-635 -----PTILIVDERLDH----FHWEQLATTQ--E-FSR-VK-S------------LHLLW Shizosaccharomyces_pombe/1594-1828 -----HTVLVLDKSVHQ----FPWESLPCLNRQS-VSR-VP-S------------LSILR Saccharomyces_cerevisiae/1391-1630 -----HTFLVVSSSCHL----FPWECLSFLKDLS-ITR-VPSYV----------CLNKLL Asp_nidulans/1828-2067 ------TVLVLDKSLHL----FPWESLPCLQGLP-VCR-VP-S------------LECLR Exophalia_dermatidis/1807-2067 -----HVILVLDKELQA----FPWESMPCLRGRP-VSR-MP-S------------LGAIW Encephalitozoon_hellem/566-772 -----DVVLVLDETTTD----FPFESMPIFRDSA-VYR-VP-S------------LEYLE Encephalitozoon_intestinalis/568-774 -----DVILVLDETTTE----FPFESIPAFKGKS-VYR-VP-S------------LEYLE Encephalitozoon_romaleae/568-774 -----DIILVLDETTTE----FPFESMPIFRGKA-VYR-VP-S------------LEYLE Giardia_lamblia/1424-1642 -----TVVLNTDSAFYR----LPFDHSPLFVSETIVSR-IHAGAETKVGPQ--------- Giardia_intestinalis/482-700 -----KVVLNTDSAFYR----FPFDHSPLFAPETMVSR-IHAGAETRIGPQ--------- Trypanosoma_brucei/897-1159 -----PVYLVLDNELHC----LPFEGIDVLRHGS-VSR-VP-T--------VSFVSTFTS Trypanosoma_cruzi/861-1101 -----SLYLVLDNELHA----LPLEGMDVLLTGN-VAR-VPTS------------TFIST Leishmania_major/1018-1279 -----HVYLVLDGELHA----LPWEALGVCQERS-VSR-VP-S------------LEYLK Perkinsus_marinus/104-331 -----PLYLFLAPCLMN----LPIEFMLTGEH-S-IVR-GG-S------------INLLL Cryptosporidium_muris/2563-2821 -----PIILYLDPLFMN----LPLEGLECNIVQPITRGVHP-S------------ISLSN Esp1_Cry_hominis/313-558 -----PAVIFLDKILIS----LPIESICDLKFQPITRGINRRMCKNN--------IDHLF Cryptosporidium_parvum/2197-2442 -----PTIIFLDKILIS----LPIESICDLKFQPITRGINRRMCKNN--------IDNLF Arabidopsis_thaliana/1873-2176 -----PIILVLDPEVQM----LPWENIPILRKQE-VYR-MP-SV-----------GCISA Medicago_truncatula/451-742 -----PVILVLDPEVQM----LAWENLPILRKQE-VYR-MP-SVSS---------ISFVL Ricinus_communis/1862-2153 -----PLILVLDFEVQM----LPWENLPVLRNQE-VYR-MP-S------------VASIC Ostreococcus_tauri/1105-1323 -----SLMILSLH--------PVHEMTTCLVV------------------------SSEQ Chlamydomonas_reinhardtii/2084-2337 ----CPLLLVLSPCLHA----LPWESMPCLRGRS-VSR-VL-S------------LPACC Volvox_carteri/1800-2079 -----PVLLVLSPALHA----LPWESIPCCHGKELYRILSLQVACATASARTEMQHVNIS Phaeodactylum_tricornutum/1780-2039 -----CTFLVLDENLQRF----PFEGLPSFENTP-VSR-LP-C------------ISFLY Spironucleus_salmonicida/827-1043 -----TFILFYDKLNLI----TDITHVQRISIDP-ILNQIP-LE-------NTFSFINTI Blumeria_graminis/650-903 ----QHTILVLDKALHS----FPWESLPCLDGLA-VSRL-PSL--------ASLRERIIC Caspase3_human/12-248 ANLRETFRNLK------------------YEVRNKND--LTREEIVE--LMRDVSK---- caspase7_human/40-270 EALFKCFRSLG------------------FDVIVYND--CSCAKMQD--LLKKASE---- Caspase1_Spod/28-272 DNLSKVLKTLG------------------FKVTVFPN--LKSEEINK--FIQQTAE---- Caspase1_human/39-266 TGMTMLLQNLG------------------YSVDVKKN--LTASDMTTELEAFAHR----- Gingipain/139-360 ANLLTQYG---------------------YTKIIKCYDPGVTPKNIIDAFNGG------- Homo_sapiens/1889-2119 SYSIIKEYGASPVLSQGVDPRS-------TFYVLNPHNNLSSTEEQFRANFSSE-AG--- Mus_musculus/1885-2117 SYTVTKEAGASSVLSQGVDPQN-------TFYVLNPHSNLSSTEERFRASFSSE-TG--- Caenorhabditis_elegans/902-1153 SQLEAMKSQEKQIPLQIDVQNA--------YYILDPDNNLGETQKRMVEYINK--FN--- Drosophila_melanogaster/360-634 RLFQNHKSNIKHGYYTTNIKR--------GMCVINPDADLVNSGRRLRSFFEYWLSQ--- Drosophila_virilis/366-640 RLFKCHKNQIQCGYYTVNIKR--------GITVINPDADLANSGRRLRSFLEYWLTH--- Drosophila_willistoni/360-635 RLYQWHKPNIHHGYYTVNIES--------GISVINPDGDLPNSGRRLRGFFEYWLGH--- Shizosaccharomyces_pombe/1594-1828 DILSQSFVVNGEYVEVRKEA---------GSYILNPSLDLKHTQEMFEHKLVE--GG--- Saccharomyces_cerevisiae/1391-1630 SRFHYQLPLQVTIEDN-------------ISMILNPNGDLSRTESKFKGMFQKIIDAKPS Asp_nidulans/1828-2067 DRVLHLRSGKQSALSIDRRNG---------TYILNPTGDLKTTQETFEKDLSSLKG---- Exophalia_dermatidis/1807-2067 QRLKVIQDQSSQNDGYTIPSTE-------GTYILNPSSDLTSTQEMFGQAFMTQLSQ--- Encephalitozoon_hellem/566-772 ETPRPSASEKS------------------FFYLLDPENNLPRTQERMSEFLKSSGITN-- Encephalitozoon_intestinalis/568-774 DVPGLEIDRKS------------------FFYLLDPENNLFKTRERISGFLRSSGIKNG- Encephalitozoon_romaleae/568-774 ETSGANISGSS------------------FFYLLDPENNLPKTQDRMTKFLKSFGITNG- Giardia_lamblia/1424-1642 -----------------------------RRFLIDPLGDLKRTRERMKGLMLELPGNWDG Giardia_intestinalis/482-700 -----------------------------RRFLIDPLGDLRRTRERMKGLMLELPGNWDG Trypanosoma_brucei/897-1159 TLGQRNDSCHSSGDYIEKGGKNAAGCAGTVCCVIDPAGVMSKTLRRLLPLCSR--KG--- Trypanosoma_cruzi/861-1101 SKAESLDICDGG-----------------VYCVIDPAGDMPKTSKRLLPVCQR--TG--- Leishmania_major/1018-1279 HCSTDASAVSLQRLFVHRDDAALQHGPSSLTDLIAQHPRWEVVYGETLQAAAAAARDGSS Perkinsus_marinus/104-331 PDGAASAVGKG------------------GYYVIDPSGDLTESNKKLEPLLAGEF----- Cryptosporidium_muris/2563-2821 LRHFKSKLKHENSPYAVFSCRQCN-----LFYCINPTGDLIQTENLIVPYLKSIFRFSNQ Esp1_Cry_hominis/313-558 NQLQKSKESNLRLLANFCN----------IYYCINPTGDLEETEKTVIEFIKQKFGSKC- Cryptosporidium_parvum/2197-2442 NQLQKSKESNLRLLASFC----------NIYYCINPTGDLEETEKTVIEFIKQKFGSKCS Arabidopsis_thaliana/1873-2176 VLKKRSLQGEPAKSHVASFPLIDPLD---SFYLLNPGGDLTDTQVTFESWFRD--QN--- Medicago_truncatula/451-742 DKGSTSKEPVGRNLAPFPSIDPL-----DAFYLVNPDGDLAGTQIEFEKFFRDQNL---- Ricinus_communis/1862-2153 STLDRSCNNQEQVGRIFSAFPFIDPLD--AFYLLNPSGDLSSTQVEFENWFRDQNLEGK- Ostreococcus_tauri/1105-1323 GAVRRSKLDLSEIV---------------TYVRAQLSGELNNSSHMRYLTPLLAKAG--- Chlamydomonas_reinhardtii/2084-2337 GAAAAAFTSGGGRSSPAALPTS-------AFYLLNPSGDLADTQSAFQQLLEAQ-AG--- Volvox_carteri/1800-2079 SDLDGRVAALRHCGSRGMTVAGTSGSATSVFYVLNPSSDLVESQQFLQPILEAQ-AH--- Phaeodactylum_tricornutum/1780-2039 FSLKATKRALDLQR---------------VNYVVDPESNLPGTRQRIMPILDSLSQENDR Spironucleus_salmonicida/827-1043 RYLKTSQKMHITASEQLPPSTNLFFVDSSLPQTQIRIRELLNNQKQS------------- Blumeria_graminis/650-903 QQDDIRNDKSLAHYVDREKG----------SYILNPGGDLKHTLSTFEGKLQSLDG---- Caspase3_human/12-248 -----------------EDHSKRSSFVCVLLSHGEEGIIFGTNGPVD-----------LK caspase7_human/40-270 -----------------EDHTNAACFACILLSHGEENVIYGKDGVTP-----------IK Caspase1_Spod/28-272 -----------------MDHSDADCLLVAVLTHGELGMLYAKDTHYK------------P Caspase1_human/39-266 -----------------PEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDIL------QL Gingipain/139-360 ------------------------ISLVNYTGHGSETAWGTSH----------------- Homo_sapiens/1889-2119 -WRG--VVGEVPRPEQVQEALTKHD-LYIYAGHGAGARFLD------------------- Mus_musculus/1885-2117 -WKG--VIGEVPSLDQVQAALTERD-LYIYAGHGAGARFLDG------------------ Caenorhabditis_elegans/902-1153 -WEG--TVGSAPKSNEISAALSQRD-AFFFIGHGSGSSVM----PR-------------- Drosophila_melanogaster/360-634 -WQH--LFETVPNEEVMVKQALQAD-CFVYAGHGS-GLQY----VNG------------- Drosophila_virilis/366-640 -WEH--MYETVPSEQFMLEKAFKAD-CFVYAGHGSSLQYVSTR----------------- Drosophila_willistoni/360-635 -WRN---MFETVPTEDVIVKEVFKSKCFVYAGHGSGLQYISGR----------------- Shizosaccharomyces_pombe/1594-1828 -WKG--LIASQPSNRDFIKMLSGND-FFLYFGHGGGEQYTT------------------- Saccharomyces_cerevisiae/1391-1630 SQL----VMNEKPEEETLLKMLQNSNLFVYIGHGGGEQYVR------------------- Asp_nidulans/1828-2067 -WTG--MVNRQPTEDEFKDSLQSKS-LFLYFGHGSGAQYIRGR----------------- Exophalia_dermatidis/1807-2067 -FKA--IVNRPPGESEFEEALHNRP-LMLYFGHGGGAQYIRGC----------------- Encephalitozoon_hellem/566-772 ------GVTGRPLSDLECRKADRYD-VLLYFGHGNGLRYLKTSGEG-------------- Encephalitozoon_intestinalis/568-774 -------ITGRPPSDLECKEADGYD-VLLYFGHGSGLKYLKVSGEG-------------- Encephalitozoon_romaleae/568-774 -------VTGRSLSDLECREADKCD-ILLYFGHGSGLKYLKISGEG-------------- Giardia_lamblia/1424-1642 LLGK-AEEGSTHSRQPLALLKETADGVFFFAGHGCGEAVLPLN----------------- Giardia_intestinalis/482-700 LLGKV-EGGSADSRQPLALLKETADGVFFFAGHGCGEAVLPLN----------------- Trypanosoma_brucei/897-1159 -WVV-KSHNSPPSARLLREMYRAGVRLYVYVGHGKGEQIIQRG----------------- Trypanosoma_cruzi/861-1101 -WKT--STQSVPCGKLMHELYSYRAKAYFYVGHGKGERFLHRG----------------- Leishmania_major/1018-1279 AVTS---PLMRRLLSRCEAASDRID-TYVYAGHKGGEHLVPRG----------------- Perkinsus_marinus/104-331 -WEGR--SGVDPPVEEVVGALASRR-VFLYVGHSGGGQYWSTSG---------------- Cryptosporidium_muris/2563-2821 ---SGISNFIPNPKDILTNMSNEKSNLYLFCGHQAGEKFLPGEAFEKGIPSTRE------ Esp1_Cry_hominis/313-558 ---SGISNSIPQATEIMNTMSFNRSNLYLFCGHQAGEKFIQGELFERGIIT--------- Cryptosporidium_parvum/2197-2442 G---ISNSIPQATEIMNTMSFNRSN-LYLFCGHQAGEKFIQGELFERGIIT--------- Arabidopsis_thaliana/1873-2176 -FEG--KAGSEPSAIELTEALETHD-LFLYFGHGSGAQYIPR------------------ Medicago_truncatula/451-742 --EG--KAGSKPTVKELASALESHE-LFIYFGHGSGVQYISRREIEKLPQC--------- Ricinus_communis/1862-2153 -------AGCAPTAEELTSALKNHD-LFLYFGHGSGAQYISQQ----------------- Ostreococcus_tauri/1105-1323 -WDG--VIGTPPTVNEVRKAFQDVD-FYFYFGHGGGQDIIKIK----------------- Chlamydomonas_reinhardtii/2084-2337 -WQG--VVGQQPSARALLAALANHE-VFLFLGHGSGEQYLPLP----------------- Volvox_carteri/1800-2079 -WKG--ITGERPSTQALLTALQSHE-LFLYFGHGSGEQYLPLP----------------- Phaeodactylum_tricornutum/1780-2039 EWDG--IVGCEPSSLFFQKSLSMDSSLFLYFGHGGAEKYFSSKE---------------- Spironucleus_salmonicida/827-1043 -WVE--ITKPQAIIDSIKS-----TQHFIFAGHGGAENLLPHHK---------------- Blumeria_graminis/650-903 -WKG--ITNREPLEEEFRDFLQSTD-LFLYFGHGSGSQYIRARE---------------- Caspase3_human/12-248 KITNFFRGDRCRSLTGKP--KLFIIQACRGTELDCGIET----------DSGVDDDMACH caspase7_human/40-270 DLTAHFRGDRCKTLLEKP--KLFFIQACRGTELDDGIQ-----------------ANPRY Caspase1_Spod/28-272 DNLWYYFTADKCPTLAGKP-KLFFIQACQGDRLDGGITLSRTETD--------GSPSTSY Caspase1_human/39-266 NAIFNMLNTKNCPSLKDKP-KVIIIQACRGDSPGVVWF-----------------KDAIK Gingipain/139-360 FGTTHVKQLTNSNQL-----PFIFDVACV-------------NGDFLFSMPCFAEALMRA Homo_sapiens/1889-2119 -----GQAVLRLSCR-----AVALLFGCS-------------SAALAVHGNLEGAGIVLK Mus_musculus/1885-2117 ------QAVLRLSCR-----AVALLFGCS-------------SAALAVHGNLEGAGIVLK Caenorhabditis_elegans/902-1153 ------SVLKQSTCN-----AISLLMGCG-------------SVRTIPQALGFDGKTAIL Drosophila_melanogaster/360-634 ------RIICRARVR-----SVVFLFGCD-------------STRMLGTGLYSALYGAHD Drosophila_virilis/366-640 -------LIYRNRIK-----GVVFLFGCD-------------STRVLSSGLYSALYGAQD Drosophila_willistoni/360-635 -------TICRCRVE-----GIVFLFGCD-------------STKILGTGLHSALYGSHD Shizosaccharomyces_pombe/1594-1828 -----SYDLATLKRC-----AVTILMGCS-------------SGALYECGSFEPWGTPLD Saccharomyces_cerevisiae/1391-1630 -----SKEIKKCTKI-----APSFLLGCS-------------SAAMKYYGKLEPTGTIYT Asp_nidulans/1828-2067 -------TVKRLDRC-----AVAFLMGCS-------------SGTLTEAGEYEPYGTPMN Exophalia_dermatidis/1807-2067 -------KIRRMDKC-----AVTLLMGCS-------------SAKLTECGVYEPYGMPWN Encephalitozoon_hellem/566-772 --------------------KVMLLFGCN-------------SAKLLCIENYRRNGAILK Encephalitozoon_intestinalis/568-774 --------------------KIMFLFGCN-------------SAKLLCVENYKRNGSILK Encephalitozoon_romaleae/568-774 --------------------KIMLLFGCS-------------SAKLLCIENYKRNGAILK Giardia_lamblia/1424-1642 -------SIAELQQL-----PFCLFMGCS-------------SLSHIPVGHRYEVGTYQ- Giardia_intestinalis/482-700 -------SIAELQQL-----PFCLFMGCS-------------SLSHIPIGHRYEVGTYQ- Trypanosoma_brucei/897-1159 ---ELYERVPDPANF-----PSVFLMGCS-------------SAYMDGGLTYDCYGMPYA Trypanosoma_cruzi/861-1101 ------ELYERLPDPEEF--PAVFLMGCS-------------SAYMEGGASYDSYGMPYA Leishmania_major/1018-1279 ---ALYDWIPAAAGTPP---TLVLLMGCS-------------SARMQASALYDCFGLPFA Perkinsus_marinus/104-331 --------MEKRVLR-----ADALLMGCA---------SLRSSGTEGVRSRFEPIPPAYH Cryptosporidium_muris/2563-2821 --NFHFTNAKSNQIQVYNL-PPALLIGCS-------------SSRMRSYGSNECFCTPFH Esp1_Cry_hominis/313-558 ------ENFESENYHFYM--PPSLLIGCS-------------SSKIRSYGSNHVFFTPIH Cryptosporidium_parvum/2197-2442 ------ENLESENYHFYM--PPSLLIGCS-------------SSKIRSYGSNHVFFTPIH Arabidopsis_thaliana/1873-2176 ------REIEKLDNC-----SATFLMGCS-------------SGSLWLKGCYIPQGVPLS Medicago_truncatula/451-742 --------------------GATLLMGCS-------------SGSLTLNGSYAPQGVPLS Ricinus_communis/1862-2153 -------EIQKLENC-----AATLLMGCS-------------SGALSLNGSYIPHGTPLS Ostreococcus_tauri/1105-1323 ------TILDSCIR------SVMILMGCS-------------SGAYEYFDNLSPTSISML Chlamydomonas_reinhardtii/2084-2337 -------ALRKLQRC-----AAAVLMGCS-------------SGRLRLHGAYDPAGAVVA Volvox_carteri/1800-2079 -------ALRKLQRC-----ASCMLMGCS-------------SGRLRLHGAYDPSGAAVA Phaeodactylum_tricornutum/1780-2039 ---IFQFGVDKWKTHENIG-ASIVLMGCSSGRL-SSANQKGTKHTDDIPFFFEPGGVAIS Spironucleus_salmonicida/827-1043 -------ILQLESL------PEAAILGCSS---------------LCGNYFSGGRIRYTP Blumeria_graminis/650-903 -------IKKLLSC------AVTVLMGCSSGA---------LVETGEFEPYGPPMNYVHA Caspase3_human/12-248 KIPVEADFLYAYSTAPGYYS--WRNSKDGS-WFIQSLCAMLKQYA------------DKL caspase7_human/40-270 KIPVEADFLFAYSTVPGYYS--WRSPGRGS-WFVQALCSILEEHG------------KDL Caspase1_Spod/28-272 RIPVHADFLIAFSTVPGYFS--WRNTTRGS-WFMQALCEELRYAGTER---------DIL Caspase1_human/39-266 KAHIEKDFIAFCSSTPDNVS--WRHPTMGS-VFIGRLIEHMQEYACSC---------DVE Gingipain/139-360 QKDGKPTGTVAIIASTIDQY--WAPPMRGQDEMNEILCEKHPNNIKR----------TFG Homo_sapiens/1889-2119 -YIMAGCPLFLGNL--------WDVTDRDIDRYTEALLQGWLGAGPGAP---------LL Mus_musculus/1885-2117 -YIMAGCPLFLGNL--------WDVTDRDIDRYTEALLQGWLGAGPGAP---------FL Caenorhabditis_elegans/902-1153 DYAMAKCPLIVGCL--------WTVTDGEIDRFLIRMIDDCFEDSKSLTGI------DKL Drosophila_melanogaster/360-634 YYHGALCPSIVGTL--------MPALDGNMDTVSVTILSRWLAPGDNKVIPWTHIDRVPW Drosophila_virilis/366-640 YYHGALCPTVMGTL--------MPALDANMDNVSANMLSQWTKPANPQIVPWTHIDRQAW Drosophila_willistoni/360-635 YYHGALCPTIVGTL--------MPALDSNIDNISSSILSKFLAPSHRKVMPWSEIDTVTW Shizosaccharomyces_pombe/1594-1828 -YLSAGCPTLVANL--------WDVTDKDIDRFSLKMLESWGLF-ENKAPFVN----STS Saccharomyces_cerevisiae/1391-1630 -YLLGGCPMVLGNL--------WDVTDKDIDKFSEELFEKMGFRCNTDDLNGN----SLS Asp_nidulans/1828-2067 -YLQAGSPALVATL--------WDVTDKDIDRFAKATFEHWGLIGNGHRGNEGIGEAGVA Exophalia_dermatidis/1807-2067 -YLQAGSPAVVGNL--------WDVTDRDIDRFAMKLMNQWGLIQGTTEGGGSSAK-TGA Encephalitozoon_hellem/566-772 -HLGK-NSTVMGCL--------WEVTDKDIDNFSIKVIGGLVSGCSS----------LGE Encephalitozoon_intestinalis/568-774 -HLRR-NSMIVGCL--------WEVTDKDIDNFSVKVIESLINGSTN----------IGE Encephalitozoon_romaleae/568-774 -HLRK-NSTVVGCL--------WEVTDKDIDNFSIKIIEGLVNGCSN----------LGE Giardia_lamblia/1424-1642 -YYSSS-PLMLGTL--------WDGISGELDNITAHFMKQWTKGEKG----------LYS Giardia_intestinalis/482-700 -YYSSS-PLMLGTL--------WDGISGELDNITAHFMKQWTKGEKG----------LYS Trypanosoma_brucei/897-1159 -FLHAGAPLFVGCL--------WHVTDGEIDRLTKRLLSFVSYGGGSGDDFGVCR--TMA Trypanosoma_cruzi/861-1101 -FLHAGCPLFLGCL--------WHVTDGEIDRLTKRLLLLLAGEAVNDGDGASLLP-PRT Leishmania_major/1018-1279 -YLSAGVSCVLGCL--------WDVTDADIDRLTGRFLQVASQATANGEGIT-----VGE Perkinsus_marinus/104-331 -YLVGGSTRVVGTL--------WEVLGRECDLFCIELLRTWCVTPKVRDDDDCE---SAD Cryptosporidium_muris/2563-2821 -YLIGGSPFILGIL--------WDVTDHDIDLFTVSIFEIWSDYK------------NEH Esp1_Cry_hominis/313-558 -YLIGGSPLILGAL--------WDVTDQDIDRFTMSIFDNWVGSK------------LSL Cryptosporidium_parvum/2197-2442 -YLIGGSPLILGAL--------WDVTDQDIDRFTMSIFDNWVGSKLSLVESITLAKQE-- Arabidopsis_thaliana/1873-2176 -YLLGGSPAIVATL--------WDVTDRDIDRFGKALLEAWLQERSDSSSEGGCSQ-CES Medicago_truncatula/451-742 -YLLAGSPSIVANL--------WEVTDKDIDRFGKAMFDAWLKERSK------VDIQCLQ Ricinus_communis/1862-2153 -YLLAGSPVIVANL--------WEVTDKDIDRFGKVMLDAWLKERSIASSDCIQ---CNL Ostreococcus_tauri/1105-1323 -YLLCGAPTVLANL--------WDVTDVDIDRFSARLLQDWLSRTNSTDD-------MKT Chlamydomonas_reinhardtii/2084-2337 -YAVAGSPAVVANL--------WDVTDRDIDRYCQALLRNWLGCADPQAAAAAAAA-GQE Volvox_carteri/1800-2079 -YLLAGCPALVANL--------WDVTDRDIDRYAQALMHSWLGCTASTPSASTGSK-CGM Phaeodactylum_tricornutum/1780-2039 -YLAAGAPCVVGNL--------WDVTDRDIDRFSTDLIGTLFKGPGSPS--------LVS Spironucleus_salmonicida/827-1043 EKNWRHGSIVIGCL--------WDMLSGELDRFAQGYVDGGM---------------GIQ Blumeria_graminis/650-903 GS-----HAIVATL--------WDVTDKDIDRFAQSTFEHWG---------------LFS Caspase3_human/12-248 EFMHILTRVNRKVATEFESFSFDATFHAKKQI---------------------------- caspase7_human/40-270 EIMQILTRVNDRVARHFESQSDDPHFHEKKQI---------------------------- Caspase1_Spod/28-272 TLLTFVCQKVALDFESNAPDSAMMHQQKQV------------------------------ Caspase1_human/39-266 EIFRKVRFSFEQPDGRAQM----------------------------------------- Gingipain/139-360 GVTMNGMFAM-----------------------------------------------VEK Homo_sapiens/1889-2119 YYVNQARQAP-------------------------------------------------R Mus_musculus/1885-2117 YYASQARQAP-------------------------------------------------R Caenorhabditis_elegans/902-1153 RQLSEAMHEARSKA---------------------------------------------R Drosophila_melanogaster/360-634 LKNGIIKGKDETTPTMND-QPNYHLGSLCSILSLVQQGKVE-------------PNIYNC Drosophila_virilis/366-640 ISQGTVKALKGNTETLA-QQPDYQLGSLCAILANVHMGKTE-------------PKIYNC Drosophila_willistoni/360-635 VKKGLVQAQDESNPQYLDQYADYQMGSLPAIISRVQQGLID-------------PVIFNC Shizosaccharomyces_pombe/1594-1828 ICTAVSESRSC-----------------------------------------------CH Saccharomyces_cerevisiae/1391-1630 VSYAVSKSRGV-----------------------------------------------CH Asp_nidulans/1828-2067 LDAAVSQSRGA-----------------------------------------------CV Exophalia_dermatidis/1807-2067 TGKSGKTRSTEGEKMGAVSLDQAVAEARDE----------------------------CL Encephalitozoon_hellem/566-772 LVSRFRNE--------------------------------------------------FR Encephalitozoon_intestinalis/568-774 VVSRFRDE--------------------------------------------------FK Encephalitozoon_romaleae/568-774 LVSRYRNE--------------------------------------------------FR Giardia_lamblia/1424-1642 CLADAIAESS-------------------------------------------------- Giardia_intestinalis/482-700 CLADAIAESS-------------------------------------------------- Trypanosoma_brucei/897-1159 AGEALRLARKS-----------------------------------------------CK Trypanosoma_cruzi/861-1101 VGEALALARRA-----------------------------------------------CK Leishmania_major/1018-1279 CLAVARRA--------------------------------------------------CK Perkinsus_marinus/104-331 LPTSTRLARSK-----------------------------------------------VK Cryptosporidium_muris/2563-2821 SLSLLDAITISRNK--------------------------------------------CK Esp1_Cry_hominis/313-558 VESITLAKQE------------------------------------------------CK Cryptosporidium_parvum/2197-2442 ----------------------------------------------------------CK Arabidopsis_thaliana/1873-2176 LANDLAAMTLKGTKRSRKPSSRNKPAQSDVDGSGKIECNHKHRRKIGSFIAAARDA--CN Medicago_truncatula/451-742 CNLLSEELEAMNLKGGKGRGKRKVPKKKSLELPENDSLSTKCNHRRKIGAFMGQARNVCK Ricinus_communis/1862-2153 LAEEFEAMNLKDRKVATKKRVQKKKEPETCDGDALKNSCNHRPKIGSFMSQAREA---CR Ostreococcus_tauri/1105-1323 FYRFSTSLQDARNA--------------------------------------------CR Chlamydomonas_reinhardtii/2084-2337 DEEQEAQPVGWAGLGQAVVSSRGA----------------------------------CR Volvox_carteri/1800-2079 AGGAKRERPCSDVGPSEPLGLAVTRSRSA-----------------------------CK Phaeodactylum_tricornutum/1780-2039 CVCSSRAA--------------------------------------------------CR Spironucleus_salmonicida/827-1043 GSFQGRKK--------------------------------------------------ML Blumeria_graminis/650-903 ASTPCRSGLQDHQRSAGSAPKMSLVEAVARGRKACTLRYLN-----------------AA Caspase3_human/12-248 ------------PCIVSMLTKELYFY------------ caspase7_human/40-270 ------------PCVVSMLTKELYFSQ----------- Caspase1_Spod/28-272 ------------PCITSMLTRLLVFGKKQSHL------ Caspase1_human/39-266 ------------PTTERVTLTRCFYLFPGH-------- Gingipain/139-360 YKKDGENMLD--TWTVFGDPSLLVRTLVPTEMQVTAPA Homo_sapiens/1889-2119 LKYLIGAA----PI-AYGLPVSLR-------------- Mus_musculus/1885-2117 LKYLIGAA----PV-AYGLPISLQTP------------ Caenorhabditis_elegans/902-1153 LKYLTGA-----AVVMYGLPVVAKQTTPFVEKDQRNLP Drosophila_melanogaster/360-634 CIYVCRGL----PAWNLAVEKLPL-------------- Drosophila_virilis/366-640 CVYVCRGL----PAWNLAVQQLPF-------------- Drosophila_willistoni/360-635 CIYVCRGL----PAWNLSVQKMPF-------------- Shizosaccharomyces_pombe/1594-1828 LRYLNGAA----PV-IYGIPAYIIP------------- Saccharomyces_cerevisiae/1391-1630 LRYLNGAA----PV-IYGLPIKFVS------------- Asp_nidulans/1828-2067 LKYLNGAA----PV-VYGVPGVFLH------------- Exophalia_dermatidis/1807-2067 LKYLNGAA----PV-MYGVPVFLK-------------- Encephalitozoon_hellem/566-772 LRYLNGA-----SVVIYGVC------------------ Encephalitozoon_intestinalis/568-774 LRYLNGA-----SVVIYGFR------------------ Encephalitozoon_romaleae/568-774 LRYLNGA-----SVVIYGVH------------------ Giardia_lamblia/1424-1642 LRYLVGY-----SIIIIGDPNTKYMC------------ Giardia_intestinalis/482-700 LRYLVGY-----SIIIIGDSSTKYMC------------ Trypanosoma_brucei/897-1159 LPYLTGC-----ATVLYGMNLPLGGTPGGAM------- Trypanosoma_cruzi/861-1101 LPFLTGC-----AAVLYGTNLSLERTVDG--------- Leishmania_major/1018-1279 LHYLTGM-----ATVFYGVNCYVTAAREDDSKGAA--- Perkinsus_marinus/104-331 LELLSGG-----AFVCYASRII---------------- Cryptosporidium_muris/2563-2821 LQLLNGN-----SCICFGFPV----------------- Esp1_Cry_hominis/313-558 LPLLNGS-----SCVCFGYPI----------------- Cryptosporidium_parvum/2197-2442 LPLLNGS-----SCVCFGYPI----------------- Arabidopsis_thaliana/1873-2176 LQYLIGAA----PV-CYGVPTGITRKKGIDALLPSSSR Medicago_truncatula/451-742 LPFLIGA----SPV-CYGVPTGIWRKKDT--------- Ricinus_communis/1862-2153 LPYLIGAS----PV-CYGVPTGIRRKKDL--------- Ostreococcus_tauri/1105-1323 LKHLVGAA----PV-LYGVPAVLDD------------- Chlamydomonas_reinhardtii/2084-2337 LPHLIGAA----PV-CYGLPLHQ--------------- Volvox_carteri/1800-2079 LTHLIGAA----PV-CYGLPFGR--------------- Phaeodactylum_tricornutum/1780-2039 MQHIVGCA----PV-CYGIPVPVLEHTDLRDHLR---- Spironucleus_salmonicida/827-1043 LKSVFGV-----GIVVYG-------------------- Blumeria_graminis/650-903 AVCVYGV-----PVYLHD--------------------