CLUSTAL Homo_sapiens/1748-1889 ----------------HLRSVLNEFDAIQKAQKENSS----------------------- Mus_musculus/1744-1885 ----------------PLSAVLKEFDAIQKDQKENSS----------------------- Caenorhabditis_elegans/755-902 -----------VELMDKFTFLLDEDEMIAKYPG--------------------------- SEP-2_Celegans/779-925 -------------VMDKFTYLLEEDRQIVSNHEK-------------------------- Drosophila_melanogaster/199-360 ---------------ENTANLFREYSTLVERFRRVVTVDPLNMKG--------------- Drosophila_virilis/198-366 ----------------AMASLFKAYGTLVERFRRVVTVDPLTVKA--------------- Drosophila_willistoni/200-360 ---------------ERLVEVFQEYSTLVERFRRVVNVDPILAKN--------------- Shizosaccharomyces_pombe/1421-1594 ----------FTKAQTELFRIISKSNQMAQNGKHYT------------------------ Saccharomyces_cerevisiae/1215-1391 -----------PEATKKLLSIINESNQTTSVEVTNKI----------------------- Exophalia_dermatidis/1630-1807 ---------------AELQDIIAQANSSSHDPRG-------------------------- Encephalitozoon_hellem/504-566 -------------------GFKDAKARINRILAKSRSILRE------------------- Encephalitozoon_intestinalis/506-568 -------------------GFGDTKVKMNEILAKSRNVLKG------------------- Encephalitozoon_romaleae/506-568 -------------------GFRDVKARISRILIESRNILKE------------------- Giardia_lamblia/1132-1317 ---------WLGTLAHLHGNILRALFFSHAAALSTLETSKSTES---------------- Giardia_intestinalis/190-375 ---------WLGTLAHLHGNILRALFFSHAAALSTLETSKPTES---------------- Trypanosoma_brucei/642-878 ---------TRWEKVLRIEYLLLQLVEEMKIIERRNRDHLRSTDQGESPLCED-----LP Trypanosoma_cruzi/622-853 --------TVWEKVLPVGRTLLEMVARMREIEAQNRRHLEATLYNKEVSLLG------KE Leishmania_major/760-957 -----------------TGRFLDSQGQRELTASTSSACQRAGDGAAAPTETD-------- Perkinsus_marinus/1-104 ------------------MADVRQAVE--------------------------------- Cryptosporidium_muris/2336-2494 ----------------TLESLLEEYEQIQKENLASIVTNEPIDNNQLSKECLPNYSHK-- Esp1_Cry_hominis/165-313 -----------------TNELLEEFDNIQRMNTESIIKIDINTN---------------- Cryptosporidium_parvum/2049-2197 -----------------ANELLEEFDNIQRMNTESIIKIDVNTN---------------- Arabidopsis_thaliana/1696-1873 --------TVVDEVAPAFKSILEESHSSSST----------------------------- Medicago_truncatula/277-451 --------TMVDDIAPAFKTILKENYSSSTSLFETT------------------------ Ricinus_communis/1687-1862 ---------TVIDEVSPAFKLILEENYLSSSIFPLEDT---------------------- Ostreococcus_tauri/980-1104 ------------------PALRDVFTKFADTLARQH------------------------ Chlamydomonas_reinhardtii/1723-1889 -----------------LQRLLEDSGDSMR------------------------------ Volvox_carteri/1510-1674 -----------------LHQLLEESGDSMH------------------------------ Phaeodactylum_tricornutum/1669-1780 ----------------PFDRIMQRNQDQLDGGSPGSKEFDL------------------- 4EWI:A/1-113 --------GSMAASFFSDFGLMWYLEEL-------------------------------- 2KM6/1-100 ---------GHMTSPQLEWTLQTLLEQLNE------------------------------ 3KAT_NLRP-1/9-107 SHSPLDAPQLLHFVDQYREQLIARVT---------------------------------- 2L9M_cIAP-1/7-132 AEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLT----------------------- 1A1W/1-85 -------------MDPFLVLLHSVSSSL-------------------------------- 1YGO/1-110 GSHMSHLDNTMAIRLLPLPVRAQLCAHLDALDV--------------------------- 1CWW_Apaf-1/1-102 --------GPLGSMDAKARNCLLQHREALEKDIK-------------------------- 2LWD_RIG-1/1-100 -----GSHMKKIEKLEEYRLLLKRLQPEFKTRII-------------------------- CARD_Casp8/1-94 ----------------VDAAFVKENHRQLQARMGDLK----------------------- 3CRD_RAIDD/1-100 -------------MEARDKQVLRSLRLELGAEVL-------------------------- Ced3_CARD/1-91 -------------MRQDRRSLLERNIMMFSSHLK-------------------------- E10_equid_herpes_virus/1-91 -------------IWDVERLCLEELRVLLVSHLK-------------------------- 3YGS_CARD_casp9/1-97 ------------SMDEADRRLLRRCRLRLVEELQVDQ----------------------- Homo_sapiens/1748-1889 --------------------------CTDKREWWTGRLALDHRME-VLIASLEKSVL-GC Mus_musculus/1744-1885 --------------------------CTEKRVWWTGRLALDQRME-ALITALEEQVL-GC Caenorhabditis_elegans/755-902 --------------------------DITPEEFWKRRKIVDGRMM-TFVDEVQKHFL-GV SEP-2_Celegans/779-925 ---------------------------YKFEECWDRRKIVDCQMK-KCVENTQKHFL-GA Drosophila_melanogaster/199-360 --------------------------KEAKQKYWEELNGFDTFQQ-KLLADFRD-IISP- Drosophila_virilis/198-366 --------------------------QEAKAKYWKEVNAFEEFLK-KLIADLGS-VFSP- Drosophila_willistoni/200-360 --------------------------KETKRKYWVDLHEFGKVLE-KLIADLREIILP-- Shizosaccharomyces_pombe/1421-1594 -------------------------RREDKETWWKERRHLDQCLQ-QLLENIEISWL-GG Saccharomyces_cerevisiae/1215-1391 ------------------------KTREERKSWWTTRYDLDKRMQ-QLLNNIENSWFNGV Exophalia_dermatidis/1630-1807 ----------------------CSADKSLRKAWYNERKALDQQLA-TLLDNMENVWF-GG Encephalitozoon_hellem/504-566 ----------------------NVSNNVDKAMWWMKRMELDAELGEILHETSTK-----F Encephalitozoon_intestinalis/506-568 ----------------------NVTSDLDKARWWMERMELDTQLGEILRSVGDK-----F Encephalitozoon_romaleae/506-568 ----------------------NVHNDVDKARWWMQRIELDTKLGEVLHSVSTK-----F Giardia_lamblia/1132-1317 ----------------------------DKAQWAKTLVTADTEMQ-KCATQLLPAFI-GA Giardia_intestinalis/190-375 ----------------------------DKAQWAKTLIIANAEMQ-KCATQLLPAFI-GA Trypanosoma_brucei/642-878 VSSLRSDISVGPVCCSVG---GAQDARKAREEWWNERRALDRSIG-AVVQSMQSPEGFGC Trypanosoma_cruzi/622-853 KMEAPSDATEAFSNSEVE-----RQSRKARAEWWEQRQAFDSAIR-KVVEKLQSDECFGC Leishmania_major/760-957 ----------------------AQRQRRRKEAWWCERFELDDRIG-RVAASMQDAL--GA Perkinsus_marinus/1-104 -------------------------SKQDGSKFWRNRENFEGRAQ-KALERLKKDLL-GD Cryptosporidium_muris/2336-2494 ---------------------------LYVNKWWLKRKNIQDQLK-IWLVKFEALIF-NK Esp1_Cry_hominis/165-313 -------------------------SSEQTRKWWNRRIYIESRLN-SWLNKFSNQILKG- Cryptosporidium_parvum/2049-2197 -------------------------SSEQTRKWWNRRIYIESRLN-SWLNKFSNQILKG- Arabidopsis_thaliana/1696-1873 ---------------------TEEDTIESRGLWWKKRKKLNHRLG-IFLRNLEASWL-GP Medicago_truncatula/277-451 --------------------------EQNMRLWWDWRINVDRRLA-KFLRNLEDLWF-GS Ricinus_communis/1687-1862 --------------------------KENRTLWWMRRKKLDFQLG-KLLRKMEDLWL-GP Ostreococcus_tauri/980-1104 ------------------DTPEESCSRESKLIWWETRILLDARLH-ESLDQMNANIL-GP Chlamydomonas_reinhardtii/1723-1889 ------------------TDQAAASSQNQKAQWWKARTALDASVS-KLLQQLDSDCL-GA Volvox_carteri/1510-1674 ------------------MDQDAASSQSHKVKWWKTRVSLDEGVR-GLLQELDEQCL-GP Phaeodactylum_tricornutum/1669-1780 ------------------------TEKERKKGWWKDREELDTDLL-HLLQSVDRKTF--- 4EWI:A/1-113 --------------------------------KKEEFRKFKEHLKQMTLQLE-------- 2KM6/1-100 ----------------------------------DELKSFKSLLWAFPLED--------- 3KAT_NLRP-1/9-107 ----------------------------------SVEVVLDKLHGQVL------------ 2L9M_cIAP-1/7-132 ----------------------------------CVLPILDNLLKANVI----------- 1A1W/1-85 --------------------------------SSSELTELKYLCLGRVGK---------- 1YGO/1-110 ------------------------------------WQQLATAVKL-------------- 1CWW_Apaf-1/1-102 -----------------------------------TSYIMDHMISDGFL----------- 2LWD_RIG-1/1-100 -----------------------------------PTDIISDLSECL------------- CARD_Casp8/1-94 -------------------------------------GVLDDLQDNEVL----------- 3CRD_RAIDD/1-100 ----------------------------------VEGLVLQYLYQEGIL----------- Ced3_CARD/1-91 -----------------------------------VDEILEVLIAKQVL----------- E10_equid_herpes_virus/1-91 -----------------------------------SHKHLDHLRAKKIL----------- 3YGS_CARD_casp9/1-97 --------------------------------------LWDVLLSRELFR---------- Homo_sapiens/1748-1889 WKGLLLPSSEEPG----PAQEASRLQELLQDCGWKYPD-------------RTLLKIMLS Mus_musculus/1744-1885 WRGLLLPCSADPS----LAQEASKLQELLRECGWEYPD-------------STLLKVILS Caenorhabditis_elegans/755-902 AASLLMPSGQLGP---KAAELAIKIHKLSKGGLLL-------------GEAKEMVYQSKL SEP-2_Celegans/779-925 AASLLLPSGRLGP---NATALAIKMYNMAKGGLLP-------------GEAKELVYQSKF Drosophila_melanogaster/199-360 YSFLFFGKRYDC-----TVVQKQIKATYTRVDDFCLLNQWGT-------HQRVLLSQAAS Drosophila_virilis/198-366 YSYVFLGKRYPS-----AAVQQQTKAVYGRVDEFCVQHSWSN-------HQRVLLSQAAL Drosophila_willistoni/200-360 YAFLFLGKRYAT-----KSVTKLSQQIFREVDEFCEQHKWNQ-------HQRIILSQAAY Shizosaccharomyces_pombe/1421-1594 FKGIFNPHKID------TSLFAKFSSQFQNIIAKNFNMDKKTPVPTLS---PEILELFIT Saccharomyces_cerevisiae/1215-1391 QGFFSPEVVDNSLFE---KFKDKFYEILHQNLPSRKLYGNPAMFIKVED---WVIELFLK Exophalia_dermatidis/1630-1807 FRGLLSAPEIDDNAL--LRFGQSFSKMLNRHLPSRRKASKSVDTKIEL--HSHVLELFVT Encephalitozoon_hellem/504-566 AG-LLARK---------------------------------------------------- Encephalitozoon_intestinalis/506-568 DR-LSIGK---------------------------------------------------- Encephalitozoon_romaleae/506-568 DG-LFTRK---------------------------------------------------- Giardia_lamblia/1132-1317 WRG-LLDPKYNL-----DSCTHLLRETLRGAPVREYECIQP-----DILELYRLLMEVVS Giardia_intestinalis/190-375 WKG-LLDPKYNL-----DICTHLLRDTLRGESVCEYECIQS-----DILEIYRLLMEVMS Trypanosoma_brucei/642-878 WRAALCGELPD---SCQVAVWDATKELLSGLGLPAQHEGDV-------SLVLAALPFVGD Trypanosoma_cruzi/622-853 WRVAMCGDLPP---SCLLELKRVAAQLIHDIGAPAHHMLDV-------TLILAGLPFLGT Leishmania_major/760-957 AHMLLLGYPSTSLG---GQLQTLAARFACECVRLRGASHCP---------PMDALQHVTL Perkinsus_marinus/1-104 WSALLLLGGGPCVSP---GVYLESHDNLPDDLASRKRIQ--------------SLRAVV- Cryptosporidium_muris/2336-2494 WNFLLHGWPKY-------FNYENLIDTINNQYII---------------SQKELLFINSK Esp1_Cry_hominis/165-313 WTSKLFYGWRKE------LNSEKNIKQVAEFIKTYLIDID-----------QSLIGIIIF Cryptosporidium_parvum/2049-2197 WTSKLFYGWRKE------LNSEKNIKQVAEFIKTYLIDID-----------QSLIGIIIF Arabidopsis_thaliana/1696-1873 WRCLLLGEWSNYK-----LPDSAQKKLVNDLKSKCKMEVN-----------EMLLKVILG Medicago_truncatula/277-451 WKFLLLGEWSNCN-----FFDSVLKNLVNDLRSKCKLNVN-----------EGLLKIILG Ricinus_communis/1687-1862 WRCVLLGELSDSK-----HLDSVQKKLMRNLKSKCKVDVN-----------ESFLKVILG Ostreococcus_tauri/980-1104 WRVLLLG----------RASDQ-VRGLIEDTTRAVVVRLK-------AIALRDNLQLASS Chlamydomonas_reinhardtii/1723-1889 WRCLLLPLPASH----RGVLAGAAAAFVGEHVTGGGAAP-------AAGIATAVAQELLT Volvox_carteri/1510-1674 WRCLLLSVPNAH----LEVWRAAADAFIAEHFPSVHSSGEGHCGS-----PAAVLRELVI Phaeodactylum_tricornutum/1669-1780 -------------------GSDFIQSFF-------------------TNNRGNTSSYVG- 4EWI:A/1-113 ---------------LKQIPWTEVKKAS----------------------REELANLLIK 2KM6/1-100 --------------VLQKTPWSEVEEAD----------------------GKKLAEILVN 3KAT_NLRP-1/9-107 -------------------SQEQYERVLAENT-----------------RPSQMRKLFSL 2L9M_cIAP-1/7-132 --------------------NKQEHDIIKQKT-------------QIPLQARELIDTILV 1A1W/1-85 ---------------------RKLERVQSG-----------------LDLFSMLLEQNDL 1YGO/1-110 -------------------YPDQVEQISSQKQRGR-------------SASNEFLNIWGG 1CWW_Apaf-1/1-102 -------------------TISEEEKVRNEP--------------TQQQRAAMLIKMILK 2LWD_RIG-1/1-100 ----------------INQECEEILQICSTK------------------GMMAGAEKLVE CARD_Casp8/1-94 --------------------TENEKELVEQEKTRQ-------------SKNEALLSMVEK 3CRD_RAIDD/1-100 -------------------TENHIQEINAQTTGL--------------RKTMLLLDILPS Ced3_CARD/1-91 ----------------NSDNGDMINSCGTVRE-----------------KRREIVKAVQR E10_equid_herpes_virus/1-91 -------------------SREDAEEVSSRATSR---------------SRAGLLVDMCQ 3YGS_CARD_casp9/1-97 --------------------PHMIEDIQRAGSGS------------RRDQARQLIIDLET Homo_sapiens/1748-1889 GAGAL-----------------------------TPQDIQALAYGLCPTQP--------- Mus_musculus/1744-1885 GARIL-----------------------------TSQDVQALACGLCPAQP--------- Caenorhabditis_elegans/755-902 M---------------------------------DAKSWEALILRFCEMRT--------- SEP-2_Celegans/779-925 IH---------------------------------PKTWKSLVLRYCEMRG--------- Drosophila_melanogaster/199-360 HANRLE-----------------------------IADLKLICYELSSNENEI------- Drosophila_virilis/198-366 HANRL-----------------------------PRDQMKQLSYELSGNSQNNNNN---- Drosophila_willistoni/200-360 HANHIK-----------------------------KADIAVLSWKLASD----------- Shizosaccharomyces_pombe/1421-1594 LGKPGYEG------------------------------YEQLLEDLIYFILDIFQFRGLH Saccharomyces_cerevisiae/1215-1391 LNPQEIDFLSKMEDLI----------------------YFVLDILLFHGEENAY------ Exophalia_dermatidis/1630-1807 LGHPREAELE-----------------------------DAIVDLLYFVIDILQFNGERN Encephalitozoon_hellem/504-566 ------------------------------------------------------------ Encephalitozoon_intestinalis/506-568 ------------------------------------------------------------ Encephalitozoon_romaleae/506-568 ------------------------------------------------------------ Giardia_lamblia/1132-1317 LAIEPMKDLSSVSANTGKDS------------------VFSLTILGLMGIPRGGASDLD- Giardia_intestinalis/190-375 LAIEPLKSLSSVTASVGKES------------------AFSLTILGLMGISRGGNSDLE- Trypanosoma_brucei/642-878 RHPEDGDLLFNPSHVGPTNP-----------CGCCDETLRRLSTALEQELITHLDAKLVN Trypanosoma_cruzi/622-853 RFCAGGKLLFSPSHGSAEGK-----------CASCDEVLCNLSGALEIELLKNGIAAPST Leishmania_major/760-957 QVLAAAPYLWKDETPPRGQTTCWYGPRNARSCACCMQTVKRAHRMLLEAVTALGQLVAAA Perkinsus_marinus/1-104 ----------------------------------------ELDAANERS----------- Cryptosporidium_muris/2336-2494 SSEVRKSNRR------------------------NAKNTSNILNTTDLTIYNTN------ Esp1_Cry_hominis/165-313 SLTNNI---------------------------------PQILNLLKSDNILNFNLKDIC Cryptosporidium_parvum/2049-2197 SLTNNI---------------------------------PQILNLLESDNILNFNLKDIC Arabidopsis_thaliana/1696-1873 GGTDNFKGEACV-------------------------AQLSLRNGCYVGRGGYLYEEDSC Medicago_truncatula/277-451 GSKYVCEGKSLL-------------------------PQLCSKKDCYIAKGGYCDGAKSG Ricinus_communis/1687-1862 GGKSVLDAEACI------------------------YDILFLKKGCFIGKVIYSDEETCK Ostreococcus_tauri/980-1104 AYE------------------------------------LTFLMLSGAHSL--------- Chlamydomonas_reinhardtii/1723-1889 VAMAN-MGQLGSNEV------------------------GTVLRTVCGGISGGTSCN--- Volvox_carteri/1510-1674 IALSSMRHMK-------------------------GGDLAALLGIICNQLGLHGGQSL-- Phaeodactylum_tricornutum/1669-1780 ----------------------------------------SLASRFDAVSDDKDQIS--- 4EWI:A/1-113 H-------------------------------YEEQQAWNITLRIFQKMD---------- 2KM6/1-100 -------------------------------TSSENWIRNATVNILEEMNLTE------- 3KAT_NLRP-1/9-107 SQSWDR------------------------------KCKDGLYQALKETHPH-------- 2L9M_cIAP-1/7-132 K---------------------------------GNAAANIFKNCLKEI----------- 1A1W/1-85 EPGHT----------------------------------ELLRELLASLRRH-------- 1YGO/1-110 QYNH--------------------------------TVQTLFA-LFKKLK---------- 1CWW_Apaf-1/1-102 K---------------------------------DNDSYVSFYNALLHEG---------- 2LWD_RIG-1/1-100 CLLRSDK----------------------------ENWPKTLKLALEKERN--------- CARD_Casp8/1-94 K---------------------------------GDLALDVLFRSISERD---------- 3CRD_RAIDD/1-100 RGPK---------------------------------AFDTFLDSLQEF----------- Ced3_CARD/1-91 RGDV---------------------------------AFDAFYDALRST----------- E10_equid_herpes_virus/1-91 DHPR---------------------------------GFQCLKESCKN------------ 3YGS_CARD_casp9/1-97 RGSQ----------------------------------ALPLFISCLEDTGQ-------- Homo_sapiens/1748-1889 -----------------ERAQELLNEAVGRLQGLTVPSNS---------- Mus_musculus/1744-1885 -----------------DRAQVLLSEAVGQVQSQEAPRSQ---------- Caenorhabditis_elegans/755-902 ---------------TDEKFKSFLPLMHRNSVEVMNQDDSIVTEKK---- SEP-2_Celegans/779-925 -------------IDNKSKSQLLLLRKDGFNAMKQDQTIPASSKI----- Drosophila_melanogaster/199-360 -----------------QSAYELLKGLASDWAEVEERQPLASRRF----- Drosophila_virilis/198-366 ------------NETEALLVYELLKSCASDWQQLEQREPLAAKRF----- Drosophila_willistoni/200-360 ------------NEEAMQLVEDLLNKWSQNWEELKELSSHKRF------- Shizosaccharomyces_pombe/1421-1594 FAYDEI------------DTDQLSMDLQDALNAYFNNYVSEENRS----- Saccharomyces_cerevisiae/1215-1391 --------------DEIDF-SMLHVQLEEQIKKYRATMTTNSIF------ Exophalia_dermatidis/1630-1807 AY------------DEIDFDAMLVEVLDALHSYHEEHSRRAQENPNS--- Encephalitozoon_hellem/504-566 -------------------------------------------------- Encephalitozoon_intestinalis/506-568 -------------------------------------------------- Encephalitozoon_romaleae/506-568 -------------------------------------------------- Giardia_lamblia/1132-1317 ---------------LIIVSLTLIVGLLSDLSTFAIPSASLASSH----- Giardia_intestinalis/190-375 ---------------LIIVSLTLIVGILSDLSTFALPSANLACSY----- Trypanosoma_brucei/642-878 EP--------------TACRKACLHVLTAMHAVISEKKCNQPVDHGGEP- Trypanosoma_cruzi/622-853 -----------------GLLSVLRGACLCALATMCKTISVACESELGHLD Leishmania_major/760-957 TAAATESSL----------SCALASEPAN--------------------- Perkinsus_marinus/1-104 ---------------------PVSAVGPRVS------------------- Cryptosporidium_muris/2336-2494 -----------------DEEKALIEISILILLTK---------------- Esp1_Cry_hominis/165-313 -----------------VKFKKIKFQSIKNKVENF--------------- Cryptosporidium_parvum/2049-2197 -----------------VKFKKIKFQSIKNKVENF--------------- Arabidopsis_thaliana/1696-1873 KTPTAASNISESRHE---LALKLIHDAASKLGQQDGHENRE--------- Medicago_truncatula/277-451 IFSNVANKLMSSE-----VAFELLNEALNVLEVDDSMNRE---------- Ricinus_communis/1687-1862 ILTKEFGVQKLPN-----LAIQLIHEAVNELEVDIVTRE----------- Ostreococcus_tauri/980-1104 ------------------SDGELHTAFA---------------------- Chlamydomonas_reinhardtii/1723-1889 -----------------TDVAALAAELAAAQAAACMALLHLPQPAAGPTA Volvox_carteri/1510-1674 -------------------TTGLVMEFAAAEAAARVQLLKLPPDEQ---- Phaeodactylum_tricornutum/1669-1780 --------------------AEAKKGVPFGMSTLNE-------------- 4EWI:A/1-113 -------------------RKDLCMKVMRERTGYTKTYQAHAKQKFSRLE 2KM6/1-100 ----------------------LCKMAKAEMMEDGQLE------------ 3KAT_NLRP-1/9-107 ------------------LIMELWEKGSKKG------------------- 2L9M_cIAP-1/7-132 -------------------DSTLYKNLFVDKNMKYIPTEDVSGLSLEEQL 1A1W/1-85 ---------------------DLLRRVDDFELE----------------- 1YGO/1-110 -------------------LHNAMRLIKDYVSEDLHKYIPR--------- 1CWW_Apaf-1/1-102 -------------------YKDLAALLHDGIPVVSSS------------- 2LWD_RIG-1/1-100 ------------------KFSELWIVEK---------------------- CARD_Casp8/1-94 --------------------PYLVSYLRQQNLAAALE------------- 3CRD_RAIDD/1-100 --------------------PWVREKLKKAREEAMTDLPAG--------- Ced3_CARD/1-91 ------------------GHEGLAEVLEP--------------------- E10_equid_herpes_virus/1-91 ----------------EVGQEHLVDLLER--------------------- 3YGS_CARD_casp9/1-97 --------------------DMLASFLRTNRQAG----------------