Supp. Table S2.
M-Coffee Multiple Sequence Alignments of LQT proteins and their paralogues.
Multiple sequence alignments for the eight LQT proteins and their paralogues are shown below, as generated using
M-Coffee.
The average consistency (0-100) of pairwise alignments is shown for each protein in the alignment, followed by the aligned sequences.
Colour-coding indicates agreement between different alignment algorithms used by M-Coffee,
red indicating perfect agreement and blue indicating poor agreement.
KCNQ1 - KCNH2 - SCN5A - ANK2 -
KCNE1 - KCNE2 - KCNJ2 - CACNA1C
KCNQ1 Paralogue Multiple Sequence Alignment
T-COFFEE, Version_8.99(Thu Feb 17 19:24:49 CET 2011 - Revision 594)
Cedric Notredame
CPU TIME:6 sec.
SCORE=57
*
BAD AVG GOOD
*
KCNQ1 : 59
KCNQ2 : 44
KCNQ3 : 45
KCNQ4 : 46
KCNQ5 : 44
KCNA1 : 55
KCNA2 : 74
KCNA3 : 65
KCNA4 : 63
KCNA5 : 60
KCNA6 : 65
KCNA7 : 72
KCNA10 : 69
KCNB1 : 47
KCNB2 : 46
KCNC1 : 52
KCNC2 : 52
KCNC3 : 46
KCNC4 : 51
KCND1 : 54
KCND2 : 54
KCND3 : 53
KCNF1 : 64
KCNG1 : 62
KCNG2 : 67
KCNG3 : 70
KCNG4 : 62
KCNV1 : 63
KCNV2 : 62
KCNS1 : 62
KCNS2 : 64
KCNS3 : 63
cons : 57
KCNQ1 1 MA-----------------------------------A---- 3
KCNQ2 1 ------------------------------------------ 0
KCNQ3 1 ------------------------------------------ 0
KCNQ4 1 ------------------------------------------ 0
KCNQ5 1 M------------------------------------P---- 2
KCNA1 1 ------------------------------------------ 0
KCNA2 1 ------------------------------------------ 0
KCNA3 1 MD-----ERLSLLRSPPPPSARHRAHPPQRPASSG-GAHTLV 36
KCNA4 1 ME-----VAMV-------------------SAESS-GCNSHM 17
KCNA5 1 ME-----IALV-------------------PLENG-GAMTVR 17
KCNA6 1 MR-----SEKS-------------------LTLAA------- 11
KCNA7 1 M----------------------------------------- 1
KCNA10 1 MD-----VC-GWK------------------EMEV-ALVNFD 17
KCNB1 1 M----------------------------------------- 1
KCNB2 1 MA---------------------------------------- 2
KCNC1 1 ------------------------------------------ 0
KCNC2 1 ------------------------------------------ 0
KCNC3 1 ML-----SSVCV-------------------SSF-------- 10
KCNC4 1 MI-----SSVCV-------------------SSY-------- 10
KCND1 1 MA-----AGLAT-------------------WLP-------- 10
KCND2 1 MA-----AGVAA-------------------WLP-------- 10
KCND3 1 MA-----AGVAA-------------------WLP-------- 10
KCNF1 1 MD---------------------------------------- 2
KCNG1 1 MT-----LLPGD-------------------NSD-YDYSALS 17
KCNG2 1 ------------------------------------------ 0
KCNG3 1 MT-----FG--------------------------------- 4
KCNG4 1 MP-----MPSRD-------------------GGLHPRHHHYG 18
KCNV1 1 MP---------------------------------------- 2
KCNV2 1 MLKQSERRRSWS-------------------YRPW-NTTENE 22
KCNS1 1 ML---------------------------------------- 2
KCNS2 1 MT---------------------------------------- 2
KCNS3 1 MV---------------------------------------- 2
cons 1 42
KCNQ1 4 ------------------------------------------ 3
KCNQ2 1 ------------------------------------------ 0
KCNQ3 1 ------------------------------------------ 0
KCNQ4 1 ------------------------------------------ 0
KCNQ5 3 ----------------------------------RHHA--GG 8
KCNA1 1 ------------------------------------------ 0
KCNA2 1 ------------------------------------------ 0
KCNA3 37 NHGYAE------------------------------------ 42
KCNA4 18 PYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGSGGSGG 59
KCNA5 18 GG----------------DEARAGCGQATGG-ELQCPPTAGL 42
KCNA6 12 -P----------------GEV-------------------RG 17
KCNA7 2 ------------------------------------------ 1
KCNA10 18 NS----------------D-------------EIQEEP--GY 28
KCNB1 2 ------------------------------------------ 1
KCNB2 3 ------------------------------------------ 2
KCNC1 1 ------------------------------------------ 0
KCNC2 1 ------------------------------------------ 0
KCNC3 11 -R----------------GR---------------------- 13
KCNC4 11 -R----------------GR---------------------- 13
KCND1 11 ------------------------------------------ 10
KCND2 11 ------------------------------------------ 10
KCND3 11 ------------------------------------------ 10
KCNF1 3 ------------------------------------------ 2
KCNG1 18 ------------------------------------------ 17
KCNG2 1 ------------------------------------------ 0
KCNG3 5 ------------------------------------------ 4
KCNG4 19 ------------------------------------------ 18
KCNV1 3 ------------------------------------------ 2
KCNV2 23 GSQ-----------------------------HRRSICSLGA 35
KCNS1 3 ------------------------------------------ 2
KCNS2 3 ------------------------------------------ 2
KCNS3 3 ------------------------------------------ 2
cons 43 84
KCNQ1 4 ----AS------------------------------------ 5
KCNQ2 1 ------------------------------------------ 0
KCNQ3 1 ------------------------------------------ 0
KCNQ4 1 ------------------------------------------ 0
KCNQ5 9 E---EG------------------------------------ 11
KCNA1 1 ------------------------------------------ 0
KCNA2 1 ------------------------------------------ 0
KCNA3 43 -----------P------------------------------ 43
KCNA4 60 GSHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAHYRQSS 101
KCNA5 43 SDGPKEPAPKG------------------------------- 53
KCNA6 18 P--------EG------------------------------- 20
KCNA7 2 ------------------------------------------ 1
KCNA10 29 ATDFDSTSPKG------------------------------- 39
KCNB1 2 ------------------------------------------ 1
KCNB2 3 ------------------------------------------ 2
KCNC1 1 ------------------------------------------ 0
KCNC2 1 ------------------------------------------ 0
KCNC3 14 ------------------------------------------ 13
KCNC4 14 ------------------------------------------ 13
KCND1 11 ------------------------------------------ 10
KCND2 11 ------------------------------------------ 10
KCND3 11 ------------------------------------------ 10
KCNF1 3 ------------------------------------------ 2
KCNG1 18 ------------------------------------------ 17
KCNG2 1 ------------------------------------------ 0
KCNG3 5 ------------------------------------------ 4
KCNG4 19 ------------------------------------------ 18
KCNV1 3 ------------------------------------------ 2
KCNV2 36 ---RSGS----------------------------------- 39
KCNS1 3 ------------------------------------------ 2
KCNS2 3 ------------------------------------------ 2
KCNS3 3 ------------------------------------------ 2
cons 85 126
KCNQ1 6 -------------------SPPRAERK--------RWGWGRL 20
KCNQ2 1 --------------------M---------------VQKSRN 7
KCNQ3 1 --------------------MGLKARR--------AAGAAGG 14
KCNQ4 1 --------------------M-------------------AE 3
KCNQ5 12 -------------------GAAGLWVK--------SGAAAAA 26
KCNA1 1 -------------------MTVMSGE---------N------ 8
KCNA2 1 -------------------MTVATGD---------P------ 8
KCNA3 44 ----------AAGRELPPDMTVVPGD---------H------ 60
KCNA4 102 FPHCSDLMPSGSEEKILRELSEEEED---------E------ 128
KCNA5 54 ------RGAQRDADSGVRPLPPLPDP---------G------ 74
KCNA6 21 ------EQQ----D---------------------------- 24
KCNA7 2 --------------------EP-------------R------ 4
KCNA10 40 ------RPGGSSFSNGKIL-ISESTN---------H------ 59
KCNB1 2 ------------------------PA---------G------ 4
KCNB2 3 ---------------------EKAPP---------G------ 8
KCNC1 1 ------------------------------------------ 0
KCNC2 1 ------------------------------------------ 0
KCNC3 14 -----------QGASKQQPAPPPQPPESPPPPPLPP------ 38
KCNC4 14 -----------KSGNKP------------------------- 19
KCND1 11 ---------------------FARAA---------A------ 16
KCND2 11 ---------------------FARAA---------A------ 16
KCND3 11 ---------------------FARAA---------A------ 16
KCNF1 3 ---------------------GSGER---------S------ 8
KCNG1 18 -----------CTSDASFHPAFLPQR---------Q------ 33
KCNG2 1 ------------MEPWP---CSPGGG---------G------ 12
KCNG3 5 ------------------------------------------ 4
KCNG4 19 -----------SHSPWSQLLSSPMET---------P------ 34
KCNV1 3 ---------------------SSGRA---------L------ 8
KCNV2 40 -------------------QASIHGW---------T------ 47
KCNS1 3 ---------------------MLLVR---------G------ 8
KCNS2 3 ---------------------GQSLW---------D------ 8
KCNS3 3 ---------------------FGEFF---------------- 7
cons 127 168
KCNQ1 21 PGARRG------------------------------------ 26
KCNQ2 8 GGVYPG------------------------------------ 13
KCNQ3 15 GGDGGGGGGG-------AA----------------NPAG--- 30
KCNQ4 4 APPRRL------------------------------------ 9
KCNQ5 27 AGGGRL------------------------------------ 32
KCNA1 9 VDEASAAPG---------------HPQ--------------- 20
KCNA2 9 ADEAAALPG---------------HPQ--------------- 20
KCNA3 61 LLEPEVADGG-------GA-----PPQGGC----GGGGCDRY 86
KCNA4 129 EEEEEEEEEG-------RF-----YYSEDD----HGDEC--- 151
KCNA5 75 VRPLPPLPEE-------LP-----RPRRPP----PEDEE--- 97
KCNA6 25 --------AG-------DF-----PEAGG------------- 33
KCNA7 5 CP---------------------------------------- 6
KCNA10 60 ETAFSKLPGD-------YA-----DPPGPE----PVVLN--- 82
KCNB1 5 --------M---------------TKH--------------- 8
KCNB2 9 --------L---------------NRK--------------- 12
KCNC1 1 ------------------------------------------ 0
KCNC2 1 ------------------------------------------ 0
KCNC3 39 QQQQPAQPGP-------AA-----SPAGPPAPRGPGDRR--- 65
KCNC4 20 --------P----------------------------S---- 21
KCND1 17 VGWLPLAQQP-------LP----------------------- 28
KCND2 17 IGWMPVASGP-------MP----------------------- 28
KCND3 17 IGWMPVANCP-------MP----------------------- 28
KCNF1 9 ------------------------------------------ 8
KCNG1 34 AI--K-GAF---------------YRR--------------- 42
KCNG2 13 G----------------------------------------- 13
KCNG3 5 ------------------------------------------ 4
KCNG4 35 SI--K-GLY---------------YRR--------------- 43
KCNV1 9 --------L-----------DSPLDSG--------------- 16
KCNV2 48 EGNYNYYIEEDEDGEEEDQWKDDLAEE--------------- 74
KCNS1 9 --------THYENLRSKVVLPTPLGGR--------------- 27
KCNS2 9 ------------------------------------------ 8
KCNS3 8 ------------------------------------------ 7
cons 169 210
KCNQ1 27 -----S------------------------------------ 27
KCNQ2 14 -------P---SGE-----------K-KLKV-------GFVG 26
KCNQ3 31 ---GDAAA---AGD-----------E-ERKVGLAPGDVEQVT 54
KCNQ4 10 ----GLGP---PPG-----------D-APRA-------E-LV 24
KCNQ5 33 ----GSGM---KDV-----------E-SGRG-------R-VL 47
KCNA1 21 DG-S------YP-R---------Q-A-D---HDDHECCERVV 40
KCNA2 21 DT-Y------DP-----------E--------ADHECCERVV 36
KCNA3 87 EP-L------PP-S---------L-PAA---GEQDCCGERVV 107
KCNA4 152 SY-T------DL-LPQDEGGGG-Y-S-S---VRYSDCCERVV 179
KCNA5 98 EE-G------DP-G--LGTVED-Q-A-L---GTASLHHQRVH 123
KCNA6 34 -------------------------------GGGCCSSERLV 44
KCNA7 7 --------------------------------PPCGCCERLV 16
KCNA10 83 -----------------------------------EGNQRVI 89
KCNB1 9 GS-RSTSSLPPE-P---------M-E-I---VRSKACSRRVR 34
KCNB2 13 TS-RSTLSLPPE-P---------V-D-I---IRSKTCSRRVK 38
KCNC1 1 -------------------------------MGQGDESERIV 11
KCNC2 1 -------------------------------MGKIENNERVI 11
KCNC3 66 AEPC------PG-L---P-A-AAMGR-H---GGGGGDSGKIV 91
KCNC4 22 K----------------T----CLKE-E---MAKGEASEKII 39
KCND1 29 -----------P-A---------P-G-V---KAS-RGDEVLV 43
KCND2 29 -----------A-P---------P-R-Q---ERKRTQDALIV 44
KCND3 29 -----------L-A---------P-A-D---KNK-RQDELIV 43
KCNF1 9 ---------LPE-P---------G-S-Q---SSAASDDIEIV 26
KCNG1 43 A--Q-RLRPQDE-P---------R-Q-G---CQPEDRRRRII 66
KCNG2 14 -----------------------------------TRARHVI 20
KCNG3 5 ----------------------------------RSGAASVV 12
KCNG4 44 V--R-KVGAL-----------------D---ASPVDLKKEIL 62
KCNV1 17 SL-TSLDSSVFC-S---------E-G-E---GEPLALGDCFT 42
KCNV2 75 DQ-QAGEVTTAK-P---------E-G-P---SDPPALLSTLN 100
KCNS1 28 ST-ETFVSEFPG-P---------D-T-G---IRWRRSDEALR 53
KCNS2 9 ---------------------------V---SEANVEDGEIR 20
KCNS3 8 -------------------------------HRPGQDEELVN 18
cons 211 252
KCNQ1 28 ------------------------------------------ 27
KCNQ2 27 LDP--------------------------------------- 29
KCNQ3 55 LAL--------------------------------------- 57
KCNQ4 25 ALT--------------------------------------- 27
KCNQ5 48 LNS--------------------------------------- 50
KCNA1 41 INI--------------------------------------- 43
KCNA2 37 INI--------------------------------------- 39
KCNA3 108 INI--------------------------------------- 110
KCNA4 180 INV--------------------------------------- 182
KCNA5 124 INI--------------------------------------- 126
KCNA6 45 INI--------------------------------------- 47
KCNA7 17 LNV--------------------------------------- 19
KCNA10 90 INI--------------------------------------- 92
KCNB1 35 LNV--------------------------------------- 37
KCNB2 39 INV--------------------------------------- 41
KCNC1 12 INVGGTRHQTYRSTLRTLPGTRLAWLAEPDAH---------- 43
KCNC2 12 LNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDK 53
KCNC3 92 INVGGVRHETYRSTLRTLPGTRLAGLTEPEAA---------- 123
KCNC4 40 INVGGTRHETYRSTLRTLPGTRLAWLADPDGG---------- 71
KCND1 44 VNV--------------------------------------- 46
KCND2 45 LNV--------------------------------------- 47
KCND3 44 LNV--------------------------------------- 46
KCNF1 27 VNV--------------------------------------- 29
KCNG1 67 INV--------------------------------------- 69
KCNG2 21 INV--------------------------------------- 23
KCNG3 13 LNV--------------------------------------- 15
KCNG4 63 INV--------------------------------------- 65
KCNV1 43 VNV--------------------------------------- 45
KCNV2 101 VNV--------------------------------------- 103
KCNS1 54 VNV--------------------------------------- 56
KCNS2 21 INV--------------------------------------- 23
KCNS3 19 LNV--------------------------------------- 21
cons 253 294
KCNQ1 28 ---A--GLAKKCPFSLELAE---------GG---------P- 45
KCNQ2 30 ---GAPDSTRDGALLIA------------GS---------E- 46
KCNQ3 58 ---G-AGADKDGTLLLEG-----------GG---------R- 74
KCNQ4 28 ---AV--QSEQGEAGGG------------GS---------P- 42
KCNQ5 51 ---AA--ARGDGLLLLGTRAATL------GG---------G- 71
KCNA1 44 ---SG--LRFETQLKTLAQFPNTLL----GN-PK-------- 67
KCNA2 40 ---SG--LRFETQLKTLAQFPETLL----GD-PK-------- 63
KCNA3 111 ---SG--LRFETQLKTLCQFPETLL----GD-PK-------- 134
KCNA4 183 ---SG--LRFETQMKTLAQFPETLL----GD-PE-------- 206
KCNA5 127 ---SG--LRFETQLGTLAQFPNTLL----GD-PA-------- 150
KCNA6 48 ---SG--LRFETQLRTLSLFPDTLL----GD-PG-------- 71
KCNA7 20 ---AG--LRFETRARTLGRFPDTLL----GD-PA-------- 43
KCNA10 93 ---AG--LRFETQLRTLSQFPETLL----GD-RE-------- 116
KCNB1 38 ---GG--LAHEVLWRTLDRLPRTRL----GK-LRDCNT--HD 67
KCNB2 42 ---GG--LNHEVLWRTLDRLPRTRL----GK-LRDCNT--HE 71
KCNC1 44 ----------------------S------------------- 44
KCNC2 54 LQPSPPPLSPPPRAPPLSPGPGGCFEGGAGNCSS-------- 87
KCNC3 124 ----------------------ARF----------------- 126
KCNC4 72 ----------------------GRPETDGGGV---------- 81
KCND1 47 ---SG--RRFETWKNTLDRYPDTLL----GS-SE-------- 70
KCND2 48 ---SG--TRFQTWQDTLERYPDTLL----GS-SE-------- 71
KCND3 47 ---SG--RRFQTWRTTLERYPDTLL----GS-TE-------- 70
KCNF1 30 ---GG--VRQVLYGDLLSQYPETRL----AE-LINCLAGGYD 61
KCNG1 70 ---GG--IKYSLPWTTLDEFPLTRL----GQ-LKACTN--FD 99
KCNG2 24 ---GG--CRVRLAWAALARCPLARL----ER-LRACRG--HD 53
KCNG3 16 ---GG--ARYSLSRELLKDFPLRRV----SR-LHGCRS--ER 45
KCNG4 66 ---GG--RRYLLPWSTLDRFPLSRL----SK-LRLCRS--YE 95
KCNV1 46 ---GG--SRFVLSQQALSCFPHTRL----GK-LAVVVA--SY 75
KCNV2 104 ---GG--HSYQLDYCELAGFPKTRL----GR-LATSTS--RS 133
KCNS1 57 ---GG--VRRQLSARALARFPGTRL----GR-LQAAAS--EE 86
KCNS2 24 ---GG--FKRRLRSHTLLRFPETRL----GR-LLLCHS--RE 53
KCNS3 22 ---GG--FKQSVDQSTLLRFPHTRL----GK-LLTCHS--EE 51
cons 295 336
KCNQ1 46 -----------------------AGGALYAPIAPGAPGP--- 61
KCNQ2 47 ---------------------------------APK------ 49
KCNQ3 75 ------------------------DEGQR------------- 79
KCNQ4 43 ------------------------------R-RLGL------ 47
KCNQ5 72 ------------------------GGGLRES-RRG------- 81
KCNA1 68 ----------KR--MR---YFDPLRNEYFFDRNRPSFDAILY 94
KCNA2 64 ----------KR--MR---YFDPLRNEYFFDRNRPSFDAILY 90
KCNA3 135 ----------RR--MR---YFDPLRNEYFFDRNRPSFDAILY 161
KCNA4 207 ----------KR--TQ---YFDPLRNEYFFDRNRPSFDAILY 233
KCNA5 151 ----------KR--LR---YFDPLRNEYFFDRNRPSFDGILY 177
KCNA6 72 ----------RR--VR---FFDPLRNEYFFDRNRPSFDAILY 98
KCNA7 44 ----------RR--GR---FYDDARREYFFDRHRPSFDAVLY 70
KCNA10 117 ----------KR--MQ---FFDSMRNEYFFDRNRPSFDGILY 143
KCNB1 68 ----------SL--LEVCDDYSLDDNEYFFDRHPGAFTSILN 97
KCNB2 72 ----------SL--LEVCDDYNLNENEYFFDRHPGAFTSILN 101
KCNC1 45 --------------HF---DYDPRADEFFFDRHPGVFAHILN 69
KCNC2 88 ----------RGGRAS---DHPGGGREFFFDRHPGVFAYVLN 116
KCNC3 127 -------------------DYDPGADEFFFDRHPGVFAYVLN 149
KCNC4 82 ------------GSSG---SSGGGGCEFFFDRHPGVFAYVLN 108
KCND1 71 ----------KE---F---FYDADSGEYFFDRDPDMFRHVLN 96
KCND2 72 ----------RD---F---FYHPETQQYFFDRDPDIFRHILN 97
KCND3 71 ----------KE---F---FFNEDTKEYFFDRDPEVFRCVLN 96
KCNF1 62 ----------TI--FSLCDDYDPGKREFYFDRDPDAFKCVIE 91
KCNG1 100 ----------DI--LNVCDDYDVTCNEFFFDRNPGAFGTILT 129
KCNG2 54 ----------DL--LRVCDDYDVSRDEFFFDRSPCAFRAIVA 83
KCNG3 46 ----------DV--LEVCDDYDRERNEYFFDRHSEAFGFILL 75
KCNG4 96 ----------EI--VQLCDDYDEDSQEFFFDRSPSAFGVIVS 125
KCNV1 76 RRPGALAAVPSP--LELCDDANPVDNEYFFDRSSQAFRYVLH 115
KCNV2 134 ----------RQ--LSLCDDYEEQTDEYFFDRDPAVFQLVYN 163
KCNS1 87 ----------QA--RRLCDDYDEAAREFYFDRHPGFFLSLLH 116
KCNS2 54 ----------AI--LELCDDYDDVQREFYFDRNPELFPYVLH 83
KCNS3 52 ----------AI--LELCDDYSVADKEYYFDRNPSLFRYVLN 81
cons 337 378
KCNQ1 62 -----APPASP-----AAPAAPPVASDL-G--PRP--PVSL- 87
KCNQ2 50 ----------R-----GSILS--------K--PRA--GGA-- 62
KCNQ3 80 ----------------R-TPQ--------G--IGLLAKT--- 91
KCNQ4 48 ----------LGSPLPPGAPLP-------G--PGS--GSGS- 67
KCNQ5 82 ---------------KQGARMS-------L--LGK--PL-SY 96
KCNA1 95 YYQSGGRLRRPV-----NVPLDMFSEEIKFYELGE--EAME- 128
KCNA2 91 YYQSGGRLRRPV-----NVPLDIFSEEIRFYELGE--EAME- 124
KCNA3 162 YYQSGGRIRRPV-----NVPIDIFSEEIRFYQLGE--EAME- 195
KCNA4 234 YYQSGGRLKRPV-----NVPFDIFTEEVKFYQLGE--EALL- 267
KCNA5 178 YYQSGGRLRRPV-----NVSLDVFADEIRFYQLGD--EAME- 211
KCNA6 99 YYQSGGRLRRPV-----NVPLDIFLEEIRFYQLGD--EALA- 132
KCNA7 71 YYQSGGRLRRPA-----HVPLDVFLEEVAFYGLGA--AALA- 104
KCNA10 144 YYQSGGKIRRPA-----NVPIDIFADEISFYELGS--EAMD- 177
KCNB1 98 FYRT-GRLHMME-----EMCALSFSQELDYWGIDE--IYLE- 130
KCNB2 102 FYRT-GKLHMME-----EMCALSFGQELDYWGIDE--IYLE- 134
KCNC1 70 YYRT-GKLHCPA-----DVCGPLYEEELAFWGIDE--TDVE- 102
KCNC2 117 YYRT-GKLHCPA-----DVCGPLFEEELAFWGIDE--TDVE- 149
KCNC3 150 YYRT-GKLHCPA-----DVCGPLFEEELGFWGIDE--TDVE- 182
KCNC4 109 YYRT-GKLHCPA-----DVCGPLFEEELTFWGIDE--TDVE- 141
KCND1 97 FYRT-GRLHCPR-----QECIQAFDEELAFYGLVP--ELVG- 129
KCND2 98 FYRT-GKLHYPR-----HECISAYDEELAFFGLIP--EIIG- 130
KCND3 97 FYRT-GKLHYPR-----YECISAYDDELAFYGILP--EIIG- 129
KCNF1 92 VYYF-GEVHMKK-----GICPICFKNEMDFWKVDL--KFLD- 124
KCNG1 130 FLRA-GKLRLLR-----EMCALSFQEELLYWGIAE--DHLD- 162
KCNG2 84 LLRA-GKLRLLR-----GPCALAFRDELAYWGIDE--ARLE- 116
KCNG3 76 YVRGHGKLRFAP-----RMCELSFYNEMIYWGLEG--AHLE- 109
KCNG4 126 FLAA-GKLVLLQ-----EMCALSFQEELAYWGIEE--AHLE- 158
KCNV1 116 YYRT-GRLHVME-----QLCALSFLQEIQYWGIDE--LSID- 148
KCNV2 164 FYLS-GVLLVLD-----GLCPRRFLEELGYWGVRL--KYTP- 196
KCNS1 117 FYRT-GHLHVLD-----ELCVFAFGQEADYWGLGE--NALA- 149
KCNS2 84 FYHT-GKLHVMA-----ELCVFSFSQEIEYWGINE--FFID- 116
KCNS3 82 FYYT-GKLHVME-----ELCVFSFCQEIEYWGINE--LFID- 114
cons 379 420
KCNQ1 88 -----DPRVSIYSTRRPVLARTH------------------- 105
KCNQ2 63 GAGK-PPKRNAFYRK--------------------------- 76
KCNQ3 92 PLSRPVKRNNAKYRR--------------------------- 106
KCNQ4 68 ACGQRSSAAHKRYRR--------------------------- 82
KCNQ5 97 TSSQ-SCRRNVKYRR--------------------------- 110
KCNA1 129 ---K--FREDEGF----------------------------- 136
KCNA2 125 ---M--FREDEGY----------------------------- 132
KCNA3 196 ---K--FREDEGF----------------------------- 203
KCNA4 268 ---K--FREDEGF----------------------------- 275
KCNA5 212 ---R--FREDEGF----------------------------- 219
KCNA6 133 ---A--FREDEGC----------------------------- 140
KCNA7 105 ---R--LREDEGC----------------------------- 112
KCNA10 178 ---Q--FREDEGF----------------------------- 185
KCNB1 131 ---S--CCQARYHQKKEQMNEELKREAE-T------------ 154
KCNB2 135 ---S--CCQARYHQKKEQMNEELRREAE-T------------ 158
KCNC1 103 ---P--CCWMTYRQHRDAEEALDSFGGAP-LDNSADDADADG 138
KCNC2 150 ---P--CCWMTYRQHRDAEEALDIFETPD-LI---------- 175
KCNC3 183 ---A--CCWMTYRQHRDAEEALDSFEAPD-PAGAANAANAAG 218
KCNC4 142 ---P--CCWMTYRQHRDAEEALDIFESPD-G-----GGSGAG 172
KCND1 130 ---D--CCLEEYRDRKKENAERLAEDEEA-E----------- 154
KCND2 131 ---D--CCYEEYKDRRRENAERLQDDADT-D----------- 155
KCND3 130 ---D--CCYEEYKDRKRENAERLMDDNDS-E----------- 154
KCNF1 125 ---D--CCKSHLSEKREELEEIARRVQL-------------- 147
KCNG1 163 ---G--CCKRRYLQKIEEFAEMVEREEEDDA----------- 188
KCNG2 117 ---R--CCLRRLRRREEEAAEARAGPTER------------- 140
KCNG3 110 ---Y--CCQRRLDDRMSDTYTFYSADEPG------------- 133
KCNG4 159 ---R--CCLRKLLRKLEELEELAKLHREDVL----------- 184
KCNV1 149 ---S--CCRDRYFRRKE-LSETLDFKKD-T------------ 171
KCNV2 197 ---R--CCRICFEERRDELSERLKIQHE-------------- 219
KCNS1 150 ---A--CCRARYLERRLTQ-PHAWDEDSDTP------SSVD- 178
KCNS2 117 ---S--CCSYSYHGRKVEPEQEKWDEQSDQE-------STT- 145
KCNS3 115 ---S--CCSNRYQERKEENHEKDWDQKSHDV-------STD- 143
cons 421 462
KCNQ1 106 ------------------------------------------ 105
KCNQ2 77 ------------------------------------------ 76
KCNQ3 107 ------------------------------------------ 106
KCNQ4 83 ------------------------------------------ 82
KCNQ5 111 ------------------------------------------ 110
KCNA1 137 ----------I---K---EE-E-R-----PL----------- 144
KCNA2 133 ----------I---K---EE-E-R-----PL----------- 140
KCNA3 204 ----------L---R---EE-E-R-----PL----------- 211
KCNA4 276 ----------V---RE--EE-D-R-----AL----------- 284
KCNA5 220 ----------I---K---EE-E-K-----PL----------- 227
KCNA6 141 ----------L---PEGGED-E-K-----PL----------- 151
KCNA7 113 ----------P---V---PP-E-R-----PL----------- 120
KCNA10 186 ----------I---K---DP-E-T-----LL----------- 193
KCNB1 155 ----------------LRER-E-G-----EE----------- 162
KCNB2 159 ----------------MRER-E-G-----EE----------- 166
KCNC1 139 PGDS-GDG-----------EDE-L----EMTKRLALSDS--- 160
KCNC2 176 GGDP-GDD------------ED-L-----AAKRLGIEDAAG- 197
KCNC3 219 AHDGGLDDEAG---A---GGGG-LDGAGGELKRLCFQDAGGG 253
KCNC4 173 PSDEAGDD-----------ERE-L-----ALQRLGPHEGG-- 195
KCND1 155 --------------Q---AG-DGP-----AL----------- 162
KCND2 156 --------------T---AG-ES------AL----------- 162
KCND3 155 --------------N---NQ--E------SM----------- 160
KCNF1 148 ----------------ILDD-L-G-----VD----------- 155
KCNG1 189 ----------LDSEG-RDSE-G-------PA----------- 200
KCNG2 141 ------------GAQ-GSPA-R-------AL----------- 150
KCNG3 134 ------------VLG-RDEA-R-------PG----------- 143
KCNG4 185 ------------RQQ-RETR-R-------PA----------- 194
KCNV1 172 ----------EDQES-QHES---E-----QD----------- 183
KCNV2 220 -------L--RAQA--QVEE-A-E-----EL----------- 232
KCNS1 179 ---PC-PD--E-IS--DVQR-E-L-----AR----------- 193
KCNS2 146 ---SS-FD--E-IL--AFYN-D-A-----SK----------- 160
KCNS3 144 ---SS-FE--E-SS--LFEK-E-L-----EK----------- 158
cons 463 504
KCNQ1 106 --------------------VQGRVYNFLERPT-GWKCFVYH 126
KCNQ2 77 --------------------LQNFLYNVLERPR-G-WAFIYH 96
KCNQ3 107 --------------------IQTLIYDALERPR-G-WALLYH 126
KCNQ4 83 --------------------LQNWVYNVLERPR-G-WAFVYH 102
KCNQ5 111 --------------------VQNYLYNVLERPR-G-WAFIYH 130
KCNA1 145 --------------P-EK-EYQRQVWLLFEYPESSGPARVIA 170
KCNA2 141 --------------P-EN-EFQRQVWLLFEYPESSGPARIIA 166
KCNA3 212 --------------P-RR-DFQRQVWLLFEYPESSGPARGIA 237
KCNA4 285 --------------P-EN-EFKKQIWLLFEYPESSSPARGIA 310
KCNA5 228 --------------P-RN-EFQRQVWLIFEYPESSGSARAIA 253
KCNA6 152 --------------P-SQ-PFQRQVWLLFEYPESSGPARGIA 177
KCNA7 121 --------------P-RR-AFARQLWLLFEFPESSQAARVLA 146
KCNA10 194 --------------P-TN-DIHRQFWLLFEYPESSSAARAVA 219
KCNB1 163 -----F----DNT-C-CA-EKRKKLWDLLEKPNSSVAAKILA 192
KCNB2 167 -----F----DNT-C-CP-DKRKKLWDLLEKPNSSVAAKILA 196
KCNC1 161 ---PDG----RPGGF-WR-RWQPRIWALFEDPYSSRYARYVA 193
KCNC2 198 LGGPDG----KSGR--WR-RLQPRMWALFEDPYSSRAARFIA 232
KCNC3 254 AGGPPGGAGGAGGTW-WR-RWQPRVWALFEDPYSSRAARYVA 293
KCNC4 196 -AGHGA----GSGG--CR-GWQPRMWALFEDPYSSRAARVVA 229
KCND1 163 --------------PAGS-SLRQRLWRAFENPHTSTAALVFY 189
KCND2 163 --------------PTMT--ARQRVWRAFENPHTSTMALVFY 188
KCND3 161 --------------PSLS--FRQTMWRAFENPHTSTLALVFY 186
KCNF1 156 -----A----AEG-R-WR-RCQKCVWKFLEKPESSCPARVVA 185
KCNG1 201 -----E----GEGRL-GR--CMRRLRDMVERPHSGLPGKVFA 230
KCNG2 151 -----G----PRGRL-QR--GRRRLRDVVDNPHSGLAGKLFA 180
KCNG3 144 -----G----AEAAP-SR-RWLERMRRTFEEPTSSLAAQILA 174
KCNG4 195 -----S----HSSRW-GL--CMNRLREMVENPQSGLPGKVFA 224
KCNV1 184 -----F----SQG-P-CP-TVRQKLWNILEKPGSSTAARIFG 213
KCNV2 233 -----F----RDM-R-FYGPQRRRLWNLMEKPFSSVAAKAIG 263
KCNS1 194 -----Y----GAA-R-CG-RLRRRLWLTMENPGYSLPSKLFS 223
KCNS2 161 -----F----DGQ-P-LG-NFRRQLWLALDNPGYSVLSRVFS 190
KCNS3 159 -----F----DTL-R-FG-QLRKKIWIRMENPAYCLSAKLIA 188
cons 505 . .: * 546
KCNQ1 127 FAVFLIVLVCLIFSVLSTIEQYA------------------- 149
KCNQ2 97 AYVFLLVFSCLVLSVFSTIKEYE------------------- 119
KCNQ3 127 ALVFLIVLGCLILAVLTTFKEYE------------------- 149
KCNQ4 103 VFIFLLVFSCLVLSVLSTIQEHQ------------------- 125
KCNQ5 131 AFVFLLVFGCLILSVFSTIPEHT------------------- 153
KCNA1 171 IVSVMVILISIVIFCLETLPELKDDK-DF--------TG--- 200
KCNA2 167 IVSVMVILISIVSFCLETLPIFRDEN-ED--------MHGSG 199
KCNA3 238 IVSVLVILISIVIFCLETLPEFRDEK-DY--------PA-ST 269
KCNA4 311 IVSVLVILISIVIFCLETLPEFRDDR-DL--------VM-AL 342
KCNA5 254 IVSVLVILISIITFCLETLPEFRDER-ELLRHPPAP------ 288
KCNA6 178 IVSVLVILISIVIFCLETLPQFRVDG-RGGNNGGVSRVS-PV 217
KCNA7 147 VVSVLVILVSIVVFCLETLPDFRDDR-DGTGL-----AA-AA 181
KCNA10 220 VVSVLVVVISITIFCLETLPEFREDR-EL--------KV--- 249
KCNB1 193 IISIMFIVLSTIALSLNTLPELQSLD-EF--------GQ--- 222
KCNB2 197 IVSILFIVLSTIALSLNTLPELQETD-EF--------GQ--- 226
KCNC1 194 FASLFFILVSITTFCLETHERFNPIV-NK--------TE-I- 224
KCNC2 233 FASLFFILVSITTFCLETHEAFNI---VK--------NK-T- 261
KCNC3 294 FASLFFILISITTFCLETHEGFIHIS-NK--------TV-T- 324
KCNC4 230 FASLFFILVSITTFCLETHEAFNI---DR-NV-----TE-I- 260
KCND1 190 YVTGFFIAVSVIANVVETIPCRGSAR-RS--------SR--- 219
KCND2 189 YVTGFFIAVSVIANVVETVPCGS-SP-GH--------IK--- 217
KCND3 187 YVTGFFIAVSVITNVVETVPCGT-VP-G---------SK--- 214
KCNF1 186 VLSFLLILVSSVVMCMGTIPELQVLD-AE--------GN--- 215
KCNG1 231 CLSVLFVTVTAVNLSVSTLPSLREEEE-Q--------GH--- 260
KCNG2 181 CVSVSFVAVTAVGLCLSTMPDIRAEEE-R--------GE--- 210
KCNG3 175 SVSVVFVIVSMVVLCASTLPDWR-NAAAD--------NR--- 204
KCNG4 225 CLSILFVATTAVSLCVSTMPDLRAEED-Q--------GE--- 254
KCNV1 214 VISIIFVVVSIINMALMSAELS-------------------- 235
KCNV2 264 VASSTFVLVSVVALALNTVEEMQQHS-GQ--------GE--- 293
KCNS1 224 CVSISVVLASIAAMCIHSLPEYQARE-AA--------AA--- 253
KCNS2 191 ILSILVVMGSIITMCLNSLPDFQIPD-SQ--------GN--- 220
KCNS3 189 ISSLSVVLASIVAMCVHSMSEFQNED-GE------------- 216
cons 547 .: : 588
KCNQ1 150 ---------------------------------------ALA 152
KCNQ2 120 ---------------------------------------KSS 122
KCNQ3 150 ---------------------------------------TVS 152
KCNQ4 126 ---------------------------------------ELA 128
KCNQ5 154 ---------------------------------------KLA 156
KCNA1 201 --------------TV-HRI----D------NTTVIYNSNIF 217
KCNA2 200 ---V----------TF-HTY----S-----NSTIGYQQSTSF 218
KCNA3 270 ---SQD--------SF-EAAG---N-----STSGSRAGASSF 291
KCNA4 343 ---SAG--------GH-GGLLNDTS-----APHLENSGHTIF 367
KCNA5 289 ---HQPPAPAPGAN--GSGVMAPPS-----GPTVAPLLPRTL 320
KCNA6 218 SRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFF 259
KCNA7 182 ---AAG--------PF-PAPL-NGS-----SQMPGNPPRLPF 205
KCNA10 250 --------------VR-DPN----L-----NMSKTVLSQTMF 267
KCNB1 223 ----------------------------------------ST 224
KCNB2 227 ----------------------------------------LN 228
KCNC1 225 ---E-------------NV-----R-----NGTQVRYYREAE 240
KCNC2 262 ---E-------------PV-----I-----NGTSVVLQYEIE 277
KCNC3 325 ---QA---------SP-IP-----G-----APPENITNVEVE 343
KCNC4 261 ---L-------------RV-----G-----NITSVHFRREVE 276
KCND1 220 ----------------------------------EQPCGERF 227
KCND2 218 ----------------------------------ELPCGERY 225
KCND3 215 ----------------------------------ELPCGERY 222
KCNF1 216 ----------------------------------------RV 217
KCNG1 261 ------------------C--------------------SQM 264
KCNG2 211 ------------------C--------------------SPK 214
KCNG3 205 ------------------S-L----------DDRSRYSAGPG 217
KCNG4 255 ------------------C--------------------SRK 258
KCNV1 236 ----------------------------------------WL 237
KCNV2 294 ------------------G--------------------GPD 297
KCNS1 254 ------------------VA----------AVAAGRSPEGVR 267
KCNS2 221 ----------------------------------------PG 222
KCNS3 217 -----------------------------------------V 217
cons 589 630
KCNQ1 153 TGT-LF-WMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLR 192
KCNQ2 123 EGA-LY-ILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLK 162
KCNQ3 153 GDW-LL-LLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLK 192
KCNQ4 129 NEC-LL-ILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFR 168
KCNQ5 157 SSC-LL-ILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLR 196
KCNA1 218 TDP-FF-IVETLCIIWFSFELVVR---------FFACPSKTD 248
KCNA2 219 TDP-FF-IVETLCIIWFSFEFLVR---------FFACPSKAG 249
KCNA3 292 SDP-FF-VVETLCIIWFSFELLVR---------FFACPSKAT 322
KCNA4 368 NDP-FF-IVETVCIVWFSFEFVVR---------CFACPSQAL 398
KCNA5 321 ADP-FF-IVETTCVIWFTFELLVR---------FFACPSKAG 351
KCNA6 260 TDP-FF-LVETLCIVWFTFELLVR---------FSACPSKPA 290
KCNA7 206 NDP-FF-VVETLCICWFSFELLVR---------LLVCPSKAI 236
KCNA10 268 TDP-FF-MVESTCIVWFTFELVLR---------FVVCPSKTD 298
KCNB1 225 DNPQLA-HVEAVCIAWFTMEYLLR---------FLSSPKKWK 256
KCNB2 229 DNRQLA-HVEAVCIAWFTMEYLLR---------FLSSPNKWK 260
KCNC1 241 TEA-FLTYIEGVCVVWFTFEFLMR---------VIFCPNKVE 272
KCNC2 278 TDP-ALTYVEGVCVVWFTFEFLVR---------IVFSPNKLE 309
KCNC3 344 TEP-FLTYVEGVCVVWFTFEFLMR---------ITFCPDKVE 375
KCNC4 277 TEP-ILTYIEGVCVLWFTLEFLVR---------IVCCPDTLD 308
KCND1 228 PQA-FF-CMDTACVLIFTGEYLLR---------LFAAPSRCR 258
KCND2 226 AVA-FF-CLDTACVMIFTVEYLLR---------LAAAPSRYR 256
KCND3 223 SVA-FF-CLDTACVMIFTVEYLLR---------LFAAPSRYR 253
KCNF1 218 EHPTLE-NVETACIGWFTLEYLLR---------LFSSPNKLH 249
KCNG1 265 CHN-VF-IVESVCVGWFSLEFLLR---------LIQAPSKFA 295
KCNG2 215 CRS-LF-VLETVCVAWFSFEFLLR---------SLQAESKCA 245
KCNG3 218 REP-SG-IIEAICIGWFTAECIVR---------FIVSKNKCE 248
KCNG4 259 CYY-IF-IVETICVAWFSLEFCLR---------FVQAQDKCQ 289
KCNV1 238 DLQLLE-ILEYVCISWFTGEFVLR---------FLCVRDRCR 269
KCNV2 298 LRPILE-HVEMLCMGFFTLEYLLR---------LASTPDLRR 329
KCNS1 268 DDPVLR-RLEYFCIAWFSFEVSSR---------LLLAPSTRN 299
KCNS2 223 EDPRFE-IVEHFGIAWFTFELVAR---------FAVAPDFLK 254
KCNS3 218 DDPVLE-GVEIACIAWFTGELAVR---------LAAAPCQKK 249
cons 631 :: : * * * 672
KCNQ1 193 FARKPISIIDLIVVVASMVVLCVG----------------SK 218
KCNQ2 163 FARKPFCVIDIMVLIASIAVLAAG----------------SQ 188
KCNQ3 193 FARKPLCMLDIFVLIASVPVVAVG----------------NQ 218
KCNQ4 169 FARKPFCVIDFIVFVASVAVIAAG----------------TQ 194
KCNQ5 197 FARKPFCVIDTIVLIASIAVVSAK----------------TQ 222
KCNA1 249 FFKNIMNFIDIVAIIPYFITLGTEIAEQEG-------N-QKG 282
KCNA2 250 FFTNIMNIIDIVAIIPYFITLGTELAEKPE-------DAQQG 284
KCNA3 323 FSRNIMNLIDIVAIIPYFITLGTELAERQ----------GNG 354
KCNA4 399 FFKNIMNIIDIVSILPYFITLGTDLAQQQGG------GNGQQ 434
KCNA5 352 FSRNIMNIIDVVAIFPYFITLGTELAEQQ---PGGGGGGQNG 390
KCNA6 291 FFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNG 332
KCNA7 237 FFKNVMNLIDFVAILPYFVALGTELARQR----------GVG 268
KCNA10 299 FFRNIMNIIDIISIIPYFATLITELVQETEP---------SA 331
KCNB1 257 FFKGPLNAIDLLAILPYYVTIFLTES---N--------KSVL 287
KCNB2 261 FFKGPLNVIDLLAILPYYVTIFLTES---N--------KSVL 291
KCNC1 273 FIKNSLNIIDFVAILPFYLEVGLSG-------------LSSK 301
KCNC2 310 FIKNLLNIIDFVAILPFYLEVGLSG-------------LSSK 338
KCNC3 376 FLKSSLNIIDCVAILPFYLEVGLSG-------------LSSK 404
KCNC4 309 FVKNLLNIIDFVAILPFYLEVGLSG-------------LSSK 337
KCND1 259 FLRSVMSLIDVVAILPYYIGLLVPK----------------- 283
KCND2 257 FVRSVMSIIDVVAILPYYIGLVMTD----------------- 281
KCND3 254 FIRSVMSIIDVVAIMPYYIGLVMTN----------------- 278
KCNF1 250 FALSFMNIVDVLAILPFYVSLTLTHL-----------GARMM 280
KCNG1 296 FLRSPLTLIDLVAILPYYITLLVDGAAAGRR----KPGAGNS 333
KCNG2 246 FLRAPLNIIDILALLPFYVSLLLGL-----A----AGPGGTK 278
KCNG3 249 FVKRPLNIIDLLAITPYYISVLMTV-----------FTGENS 279
KCNG4 290 FFQGPLNIIDILAISPYYVSLAVSEEPPEDG----ERPSGSS 327
KCNV1 270 FLRKVPNIIDLLAILPFYITLLVESLSG-S--------QTTQ 302
KCNV2 330 FARSALNLVDLVAILPLYLQLLLECFTGEGH----QRGQTVG 367
KCNS1 300 FFCHPLNLIDIVSVLPFYLTLLAGVALG-D--------QGGK 332
KCNS2 255 FFKNALNLIDLMSIVPFYITLVVNLV---V--------ESTP 285
KCNS3 250 FWKNPLNIIDFVSIIPFYATLAVDTK---E--------EESE 280
cons 673 * :* . . . : 714
KCNQ1 219 GQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQ 260
KCNQ2 189 GNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSK 230
KCNQ3 219 GNVLA-TSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSK 259
KCNQ4 195 GNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSK 236
KCNQ5 223 GNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSK 264
KCNA1 283 EQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMR 324
KCNA2 285 QQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMR 326
KCNA3 355 QQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMR 396
KCNA4 435 QQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMR 476
KCNA5 391 QQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMR 432
KCNA6 333 QQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMR 374
KCNA7 269 QQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMR 310
KCNA10 332 QQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMR 373
KCNB1 288 QFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYN 329
KCNB2 292 QFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYN 333
KCNC1 302 AAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTN 343
KCNC2 339 AAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTN 380
KCNC3 405 AAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTN 446
KCNC4 338 AARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTN 379
KCND1 284 -NDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCAS 324
KCND2 282 -NEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCAS 322
KCND3 279 -NEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCAS 319
KCNF1 281 ELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFK 322
KCNG1 334 YLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTR 375
KCNG2 279 LLERAGLVLRLLRALRVLYVMRLARHSLGLRSLGLTMRRCAR 320
KCNG3 280 QLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYR 321
KCNG4 328 YLEKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTVRRCTR 369
KCNV1 303 ELENVGRIVQVLRLLRALRMLKLGRHSTGLRSLGMTITQCYE 344
KCNV2 368 SVGKVGQVLRVMRLMRIFRILKLARHSTGLRAFGFTLRQCYQ 409
KCNS1 333 EFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYR 374
KCNS2 286 TLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYK 327
KCNS3 281 DIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYH 322
cons 715 .* .: :.:. *: : : . 756
KCNQ1 261 ELITTLYIGFLGLIFSSYFVYLAEKDAVN-----ESGRVEFG 297
KCNQ2 231 ELVTAWYIGFLCLILASFLVYLAEKGE----------NDHFD 262
KCNQ3 260 ELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEFE 301
KCNQ4 237 ELITAWYIGFLVLIFASFLVYLAEKDA----------NSDFS 268
KCNQ5 265 ELITAWYIGFLVLIFSSFLVYLVEKDA----------NKEFS 296
KCNA1 325 ELGLLIFFLFIGVILFSSAVYFAEAEE---------AESHFS 357
KCNA2 327 ELGLLIFFLFIGVILFSSAVYFAEADE---------RESQFP 359
KCNA3 397 ELGLLIFFLFIGVILFSSAVYFAEADD---------PTSGFS 429
KCNA4 477 ELGLLIFFLFIGVILFSSAVYFAEADE---------PTTHFQ 509
KCNA5 433 ELGLLIFFLFIGVILFSSAVYFAEADN---------QGTHFS 465
KCNA6 375 ELGLLIFFLFIGVILFSSAVYFAEADD---------DDSLFP 407
KCNA7 311 ELGLLIFFLFIGVVLFSSAVYFAEVDR---------VDSHFT 343
KCNA10 374 ELGLLIFFLFIGVILFSSAVYFAEVDE---------PESHFS 406
KCNB1 330 ELGLLILFLAMGIMIFSSLVFFAEKDE---------DDTKFK 362
KCNB2 334 ELGLLILFLAMGIMIFSSLVFFAEKDE---------DATKFT 366
KCNC1 344 EFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFK 385
KCNC2 381 EFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFK 422
KCNC3 447 EFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFK 488
KCNC4 380 EFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFK 421
KCND1 325 ELGFLLFSLTMAIIIFATVMFYAEKGT---------NKTNFT 357
KCND2 323 ELGFLLFSLTMAIIIFATVMFYAEKGS---------SASKFT 355
KCND3 320 ELGFLLFSLTMAIIIFATVMFYAEKGS---------SASKFT 352
KCNF1 323 ELGLLLMYLAVGIFVFSALGYTMEQSH---------PETLFK 355
KCNG1 376 EFGLLLLFLCVAIALFAPLLYVIENEM-----A---DSPEFT 409
KCNG2 321 EFGLLLLFLCVAMALFAPLVHLAEREL-----G---ARRDFS 354
KCNG3 322 EMVMLLVFICVAMAIFSALSQLLEHGL-----DLETSNKDFT 358
KCNG4 370 EFGLLLLFLAVAITLFSPLVYVAEKES-----G---RVLEFT 403
KCNV1 345 EVGLLLLFLSVGISIFSTVEYFAEQSI---------PDTTFT 377
KCNV2 410 QVGCLLLFIAMGIFTFSAAVYSVEHDV---------PSTNFT 442
KCNS1 375 EVGILLLYLAVGVSVFSGVAYTAEKEE----------DVGFN 406
KCNS2 328 EVGLLLLYLSVGISIFSVVAYTIEKEE----------NEGLA 359
KCNS3 323 EVGLLLLFLSVGISIFSVLIYSVEKDD---------HTSSLT 355
cons 757 :. : : : * : 798
KCNQ1 298 SYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISF 339
KCNQ2 263 TYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSF 304
KCNQ3 302 TYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSF 343
KCNQ4 269 SYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISF 310
KCNQ5 297 TYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISF 338
KCNA1 358 SIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLT 399
KCNA2 360 SIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLT 401
KCNA3 430 SIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLT 471
KCNA4 510 SIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLT 551
KCNA5 466 SIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLT 507
KCNA6 408 SIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLT 449
KCNA7 344 SIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLT 385
KCNA10 407 SIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLT 448
KCNB1 363 SIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV 404
KCNB2 367 SIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV 408
KCNC1 386 NIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLT 427
KCNC2 423 NIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLT 464
KCNC3 489 NIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLT 530
KCNC4 422 NIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLT 463
KCND1 358 SIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLV 399
KCND2 356 SIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLV 397
KCND3 353 SIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLV 394
KCNF1 356 SIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIA 397
KCNG1 410 SIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILL 451
KCNG2 355 SVPASYWWAVISMTTVGYGDMVPRSLPGQVVALSSILSGILL 396
KCNG3 359 SIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVL 400
KCNG4 404 SIPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILI 445
KCNV1 378 SVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILV 419
KCNV2 443 TIPHSWWWAAVSISTVGYGDMYPETHLGRFFAFLCIAFGIIL 484
KCNS1 407 TIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILV 448
KCNS2 360 TIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILV 401
KCNS3 356 SIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILV 397
cons 799 . . *: :::*:**** * : * . .: 840
KCNQ1 340 FALPAGILGSGFALKVQQKQRQKHFNRQIPA--AAS-LI-QT 377
KCNQ2 305 FALPAGILGSGFALKVQEQHRQKHFEKRRNP--AAG-LI-QS 342
KCNQ3 344 FALPAGILGSGLALKVQEQHRQKHFEKRRKP--AAE-LI-QA 381
KCNQ4 311 FALPAGILGSGFALKVQEQHRQKHFEKRRMP--AAN-LI-QA 348
KCNQ5 339 FALPAGILGSGFALKVQEQHRQKHFEKRRNP--AAN-LI-QC 376
KCNA1 400 IALPVPVIVSNFNYFYHRETEGEEQAQLLH-----V-S--SP 433
KCNA2 402 IALPVPVIVSNFNYFYHRETEGEEQAQYLQ-----V-T--SC 435
KCNA3 472 IALPVPVIVSNFNYFYHRETEGEEQSQYMH-----V-G--SC 505
KCNA4 552 IALPVPVIVSNFNYFYHRETENEEQTQLTQ-----N-A-VSC 586
KCNA5 508 IALPVPVIVSNFNYFYHRETDHEEPAVLKEE--QGTQS--QG 545
KCNA6 450 IALPVPVIVSNFNYFYHRETEQEEQGQYTHV------T---- 481
KCNA7 386 ISLPVPVIVSNFSYFYHRETEGEEAGMFSHV------D---- 417
KCNA10 449 IALPVPVIVSNFNYFYHRETENEEKQNIPGEIERI------- 483
KCNB1 405 IALPIPIIVNNFSEFYKEQKRQEKAIKRREA--LER-AK--R 441
KCNB2 409 IALPIPIIVNNFSEFYKEQKRQEKAIKRREA--LER-AK--R 445
KCNC1 428 IAMPVPVIVNNFGMYYSLAMAKQKLPKKKKK--HIP-R--PP 464
KCNC2 465 IAMPVPVIVNNFGMYYSLAMAKQKLPRKRKK--HIP-P--AP 501
KCNC3 531 IAMPVPVIVNNFGMYYSLAMAKQKLPKKKNK--HIP-R--PP 567
KCNC4 464 IAMPVPVIVNNFGMYYSLAMAKQKLPKKRKK--HVP-R--PA 500
KCND1 400 IALPVPVIVSNFSRIYHQNQRADKRRAQQKV--RLA-RIRLA 438
KCND2 398 IALPVPVIVSNFSRIYHQNQRADKRRAQKKA--RLA-RIRAA 436
KCND3 395 IALPVPVIVSNFSRIYHQNQRADKRRAQKKA--RLA-RIRVA 433
KCNF1 398 IALPIHPIINNFVRYYNKQRVLETAAKHELE--LME-LN--- 433
KCNG1 452 MAFPVTSIFHTFSRSYLELKQEQERVMFRRA--QFL-I--KT 488
KCNG2 397 MAFPVTSIFHTFSRSYSELKEQQQRAASPEP--ALQ-E--DS 433
KCNG3 401 LALPITFIYHSFVQCYHELKFRSARYSR-------------- 428
KCNG4 446 MAFPATSIFHTFSHSYLELKKEQEQLQARLR--HLQ-N--TG 482
KCNV1 420 LALPIAIINDRFSACYFTLKLKEAAVRQREA--LKK-LT--K 456
KCNV2 485 NGMPISILYNKFSDYYSKLKAYEYTTIRRER--GEV-NF--- 520
KCNS1 449 VALPITIIFNKFSHFYRRQKALEAAVRNSNH--QEF-ED--- 484
KCNS2 402 VVLPITLIFNKFSHFYRRQKQLESAMRSCDF--GDG-MK--- 437
KCNS3 398 VALPITIIFNKFSKYYQKQKDIDVDQCSEDA--PEK-CH--- 433
cons 841 :* : : . 882
KCNQ1 378 AWRCY---A-AENPD-----SSTWKIYI-------------- 396
KCNQ2 343 AWRFY---A-TNLSRTD--LHSTWQYYE-------------- 364
KCNQ3 382 AWRYY---A-TNPNRID--LVATWRFYE-------------- 403
KCNQ4 349 AWRLY---S-TDMSRAY--LTATWYYYD-------------- 370
KCNQ5 377 VWRSY---A-ADE-KSV--SIATWK----------------- 394
KCNA1 434 -NLAS---D-S--D------L--------------------- 441
KCNA2 436 PKIPS---S-P-DL------K--------------------- 445
KCNA3 506 QHLSS-S-A-E-EL------R--------------------- 516
KCNA4 587 PYLPS-N-LLK-KF------R--------------------- 598
KCNA5 546 PGLDR-G-V-Q-RK------V--------------------- 556
KCNA6 482 ----C-G----------------------------------- 483
KCNA7 418 ----M-Q-P-C-GP------L--------------------- 424
KCNA10 484 ------------------------------------------ 483
KCNB1 442 NG---SIVS-M--N---------------------------- 449
KCNB2 446 NG---SIVS-M--N---------------------------- 453
KCNC1 465 QLGSP---N-Y-CKS-----VVNSPHHS-------------- 482
KCNC2 502 QASSP---T-F-CKT-----ELNMACNS-------------- 519
KCNC3 568 QPGSP---N-Y-CKPDPPPPPPPHPHHGSGGISPPPPITPPS 604
KCNC4 501 QLESP---M-Y-CKS-----EETSPRDS-------------- 518
KCND1 439 KSGTT---N-A-FLQYK--QNGGLEDSG--S-GEEQALCVRN 470
KCND2 437 KSGSA---N-A-YMQSK--RNGLLSNQLQ-SSEDEQAFVSKS 470
KCND3 434 KTGSS---N-A-YLHSK--RNGLLNEALELTGTPEEEHMGKT 468
KCNF1 434 -----SSSG-G--E---------------------------- 439
KCNG1 489 KSQLS---V-----------S--------------------- 495
KCNG2 434 THSAT---A-----------T--------------------- 440
KCNG3 429 -SLST---E-----------F--------------------- 434
KCNG4 483 PASEC---E-L-LDP-----H--------------------- 493
KCNV1 457 NIATDSYIS-V--N---------------------------- 467
KCNV2 521 -----MQRA-R--K--------K------------------- 527
KCNS1 485 -----LLSS-I--D--------G------------------- 491
KCNS2 438 -----EVPS-V--N---------------------------- 443
KCNS3 434 -----ELPY-F--N---------------------------- 439
cons 883 924
KCNQ1 397 ------------------------------------R-KA-- 399
KCNQ2 365 ------------------------------------R-TV-- 367
KCNQ3 404 ------------------------------------S-VV-- 406
KCNQ4 371 ------------------------------------S-IL-- 373
KCNQ5 395 ------------------------------------------ 394
KCNA1 442 ------------------------------------S-R--- 443
KCNA2 446 ------------------------------------K-S--- 447
KCNA3 517 ------------------------------------K-A--- 518
KCNA4 599 ------------------------------------S-S--- 600
KCNA5 557 ------------------------------------S-G--- 558
KCNA6 484 ------------------------------------------ 483
KCNA7 425 ------------------------------------E-G--- 426
KCNA10 484 ------------------------------------L-N--- 485
KCNB1 450 -----------M------------------------K-D--- 452
KCNB2 454 -----------L------------------------K-D--- 456
KCNC1 483 ------------------------------------T-Q--- 484
KCNC2 520 ------------------------------------T-Q--- 521
KCNC3 605 MGVTVAGAYPAGPHTHPGLLRGGAGGLGIMGLPPLPA-P--- 642
KCNC4 519 ------------------------------------T-C--- 520
KCND1 471 RSAFEQQHHHLL------------------------H-CLEK 487
KCND2 471 GSSFETQHHHLL------------------------H-CLEK 487
KCND3 469 TSLIESQHHHLL------------------------H-CLEK 485
KCNF1 440 -----------G------------------------KTG--- 443
KCNG1 496 ------------------------------------------ 495
KCNG2 441 ------------------------------------------ 440
KCNG3 435 ------------------------------------------ 434
KCNG4 494 ------------------------------------------ 493
KCNV1 468 -----------L------------------------R-D--- 470
KCNV2 528 -----------I------------------------A-E--- 530
KCNS1 492 -----------V------------------------S-E--- 494
KCNS2 444 -----------L------------------------R-D--- 446
KCNS3 440 -----------I------------------------R-D--- 442
cons 925 966
KCNQ1 400 -----------------PRSH--------------------- 403
KCNQ2 368 ---------------TVPMYS--SQT------QT-------- 378
KCNQ3 407 ---------------SFPFFR--------------------- 412
KCNQ4 374 -----------------PSFRELALL------FE-------- 384
KCNQ5 395 -----------------PHLK--------------------- 398
KCNA1 444 ---------------RS-----SS-T------MS-------- 450
KCNA2 448 ---------------RS-----AS-T------IS-------- 454
KCNA3 519 ---------------RS-----NS-T------LS-------- 525
KCNA4 601 ---------------TS-----SS-L------GD-------- 607
KCNA5 559 ---------------SR-----GS-F------CK-------- 565
KCNA6 484 ------------------------------------------ 483
KCNA7 427 ---------------KA-----NG-G------LV-------- 433
KCNA10 486 ---------------SV-----GS-R------MG-------- 492
KCNB1 453 ---------------AF-----AR-S------IE-----MMD 462
KCNB2 457 ---------------AF-----AR-S------ME-----LID 466
KCNC1 485 ---------------SD-----TC-P------LA-------- 491
KCNC2 522 ---------------SD-----TC-L------GK-------- 528
KCNC3 643 ---------------GE-----PC-P------LA-------- 649
KCNC4 521 ---------------SD-----TSPP------AR-------- 528
KCND1 488 TT--------------------------CHEFTD-------- 495
KCND2 488 TT--------------------------NHEFVD-------- 495
KCND3 486 TTGLSYLVDDPLLSVRT-----S--TIKNHEFID-------- 512
KCNF1 444 ---------------GS-----RS-D------LD-----NLP 453
KCNG1 496 ---------------QD-----SD-I------LFGSAS--SD 508
KCNG2 441 ---------------ED-----SS-Q------GPDSAGLADD 455
KCNG3 435 ---------------L-------------------------- 435
KCNG4 494 ---------------VA-----SE-H------EL-----MND 503
KCNV1 471 ---------------VY-----AR-S------IM-----EML 480
KCNV2 531 ---------------CL-----LG-S------NP-----QLT 540
KCNS1 495 ---------------AS-----LE-T------SR-----ETS 504
KCNS2 447 ---------------YY-----AH-K------VK-----SLM 456
KCNS3 443 ---------------IY-----AQ-R------MH-----TFI 452
cons 967 1008
KCNQ1 404 ------------------------------------------ 403
KCNQ2 379 Y-GAS----------------RLIPPLNQLELLRNLKSKSGL 403
KCNQ3 413 ------------------------------------------ 412
KCNQ4 385 H-VQR----------------ARNGGLRPLEVRRAPVPDGAP 409
KCNQ5 399 ----------------------------A------------- 399
KCNA1 451 --KSE-------------Y--MEI------------------ 457
KCNA2 455 --KSD-------------Y--MEI------------------ 461
KCNA3 526 --KSE-------------Y--MVI------------------ 532
KCNA4 608 --KSE-------------Y--LEM------------------ 614
KCNA5 566 --AGGTLENADSARRGSCP--LEK------------------ 585
KCNA6 484 ---QPAPDLRAT-DNGLGK--PDF------------------ 501
KCNA7 434 ------------------D--GEV------------------ 437
KCNA10 493 --STD-------------S--LNK------------------ 499
KCNB1 463 IVVEK-------------N--GEN------------------ 471
KCNB2 467 VAVEK-------------A--GES------------------ 475
KCNC1 492 --QEE-------------I--LEI------------------ 498
KCNC2 529 --DNR-------------L--LEH------------------ 535
KCNC3 650 --QEE-------------V--IEI------------------ 656
KCNC4 529 --EEG-------------M--IER------------------ 535
KCND1 496 -ELTF-------------S--EAL------------------ 503
KCND2 496 -EQVF-------------E--ESC------------------ 503
KCND3 513 -EQMF-------------E--QNC------------------ 520
KCNF1 454 PEPAG------------------------------------- 458
KCNG1 509 TRDN-------------------------------------- 512
KCNG2 456 SADAL----------------WVR------------------ 463
KCNG3 436 ------------------------------------------ 435
KCNG4 504 VNDLI----------------LEG------------------ 511
KCNV1 481 --RLK-------------G--RER------------------ 487
KCNV2 541 PRQE-------------------------------------- 544
KCNS1 505 QEGQS-------------ADLESQ------------------ 515
KCNS2 457 ASLTN-------------M--SRS------------------ 465
KCNS3 453 TSLSS-------------V--GIV------------------ 461
cons 1009 1050
KCNQ1 404 --------------------TLLSPSPKPKKSVVVKKKKFKL 425
KCNQ2 404 AFRKDPPPEPSPSKGSPCRGPLCGCCPGRSSQKVSLKDRV-F 444
KCNQ3 413 ----------------------KEQLEAASSQKLGLLDRVRL 432
KCNQ4 410 SRYPPVAT---------CHRPGSTSFCPGESSRMGIKDRIRM 442
KCNQ5 400 -----LHT---------CSPTKKEQGEASSSQKLSFKERVRM 427
KCNA1 458 ------------------------------------------ 457
KCNA2 462 ------------------------------------------ 461
KCNA3 533 ------------------------------------------ 532
KCNA4 615 ------------------------------------------ 614
KCNA5 586 ------------------------------------------ 585
KCNA6 502 ------------------------------------------ 501
KCNA7 438 ------------------------------------------ 437
KCNA10 500 ------------------------------------------ 499
KCNB1 472 ------------------------------------------ 471
KCNB2 476 ------------------------------------------ 475
KCNC1 499 ------------------------------------------ 498
KCNC2 536 ------------------------------------------ 535
KCNC3 657 ------------------------------------------ 656
KCNC4 536 ------------------------------------------ 535
KCND1 504 ------------------------------------------ 503
KCND2 504 ------------------------------------------ 503
KCND3 521 ------------------------------------------ 520
KCNF1 459 ------------------------------------------ 458
KCNG1 513 ------------------------------------------ 512
KCNG2 464 ------------------------------------------ 463
KCNG3 436 ------------------------------------------ 435
KCNG4 512 ------------------------------------------ 511
KCNV1 488 ------------------------------------------ 487
KCNV2 545 ------------------------------------------ 544
KCNS1 516 ------------------------------------------ 515
KCNS2 466 ------------------------------------------ 465
KCNS3 462 ------------------------------------------ 461
cons 1051 1092
KCNQ1 426 DKDN-GVTP-G----EKMLTVPHITCDPPEERRL-------- 453
KCNQ2 445 SSPR-GVAAKG----KGSPQAQTVRRSPSADQSLED-SPSKV 480
KCNQ3 433 SNPR-GSNTKG----KL--------FTPLNVDAIEE-SPSKE 460
KCNQ4 443 GSSQ-RRTGPS----KQHLAPPTMPTSPSSEQVGEATSPTKV 479
KCNQ5 428 ASPR-GQSIKS----RQ--ASVGDRRSPSTDITAEG-SPTKV 461
KCNA1 458 ---E-EDMNNS----IAHYRQV-NIR---------------- 474
KCNA2 462 ---Q-EGVNNSNE--D--FREE-NLK---------------- 478
KCNA3 533 ---E-EGGMNHSAFPQTPFKTG-N-S---------------- 552
KCNA4 615 ---E-EGVKES----LCAKEEKCQGK---------------- 632
KCNA5 586 ---C-N---VK----AKSNVD--------------------- 595
KCNA6 502 ---P-EANRER----RPSYLPT-------------------- 515
KCNA7 438 ---P-E-------------LPP-P------------------ 443
KCNA10 500 ---T-N------------G----------------------- 502
KCNB1 472 ---M-GKKDKV----QDNHLSPNKWKWTKRTLSET-SSSKSF 504
KCNB2 476 ---A-NTKDSA----DDNHLSPSRWKWARKALSET-SSNKSF 508
KCNC1 499 ---N-RADSKLNG--EVAKAALANEDCPHID-----QA---- 525
KCNC2 536 ---N-RS-------------VLSGDDSTGSE-----PP---- 551
KCNC3 657 ---N-RADPRPNG--DPAAAALAHEDCPAID-----QPA--- 684
KCNC4 536 ---K-RADSKQNG--D-ANAVLSDEEGAGLT-----QPLASS 565
KCND1 504 ---G-AVSPGG----R-TSRST-SVSSQPVGPGS--LLSSCC 533
KCND2 504 ---M-EVATVN----RPSSHSP-SLSSQQ----G--VTSTCC 530
KCND3 521 ---M-ESSMQN----YPSTRSP-SLSSHP----G--LTTTCC 547
KCNF1 459 ---K-EAPSCS----SRLKLSHSDTF-------IP-LLTE-- 482
KCNG1 513 ----------N------------------------------- 513
KCNG2 464 ---AG-----R------------------------------- 466
KCNG3 436 ----------N------------------------------- 436
KCNG4 512 ---PALPIMHM------------------------------- 519
KCNV1 488 ---A-STRSSG----GDDF--------------W-------- 499
KCNV2 545 ------------------------------------------ 544
KCNS1 516 ---A-PSEPPH----PQM------------------------ 525
KCNS2 466 ---S-PSELSL----NDSL----------------------- 476
KCNS3 462 ---V-SDPDST----DASSIEDNEDI-------CN-TTSLEN 487
cons 1093 1134
KCNQ1 454 DHFS---VDG------------YDSSVRKSPTLLEV---SMP 477
KCNQ2 481 PKSW-----S------------FGDRSRARQAF------RIK 499
KCNQ3 461 PKPV-----G------------LNNKERFRTAF------RMK 479
KCNQ4 480 QKSW-----S------------FNDRTRFRASL------RLK 498
KCNQ5 462 QKSW-----S------------FNDRTRFRPSL------RLK 480
KCNA1 475 ------------------------------------------ 474
KCNA2 479 ------------------------------------------ 478
KCNA3 553 ------------------------------------------ 552
KCNA4 633 ------------------------------------------ 632
KCNA5 596 ------------------------------------------ 595
KCNA6 516 ------------------------------------------ 515
KCNA7 444 ------------------------------------------ 443
KCNA10 503 ------------------------------------------ 502
KCNB1 505 ETKEQGSPEKA-------RSSSS-PQH-----LNVQQLEDMY 533
KCNB2 509 ENKYQEVSQKDSHEQLNNTSSSS-PQH-----LSAQKLEMLY 544
KCNC1 526 L----------------------------------------- 526
KCNC2 552 L----------------------------------------- 552
KCNC3 685 M----------------------------------------- 685
KCNC4 566 P----------------------------------------- 566
KCND1 534 P----------------------------------------- 534
KCND2 531 S----------------------------------------- 531
KCND3 548 S----------------------------------------- 548
KCNF1 483 ------------------------------------------ 482
KCNG1 514 ------------------------------------------ 513
KCNG2 467 ------------------------------------------ 466
KCNG3 437 ------------------------------------------ 436
KCNG4 520 ------------------------------------------ 519
KCNV1 500 ------------------------------------------ 499
KCNV2 545 ------------------------------------------ 544
KCNS1 526 ------------------------------------------ 525
KCNS2 477 ------------------------------------------ 476
KCNS3 488 CTA--------------------------------------- 490
cons 1135 1176
KCNQ1 478 -----------------HFMRTNSFAEDLDLEGETL------ 496
KCNQ2 500 G-------------AASRQNSEEASLPGEDIVDDKS------ 522
KCNQ3 480 A--------------YAFWQSSEDAGTGDPMAEDRG------ 501
KCNQ4 499 -----------------PRTSAEDA-PSEEVAEEKS------ 516
KCNQ5 481 S------------SQPKPVIDADTALGTDDVYDEKG------ 504
KCNA1 475 ------------------------------------------ 474
KCNA2 479 ------------------------------------------ 478
KCNA3 553 ------------------------------------------ 552
KCNA4 633 ------------------------------------------ 632
KCNA5 596 ------------------------------------------ 595
KCNA6 516 ------------------------------------------ 515
KCNA7 444 ------------------------------------------ 443
KCNA10 503 ------------------------------------------ 502
KCNB1 534 NKMAKTQ--SQPILNTKESAAQ-SKPKEELEMESIPSPVAPL 572
KCNB2 545 NEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQL 586
KCNC1 527 ------------------------------------------ 526
KCNC2 553 ------------------------------------------ 552
KCNC3 686 ------------------------------------------ 685
KCNC4 567 ------------------------------------------ 566
KCND1 535 ------------------------------------------ 534
KCND2 532 ------------------------------------------ 531
KCND3 549 ------------------------------------------ 548
KCNF1 483 ------------------------------------------ 482
KCNG1 514 ------------------------------------------ 513
KCNG2 467 ------------------------------------------ 466
KCNG3 437 ------------------------------------------ 436
KCNG4 520 ------------------------------------------ 519
KCNV1 500 ------------------------------------------ 499
KCNV2 545 ------------------------------------------ 544
KCNS1 526 ------------------------------------------ 525
KCNS2 477 ------------------------------------------ 476
KCNS3 491 ------------------------------------------ 490
cons 1177 1218
KCNQ1 497 ------------------------------------------ 496
KCNQ2 523 ------------------------------------------ 522
KCNQ3 502 ------------------------------------------ 501
KCNQ4 517 ------------------------------------------ 516
KCNQ5 505 ------------------------------------------ 504
KCNA1 475 ------------------------------------------ 474
KCNA2 479 ------------------------------------------ 478
KCNA3 553 ------------------------------------------ 552
KCNA4 633 ------------------------------------------ 632
KCNA5 596 ------------------------------------------ 595
KCNA6 516 ------------------------------------------ 515
KCNA7 444 ------------------------------------------ 443
KCNA10 503 ------------------------------------------ 502
KCNB1 573 P-TRTEGVIDMRSMSSIDSFISCATDFPEATRFSHSP---LT 610
KCNB2 587 AVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASH 628
KCNC1 527 ------------------------------------------ 526
KCNC2 553 ------------------------------------------ 552
KCNC3 686 ------------------------------------------ 685
KCNC4 567 ------------------------------------------ 566
KCND1 535 ------------------------------------------ 534
KCND2 532 ------------------------------------------ 531
KCND3 549 ------------------------------------------ 548
KCNF1 483 ------------------------------------------ 482
KCNG1 514 ------------------------------------------ 513
KCNG2 467 ------------------------------------------ 466
KCNG3 437 ------------------------------------------ 436
KCNG4 520 ------------------------------------------ 519
KCNV1 500 ------------------------------------------ 499
KCNV2 545 ------------------------------------------ 544
KCNS1 526 ------------------------------------------ 525
KCNS2 477 ------------------------------------------ 476
KCNS3 491 ------------------------------------------ 490
cons 1219 1260
KCNQ1 497 ------------------------------------------ 496
KCNQ2 523 ------------------------------------------ 522
KCNQ3 502 ------------------------------------------ 501
KCNQ4 517 ------------------------------------------ 516
KCNQ5 505 ------------------------------------------ 504
KCNA1 475 ------------------------------------------ 474
KCNA2 479 ------------------------------------------ 478
KCNA3 553 ------------------------------------------ 552
KCNA4 633 ------------------------------------------ 632
KCNA5 596 ------------------------------------------ 595
KCNA6 516 ------------------------------------------ 515
KCNA7 444 ------------------------------------------ 443
KCNA10 503 ------------------------------------------ 502
KCNB1 611 SLP------------SKTGGSTAPEVGW-RGALGASGG---R 636
KCNB2 629 LQMKFPTDLPGTEEHQRARGPPFLTLSREKGPAARDGTLEYA 670
KCNC1 527 ------------------------------------------ 526
KCNC2 553 ------------------------------------------ 552
KCNC3 686 ------------------------------------------ 685
KCNC4 567 ------------------------------------------ 566
KCND1 535 ------------------------------------------ 534
KCND2 532 ------------------------------------------ 531
KCND3 549 ------------------------------------------ 548
KCNF1 483 ------------------------------------------ 482
KCNG1 514 ------------------------------------------ 513
KCNG2 467 ------------------------------------------ 466
KCNG3 437 ------------------------------------------ 436
KCNG4 520 ------------------------------------------ 519
KCNV1 500 ------------------------------------------ 499
KCNV2 545 ------------------------------------------ 544
KCNS1 526 ------------------------------------------ 525
KCNS2 477 ------------------------------------------ 476
KCNS3 491 ------------------------------------------ 490
cons 1261 1302
KCNQ1 497 -------------------------LTPITHISQLREHHRAT 513
KCNQ2 523 -------------------------CPCEFVTEDLTPGLKVS 539
KCNQ3 502 -------------------------YGNDFPIEDMIPTLKAA 518
KCNQ4 517 -------------------------YQCELTVDDIMPAVKTV 533
KCNQ5 505 -------------------------CQCDVSVEDLTPPLKTV 521
KCNA1 475 --------------------------TAN----CTTAN--QN 484
KCNA2 479 --------------------------TAN----CTLAN--TN 488
KCNA3 553 --------------------------TAT----CTTNNNPNS 564
KCNA4 633 --------------------------GDD----SETDK--NN 642
KCNA5 596 ------------------------------------------ 595
KCNA6 516 ----------------------------------P-----HR 518
KCNA7 444 ----------------------------------------LW 445
KCNA10 503 ------------------------------------------ 502
KCNB1 637 F--VEANPSPD-------ASQHSSFFIESPKSSMKTNNPLKL 669
KCNB2 671 PVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKS 712
KCNC1 527 -------------------------TPDEGLPFTRSGTRERY 543
KCNC2 553 -------------------------SPPERLPIRRSSTRDKN 569
KCNC3 686 -------------------------SPEDKSPIT-PGSRGRY 701
KCNC4 567 -------------------------TPEERRALRRSTTRDRN 583
KCND1 535 -------------------------RRAKRRAIRLANSTASV 551
KCND2 532 -------------------------RRHK-KTFRIPNANVSG 547
KCND3 549 -------------------------RRSK-KTTHLPNSNLPA 564
KCNF1 483 ------------------------------------------ 482
KCNG1 514 ------------------------------------------ 513
KCNG2 467 ------------------------------------------ 466
KCNG3 437 ------------------------------------------ 436
KCNG4 520 ------------------------------------------ 519
KCNV1 500 ------------------------------------------ 499
KCNV2 545 ------------------------------------------ 544
KCNS1 526 ------------------------------------------ 525
KCNS2 477 ------------------------------------------ 476
KCNS3 491 ------------------------------------------ 490
cons 1303 1344
KCNQ1 514 IKVIRRMQ----------YFVAKKKFQQARKPYDVRDVIEQY 545
KCNQ2 540 IRAVCVMR----------FLVSKRKFKESLRPYDVMDVIEQY 571
KCNQ3 519 IRAVRILQ----------FRLYKKKFKETLRPYDVKDVIEQY 550
KCNQ4 534 IRSIRILK----------FLVAKRKFKETLRPYDVKDVIEQY 565
KCNQ5 522 IRAIRIMK----------FHVAKRKFKETLRPYDVKDVIEQY 553
KCNA1 485 CVNKSKLL----------TD---------------------- 494
KCNA2 489 YVNITKML----------TD---------------------- 498
KCNA3 565 CVNIKKIF----------TD---------------------- 574
KCNA4 643 CSNAKAVE----------TD---------------------- 652
KCNA5 596 ---LRRSLYALCLDTSRETD---------------------- 612
KCNA6 519 AYAEKRML----------TE---------------------- 528
KCNA7 446 APPGKHLV----------TE---------------------- 455
KCNA10 503 --GCSTEK----------SR---------------------- 510
KCNB1 670 RALKVNFM----------EG-------DPSPLLPVLGMYHDP 694
KCNB2 713 RSLKVNFK----------ENRGSAPQTPPSTARPLPVTTADF 744
KCNC1 544 --GP-CFL----------LSTGEYACPPGGGMRK-------- 564
KCNC2 570 RRGETCFL----------LTTGDYTCASDGGIRKG----YEK 597
KCNC3 702 SRDRACFL----------LT--DYAPSPDGSIRKATGAPPLP 731
KCNC4 584 KKAAACFL----------LSTGDYACA-DGSVRKG----TFV 610
KCND1 552 S-RGSMQE----------LDMLA--GLRRSHAPQSRSSLNAK 580
KCND2 548 SHQGSIQE----------LSTIQIRCVERTPLSNSRSSLNAK 579
KCND3 565 TRLRSMQE----------LSTIHIQGSEQPSLTTSRSSLNLK 596
KCNF1 483 ------------------------------------------ 482
KCNG1 514 ------------------------------------------ 513
KCNG2 467 ------------------------------------------ 466
KCNG3 437 ------------------------------------------ 436
KCNG4 520 ------------------------------------------ 519
KCNV1 500 ------------------------------------------ 499
KCNV2 545 ------------------------------------------ 544
KCNS1 526 ------------------------------------------ 525
KCNS2 477 ------------------------------------------ 476
KCNS3 491 ------------------------------------------ 490
cons 1345 1386
KCNQ1 546 SQGHLNLMVRIKELQRRL----------------DQSIGKPS 571
KCNQ2 572 SAGHLDMLSRIKSLQSRV----------------DQIVGRGP 597
KCNQ3 551 SAGHLDMLSRIKYLQTRI----------------DMIFTPGP 576
KCNQ4 566 SAGHLDMLGRIKSLQTRV----------------DQIVGRGP 591
KCNQ5 554 SAGHLDMLCRIKSLQTRV----------------DQILGKGQ 579
KCNA1 495 ------------------------------------------ 494
KCNA2 499 ------------------------------------------ 498
KCNA3 575 ------------------------------------------ 574
KCNA4 653 ------------------------------------------ 652
KCNA5 613 ------------------------------------------ 612
KCNA6 529 ------------------------------------------ 528
KCNA7 456 ------------------------------------------ 455
KCNA10 511 ------------------------------------------ 510
KCNB1 695 LRNRGSAAAAVAGLECATLLDKAVLSPESSIYTTASAKTPP- 735
KCNB2 745 SLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGPSKGLS- 785
KCNC1 565 --DLCKESP---VIAKYM------------------------ 577
KCNC2 598 SRSLNNIAGLAGNALRLS------------------------ 615
KCNC3 732 PQDWRKPGPPS-FLPDLN------------------------ 748
KCNC4 611 LRDLPLQHSP---EAACP------------------------ 625
KCND1 581 PHDSLDLNCDSRDFVAAI----------------ISIPTPP- 605
KCND2 580 MEECVKLNCEQPYVTTAI----------------ISIPTPP- 604
KCND3 597 ADDGLRPNCKTSQITTAI----------------ISIPTPP- 621
KCNF1 483 ------------------------------------------ 482
KCNG1 514 ------------------------------------------ 513
KCNG2 467 ------------------------------------------ 466
KCNG3 437 ------------------------------------------ 436
KCNG4 520 ------------------------------------------ 519
KCNV1 500 ------------------------------------------ 499
KCNV2 545 ------------------------------------------ 544
KCNS1 526 ------------------------------------------ 525
KCNS2 477 ------------------------------------------ 476
KCNS3 491 ------------------------------------------ 490
cons 1387 1428
KCNQ1 572 LFIS-----------V-----------------SEKSKDRGS 585
KCNQ2 598 AITD--KDR--T--KG-----------------PAEAELPED 616
KCNQ3 577 PSTP--KHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEI-ED 615
KCNQ4 592 GDRKAREKG--D--KG-----------------PSDAEVVDE 612
KCNQ5 580 ITSD-KKSR--E--KI-----------------TAEHETTDD 599
KCNA1 495 ------------------------------------------ 494
KCNA2 499 ------------------------------------------ 498
KCNA3 575 ------------------------------------------ 574
KCNA4 653 ------------------------------------------ 652
KCNA5 613 ------------------------------------------ 612
KCNA6 529 ------------------------------------------ 528
KCNA7 456 ------------------------------------------ 455
KCNA10 511 ------------------------------------------ 510
KCNB1 736 ------------------------------------------ 735
KCNB2 786 ------------------------------------------ 785
KCNC1 578 ------------------------------------------ 577
KCNC2 616 ------------------------------------------ 615
KCNC3 749 ------------------------------------------ 748
KCNC4 626 ------------------------------------------ 625
KCND1 606 ------------------------------------------ 605
KCND2 605 ------------------------------------------ 604
KCND3 622 ------------------------------------------ 621
KCNF1 483 ------------------------------------------ 482
KCNG1 514 ------------------------------------------ 513
KCNG2 467 ------------------------------------------ 466
KCNG3 437 ------------------------------------------ 436
KCNG4 520 ------------------------------------------ 519
KCNV1 500 ------------------------------------------ 499
KCNV2 545 ------------------------------------------ 544
KCNS1 526 ------------------------------------------ 525
KCNS2 477 ------------------------------------------ 476
KCNS3 491 ------------------------------------------ 490
cons 1429 1470
KCNQ1 586 NTIGARLNRVEDKVTQLDQRLALITDMLHQLLSLHGGSTP-- 625
KCNQ2 617 PSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAY 658
KCNQ3 616 QSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERLQVQVTEY 657
KCNQ4 613 ISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSAS--L 652
KCNQ5 600 LSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALAL 641
KCNA1 495 ------------------------------------------ 494
KCNA2 499 ------------------------------------------ 498
KCNA3 575 ------------------------------------------ 574
KCNA4 653 ------------------------------------------ 652
KCNA5 613 ------------------------------------------ 612
KCNA6 529 ------------------------------------------ 528
KCNA7 456 ------------------------------------------ 455
KCNA10 511 ------------------------------------------ 510
KCNB1 736 ------------------------------------------ 735
KCNB2 786 ------------------------------------------ 785
KCNC1 578 ------------------------------------------ 577
KCNC2 616 ------------------------------------------ 615
KCNC3 749 ------------------------------------------ 748
KCNC4 626 ------------------------------------------ 625
KCND1 606 ------------------------------------------ 605
KCND2 605 ------------------------------------------ 604
KCND3 622 ------------------------------------------ 621
KCNF1 483 ------------------------------------------ 482
KCNG1 514 ------------------------------------------ 513
KCNG2 467 ------------------------------------------ 466
KCNG3 437 ------------------------------------------ 436
KCNG4 520 ------------------------------------------ 519
KCNV1 500 ------------------------------------------ 499
KCNV2 545 ------------------------------------------ 544
KCNS1 526 ------------------------------------------ 525
KCNS2 477 ------------------------------------------ 476
KCNS3 491 ------------------------------------------ 490
cons 1471 1512
KCNQ1 626 --------------GSGGPPREGG--------AHITQPCGSG 645
KCNQ2 659 --FG--AKEPEPAPPYHSPEDSREH---VDRHGCIVKIVRSS 693
KCNQ3 658 ----------YPTKGTSSPAEAEK--KEDNRYSDLKTIICNY 687
KCNQ4 653 GAVQVPLFDPDITSDYHSPVDHEDISVSAQTL-SISRSVSTN 693
KCNQ5 642 ASFQIPPFECEQTSDYQSPVDSKDLSGSAQNSGCLSRSTSAN 683
KCNA1 495 ------------------------------------------ 494
KCNA2 499 ------------------------------------------ 498
KCNA3 575 ------------------------------------------ 574
KCNA4 653 ------------------------------------------ 652
KCNA5 613 ------------------------------------------ 612
KCNA6 529 ------------------------------------------ 528
KCNA7 456 ------------------------------------------ 455
KCNA10 511 ------------------------------------------ 510
KCNB1 736 ------------------------------------------ 735
KCNB2 786 ------------------------------------------ 785
KCNC1 578 ------------------------------------------ 577
KCNC2 616 ------------------------------------------ 615
KCNC3 749 ------------------------------------------ 748
KCNC4 626 ------------------------------------------ 625
KCND1 606 ------------------------------------------ 605
KCND2 605 ------------------------------------------ 604
KCND3 622 ------------------------------------------ 621
KCNF1 483 ------------------------------------------ 482
KCNG1 514 ------------------------------------------ 513
KCNG2 467 ------------------------------------------ 466
KCNG3 437 ------------------------------------------ 436
KCNG4 520 ------------------------------------------ 519
KCNV1 500 ------------------------------------------ 499
KCNV2 545 ------------------------------------------ 544
KCNS1 526 ------------------------------------------ 525
KCNS2 477 ------------------------------------------ 476
KCNS3 491 ------------------------------------------ 490
cons 1513 1554
KCNQ1 646 GS---------------------------------------- 647
KCNQ2 694 SSTGQ------------------KNFSAPPAAPPVQCPPSTS 717
KCNQ3 688 SETGPPEPP---------------YSFHQVTIDKVSPYGFFA 714
KCNQ4 694 M----------------------------------------- 694
KCNQ5 684 ISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSA 725
KCNA1 495 ------------------------------------------ 494
KCNA2 499 ------------------------------------------ 498
KCNA3 575 ------------------------------------------ 574
KCNA4 653 ------------------------------------------ 652
KCNA5 613 ------------------------------------------ 612
KCNA6 529 ------------------------------------------ 528
KCNA7 456 ------------------------------------------ 455
KCNA10 511 ------------------------------------------ 510
KCNB1 736 ----------RSPEKHTAIAFNF------------------- 748
KCNB2 786 ----------PRFPKQKLFPFSS------------------- 798
KCNC1 578 ------------------------------------------ 577
KCNC2 616 ------------------------------------------ 615
KCNC3 749 ------------------------------------------ 748
KCNC4 626 ------------------------------------------ 625
KCND1 606 ------------------------------------------ 605
KCND2 605 ------------------------------------------ 604
KCND3 622 ------------------------------------------ 621
KCNF1 483 ------------------------------------------ 482
KCNG1 514 ------------------------------------------ 513
KCNG2 467 ------------------------------------------ 466
KCNG3 437 ------------------------------------------ 436
KCNG4 520 ------------------------------------------ 519
KCNV1 500 ------------------------------------------ 499
KCNV2 545 ------------------------------------------ 544
KCNS1 526 ------------------------------------------ 525
KCNS2 477 ------------------------------------------ 476
KCNS3 491 ------------------------------------------ 490
cons 1555 1596
KCNQ1 648 ---------------------------VD------------- 649
KCNQ2 718 WQPQSHPRQG----H-GTSPVGDHGSLVRIPPP-PAHERS-- 751
KCNQ3 715 HDPVNLPRGGPSSGKVQATPPSSATTYVERPTVLPILTLL-- 754
KCNQ4 695 ------------------------------------------ 694
KCNQ5 726 VAATNTIANQ----I-NTAPKPAAPTTLQIPPPLPAIKHLPR 762
KCNA1 495 ------------------------------------------ 494
KCNA2 499 ------------------------------------------ 498
KCNA3 575 ------------------------------------------ 574
KCNA4 653 ------------------------------------------ 652
KCNA5 613 ------------------------------------------ 612
KCNA6 529 ------------------------------------------ 528
KCNA7 456 ------------------------------------------ 455
KCNA10 511 ------------------------------------------ 510
KCNB1 749 --------------------------------------EA-- 750
KCNB2 799 --------------------------------------RE-- 800
KCNC1 578 ------------------------------------------ 577
KCNC2 616 ------------------------------------------ 615
KCNC3 749 ------------------------------------------ 748
KCNC4 626 ------------------------------------------ 625
KCND1 606 ------------------------------------------ 605
KCND2 605 ------------------------------------------ 604
KCND3 622 ------------------------------------------ 621
KCNF1 483 ------------------------------------------ 482
KCNG1 514 ------------------------------------------ 513
KCNG2 467 ------------------------------------------ 466
KCNG3 437 ------------------------------------------ 436
KCNG4 520 ------------------------------------------ 519
KCNV1 500 ------------------------------------------ 499
KCNV2 545 ------------------------------------------ 544
KCNS1 526 ------------------------------------------ 525
KCNS2 477 ------------------------------------------ 476
KCNS3 491 ------------------------------------------ 490
cons 1597 1638
KCNQ1 650 ------------------------------------------ 649
KCNQ2 752 ------------------LSAYGGGNRASM---EFLRQEDTP 772
KCNQ3 755 ------------------DSRVSCHSQADL---QG-PYSDRI 774
KCNQ4 695 ------------------------------------------ 694
KCNQ5 763 PETLHPNPAGLQESISDVTTCLVASKENVQ---VA-QSNLTK 800
KCNA1 495 ------------------------------------------ 494
KCNA2 499 ------------------------------------------ 498
KCNA3 575 ------------------------------------------ 574
KCNA4 653 ------------------------------------------ 652
KCNA5 613 ------------------------------------------ 612
KCNA6 529 ------------------------------------------ 528
KCNA7 456 ------------------------------------------ 455
KCNA10 511 ------------------------------------------ 510
KCNB1 751 ------------------GVHQYIDADTDD---EG-QLLYSV 770
KCNB2 801 ------------------R-RSFTEIDTGDDEDFL-ELPGAR 822
KCNC1 578 ------------------------------------------ 577
KCNC2 616 ------------------------------------------ 615
KCNC3 749 ------------------------------------------ 748
KCNC4 626 ------------------------------------------ 625
KCND1 606 ------------------------------------------ 605
KCND2 605 ------------------------------------------ 604
KCND3 622 ------------------------------------------ 621
KCNF1 483 ------------------------------------------ 482
KCNG1 514 ------------------------------------------ 513
KCNG2 467 ------------------------------------------ 466
KCNG3 437 ------------------------------------------ 436
KCNG4 520 ------------------------------------------ 519
KCNV1 500 ------------------------------------------ 499
KCNV2 545 ------------------------------------------ 544
KCNS1 526 ------------------------------------------ 525
KCNS2 477 ------------------------------------------ 476
KCNS3 491 ------------------------------------------ 490
cons 1639 1680
KCNQ1 650 -----------------------PELFLPS----NTLPTYEQ 664
KCNQ2 773 GCR-PPEGNLRDSDTSISIPSVDHEELERSFSGFSISQSKEN 813
KCNQ3 775 SPR-QRRSITRDSDTPLSLMSVNHEELERSPSGFSISQDRDD 815
KCNQ4 695 ------------------------------------------ 694
KCNQ5 801 DRS-MRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEE 841
KCNA1 495 ------------------------------------------ 494
KCNA2 499 ------------------------------------------ 498
KCNA3 575 ------------------------------------------ 574
KCNA4 653 ------------------------------------------ 652
KCNA5 613 ------------------------------------------ 612
KCNA6 529 ------------------------------------------ 528
KCNA7 456 ------------------------------------------ 455
KCNA10 511 ------------------------------------------ 510
KCNB1 771 DSS-PPK---SLPGSTSPKFSTG--TRSEKNHFESSPLPTSP 806
KCNB2 823 EEKQVD----SSPNCFADKPSDGRDPLREEGSVGSSSPQDTG 860
KCNC1 578 ------------------------------------------ 577
KCNC2 616 ------------------------------------------ 615
KCNC3 749 ------------------------------------------ 748
KCNC4 626 ------------------------------------------ 625
KCND1 606 ------A---NTPD-----ESQPSSPGGGGRAGSTLRNSSLG 633
KCND2 605 ------V---TTPE-------------GDDRPE--SP----- 617
KCND3 622 ------A---LTPE-------------GESRPPPASPGPNTN 641
KCNF1 483 ------------------------------------------ 482
KCNG1 514 ------------------------------------------ 513
KCNG2 467 ------------------------------------------ 466
KCNG3 437 ------------------------------------------ 436
KCNG4 520 ------------------------------------------ 519
KCNV1 500 ------------------------------------------ 499
KCNV2 545 ------------------------------------------ 544
KCNS1 526 ------------------------------------------ 525
KCNS2 477 ------------------------------------------ 476
KCNS3 491 ------------------------------------------ 490
cons 1681 1722
KCNQ1 665 LTVPRRGPDEGS------------------------------ 676
KCNQ2 814 LDALNSCYAAVAPCAK---------VRPYIAEGES---DTDS 843
KCNQ3 816 YVFGPNGGSS---WMR---------EKRYLAEGET---DTDT 842
KCNQ4 695 ------------------------------------------ 694
KCNQ5 842 LNIQLSGSESSGSRGSQDFYPKWRESKLFITDEEVGPEETET 883
KCNA1 495 ------------------------------------------ 494
KCNA2 499 ------------------------------------------ 498
KCNA3 575 ------------------------------------------ 574
KCNA4 653 ------------------------------------------ 652
KCNA5 613 ------------------------------------------ 612
KCNA6 529 ------------------------------------------ 528
KCNA7 456 ------------------------------------------ 455
KCNA10 511 ------------------------------------------ 510
KCNB1 807 KFLRQNCIYSTEALTGKGPSGQEKC-----KL--------EN 835
KCNB2 861 HNCRQDI-YHAVSEVKKD-SSQEGC-----KM--------EN 887
KCNC1 578 ----PT------------------------------------ 579
KCNC2 616 ----PV------------------------------------ 617
KCNC3 749 ----AN------------------------------------ 750
KCNC4 626 ----PT------------------------------------ 627
KCND1 634 TPCLFP------------------------------------ 639
KCND2 618 -EYSGG------------------------------------ 622
KCND3 642 IPSIAS------------------------------------ 647
KCNF1 483 ------------------------------------------ 482
KCNG1 514 ------------------------------------------ 513
KCNG2 467 ------------------------------------------ 466
KCNG3 437 ------------------------------------------ 436
KCNG4 520 ------------------------------------------ 519
KCNV1 500 ------------------------------------------ 499
KCNV2 545 ------------------------------------------ 544
KCNS1 526 ------------------------------------------ 525
KCNS2 477 ------------------------------------------ 476
KCNS3 491 ------------------------------------------ 490
cons 1723 1764
KCNQ1 677 ------------------------------------------ 676
KCNQ2 844 DLCTPCGPPPRSATGEGPFGDVGWAGPR-------------- 871
KCNQ3 843 DPFTPSGSMPLSSTGDG-ISDSVWTPSNKP------------ 871
KCNQ4 695 ------------------------------------------ 694
KCNQ5 884 DTFDAAPQPAREAAFASDSLRTGRSRSSQSICKAGESTDALS 925
KCNA1 495 ------------------------------------------ 494
KCNA2 499 ------------------------------------------ 498
KCNA3 575 ------------------------------------------ 574
KCNA4 653 ------------------------------------------ 652
KCNA5 613 ------------------------------------------ 612
KCNA6 529 ------------------------------------------ 528
KCNA7 456 ------------------------------------------ 455
KCNA10 511 ------------------------------------------ 510
KCNB1 836 HI-SPDV-------------------------RVLPGGGAHG 851
KCNB2 888 HLFAPEI-------------------------HSNPGDTGYC 904
KCNC1 580 -----------------------------------------E 580
KCNC2 618 -----------------------------------------T 618
KCNC3 751 -----------------------------------------A 751
KCNC4 628 -----------------------------------------A 628
KCND1 640 -----------------------------------------E 640
KCND2 623 -----------------------------------------N 623
KCND3 648 -----------------------------------------N 648
KCNF1 483 -------------------------------------EKHHR 487
KCNG1 514 ------------------------------------------ 513
KCNG2 467 ------------------------------------------ 466
KCNG3 437 ------------------------------------------ 436
KCNG4 520 ------------------------------------------ 519
KCNV1 500 ------------------------------------------ 499
KCNV2 545 ------------------------------------------ 544
KCNS1 526 ------------------------------------------ 525
KCNS2 477 ------------------------------------------ 476
KCNS3 491 ------------------------------------------ 490
cons 1765 1806
KCNQ1 677 -------------------- 676
KCNQ2 872 ------K------------- 872
KCNQ3 872 ------I------------- 872
KCNQ4 695 ------D------------- 695
KCNQ5 926 LPHVKLK------------- 932
KCNA1 495 -------------------V 495
KCNA2 499 -------------------V 499
KCNA3 575 -------------------V 575
KCNA4 653 -------------------V 653
KCNA5 613 -------------------L 613
KCNA6 529 -------------------V 529
KCNA7 456 -------------------V 456
KCNA10 511 -------------------K 511
KCNB1 852 STRDQSI------------- 858
KCNB2 905 PTRETSM------------- 911
KCNC1 581 AVRV---------------T 585
KCNC2 619 SPYNSPCPLRRSRSPIPSIL 638
KCNC3 752 AAWIS--------------P 757
KCNC4 629 GTLFLP-------------H 635
KCND1 641 TVKISS-------------L 647
KCND2 624 IVRVSA-------------L 630
KCND3 649 VVKVSA-------------L 655
KCNF1 488 TRLQSCK------------- 494
KCNG1 514 -------------------- 513
KCNG2 467 -------------------- 466
KCNG3 437 -------------------- 436
KCNG4 520 -------------------- 519
KCNV1 500 ------F------------- 500
KCNV2 545 ------N------------- 545
KCNS1 526 ------Y------------- 526
KCNS2 477 ------R------------- 477
KCNS3 491 ------K------------- 491
cons 1807 1826
KCNH2 Paralogue Multiple Sequence Alignment
T-COFFEE, Version_8.99(Thu Feb 17 19:24:49 CET 2011 - Revision 594)
Cedric Notredame
CPU TIME:6 sec.
SCORE=59
*
BAD AVG GOOD
*
KCNH2 : 57
KCNH1 : 62
KCNH3 : 59
KCNH4 : 62
KCNH5 : 59
KCNH6 : 61
KCNH7 : 58
KCNH8 : 59
HCN1 : 54
HCN2 : 55
HCN3 : 61
HCN4 : 51
CNGA1 : 56
CNGA2 : 70
CNGA3 : 68
CNGA4 : 79
CNGB1 : 47
CNGB3 : 55
cons : 59
KCNH2 1 ---MPV--------------------------------------- 3
KCNH1 1 MTMAGG--------------------------------------- 6
KCNH3 1 ---MPA--------------------------------------- 3
KCNH4 1 ---MPV--------------------------------------- 3
KCNH5 1 --MPGG--------------------------------------- 4
KCNH6 1 ---MPV--------------------------------------- 3
KCNH7 1 ---MPV--------------------------------------- 3
KCNH8 1 ---MPV--------------------------------------- 3
HCN1 1 ---MEG--------------------------------------- 3
HCN2 1 ---MDA--------------------------------------- 3
HCN3 1 ---MEA--------------------------------------- 3
HCN4 1 ---MDK--------------------------------------- 3
CNGA1 1 ---MKL--------------------------------------- 3
CNGA2 1 ---MTE--------------------------------------- 3
CNGA3 1 ---MAK--------------------------------------- 3
CNGA4 1 ---MSQ--------------------------------------- 3
CNGB1 1 ---MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPN 42
CNGB3 1 --------------------------------------------- 0
cons 1 45
KCNH2 4 ----------------------RR----G-HVAPQNTFLDTI--- 18
KCNH1 7 ----------------------RR----G-LVAPQNTFLENI--- 21
KCNH3 4 ----------------------MR----G-LLAPQNTFLDTI--- 18
KCNH4 4 ----------------------MK----G-LLAPQNTFLDTI--- 18
KCNH5 5 ----------------------KR----G-LVAPQNTFLENI--- 19
KCNH6 4 ----------------------RR----G-HVAPQNTYLDTI--- 18
KCNH7 4 ----------------------RR----G-HVAPQNTFLGTI--- 18
KCNH8 4 ----------------------MK----G-LLAPQNTFLDTI--- 18
HCN1 4 ----------------------G---------------------- 4
HCN2 4 ---------------------------------------RG---- 5
HCN3 4 ----------------------E---------------------- 4
HCN4 4 ----------------------LPPSMRKRLYSLPQQVGAK---- 22
CNGA1 4 ----------------------SMK---NNIINTQQSFVTMPNVI 23
CNGA2 4 ----------------------K--------TNGVK--------S 10
CNGA3 4 -------------------------------INTQY--------S 9
CNGA4 4 --------------------------------------------- 3
CNGB1 43 PEEAETESESMPPEESFKEEEVAV-----ADPSPQETKEAAL--- 79
CNGB3 1 --------------------------------------------- 0
cons 46 90
KCNH2 19 IR----KFEGQSRKF-----------IIANA-RVEN-CAVI-YCN 45
KCNH1 22 VR----RS--NDTNF-----------VLGNA-QIVD-WPIV-YSN 46
KCNH3 19 AT----RFDGTHSNF-----------VLGNA-QVAGLFPVV-YCS 46
KCNH4 19 AT----RFDGTHSNF-----------LLANA-QGTRGFPIV-YCS 46
KCNH5 20 VR----RS--SESSF-----------LLGNA-QIVD-WPVV-YSN 44
KCNH6 19 IR----KFEGQSRKF-----------LIANA-QMEN-CAII-YCN 45
KCNH7 19 IR----KFEGQNKKF-----------IIANA-RVQN-CAII-YCN 45
KCNH8 19 AT----RFDGTHSNF-----------ILANA-QVAKGFPIV-YCS 46
HCN1 5 -------GKPNS--------------------------------- 9
HCN2 6 -G----GGRPGE--------------------------------- 12
HCN3 5 -------QRPAA--------------------------------- 9
HCN4 23 -A----WIMDEE--------------------------------E 30
CNGA1 24 VP----DIEKE------------I----------------R-RME 35
CNGA2 11 SP----AN-----------------------------------NH 16
CNGA3 10 HP----SRTH-------------L----------------KVKTS 21
CNGA4 4 --------------------------------------------- 3
CNGB1 80 TSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIP-QPVH-SIT 122
CNGB3 1 --------------------------------------------- 0
cons 91 135
KCNH2 46 DGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQI-------- 82
KCNH1 47 DGFCKLSGYHRAEVMQKSSTCSFMYGELTDKDTIEKV-------- 83
KCNH3 47 DGFCDLTGFSRAEVMQRGCACSFLYGPDTSELVRQQI-------- 83
KCNH4 47 DGFCELTGYGRTEVMQKTCSCRFLYGPETSEPALQRL-------- 83
KCNH5 45 DGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKV-------- 81
KCNH6 46 DGFCELFGYSRVEVMQQPCTCDFLTGPNTPSSAVSRL-------- 82
KCNH7 46 DGFCEMTGFSRPDVMQKPCTCDFLHGPETKRHDIAQI-------- 82
KCNH8 47 DGFCELAGFARTEVMQKSCSCKFLFGVETNEQLMLQI-------- 83
HCN1 10 --------------------------------------------- 9
HCN2 13 --------------------------------------------- 12
HCN3 10 --------------------------------------------- 9
HCN4 31 DAEEEG-AGGRQDPSRRSIRLRPLPSPSPSAAAGGTESRSSALGA 74
CNGA1 36 N----------------------------------GA-------- 38
CNGA2 17 NHHA------PPA-----------IKANGK-DDHRTS-------- 35
CNGA3 22 D-----------------------RDLNRA-EN--GL-------- 32
CNGA4 4 --------------------------------------------- 3
CNGB1 123 E----------------DPAQILGHGSTGDTGCTDEP-------- 143
CNGB3 1 --------------------------------------------- 0
cons 136 180
KCNH2 83 --------------------------------------------- 82
KCNH1 84 --------------------------------------------- 83
KCNH3 84 --------------------------------------------- 83
KCNH4 84 --------------------------------------------- 83
KCNH5 82 --------------------------------------------- 81
KCNH6 83 --------------------------------------------- 82
KCNH7 83 --------------------------------------------- 82
KCNH8 84 --------------------------------------------- 83
HCN1 10 ---------------------SSN--------------------- 12
HCN2 13 ---------------------SPGATPAPGPPPPPPPAPPQQQPP 36
HCN3 10 -------------------GASEGATP------------------ 17
HCN4 75 ADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSH 119
CNGA1 39 --------------------------------------------- 38
CNGA2 36 --------------------------------------------- 35
CNGA3 33 --------------------------------------------- 32
CNGA4 4 --------------------------------------------- 3
CNGB1 144 --------------------------------------------- 143
CNGB3 1 --------------------------------------------- 0
cons 181 225
KCNH2 83 --------------------------------------------- 82
KCNH1 84 --------------------------------------------- 83
KCNH3 84 --------------------------------------------- 83
KCNH4 84 --------------------------------------------- 83
KCNH5 82 --------------------------------------------- 81
KCNH6 83 --------------------------------------------- 82
KCNH7 83 --------------------------------------------- 82
KCNH8 84 --------------------------------------------- 83
HCN1 13 ------------------------------------------SRD 15
HCN2 37 PPPPPAPPPGPGPAPPQHPPRAEALPPEAADEGGPRGRLRSRDSS 81
HCN3 18 ----------------------------------------GLEAV 22
HCN4 120 GHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGASAQPAAS 164
CNGA1 39 --------------------------------------------- 38
CNGA2 36 --------------------------------------------- 35
CNGA3 33 --------------------------------------------- 32
CNGA4 4 --------------------------------------------- 3
CNGB1 144 --------------------------------------------- 143
CNGB3 1 --------------------------------------------- 0
cons 226 270
KCNH2 83 ----------------------------AQALLGAE--------E 91
KCNH1 84 ----------------------------RQTFENYE--------M 92
KCNH3 84 ----------------------------RKALDEHK--------E 92
KCNH4 84 ----------------------------HKALEGHQ--------E 92
KCNH5 82 ----------------------------RQTFDNYE--------S 90
KCNH6 83 ----------------------------AQALLGAE--------E 91
KCNH7 83 ----------------------------AQALLGSE--------E 91
KCNH8 84 ----------------------------EKSLEEKT--------E 92
HCN1 16 DGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAK--------E 52
HCN2 82 CGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPEGP--------A 118
HCN3 23 PPVAPPPA-----------T------------------------- 31
HCN4 165 PPPPQQPPQPAS--------------------------------- 176
CNGA1 39 ----------------------------CSSFSEDDD-SASTSEE 54
CNGA2 36 ----------------------------SRPHSAADDDTSSE--- 49
CNGA3 33 ----------------------------SRAHSSSEE-TSSVLQP 48
CNGA4 4 --------------------------------------------- 3
CNGB1 144 ----------------------------NEALEAQD--------T 152
CNGB3 1 --------------------------------------------- 0
cons 271 315
KCNH2 92 RKVE-IAFYRK-----------DGS-------------------- 104
KCNH1 93 NSFE-ILMYKK-----------NRT-------------------- 105
KCNH3 93 FKAE-LILYRK-----------SGL-------------------- 105
KCNH4 93 HRAE-ICFYRK-----------DGS-------------------- 105
KCNH5 91 NCFE-VLLYKK-----------NRT-------------------- 103
KCNH6 92 CKVD-ILYYRK-----------DAS-------------------- 104
KCNH7 92 RKVE-VTYYHK-----------NGS-------------------- 104
KCNH8 93 FKGE-IMFYKK-----------NGS-------------------- 105
HCN1 53 HGNS-VCFKVD---------------------------------- 62
HCN2 119 RGPK-VSFSCR---------------------------------- 128
HCN3 32 --------------------------------------------- 31
HCN4 177 -------ASCE---------------------------------- 180
CNGA1 55 SENEN-PH-AR-----------GSF-------------------- 66
CNGA2 50 ------LQ-RL-----------ADV-------------------- 56
CNGA3 49 GIAME-TR-GL-----------ADS-------------------- 60
CNGA4 4 --------------------------------------------- 3
CNGB1 153 RPGLRLLLWLEQNLERVLPQPPKSSEVWRDEPAVATGAASDPAPP 197
CNGB3 1 --------------------------------------------- 0
cons 316 360
KCNH2 105 CFLCLVDVV------------------------------------ 113
KCNH1 106 PVWFFVKIA------------------------------------ 114
KCNH3 106 PFWCLLDVI------------------------------------ 114
KCNH4 106 AFWCLLDMM------------------------------------ 114
KCNH5 104 PVWFYMQIA------------------------------------ 112
KCNH6 105 SFRCLVDVV------------------------------------ 113
KCNH7 105 TFICNTHII------------------------------------ 113
KCNH8 106 PFWCLLDIV------------------------------------ 114
HCN1 63 --------------------------------------------- 62
HCN2 129 --------------------------------------------- 128
HCN3 32 --------------------------------------------- 31
HCN4 181 --------------------------------------------- 180
CNGA1 67 SYKSLRKG-G----------------------------------- 75
CNGA2 57 D-APQQGRSG----------------------------------- 65
CNGA3 61 GQGSFTGQ-G----------------------------------- 69
CNGA4 4 --------------------------------------------- 3
CNGB1 198 GRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQAQ 242
CNGB3 1 --------------------------------------------- 0
cons 361 405
KCNH2 114 --------------------------------PVK---NEDGAVI 123
KCNH1 115 --------------------------------PIR---NEQDKVV 124
KCNH3 115 --------------------------------PIK---NEKGEVA 124
KCNH4 115 --------------------------------PIK---NEMGEVV 124
KCNH5 113 --------------------------------PIR---NEHEKVV 122
KCNH6 114 --------------------------------PVK---NEDGAVI 123
KCNH7 114 --------------------------------PVK---NQEGVAM 123
KCNH8 115 --------------------------------PIK---NEKGDVV 124
HCN1 63 ----------------------------------------GG--- 64
HCN2 129 ----------------------------------------GA--- 130
HCN3 32 -----------------------------------------A--- 32
HCN4 181 ----------------------------------------QP--- 182
CNGA1 76 --------------------------------PSQREQYLPGAIA 88
CNGA2 66 ---------------------------------FRRIVRLVGIIR 77
CNGA3 70 ---------------------------------IARLSRLIFLLR 81
CNGA4 4 --------------------------------------------- 3
CNGB1 243 TSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIG---EQEPDSP 284
CNGB3 1 --------------------------------------------- 0
cons 406 450
KCNH2 124 MFILNFEVVMEKDM-VG---------------------------- 139
KCNH1 125 LFLCTFSDITAFKQ-PI---------------------------- 140
KCNH3 125 LFLVSHKDISETK-NRG---------------------------- 140
KCNH4 125 LFLFSFKDITQSGSPGL---------------------------- 141
KCNH5 123 LFLCTFKDITLFKQ-PI---------------------------- 138
KCNH6 124 MFILNFEDLAQL--------------------------------- 135
KCNH7 124 MFIINFEYVTDNEN-AA---------------------------- 139
KCNH8 125 LFLASFKDITDTK-VKI---------------------------- 140
HCN1 65 ---------GGGGG-GGG--------------------------- 72
HCN2 131 ---------ASGPA-PGP--------------------------- 138
HCN3 33 ---------ASGPI-PKS--------------------------- 40
HCN4 183 ---------SVDTA-IKV--------------------------- 190
CNGA1 89 LFNVNNSSNKDQ--------------------------------- 100
CNGA2 78 EWANKNFREEEP--------------------------------- 89
CNGA3 82 RWAARHVHHQDQ--------------------------------- 93
CNGA4 4 ----------DT--------------------------------- 5
CNGB1 285 GICDVQTISILPGG---QVEPDLVLEEVEPPWEDAHQDVSTSPQG 326
CNGB3 1 --------------------------------------------- 0
cons 451 495
KCNH2 140 ----------------SPAH------------------------- 143
KCNH1 141 ----------------EDDS------------------------- 144
KCNH3 141 ----------------GPDR------------------------- 144
KCNH4 142 ----------------GPQG------------------------- 145
KCNH5 139 ----------------EDDS------------------------- 142
KCNH6 136 --------------------------------------------- 135
KCNH7 140 ----------------TPER------------------------- 143
KCNH8 141 ----------------TPE-------------------------- 143
HCN1 73 ----------------GGEE------------------------- 76
HCN2 139 ----------------GPAE------------------------- 142
HCN3 41 ----------------GPE-------------------------- 43
HCN4 191 ----------------EGGA------------------------- 194
CNGA1 101 ----------------EPEE------------------------- 104
CNGA2 90 ----------------RPDS------------------------- 93
CNGA3 94 ----------------GPDS------------------------- 97
CNGA4 6 --------------------------------------------- 5
CNGB1 327 TEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEEEEEEEEEEEEE 371
CNGB3 1 ----------------MFKSLTKVNKVKPIGENNENEQS------ 23
cons 496 540
KCNH2 144 ----------DTNHRGPPTSWLAPGRAKTFRLKLPALLALTARES 178
KCNH1 145 --------------------------CKGWG-------------- 149
KCNH3 145 ----------W----------------KETGGGRR---------- 153
KCNH4 146 ----------G----------------RGDSNHEN---------- 154
KCNH5 143 --------------------------TKGWT-------------- 147
KCNH6 136 ---------------------LAKCSSRSLSQRLLSQSFLGSEGS 159
KCNH7 144 ----------V-N----PILPIKTVNRKFFGFKFPGLRVLTYRKQ 173
KCNH8 144 -----------------------------DKKEDK---------- 149
HCN1 77 --------------------PA------GG---F----------- 81
HCN2 143 --------------------EA------GSEEAG----------- 150
HCN3 44 --------------------------------------------- 43
HCN4 195 ---------------------A------AGDQIL----------- 201
CNGA1 105 --------------------------------------------- 104
CNGA2 94 --------------------------------------------- 93
CNGA3 98 --------------------------------------------- 97
CNGA4 6 --------------------------------------------- 5
CNGB1 372 VTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKE 416
CNGB3 24 ----------------SRRNEEGSHPSNQSQQ----TTAQEENKG 48
cons 541 585
KCNH2 179 SVRSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVA 223
KCNH1 150 --------------------------------------------- 149
KCNH3 154 --------------------------------------------- 153
KCNH4 155 --------------------------------------------- 154
KCNH5 148 --------------------------------------------- 147
KCNH6 160 HGRPGGPG------------------------------------- 167
KCNH7 174 SLPQEDPD------VVVIDS----SKHSDDSVAMKHFKSPTKESC 208
KCNH8 150 --------------------------------------------- 149
HCN1 82 --------------------------------------------- 81
HCN2 151 --------------------------------------------- 150
HCN3 44 --------------------------------------------- 43
HCN4 202 --------------------------------------------- 201
CNGA1 105 --------------------------------------------- 104
CNGA2 94 --------------------------------------------- 93
CNGA3 98 --------------------------------------------- 97
CNGA4 6 --------------------------------------------- 5
CNGB1 417 AEEKAKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPAT 461
CNGB3 49 EEKSLKTKSTPVTSEEPHTNIQDKLSKKN---------SSGDLTT 84
cons 586 630
KCNH2 224 GLGPAEE---------------RRALV--GPGSP--PRSA--PGQ 247
KCNH1 150 --------------------------------------------- 149
KCNH3 154 --------------------------------------------- 153
KCNH4 155 --------------------------------------------- 154
KCNH5 148 --------------------------------------------- 147
KCNH6 168 ---PG---------------------------------------- 169
KCNH7 209 SPSEADD---------------TKALI--QPSKCSPLVNISGPLD 236
KCNH8 150 --------------------------------------------- 149
HCN1 82 --------------------------------------------- 81
HCN2 151 --------------------------------------------- 150
HCN3 44 --------------------------------------------- 43
HCN4 202 --------------------------------------------- 201
CNGA1 105 --------------------------------------------- 104
CNGA2 94 --------------------------------------------- 93
CNGA3 98 --------------------------------------------- 97
CNGA4 6 --------------------------------------------- 5
CNGB1 462 KQHPEVQVEDTDADSCPLMAEENPPSTVLPPPSPA---K------ 497
CNGB3 85 NPDPQNA-------------------------------A------ 92
cons 631 675
KCNH2 248 L--PSPRAHSLNPDASGSS------CSL----ARTRSRESCASVR 280
KCNH1 150 --------------------------------------------- 149
KCNH3 154 --------------------------RY----GRAR--------- 159
KCNH4 155 --------------------------SL----GRRG--------- 160
KCNH5 148 --------------------------------------------- 147
KCNH6 170 --------------------------------------------- 169
KCNH7 237 HSSPKRQWDRLYPDMLQSS------SQL----SHSRSRESLCSIR 271
KCNH8 150 --------------------------VK----GRSR--------- 155
HCN1 82 ---------------------------------E----------- 82
HCN2 151 ---------------------------------P----------- 151
HCN3 44 --------------------------------------------- 43
HCN4 202 ---------------------------------P----------- 202
CNGA1 105 --------------------------------------------- 104
CNGA2 94 --------------------------------------------- 93
CNGA3 98 --------------------------------------------- 97
CNGA4 6 --------------------------------------------- 5
CNGB1 498 ------------SDTLIVPSSASGTHRKKLPSEDDEA-E------ 523
CNGB3 93 ------------EPTGTVP-------------------------- 99
cons 676 720
KCNH2 281 RASSADDIEAM-------------RAGVLPPPPRHASTGAMHPLR 312
KCNH1 150 --------------------------------------------- 149
KCNH3 160 --------------------------------------------- 159
KCNH4 161 --------------------------------------------- 160
KCNH5 148 --------------------------------------------- 147
KCNH6 170 --------------------------------------------- 169
KCNH7 272 RASSVHDIEGFGV-----HPKNIFRDRHASEDNGRNVKGPFNHIK 311
KCNH8 156 --------------------------------------------- 155
HCN1 83 --------------------------------------------- 82
HCN2 152 --------------------------------------------- 151
HCN3 44 --------------------------------------------- 43
HCN4 203 --------------------------------------------- 202
CNGA1 105 --------------------------------------------- 104
CNGA2 94 --------------------------------------------- 93
CNGA3 98 --------------------------------------------- 97
CNGA4 6 --------------------------------------------- 5
CNGB1 524 ---ELKALSPAESPVVAWS-----DPTTPKDTDGQDRAASTASTN 560
CNGB3 100 ---EQKEMDPGKE-----------GPNSPQNK------PPAAPVI 124
cons 721 765
KCNH2 313 SGLLNSTSDSDLVRYR---TISKIPQITLNFVDLKGDPFLASP-T 353
KCNH1 150 -------------KFA------------------RLTRALTSS-R 162
KCNH3 160 --------------S----K--------------GFNANRRRS-R 171
KCNH4 161 --------------AT---W--------------KFRSARRRS-R 173
KCNH5 148 -------------KFA------------------RLTRALTNS-R 160
KCNH6 170 ---------TGRGKYR---TISQIPQFTLNFVEFNLEKHRSSS-T 201
KCNH7 312 SSLLGSTSDSNLNKYS---TINKIPQLTLNFSEVKTEKKNSSPPS 353
KCNH8 156 --------------AG---T--------------HFDSARRRS-R 168
HCN1 83 -----------------------------------DAEGPR-R-Q 90
HCN2 152 -----------------------------------AGEPRG-S-Q 159
HCN3 44 --------------------------------------------- 43
HCN4 203 -----------------------------------EAEVRL-G-Q 210
CNGA1 105 --------------KK---K-------------K-KKEKKSKS-D 117
CNGA2 94 --------------FL---E-------------R-FRGPELQT-V 106
CNGA3 98 --------------FP---D-------------R-FRGAELKE-V 110
CNGA4 6 ---------------------------------------KVKT-T 10
CNGB1 561 SAIINDRLQELVKLFKERTEKV-KEKLIDPDVTSDEE-SPKPSPA 603
CNGB3 125 NEYADAQLHNLVKRMRQRTALY-KKKLVEGDLSS-----PEASPQ 163
cons 766 810
KCNH2 354 -SDREIIA-P-KIK-E--R--TH--NVTEKVTQVLSLGADV-L-P 386
KCNH1 163 -GVLQQLA-PS-VQKG--E--NV--HKHSRLAEVLQLGSDI-L-P 196
KCNH3 172 -AVLYHLS-GH-LQK---Q--PK--G-KHKLNKGVFGEKPN-L-P 203
KCNH4 174 -TVLHRLT-GH-FGR---R--GQ--G-GMKANNNVFEPKPS-V-P 205
KCNH5 161 -SVLQQLT-PM-NKT---E--VV--HKHSRLAEVLQLGSDI-L-P 193
KCNH6 202 -TEIEIIA-PHKVV-E--R--TQ--NVTEKVTQVLSLGADV-L-P 235
KCNH7 354 -SDKTIIA-P-KVK-D--R--TH--NVTEKVTQVLSLGADV-L-P 386
KCNH8 169 -AVLYHIS-GH-LQR---R--EK--N-KLKINNNVFVDKPA-F-P 200
HCN1 91 YGFMQRQF--T-SM----L--QP--GVNKF-SLRMFGSQKA-V-E 121
HCN2 160 ASFMQRQF--G-AL----L--QP--GVNKF-SLRMFGSQKA-V-E 190
HCN3 44 --PKRRHL--G-TL----L--QP--TVNKF-SLRVFGSHKA-V-E 72
HCN4 211 AGFMQRQF--G-AM----L--QP--GVNKF-SLRMFGSQKA-V-E 241
CNGA1 118 -DKNENKNDPE-KKK---KK--------K-D-KEKKKK--E-EK- 143
CNGA2 107 -TTQEGDGKG--D-----------------------------KD- 118
CNGA3 111 -SSQESNAQ-A-NVG---SQEPADRGR-S-AWPLAKCNTNTSNNT 147
CNGA4 11 -ES------------------------------------------ 12
CNGB1 604 -KKAPEPA-PD-TKPAEAE--PV--EEEHYCDM-LCCKFKH-R-P 638
CNGB3 164 -TAKPTAV-PP-VKES--D--DK--PTEHYYRL-LWFKVKK-M-P 196
cons 811 855
KCNH2 387 -EYKLQAPRIHRWTILHYSPFKA-VWDWLILLLVIYTAVFTPYSA 429
KCNH1 197 -QYKQEAPKTPPHIILHYCVFKT-TWDWIILILTFYTAILVPYNV 239
KCNH3 204 -EYKVAAIRKSPFILLHCGALRA-TWDGFILLATLYVAVTVPYSV 246
KCNH4 206 -EYKVASVGGSRCLLLHYSVSKA-IWDGLILLATFYVAVTVPYNV 248
KCNH5 194 -QYKQEAPKTPPHIILHYCAFKT-TWDWVILILTFYTAIMVPYNV 236
KCNH6 236 -EYKLQAPRIHRWTILHYSPFKA-VWDWLILLLVIYTAVFTPYSA 278
KCNH7 387 -EYKLQTPRINKFTILHYSPFKA-VWDWLILLLVIYTAIFTPYSA 429
KCNH8 201 -EYKVSDAKKSKFILLHFSTFKA-GWDWLILLATFYVAVTVPYNV 243
HCN1 122 -KEQERVKTAGFWIIHPYSDFRF-YWDLIMLIMMVGNLVIIPVGI 164
HCN2 191 -REQERVKSAGAWIIHPYSDFRF-YWDFTMLLFMVGNLIIIPVGI 233
HCN3 73 -IEQERVKSAGAWIIHPYSDFRF-YWDLIMLLLMVGNLIVLPVGI 115
HCN4 242 -REQERVKSAGFWIIHPYSDFRF-YWDLTMLLLMVGNLIIIPVGI 284
CNGA1 144 SKDKKEEEKKEVVVIDPSGNTYY-NWLFCITLPVMYNWTMVIARA 187
CNGA2 119 GEDKGTKKKFELFVLDPAGDWYY-CWLFVIAMPVLYNWCLLVARA 162
CNGA3 148 EEE-KKTKKKDAIVVDPSSNLYY-RWLTAIALPVFYNWYLLICRA 190
CNGA4 13 SPPAPSKARKLLPVLDPSGDYYY-WWLNTMVFPVMYNLIILVCRA 56
CNGB1 639 -W----KKYQFPQSIDPLTNLMYVLWLFFVVMAWNWNCWLIPVRW 678
CNGB3 197 -LTEYLKRIKLPNSIDSYTDRLYLLWLLLVTLAYNWNCCFIPLRL 240
cons 856 : * : : 900
KCNH2 430 AFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDI-LINFRT 473
KCNH1 240 SFKTRQN------------NVAWLVVDSIVDVIFLVDI-VLNFHT 271
KCNH3 247 CVSTARE--------PSAARGPPSVCDLAVEVLFILDI-VLNFRT 282
KCNH4 249 CFSGDDD--------TPITSRHTLVSDIAVEMLFILDI-ILNFRT 284
KCNH5 237 SFKTKQN------------NIAWLVLDSVVDVIFLVDI-VLNFHT 268
KCNH6 279 AFLLSDQDE-SRRGACSYTCSPLTVVDLIVDIMFVVDI-VINFRT 321
KCNH7 430 AFLLNDREE-QKRRECGYSCSPLNVVDLIVDIMFIIDI-LINFRT 472
KCNH8 244 CFIGNDD--------LS-TTRSTTVSDIAVEILFIIDI-ILNFRT 278
HCN1 165 TFFTEQT------------TTPWIIFNVASDTVFLLDL-IMNFRT 196
HCN2 234 TFFKDET------------TAPWIVFNVVSDTFFLMDL-VLNFRT 265
HCN3 116 TFFKEEN------------SPPWIVFNVLSDTFFLLDL-VLNFRT 147
HCN4 285 TFFKDEN------------TTPWIVFNVVSDTFFLIDL-VLNFRT 316
CNGA1 188 CFDELQS----------DYLEYWLILDYVSDIVYLIDM-FVRTRT 221
CNGA2 163 CFSDLQK----------GYYLVWLVLDYVSDVVYIADL-FIRLRT 196
CNGA3 191 CFDELQS----------EYLMLWLVLDYSADVLYVLDV-LVRART 224
CNGA4 57 CFPDLQH----------GYLVAWLVLDYTSDLLYLLDM-VVRFHT 90
CNGB1 679 AFPYQTP----------DNIHHWLLMDYLCDLIYFLDITVFQTRL 713
CNGB3 241 VFPYQTA----------DNIHYWLIADIICDIIYLYDMLFIQPRL 275
cons 901 . : : : .:. *: ... : 945
KCNH2 474 TYVN-ANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLLIFGSG 516
KCNH1 272 TFVG-PAGEVISDPKLIRMNYLKTW-FVIDLLSCLPYDVINAFEN 314
KCNH3 283 TFVS-KSGQVVFAPKSICLHYVTTW-FLLDVIAALPFDLLHAF-K 324
KCNH4 285 TYVS-QSGQVISAPRSIGLHYLATW-FFIDLIAALPFDLLYIF-N 326
KCNH5 269 TFVG-PGGEVISDPKLIRMNYLKTW-FVIDLLSCLPYDIINAFEN 311
KCNH6 322 TYVN-TNDEVVSHPRRIAVHYFKGW-FLIDMVAAIPFDLLIFRTG 364
KCNH7 473 TYVN-QNEEVVSDPAKIAIHYFKGW-FLIDMVAAIPFDLLIFGSG 515
KCNH8 279 TYVS-KSGQVIFEARSICIHYVTTW-FIIDLIAALPFDLLYAF-N 320
HCN1 197 GTVNEDSSEIILDPKVIKMNYLKSW-FVVDFISSIPVDYIFLIVE 240
HCN2 266 GIVIEDNTEIILDPEKIKKKYLRTW-FVVDFVSSIPVDYIFLIVE 309
HCN3 148 GIVVEEGAEILLAPRAIRTRYLRTW-FLVDLISSIPVDYIFLVVE 191
HCN4 317 GIVVEDNTEIILDPQRIKMKYLKSW-FMVDFISSIPVDYIFLIVE 360
CNGA1 222 GYLE--QGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLG 264
CNGA2 197 GFLE--QGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVD 239
CNGA3 225 GFLE--QGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVG 267
CNGA4 91 GFLE--QGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYVRLG 133
CNGB1 714 QFVR--GGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVG 756
CNGB3 276 QFVR--GGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFG 318
cons 946 : :: : .* * :*. : :* * 990
KCNH2 517 SEE----------------------------------LIGLLKTA 527
KCNH1 315 VDEVSAFMGDPGKIGFADQ---IPPPLEGRESQGISSLFSSLKVV 356
KCNH3 325 VN----------------V---Y-------------FGAHLLKTV 337
KCNH4 327 IT----------------V---T-------------SLVHLLKTV 339
KCNH5 312 VDEG------------------------------ISSLFSSLKVV 326
KCNH6 365 SDE---------------T---T-------------TLIGLLKTA 378
KCNH7 516 SDE---------------T---T-------------TLIGLLKTA 529
KCNH8 321 VT----------------V---V-------------SLVHLLKTV 333
HCN1 241 K--GMDSEVYKTARALR-IVRFT-------------KILSLLRLL 269
HCN2 310 K--GIDSEVYKTARALR-IVRFT-------------KILSLLRLL 338
HCN3 192 LEPRLDAEVYKTARALR-IVRFT-------------KILSLLRLL 222
HCN4 361 T--RIDSEVYKTARALR-IVRFT-------------KILSLLRLL 389
CNGA1 265 WNY---------------------------------PEIRLNRLL 276
CNGA2 240 IHS---------------------------------PEVRFNRLL 251
CNGA3 268 TNY---------------------------------PEVRFNRLL 279
CNGA4 134 PHT---------------------------------PTLRLNRFL 145
CNGB1 757 VN----------------------------------PLLRLPRCL 767
CNGB3 319 FN----------------------------------PMFRANRML 329
cons 991 : 1035
KCNH2 528 RLLRLVRVARKLDRY-----SEYGAAV-LFLLMCTFALIAHWLAC 566
KCNH1 357 RLLRLGRVARKLDHY-----IEYGAAV-LVLLVCVFGLAAHWMAC 395
KCNH3 338 RLLRLLRLLPRLDRY-----SQYSAVV-LTLLMAVFALLAHWVAC 376
KCNH4 340 RLLRLLRLLQKLERY-----SQCSAVV-LTLLMSVFALLAHWMAC 378
KCNH5 327 RLLRLGRVARKLDHY-----LEYGAAV-LVLLVCVFGLVAHWLAC 365
KCNH6 379 RLLRLVRVARKLDRY-----SEYGAAV-LFLLMCTFALIAHWLAC 417
KCNH7 530 RLLRLVRVARKLDRY-----SEYGAAV-LMLLMCIFALIAHWLAC 568
KCNH8 334 RLLRLLRLLQKLDRY-----SQHSTIV-LTLLMSMFALLAHWMAC 372
HCN1 270 RLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGC 314
HCN2 339 RLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGC 383
HCN3 223 RLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGC 267
HCN4 390 RLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGC 434
CNGA1 277 RFSRMFEFFQRTETR-----TNYPNIFRISNLVMYIVIIIHWNAC 316
CNGA2 252 HFARMFEFFDRTETR-----TNYPNIFRISNLVLYILVIIHWNAC 291
CNGA3 280 KFSRLFEFFDRTETR-----TNYPNMFRIGNLVLYILIIIHWNAC 319
CNGA4 146 RAPRLFEAFDRTETR-----TAYPNAFRIAKLMLYIFVVIHWNSC 185
CNGB1 768 KYMAFFEFNSRLESI-----LSKAYVYRVIRTTAYLLYSLHLNSC 807
CNGB3 330 KYTSFFEFNHHLESI-----MDKAYIYRVIRTTGYLLFILHINAC 369
cons 1036 : : . : : : : * .* 1080
KCNH2 567 IWYAIGNMEQPHMDSR----IGWLHNLGDQIGKPYNSS------- 600
KCNH1 396 IWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFN------- 433
KCNH3 377 VWFYIGQREIESSESELPE-IGWLQELARRLETPYYLVGRRPAGG 420
KCNH4 379 IWYVIGRREMEANDPLLWD-IGWLHELGKRLEVPYVNG------- 415
KCNH5 366 IWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYN------- 403
KCNH6 418 IWYAIGNVERPYLEHK----IGWLDSLGVQLGKRYNGS------- 451
KCNH7 569 IWYAIGNVERPYLTDK----IGWLDSLGQQIGKRYNDS------- 602
KCNH8 373 IWYVIGKMEREDNSLLKWE-VGWLHELGKRLESPYYGNN------ 410
HCN1 315 LQFLVPLLQDFPPD-------CWVS-----LNEM----------- 336
HCN2 384 LQFLVPMLQDFPRN-------CWVS-----INGM----------- 405
HCN3 268 LQFLVPMLQDFPPD-------CWVS-----INHM----------- 289
HCN4 435 LQFLVPMLQDFPDD-------CWVS-----INNM----------- 456
CNGA1 317 VFYSISKAIGFGND-------TWVYPD---INDP----------- 340
CNGA2 292 IYYAISKSIGFGVD-------TWVYPN---ITDP----------- 315
CNGA3 320 IYFAISKFIGFGTD-------SWVYPN---ISIP----------- 343
CNGA4 186 LYFALSRYLGFGRD-------AWVYPD---PAQP----------- 209
CNGB1 808 LYYWASAYQGLGST-------HWVYD------------------- 826
CNGB3 370 VYYWASNYEGIGTT-------RWVYD------------------- 388
cons 1081 : : *: 1125
KCNH2 601 ---G------------------LGGPSIKDKYVTALYFTFSSLTS 624
KCNH1 434 -GSG-----------S--GK-WEGGPSKNSVYISSLYFTMTSLTS 463
KCNH3 421 NSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTS 465
KCNH4 416 ---------------------SVGGPSRRSAYIAALYFTLSSLTS 439
KCNH5 404 -T-S-----------A--GI-WEGGPSKDSLYVSSLYFTMTSLTT 432
KCNH6 452 ---D-----------P------ASGPSVQDKYVTALYFTFSSLTS 476
KCNH7 603 ---D-----------S------SSGPSIKDKYVTALYFTFSSLTS 627
KCNH8 411 ---------------------TLGGPSIRSAYIAALYFTLSSLTS 434
HCN1 337 -----------------------VNDSWGKQYSYALFKAMSHMLC 358
HCN2 406 -----------------------VNHSWSELYSFALFKAMSHMLC 427
HCN3 290 -----------------------VNHSWGRQYSHALFKAMSHMLC 311
HCN4 457 -----------------------VNNSWGKQYSYALFKAMSHMLC 478
CNGA1 341 -----------------------EFGRLARKYVYSLYWSTLTLTT 362
CNGA2 316 -----------------------EYGYLAREYIYCLYWSTLTLTT 337
CNGA3 344 -----------------------EHGRLSRKYIYSLYWSTLTLTT 365
CNGA4 210 -----------------------GFERLRRQYLYSFYFSTLILTT 231
CNGB1 827 --------------------------GVGNSYIRCYYFAVKTLIT 845
CNGB3 389 --------------------------GEGNEYLRCYYWAVRTLIT 407
cons 1126 * . : : : 1170
KCNH2 625 VGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSG 669
KCNH1 464 VGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYAN 508
KCNH3 466 VGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYAR 510
KCNH4 440 VGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSR 484
KCNH5 433 IGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYAN 477
KCNH6 477 VGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSG 521
KCNH7 628 VGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSG 672
KCNH8 435 VGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSR 479
HCN1 359 IGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSS 403
HCN2 428 IGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSS 472
HCN3 312 IGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSS 356
HCN4 479 IGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSS 523
CNGA1 363 IG-ETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAA 406
CNGA2 338 IG-ETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNAT 381
CNGA3 366 IG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNAS 409
CNGA4 232 VG-DTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTA 275
CNGB1 846 IG-GLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAG 889
CNGB3 408 IG-GLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATAN 451
cons 1171 :* . : : : : . .: ..* :. : 1215
KCNH2 670 TARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMN 714
KCNH1 509 TNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTE 553
KCNH3 511 RFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTT 555
KCNH4 485 RSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDAN 529
KCNH5 478 TNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTE 522
KCNH6 522 TARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMN 566
KCNH7 673 TARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMN 717
KCNH8 480 WSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSN 524
HCN1 404 RRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQG-KIFDEE 447
HCN2 473 RRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQG-KMFDED 516
HCN3 357 RRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQG-KMFDEE 400
HCN4 524 RRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQG-KMFDEE 567
CNGA1 407 RAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEK 451
CNGA2 382 RAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDER 426
CNGA3 410 RAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEK 454
CNGA4 276 DAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEV 320
CNGB1 890 QTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDES 934
CNGB3 452 QNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDES 496
cons 1216 : :: : :: : : 1260
KCNH2 715 AVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFK 759
KCNH1 554 KVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQ 598
KCNH3 556 ELLQSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALR 599
KCNH4 530 ELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIK 573
KCNH5 523 KVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQ 567
KCNH6 567 AVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFK 611
KCNH7 718 MVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFK 762
KCNH8 525 ELLKDFPDELRSDITMHLNKEIL-QLSLFECASRGCLRSLSLHIK 568
HCN1 448 NILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLR 492
HCN2 517 SILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLK 561
HCN3 401 SILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLR 445
HCN4 568 SILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLR 612
CNGA1 452 EVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQ 496
CNGA2 427 EILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLR 471
CNGA3 455 EVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLR 499
CNGA4 321 AILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQ 365
CNGB1 935 ELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLR 979
CNGB3 497 DLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLK 541
cons 1261 :: :: : . * . : : :: 1305
KCNH2 760 TTHAPPGDTLVHAGDLLTALYFISRGSIEILRG-D--VVVAILGK 801
KCNH1 599 TVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQD-D--EVVAILGK 640
KCNH3 600 PAFCTPGEYLIHQGDALQALYFVCSGSMEVLKG-G--TVLAILGK 641
KCNH4 574 TSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRD-N--MVLAILGK 615
KCNH5 568 TIHCAPGDLIYHAGESVDALCFVVSGSLEVIQD-D--EVVAILGK 609
KCNH6 612 TTHAPPGDTLVHLGDVLSTLYFISRGSIEILRD-D--VVVAILGK 653
KCNH7 763 TTHAPPGDTLVHCGDVLTALYFLSRGSIEILKD-D--IVVAILGK 804
KCNH8 569 TSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKD-S--MVLAILGK 610
HCN1 493 FEVFQPGDYIIREGAVGKKMYFIQHGVAGVITK-S--SKEMKLTD 534
HCN2 562 FEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK-G--NKEMKLSD 603
HCN3 446 FEVFQPGDLVVREGSVGRKMYFIQHGLLSVLAR-G--ARDTRLTD 487
HCN4 613 FEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK-G--NKETKLAD 654
CNGA1 497 PQVYSPGDYICKKGDIGREMYIIKEGKLAVVAD-DGVTQFVVLSD 540
CNGA2 472 PQVFSPGDYICRKGDIGKEMYIIKEGKLAVVAD-DGVTQYALLSA 515
CNGA3 500 PTVFSPGDYICKKGDIGKEMYIINEGKLAVVAD-DGVTQFVVLSD 543
CNGA4 366 PQTYSPGEYVCRKGDIGQEMYIIREGQLAVVAD-DGITQYAVLGA 409
CNGB1 980 SVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKA 1024
CNGB3 542 SVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKA 586
cons 1306 *.: : : * : * :: . * 1350
KCNH2 802 NDIFGEPLNLYAR------P----GKSNGDVRALTYCDLHKIHRD 836
KCNH1 641 GDVFGDVFWKEAT------L----AQSCANVRALTYCDLHVIKRD 675
KCNH3 642 GDLIGCELPRREQ------V----VKANADVKGLTYCVLQCLQLA 676
KCNH4 616 GDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSR 660
KCNH5 610 GDVFGDIFWKETT------L----AHACANVRALTYCDLHIIKRE 644
KCNH6 654 NDIFGEPVSLHAQ------P----GKSSADVRALTYCDLHKIQRA 688
KCNH7 805 NDIFGEMVHLYAK------P----GKSNADVRALTYCDLHKIQRE 839
KCNH8 611 GDLIGANLSIKDQ------V----IKTNADVKALTYCDLQCIILK 645
HCN1 535 GSYFGEICLLTKG------------RRTASVRADTYCRLYSLSVD 567
HCN2 604 GSYFGEICLLTRG------------RRTASVRADTYCRLYSLSVD 636
HCN3 488 GSYFGEICLLTRG------------RRTASVRADTYCRLYSLSVD 520
HCN4 655 GSYFGEICLLTRG------------RRTASVRADTYCRLYSLSVD 687
CNGA1 541 GSYFGEISILNIKGSKA--G----NRRTANIKSIGYSDLFCLSKD 579
CNGA2 516 GSCFGEISILNIKGSKM--G----NRRTANIRSLGYSDLFCLSKD 554
CNGA3 544 GSYFGEISILNIKGSKS--G----NRRTANIRSIGYSDLFCLSKD 582
CNGA4 410 GLYFGEISIINIKGNMS--G----NRRTANIKSLGYSDLFCLSKE 448
CNGB1 1025 GSVFGEISLLAVGG-----G----NRRTANVVAHGFTNLFILDKK 1060
CNGB3 587 GSVFGEISLLAAGG-----G----NRRTANVVAHGFANLLTLDKK 622
cons 1351 . :* : ..: . : * : 1395
KCNH2 837 DLLEVLDMYPEFSDHFWSSL--EIT-FNLRDTNM-IP-GSP---G 873
KCNH1 676 ALQKVLEFYTAFSHSFSRNL--ILT-YNLRKRIV-FRKISD-V-- 713
KCNH3 677 GLHDSLALYPEFAPRFSRGLRGELS-YNLGAGGG-SAEVDT-S-- 716
KCNH4 661 GLAEVLRLYPEYGAAFRAGLPRDLT-FNLRQGSD-TSGLSR-F-- 700
KCNH5 645 ALLKVLDFYTAFANSFSRNL--TLT-CNLRKRII-FRKISD-V-- 682
KCNH6 689 DLLEVLDMYPAFAESFWSKL--EVT-FNLRDAAG-G----L---H 722
KCNH7 840 DLLEVLDMYPEFSDHFLTNL--ELT-FNLRHESA-KA-DLLRSQS 879
KCNH8 646 GLFEVLDLYPEYAHKFVEDIQHDLT-YNLREGHE-SDVISR-L-- 685
HCN1 568 NFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSIL-LQKFQK---- 607
HCN2 637 NFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSIL-LHKVQH---- 676
HCN3 521 HFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSIL-QRKRSE---- 560
HCN4 688 NFNEVLEEYPMMRRAFETVALDRLDRIGKKNSIL-LHKVQH---- 727
CNGA1 580 DLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNI-ANAGSD-P-- 620
CNGA2 555 DLMEAVTEYPDAKKVLEERGREILMKEGLLDENE-VATS-M-E-- 594
CNGA3 583 DLMEALTEYPEAKKALEEKGRQILMKDNLIDEEL-ARAGAD-P-- 623
CNGA4 449 DLREVLSEYPQAQTIMEEKGREILLKMNKLDVNA-EAAEIA-L-- 489
CNGB1 1061 DLNEILVHYPESQKLLRKKARRMLRSNNKPK------EE-K-SVL 1097
CNGB3 623 TLQEILVHYPDSERILMKKARVLLKQKAKTA-EATPPRK-D-LAL 664
cons 1396 : : :. : : 1440
KCNH2 874 ----STELE-GGFSRQRKRKLSFRRRTDKDT--EQPGEVSALGPG 911
KCNH1 714 ----KREEE-ERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARL- 752
KCNH3 717 ------SLS-----G-------D--NTLMSTLEEKETDGEQG--- 738
KCNH4 701 ------SRS-PRLSQPRSESLGSSSDKTLPSITEAESGAEPGGGP 738
KCNH5 683 ----KKEEE-ERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRNQ 722
KCNH6 723 ----SSPRQ-APGSQDHQGFFLSDNQSGSPH--ELGPQFPSKGYS 760
KCNH7 880 ----MNDSE-GDNCKLRRRKLSFESEGEKE--------NSTNDPE 911
KCNH8 686 ------SNK-SMVSQSEPKGNGN-INKRLPSIVEDEEEEEEGEEE 722
HCN1 608 ------DLNTGVFNN-Q---ENEILKQIVKHDREMVQAIAPINYP 642
HCN2 677 ------DLNSGVFNN-Q---ENAIIQEIVKYDREMVQQAELGQRV 711
HCN3 561 ------PSPG----S-S---GGIMEQHLVQHDRDMARGVRGRAPS 591
HCN4 728 ------DLNSGVFNY-Q---ENEIIQQIVQHDREMAHCAHRVQAA 762
CNGA1 621 ----KDLEE-K---VTRME--GSVDLLQTRFARILAEYESMQQKL 655
CNGA2 595 ----VDVQE-K---LGQLE--TNMETLYTRFGRLLAEYTGAQQKL 629
CNGA3 624 ----KDLEE-K---VEQLG--SSLDTLQTRFARLLAEYNATQMKM 658
CNGA4 490 ----QEATE-SR--LRGLD--QQLDDLQTKFARLLAELESSALKI 525
CNGB1 1098 ILPPRAGTP-KL--FNAA--LAMTGKMGGKGAKGGKLAHLRARLK 1137
CNGB3 665 LFPPKEETP-KL--FKTL--LGGTGKASL------------ARLL 692
cons 1441 1485
KCNH2 912 RAGAGPSSRGRPGG---P--WGESPSSGPSS-------PESSEDE 944
KCNH1 753 AAERGGRDLDDLDV---E--KGNVLTEHASA-------NHSLVKA 785
KCNH3 739 P-TVSPAPADEPSS---P--LLSPGCTSSSSAAKLLSPRRTAPRP 777
KCNH4 739 RPR-RPLLLPNLSP---A--RPR--GSLVSLLGEELPPFSALVSS 775
KCNH5 723 GSTQGDPERNQLQV---E--SRSLQNGASIT-------GTSVVTV 755
KCNH6 761 LLGPG-SQNSMGAG---P--CAPG-HPDAAP-------PLSISDA 791
KCNH7 912 DSADTIRHYQSSKR---H--FEEKKSRSSSF-------ISSIDDE 944
KCNH8 723 EAVSLSPICTRGSS---S--RNKKVGSNKAYLGLSLKQLASGT-V 761
HCN1 643 QMTTLNSTSSTTTP---T--SRMRTQSPPVYT-------ATSLSH 675
HCN2 712 GLFPPPPPPPQVTS---A--IATLQQAAAMSF-------CPQVAR 744
HCN3 592 TGAQLSGKPVLWEP---L--VHAPLQAAAVTS-------NVAIAL 624
HCN4 763 ASATPTPTPVIWTP---L--IQAPLQAAAATT-------SVAIAL 795
CNGA1 656 KQRLTKVEKFLKP-----LIDTEFSSIEGPG---------AESGP 686
CNGA2 630 KQRITVLETKMKQ-----NNEDDYLSDGMNS---------PELAA 660
CNGA3 659 KQRLSQLESQVKG-----GG-DKPLADGEVPG-------DATKTE 690
CNGA4 526 AYRIERLEWQTREW---PMPEDLAEADDEGE---------PEEGT 558
CNGB1 1138 ELAALEAAAKQQEL---V--EQAKSSQDVKGE-------EGSAAP 1170
CNGB3 693 KLKREQAAQKKENSEGGE--EEGKENEDKQKE-------N-EDKQ 727
cons 1486 1530
KCNH2 945 GP---GRSSSPLRLVPFSSP-RPPGEPPGGEPLMEDC-------- 977
KCNH1 786 SV---VTVRESPATPVSFQA-ASTSGVPDHAKLQAPGS------- 819
KCNH3 778 RL---GGRGRPGRAGALKAE-AGPSAPPRALEG------------ 806
KCNH4 776 PS---LSPSLSPALAGQGHS-ASPHGPPRCSAAWKPPQ------- 809
KCNH5 756 SQ---ITPIQTSLAYVKTSE-SLKQNNRDAMELKPNGG------- 789
KCNH6 792 SG---LWPELLQEMPPRHSP-QSPQEDPDCWPLKLGSR------- 825
KCNH7 945 QK---PLFSGIVDSSPGIGK-ASGLDFEETVPTSGRMH------- 978
KCNH8 762 PF---HSPIRVSRSNSPKTK-QEIDPPNHNKRKEKNLK------- 795
HCN1 676 SNL-H--------------------------------------S- 680
HCN2 745 PLVGP---------------------------------------- 749
HCN3 625 THQRG--------P------------------------------- 630
HCN4 796 THHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSA 840
CNGA1 687 ID---S--------------------------------------- 689
CNGA2 661 AD---E--------------------------------------- 663
CNGA3 691 DK---Q--------------------------------------- 693
CNGA4 559 SK---DE-------E------------------------------ 563
CNGB1 1171 DQ----------HT-HPKEA------------------------- 1179
CNGB3 728 KE----------NEDKGKE-------------------------- 736
cons 1531 1575
KCNH2 978 --------------------------------------------- 977
KCNH1 820 --------------------------------------------- 819
KCNH3 807 --------------------------------------------- 806
KCNH4 810 --------------------------------------------- 809
KCNH5 790 --------------------------------------------- 789
KCNH6 826 --------------------------------------------- 825
KCNH7 979 --------------------------------------------- 978
KCNH8 796 --------------------------------------------- 795
HCN1 681 ----------------------------------PSPSTQTP--- 688
HCN2 750 ------------------------------------LALGSP--- 755
HCN3 631 ----------------------------------LPLSPDSP--- 638
HCN4 841 SPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPG 885
CNGA1 690 --------------------------------------------- 689
CNGA2 664 --------------------------------------------- 663
CNGA3 694 --------------------------------------------- 693
CNGA4 564 --------------------------------------------- 563
CNGB1 1180 --------------------------------------------- 1179
CNGB3 737 --------------------------------------------- 736
cons 1576 1620
KCNH2 978 --------------------------------------------- 977
KCNH1 820 --------------------------------------------- 819
KCNH3 807 --------------------------------------------- 806
KCNH4 810 --------------------------------------------- 809
KCNH5 790 --------------------------------------------- 789
KCNH6 826 --------------------------------------------- 825
KCNH7 979 --------------------------------------------- 978
KCNH8 796 --------------------------------------------- 795
HCN1 689 --------------QPSAIL------------------------- 694
HCN2 756 ----------------RLVR------------------------- 759
HCN3 639 ---------------ATLLA------------------------- 643
HCN4 886 ACGSPSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLLTPLQ 930
CNGA1 690 --------------------------------------------- 689
CNGA2 664 --------------------------------------------- 663
CNGA3 694 --------------------------------------------- 693
CNGA4 564 --------------------------------------------- 563
CNGB1 1180 --------------------------------------------- 1179
CNGB3 737 --------------------------------------------- 736
cons 1621 1665
KCNH2 978 ---------------------EKSSDTCNPLSG-AFSGVSNIFS- 999
KCNH1 820 --------------------ECLGPKGGGGDCAKRKSWA----R- 839
KCNH3 807 --------------------LRLPPMPWNVPPDLSPRVVDGIED- 830
KCNH4 810 --------------------LLIPPLGTFGPPDLSPRIVDGIED- 833
KCNH5 790 --------------------ADQKCLKVNSPIRMKNGNGKGWLR- 813
KCNH6 826 --------------------LEQLQAQMNRLESRVSSDLSRILQ- 849
KCNH7 979 --------------------IDKRSHSCKDITDMRSWERENAHP- 1002
KCNH8 796 --------------------LQLSTLNNAGPPDLSPRIVDGIED- 819
HCN1 695 ----SPCSYTTAVCSPPVQSPLAARTFHYASPTASQLSLMQ---- 731
HCN2 760 ---RPPPGPAPAAASPG------------PPPPASP--------- 780
HCN3 644 ---RSAWRSAGSPASPL------------VPVRAGPWASTS---- 669
HCN4 931 PGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQL 975
CNGA1 690 --------------------------------------------- 689
CNGA2 664 --------------------------------------------- 663
CNGA3 694 --------------------------------------------- 693
CNGA4 564 --------------------------------------------- 563
CNGB1 1180 ---------------------------A------T---------- 1181
CNGB3 737 ---------------------------N------E---------- 738
cons 1666 1710
KCNH2 1000 ------------------------FWGDS---R----G------- 1006
KCNH1 840 ------------------------FKDAC---G------------ 845
KCNH3 831 ------------------------GCGSD---Q------------ 836
KCNH4 834 ------------------------SGSTA---E----A------- 840
KCNH5 814 ------------------------LKNNM---G----A------- 820
KCNH6 850 ------------------------LLQKP---M----P------- 856
KCNH7 1003 ------------------------QPEDS---S----P------- 1009
KCNH8 820 ------------------------GNSSE---E----S------- 826
HCN1 732 -----------------------QQPQ------------------ 735
HCN2 781 -------------------------PG------------------ 782
HCN3 670 -----------------------RLPA------------------ 673
HCN4 976 GQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFT 1020
CNGA1 690 --------------------------------------------- 689
CNGA2 664 --------------------------------------------- 663
CNGA3 694 --------------------------------------------- 693
CNGA4 564 --------------------------------------------- 563
CNGB1 1182 -------------------------DPPA---------------- 1185
CNGB3 739 -------------------------DKDK---------------- 742
cons 1711 1755
KCNH2 1007 ----------------RQYQELPRCPAPTP-SLLNI--PL--SSP 1030
KCNH1 846 -------------------KSEDWNKVSKA-ESMET--LP--ER- 865
KCNH3 837 ----------------PKFSFRVGQSGPE--CSSSP--SP--GPE 859
KCNH4 841 ----------------PSFRFSRRPELPRP-RSQAP--PT--GTR 864
KCNH5 821 ----------------HEEKKEDWNNVTKA-ESMGL--LS--EDP 844
KCNH6 857 ----------------QGHASYILEAPASN-DLALV--PI--ASE 880
KCNH7 1010 ----------------SALQRAAWGISET---------------E 1023
KCNH8 827 ----------------QTFDFGSERIRSEP-RISPP--LG--DPE 850
HCN1 736 --QQ-------------VQQSQPPQTQPQQPS-PQPQTPGS---- 760
HCN2 783 --A-PA-------------SPRAPRTSPY---------------- 795
HCN3 674 --PP----------ARTLHASLSRAGRSQ-VSLLG--PP------ 697
HCN4 1021 PRGGLSPPGHSPGPPRTFPSAPPRASGSH-GSLLL--PPASSP-- 1060
CNGA1 690 ---------------------------T----------------- 690
CNGA2 664 ---------------------------P----------------- 664
CNGA3 694 ---------------------------Q----------------- 694
CNGA4 564 ----------------GRASQEGPPGPE----------------- 575
CNGB1 1186 ----------------PRTPPEPP---------G----SP--PSS 1199
CNGB3 743 ----------------GREPEEKPLDRPECTA-S----PI--AVE 764
cons 1756 1800
KCNH2 1031 GRRPRGDVE-SRLDALQRQLNRLETRLSADMATVLQ--------- 1065
KCNH1 866 -----TKAS------GEATLKKTDSCDSGITKSDLR--------- 890
KCNH3 860 SGLLTVPHG-PSEARNTDTLDKLRQAVTELSEQVLQ--------- 894
KCNH4 865 P-SPELASE-AEEVK--EKVCRLNQEISRLNQEVSQ--------- 896
KCNH5 845 KSSDSENSV------TKNPLRKTDSCDSGITKSDLR--------- 874
KCNH6 881 TTSPGPRLP-------QGFLPPAQTPSYGDLDDCSP--------- 909
KCNH7 1024 SDLTYGEVE-QRLDLLQEQLNRLESQMTTDIQTILQ--------- 1058
KCNH8 851 IGAAVLFIK-AEETK--QQINKLNSEVTTLTQEVSQ--------- 883
HCN1 761 STPKNEVHK-STQALHNTNLTREVRPLSASQPSLPHEVSTLISRP 804
HCN2 796 --GGLPAAPLAGPALPARRLSRASRPLSASQPSLPHGAPGPAAST 838
HCN3 698 ------------PGGGGRRLGPRGRPLSASQPSLPQRATGDGSPG 730
HCN4 1061 PPPQVPQRR-GTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRA 1104
CNGA1 691 --------------------------------------------- 690
CNGA2 665 --------------------------------------------- 664
CNGA3 695 --------------------------------------------- 694
CNGA4 576 --------------------------------------------- 575
CNGB1 1200 PPPAS---------L------------------------------ 1205
CNGB3 765 EEPHS---------V------------------------------ 770
cons 1801 1845
KCNH2 1066 -----LLQRQMTLVPPAYSAVTTP--------------------- 1084
KCNH1 891 -----LDNVGEARSPQDRSPILAEVKHSF-------------YPI 917
KCNH3 895 -----MREGLQSLRQAVQLVLAPHREGP----------------- 917
KCNH4 897 -----LSRELRHIMGLLQARLGPP------------------GHP 918
KCNH5 875 -----LDKAGEARSPLEHSPIQADAKHPF-------------YPI 901
KCNH6 910 -----KHRNSSPRMP--HLAVATD--------------------- 926
KCNH7 1059 -----LLQKQTTVVPPAYSMVTAGSEYQR-------------PII 1085
KCNH8 884 -----LGKDMRNVIQLLENVLSPQQPSRFCSLHSTSVCPSRESLQ 923
HCN1 805 HPTVG----ESLASIPQPVTAVPGTGLQ----------------- 828
HCN2 839 RPAS----------------------------------------- 842
HCN3 731 RKGS----------------------------------------- 734
HCN4 1105 SPHSSGESMAAFPLFPRAGGGSGGSG------------------- 1130
CNGA1 691 --------------------------------------------- 690
CNGA2 665 --------------------------------------------- 664
CNGA3 695 --------------------------------------------- 694
CNGA4 576 --------------------------------------------- 575
CNGB1 1206 --------------------------------------------- 1205
CNGB3 771 --------------------------------------------- 770
cons 1846 1890
KCNH2 1085 ---GPGPTSTSPLL-----PVSPLP-TLTLDSLSQVSQFMACEEL 1120
KCNH1 918 PEQTLQATVLEVRH-----ELKEDIKALNAKMTNIEKQLSEILRI 957
KCNH3 918 -CPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGTW 961
KCNH4 919 AGSAWTPDPPCPQL-----RP-----PCLSPCASRPPPSLQDTTL 953
KCNH5 902 PEQALQTTLQEVKH-----ELKEDIQLLSCRMTALEKQVAEILKI 941
KCNH6 927 ---KTLAPSSEQEQ-----PEGLWP-PLASPLHPLEVQGLICG-- 960
KCNH7 1086 QLMRTSQPEASIKT-----DRSFSPSSQCPEFLDLEKSKLKSKES 1125
KCNH8 924 TRTSWSAHQPCLHL-----QTGGAAYTQAQLCSSNITSDIWSVDP 963
HCN1 829 A-------GGRST--------------VP-QRVTLFRQMSSGAIP 851
HCN2 843 ---------SST-------------PRLG-P-------------- 850
HCN3 735 ---------GSE-------------R-LP-PSGLL-------AKP 748
HCN4 1131 --------SSGGLG-----PPGRPYGAIPGQHVTLPRKTSSGSLP 1162
CNGA1 691 --------------------------------------------- 690
CNGA2 665 --------------------------------------------- 664
CNGA3 695 --------------------------------------------- 694
CNGA4 576 --------------------------------------------- 575
CNGB1 1206 ---GRPEGEEEGPA-----EPEEHSVRIC---------------- 1226
CNGB3 771 ---RR----TVLPR-----GTSRQSLIIS---------------- 787
cons 1891 1935
KCNH2 1121 PPGAPELPQ------------------------------------ 1129
KCNH1 958 LTSRRS--------------------------------------- 963
KCNH3 962 PHPRPGPPPL--MAPWPWG-------PPASQSSP----------- 986
KCNH4 954 AEVH-CPASV--GTMETG--------TALLDLRP----------- 976
KCNH5 942 LSEKSVPQ------------------------------------- 949
KCNH6 961 --------------------------------------------- 960
KCNH7 1126 LSSGVHLNTA--SEDNLTSL------------------------- 1143
KCNH8 964 SSVGSSPQRT--GAHEQNPADSELYHSPSLDYSPSHYQVVQEGHL 1006
HCN1 852 ------PNRGVPPAPPPPA-------------------------- 864
HCN2 851 ---TP-AARAAAPSPDRRD-------------------------- 865
HCN3 749 ------PRTAQPPRPPVPE-------------------------- 761
HCN4 1163 PPLSLFGARATSSGGP-PL-------------------------- 1180
CNGA1 691 --------------------------------------------- 690
CNGA2 665 --------------------------------------------- 664
CNGA3 695 --------------------------------------------- 694
CNGA4 576 --------------------------------------------- 575
CNGB1 1227 --------------------------------------------- 1226
CNGB3 788 --------------------------------------------- 787
cons 1936 1980
KCNH2 1130 --------------------------------E--------G--P 1132
KCNH1 964 --------------------------------------------- 963
KCNH3 987 --WPRATAFWTSTSDSEPPASGDLCSEPSTPAS-------PP--P 1020
KCNH4 977 -----------SILPPYPSEPDPLG---------------PS--P 993
KCNH5 950 ---------------------------ASSPKS--------QMPL 959
KCNH6 961 --------------------------------------------P 961
KCNH7 1144 -------------LKQDSDLSLELHLRQRKTYV--------H--P 1165
KCNH8 1007 QFLRCISPHSDSTLTPLQSISATLSSSVCSSSETSLHLVLPS--R 1049
HCN1 865 --------------------------------------------- 864
HCN2 866 --------------------------------------------- 865
HCN3 762 --------------------------------------------- 761
HCN4 1181 --------------------------------------------- 1180
CNGA1 691 --------------------------------------------- 690
CNGA2 665 --------------------------------------------- 664
CNGA3 695 --------------------------------------------- 694
CNGA4 576 --------------------------------------------- 575
CNGB1 1227 --------------------------------------------- 1226
CNGB3 788 --------------------------------------------- 787
cons 1981 2025
KCNH2 1133 TRRLSLPGQLG---ALTSQP-LHRHGSDPG--------------- 1158
KCNH1 964 ------SQSPQ---ELFEISRPQSPESERDIFGA----------- 988
KCNH3 1021 SEEGAR-TGPA---EPVSQAEATSTGEPPPGSGGLALPWDPHSLE 1061
KCNH4 994 VPEASPPTPSL---LRHSFQSRSDTF------------------- 1016
KCNH5 960 QVP--PQIPCQ---DIFSVSRPESPESDKDEIH------------ 987
KCNH6 962 -CFSSLPEHLG---SVPKQLDFQRHGSDPGFAGSWG--------- 993
KCNH7 1166 IRHPSLPDSSL---STVGIVGLHRHVSDPGLPG------------ 1195
KCNH8 1050 SEEGSFSQGTV---SSFSLENLPGSWNQEGMASASTKPLENLPLE 1091
HCN1 865 ---AALPRESS---SVLNTD-P-DAEKP-RFASN----------- 889
HCN2 866 ---SASPGAAG---G---LD-PQDSARS-RLSSN----------- 888
HCN3 762 ---PATP------------------RGL-QLSAN----------- 773
HCN4 1181 ---TAGPQREP---G---AR-P-EPVRS-KLPSN----------- 1202
CNGA1 691 --------------------------------------------- 690
CNGA2 665 --------------------------------------------- 664
CNGA3 695 --------------------------------------------- 694
CNGA4 576 --------------------------------------------- 575
CNGB1 1227 ----MSPGPEPGEQILSVKMPEEREE-KAE--------------- 1251
CNGB3 788 ----MAPSAEGGEEVLTIEVKEKAKQ------------------- 809
cons 2026 2070
KCNH2 1159 ---------------------S 1159
KCNH1 989 ---------------------S 989
KCNH3 1062 MVLIGCHGSGTVQWTQEEGTGV 1083
KCNH4 1017 ---------------------H 1017
KCNH5 988 ---------------------F 988
KCNH6 994 ---------------------H 994
KCNH7 1196 ---------------------K 1196
KCNH8 1092 VVTS------TAEVKDNKAINV 1107
HCN1 890 ---------------------L 890
HCN2 889 ---------------------L 889
HCN3 774 ---------------------M 774
HCN4 1203 ---------------------L 1203
CNGA1 691 ---------------------- 690
CNGA2 665 ---------------------- 664
CNGA3 695 ---------------------- 694
CNGA4 576 ---------------------- 575
CNGB1 1252 ---------------------- 1251
CNGB3 810 ---------------------- 809
cons 2071 2092
SCN5A/CACNA1C Paralogue Multiple Sequence Alignment
T-COFFEE, Version_8.99(Thu Feb 17 19:24:49 CET 2011 - Revision 594)
Cedric Notredame
CPU TIME:30 sec.
SCORE=59
*
BAD AVG GOOD
*
CACNA1C : 57
CACNA1S : 64
CACNA1D : 58
CACNA1F : 60
CACNA1A : 53
CACNA1B : 62
CACNA1E : 61
CACNA1G : 56
CACNA1H : 50
CACNA1I : 51
SCN5A : 60
SCN1A : 61
SCN2A : 59
SCN3A : 61
SCN4A : 65
SCN7A : 67
SCN8A : 62
SCN9A : 62
SCN10A : 60
SCN11A : 63
cons : 59
CACNA1C 1 MVN-ENTRM--YIPEENHQ---GSNYGSPR------------ 24
CACNA1S 1 MEP--------------------------------------- 3
CACNA1D 1 MMM-M---M--MMKKMQHQRQQQA-DHANE------------ 23
CACNA1F 1 MSE-S---E------GG-----K--DTTPE------------ 13
CACNA1A 1 MAR-F---G--D----EM----PARYGGGG------------ 16
CACNA1B 1 MVR-F---G--D----EL----GGRYGGPG------------ 16
CACNA1E 1 MAR-F---G--E----AV----VARP---G------------ 13
CACNA1G 1 MDE-E-EDG--A----------------GAEESGQP-RS--- 18
CACNA1H 1 MTE-G-ARAADE-V--RV----P--LGAPPPGPAALVGASPE 31
CACNA1I 1 MAE-----S--A----------------SPPSSSAAAPA--- 16
SCN5A 1 ----M-ANF--L----------------LPRGTSSFRRFTRE 19
SCN1A 1 ---ME-QTV--L----------------VPPGPDSFNFFTRE 20
SCN2A 1 ---MA-QSV--L----------------VPPGPDSFRFFTRE 20
SCN3A 1 ---MA-QAL--L----------------VPPGPESFRLFTRE 20
SCN4A 1 MARPS-LCT--L----------------VPLGPECLRPFTRE 23
SCN7A 1 --------M--L----------------ASPEPKGLVPFTKE 16
SCN8A 1 ---MA-ARL--L----------------APPGPDSFKPFTPE 20
SCN9A 1 ------MAM--L----------------PPPGPQSFVHFTKQ 18
SCN10A 1 ----M-EFP--I----------------GSLETNNFRRFTPE 19
SCN11A 1 -MDDR-CYP--V----------------IFPDERNFRPFTSD 22
cons 1 42
CACNA1C 25 -PAHANMN--------A-NAAAG--L-A-P-EHI--PTPGAA 49
CACNA1S 4 ------------------------------------------ 3
CACNA1D 24 -ANYARGT--------R-LPLSG--E-G-P-TSQPNSSKQTV 50
CACNA1F 14 -PSPA-----------N---GAG--P-G-P-EWGLCPGP--- 32
CACNA1A 17 SGAAAGVV----------VGSGG--G-R-G-AGG--SRQG-G 40
CACNA1B 17 GGERA--------------RGGG--A-G-G-AGG--PGPGGL 37
CACNA1E 14 SGDGD--------------SDQS--R-N-R-QGT--PVPA-- 32
CACNA1G 19 -------F--------M--RLND--L-S-G---A--GGRP-- 32
CACNA1H 32 SPGAPGRE--------A--ERGS----ELG---V--SPSE-- 52
CACNA1I 17 ----A-----------E--PGVT--T-E-Q---P--GPRS-- 30
SCN5A 20 SLAAIEKRMAEK-QARGSTTLQESRE-G-LPEEE--APRPQL 56
SCN1A 21 SLAAIERRIAEE-KAKNPKP----DK-K-DDDEN--GPKPNS 53
SCN2A 21 SLAAIEQRIAEE-KAKRPKQ----ERKD-EDDEN--GPKPNS 54
SCN3A 21 SLAAIEKRAAEE-KAKKPKK----EQ-D-NDDEN--KPKPNS 53
SCN4A 24 SLAAIEQRAVEE-EARLQRNK----Q-M-EIEEP--ERKPRS 56
SCN7A 17 SFELIKQHIAKT------------HN-E-DHEEE--DLKPTP 42
SCN8A 21 SLANIERRIAES-KLKKPPKADGSHR-E-DDEDS--KPKPNS 57
SCN9A 19 SLALIEQRIAER-KSKEPKE----EK-K-DDDEE--APKPSS 51
SCN10A 20 SLVEIEKQIAAKQGT-KKAR-EKHRE-Q-KDQEE--KPRPQL 55
SCN11A 23 SLAAIEKRIAIQ-KEKKKS-----KD-Q-TGEVP--QPRPQL 54
cons 43 84
CACNA1C 50 LSWQ-AAIDAARQAKLMGSAGNATISTVSST-QRKRQQYGKP 89
CACNA1S 4 -----------------------------SSPQDEGLRKKQP 16
CACNA1D 51 LSWQ-AAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKS 91
CACNA1F 33 -P--------AV--------EGESSGASGLGTPKRRNQHSKH 57
CACNA1A 41 --------QPGA-----------QRMYKQSMAQRARTMALYN 63
CACNA1B 38 --------QPGQ-----------RVLYKQSIAQRARTMALYN 60
CACNA1E 33 ---------SGQ-----------AAAYKQTKAQRARTMALYN 54
CACNA1G 33 GPGS-AEKDP--------------G--SA-----------DS 46
CACNA1H 53 --SPAAERGA--------------EL-G------------AD 65
CACNA1I 31 --PPSSPPGL--------------EE-PL----------DG- 44
SCN5A 57 DLQA-SKKLPDLYGNPPQELIGEPLEDLDPFYSTQK-TFIVL 96
SCN1A 54 DLEA-GKNLPFIYGDIPPEMVSEPLEDLDPYYINKK-TFIVL 93
SCN2A 55 DLEA-GKSLPFIYGDIPPEMVSVPLEDLDPYYINKK-TFIVL 94
SCN3A 54 DLEA-GKNLPFIYGDIPPEMVSEPLEDLDPYYINKK-TFIVM 93
SCN4A 57 DLEA-GKNLPMIYGDPPPEVIGIPLEDLDPYYSNKK-TFIVL 96
SCN7A 43 DLEV-GKKLPFIYGNLSQGMVSEPLEDVDPYYYKKKNTFIVL 83
SCN8A 58 DLEA-GKSLPFIYGDIPQGLVAVPLEDFDPYYLTQK-TFVVL 97
SCN9A 52 DLEA-GKQLPFIYGDIPPGMVSEPLEDLDPYYADKK-TFIVL 91
SCN10A 56 DLKA-CNQLPKFYGELPAELIGEPLEDLDPFYSTHR-TFMVL 95
SCN11A 55 DLKA-SRKLPKLYGDIPRELIGKPLEDLDPFYRNHK-TFMVL 94
cons 85 126
CACNA1C 90 KKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIIL 131
CACNA1S 17 KKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIIL 58
CACNA1D 92 KKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFIL 133
CACNA1F 58 KTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILIL 99
CACNA1A 64 PIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMIL 105
CACNA1B 61 PIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMIL 102
CACNA1E 55 PIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMIL 96
CACNA1G 47 EAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISM 88
CACNA1H 66 EEQRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSM 107
CACNA1I 45 ADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECVSM 86
SCN5A 97 NKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFNMLIM 138
SCN1A 94 NKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIM 135
SCN2A 95 NKGKAISRFSATPALYILTPFNPIRKLAIKILVHSLFNMLIM 136
SCN3A 94 NKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSLFSMLIM 135
SCN4A 97 NKGKAIFRFSATPALYLLSPFSVVRRGAIKVLIHALFSMFIM 138
SCN7A 84 NKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQLFIL 125
SCN8A 98 NRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIM 139
SCN9A 92 NKGKTIFRFNATPALYMLSPFSPLRRISIKILVHSLFSMLIM 133
SCN10A 96 NKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSWFSLFIT 137
SCN11A 95 NRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHSLFSMFII 136
cons 127 : : * *. . 168
CACNA1C 132 LTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLI-IFTV 172
CACNA1S 59 LTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLI-VFSI 99
CACNA1D 134 LAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI-IFTV 174
CACNA1F 100 LTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLV-IFTV 140
CACNA1A 106 ATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIG-IFCF 146
CACNA1B 103 ATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIG-IFCF 143
CACNA1E 97 ATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIG-IFCF 137
CACNA1G 89 LVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
CACNA1H 108 LVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAV 149
CACNA1I 87 LVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAM 128
SCN5A 139 CTILTNCVFMAQHD-------PPPWT--KYVEYTFTA-IYTF 170
SCN1A 136 CTILTNCVFMTMSN-------PPDWT--KNVEYTFTG-IYTF 167
SCN2A 137 CTILTNCVFMTMSN-------PPDWT--KNVEYTFTG-IYTF 168
SCN3A 136 CTILTNCVFMTLSN-------PPDWT--KNVEYTFTG-IYTF 167
SCN4A 139 ITILTNCVFMTMSD-------PPPWS--KNVEYTFTG-IYTF 170
SCN7A 126 ISVLIDCVFMSLTN-------LPKWR--PVLENTLLG-IYTF 157
SCN8A 140 CTILTNCVFMTFSN-------PPDWS--KNVEYTFTG-IYTF 171
SCN9A 134 CTILTNCIFMTMNN-------PPDWT--KNVEYTFTG-IYTF 165
SCN10A 138 VTILVNCVCMTRTD-------LPE-----KIEYVFTV-IYTF 166
SCN11A 137 GTVIINCVFMATGPA-K--NSNSNNT--DIAECVFTG-IYIF 172
cons 169 :: :*: : . : .: . 210
CACNA1C 173 EAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQ 214
CACNA1S 100 EAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQ 141
CACNA1D 175 ETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQ 216
CACNA1F 141 ETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQ 182
CACNA1A 147 EAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTE 188
CACNA1B 144 EAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD 185
CACNA1E 138 EAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTH 179
CACNA1G 131 EMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDL 171
CACNA1H 150 EMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDG 190
CACNA1I 129 EMVLKMVALGI-FGKKCYLGDTWNRLDFFIVMAGMVEYSLDL 169
SCN5A 171 ESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKL 212
SCN1A 168 ESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL 209
SCN2A 169 ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL 210
SCN3A 168 ESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL 209
SCN4A 171 ESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDL 212
SCN7A 158 EILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPL 199
SCN8A 172 ESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNL 213
SCN9A 166 ESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNL 207
SCN10A 167 EALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDL 208
SCN11A 173 EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGI 214
cons 211 * :*:.* *. :: . ** :* : . 252
CACNA1C 215 ATKA-DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
CACNA1S 142 VNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
CACNA1D 217 LTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQ 258
CACNA1F 183 GPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLH 224
CACNA1A 189 F-----------------DLRTLRAVRVLRPLKLVSGIPSLQ 213
CACNA1B 186 F-----------------DLRTLRAVRVLRPLKLVSGIPSLQ 210
CACNA1E 180 FN-------------THVDLRTLRAVRVLRPLKLVSGIPSLQ 208
CACNA1G 172 Q---------------NVSFSAVRTVRVLRPLRAINRVPSMR 198
CACNA1H 191 H---------------NVSLSAIRTVRVLRPLRAINRVPSMR 217
CACNA1I 170 Q---------------NINLSAIRTVRVLRPLKAINRVPSMR 196
SCN5A 213 -----------------GNLSALRTFRVLRALKTISVIPGLK 237
SCN1A 210 -----------------GNVSALRTFRVLRALKTISVIPGLK 234
SCN2A 211 -----------------GNVSALRTFRVLRALKTISVIPGLK 235
SCN3A 210 -----------------GNVSALRTFRVLRALKTISVIPGLK 234
SCN4A 213 -----------------GNISALRTFRVLRALKTITVIPGLK 237
SCN7A 200 -----------------DFIPTLQTARTLRILKIIPLNQGLK 224
SCN8A 214 -----------------GNVSALRTFRVLRALKTISVIPGLK 238
SCN9A 208 -----------------GNVSALRTFRVLRALKTISVIPGLK 232
SCN10A 209 -----------------RGISGLRTFRVLRALKTVSVIPGLK 233
SCN11A 215 ----------------TIKLLPLRTFRVFRALKAISVVSRLK 240
cons 253 . ::: *.:* *: : :: 294
CACNA1C 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKT 297
CACNA1S 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKT 225
CACNA1D 259 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT 300
CACNA1F 225 IVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKT 266
CACNA1A 214 VVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTT 255
CACNA1B 211 VVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKA 252
CACNA1E 209 IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRA 250
CACNA1G 199 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
CACNA1H 218 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 259
CACNA1I 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNR 238
SCN5A 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHK 279
SCN1A 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNK 276
SCN2A 236 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNK 277
SCN3A 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNK 276
SCN4A 238 TIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQK 279
SCN7A 225 SLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHK 266
SCN8A 239 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNK 280
SCN9A 233 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHK 274
SCN10A 234 VIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNK 275
SCN11A 241 VIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLK 282
cons 295 :: :: : * : :* .* . ::.::* :: * :. 336
CACNA1C 298 CYNQEGI-----------------AD-V---PA---E----- 310
CACNA1S 226 CYF-I-G-----------------TD-I---VATVEN----- 239
CACNA1D 301 CFF-A-D-----------------SD-I---VA---E----- 311
CACNA1F 267 CYF-L-G-----------------SD-M---EA---E----- 277
CACNA1A 256 CFE-E-G-----------------TDDI----Q---G----- 266
CACNA1B 253 CFP-N-S-----------------TDA-----E---P----- 262
CACNA1E 251 CFM-N-N-----------------SGIL---EG---F----- 262
CACNA1G 241 CFL-P-ENFSLPLSVD------L-ERYYQTENE---DESPFI 270
CACNA1H 260 CFL-D-SAFVRNNNLTF-----L-RPYYQTEEG---EENPFI 290
CACNA1I 239 CFL-E-ENFTIQGDVA------L-PPYYQPEED---DEMPFI 268
SCN5A 280 CVR-N------------------FTA-L----N---G-TN-- 291
SCN1A 277 CIQ-WP-PTNASLEEHSI-EKNITVN-Y----N---G-TL-- 304
SCN2A 278 CLQ-WP-PDNSSFEINITSFFNNSLD-G----N---G-TT-- 306
SCN3A 277 CLQ-WP-PSDSAFETNTTSYFNGTMD-S----N---G-TF-- 305
SCN4A 280 CVR-WP-PPFN--DTNTTWYSNDTWY-G----N---D-TWYG 308
SCN7A 267 CFR-WP-QENE---------------------N---E-TLH- 280
SCN8A 281 CVV-WP------------------IN-F----N---E-SY-- 292
SCN9A 275 CFR-NS------------------LE-N----N---E-TL-- 286
SCN10A 276 CVK-N------------------DMA-V----N---E-TT-- 287
SCN11A 283 CIS-R------------------DCK-N----I---S-N--- 293
cons 337 * 378
CACNA1C 311 ------------------------------------------ 310
CACNA1S 240 ------------------------------------------ 239
CACNA1D 312 ------------------------------------------ 311
CACNA1F 278 ------------------------------------------ 277
CACNA1A 267 ------------------------------------------ 266
CACNA1B 263 ------------------------------------------ 262
CACNA1E 263 ------------------------------------------ 262
CACNA1G 271 CSQPRENG-------MRSCRSVPTLRGD---GGGGPPCG-LD 301
CACNA1H 291 CSSRRDNG-------MQKCSHIPGRRE------LRMPCT-LG 318
CACNA1I 269 CSLSGDNG-------IMGCHEIPPLKE------QGRECCLSK 297
SCN5A 292 -----------GS---------VEADGLVWESLDLYLSD-PE 312
SCN1A 305 -----------IN---------ETVFEF---DWKSYIQD-SR 322
SCN2A 307 -----------FN---------RTVSIF---NWDEYIED-KS 324
SCN3A 306 -----------VN---------VTMSTF---NWKDYIGD-DS 323
SCN4A 309 NEMWYGNDSWYANDTWNSHASWATNDTF---DWDAYISD-EG 346
SCN7A 281 ------------N---------RTG-------NPYYIRE-TE 293
SCN8A 293 -----------LE---------NGTKGF---DWEEYINN-KT 310
SCN9A 287 -----------ES---------IMNTLE---SEEDF----RK 301
SCN10A 288 -----------N--------------Y------S-SHRK-PD 296
SCN11A 294 -----------P---------------------E---AY-DH 299
cons 379 420
CACNA1C 311 ------D--DPSPCALETGHGRQ-CQN-GTVCKPGWDGPKHG 342
CACNA1S 240 ------E--EPSPCARTGSGR-R-CTINGSECRGGWPGPNHG 271
CACNA1D 312 ------E--DPAPCAFSGNGR-Q-CTANGTECRSGWVGPNGG 343
CACNA1F 278 ------E--DPSPCASSGSGR-A-CTLNQTECRGRWPGPNGG 309
CACNA1A 267 ------E--SPAPCGTEEPA-RT-C-PNGTKCQPYWEGPNNG 297
CACNA1B 263 ------V--GDFPCGKEAPA-RL-C-EGDTECREYWPGPNFG 293
CACNA1E 263 ------D--PPHPCGVQG------C-PAGYEC-KDWIGPNDG 288
CACNA1G 302 YEAYNS---------SSNTTC-VNWNQYYTNCSAGEHNPFKG 333
CACNA1H 319 WEAYTQP--QAEGVGAARNAC-INWNQYYNVCRSGDSNPHNG 357
CACNA1I 298 DDVYDFG--AGRQDLNASGLC-VNWNRYYNVCRTGSANPHKG 336
SCN5A 313 NYLLKNGTSDVLLCGNSSDAG-T-C-PEGYRCLKAGENPDHG 351
SCN1A 323 YHYFLEGFLDALLCGNSSDAG-Q-C-PEGYMCVKAGRNPNYG 361
SCN2A 325 HFYFLEGQNDALLCGNSSDAG-Q-C-PEGYICVKAGRNPNYG 363
SCN3A 324 HFYVLDGQKDPLLCGNGSDAG-Q-C-PEGYICVKAGRNPNYG 362
SCN4A 347 NFYFLEGSNDALLCGNSSDAG-H-C-PEGYECIKTGRNPNYG 385
SCN7A 294 NFYYLEGERYALLCGNRTDAG-Q-C-PEGYVCVKAGINPDQG 332
SCN8A 311 NFYTVPGMLEPLLCGNSSDAG-Q-C-PEGYQCMKAGRNPNYG 349
SCN9A 302 YFYYLEGSKDALLCGFSTDSG-Q-C-PEGYTCVKIGRNPDYG 340
SCN10A 297 IYINKRGTSDPLLCGNGSDSG-H-C-PDGYICLKTSDNPDFN 335
SCN11A 300 CFEKKENSPEFKMCGIWMGNS-A-C-SIQYECKHTKINPDYN 338
cons 421 * .* . 462
CACNA1C 343 ITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIY 384
CACNA1S 272 ITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIY 313
CACNA1D 344 ITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVY 385
CACNA1F 310 ITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVY 351
CACNA1A 298 ITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLY 339
CACNA1B 294 ITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLY 335
CACNA1E 289 ITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLY 330
CACNA1G 334 AINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF-YNFIY 374
CACNA1H 358 AINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSF-YNFIY 398
CACNA1I 337 AINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSF-YNFIY 377
SCN5A 352 YTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIY-MIF 392
SCN1A 362 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTY-MIF 402
SCN2A 364 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTY-MIF 404
SCN3A 363 YTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTY-MIF 403
SCN4A 386 YTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTY-MIF 426
SCN7A 333 FTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVY-MIF 373
SCN8A 350 YTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTY-MIF 390
SCN9A 341 YTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTY-MIF 381
SCN10A 336 YTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIY-MIF 376
SCN11A 339 YTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYS-VFF 379
cons 463 :*.: :: : ::: :: : : : . .: 504
CACNA1C 385 FVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLRE 426
CACNA1S 314 FVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLRE 355
CACNA1D 386 FVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLRE 427
CACNA1F 352 FVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQRE 393
CACNA1A 340 FIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRR 381
CACNA1B 336 FIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRR 377
CACNA1E 331 FIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRR 372
CACNA1G 375 FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
CACNA1H 399 FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARH 440
CACNA1I 378 FILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRY 419
SCN5A 393 FMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEK-EKR 433
SCN1A 403 FVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQK-EAE 443
SCN2A 405 FVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQK-EAE 445
SCN3A 404 FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQK-EAE 444
SCN4A 427 FVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEK-EEE 467
SCN7A 374 FVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKI-EPK 414
SCN8A 391 FVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQK-EAE 431
SCN9A 382 FVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQK-ELE 422
SCN10A 377 FVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAK-EKK 417
SCN11A 380 FIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAK-EKM 420
cons 505 *: : :. **:: .* * ::: : : .: 546
CACNA1C 427 KQQLEEDLKG------------YLDWITQA-ED--------- 446
CACNA1S 356 KQQLDEDLRG------------YMSWITQG-EV--------- 375
CACNA1D 428 KQQLEEDLKG------------YLDWITQA-ED--------- 447
CACNA1F 394 KQQMEEDLRG------------YLDWITQA-EE--------- 413
CACNA1A 382 QQQIERELNG------------YMEWISKA-EE--------- 401
CACNA1B 378 QQQIERELNG------------YLEWIFKA-EE--------- 397
CACNA1E 373 QQQIERELNG------------YRAWIDKA-EE--------- 392
CACNA1G 417 LSNASTLASFSEPGSCYEELLKYLVYILRKAAR--------- 449
CACNA1H 441 LSNDSTLASFSEPGSCYEELLKYVGHIFRKVKR--------- 473
CACNA1I 420 LS-SSTVASYAEPGDCYEEIFQYVCHILRKAKR--------- 451
SCN5A 434 FQEAMEMLKK------------EHEALTIRGVDTV------- 456
SCN1A 444 FQQMIEQLKK------------QQEAAQQAATATAS----EH 469
SCN2A 446 FQQMLEQLKK------------QQEEAQAAAAAASA-----E 470
SCN3A 445 FQQMLEQLKK------------QQEEAQAVAAASAA------ 468
SCN4A 468 FQQMLEKFKK------------HQEELEKAKAAQAL------ 491
SCN7A 415 FQQTGKELQE------------GNETDEAKTI---------- 434
SCN8A 432 FKAMLEQLKK------------QQEEAQAAAMATSAGTVSED 461
SCN9A 423 FQQMLDRLKK------------EQEEAEAIAAAAAE----YT 448
SCN10A 418 FQEALEMLRK------------EQEVLAALGIDTT------- 440
SCN11A 421 FQEAQQLLKE------------EKEALVAMGIDRS------- 443
cons 547 . 588
CACNA1C 447 --------IDPENE----------DE-GM------------- 456
CACNA1S 376 --------MDVEDF----------RE-GK------------- 385
CACNA1D 448 --------IDPENE----------EE-GG------------- 457
CACNA1F 414 --------LDMEDPSADDNLGSMAEE-GR------------- 433
CACNA1A 402 --------VILAED----------ET-DG------------- 411
CACNA1B 398 --------VMLAEE----------DR-NA------------- 407
CACNA1E 393 --------VMLAEE----------NK-NA------------- 402
CACNA1G 450 ----RLAQVSRA------------AGVRVGL----------- 464
CACNA1H 474 ----RSLRLYARW-----------QS-RWRK----------- 488
CACNA1I 452 ----RALGLYQAL-----------QS-RRQA----------- 466
SCN5A 457 ------------------------SR-SSLEMSPLAPVNSHE 473
SCN1A 470 SREPSAAGRL--------------SD-SSSEASKLSSKSAKE 496
SCN2A 471 SRDFSGAGGIGVF-----------SE-SSSVASKLSSKSEKE 500
SCN3A 469 SRDFSGIGGLGEL-----------LE-SSSEASKLSSKSAKE 498
SCN4A 492 ------------------------------------------ 491
SCN7A 435 ------------------------------------------ 434
SCN8A 462 AIEEEGEEGG-GS-----------PR-SSSEISKLSSKSAKE 490
SCN9A 449 SIRRSRIMGL--------------SE-SSSETSKLSSKSAKE 475
SCN10A 441 ------------------------SL-HSHNGSPLTSKNASE 457
SCN11A 444 ------------------------SL-TSLETSYFTPKKRKL 460
cons 589 630
CACNA1C 457 ----------------------DEE----------------- 459
CACNA1S 386 ----------------------L------------------- 386
CACNA1D 458 ----------------------EEG----------------- 460
CACNA1F 434 ----------------------AGH----------------- 436
CACNA1A 412 ----------------------EQRH---------------- 415
CACNA1B 408 ----------------------EEKS---------------- 411
CACNA1E 403 ----------------------GTSA---------------- 406
CACNA1G 465 ------------LSSPAP-LGGQETQPSSSCSRSHRR--LSV 491
CACNA1H 489 ------------KVDPSA-VQGQGPGHRQRRAG---RHTASV 514
CACNA1I 467 ------------L-GPEAPAPAK-PGPHAKEPR---HYHGKT 491
SCN5A 474 RRSKRRKR----MSSGTE-ECGEDRLPKSDSEDGPRA--MN- 507
SCN1A 497 RRNRRKKRKQKEQSGGEE-KDE-DEFQKSESEDSIRR--KGF 534
SCN2A 501 LKNRRKKKKQKEQSGEEE-KND--RVRKSESEDSIRR--KGF 537
SCN3A 499 WRNRRKKRRQREHLEGNN-KGERDSFPKSESEDSVKR--SSF 537
SCN4A 492 -------------EGGEA-DGD-------------------- 499
SCN7A 435 ------------------------------------------ 434
SCN8A 491 RRNRRKKRKQKELSEGEE-KGDPEKVFKSESEDGMRR--KAF 529
SCN9A 476 RRNRRKKKNQKKLSSGEE-KGDAEKLSKSESEDSIRR--KSF 514
SCN10A 458 RRHRIKPRV----SEGST-ED--NKSPRSDPYN-Q------- 484
SCN11A 461 FGNKKRKS----FFLRES-GK--DQPPGSDSDE--------- 486
cons 631 672
CACNA1C 460 ---------------------------------------KPR 462
CACNA1S 387 ------------------------------------------ 386
CACNA1D 461 ----------------------------------------KR 462
CACNA1F 437 ----------------------------------------RP 438
CACNA1A 416 -----------------------------------PFDGALR 422
CACNA1B 412 -----------------------------------PLDAVLK 418
CACNA1E 407 -----------------------------------L--EVLR 411
CACNA1G 492 -HHLVH------HHHHHHHHYHL-GNGTLRAPRASPEIQDRD 525
CACNA1H 515 HHLVYH------HHHHHHHHYHF-SHGSPRRPGPEPGACDTR 549
CACNA1I 492 KGQGDE------GRHLGSRHCQT-LHGP-------------- 512
SCN5A 508 ------------------HLSLTRGLSRTSMKPRSSRGS-IF 530
SCN1A 535 RFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTS-LF 575
SCN2A 538 RFSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRAS-LF 578
SCN3A 538 LFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTS-IF 578
SCN4A 500 ------------------------------------------ 499
SCN7A 435 ------------------------------------------ 434
SCN8A 530 RLP-D-NRIG--RKFSIMNQSLLSIPGSPFLSRHNSKSS-IF 566
SCN9A 515 HLGVEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTS-LF 555
SCN10A 485 --------------------RRMSFLGLASGKRRASHGS-VF 505
SCN11A 487 ------------------------------------------ 486
cons 673 714
CACNA1C 463 -N---------------------------------------- 463
CACNA1S 387 -S---------------------------------------- 387
CACNA1D 463 -N---------------------------------------- 463
CACNA1F 439 QL---------------------------------------- 440
CACNA1A 423 -R---------------------------------------- 423
CACNA1B 419 -R---------------------------------------- 419
CACNA1E 412 -R---------------------------------------- 412
CACNA1G 526 -ANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHADCHLEPV 566
CACNA1H 550 -LVRAG----APPSPPSPGRGPP-DAESVHSIYHADCHIEGP 585
CACNA1I 513 ------------AS---PGN-----DHSGRELCPQHSPLDAT 534
SCN5A 531 -T--FRR-------RDLGSEADFADDENSTAGESESHHTSLL 562
SCN1A 576 -S--FRG-----RAKDVGSENDFADDEHSTFEDNESRRDSLF 609
SCN2A 579 -S--FRG-----RAKDIGSENDFADDEHSTFEDNDSRRDSLF 612
SCN3A 579 -S--FRG-----RAKDVGSENDFADDEHSTFEDSESRRDSLF 612
SCN4A 500 ------------------------------------------ 499
SCN7A 435 ------------------------------------------ 434
SCN8A 567 -S--FRGP---GRFRDPGSENEFADDEHSTVEESEGRRDSLF 602
SCN9A 556 -S--FKG-----RGRDIGSETEFADDEHSIFGDNESRRGSLF 589
SCN10A 506 -H--FRSP-----GRDISLPEGVTDDG-VFPGDHESHRGSLL 538
SCN11A 487 ------------------------------------------ 486
cons 715 756
CACNA1C 464 ------------------------------------M---SM 466
CACNA1S 388 ------------------------------------L---DE 390
CACNA1D 464 ------------------------------------T---SM 466
CACNA1F 441 ------------------------------------A---EL 443
CACNA1A 424 ------------------------------------T---TI 426
CACNA1B 420 ------------------------------------A---AT 422
CACNA1E 413 ------------------------------------A---TI 415
CACNA1G 567 RCQAPPPRSP--SEA--SGRTV--GSG----KV-YPTVHTSP 597
CACNA1H 586 QERARVAHAA--ATAAASLR-LATGLG----TMNYPTILPSG 620
CACNA1I 535 PHTLVQPIPA--TLASD-----P---A----SCPCCQHEDGR 562
SCN5A 563 VPWPL--RRTSAQGQ--PSP--GTSA----PGH-ALHGKKNS 593
SCN1A 610 VPRRHGERRN---------S--NLSQ----TSR-SSRMLAVF 635
SCN2A 613 VPHRHGERRH---------S--NVSQ----ASR-ASRVLPIL 638
SCN3A 613 VPHRHGERRN---------S--NVSQ----ASM-SSRMVPGL 638
SCN4A 500 ------------------------------------------ 499
SCN7A 435 ------------------------------------------ 434
SCN8A 603 IPIRARERRS--SYS--GYS--GYSQ----GSR-SSRIFPSL 633
SCN9A 590 VPHRPQERRS---------S--NISQ----ASR-SP---PML 612
SCN10A 539 LGGGAGQQG----------P--LPRSPLPQPSN-P------D 561
SCN11A 487 ------------------------------------------ 486
cons 757 798
CACNA1C 467 P----T------------------------------------ 468
CACNA1S 391 G----G------------------------------------ 392
CACNA1D 467 P----T------------------------------------ 468
CACNA1F 444 TNRRRGR----------------------------------- 450
CACNA1A 427 K----------------------------------------- 427
CACNA1B 423 K----------------------------------------- 423
CACNA1E 416 K----------------------------------------- 416
CACNA1G 598 P----PETLKEKALVEVAASS-------G--------PPTLT 620
CACNA1H 621 V----GSGKGSTSPGPKGKWA-------G--------GPPGT 643
CACNA1I 563 R----PSGLGSTDSGQEGSGS-------G------------- 580
SCN5A 594 T----V------------DCNGVVSLLGAGDPEAT-SPGSHL 618
SCN1A 636 P----A----NGKMHSTVDCNGVVSLVGG-PSVPT-SPVGQL 667
SCN2A 639 P----M----NGKMHSAVDCNGVVSLVGG-PSTLT-SA-GQL 669
SCN3A 639 P----A----NGKMHSTVDCNGVVSLVGG-PSALT-SPTGQL 670
SCN4A 500 P----A----HGK-----DCNGSLDTSQG------------- 515
SCN7A 435 ------------------------------------------ 434
SCN8A 634 R----R----SVKRNSTVDCNGVVSLIGG-PGSHI---GGRL 663
SCN9A 613 P----V----NGKMHSAVDCNGVVSLVDG-RSALM-LPNGQL 644
SCN10A 562 -------------------------SRHG-EDEHQPPPT-SE 576
SCN11A 487 ------------------DCQKKPQLLEQ------------- 497
cons 799 840
CACNA1C 469 -------SE--------------------------------- 470
CACNA1S 393 -------SD--------------------------------- 394
CACNA1D 469 -------SE--------------------------------- 470
CACNA1F 451 -LRWF--SH--------------------------------- 456
CACNA1A 428 --K----SK--------------------------------- 430
CACNA1B 424 --K----SR--------------------------------- 426
CACNA1E 417 --R----SR--------------------------------- 419
CACNA1G 621 SL-----N----IPPGPYSSMHKLLETQSTGACQS-----SC 648
CACNA1H 644 GGH----GPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSV 681
CACNA1I 581 ------------------------------------------ 580
SCN5A 619 -LRPVMLEH------PP--DTT---TPSEEPGGPQ-----ML 643
SCN1A 668 -LPEVIIDK------PATDDNG---TTTETEMRKR-----RS 694
SCN2A 670 -LPE-----------------G---TTTETEIRKR-----RS 685
SCN3A 671 -PPE-----------------G---TTTETEVRKR-----RL 686
SCN4A 516 ------------------------------------------ 515
SCN7A 435 ----------------------------QIEMKKR-----SP 443
SCN8A 664 -LPE-----------------A----TTEVEIKKK-----GP 678
SCN9A 645 -LPE-----------------G---TTNQIH-KKR-----RC 659
SCN10A 577 -LAP---------------GAV---DVSAFD---A-----GQ 591
SCN11A 498 --T-----------------------------KRL-----SQ 503
cons 841 882
CACNA1C 471 ------TESVNTENVAG-G-DIEGEN-CG------------- 490
CACNA1S 395 ------TESLY-EI---------------------------A 402
CACNA1D 471 ------TESVNTENVSG-EGENRG-C-CGSLWCWWRRRGA-A 502
CACNA1F 457 ------STRS-THSTSSHASLP-A-SDTGSMTETQGDEDE-E 488
CACNA1A 431 ------TDLLNPEEAED-QLADIA-S-VG------------- 450
CACNA1B 427 ------NDLIHAEEGED-RFADLC-A-VG------------- 446
CACNA1E 420 ------TEAMTRDSSDE-HCVDIS-S-VG------------- 439
CACNA1G 649 KISSPCLKADSGACGPD-SCPYCA-R-AG--AG-EVELADRE 684
CACNA1H 682 PCPLPSPPAGTLTCELK-SCPYCT-R-AL--EDPEGELSGSE 718
CACNA1I 581 -SSAGGEDEADGDGARS-SEDGAS-S-EL------------- 605
SCN5A 644 TSQAPCVDGFEEPGARQ-RALSAV-S-VL--TSA-LEELE-E 678
SCN1A 695 SSFHVSMDFLEDPSQRQ-RAMSIA-S-IL--TNT-VEELE-E 729
SCN2A 686 SSYHVSMDLLEDPTSRQ-RAMSIA-S-IL--TNT-MEELE-E 720
SCN3A 687 SSYQISMEMLEDSSGRQ-RAVSIA-S-IL--TNT-MEELE-E 721
SCN4A 516 --------E---KGAPR-QSSSGD-S-GI--SDA-MEELE-E 539
SCN7A 444 ISTDTSLDVLEDATLRH-K-----------------EELE-K 466
SCN8A 679 GSLLVSMDQLASYGRKD-RINSIM-S-VV--TNTLVEELE-E 714
SCN9A 660 SSYLLSEDMLNDPNLRQ-RAMSRA-S-IL--TNT-VEELE-E 694
SCN10A 592 KKTFLSAEYLDEPFRAQ-RAMSVV-S-II--TSV-LEELE-E 626
SCN11A 504 NLSLDHFDEHGDPLQRQ-RALSAV-S-IL--TIT-MKEQE-K 538
cons 883 924
CACNA1C 491 ---------------------------A-------------- 491
CACNA1S 403 G----------------------------------------- 403
CACNA1D 503 KAG--------------------PSGCR-------------- 510
CACNA1F 489 EGA--------------------LASCT-------------- 496
CACNA1A 451 --S--------------------P--FA-------------- 454
CACNA1B 447 --S--------------------P--FA-------------- 450
CACNA1E 440 --T--------------------P--LA-------------- 443
CACNA1G 685 MPDSDSEAVYEFTQDAQHSDLRDP-HSR-------------- 711
CACNA1H 719 SGDSDGRGVYEFTQDVRHGDRWDP-TRPPRATDTPGPGPGSP 759
CACNA1I 606 ------------GKEEEE------------------------ 611
SCN5A 679 SRH--------------------K--CP-------------- 684
SCN1A 730 SRQ--------------------K--CP-------------- 735
SCN2A 721 SRQ--------------------K--CP-------------- 726
SCN3A 722 SRQ--------------------K--CP-------------- 727
SCN4A 540 AHQ--------------------K--CP-------------- 545
SCN7A 467 SKK--------------------I--CP-------------- 472
SCN8A 715 SQR--------------------K--CP-------------- 720
SCN9A 695 SRQ--------------------K--CP-------------- 700
SCN10A 627 SEQ--------------------K--CP-------------- 632
SCN11A 539 SQE--------------------P--CL-------------- 544
cons 925 966
CACNA1C 492 --RLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVI 531
CACNA1S 404 ----LNKI--IQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVI 439
CACNA1D 511 --RWGQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVI 550
CACNA1F 497 --RCLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVL 536
CACNA1A 455 --RASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVL 494
CACNA1B 451 --RASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVL 490
CACNA1E 444 --RASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIVL 483
CACNA1G 712 --RQ-RSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIM 750
CACNA1H 760 QRRAQQRAAPGE-PGWMGRLWVTFSGKLRRIVDSKYFSRGIM 800
CACNA1I 612 -----EEQADGA-VWLCGDVWRETRAKLRGIVDSKYFNRGIM 647
SCN5A 685 --PCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTIT 724
SCN1A 736 --PCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAIT 775
SCN2A 727 --PCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAIT 766
SCN3A 728 --PCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAIT 767
SCN4A 546 --PWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGIT 585
SCN7A 473 --LYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLI 512
SCN8A 721 --PCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAIT 760
SCN9A 701 --PWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAIT 740
SCN10A 633 --PCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTIT 672
SCN11A 545 --PCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAIT 584
cons 967 : : 1008
CACNA1C 532 FLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLL 573
CACNA1S 440 LIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLM 481
CACNA1D 551 VLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLV 592
CACNA1F 537 LLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLL 578
CACNA1A 495 SLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFI 536
CACNA1B 491 CVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSL 532
CACNA1E 484 SLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSL 525
CACNA1G 751 IAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLL 792
CACNA1H 801 MAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLL 842
CACNA1I 648 MAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMIL 689
SCN5A 725 MCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTF 766
SCN1A 776 ICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFL 817
SCN2A 767 ICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFL 808
SCN3A 768 ICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVL 809
SCN4A 586 ICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVL 627
SCN7A 513 ICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIF 554
SCN8A 761 ICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFL 802
SCN9A 741 ICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVL 782
SCN10A 673 LCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVF 714
SCN11A 585 ICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCL 626
cons 1009 : :*. : :: : : :* ** . 1050
CACNA1C 574 KMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLG 615
CACNA1S 482 KMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLG 523
CACNA1D 593 KMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLG 634
CACNA1F 579 KLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLG 620
CACNA1A 537 KMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFG 578
CACNA1B 533 KMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFG 574
CACNA1E 526 KMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFG 567
CACNA1G 793 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGG-----G 829
CACNA1H 843 KLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADG-----G 879
CACNA1I 690 KLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADG-----G 726
SCN5A 767 KIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMS-----N 803
SCN1A 818 KIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVE-----G 854
SCN2A 809 KIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVE-----G 845
SCN3A 810 KIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVE-----G 846
SCN4A 628 KLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQ-----G 664
SCN7A 555 KIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVA-----G 591
SCN8A 803 KLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVE-----G 839
SCN9A 783 KLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVE-----G 819
SCN10A 715 KIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKG-----S 751
SCN11A 627 KIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKR---S 665
cons 1051 *: *. :* ** : .. : . 1092
CACNA1C 616 ISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLL 657
CACNA1S 524 ISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLL 565
CACNA1D 635 ISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLL 676
CACNA1F 621 ISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLL 662
CACNA1A 579 ISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFL 620
CACNA1B 575 ISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFL 616
CACNA1E 568 ISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFL 609
CACNA1G 830 LSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCML 871
CACNA1H 880 LSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTL 921
CACNA1I 727 LSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCML 768
SCN5A 804 LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845
SCN1A 855 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLV 896
SCN2A 846 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLV 887
SCN3A 847 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLV 888
SCN4A 665 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLV 706
SCN7A 592 MALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLL 633
SCN8A 840 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLV 881
SCN9A 820 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLV 861
SCN10A 752 LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTII 793
SCN11A 666 WPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVV 707
cons 1093 ..:* .*::*::*: : :: : : .: : : : 1134
CACNA1C 658 LFLFIIIFSLLGMQLFGGKFNFD-E------------MQTRR 686
CACNA1S 566 LFLFIVIFALLGMQLFGGRYDFE-D------------TEVRR 594
CACNA1D 677 LFLFIIIFSLLGMQLFGGKFNFD-E------------TQTKR 705
CACNA1F 663 LFLFIIIFSLLGMQLFGGKFNFD-Q------------THTKR 691
CACNA1A 621 LFLFIVVFALLGMQLFGGQFNFD-E------------GT-PP 648
CACNA1B 617 LFLFIVVFALLGMQLFGGQFNFQ-D------------ET-PT 644
CACNA1E 610 LFLFIVVFALLGMQLFGGRFNFN-D------------GT-PS 637
CACNA1G 872 LMLFIFIFSILGMHLFGCKFASER---------DG-DTLPDR 903
CACNA1H 922 LMLFIFIFSILGMHLFGCKFSLKTD--------TG-DTVPDR 954
CACNA1I 769 LMLFIFIFSILGMHIFGCKFSLRTD--------TG-DTVPDR 801
SCN5A 846 LAIIVFIFAVVGMQLFGKNYSEL-RDS-------D-SGLLPR 878
SCN1A 897 LAIIVFIFAVVGMQLFGKSYKDC-VCK----I-AS-DCQLPR 931
SCN2A 888 LAIIVFIFAVVGMQLFGKSYKEC-VCK----I-SN-DCELPR 922
SCN3A 889 LAIIVFIFAVVGMQLFGKSYKEC-VCK----I-ND-DCTLPR 923
SCN4A 707 LAIIVFIFAVVGMQLFGKSYKEC-VCK----I-AL-DCNLPR 741
SCN7A 634 LFTFIFFSAAFGMKLFGKNYEEF-VCH----I-DK-DCQLPR 668
SCN8A 882 LAIIVFIFAVVGMQLFGKSYKEC-VCK----I-NQ-DCELPR 916
SCN9A 862 LAIIVFIFAVVGMQLFGKSYKEC-VCK----I-ND-DCTLPR 896
SCN10A 794 LAIIVFVFALVGKQLLGENYRNN-RKN----I-SAPHEDWPR 829
SCN11A 708 LVIVIFIFSVVGMQLFGRSFNSQ-KSPKLCNPTGPTVSCLRH 748
cons 1135 * .:.. : .* :::* : 1176
CACNA1C 687 STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAY-GGPSFPGM 727
CACNA1S 595 SNFDNFPQALISVFQVLTGEDWTSMMYNGIMAY-GGPSYPGM 635
CACNA1D 706 STFDNFPQALLTVFQILTGEDWNAVMYDGIMAY-GGPSSSGM 746
CACNA1F 692 STFDTFPQALLTVFQILTGEDWNVVMYDGIMAY-GGPFFPGM 732
CACNA1A 649 TNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQ-GGV-QGGM 688
CACNA1B 645 TNFDTFPAAILTVFQILTGEDWNAVMYHGIESQ-GGV-SKGM 684
CACNA1E 638 ANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQ-GGV-SSGM 677
CACNA1G 904 KNFDSLLWAIVTVFQILTQEDWNKVLYNGMAS--T-S----S 938
CACNA1H 955 KNFDSLLWAIVTVFQILTQEDWNVVLYNGMAS--T-S----S 989
CACNA1I 802 KNFDSLLWAIVTVFQILTQEDWNVVLYNGMAS--T-S----P 836
SCN5A 879 WHMMDFFHAFLIIFRILCGE-WIETMWDCMEV--SGQ----S 913
SCN1A 932 WHMNDFFHSFLIVFRVLCGE-WIETMWDCMEV--AGQ----A 966
SCN2A 923 WHMHDFFHSFLIVFRVLCGE-WIETMWDCMEV--AGQ----T 957
SCN3A 924 WHMNDFFHSFLIVFRVLCGE-WIETMWDCMEV--AGQ----T 958
SCN4A 742 WHMHDFFHSFLIVFRILCGE-WIETMWDCMEV--AGQ----A 776
SCN7A 669 WHMHDFFHSFLNVFRILCGE-WVETLWDCMEV--AGQ----S 703
SCN8A 917 WHMHDFFHSFLIVFRVLCGE-WIETMWDCMEV--AGQ----A 951
SCN9A 897 WHMNDFFHSFLIVFRVLCGE-WIETMWDCMEV--AGQ----A 931
SCN10A 830 WHMHDFFHSFLIVFRILCGE-WIENMWACMEV--GQK----S 864
SCN11A 749 WHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASS----S 785
cons 1177 : : ::: :*::* * * :: : 1218
CACNA1C 728 LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769
CACNA1S 636 LVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAK 677
CACNA1D 747 IVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEE 788
CACNA1F 733 LVCIYFIILFICGNYILLNVFLAIAVDNLASGDA-GTAKDKG 773
CACNA1A 689 VFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 730
CACNA1B 685 FSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEM 726
CACNA1E 678 WSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 719
CACNA1G 939 WAALYFIALMTFGNYVLFNLLVAILVEGFQ-AEEISKREDAS 979
CACNA1H 990 WAALYFVALMTFGNYVLFNLLVAILVEGFQ-AEGDANRSDTD 1030
CACNA1I 837 WASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDE 878
SCN5A 914 LCLLVFLLVMVIGNLVVLNLFLALLLSSFS-ADNLTAP-DED 953
SCN1A 967 MCLTVFMMVMVIGNLVVLNLFLALLLSSFS-ADNLAAT-DDD 1006
SCN2A 958 MCLTVFMMVMVIGNLVVLNLFLALLLSSFS-SDNLAAT-DDD 997
SCN3A 959 MCLIVFMLVMVIGNLVVLNLFLALLLSSFS-SDNLAAT-DDD 998
SCN4A 777 MCLTVFLMVMVIGNLVVLNLFLALLLSSFS-ADSLAAS-DED 816
SCN7A 704 WCIPFYLMVILIGNLLVLYLFLA-LVSSFS-SCKDVTA-EEN 742
SCN8A 952 MCLIVFMMVMVIGNLVVLNLFLALLLSSFS-ADNLAAT-DDD 991
SCN9A 932 MCLIVYMMVMVIGNLVVLNLFLALLLSSFS-SDNLTAI-EED 971
SCN10A 865 ICLILFLTVMVLGNLVVLNLFIALLLNSFS-ADNLTAP-EDD 904
SCN11A 786 LCVIVFILITVIGKLVVLNLFIALLLNSFS-NEERNGNLEGE 826
cons 1219 :: : *: :: :::* :..: . 1260
CACNA1C 770 EEE-KERK-K----LAR---TASPEKKQE------------- 789
CACNA1S 678 AEE-KKRR-K----MSKGLPDKSEEEK-S------------- 699
CACNA1D 789 AEE-KERK-K----IAR---KESLENK--------------- 806
CACNA1F 774 GEK-SNEKDL----PQE---NEGLVPG--------------- 792
CACNA1A 731 EEA-ANQK-L-ALQKAKEVAEVSPLSAANMSIAVKEQQKNQK 769
CACNA1B 727 EEA-ANQK-L-ALQKAKEVAEVSPMSAANISIAA--RQQNSA 763
CACNA1E 720 EEA-FNQK-H-ALQKAKEVSPMSAPNMPSIE--R---DRRRR 753
CACNA1G 980 GQL-SCIQ-L-PVDSQ---------------------GGDAN 997
CACNA1H 1031 EDKTSVHF-EEDFHKL-------------------------- 1045
CACNA1I 879 DQS-SSNI-E-EFDKL-------------------------- 891
SCN5A 954 REM-NNLQ-L-ALARIQ--------------------RGLRF 972
SCN1A 1007 NEM-NNLQ-I-AVDRMH--------------------KGVAY 1025
SCN2A 998 NEM-NNLQ-I-AVGRMQ--------------------KGIDF 1016
SCN3A 999 NEM-NNLQ-I-AVGRMQ--------------------KGIDY 1017
SCN4A 817 GEM-NNLQ-I-AIGRIK--------------------LGIGF 835
SCN7A 743 NEA-KNLQ-L-AVARIK--------------------KGINY 761
SCN8A 992 GEM-NNLQ-I-SVIRIK--------------------KGVAW 1010
SCN9A 972 PDA-NNLQ-I-AVTRIK--------------------KGINY 990
SCN10A 905 GEV-NNLQ-V-ALARIQ--------------------VFGHR 923
SCN11A 827 ARK-TKVQ-L-ALDRFR--------------------RAFCF 845
cons 1261 1302
CACNA1C 790 --------LVE----------KPA-V---GE-S--------K 800
CACNA1S 700 ------------------------------------------ 699
CACNA1D 807 -----------------------------------------K 807
CACNA1F 793 ------------------------------------------ 792
CACNA1A 770 PAKSVWEQRTSEMRKQNLLASREA-L--YNEMDPDERW---K 805
CACNA1B 764 KARSVWEQRASQLRLQNLRASCEA-L--YSEMDPEERL---R 799
CACNA1E 754 HHMSMWEPRSSHLRERR---RRHH-M---SV-WEQRTS---- 783
CACNA1G 998 KSESEPDFFSPSLDGDGDRKKCLA-LVSLGEHPELRKS---L 1035
CACNA1H 1046 ---------REL--QTTELKMCSL-AVTPNGHLEGRGS---L 1072
CACNA1I 892 ---------QEGLDSSGDPKLCPI-PMTPNGHLDPSLP---L 920
SCN5A 973 VKRTTWDFCCGLLRQ--RPQKP-AALA---AQGQLPSCIATP 1008
SCN1A 1026 VKRKIYEFIQQSFIR--KQKIL-DEIK---PLDDLNN---KK 1058
SCN2A 1017 VKRKIREFIQKAFVR--KQKAL-DEIK---PLEDLNN---KK 1049
SCN3A 1018 VKNKMRECFQKAFFR--KPKVI-E-IH---E----GN---KI 1045
SCN4A 836 AKAFLLGLLHGKILS--PKDIM-LSLG---EADGAGE---AG 868
SCN7A 762 VLLKILCKTQNVP----K-----DTMD---HVNEVYV---KE 788
SCN8A 1011 TKLKVHAFMQAHF-K--QR-EA-DEVK---PLDELYE---KK 1041
SCN9A 991 VKQTLREFILKAFSK--KPKIS-REIR---QAEDLNT---KK 1023
SCN10A 924 TKQALCSFFSRSCPFP-QPKAE-PELVV--KLPLSSS---KA 958
SCN11A 846 VRHTLEHFCHKWC-R--KQNLP-----------QQKEV---A 870
cons 1303 1344
CACNA1C 801 EE-------KI---ELKS---------ITADG---------- 813
CACNA1S 700 TM-------AK---KLEQ---------K-PKG---------- 711
CACNA1D 808 NN-------KP---EVNQ---------I-ANS---------- 819
CACNA1F 793 VE-------KE---EEE------------------------- 799
CACNA1A 806 AA-----YTRHLRPDMKTHLDRPLVVDPQENRNNNTNKSRAA 842
CACNA1B 800 FA-----TTRHLRPDMKTHLDRPLVVELGRDGARGPVGGKAR 836
CACNA1E 784 -Q-----LRKHMQMSSQEALNR---EEAPTMNPLNPLNPLSS 816
CACNA1G 1036 LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEP 1077
CACNA1H 1073 SPPLIMCTAATPM-PTPKSSPFLDAAPSLPDSRRGSSSSGDP 1113
CACNA1I 921 GGHLGPAGAAGPA---PRLSLQPDPMLVALGSRKSSVMSLGR 959
SCN5A 1009 YS-----PPPP------ETE-KVPPTRKETRFEEGEQPGQGT 1038
SCN1A 1059 DS-----CMSN------HT-AEIGKDLDYLKDVNGTTSGIGT 1088
SCN2A 1050 DS-----CISN------HTTIEIGKDLNYLKDGNGTTSGI-- 1078
SCN3A 1046 DS-----CMSN------NTGIEISKELNYLRDGNGTTSGVGT 1076
SCN4A 869 EA-----GETA------PEDEKKEPPEEDLKKDNHILNHMG- 898
SCN7A 789 D-------ISD------HTLSELSNTQDFLKDKEKSS----- 812
SCN8A 1042 AN-----CIAN------HTGADIHRNGDFQKNGNGTTSGI-- 1070
SCN9A 1024 EN-----YISN------HTLAEMSKGHNFLKEKD-KISGF-- 1051
SCN10A 959 EN-----HIAA------NTA-------------RGSSGGLQ- 975
SCN11A 871 GG-----CAAQ--------SKDIIPLVMEMKRGSETQEELGI 899
cons 1345 1386
CACNA1C 814 ---E-----S-----PPATK--INMD-D-------------- 825
CACNA1S 712 ---E-----GI----PTTAK--LKID-E-------------- 724
CACNA1D 820 ---D--------------NK--VTID-D-------------- 827
CACNA1F 800 ------------------------------------------ 799
CACNA1A 843 EPTVD-QRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRP 883
CACNA1B 837 PEAAE-APEG----VDPPRRHHRHRDKDKTPAAGDQDRAEAP 873
CACNA1E 817 LNPLN-AHPS------LYRRPRAIEGLALGLALEKFEEERIS 851
CACNA1G 1078 GAAHEMKS--P-----PSAR--SS------------PHSPWS 1098
CACNA1H 1114 PLGD-QKP--P-----ASLR--SS------------PCAPWG 1133
CACNA1I 960 MSYD-QRS--L-----SSSR--SS------------YYGPWG 979
SCN5A 1039 ----------------PGDPE--------------------- 1043
SCN1A 1089 ----------------GSSVEKYIID---------------- 1098
SCN2A 1079 ----------------GSSVEKYVVD---------------- 1088
SCN3A 1077 ----------------GSSVEKYVID---------------- 1086
SCN4A 899 -----------------LADGPPSSL---------------- 907
SCN7A 813 ------------------GTEKNA-T---------------- 819
SCN8A 1071 ----------------GSSVEKYIID---------------- 1080
SCN9A 1052 ----------------GSSVDKHLME---------------- 1061
SCN10A 976 ---------------------APRGP---------------- 980
SCN11A 900 ----------------LTSVPKTLGV---------------- 909
cons 1387 1428
CACNA1C 826 ------------------------------------------ 825
CACNA1S 725 ------------------------------------------ 724
CACNA1D 828 ------------------------------------------ 827
CACNA1F 800 ------------------------------------------ 799
CACNA1A 884 WAGSQEAELSREDPYGRESDHHAREGSLEQPGFWEGEAERGK 925
CACNA1B 874 KAESG------EPGAREERPRPHRSHSKEAAGPPEARSERGR 909
CACNA1E 852 RGGSLKGDGGDRSSALDNQRTPLSLGQREPP--WLARP---- 887
CACNA1G 1099 AASSWTSR---------------------------------- 1106
CACNA1H 1134 PSGAWSSR---------------------------------- 1141
CACNA1I 980 RSAAWASR---------------------------------- 987
SCN5A 1044 ------------------------------------------ 1043
SCN1A 1099 ------------------------------------------ 1098
SCN2A 1089 ------------------------------------------ 1088
SCN3A 1087 ------------------------------------------ 1086
SCN4A 908 ------------------------------------------ 907
SCN7A 820 ------------------------------------------ 819
SCN8A 1081 ------------------------------------------ 1080
SCN9A 1062 ------------------------------------------ 1061
SCN10A 981 ------------------------------------------ 980
SCN11A 910 ------------------------------------------ 909
cons 1429 1470
CACNA1C 826 ------------------------------------------ 825
CACNA1S 725 ------------------------------------------ 724
CACNA1D 828 ------------------------------------------ 827
CACNA1F 800 ------------------------------------------ 799
CACNA1A 926 AGDPHRRHV---HRQGGSRESRSGSPRTGADGEHRRHRAHRR 964
CACNA1B 910 GPGPE----------GGRRHHRRGSPEEAAEREPRRHRAHRH 941
CACNA1E 888 ---CHGNCDPTQQEAGGGEAVVTFEDRARHRQSQRRSR-HRR 925
CACNA1G 1107 ------------------------------------------ 1106
CACNA1H 1142 ------------------------------------------ 1141
CACNA1I 988 ------------------------------------------ 987
SCN5A 1044 ------------------------------------------ 1043
SCN1A 1099 ------------------------------------------ 1098
SCN2A 1089 ------------------------------------------ 1088
SCN3A 1087 ------------------------------------------ 1086
SCN4A 908 ------------------------------------------ 907
SCN7A 820 ------------------------------------------ 819
SCN8A 1081 ------------------------------------------ 1080
SCN9A 1062 ------------------------------------------ 1061
SCN10A 981 ------------------------------------------ 980
SCN11A 910 ------------------------------------------ 909
cons 1471 1512
CACNA1C 826 ------------------------------------------ 825
CACNA1S 725 ------------------------------------------ 724
CACNA1D 828 ------------------------------------------ 827
CACNA1F 800 ------------------------------------------ 799
CACNA1A 965 --PGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRR 1004
CACNA1B 942 QDPSKECAGAKGERRARHRGG---PRAGPREAESGEEPARRH 980
CACNA1E 926 --VRTEGKESSSASRSRSASQERSLDE-AMPTEGEKDHELRG 964
CACNA1G 1107 --------------R--------------------------- 1107
CACNA1H 1142 --------------R--------------------------- 1142
CACNA1I 988 --------------R--------------------------- 988
SCN5A 1044 ------------------------------------------ 1043
SCN1A 1099 --------------E--------------------------- 1099
SCN2A 1089 --------------E--------------------------- 1089
SCN3A 1087 --------------E--------------------------- 1087
SCN4A 908 --------------E--------------------------- 908
SCN7A 820 --------------E--------------------------- 820
SCN8A 1081 --------------E--------------------------- 1081
SCN9A 1062 --------------D--------------------------- 1062
SCN10A 981 --------------R--------------------------- 981
SCN11A 910 --------------R--------------------------- 910
cons 1513 1554
CACNA1C 826 ----------------------------LQPNENEDKSPYPN 839
CACNA1S 725 ----------------------------FESNVNEVKDPYPS 738
CACNA1D 828 ----------------------------YR-EEDEDKDPYPP 840
CACNA1F 800 ------------------------------------GARREG 805
CACNA1A 1005 RHRHGAPATYEGDARREDKERRHRRRKENQGSGVPVSGPNLS 1046
CACNA1B 981 RARH-------------------------------------- 984
CACNA1E 965 NHGA--KEPTIQEERAQDL-RRTNSLMVSRGSG--------- 994
CACNA1G 1108 ----------------------------SS-RNSLGRAPSLK 1120
CACNA1H 1143 ----------------------------SS-WSSLGRAPSLK 1155
CACNA1I 989 ----------------------------SS-WNSLKHKP--- 998
SCN5A 1044 -----------------------------------------P 1044
SCN1A 1100 ----------------------------SD-YMSFINNPSLT 1112
SCN2A 1090 ----------------------------SD-YMSFINNPSLT 1102
SCN3A 1088 ----------------------------ND-YMSFINNPSLT 1100
SCN4A 909 ----------------------------LD-HLNFINNPYLT 921
SCN7A 821 ----------------------------NE-SQSLIPSPSVS 833
SCN8A 1082 -----------------------------D-HMSFINNPNLT 1093
SCN9A 1063 ----------------------------SD-GQSFIHNPSLT 1075
SCN10A 982 ----------------------------DE-HSDFIANPTVW 994
SCN11A 911 ----------------------------HD-W---------T 914
cons 1555 1596
CACNA1C 840 PE-------------TTGEEDEE------------------- 849
CACNA1S 739 AD-------------FPGDDEED------------------- 748
CACNA1D 841 CDVPVGE--------EEEEEEED------------------- 855
CACNA1F 806 ADMEEEE--------EEEEEEEE------------------- 820
CACNA1A 1047 TTRPIQQDLGRQDPPLAEDIDNMKN-NK--LA---------- 1075
CACNA1B 985 ------------------------------KA---------- 986
CACNA1E 995 ----LAGGLDEADTPLVLPHPELEV-GK--HV---------- 1019
CACNA1G 1121 RRSPSGERR--------SLLSGEGQE---SQDEEESSEE--E 1149
CACNA1H 1156 RRGQCGERE--------SLLSGEGKG---STDDE--AEDGRA 1184
CACNA1I 999 ---PSAEHE--------SLLSAERGGGARVCE----VA--AD 1023
SCN5A 1045 VCVPIAVAE--------SDTDDQEED---------------- 1062
SCN1A 1113 VTVPIAVGE--------SDFENLNTE---------------- 1130
SCN2A 1103 VTVPIAVGE--------SDFENLNTE---------------- 1120
SCN3A 1101 VTVPIAVGE--------SDFENLNTE---------------- 1118
SCN4A 922 IQVPIASEE--------SDLEMPTEE---------------- 939
SCN7A 834 ETVPIASGE--------SDIENLDNK---------------- 851
SCN8A 1094 VRVPIAVGE--------SDFENLNTE---------------- 1111
SCN9A 1076 VTVPIAPGE--------SDLENMNAE---------------- 1093
SCN10A 995 VSVPIAEGE--------SDLDDLEDDGGEDAQ----SF--QQ 1022
SCN11A 915 WLAPLAEEE--------DDVEFSGED---------------- 932
cons 1597 1638
CACNA1C 850 -------------------EPEMP------------------ 854
CACNA1S 749 -------------------EPEIP------------------ 753
CACNA1D 856 -------------------EPEVP------------------ 860
CACNA1F 821 -------------------EEEEE------------------ 825
CACNA1A 1076 --------------TAESAAPHGSLGHAGL---PQSPAKMGN 1100
CACNA1B 987 --------------QPAHEAVEKETTEKEA---TEKEAEIVE 1011
CACNA1E 1020 --------------VLTEQEPEGSSEQALL---GNVQLDMGR 1044
CACNA1G 1150 RAS----PAGSDHR---------------HRGSL--EREAKS 1170
CACNA1H 1185 APG----PRATPLR-----------------RA--------- 1196
CACNA1I 1024 EGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTL--SLDNRD 1063
SCN5A 1063 ------------------------------------------ 1062
SCN1A 1131 ------------------------------------------ 1130
SCN2A 1121 ------------------------------------------ 1120
SCN3A 1119 ------------------------------------------ 1118
SCN4A 940 ------------------------------------------ 939
SCN7A 852 ------------------------------------------ 851
SCN8A 1112 ------------------------------------------ 1111
SCN9A 1094 ------------------------------------------ 1093
SCN10A 1023 EVIPKGQQEQLQQV---ERCGDHLTPR---SPGTGTSSEDLA 1058
SCN11A 933 ------------------------------------------ 932
cons 1639 1680
CACNA1C 855 ---VGP------------------------------------ 857
CACNA1S 754 ---LSP------------------------------------ 756
CACNA1D 861 ---AGP------------------------------------ 863
CACNA1F 826 ---GAG------------------------------------ 828
CACNA1A 1101 STDPGPMLAIP--AMATNP--------QNAASRRTPNNPGNP 1132
CACNA1B 1012 ADKEKELR-NH--QPREPHCDLETSGTVTVGPMHTLPST--- 1047
CACNA1E 1045 VIS--------------------------------------- 1047
CACNA1G 1171 SFDLPDT--LQ--VPG-------------------------- 1182
CACNA1H 1197 --------------ES-------------------------- 1198
CACNA1I 1064 SVDLAEL--VP--AVG-------------------------- 1075
SCN5A 1063 -----EEN--SLGTEEESSKQQESQPVSGGPEAPPDSRTWSQ 1097
SCN1A 1131 -----DFS--SESDLEESK----------------------- 1142
SCN2A 1121 -----EFS--SESDMEESK----------------------- 1132
SCN3A 1119 -----EFS--SESELEESK----------------------- 1130
SCN4A 940 -----ETD--TFSEPEDSKKP--------------------- 953
SCN7A 852 -----EIQ--SKSGDGGSK----------------------- 863
SCN8A 1112 -----DVS--SESDPEGSK----------------------- 1123
SCN9A 1094 -----ELS--SDSDSEYSK----------------------- 1105
SCN10A 1059 PSLGETWK--DESVPQVPA----------------------- 1075
SCN11A 933 -----NAQ--RITQPEPEQQAYEL------------------ 949
cons 1681 1722
CACNA1C 858 -----R------------------------------------ 858
CACNA1S 757 -----R------------------------------------ 757
CACNA1D 864 -----R------------------------------------ 864
CACNA1F 829 -----G------------------------------------ 829
CACNA1A 1133 SNPGPP-----------------KTPENSLIVTNPSGTQ--- 1154
CACNA1B 1048 ---C-------------------LQK----VEEQPEDADNQR 1063
CACNA1E 1048 -----------------------QSE------PDLSC----- 1055
CACNA1G 1183 ------------------------LH---------------- 1184
CACNA1H 1199 ------------------------LD---------------- 1200
CACNA1I 1076 ------------------------AH---------------- 1077
SCN5A 1098 VSATASSEAEASASQADW----RQQW---------------- 1119
SCN1A 1143 ------------------------------------------ 1142
SCN2A 1133 ------------------------------------------ 1132
SCN3A 1131 ------------------------------------------ 1130
SCN4A 954 ------------------------------------------ 953
SCN7A 864 ------------------------------------------ 863
SCN8A 1124 ------------------------------------------ 1123
SCN9A 1106 ------------------------------------------ 1105
SCN10A 1076 ------------------------------------------ 1075
SCN11A 950 -HQENKKPTSQRVQSVEIDMFSEDEP---------------- 974
cons 1723 1764
CACNA1C 859 -------------------------PRPLSE----------- 864
CACNA1S 758 -------------------------PRPLAE----------- 763
CACNA1D 865 -------------------------PRRISE----------- 870
CACNA1F 830 -------------------------VELLQE----------- 835
CACNA1A 1155 -TNS--A-KTARKPDHTTVDIPPACPPPLNHTVVQVNKNANP 1192
CACNA1B 1064 NVTR--M-GSQPPDPNTIV----HIPVMLTGPLGEATVVPSG 1098
CACNA1E 1056 -ITANTD-KATTESTSVTVAIPDVDPLVDSTVVHISNKTDGE 1095
CACNA1G 1185 ------R-TASG--RGSASEHQDCNGKSASGRLARALRPDDP 1217
CACNA1H 1201 ------P-RPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSH 1235
CACNA1I 1078 ------P-RAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGD- 1111
SCN5A 1120 ------KAEPQAPGCG---ETPE-DSCSEGSTADMTNTAEL- 1150
SCN1A 1143 --------------E----KLNESSSSSEGSTVDIGAPVE-- 1164
SCN2A 1133 --------------E----KLNA-TSSSEGSTVDIGAPAEG- 1154
SCN3A 1131 --------------E----KLNA-TSSSEGSTVDVVLPREG- 1152
SCN4A 954 -------------PQ----PLYD-GNSSVCSTADYKPPEED- 976
SCN7A 864 --------------E----KIKQ-SSSSECSTVDIAISEEE- 885
SCN8A 1124 --------------D----KLDD-TSSSEGSTIDIKPEVE-- 1144
SCN9A 1106 --------------V----RLNR-SSSSECSTVDNPLPGEG- 1127
SCN10A 1076 --------------E----GVDD-TSSSEGSTVDCLDPEEI- 1097
SCN11A 975 ------HLTIQDPRK----KSDVTSILSECSTIDLQDGFG-- 1004
cons 1765 1806
CACNA1C 865 ------------------------------LHLKEKAVPMPE 876
CACNA1S 764 ------------------------------LQLKEKAVPIPE 775
CACNA1D 871 ------------------------------LNMKEKIAPIPE 882
CACNA1F 836 ------------------------------VVPKEKVVPIPE 847
CACNA1A 1193 DPLPKKEEEKKEEEEE-DDR------------GEDGPKPMPP 1221
CACNA1B 1099 NVDLESQAEGKKEVEA-DDV------------MRSGPRPIVP 1127
CACNA1E 1096 ASPLKEA-EIREDEEEVEKK------K-QKKEKRETGKAMVP 1129
CACNA1G 1218 PLDG-----DDADDEG-NLSKGERVRAWIRAR-LPACCLERD 1252
CACNA1H 1236 REDA-----AELDDDS-EDSCCLRLHKVLEPY-KPQWCRSRE 1270
CACNA1I 1112 RGDR-----GEDEEEI-DYTLCFRVRKMIDVY-KPDWCEVRE 1146
SCN5A 1151 LEQIPDL--GQDVKDP-EDC------------FTEGCVRRCP 1177
SCN1A 1165 -EQPVVE--PEETLEP-EAC------------FTEGCVQRFK 1190
SCN2A 1155 -EQPEVE--PEESLEP-EAC------------FTEDCVRKFK 1180
SCN3A 1153 -EQAETE--PEEDLKP-EAC------------FTEGCIKKFP 1178
SCN4A 977 PEEQAEE--NPEGEQP-EEC------------FTEACVQRWP 1003
SCN7A 886 ------E--MFYGGER-SKH------------LKNGCRRGSS 906
SCN8A 1145 -EVPVEQ--PEEYLDP-DAC------------FTEGCVQRFK 1170
SCN9A 1128 -EEAEAE--PMNSDEP-EAC------------FTDGCVWRFS 1153
SCN10A 1098 LRKIPEL--ADDLEEP-DDC------------FTEGCIRHCP 1124
SCN11A 1005 -WL--PE--MVPKKQP-ERC------------LPKGFGCCFP 1028
cons 1807 1848
CACNA1C 877 ASAFFIF----SSNNRFRLQCHRIVNDTIFTNLILFFILLSS 914
CACNA1S 776 ASSFFIF----SPTNKIRVLCHRIVNATWFTNFILLFILLSS 813
CACNA1D 883 GSAFFIL----SKTNPIRVGCHKLINHHIFTNLILVFIMLSS 920
CACNA1F 848 GSAFFCL----SQTNPLRKGCHTLIHHHVFTNLILVFIILSS 885
CACNA1A 1222 YSSMFIL----STTNPLRRLCHYILNLRYFEMCILMVIAMSS 1259
CACNA1B 1128 YSSMFCL----SPTNLLRRFCHYIVTMRYFEVVILVVIALSS 1165
CACNA1E 1130 HSSMFIF----STTNPIRRACHYIVNLRYFEMCILLVIAASS 1167
CACNA1G 1253 SWSAYIF----PPQSRFRLLCHRIITHKMFDHVVLVIIFLNC 1290
CACNA1H 1271 AWALYLF----SPQNRFRVSCQKVITHKMFDHVVLVFIFLNC 1308
CACNA1I 1147 DWSVYLF----SPENRFRVLCQTIIAHKLFDYVVLAFIFLNC 1184
SCN5A 1178 CCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSS 1219
SCN1A 1191 CCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSS 1232
SCN2A 1181 CCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSS 1222
SCN3A 1179 FCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSS 1220
SCN4A 1004 CLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSS 1045
SCN7A 907 LGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLST 948
SCN8A 1171 CCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSS 1212
SCN9A 1154 CCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSS 1195
SCN10A 1125 CCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSS 1166
SCN11A 1029 CCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLSS 1070
cons 1849 .* * :: * : . . 1890
CACNA1C 915 ISLAAEDPV-QHTSFRNHILFYFDIVFTTIFTIEIALKMTAY 955
CACNA1S 814 AALAAEDPI-RADSMRNQILKHFDIGFTSVFTVEIVLKMTTY 854
CACNA1D 921 AALAAEDPI-RSHSFRNTILGYFDYAFTAIFTVEILLKMTTF 961
CACNA1F 886 VSLAAEDPI-RAHSFRNHILGYFDYAFTSIFTVEILLKMTVF 926
CACNA1A 1260 IALAAEDPV-QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDL 1300
CACNA1B 1166 IALAAEDPV-RTDSPRNNALKYLDYIFTGVFTFEMVIKMIDL 1206
CACNA1E 1168 IALAAEDPV-LTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQ 1208
CACNA1G 1291 ITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1332
CACNA1H 1309 VTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVAL 1350
CACNA1I 1185 ITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSL 1226
SCN5A 1220 GALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 1261
SCN1A 1233 GALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAY 1274
SCN2A 1223 GALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAY 1264
SCN3A 1221 GALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAY 1262
SCN4A 1046 GALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAY 1087
SCN7A 949 GTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAY 990
SCN8A 1213 GALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAY 1254
SCN9A 1196 GALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAY 1237
SCN10A 1167 GSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAY 1208
SCN11A 1071 GALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAF 1112
cons 1891 :: * . * : ** :* *: :* 1932
CACNA1C 956 GAFLHKGSFCRNYFNILDLLVVSVSLISF-----G---IQSS 989
CACNA1S 855 GAFLHKGSFCRNYFNMLDLLVVAVSLISM-----G---LESS 888
CACNA1D 962 GAFLHKGAFCRNYFNLLDMLVVGVSLVSF-----G---IQSS 995
CACNA1F 927 GAFLHRGSFCRSWFNMLDLLVVSVSLISF-----G---IHSS 960
CACNA1A 1301 GLVLHQGAYFRDLWNILDFIVVSGALVAFAFTG-N---SKGK 1338
CACNA1B 1207 GLLLHPGAYFRDLWNILDFIVVSGALVAFAFS--G---SKGK 1243
CACNA1E 1209 GLILQDGSYFRDLWNILDFVVVVGALVAFALAN-ALGTNKGR 1249
CACNA1G 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVS-D-SGTK 1372
CACNA1H 1351 GLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMAS-A-GGAK 1390
CACNA1I 1227 GLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLAS-A-GGAK 1266
SCN5A 1262 GF----KKYFTNAWCWLDFLIVDVSLVSLVAN--T---LGFA 1294
SCN1A 1275 GY----QTYFTNAWCWLDFLIVDVSLVSLTAN--A---LGYS 1307
SCN2A 1265 GF----QVYFTNAWCWLDFLIVDVSLVSLTAN--A---LGYS 1297
SCN3A 1263 GF----QTYFTNAWCWLDFLIVDVSLVSLVAN--A---LGYS 1295
SCN4A 1088 GF----KVYFTNAWCWLDFLIVDVSIISLVAN--W---LGYS 1120
SCN7A 991 GF----KAYFSNGWYRLDFVVVIVFCLSLIGK--T---RE-- 1021
SCN8A 1255 GF----VKFFTNAWCWLDFLIVAVSLVSLIAN--A---LGYS 1287
SCN9A 1238 GY----KTYFTNAWCWLDFLIVDVSLVTLVAN--T---LGYS 1270
SCN10A 1209 GF----KKYFTNAWCWLDFLIVNISLISLTAK--I---LEYS 1241
SCN11A 1113 GF----GKYFTSAWCCLDFIIVIVSVTTLIN----------- 1139
cons 1933 * : . : ** .:* : 1974
CACNA1C 990 AINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGN 1031
CACNA1S 889 AISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGN 930
CACNA1D 996 AISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGN 1037
CACNA1F 961 AISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGN 1002
CACNA1A 1339 DINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFN 1380
CACNA1B 1244 DINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLN 1285
CACNA1E 1250 DIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFN 1291
CACNA1G 1373 ILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGN 1414
CACNA1H 1391 ILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGN 1432
CACNA1I 1267 ILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGN 1308
SCN5A 1295 EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMN 1336
SCN1A 1308 ELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMN 1349
SCN2A 1298 ELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMN 1339
SCN3A 1296 ELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMN 1337
SCN4A 1121 ELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMN 1162
SCN7A 1022 E---LKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLN 1060
SCN8A 1288 ELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMN 1329
SCN9A 1271 DLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMN 1312
SCN10A 1242 EVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMN 1283
SCN11A 1140 -LMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILN 1180
cons 1975 :: : :: ****:.:.: :: *. :. : * 2016
CACNA1C 1032 IVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY 1073
CACNA1S 931 IVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYY 972
CACNA1D 1038 IMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLF 1079
CACNA1F 1003 IMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSF 1044
CACNA1A 1381 ILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKY 1422
CACNA1B 1286 ILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQY 1327
CACNA1E 1292 ILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNY 1333
CACNA1G 1415 IVVICCAFFIIFGILGVQLFKGKFFVCQGED---------TR 1447
CACNA1H 1433 IVLICCAFFIIFGILGVQLFKGKFYYCEGPD---------TR 1465
CACNA1I 1309 IVLICCAFFIIFGILGVQLFKGKFYHCLGVD---------TR 1341
SCN5A 1337 VLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDL-P-LNYT 1376
SCN1A 1350 VLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDR---FDIE 1388
SCN2A 1340 VLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEM---FDVS 1378
SCN3A 1338 VLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNM---FDIS 1376
SCN4A 1163 VLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSER---FDIS 1201
SCN7A 1061 VFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGER---FPSS 1099
SCN8A 1330 VLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIR---FEIE 1368
SCN9A 1313 VLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSR---FPAS 1351
SCN10A 1284 VLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEF-SLVPLS 1324
SCN11A 1181 VLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVI----NYT 1218
cons 2017 :.:: : ::* :.* :* *: * . 2058
CACNA1C 1074 ITYKDGEVDHP-IIQ--PRSWENSKFDFDNVLAAMMALFTVS 1112
CACNA1S 973 YVYKDGDPMQI-ELR--HREWVHSDFHFDNVLSAMMSLFTVS 1011
CACNA1D 1080 ILYKDGDVDSP-VVR--ERIWQNSDFNFDNVLSAMMALFTVS 1118
CACNA1F 1045 LVYPDGDVSRP-LVR--ERLWVNSDFNFDNVLSAMMALFTVS 1083
CACNA1A 1423 LLYEKNEVK----AR--DREWKKYEFHYDNVLWALLTLFTVS 1458
CACNA1B 1328 LDYEKEEVE----AQ--PRQWKKYDFHYDNVLWALLTLFTVS 1363
CACNA1E 1334 VDHEKNKME----VK--GREWKRHEFHYDNIIWALLTLFTVS 1369
CACNA1G 1448 NITNKSDCA----EA--SYRWVRHKYNFDNLGQALMSLFVLA 1483
CACNA1H 1466 NISTKAQCR----AA--HYRWVRRKYNFDNLGQALMSLFVLS 1501
CACNA1I 1342 NITNRSDCM----AA--NYRWVHHKYNFDNLGQALMSLFVLA 1377
SCN5A 1377 IVNNKSQCESLNLTGE--LYWTKVKVNFDNVGAGYLALLQVA 1416
SCN1A 1389 DVNNHTDCLKLIERNET-ARWKNVKVNFDNVGFGYLSLLQVA 1429
SCN2A 1379 VVNNYSECKALIESNQT-ARWKNVKVNFDNVGLGYLSLLQVA 1419
SCN3A 1377 DVNNLSDCQALGK--Q--ARWKNVKVNFDNVGAGYLALLQVA 1414
SCN4A 1202 EVNNKSECESLMHTGQ--VRWLNVKVNYDNVGLGYLSLLQVA 1241
SCN7A 1100 EVMNKSRCESLLFNES--MLWENAKMNFDNVGNGFLSLLQVA 1139
SCN8A 1369 DVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVA 1410
SCN9A 1352 QVPNRSECFALMNVSQN-VRWKNLKVNFDNVGLGYLSLLQVA 1392
SCN10A 1325 IVNNKSDCKIQNSTGS--FFWVNVKVNFDNVAMGYLALLQVA 1364
SCN11A 1219 IITNKSQCESGN------FSWINQKVNFDNVGNAYLALLQVA 1254
cons 2059 * . . .:**: . ::*: :: 2100
CACNA1C 1113 TFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIA 1154
CACNA1S 1012 TFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIA 1053
CACNA1D 1119 TFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVA 1160
CACNA1F 1084 TFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIA 1125
CACNA1A 1459 TAEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFP 1500
CACNA1B 1364 TGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFP 1405
CACNA1E 1370 TGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFP 1411
CACNA1G 1484 SKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1525
CACNA1H 1502 SKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVS 1543
CACNA1I 1378 SKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1419
SCN5A 1417 TFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1458
SCN1A 1430 TFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGS 1471
SCN2A 1420 TFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGS 1461
SCN3A 1415 TFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGS 1456
SCN4A 1242 TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGS 1283
SCN7A 1140 TFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGV 1181
SCN8A 1411 TFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGS 1452
SCN9A 1393 TFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGS 1434
SCN10A 1365 TFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGG 1406
SCN11A 1255 TFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGS 1296
cons 2101 : .** :: .:* . * ::: :::. 2142
CACNA1C 1155 FFMMNIFVGFVIVTFQEQGEQE----YKNCELDKNQR----- 1187
CACNA1S 1054 FFMMNIFVGFVIVTFQEQGETE----YKNCELDKNQR----- 1086
CACNA1D 1161 FFMMNIFVGFVIVTFQEQGEKE----YKNCELDKNQR----- 1193
CACNA1F 1126 FFMMNIFVGFVIITFRAQGEQE----YQNCELDKNQR----- 1158
CACNA1A 1501 FFFVNIFVALIIITFQEQGDKM----MEEYSLEKNER----- 1533
CACNA1B 1406 FFFVNIFVALIIITFQEQGDKV----MSECSLEKNER----- 1438
CACNA1E 1412 FFFVNIFVALIIITFQEQGDKM----MEECSLEKNER----- 1444
CACNA1G 1526 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKR 1567
CACNA1H 1544 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEK--------- 1576
CACNA1I 1420 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEK--------- 1452
SCN5A 1459 FFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYY----- 1495
SCN1A 1472 FFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYY----- 1508
SCN2A 1462 FFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYY----- 1498
SCN3A 1457 FFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYY----- 1493
SCN4A 1284 FFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYY----- 1320
SCN7A 1182 FLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQY----- 1218
SCN8A 1453 FFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYY----- 1489
SCN9A 1435 FFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYY----- 1471
SCN10A 1407 FFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYY----- 1443
SCN11A 1297 FFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYY----- 1333
cons 2143 *: :.::: .:: .*. . 2184
CACNA1C 1188 -QCV---EY-AL------KARP-------LRRYIPK--NQHQ 1209
CACNA1S 1087 -QCV---QY-AL------KARP-------LRCYIPK--NPYQ 1108
CACNA1D 1194 -QCV---EY-AL------KARP-------LRRYIPK--NPYQ 1215
CACNA1F 1159 -QCV---EY-AL------KAQP-------LRRYIPK--NPHQ 1180
CACNA1A 1534 -ACI---DF-AI------SAKP-------LTRHMPQNKQSFQ 1557
CACNA1B 1439 -ACI---DF-AI------SAKP-------LTRYMPQNRQSFQ 1462
CACNA1E 1445 -ACI---DF-AI------SAKP-------LTRYMPQNRHTFQ 1468
CACNA1G 1568 RNLML--DD-VI-----ASGSSASAASEAQCKPYYSDYSRFR 1601
CACNA1H 1577 -RLRRLERR-RRSTFPSPEAQ---------RRPYYADYSPTR 1607
CACNA1I 1453 -RLRRLEKK-RR------KAQ---------RLPYYATYCHTR 1477
SCN5A 1496 -NAM---KKLG-------SKKP--------QKPIPRPLNKYQ 1518
SCN1A 1509 -NAM---KKLG-------SKKP--------QKPIPRPGNKFQ 1531
SCN2A 1499 -NAM---KKLG-------SKKP--------QKPIPRPANKFQ 1521
SCN3A 1494 -NAM---KKLG-------SKKP--------QKPIPRPANKFQ 1516
SCN4A 1321 -NAM---KKLG-------SKKP--------QKPIPRPQNKIQ 1343
SCN7A 1219 -RRL---KKLM-------YEDS--------QRPVPRPLNKLQ 1241
SCN8A 1490 -NAM---KKLG-------SKKP--------QKPIPRPLNKIQ 1512
SCN9A 1472 -NAM---KKLG-------SKKP--------QKPIPRPGNKIQ 1494
SCN10A 1444 -NAM---KKLG-------SKKP--------QKPIPRPLNKFQ 1466
SCN11A 1334 -NAM---KKLG-------SKKP--------QKPIPRPLNKCQ 1356
cons 2185 : 2226
CACNA1C 1210 YKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAM 1251
CACNA1S 1109 YQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHIS 1150
CACNA1D 1216 YKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAM 1257
CACNA1F 1181 YRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAM 1222
CACNA1A 1558 YRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENAL 1599
CACNA1B 1463 YKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELML 1504
CACNA1E 1469 YRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELAL 1510
CACNA1G 1602 LLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL 1643
CACNA1H 1608 RSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEAL 1649
CACNA1I 1478 LLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETAL 1519
SCN5A 1519 GFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560
SCN1A 1532 GMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTIL 1573
SCN2A 1522 GMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNIL 1563
SCN3A 1517 GMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVL 1558
SCN4A 1344 GMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDIL 1385
SCN7A 1242 GFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIAL 1283
SCN8A 1513 GIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENIL 1554
SCN9A 1495 GCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVL 1536
SCN10A 1467 GFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKIL 1508
SCN11A 1357 GLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSIL 1398
cons 2227 :: : :* .: : : . 2268
CACNA1C 1252 NILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVG 1293
CACNA1S 1151 DILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIG 1192
CACNA1D 1258 DILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIG 1299
CACNA1F 1223 DILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVG 1264
CACNA1A 1600 RVFNIAFTSLFSLECVLKAMAFGILNYFRDAWNIFDFVTVLG 1641
CACNA1B 1505 KCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLG 1546
CACNA1E 1511 KYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIG 1552
CACNA1G 1644 KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLL 1685
CACNA1H 1650 KYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLL 1691
CACNA1I 1520 KYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLL 1561
SCN5A 1561 AKINLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVIL 1601
SCN1A 1574 SRINLVFIVLFTGECVLKLISLR-HYYFTIGWNIFDFVVVIL 1614
SCN2A 1564 YWINLVFIVLFTGECVLKLISLR-YYYFTIGWNIFDFVVVIL 1604
SCN3A 1559 SRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVIL 1599
SCN4A 1386 YNINMIFIIIFTGECVLKMLALR-QYYFTVGWNIFDFVVVIL 1426
SCN7A 1284 YWINSIFVMLYTMECILKLIAFR-CFYFTIAWNIFDFMVVIF 1324
SCN8A 1555 YWINLVFVIFFTCECVLKMFALR-HYYFTIGWNIFDFVVVIL 1595
SCN9A 1537 YWINVVFIILFTGECVLKLISLR-HYYFTVGWNIFDFVVVII 1577
SCN10A 1509 GKINQFFVAVFTGECVMKMFALR-QYYFTNGWNVFDFIVVVL 1549
SCN11A 1399 DHLNWVFVVIFTLECLIKIFALR-QYYFTNGWNLFDCVVVLL 1439
cons 2269 * * .: * .* :: :* ** :* *: 2310
CACNA1C 1294 SIVDIAITEVNPAE----HTQ----CSPSMNAEENSRISITF 1327
CACNA1S 1193 SIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAF 1234
CACNA1D 1300 SIIDVALSEADPTE----SENVPVPTATPGNSEESNRISITF 1337
CACNA1F 1265 SIVDIAVTEVNNGG----HLG----E----SSEDSSRISITF 1294
CACNA1A 1642 SITDILVTEFGNN-----------------------FINLSF 1660
CACNA1B 1547 SITDILVTEIAET---------------------NNFINLSF 1567
CACNA1E 1553 SITEIILTDSKLV--------------------NTSGFNMSF 1574
CACNA1G 1686 SIMGITLEEIEVN--------------------ASLPINPTI 1707
CACNA1H 1692 SLMGITLEEIEMS--------------------AALPINPTI 1713
CACNA1I 1562 SVMGITLEEIEIN--------------------AALPINPTI 1583
SCN5A 1602 SIVGTVLSDIIQ----------------------KYFFSPTL 1621
SCN1A 1615 SIVGMFLAELIE----------------------KYFVSPTL 1634
SCN2A 1605 SIVGMFLAELIE----------------------KYFVSPTL 1624
SCN3A 1600 SIVGMFLAEMIE----------------------KYFVSPTL 1619
SCN4A 1427 SIVGLALSDLIQ----------------------KYFVSPTL 1446
SCN7A 1325 SITGLCLPMTVG----------------------SYLVPPSL 1344
SCN8A 1596 SIVGMFLADIIE----------------------KYFVSPTL 1615
SCN9A 1578 SIVGMFLADLIE----------------------TYFVSPTL 1597
SCN10A 1550 SIASLIFSAILKS--------------------LQSYFSPTL 1571
SCN11A 1440 SIVSTMISTLENQ--------------------EHIPFPPTL 1461
cons 2311 *: . . :: 2352
CACNA1C 1328 FRLFRV---MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALL 1366
CACNA1S 1235 FRLFRV---MRLIKLLSRAEGVRTLLWTFIKSFQALPYVALL 1273
CACNA1D 1338 FRLFRV---MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALL 1376
CACNA1F 1295 FRLFRV---MRLVKLLSKGEGIRTLLWTFIKSFQALPYVALL 1333
CACNA1A 1661 LRLFRA---ARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1699
CACNA1B 1568 LRLFRA---ARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1606
CACNA1E 1575 LKLFRA---ARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1613
CACNA1G 1708 IRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLL 1749
CACNA1H 1714 IRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLL 1755
CACNA1I 1584 IRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLL 1625
SCN5A 1622 FRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLL 1663
SCN1A 1635 FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1676
SCN2A 1625 FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1666
SCN3A 1620 FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1661
SCN4A 1447 FRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLL 1488
SCN7A 1345 VQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILL 1386
SCN8A 1616 FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1657
SCN9A 1598 FRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLL 1639
SCN10A 1572 FRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLL 1613
SCN11A 1462 FRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLL 1503
cons 2353 .::. ::::* .: *: ..: :: : : ** 2394
CACNA1C 1367 IVMLFFIYAVIGMQVFGKIALND---TTE-----INRNNNFQ 1400
CACNA1S 1274 IVMLFFIYAVIGMQMFGKIALVD---GTQ-----INRNNNFQ 1307
CACNA1D 1377 IAMLFFIYAVIGMQMFGKVAMRD---NNQ-----INRNNNFQ 1410
CACNA1F 1334 IAMIFFIYAVIGMQMFGKVALQD---GTQ-----INRNNNFQ 1367
CACNA1A 1700 IAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFR 1741
CACNA1B 1607 IAMLFFIYAIIGMQVFGNIALDD---DTS-----INRHNNFR 1640
CACNA1E 1614 IAMLFFIYAIIGMQVFGNIKLDE---ESH-----INRHNNFR 1647
CACNA1G 1750 FMLLFFIFAALGVELFGDLECDET---HP--CEGLGRHATFR 1786
CACNA1H 1756 FMLLFFIYAALGVELFGRLECSED---NP--CEGLSRHATFS 1792
CACNA1I 1626 FMLLFFIYAALGVELFGKLVCNDE---NP--CEGMSRHATFE 1662
SCN5A 1664 LFLVMFIYSIFGMANFAYVKW-----EAG-----IDDMFNFQ 1695
SCN1A 1677 LFLVMFIYAIFGMSNFAYVKR-----EVG-----IDDMFNFE 1708
SCN2A 1667 LFLVMFIYAIFGMSNFAYVKR-----EVG-----IDDMFNFE 1698
SCN3A 1662 LFLVMFIYAIFGMSNFAYVKK-----EAG-----IDDMFNFE 1693
SCN4A 1489 LFLVMFIYSIFGMSNFAYVKK-----ESG-----IDDMFNFE 1520
SCN7A 1387 IFLVMFIYAVFGMYNFAYVKK-----EAG-----INDVSNFE 1418
SCN8A 1658 LFLVMFIFSIFGMSNFAYVKH-----EAG-----IDDMFNFE 1689
SCN9A 1640 LFLVMFIYAIFGMSNFAYVKK-----EDG-----INDMFNFE 1671
SCN10A 1614 LFLVMFIYSIFGMSSFPHVRW-----EAG-----IDDMFNFQ 1645
SCN11A 1504 LFLIMFIYAILGMNWFSKVNP-----ESG-----IDDIFNFK 1535
cons 2395 : :::**:: :*: * : : .* 2436
CACNA1C 1401 TFPQAVLLLFRCATGEAWQDIMLACMPG--KKCAPESEP-SN 1439
CACNA1S 1308 TFPQAVLLLFRCATGEAWQEILLACSYG--KLCDPESDY--A 1345
CACNA1D 1411 TFPQAVLLLFRCATGEAWQEIMLACLPG--KLCDPESDY--N 1448
CACNA1F 1368 TFPQAVLLLFRCATGEAWQEIMLASLPG--NRCDPESDF--G 1405
CACNA1A 1742 TFFQALMLLFRSATGEAWHNIMLSCLSG--KPCDKNSGIL-- 1779
CACNA1B 1641 TFLQALMLLFRSATGEAWHEIMLSCLSN--QACDE---Q--- 1674
CACNA1E 1648 SFFGSLMLLFRSATGEAWQEIMLSCLGE--KGCEPDTTAPSG 1687
CACNA1G 1787 NFGMAFLTLFRVSTGDNWNGIMKDTLRD----CDQEST---- 1820
CACNA1H 1793 NFGMAFLTLFRVSTGDNWNGIMKDTLRE----CSREDKH--- 1827
CACNA1I 1663 NFGMAFLTLFQVSTGDNWNGIMKDTLRD----CTHDERS--- 1697
SCN5A 1696 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPN-S- 1735
SCN1A 1709 TFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVN-PG 1749
SCN2A 1699 TFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDH-PG 1739
SCN3A 1694 TFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIH-PG 1734
SCN4A 1521 TFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLEN-PG 1561
SCN7A 1419 TFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKIN-PG 1459
SCN8A 1690 TFGNSMICLFQITTSAGWDGLLLPILN-RPPDCSLDKEH-PG 1729
SCN9A 1672 TFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVH-PG 1712
SCN10A 1646 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPN-S- 1685
SCN11A 1536 TFASSMLCLFQISTSAGWDSLLSPMLRSKES-CN-------- 1568
cons 2437 .* :.: **. : *. :: * 2478
CACNA1C 1440 STEGETP--CGS-SFAVFYFISFYMLCAFLIINLFVAVIMDN 1478
CACNA1S 1346 PGE-EYT--CGT-NFAYYYFISFYMLCAFLVINLFVAVIMDN 1383
CACNA1D 1449 PGE-EYT--CGS-NFAIVYFISFYMLCAFLIINLFVAVIMDN 1486
CACNA1F 1406 PGE-EFT--CGS-NFAIAYFISFFMLCAFLIINLFVAVIMDN 1443
CACNA1A 1780 ---T-R--ECGN-EFAYFYFVSFIFLCSFLMLNLFVAVIMDN 1814
CACNA1B 1675 ---A-NATECGS-DFAYFYFVSFIFLCSFLMLNLFVAVIMDN 1711
CACNA1E 1688 QNEN-E--RCGT-DLAYVYFVSFIFFCSFLMLNLFVAVIMDN 1725
CACNA1G 1821 -C-------YNT-VISPIYFVSFVLTAQFVLVNVVIAVLMKH 1853
CACNA1H 1828 -C---LS--YLP-ALSPVYFVTFVLVAQFVLVNVVVAVLMKH 1862
CACNA1I 1698 -C---LS--SLQ-FVSPLYFVSFVLTAQFVLINVVVAVLMKH 1732
SCN5A 1736 NGSRGD---CGSPAVGILFFTTYIIISFLIVVNMYIAIILEN 1774
SCN1A 1750 SSVKGD---CGNPSVGIFFFVSYIIISFLVVVNMYIAVILEN 1788
SCN2A 1740 SSVKGD---CGNPSVGIFFFVSYIIISFLVVVNMYIAVILEN 1778
SCN3A 1735 SSVKGD---CGNPSVGIFFFVSYIIISFLVVVNMYIAVILEN 1773
SCN4A 1562 TSVKGD---CGNPSIGICFFCSYIIISFLIVVNMYIAIILEN 1600
SCN7A 1460 TQVRGD---CGNPSVGIFYFVSYILISWLIIVNMYIVVVMEF 1498
SCN8A 1730 SGFKGD---CGNPSVGIFFFVSYIIISFLIVVNMYIAIILEN 1768
SCN9A 1713 SSVEGD---CGNPSVGIFYFVSYIIISFLVVVNMYIAVILEN 1751
SCN10A 1686 NGTRGD---CGSPAVGIIFFTTYIIISFLIMVNMYIAVILEN 1724
SCN11A 1569 -SSSEN---CHLPGIATSYFVSYIIISFLIVVNMYIAVILEN 1606
cons 2479 .. :* :: : . ::::*: :.:::. 2520
CACNA1C 1479 FDYLTRDWSI-LGPHHLDEFKRIWAEYDPEAKGRIKHLDVVT 1519
CACNA1S 1384 FDYLTRDWSI-LGPHHLDEFKAIWAEYDPEAKGRIKHLDVVT 1424
CACNA1D 1487 FDYLTRDWSI-LGPHHLDEFKRIWSEYDPEAKGRIKHLDVVT 1527
CACNA1F 1444 FDYLTRDWSI-LGPHHLDEFKRIWSEYDPGAKGRIKHLDVVA 1484
CACNA1A 1815 FEYLTRDSSI-LGPHHLDEYVRVWAEYDPAACGRIHYKDMYS 1855
CACNA1B 1712 FEYLTRDSSI-LGPHHLDEFIRVWAEYDPAACGRISYNDMFE 1752
CACNA1E 1726 FEYLTRDSSI-LGPHHLDEFVRVWAEYDRAACGRIHYTEMYE 1766
CACNA1G 1854 LEESNKEAKE---EAELEAELELEMKT-LSPQPHSPLGSPF- 1890
CACNA1H 1863 LEESNKEARE---DAELDAEIELEMAQGPGSARRVDADRP-- 1899
CACNA1I 1733 LDDSNKEAQE---DAEMDAELELEMAHGLGPGPRLPTGSPGA 1771
SCN5A 1775 FSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSD 1816
SCN1A 1789 FSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQ 1830
SCN2A 1779 FSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSD 1820
SCN3A 1774 FSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSD 1815
SCN4A 1601 FNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSD 1642
SCN7A 1499 LNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSD 1540
SCN8A 1769 FSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLAD 1810
SCN9A 1752 FSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSD 1793
SCN10A 1725 FNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSD 1766
SCN11A 1607 FNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSD 1648
cons 2521 :. ... .: 2562
CACNA1C 1520 LLRRIQPPLG--FGKLCPHRVACKRLVSMNMPLNSDG-TVMF 1558
CACNA1S 1425 LLRRIQPPLG--FGKFCPHRVACKRLVGMNMPLNSDG-TVTF 1463
CACNA1D 1528 LLRRIQPPLG--FGKLCPHRVACKRLVAMNMPLNSDG-TVMF 1566
CACNA1F 1485 LLRRIQPPLG--FGKLCPHRVACKRLVAMNMPLNSDG-TVTF 1523
CACNA1A 1856 LLRVISPPLG--LGKKCPHRVACKRLLRMDLPVADD-NTVHF 1894
CACNA1B 1753 MLKHMSPPLG--LGKKCPARVAYKRLVRMNMPISNEDMTVHF 1792
CACNA1E 1767 MLTLMSPPLG--LGKRCPSKVAYKRLVLMNMPVAED-MTVHF 1805
CACNA1G 1891 LWPGVEGPDS--PDSPKPGAL---------HPAAHA-RSASH 1920
CACNA1H 1900 -------PLP--QESPG--AR--------DAPN--------- 1913
CACNA1I 1772 PGR---GPGGAGGGGDT--EG---GLCRRCYSPAQE-N--LW 1802
SCN5A 1817 FADALSEPLR--IAK--PNQI---SLINMDLPMVSGD-RIHC 1850
SCN1A 1831 FAAALEPPLN--LPQ--PNKL---QLIAMDLPMVSGD-RIHC 1864
SCN2A 1821 FADALDPPLL--IAK--PNKV---QLIAMDLPMVSGD-RIHC 1854
SCN3A 1816 FAAALDPPLL--IAK--PNKV---QLIAMDLPMVSGD-RIHC 1849
SCN4A 1643 FVDTLQEPLR--IAK--PNKI---KLITLDLPMVPGD-KIHC 1676
SCN7A 1541 FAAALDPPLF--MAK--PNKG---QLIALDLPMAVGD-RIHC 1574
SCN8A 1811 FADALEHPLR--VPK--PNTI---ELIAMDLPMVSGD-RIHC 1844
SCN9A 1794 FAAALDPPLL--IAK--PNKV---QLIAMDLPMVSGD-RIHC 1827
SCN10A 1767 FADTLSGPLR--IPK--PNRN---ILIQMDLPLVPGD-KIHC 1800
SCN11A 1649 FADALPEPLR--VAK--PNKY---QFLVMDLPMVSED-RLHC 1682
cons 2563 * . 2604
CACNA1C 1559 NATLFALVRTALRIKTEG---NLEQANEELRAIIKKIW-KRT 1596
CACNA1S 1464 NATLFALVRTALKIKTEG---NFEQANEELRAIIKKIW-KRT 1501
CACNA1D 1567 NATLFALVRTALKIKTEG---NLEQANEELRAVIKKIW-KKT 1604
CACNA1F 1524 NATLFALVRTSLKIKTEG---NLEQANQELRIVIKKIW-KRM 1561
CACNA1A 1895 NSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIW-PNL 1935
CACNA1B 1793 TSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISVVW-ANL 1833
CACNA1E 1806 TSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIW-PHL 1846
CACNA1G 1921 FSLEHPTDRQLFDTI---S--LLIQGSLEWELKLMDEL-AGP 1956
CACNA1H 1914 ------LVARKV----------------SVSRML-SLPNDSY 1932
CACNA1I 1803 LDSVSLIIKDSL----------------EGELTIIDNL-SGS 1827
SCN5A 1851 MDILFAFTKRVLGES--G---EMDALKIQMEEKFMA---ANP 1884
SCN1A 1865 LDILFAFTKRVLGES--G---EMDALRIQMEERFMA---SNP 1898
SCN2A 1855 LDILFAFTKRVLGES--G---EMDALRIQMEERFMA---SNP 1888
SCN3A 1850 LDILFAFTKRVLGES--G---EMDALRIQMEDRFMA---SNP 1883
SCN4A 1677 LDILFALTKEVLGDS--G---EMDALKQTMEEKFMA---ANP 1710
SCN7A 1575 LDILLAFTKRVMGQD--V---RMEKVVSEIESGFLL---ANP 1608
SCN8A 1845 LDILFAFTKRVLGDS--G---ELDILRQQMEERFVA---SNP 1878
SCN9A 1828 LDILFAFTKRVLGES--G---EMDSLRSQMEERFMS---ANP 1861
SCN10A 1801 LDILFAFTKNVLGES--G---ELDSLKANMEEKFMA---TNL 1834
SCN11A 1683 MDILFAFTARVLGGS--D---GLDSMKAMMEEKFME---ANP 1716
cons 2605 . 2646
CACNA1C 1597 -SMKLLDQVVPPAGDDEVTVGKFYATFLIQEYF-RKFKKRKE 1636
CACNA1S 1502 -SMKLLDQVIPPIGDDEVTVGKFYATFLIQEHF-RKFMKRQE 1541
CACNA1D 1605 -SMKLLDQVVPPAGDDEVTVGKFYATFLIQDYF-RKFKKRKE 1644
CACNA1F 1562 -KQKLLDEVIPPPDEEEVTVGKFYATFLIQDYF-RKFRRRKE 1601
CACNA1A 1936 -SQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYY-RQSKAKK- 1974
CACNA1B 1834 -PQKTLDLLVPPHKPDEMTVGKVYAALMIFDFY-KQNKTTRD 1873
CACNA1E 1847 -SQKMLDLLVPMPKASDLTVGKIYAAMMIMDYY-KQSKVKKQ 1886
CACNA1G 1957 GGQPSAFPSAPSLGGSDP-----QIPLAEMEAL-SLTSEIVS 1992
CACNA1H 1933 M----FRPVVPASAPHPR-----PLQEVEMETYGAGTPLGSV 1965
CACNA1I 1828 I----FHHYSSPAGCKKCHHDKQEVQLAETEAF-SLNSDRSS 1864
SCN5A 1885 -SKISYEPITTTLRRKHEEVS----AMVIQRAF-RRHLLQRS 1920
SCN1A 1899 -SKVSYQPITTTLKRKQEEVS----AVIIQRAY-RRHLLKRT 1934
SCN2A 1889 -SKVSYEPITTTLKRKQEEVS----AIIIQRAY-RRYLLKQK 1924
SCN3A 1884 -SKVSYEPITTTLKRKQEEVS----AAIIQRNF-RCYLLKQR 1919
SCN4A 1711 -SKVSYEPITTTLKRKHEEVC----AIKIQRAY-RRHLLQRS 1746
SCN7A 1609 -FKITCEPITTTLKRKQEAVS----ATIIQRAY-KNYRLRRN 1644
SCN8A 1879 -SKVSYEPITTTLRRKQEEVS----AVVLQRAY-RGHLARRG 1914
SCN9A 1862 -SKVSYEPITTTLKRKQEDVS----ATVIQRAY-RRYRLRQN 1897
SCN10A 1835 -SKSSYEPIATTLRWKQEDIS----ATVIQKAY-RSYVLHRS 1870
SCN11A 1717 -LKKLYEPIVTTTKRKEEERG----AAIIQKAF-RKYMMKVT 1752
cons 2647 . 2688
CACNA1C 1637 --QGLVGK--PS--------QRNALS-L-QAGLRTL-H-DIG 1662
CACNA1S 1542 --EYY-GY--RP--------KKDIVQ-I-QAGLRTI-EEEAA 1567
CACNA1D 1645 --QGLVGK-YPA--------KNTTIA-L-QAGLRTL-H-DIG 1671
CACNA1F 1602 --KGLLGN-DAA--------PSTSSA-L-QAGLRSL-Q-DLG 1628
CACNA1A 1975 -LQAMRE---EQDRTPLMFQRMEPPS------PTQ------- 1999
CACNA1B 1874 QMQQAPGG--LSQM----GPVSLFHP------LKATLE-QT- 1901
CACNA1E 1887 --RQQLE---E-QKNAPMFQRMEPSS------LPQ------- 1909
CACNA1G 1993 --EPSC-----------------SLA------LTD------- 2002
CACNA1H 1966 --ASVHSP-PAE-SCASLQIPLAVSS------PAR------- 1990
CACNA1I 1865 --SILLGD-DLS-LEDPTACPPGRKD------SKG------- 1889
SCN5A 1921 --LKHASFLFRQ---------QAGSGLSEEDAPEREGL-IAY 1950
SCN1A 1935 --VKQASFTYNK---------NKIKG--GANLLIKEDM-IID 1962
SCN2A 1925 --VKKVSSIYKK---------DKGKE--CDGTPIKEDT-LID 1952
SCN3A 1920 --LKNISSNYNK---------EAIKG--RIDLPIKQDM-IID 1947
SCN4A 1747 --MKQASYMYRH---------SHDGS--GDDAPEKEGL-LAN 1774
SCN7A 1645 --DKNTSDIHMI---------DGDR----DVHATKEGA-YFD 1670
SCN8A 1915 --FIC-----------------------------KKTT-SNK 1924
SCN9A 1898 --VKNISSIYIK---------DGDRD---DDLLNKKDM-AFD 1924
SCN10A 1871 --MALSNTPCVP---------RAEEE---AASLPDEGF-VAF 1897
SCN11A 1753 --KGDQG-DQN-------------------------D----L 1762
cons 2689 2730
CACNA1C 1663 PE-IRRA--------I-------------------------- 1669
CACNA1S 1568 PE-ICRT--------V-------------------------- 1574
CACNA1D 1672 PE-IRRA--------I-------------------------- 1678
CACNA1F 1629 PE-MRQA--------L-------------------------- 1635
CACNA1A 2000 EG-GP-G--------QNALPSTQLDPGGALMA---HESGLKE 2028
CACNA1B 1902 QPAVLRGARVFLR--QKS--STSLSNGGAIQN---QESGIKE 1936
CACNA1E 1910 EI-IA-N--------AKALPYLQQDPVSGL-------SGRSG 1934
CACNA1G 2003 DSLP---------DDMHTLLLSALESNMQPH---PTELPGPD 2032
CACNA1H 1991 SGEPLHALSP-RGTARSPSLSRLLCRQEAVH---TDSLEGKI 2028
CACNA1I 1890 ELDP-----P-EPMRVGDLGECFFPLSSTAVSPDPENFLCEM 1925
SCN5A 1951 VM-SE------------------------------------- 1954
SCN1A 1963 RI-NE------------------------------------- 1966
SCN2A 1953 KL-NE------------------------------------- 1956
SCN3A 1948 KL-NG------------------------------------- 1951
SCN4A 1775 TM-SKMY---------------------GH------------ 1782
SCN7A 1671 KA-KE------------------------------------- 1674
SCN8A 1925 LE-NG------------------------------------- 1928
SCN9A 1925 NV-NE------------------------------------- 1928
SCN10A 1898 TA-NE------------------------------------- 1901
SCN11A 1763 -E-NG------------------------------------- 1765
cons 2731 2772
CACNA1C 1670 ---------------SGD-LTAEEELDKAMKEAVSAASED-D 1694
CACNA1S 1575 ---------------SGD-LAAEEELE---RAMVEAAMEE-G 1596
CACNA1D 1679 ---------------SCD-LQDDEPEE---TKR---EEED-D 1697
CACNA1F 1636 ---------------TCD-TEEEEEEG---QEGVEEEDEK-D 1657
CACNA1A 2029 SPSWVTQRAQEMFQKTGTWSPEQGPPTD---MP---NSQP-N 2063
CACNA1B 1937 SVSWGTQRTQDAPHEA-RPPLERGHSTE---IP---VGRS-G 1970
CACNA1E 1935 YPSMSPLSPQDIFQLACMDPADDGQFQE---RQ---SLEP-E 1969
CACNA1G 2033 LLTVRKSGVSRTHSLPNDSYMCRHGSTA---EG---PLGH-R 2067
CACNA1H 2029 DSPRDTLDPAEPGEKTPVRPVTQGGSLQ---SP---PRSP-R 2063
CACNA1I 1926 EEIPFNPVRSWLKHDSSQAPPSPFSPDA---SS---PLLP-M 1960
SCN5A 1955 ------------------------------------NF-SRP 1959
SCN1A 1967 ------------------------------------NS-I-- 1969
SCN2A 1957 ------------------------------------NS-T-- 1959
SCN3A 1952 ------------------------------------NS-T-- 1954
SCN4A 1783 ---------------E----N--------------GNSSS-- 1789
SCN7A 1675 ------------------------------------KS---- 1676
SCN8A 1929 ------------------------------------GT-H-- 1931
SCN9A 1929 ------------------------------------NS-S-- 1931
SCN10A 1902 ------------------------------------NC-V-- 1904
SCN11A 1766 ------------------------------------PH---- 1767
cons 2773 2814
CACNA1C 1695 IFRRAGGL----FGNHV-SYYQSD-------------G---- 1714
CACNA1S 1597 IFRRTGGL----FGQVD-NFL--E-------------R---- 1614
CACNA1D 1698 VFKRNGAL----LGNHV-NHVNSD-------------R---- 1717
CACNA1F 1658 LETNKATM----VSQPS-AR---R-------------G---- 1674
CACNA1A 2064 SQSVEMRE----MGRDG-YSDSEH-------------YLPME 2087
CACNA1B 1971 ALAVDVQM----QSITRRGPDGEP-------------QPGLE 1995
CACNA1E 1970 VSELKSVQ----PSNHG-IYLPSD-------------TQEHA 1993
CACNA1G 2068 GWGLPKA------------------QSGSVLSVHSQP----- 2086
CACNA1H 2064 PASVRT------------------RKHTFGQRCVSSRPAAP- 2086
CACNA1I 1961 PAEFFHPA----VSASQ-KGPEKGTGTGTLPKIALQGSWASL 1997
SCN5A 1960 LG-PPSSSSISSTSF-P-PSYDSV-------------TRATS 1985
SCN1A 1970 ---TEKTDLTMSTAACP-PSYDRV-------------TKPIV 1994
SCN2A 1960 ---PEKTDMTPSTTS-P-PSYDSV-------------TKPEK 1983
SCN3A 1955 ---PEKTDGSSSTTS-P-PSYDSV-------------TKPDK 1978
SCN4A 1790 ---PSPEEKGEAGDA-G-PTMGLM-------------PISPS 1813
SCN7A 1677 ------------------------------------------ 1676
SCN8A 1932 ---REKKESTPSTAS-L-PSYDSV-------------TKPEK 1955
SCN9A 1932 ---PEKTDATSSTTS-P-PSYDSV-------------TKPDK 1955
SCN10A 1905 -L-PDKSETASATSF-P-PSYESV-------------TRGLS 1929
SCN11A 1768 -S-PLQTL-----------CNGDL-------------SSFGV 1783
cons 2815 2856
CACNA1C 1715 --------------RSAFPQTFT---TQRPLHINKAGSS-QG 1738
CACNA1S 1615 --------------TNSLPPVMA---NQRPLQFAEIE---ME 1636
CACNA1D 1718 --------------RDSLQQTNT---THRPLHVQRPSIPPAS 1742
CACNA1F 1675 --------------SGISVSLPVGDRLPDSLSFG---P---- 1695
CACNA1A 2088 ------GQGR----AASMPRLPA---EN-------------- 2102
CACNA1B 1996 ------SQGR----AASMPRLAA---ET-------------- 2010
CACNA1E 1994 ------GSGR----ASSMPRLTV---DP-------------- 2008
CACNA1G 2087 ---------ADTSYILQLPKDAP---HLLQPH---------- 2106
CACNA1H 2087 ---------GGEEAEASDPADEE---VSHITS---------- 2106
CACNA1I 1998 ------RSPRVNCTLLRQATGSD---TSLDAS---------- 2020
SCN5A 1986 DN-LQVRGSD----YSHSED---------------------- 2000
SCN1A 1995 EK-HE---QE----GKDEKA---------------------- 2006
SCN2A 1984 EK-FE---KD----KSEKED---------------------- 1995
SCN3A 1979 EK-FE---KD----KPEKES---------------------- 1990
SCN4A 1814 DTAWP---PA----PPPGQT---------------------- 1826
SCN7A 1677 --------------P--------------------------- 1677
SCN8A 1956 EK-QQRAEEG----RRERAK---------------------- 1970
SCN9A 1956 EK-YE---QD----RTEKED---------------------- 1967
SCN10A 1930 DR-VNMRTSS----SIQNED---------------------- 1944
SCN11A 1784 AK-------G----KVHC------------------------ 1790
cons 2857 2898
CACNA1C 1739 DTESPSHEKLVDSTFTPSSYS-------STGSNANINNANNT 1773
CACNA1S 1637 EMESPVFL---ED-FPQDPRT-------NPLARANTNNAN-- 1665
CACNA1D 1743 DTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMS 1784
CACNA1F 1696 ------SDDDRG---------T------PTSSQPSVPQAGSN 1716
CACNA1A 2103 -----------------------------QRRRG-------- 2107
CACNA1B 2011 -----------------------------Q------------ 2011
CACNA1E 2009 -----------------------------Q------------ 2009
CACNA1G 2107 -----SAPTWGTIPK-------------LP----PP---GRS 2123
CACNA1H 2107 -----SACPWQPTAE-------------PH------------ 2118
CACNA1I 2021 -----PSSSAGSL-Q-------------TT----LE---DSL 2036
SCN5A 2001 ------------------------------------------ 2000
SCN1A 2007 ------------------------------------------ 2006
SCN2A 1996 ------------------------------------------ 1995
SCN3A 1991 ------------------------------------------ 1990
SCN4A 1827 ------------------------------------------ 1826
SCN7A 1678 ------------------------------------------ 1677
SCN8A 1971 ------------------------------------------ 1970
SCN9A 1968 ------------------------------------------ 1967
SCN10A 1945 ------------------------------------------ 1944
SCN11A 1791 ------------------------------------------ 1790
cons 2899 2940
CACNA1C 1774 ALGRLPRPAG----YPSTVSTVEGHGPPLSPAIR--V---QE 1806
CACNA1S 1666 ------------------------------------------ 1665
CACNA1D 1785 KAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSV---KR 1823
CACNA1F 1717 THRRGSG----------------------------------- 1723
CACNA1A 2108 ------RPR----------GNNLSTISDTSPMKRSAS---VL 2130
CACNA1B 2012 -------P-----------------VTDASPMKRSIS---TL 2026
CACNA1E 2010 ------------------------VVTDPSSMRRSFS---TI 2024
CACNA1G 2124 PL----------------------------------AQRPLR 2131
CACNA1H 2119 ------------------------------------------ 2118
CACNA1I 2037 TL----------------------------------SDS--- 2041
SCN5A 2001 ------------------------------------------ 2000
SCN1A 2007 ------------------------------------------ 2006
SCN2A 1996 ------------------------------------------ 1995
SCN3A 1991 ------------------------------------------ 1990
SCN4A 1827 ------------------------------------------ 1826
SCN7A 1678 ------------------------------------------ 1677
SCN8A 1971 ------------------------------------------ 1970
SCN9A 1968 ------------------------------------------ 1967
SCN10A 1945 ------------------------------------------ 1944
SCN11A 1791 ------------------------------------------ 1790
cons 2941 2982
CACNA1C 1807 VAWKLSSNRCHSR-ESQAAMAGQEET------------SQDE 1835
CACNA1S 1666 ------------------------------------------ 1665
CACNA1D 1824 TRYYETYIRSDSG-DEQLPTICREDPEIHGYFRDPHCLGEQE 1864
CACNA1F 1724 --ALIFTIPEEGN-SQPKGTKGQNKQ------------DEDE 1750
CACNA1A 2131 -------G---PK-ARRLDDYSLERV------------PP-- 2147
CACNA1B 2027 -------AQ-RPR-GTHLCSTTPDRP------------PP-- 2045
CACNA1E 2025 -------RDKRSN-SSWLEEFSMERS------------S--- 2043
CACNA1G 2132 -----------RQAAIRTDSLDVQ------------------ 2144
CACNA1H 2119 ------------------------------------------ 2118
CACNA1I 2042 ------------------------------------------ 2041
SCN5A 2001 ------------------------------------------ 2000
SCN1A 2007 ------------------------------------------ 2006
SCN2A 1996 ------------------------------------------ 1995
SCN3A 1991 ------------------------------------------ 1990
SCN4A 1827 ------------------------------------------ 1826
SCN7A 1678 ------------------------------------------ 1677
SCN8A 1971 ------------------------------------------ 1970
SCN9A 1968 ------------------------------------------ 1967
SCN10A 1945 ------------------------------------------ 1944
SCN11A 1791 ------------------------------------------ 1790
cons 2983 3024
CACNA1C 1836 TYEVKMNHDTEACSEPSLLSTE------MLSY--------QD 1863
CACNA1S 1666 ---ANVAYGNSNHSNSHVFSSVHYEREFPEETET-------- 1696
CACNA1D 1865 YFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHH 1906
CACNA1F 1751 EVPDRLSYLDEQAGTPP-CSVL-------------------- 1771
CACNA1A 2148 -EENQRHHQ--R---RRDRSHRASERSLGRYTDVD---TGLG 2180
CACNA1B 2046 -SQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMD---GAPS 2083
CACNA1E 2044 -----ENTY--K---SRRRSYHSSLRLSAHRLNSD---SGHK 2072
CACNA1G 2145 -------GL--G---SREDLLAEVSGPSPPLARAY---SFWG 2171
CACNA1H 2119 ------------------------------------------ 2118
CACNA1I 2042 ------------------------------------------ 2041
SCN5A 2001 ------------------------------------------ 2000
SCN1A 2007 ------------------------------------------ 2006
SCN2A 1996 ------------------------------------------ 1995
SCN3A 1991 ------------------------------------------ 1990
SCN4A 1827 ------------------------------------------ 1826
SCN7A 1678 ------------------------------------------ 1677
SCN8A 1971 ------------------------------------------ 1970
SCN9A 1968 ------------------------------------------ 1967
SCN10A 1945 ------------------------------------------ 1944
SCN11A 1791 ------------------------------------------ 1790
cons 3025 3066
CACNA1C 1864 DENR--QLTLPEEDK---------RDIRQSPKRGFL-RSASL 1893
CACNA1S 1697 ---------------------------PATRGRALGQPCRVL 1711
CACNA1D 1907 PQGF--LEDDDSPVC---------YDSRRSPRRRLLPPT-PA 1936
CACNA1F 1772 ------LPPHRAQRY---------MDGHLVPRRRLLPPT-PA 1797
CACNA1A 2181 TDL---SMTTQSGDLP-----SKERDQERGRPKDRKHRQ-HH 2213
CACNA1B 2084 SAV---GPGLPPGEGPTGCRRERERRQERGRSQERRQPS-SS 2121
CACNA1E 2073 SDT------------------HRSGGRERGRSKERKHLL-SP 2095
CACNA1G 2172 QSSTQAQQHSRSHSK---------------ISKHMTPPA-PC 2197
CACNA1H 2119 --------------------------------------G-PE 2121
CACNA1I 2042 ------------------------------PRRALGPPA-PA 2052
SCN5A 2001 ------------------------------------------ 2000
SCN1A 2007 ------------------------------------------ 2006
SCN2A 1996 ------------------------------------------ 1995
SCN3A 1991 ------------------------------------------ 1990
SCN4A 1827 ------------------------------------------ 1826
SCN7A 1678 ------------------------------------------ 1677
SCN8A 1971 ------------------------------------------ 1970
SCN9A 1968 ------------------------------------------ 1967
SCN10A 1945 ------------------------------------------ 1944
SCN11A 1791 ------------------------------------------ 1790
cons 3067 3108
CACNA1C 1894 -GRRAS-----FHLECLKRQKDR-GGDIS-----QKTVLPLH 1923
CACNA1S 1712 -GPHSK-----PCVEMLKG----------------------- 1724
CACNA1D 1937 SHRRSS-----FNFECLRRQSSQ-EEVPSSPIFPHRTALPLH 1972
CACNA1F 1798 -GRKPS-----FTIQCLQRQGSC-EDLPIPGTY--------- 1823
CACNA1A 2214 HHHHHH-----HH----------------------------- 2221
CACNA1B 2122 SSEKQR-----FY-SC-----DRFGGREP-----PKPK--PS 2145
CACNA1E 2096 DVSRCN--------SE-----ER--GTQA-----DWES--PE 2115
CACNA1G 2198 PGPEPNWGKGPPETRS-----SL-ELDTE------------- 2220
CACNA1H 2122 ASPVAG-----GE----------------------------- 2129
CACNA1I 2053 PGPRAG-----LS----------------------------- 2060
SCN5A 2001 ------------------------------------------ 2000
SCN1A 2007 ------------------------------------------ 2006
SCN2A 1996 ------------------------------------------ 1995
SCN3A 1991 ------------------------------------------ 1990
SCN4A 1827 ------------------------------------------ 1826
SCN7A 1678 ------------------------------------------ 1677
SCN8A 1971 ------------------------------------------ 1970
SCN9A 1968 ------------------------------------------ 1967
SCN10A 1945 ------------------------------------------ 1944
SCN11A 1791 ------------------------------------------ 1790
cons 3109 3150
CACNA1C 1924 LVHHQALAVAGLSP--L----LQRSHSPASFPRPFATPPATP 1959
CACNA1S 1725 ------LLTQRAMP--R----GQAPPAPCQC----------- 1743
CACNA1D 1973 LMQQQIMAVAGLDS--S----KAQKYSPSHSTRSWATPPATP 2008
CACNA1F 1824 ----------------H----RGRNSGPNRAQGSWATPPQRG 1845
CACNA1A 2222 ----P--------------------PPPDKDRYAQ-ERPDHG 2238
CACNA1B 2146 LSSHPTSPTAGQEPGPHPQGSGSVNGSPLLSTSGASTPGRGG 2187
CACNA1E 2116 -RRQSRSPSEGRSQTPNRQGTGSLSESSIPSVSDTSTP-RRS 2155
CACNA1G 2221 -------L-----S--------------------WISGDLLP 2230
CACNA1H 2130 ------------------------------------------ 2129
CACNA1I 2061 ------------------------------------------ 2060
SCN5A 2001 ------------------------------------------ 2000
SCN1A 2007 ------------------------------------------ 2006
SCN2A 1996 ------------------------------------------ 1995
SCN3A 1991 ------------------------------------------ 1990
SCN4A 1827 ------------------------------------------ 1826
SCN7A 1678 ------------------------------------------ 1677
SCN8A 1971 ------------------------------------------ 1970
SCN9A 1968 ------------------------------------------ 1967
SCN10A 1945 ------------------------------------------ 1944
SCN11A 1791 ------------------------------------------ 1790
cons 3151 3192
CACNA1C 1960 GSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPG 2001
CACNA1S 1744 ----------P--RVESSMPEDRKSSTPGSLHE-----ETP- 1767
CACNA1D 2009 PYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP- 2049
CACNA1F 1846 -----RLLYAPLLLVEEGAAGEGYLGRS-------------- 1868
CACNA1A 2239 R---------------ARARDQRWS----------------- 2248
CACNA1B 2188 RRQLPQTPLTPRPSITYKTANSSPIHFAGAQ----------- 2218
CACNA1E 2156 RRQLPPVPPKPRPLLSYSSLIRHAGSISPPA----------- 2186
CACNA1G 2231 PGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAV 2272
CACNA1H 2130 ----------RDLRRLYSVDAQGFLDKP-GRADEQWRPSAEL 2160
CACNA1I 2061 ----------PAARRRLSLRGRGLFSLR-GLRAHQ-RSHSSG 2090
SCN5A 2001 ------------------LA---------------------- 2002
SCN1A 2007 ------------------------------------------ 2006
SCN2A 1996 ------------------------------------------ 1995
SCN3A 1991 ------------------------------------------ 1990
SCN4A 1827 ------------------------------------------ 1826
SCN7A 1678 ------------------------------------------ 1677
SCN8A 1971 ------------------------------------------ 1970
SCN9A 1968 ------------------------------------------ 1967
SCN10A 1945 ------------------EA---------------------- 1946
SCN11A 1791 ------------------------------------------ 1790
cons 3193 3234
CACNA1C 2002 GGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEA---- 2039
CACNA1S 1768 ---------------HSRSTRENTSRCSAPATALLIQK---- 1790
CACNA1D 2050 ---DISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEA---- 2084
CACNA1F 1869 ---SGPLRTFT--CLHVPGTHSDPSHGKRGSADSLVEA---- 1901
CACNA1A 2249 ------------------------------------------ 2248
CACNA1B 2219 ----T---------SLPAFSPGRLSRGLSEHNA-----LLQR 2242
CACNA1E 2187 ----D---------GSEEGSPLT-SQALESNNACLTESSNSP 2214
CACNA1G 2273 SCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPS---- 2310
CACNA1H 2161 GSGEPG-------EAKAWGPEAEPALGARRKKKMSPPC---- 2191
CACNA1I 2091 GSTSPG------------------------------------ 2096
SCN5A 2003 ------------------------------------------ 2002
SCN1A 2007 ------------------------------------------ 2006
SCN2A 1996 ------------------------------------------ 1995
SCN3A 1991 ------------------------------------------ 1990
SCN4A 1827 ------------------------------------------ 1826
SCN7A 1678 ------------------------------------------ 1677
SCN8A 1971 ------------------------------------------ 1970
SCN9A 1968 ------------------------------------------ 1967
SCN10A 1947 ------------------------------------------ 1946
SCN11A 1791 ------------------------------------------ 1790
cons 3235 3276
CACNA1C 2040 -VLISEGL----GQFAQDPK---------------------- 2054
CACNA1S 1791 -ALVRGGL----GTLAADAN---------------------- 1805
CACNA1D 2085 -VLISEGL----GRYARDPK---------------------- 2099
CACNA1F 1902 -VLISEGL----GLFARDPR---------------------- 1916
CACNA1A 2249 ------------------------------------------ 2248
CACNA1B 2243 DPLSQPLA----PGSRIGSD---------------------- 2258
CACNA1E 2215 HPQQSQHA----SPQRYISE---------------------- 2230
CACNA1G 2311 -ITIDPP----ESQGPRTPP---------------------- 2325
CACNA1H 2192 -ISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSL 2232
CACNA1I 2097 -----------------------------------CTHHDSM 2103
SCN5A 2003 ------------------------------------------ 2002
SCN1A 2007 ------------------------------------------ 2006
SCN2A 1996 ------------------------------------------ 1995
SCN3A 1991 ------------------------------------------ 1990
SCN4A 1827 ------------------------------------------ 1826
SCN7A 1678 ------------------------------------------ 1677
SCN8A 1971 ------------------------------------------ 1970
SCN9A 1968 ------------------------------------------ 1967
SCN10A 1947 ------------------------------------------ 1946
SCN11A 1791 ------------------------------------------ 1790
cons 3277 3318
CACNA1C 2055 -----------------------FIE---------------- 2057
CACNA1S 1806 -----------------------FIM---------------- 1808
CACNA1D 2100 -----------------------FVS---------------- 2102
CACNA1F 1917 -----------------------FVA---------------- 1919
CACNA1A 2249 ------------------------------------------ 2248
CACNA1B 2259 -----------------------PYL---------------- 2261
CACNA1E 2231 -----------------------PYL---------------- 2233
CACNA1G 2326 -----------------------SPG---------------- 2328
CACNA1H 2233 EPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLG 2274
CACNA1I 2104 DPSDEEGRGGAGGGGAGSEHS--ETLSSLSLTSLFCPPPPPP 2143
SCN5A 2003 ------------------------------------------ 2002
SCN1A 2007 ------------------------------------------ 2006
SCN2A 1996 ------------------------------------------ 1995
SCN3A 1991 ------------------------------------------ 1990
SCN4A 1827 ------------------------------------------ 1826
SCN7A 1678 ------------------------------------------ 1677
SCN8A 1971 ------------------------------------------ 1970
SCN9A 1968 ------------------------------------------ 1967
SCN10A 1947 ------------------------------------------ 1946
SCN11A 1791 ------------------------------------------ 1790
cons 3319 3360
CACNA1C 2058 -------VTT-QELADACDMTIEEMESAADNILSGGAPQSPN 2091
CACNA1S 1809 -------ATG-QALADACQMEPEEVEIMATELLKGREAPEGM 1842
CACNA1D 2103 -------ATK-HEIADACDLTIDEMESAASTLLNGNVRPRAN 2136
CACNA1F 1920 -------LAK-QEIADACRLTLDEMDNAASDLLAQGTSS--- 1950
CACNA1A 2249 ------------------------------------------ 2248
CACNA1B 2262 -------GQR-LDSEASVHALPEDTLTFEEAVATNSGRSSRT 2295
CACNA1E 2234 -------ALH-EDSHAS-DCGEEETLTFEAAVATSLGRSNTI 2266
CACNA1G 2329 -------ICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVL 2363
CACNA1H 2275 VPSGDPFLDGSHSVTPESRASS--SGAIVPLEPPESE-PPMP 2313
CACNA1I 2144 A----PGLTPARKFSSTSSLAAPGRPHAAALAHGLARSPSWA 2181
SCN5A 2003 ------------------------------------------ 2002
SCN1A 2007 ------------------------------------------ 2006
SCN2A 1996 ------------------------------------------ 1995
SCN3A 1991 ------------------------------------------ 1990
SCN4A 1827 ------------------------------------------ 1826
SCN7A 1678 ------------------------------------------ 1677
SCN8A 1971 ------------------------------------------ 1970
SCN9A 1968 ------------------------------------------ 1967
SCN10A 1947 ------------------------------------------ 1946
SCN11A 1791 ------------------------------------------ 1790
cons 3361 3402
CACNA1C 2092 GALLPFVNCRDAG----QDRAGGEEDA----GCVRARGRPSE 2125
CACNA1S 1843 ASSLGCLNLGS------------------------SLGSLDQ 1860
CACNA1D 2137 GDVGPLSHRQDYE----LQDFGPGYSD----EE-PDPGR-DE 2168
CACNA1F 1951 -----------------------LYSD----EE-SILSRFDE 1964
CACNA1A 2249 -----------------------------------------R 2249
CACNA1B 2296 SYVSSLTSQSHPL----RRVPNGYHCTLGLS----SGGR--A 2327
CACNA1E 2267 GSAPPLRHSW--------QMPNGHYRRRRRGGPGPGMMCGAV 2300
CACNA1G 2364 SLSGLSSDPADLD----------------------------- 2376
CACNA1H 2314 VGDPPEKRRGLYLTVPQCPLEK-------P----GSPSA--T 2342
CACNA1I 2182 ADRSKDPPGRAPLPMGLGPLAP---P---P----QPLPG--E 2211
SCN5A 2003 -----------------------------------------D 2003
SCN1A 2007 ------------------------------------------ 2006
SCN2A 1996 ------------------------------------------ 1995
SCN3A 1991 ------------------------------------------ 1990
SCN4A 1827 ------------------------------------------ 1826
SCN7A 1678 ------------------------------------------ 1677
SCN8A 1971 ------------------------------------------ 1970
SCN9A 1968 ------------------------------------------ 1967
SCN10A 1947 ------------------------------------------ 1946
SCN11A 1791 ------------------------------------------ 1790
cons 3403 3444
CACNA1C 2126 EELQDSRVYVSSL 2138
CACNA1S 1861 HQGSQETLIPPRL 1873
CACNA1D 2169 EDLADEMICITTL 2181
CACNA1F 1965 EDLGDEMACVHAL 1977
CACNA1A 2250 SPSEGREHMAHRQ 2262
CACNA1B 2328 RHSYHHPDQDHWC 2340
CACNA1E 2301 NNLLSDTEEDDKC 2313
CACNA1G 2377 ------------P 2377
CACNA1H 2343 PA-PG-GGADDPV 2353
CACNA1I 2212 LE-PGDAASKRKR 2223
SCN5A 2004 FPPSPDRDRESIV 2016
SCN1A 2007 ---KG-------K 2009
SCN2A 1996 ---KGKDIRESKK 2005
SCN3A 1991 ---KGKEVRENQK 2000
SCN4A 1827 ---VRPGVKESLV 1836
SCN7A 1678 --------IQSQI 1682
SCN8A 1971 ---RQKEVRESKC 1980
SCN9A 1968 ---KGKDSKESKK 1977
SCN10A 1947 ---TSMELIAPGP 1956
SCN11A 1791 ------------D 1791
cons 3445 3457
ANK2 Paralogue Multiple Sequence Alignment
T-COFFEE, Version_8.99(Thu Feb 17 19:24:49 CET 2011 - Revision 594)
Cedric Notredame
CPU TIME:17 sec.
SCORE=94
*
BAD AVG GOOD
*
ANK2 : 94
ANK1 : 97
ANK3 : 93
cons : 94
ANK2 1 MMNEDAAQKSDSGEKFNG----------SSQRRKRPKKSDSNASF 35
ANK1 1 MPYSVG-----------------------------FREADAATSF 16
ANK3 1 MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASY 45
cons 1 * . :::*: :*: 45
ANK2 36 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLV 80
ANK1 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMV 61
ANK3 46 LRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVV 90
cons 46 *****:*:*:*.:::::.*:*** *******.****:***** :* 90
ANK2 81 QELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA 125
ANK1 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 106
ANK3 91 SELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNA 135
cons 91 *** : ::::***********:**** ***: **. ***:** 135
ANK2 126 QSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170
ANK1 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
ANK3 136 QSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180
cons 136 ***:*************::***:**:***.*. ************ 180
ANK2 171 LQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 215
ANK1 152 LQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196
ANK3 181 LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQND 225
cons 181 *****::.*: *:: .***************:***::**:***** 225
ANK2 216 HNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 260
ANK1 197 PNPDVLSK--------TGFTPLHIAAHYENLNVAQLLLNRGASVN 233
ANK3 226 NNADVESK--------SGFTPLHIAAHYGNINVATLLLNRAAAVD 262
cons 226 *.** ** :*********** *:*** *****.*:*: 270
ANK2 261 FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 305
ANK1 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHC 278
ANK3 263 FTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHC 307
cons 271 **.:*.*****:**:***. **:******.:*::**:* ****** 315
ANK2 306 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350
ANK1 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
ANK3 308 GARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQL 352
cons 316 .**.** :: *:**::.**: ::*******:***:****::**: 360
ANK2 351 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395
ANK1 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
ANK3 353 LLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKA 397
cons 361 ***:.. :**:* *:**.*********::*:*:**** *:**::* 405
ANK2 396 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAF 440
ANK1 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASF 413
ANK3 398 LNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAF 442
cons 406 **************:::*****:* ****:*:*******:***:* 450
ANK2 441 MGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 485
ANK1 414 MGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
ANK3 443 MGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQ 487
cons 451 ***: ** *::.****:.:*:: **.******:*:.**.: *:: 495
ANK2 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530
ANK1 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
ANK3 488 DGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG 532
cons 496 : * *:*:*:::***** ::*:*::::*: **:: * *: *** * 540
ANK2 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575
ANK1 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548
ANK3 533 YTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGK 577
cons 541 :****::****: :.. **: *: : ***************. 585
ANK2 576 LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 620
ANK1 549 VRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
ANK3 578 LEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGA 622
cons 586 : **:***:: * .::***.********.*::* .:. *** :*. 630
ANK2 621 SPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP 665
ANK1 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTP 638
ANK3 623 SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIAS 667
cons 631 ***:.* ***********:**:::* :**:**..:* : **::. 675
ANK2 666 LHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710
ANK1 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPV 683
ANK3 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNV 712
cons 676 :***:****.:**:***.: ** ::..*****.***.***.:* * 720
ANK2 711 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 755
ANK1 684 ADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
ANK3 713 AEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN 757
cons 721 *::* ::*. ** *::***** *..****:*:*:***:: *.** 765
ANK2 756 AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI 800
ANK1 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAI 773
ANK3 758 AKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGI 802
cons 766 **** **:***********.*:.:**::.*.** : :*.*.*.* 810
ANK2 801 AKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDV 845
ANK1 774 AKRLGYISVTDVLKVVTDET-S-FVLVSDKHRMSFPETVDEILDV 816
ANK3 803 ARRLGYISVVDTLKIVTEET-MTTTTVTEKHKMNVPETMNEVLDM 846
cons 811 *:*******.*.**:**:*. . :::**::..***: *:**: 855
ANK2 846 SDEE---------------------GDDTMTGDGGEYLRPEDLKE 869
ANK1 817 SEDE---------------------GEELISFKAERR-DSRDVD- 838
ANK3 847 SDDEVRKANAPEMLSDGEYISDVEEGEDAMTGDTDKYLGPQDLKE 891
cons 856 *::* *:: :: . . ..*:. 900
ANK2 870 LGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHAS 914
ANK1 839 -------------------------EEKELLDFVPKLDQVVESPA 858
ANK3 892 LGDDSLPA------EGYMGFSL-GARSASLRSFSSDRSYTLNRSS 929
cons 901 .. .* .* .. . .:. .: 945
ANK2 915 YLRDSAVMDDSVVIPSHQVSTLAKEAERNSYR-LSWGTENLDNVA 958
ANK1 859 IPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNIS 903
ANK3 930 YARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVN 974
cons 946 * . : : :* ..: ::* : :* * .::. **: 990
ANK2 959 LSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTR 1003
ANK1 904 PVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTR 948
ANK3 975 LVSSPIHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTR 1019
cons 991 :**:*:*************:***.**:*:*::****.*:**** 1035
ANK2 1004 VTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEI 1048
ANK1 949 ITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEI 993
ANK3 1020 ITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEI 1064
cons 1036 :****** ::*:. **:.* ******:: :**:*****.****** 1080
ANK2 1049 PHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDE 1093
ANK1 994 PHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDE 1038
ANK3 1065 PHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDE 1109
cons 1081 ***.: :***:*******. **** :. * ::****** 1125
ANK2 1094 VLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVL 1138
ANK1 1039 ELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSL 1083
ANK3 1110 ELDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGIL 1154
cons 1126 *.* *:* ***:***** *** **.::**: *: : ****** * 1170
ANK2 1139 SSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATF 1183
ANK1 1084 KSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATF 1128
ANK3 1155 SSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVKKILGNKATF 1199
cons 1171 .*. ** *** ***.*:***:::.*****: .*:*.*:***:*** 1215
ANK2 1184 SPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDA-PTLRL 1227
ANK1 1129 SPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDT-TSLRL 1172
ANK3 1200 SPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLRL 1244
cons 1216 *****:********:** : **:* . : :. **: ..*** 1260
ANK2 1228 LCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCR 1272
ANK1 1173 LCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCP 1217
ANK3 1245 LCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCH 1289
cons 1261 ***: *** ********** *.: ::*..*********** ** 1305
ANK2 1273 QIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMT 1317
ANK1 1218 RTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMT 1262
ANK3 1290 QVLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMT 1334
cons 1306 : *:* :*: :*:*: .********:*** :** *. ***:*** 1350
ANK2 1318 DDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKS 1362
ANK1 1263 DDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKA 1307
ANK3 1335 DDKVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKG 1379
cons 1351 **********:*** *****:*:***** .::.: ***.*:.*. 1395
ANK2 1363 GQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGL 1407
ANK1 1308 AQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYED- 1351
ANK3 1380 GQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGL 1424
cons 1396 .*: * * :*:****.: :*:**:::** * ***:::. . .. 1440
ANK2 1408 VHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDE------- 1445
ANK1 1352 TQHILCHLNITMPPCAKGSGAE----------DRRRTPTPLALR- 1385
ANK3 1425 PQTAVCNLNITLPAHKKETESDQDDEIEK--TDRRQSFASLALRK 1467
cons 1441 : :*:****:* * : :: ..:. 1485
ANK2 1446 --------------------------------------------- 1445
ANK1 1386 -YSILSE-------------------------------------- 1391
ANK3 1468 RYSYLTEPGMIERSTGATRSLPTTYSYKPFFSTRPYQSWTTAPIT 1512
cons 1486 1530
ANK2 1446 --------------------------------------------- 1445
ANK1 1392 --------------------------------------------- 1391
ANK3 1513 VPGPAKSGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTLGAST 1557
cons 1531 1575
ANK2 1446 --------------------------------------------- 1445
ANK1 1392 --------------------------------------------- 1391
ANK3 1558 TSSVKSISDVASPIRSFRTMSSPIKTVVSQSPYNIQVSSGTLARA 1602
cons 1576 1620
ANK2 1446 ----------------TESTET----------------------- 1451
ANK1 1392 --------------------------------------------- 1391
ANK3 1603 PAVTEATPLKGLASNSTFSSRTSPVTTAGSLLERSSITMTPPASP 1647
cons 1621 1665
ANK2 1452 ----------SVLKSHLVNEVPVL--------------------- 1465
ANK1 1392 --------------------------------------------- 1391
ANK3 1648 KSNINMYSSSLPFKSIITSAAPLISSPLKSVVSPVKSAVDVISSA 1692
cons 1666 1710
ANK2 1466 --------------------------------------------- 1465
ANK1 1392 --------------------------------------------- 1391
ANK3 1693 KITMASSLSSPVKQMPGHAEVALVNGSISPLKYPSSSTLINGCKA 1737
cons 1711 1755
ANK2 1466 --------------------------------------------- 1465
ANK1 1392 --------------------------------------------- 1391
ANK3 1738 TATLQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFSPLRSYV 1782
cons 1756 1800
ANK2 1466 --------------------------------------------- 1465
ANK1 1392 --------------------------------------------- 1391
ANK3 1783 SAAPSAFQSLRTPSASALYTSLGSSISATTSSVTSSIITVPVYSV 1827
cons 1801 1845
ANK2 1466 --------------------------------------------- 1465
ANK1 1392 --------------------------------------------- 1391
ANK3 1828 VNVLPEPALKKLPDSNSFTKSAAALLSPIKTLTTETHPQPHFSRT 1872
cons 1846 1890
ANK2 1466 ------------------------ASPDLLSEVSEMKQDLIKMTA 1486
ANK1 1392 -----------------STPGSLSGT------------------- 1400
ANK3 1873 SSPVKSSLFLAPSALKLSTPSSLSSSQEILKDVAEMKEDLMRMTA 1917
cons 1891 .: 1935
ANK2 1487 ILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKVNE 1531
ANK1 1401 --------------------------------------------- 1400
ANK3 1918 ILQTDVPEEKPF--QPELPKEGRIDDEEPFKIVEKVKEDLVKVSE 1960
cons 1936 1980
ANK2 1532 ILRSGTCTRDESSVQSSRSERGLV-EEEWVIVSDEEIEEARQKAP 1575
ANK1 1401 --------------------------------------------- 1400
ANK3 1961 ILKKDVCVDNKGSPKSPKSDKGHSPEDDWIEFSSEEIREARQQAA 2005
cons 1981 2025
ANK2 1576 LEITEYPCVEVRIDKEIKGKVEKDS--TGLVNYLTDDLNTCVP-L 1617
ANK1 1401 --------------------------------------------- 1400
ANK3 2006 --ASQSPSLPERVQVKAKAASEKDYNLTKVIDYLTNDIGSSSLTN 2048
cons 2026 2070
ANK2 1618 PKEQLQTVQDKAGKKCEALAVGRSSEKEGKDIPPDETQSTQKQHK 1662
ANK1 1401 --------------------------------------------- 1400
ANK3 2049 LKY------------------------KFEDAKKDGEERQKRVLK 2069
cons 2071 2115
ANK2 1663 PSLGIKKPVRRKLKEKQKQKEEGLQASAEKAELKKGSSEESLGED 1707
ANK1 1401 --------------------------------------------- 1400
ANK3 2070 PAIALQE-------HKLKMPPASMRTSTSEKELCKMA-DSFFGTD 2106
cons 2116 2160
ANK2 1708 PGLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRS 1752
ANK1 1401 --------------------------------------------- 1400
ANK3 2107 TIL------------------------------ESPDDFSQHDQD 2121
cons 2161 2205
ANK2 1753 KLPIRVKGKEDVPKKTTHRPHPAASPSLKSERHAPGSPSPKTERH 1797
ANK1 1401 --------------------------------------------- 1400
ANK3 2122 KSPLSDSGFETRSEKTPSAPQSAESTGPKPLFHEVPIPPVITETR 2166
cons 2206 2250
ANK2 1798 STLSSSAKTERHPPVSPSSKTEKHSPVSPSAKTERHSPASSSSKT 1842
ANK1 1401 --------------------------------------------- 1400
ANK3 2167 TEVVHVIRS-YDPSAGDVPQTQPEEPVSPKPSP------------ 2198
cons 2251 2295
ANK2 1843 EKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSG 1887
ANK1 1401 --------------------------------------------- 1400
ANK3 2199 -------------------------------------------TF 2200
cons 2296 2340
ANK2 1888 -RTEKHPPVSP-GRTEKRLPVSPSGRTDKHQPVSTAGK-TEKHLP 1929
ANK1 1401 --------------------------------------------- 1400
ANK3 2201 MELEPKPTTSSIKEKVKAFQMKASSEEDDHNRVLSKGMRVKEETH 2245
cons 2341 2385
ANK2 1930 VSPSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHK 1974
ANK1 1401 --------------------------------------------- 1400
ANK3 2246 ITTTTRMVYHSPPGGEGASERIEETMSVHDIMKAFQSGRDPSKEL 2290
cons 2386 2430
ANK2 1975 TGLFEHKSAKQ--------------------KQPQEKGKVRVEKE 1999
ANK1 1401 --------------------------------------------- 1400
ANK3 2291 AGLFEHKSAVSPDVHKSAAETSAQHAEKDNQMKPKLERIIEVHIE 2335
cons 2431 2475
ANK2 2000 KGPILTQR-----EAQK---------------------------- 2011
ANK1 1401 --------------------------------------------- 1400
ANK3 2336 KGNQAEPTEVIIRETKKHPEKEMYVYQKDLSRGDINLKDFLPEKH 2380
cons 2476 2520
ANK2 2012 -----------TENQTIKRGQRLPVTGTAESKR------------ 2033
ANK1 1401 --------------------------------------------- 1400
ANK3 2381 DAFPCSEEQGQQEEEELTAEES----------LPSYLESSRVNTP 2415
cons 2521 2565
ANK2 2034 -----GVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVPEEESHR 2073
ANK1 1401 --------------------------------------------- 1400
ANK3 2416 VSQEEDSRPSSAQLISDDSYKTLKLLSQHSIEYHDDEL--SELRG 2458
cons 2566 2610
ANK2 2074 ESEVPKEKMADEQGDMDLQISPDRKTSTDFSEVIKQELEDNDKYQ 2118
ANK1 1401 --------------------------------------------- 1400
ANK3 2459 ESYRFAEKMLLSE-KLDVSHSDTEESVTDHAGPPSSELQGSDKRS 2502
cons 2611 2655
ANK2 2119 QFRLSEETEKAQL-------------------HLDQVL--TSPFN 2142
ANK1 1401 --------------------------------------------- 1400
ANK3 2503 REKIATAPKKEILSKIYKDVSENGVGKVSKDEHFDKVTVLHYSGN 2547
cons 2656 2700
ANK2 2143 TTFPLDYMKDEFLPALSLQSGALDGSSESLKNEGVAGSPCGSLME 2187
ANK1 1401 --------------------------------------------- 1400
ANK3 2548 VSSPKHAMW------MRFTEDRLDRGREKLIYEDRVDRTVKEAEE 2586
cons 2701 2745
ANK2 2188 GTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQTGETKEST 2232
ANK1 1401 --------------------------------------------- 1400
ANK3 2587 KLTEVSQFFRDKTEKLNDEL-QSPEKK-ARPKNGKEYSSQSPTSS 2629
cons 2746 2790
ANK2 2233 KTET--TTEIRSEKEHPTTKDITGGSEERGATVTEDSETSTESF- 2274
ANK1 1401 --------------------------------------------- 1400
ANK3 2630 SPEKVLLTELLASNDEW-VKARQHGPDGQGFPKAEEKAPSLPSSP 2673
cons 2791 2835
ANK2 2275 --------------------------------------------- 2274
ANK1 1401 --------------------------------------------- 1400
ANK3 2674 EKMVLSQQTEDSKSTVEAKGSISQSKAPDGPQSGFQLKQSKLSSI 2718
cons 2836 2880
ANK2 2275 --------------------------------------------- 2274
ANK1 1401 --------------------------------------------- 1400
ANK3 2719 RLKFEQGTHAKSKDMSQEDRKSDGQSRIPVKKIQESKLPVYQVFA 2763
cons 2881 2925
ANK2 2275 -----------------QKEATLGSPKD----------------- 2285
ANK1 1401 --------------------------------------------- 1400
ANK3 2764 REKQQKAIDLPDESVSVQKDFMVLKTKDEHAQSNEIVVNDSGSDN 2808
cons 2926 2970
ANK2 2286 --------------------------------------------- 2285
ANK1 1401 --------------------------------------------- 1400
ANK3 2809 VKKQRTEMSSKAMPDSFSEQQAKDLACHITSDLATRGPWDKKVFR 2853
cons 2971 3015
ANK2 2286 -------TSPKRQDDCTGSCSVALAKETPTGLTEEAACDEGQRTF 2323
ANK1 1401 --------------------------------------------- 1400
ANK3 2854 TWESSGATNNKSQKEKLSHVLVHDVRENHIGHPESKSVDQKNEFM 2898
cons 3016 3060
ANK2 2324 GSSAHK-----TQTDSEVQESTATSDETKALPLPEASVKTDTGTE 2363
ANK1 1401 --------------------------------------------- 1400
ANK3 2899 SVTERERKLLTNGSLSEIKEMTVKSPSKKVLY-REYVVKEG---- 2938
cons 3061 3105
ANK2 2364 SKPQGVIRSPQGLELALPSRDSEV--------------------- 2387
ANK1 1401 --------------------------------------------- 1400
ANK3 2939 D-------HPGGL-LDQPSRRSESSAVSHIPVRVADERRMLSSNI 2975
cons 3106 3150
ANK2 2388 --------------------LSAVADDSLAVSHKD---------- 2402
ANK1 1401 --------------------------------------------- 1400
ANK3 2976 PDGFCEQSAFPKHELSQKLSQSSMSKETVETQHFNSIEDEKVTYS 3020
cons 3151 3195
ANK2 2403 ----------SLEASPVLED--NSSHKTPDSLEPSPLKESPCRDS 2435
ANK1 1401 --------------------------------------------- 1400
ANK3 3021 EISKVSKHQSYVGLCPPLEETETSPTKSPDSLEFSPGKESPSSDV 3065
cons 3196 3240
ANK2 2436 LESSPVEPKMKAGIFPSHFPLPAAVAKTELLTEVAS--------- 2471
ANK1 1401 --------------------------------------------- 1400
ANK3 3066 FDHSPIDGLEKLA----------PLAQTEGGKEIKTLPVYVSFVQ 3100
cons 3241 3285
ANK2 2472 -----------------------------------VRSRLLRDPD 2481
ANK1 1401 --------------------------------------------- 1400
ANK3 3101 VGKQYEKEIQQGGVKKIISQECKTVQETRGTFYTTRQQKQPPSPQ 3145
cons 3286 3330
ANK2 2482 GSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDVS- 2525
ANK1 1401 --------------------------------------------- 1400
ANK3 3146 GSPEDDTLEQVSFLDSSGKSPLTPETPSSEEVSYEFTSKTPDSLI 3190
cons 3331 3375
ANK2 2526 -------TPKPAVIHECAEEDDSENGEKKRFTPEEEMFKMVTKIK 2563
ANK1 1401 --------------------------------------------- 1400
ANK3 3191 AYIPGKPSPIPEVSEESEEEEQAKSTSLKQTTVEETAV----ERE 3231
cons 3376 3420
ANK2 2564 MFDELEQEAKQKRDYKKEPKQEESSSSS-----DPDADCSVDVDE 2603
ANK1 1401 --------------------------------------------- 1400
ANK3 3232 MPNDVSKDS------NQRPKNNRVAYIEFPPPPPLDADQ-IESDK 3269
cons 3421 3465
ANK2 2604 PKHTGSGEDESGVPVLVTSESRKVSSSSESEPEL--AQLKKGADS 2646
ANK1 1401 --------------------------------------------- 1400
ANK3 3270 KHHY----------------------LPEKEVDMIEVNLQDEHDK 3292
cons 3466 3510
ANK2 2647 GLLPEPVIRVQPPSPLPSSMD-SNSSPEEVQFQPVVSKQYTFKMN 2690
ANK1 1401 --------------------------------------------- 1400
ANK3 3293 YQLAEPVIRVQPPSPVPPGADVSDSSDDESIYQPVPVKKYTFKLK 3337
cons 3511 3555
ANK2 2691 E--DTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRSYDKLNRDT 2733
ANK1 1401 --------------------------------------------- 1400
ANK3 3338 EVDDEQKEKPKASAEKASNQKELESNG----SGKDNEF-GLGLDS 3377
cons 3556 3600
ANK2 2734 DQPKICDGHGCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKES 2778
ANK1 1401 --------------------------------------------- 1400
ANK3 3378 PQNEIAQ--------------------------NGNNDQSITECS 3396
cons 3601 3645
ANK2 2779 LALQGTHEKDTEGEELDVSRAESPQADCPSESFSSSSSLPHCLVS 2823
ANK1 1401 --------------------------------------------- 1400
ANK3 3397 IATTAEFSHDTDATEIDSLDGYDLQDEDD-GLTESDSKLP----I 3436
cons 3646 3690
ANK2 2824 EGKELDEDISATSSIQKTEVTKTDETFENLPKDCPSQDSSITTQT 2868
ANK1 1401 --------------------------------------------- 1400
ANK3 3437 QAMEIKKDIWNTEGILKPA----DRSFSQ---------------- 3461
cons 3691 3735
ANK2 2869 DRFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFSSEESKTQT 2913
ANK1 1401 --------------------------------------------- 1400
ANK3 3462 ------------SKLEVIEEEGKVGPDEDKPPSKSSSSEKTPDKT 3494
cons 3736 3780
ANK2 2914 DANHTTSFHSSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQ 2958
ANK1 1401 --------------------------------------------- 1400
ANK3 3495 DQKSGAQFFTLEGR-----HPDRSVF------------------- 3515
cons 3781 3825
ANK2 2959 DIKMESQQESTLWEMQSDSVSSSFEPTMSATTTVVGEQIS---KV 3000
ANK1 1401 --------------------------------------------- 1400
ANK3 3516 -------------------------PDTYFSY-KVDEEFATPFKT 3534
cons 3826 3870
ANK2 3001 IITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDRQSQGT 3045
ANK1 1401 --------------------------------------------- 1400
ANK3 3535 VAT-KGLDFDPWSNNRGDDEVFDSKSREDETKPFGLAVEDRSPAT 3578
cons 3871 3915
ANK2 3046 TPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRS 3090
ANK1 1401 --------------------------------------------- 1400
ANK3 3579 TPDTTPARTPTDESTPTSEPNPFPFHEGKMFEMTRSGAIDMSKRD 3623
cons 3916 3960
ANK2 3091 YADESFHFFQIGQESREETLSEDVKEGAT---GADPLPL--ETSA 3130
ANK1 1401 --------------------------------------------- 1400
ANK3 3624 FVEERLQFFQIGEHTSE-GKSGDQGEGDKSMVTATPQPQSGDTTV 3667
cons 3961 4005
ANK2 3131 ESLALSESKETVDDEADL-LPDDVSEEVEEIPASDAQLN------ 3168
ANK1 1401 --------------------------------------------- 1400
ANK3 3668 ET-NLERNVETPTVEPNPSI--PTSGECQEGTSSSGSLEKSAAAT 3709
cons 4006 4050
ANK2 3169 ------------SQMGISASTETPTKEAVSVGTKDLPTVQTGDIP 3201
ANK1 1401 --------------------------------------------- 1400
ANK3 3710 NTSKVDPKLRTPIKMGISASTMTMKKEGPGEITDKIEAVMTSCQG 3754
cons 4051 4095
ANK2 3202 -PLSGVKQISCPDSSEPAVQVQLDFSTLTRSVYSDRGDDSPDSSP 3245
ANK1 1401 --------------------------------------------- 1400
ANK3 3755 LENETITMISNTANSQMGVRPHEKH---------DFQKDNFNNNN 3790
cons 4096 4140
ANK2 3246 EEQKSVIEIPTAPMENVPFTESKSKIPVRTMPTSTPAPPSAEYES 3290
ANK1 1401 --------------------------------------------- 1400
ANK3 3791 NLDSSTIQTD-NIMSNIVLTEHS--APTCTTEKDNPVKVSSGKKT 3832
cons 4141 4185
ANK2 3291 SVSE-----DFLSSVDEENKADE---AKPKSKLPVKVPLQRVEQQ 3327
ANK1 1401 --------------------------------------------- 1400
ANK3 3833 GVLQGHCVRDKQKVLGEQQKTKELIGIRQKSKLPIKATSPK---- 3873
cons 4186 4230
ANK2 3328 LSDLDTSVQKTVAP------QGQDMASIAPDNRSKSESDASSLDS 3366
ANK1 1401 --------------------------------------------- 1400
ANK3 3874 ---------DTFPPNHMSNTKASKMKQVSQSEKTKALTTSSCVDV 3909
cons 4231 4275
ANK2 3367 KTKCPVKTRSYTETETESRERAEELELESEEGATRPKILTSRLPV 3411
ANK1 1401 --------------------------------------------- 1400
ANK3 3910 KSRIPVKNTHRDNIIAVRKACATQKQGQPEKG--KAKQLPSKLPV 3952
cons 4276 4320
ANK2 3412 KSRSTTSSCRG-------------GTSP-TKESKEHFFDLYRNSI 3442
ANK1 1401 --------------------------------------------- 1400
ANK3 3953 KVRSTCVTTTTTTATTTTTTTTTTTTSCTVKVRKSQLKEVCKHSI 3997
cons 4321 4365
ANK2 3443 EFFEEISDEASKLVDRLTQSERE-QEIVSDDESSSALEVSVIENL 3486
ANK1 1401 --------------------------------------------- 1400
ANK3 3998 EYFKGISGETLKLVDRLSEEEKKMQSELSDEEESTSRNTSLSETS 4042
cons 4366 4410
ANK2 3487 ---PPVETEHSVPEDIFDTRPIWDESIETLIERIPDENGHDHAED 3528
ANK1 1401 --------------------------------------------- 1400
ANK3 4043 RGGQPSVTTKSARDKKTEAAPLKS-----KSEKAGSEKRSSRRTG 4082
cons 4411 4455
ANK2 3529 PQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENP 3573
ANK1 1401 -----EQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP 1440
ANK3 4083 PQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENP 4127
cons 4456 *: : ::* :::***:**:******:*: ::*::**:*** 4500
ANK2 3574 NSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMET 3618
ANK1 1441 NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEG 1485
ANK3 4128 NSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEG 4172
cons 4501 *** .** **: *: *:*::*. * * .*:* :** ::* 4545
ANK2 3619 N-TEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCT------- 3655
ANK1 1486 SGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCA 1530
ANK3 4173 P-I------------------------------------------ 4174
cons 4546 4590
ANK2 3656 ------------------------AQHKQKEEQAVSKESETCDHP 3676
ANK1 1531 LSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTP 1575
ANK3 4175 -----------------------------------------FDYG 4178
cons 4591 4635
ANK2 3677 PIVSEEDISVGYSTFQDG--------------------------- 3694
ANK1 1576 SLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL 1620
ANK3 4179 NISGTRSFADENNVFHDP--------------------------- 4196
cons 4636 : .. : . .* 4680
ANK2 3695 -----------------VPKTEGDSSATALFPQTHKEQVQQDFSG 3722
ANK1 1621 VEDDTVDSDATNGLIDLLEQEEGQRSEEKL-PGS---KRQDDATG 1661
ANK3 4197 -----------------VDGWQNETSSGNLESCAQARRVTGGLLD 4224
cons 4681 : :.: * * . : : . . 4725
ANK2 3723 KMQDLPEESSLEYQ------------------------------- 3736
ANK1 1662 AGQDSENEVSL-VSGHQRGQARITHSPTVSQVTERSQDRLQDWDA 1705
ANK3 4225 RLDDSPDQCRD-SI------------------------------- 4237
cons 4726 :* :: 4770
ANK2 3737 --------------------------------------------- 3736
ANK1 1706 DGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEY 1750
ANK3 4238 --------------------------------------------- 4237
cons 4771 4815
ANK2 3737 -------------------------------------------QE 3738
ANK1 1751 EKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQ 1795
ANK3 4238 -------------------------------------------TS 4239
cons 4816 . 4860
ANK2 3739 YFVTTPGTETSETQKAMIVPSSPSKT--PEEVSTPAEEEKLYLQT 3781
ANK1 1796 VVQGN--------EFQNIPGEQVTEEQFTDEQGNI---------- 1822
ANK3 4240 YLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVGKQS---TKE 4281
cons 4861 . . * . :: .:. . 4905
ANK2 3782 PTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETC 3826
ANK1 1823 --------------------------------------------- 1822
ANK3 4282 TLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKPCVPV-- 4324
cons 4906 4950
ANK2 3827 ERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKII 3871
ANK1 1823 -----------------------------------VTKKIIRKVV 1832
ANK3 4325 -----------------------------------SMK----KMS 4330
cons 4951 * *: 4995
ANK2 3872 RRY--VSSE-GTE---KEEIMVQGMPQEPVNIEEGDGYSKVIK-- 3908
ANK1 1833 RQIDLSSADAAQE---HEEVELRGSGLQPDL-IEGRKGAQIVK-- 1871
ANK3 4331 -RT--SPADGKPRLSLHEEEGSSGSEQ-----KQGEGFKVKTKKE 4367
cons 4996 : .:: . :** * :* * 5040
ANK2 3909 -RVVLKSDTEQSEDNNE 3924
ANK1 1872 -RAS-------LKRGKQ 1880
ANK3 4368 IRHV-------EKKSHS 4377
cons 5041 * : .:. 5057
KCNE1/KCNE2 Paralogue Multiple Sequence Alignment
T-COFFEE, Version_8.99(Thu Feb 17 19:24:49 CET 2011 - Revision 594)
Cedric Notredame
CPU TIME:0 sec.
SCORE=63
*
BAD AVG GOOD
*
KCNE1 : 66
KCNE2 : 63
KCNE3 : 60
KCNE4 : 64
cons : 63
KCNE1 1 ---MILSN-T---TAVTP-FLTK---------LWQETV------Q 22
KCNE2 1 ---MSTLSNF---TQTLEDVFRR---------IFIT-YMDNWRQN 29
KCNE3 1 ---METTNGTETWYESLHAVLKALNATLHSNLLCRPGP------G 36
KCNE4 1 MLKMEPLNST---H-----------------------P------G 13
cons 1 * . 45
KCNE1 23 QGGN-MSGLARR-SPRSSDGKLEA---LYVLMVLGFFGFFTLGIM 62
KCNE2 30 TTAEQEALQ------AKVDAENFYYVILYLMVMIGMFSFIIVAIL 68
KCNE3 37 LGPD-NQTEERRASLPGR-DDNSY---MYILFVMFLFAVTVGSLI 76
KCNE4 14 TAASSSPLESRA-AGGGSGNGNEY---FYILVVMSFYGIFLIGIM 54
cons 46 . :*::.:: ::.. .:: 90
KCNE1 63 LSYIRSKKLEHSNDPFNVYIESDA-WQEKDKAYVQARVLESYR-- 104
KCNE2 69 VSTVKSKRREHSNDPYHQYIVED--WQEKYKSQILNL-------- 103
KCNE3 77 LGYTRSRKVDKRSDPYHVYIKN----------------------- 98
KCNE4 55 LGYMKSKRREKKSSLLLLYKDEERLWGEAMKPLPVVSGLRSVQVP 99
cons 91 :. :*:: :: .. * . 135
KCNE1 105 --------------SCYVV---------EN-----HLAIEQP--N 119
KCNE2 104 ----------------------------EE-----SKATIHE--N 113
KCNE3 99 -----------------------------------RVSM------ 102
KCNE4 100 LMLNMLQESVAPALSCTLCSMEGDSVSSESSSPDVHLTIQEEGAD 144
cons 136 : 180
KCNE1 120 THLPETKPS----------------P 129
KCNE2 114 IGAAGFKMS----------------P 123
KCNE3 103 -------------------------I 103
KCNE4 145 DELEETSETPLNESSEGSSENIHQNS 170
cons 181 206
KCNJ2 Paralogue Multiple Sequence Alignment
T-COFFEE, Version_8.99(Thu Feb 17 19:24:49 CET 2011 - Revision 594)
Cedric Notredame
CPU TIME:1 sec.
SCORE=82
*
BAD AVG GOOD
*
KCNJ2 : 80
KCNJ5 : 81
KCNJ1 : 81
KCNJ12 : 78
KCNJ4 : 80
KCNJ14 : 79
KCNJ3 : 78
KCNJ6 : 81
KCNJ9 : 84
KCNJ10 : 86
KCNJ15 : 83
KCNJ16 : 79
KCNJ8 : 80
KCNJ11 : 83
KCNJ13 : 89
cons : 82
KCNJ2 1 -MGSVR-------------TNRYSIV--SSEEDGM--KLATM 24
KCNJ5 1 MAGDSR--------NAMNQDMEIGVT--PWDPKKIPKQARDY 32
KCNJ1 1 MNASSR-------------NVFDTLIRVLTESMFK--HLRKW 27
KCNJ12 1 MTAASR-------------ANPYSIV--SSEEDGL--HLVTM 25
KCNJ4 1 MHGHSR------------------------------------ 6
KCNJ14 1 -MGLARALRRL---SGALDSGDSRAG--DEEEAGP--GLCRN 34
KCNJ3 1 MSALRRK---------FGDDYQVVTT--SSSGS----GLQPQ 27
KCNJ6 1 MAKLTESMTNVLEGDSMDQDVESPVA--IHQP-KLPKQARDD 39
KCNJ9 1 --------------------MAQENA--AFSP---------- 10
KCNJ10 1 -MTSVA-------------KVYYSQT--TQTES--------- 17
KCNJ15 1 --MDAI-------------HIGMSST--PLVKH--------- 16
KCNJ16 1 --MSYY-------------GSSYHII--NADAKYP------- 18
KCNJ8 1 MLARKS-----------IIPEEYVLA--RIAA------EN-- 21
KCNJ11 1 MLSRKG-----------IIPEEYVLT--RLA-------ED-- 20
KCNJ13 1 ----------------------------MDSSNCK--VIAPL 12
cons 1 42
KCNJ2 25 AVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQ 66
KCNJ5 33 V--PIATDRTRLLAEGKKPRQRYMEKSGKCNVHHGNVQ-ETY 71
KCNJ1 28 V--V----T-R-FFGHSRQRARLVSKDGRCNIEFGNVEA-QS 60
KCNJ12 26 SGANGFGNGK--VHTRRRCRNRFVKKNGQCNIEFANMDEKSQ 65
KCNJ4 7 -------NGQAHVP-RRKRRNRFVKKNGQCNVYFANLSNKSQ 40
KCNJ14 35 GWAPAPVQS----P-VGRRRGRFVKKDGHCNVRFVNLGGQGA 71
KCNJ3 28 G--PGQ-DPQQQLV-PKKKRQRFVDKNGRCNVQHGNLGSETS 65
KCNJ6 40 L--PRHISRDR----TKRKIQRYVRKDGKCNVHHGNVR-ETY 74
KCNJ9 11 --------GQE-EPPRRRGRQRYVEKDGRCNVQQGNVR-ETY 42
KCNJ10 18 --------R-P-LMGPGIRRRRVLTKDGRSNVRMEHIADKRF 49
KCNJ15 17 --------T-A-GAGLKANRPRVMSKSGHSNVRIDKVDGIYL 48
KCNJ16 19 ----GYPPEH-IIAEKRRARRRLLHKDGSCNVYFKHIFGEWG 55
KCNJ8 22 L-------RKP-RIRDRLPKARFIAKSGACNLAHKNIR-EQG 54
KCNJ11 21 P-------AKP-RYRARQRRARFVSKKGNCNVAHKNIR-EQG 53
KCNJ13 13 L---------------SQRYRRMVTKDGHSTLQMDGAQR-GL 38
cons 43 * : *.* ..: 84
KCNJ2 67 --RYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLI 106
KCNJ5 72 --RYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLI 111
KCNJ1 61 RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAV 102
KCNJ12 66 --RYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVI 105
KCNJ4 41 --RYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCI 80
KCNJ14 72 --RYLSDLFTTCVDVRWRWMCLLFSCSFLASWLLFGLAFWLI 111
KCNJ3 66 --RYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVI 105
KCNJ6 75 --RYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLI 114
KCNJ9 43 --RYLTDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLI 82
KCNJ10 50 --LYLKDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLV 89
KCNJ15 49 --LYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVIYYAI 88
KCNJ16 56 --SYVVDIFTTLVDTKWRHMFVIFSLSYILSWLIFGSVFWLI 95
KCNJ8 55 --RFLQDIFTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLV 94
KCNJ11 54 --RFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLI 93
KCNJ13 39 --AYLRDAWGILMDMRWRWMMLVFSASFVVHWLVFAVLWYVL 78
cons 85 :. * : :* :* .* : *:.:. :: : 126
KCNJ2 107 ALLHGDLDAS------------------KEGKACVSEVNSFT 130
KCNJ5 112 AYIRGDLDHVG----------D------QEWIPCVENLSGFV 137
KCNJ1 103 AYIHKDLPEF--H--------P-----SANHTPCVENINGLT 129
KCNJ12 106 AVAHGDLEPAE-------G---------RGRTPCVMQVHGFM 131
KCNJ4 81 AFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNGFL 122
KCNJ14 112 ASLHGDLAAPP------------------PPAPCFSHVASFL 135
KCNJ3 106 AYTRGDLNKAH----------V------GNYTPCVANVYNFP 131
KCNJ6 115 AYIRGDMDHIE----------D------PSWTPCVTNLNGFV 140
KCNJ9 83 AYGRGDLEHLE----------D------TAWTPCVNNLNGFV 108
KCNJ10 90 AVAHGDLLEL--D--------P-----PANHTPCVVQVHTLT 116
KCNJ15 89 AFIHGDLEPG--E--------P-----ISNHTPCIMKVDSLT 115
KCNJ16 96 AFHHGDLLNDP------------------DITPCVDNVHSFT 119
KCNJ8 95 AFAHGDIYAYME--------KSGMEKSGLESTVCVTNVRSFT 128
KCNJ11 94 AFAHGDLAP--S---------E----GTA--EPCVTSIHSFS 118
KCNJ13 79 AEMNGDLELDHDA--------P-----PENHTICVKYITSFT 107
cons 127 * . *: *. : : 168
KCNJ2 131 AAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIID 172
KCNJ5 138 SAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVN 179
KCNJ1 130 SAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIIN 171
KCNJ12 132 AAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIID 173
KCNJ4 123 GAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVID 164
KCNJ14 136 AAFLFALETQTSIGYGVRSVTEECPAAVAAVVLQCIAGCVLD 177
KCNJ3 132 SAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVD 173
KCNJ6 141 SAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVN 182
KCNJ9 109 AAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVN 150
KCNJ10 117 GAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILE 158
KCNJ15 116 GAFLFSLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIE 157
KCNJ16 120 GAFLFSLETQTTIGYGYRCVTEECSVAVLMVILQSILSCIIN 161
KCNJ8 129 SAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQNIVGLIIN 170
KCNJ11 119 SAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMIN 160
KCNJ13 108 AAFSFSLETQLTIGYGTMFPSGDCPSAIALLAIQMLLGLMLE 149
cons 169 .** * :* : :**:* : .*. .: . * : ::: 210
KCNJ2 173 AFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRV 214
KCNJ5 180 AFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRV 221
KCNJ1 172 SFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRV 213
KCNJ12 174 SFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRV 215
KCNJ4 165 SFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRV 206
KCNJ14 178 AFVVGAVMAKMAKPKKRNETLVFSENAVVALRDHRLCLMWRV 219
KCNJ3 174 AFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRV 215
KCNJ6 183 AFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRV 224
KCNJ9 151 AFMVGCMFVKISQPNKRAATLVFSSHAVVSLRDGRLCLMFRV 192
KCNJ10 159 IFITGTFLAKIARPKKRAETIRFSQHAVVASHNGKPCLMIRV 200
KCNJ15 158 IFITGTFLAKIARPKKRAETIKFSHCAVITKQNGKLCLVIQV 199
KCNJ16 162 TFIIGAALAKMATARKRAQTIRFSYFALIGMRDGKLCLMWRI 203
KCNJ8 171 AVMLGCIFMKTAQAHRRAETLIFSRHAVIAVRNGKLCFMFRV 212
KCNJ11 161 AIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRV 202
KCNJ13 150 AFITGAFVAKIARPKNRAFSIRFTDTAVVAHMDGKPNLIFQV 191
cons 211 .: * . * : ...* :: *: *:: : :: :: 252
KCNJ2 215 GNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFD- 255
KCNJ5 222 GDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFD- 262
KCNJ1 214 ANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVD- 254
KCNJ12 216 GNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFD- 256
KCNJ4 207 GNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYD- 247
KCNJ14 220 GNLRRSHLVEAHVRAQLLQPRVTPEGEYIPLDHQDVDVGFD- 260
KCNJ3 216 GNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFS- 256
KCNJ6 225 GDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYY- 265
KCNJ9 193 GDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTDLSVGFD- 233
KCNJ10 201 ANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQVD- 241
KCNJ15 200 ANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVD- 240
KCNJ16 204 GDFRPNHVVEGTVRAQLLRYTEDSEGRM-TMAFKDLKLV--- 241
KCNJ8 213 GDLRKSMIISASVRIQVVKKTTTPEGEVVPIHQLDIPVDNP- 253
KCNJ11 203 GDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENG- 243
KCNJ13 192 ANTRPSPLTSVRVSAVLYQERENGK----L-YQTSVDFHLDG 228
cons 253 .: * . : : : : : : . 294
KCNJ2 256 -SGIDRIFLVSPITIVHEIDEDSPLYDLSKQDID-NADFEIV 295
KCNJ5 263 -TGDDRLFLVSPLIISHEINQKSPFWEMSQAQLH-QEEFEVV 302
KCNJ1 255 -AGNENLFFISPLTIYHVIDHNSPFFHMAAETLL-QQDFELV 294
KCNJ12 257 -KGLDRIFLVSPITILHEIDEASPLFGISRQDLE-TDDFEIV 296
KCNJ4 248 -IGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELE-SEDFEIV 287
KCNJ14 261 -GGTDRIFLVSPITIVHEIDSASPLYELGRAELA-RADFELV 300
KCNJ3 257 -TGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQ-TEQFEIV 296
KCNJ6 266 -TGDDRLFLVSPLIISHEINQQSPFWEISKAQLP-KEELEIV 305
KCNJ9 234 -TGDDRLFLVSPLVISHEIDAASPFWEASRRALE-RDDFEIV 273
KCNJ10 242 -TASDSPFLILPLTFYHVVDETSPLKDLPLRSG--EGDFELV 280
KCNJ15 241 -SSSESPFLILPMTFYHVLDETSPLRDLTPQNLK-EKEFELV 280
KCNJ16 242 ---NDQIILVTPVTIVHEIDHESPLYALDRKAVA-KDNFEIL 279
KCNJ8 254 -IESNNIFLVAPLIICHVIDKRSPLYDISATDLA-NQDLEVI 293
KCNJ11 244 -VGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEII 284
KCNJ13 229 ISSDECPFFIFPLTYYHSITPSSPLATLLQHE-N-PSHFELV 268
cons 295 : ::: *: * : **: .:*:: 336
KCNJ2 296 VILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEE-KHY 336
KCNJ5 303 VILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLE-KGF 343
KCNJ1 295 VFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGK 336
KCNJ12 297 VILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEE-KNQ 337
KCNJ4 288 VILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEE-KSH 328
KCNJ14 301 VILEGMVEATAMTTQCRSSYLPGELLWGHRFEPVLFQR-GSQ 341
KCNJ3 297 VILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLE-EGF 337
KCNJ6 306 VILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLE-DGF 346
KCNJ9 274 VILEGMVEATGMTCQARSSYLVDEVLWGHRFTSVLTLE-DGF 314
KCNJ10 281 LILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGK 322
KCNJ15 281 VLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLSKNGK 322
KCNJ16 280 VTFIYTGDSTGTSHQSRSSYVPREILWGHRFNDVLEVK-RKY 320
KCNJ8 294 VILEGVVETTGITTQARTSYIAEEIQWGHRFVSIVTEE-EGV 334
KCNJ11 285 VILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEE-DGR 325
KCNJ13 269 VFLSAMQEGTGEICQRRTSYLPSEIMLHHCFASLLTRGSKGE 310
cons 337 : : : *. * *:** *: : : 378
KCNJ2 337 YKVDYSRFHKTYEVPNTPL----CSARDLAEK----KYILSN 370
KCNJ5 344 YEVDYNTFHDTYETN-TPS----CCAKELAEMKREGRLLQYL 380
KCNJ1 337 YRVDFHNFSKTVEVET-PH----CAMCLYNEKDVR------- 366
KCNJ12 338 YKIDYSHFHKTYEVPSTPR----CSAKDLVEN----KFLLPS 371
KCNJ4 329 YKVDYSRFHKTYEVAGTPC----CSARELQES----KITVLP 362
KCNJ14 342 YEVDYRHFHRTYEVPGTPV----CSAKELDERAEQASHSLKS 379
KCNJ3 338 FKVDYSQFHATFEVP-TPP----YSVKEQEEMLLMSSPLIAP 374
KCNJ6 347 YEVDYNSFHETYETS-TPS----LSAKELAELASRAELPLSW 383
KCNJ9 315 YEVDYASFHETFEVP-TPS----CSARELAEAAARLDAHLYW 351
KCNJ10 323 YIADFSLFDQVVKVAS-PSGLRDSTVRYGDPEKLK------- 356
KCNJ15 323 YVADFSQFEQIRKSP---D----CTFYCADSEKQQ------- 350
KCNJ16 321 YKVNCLQFEGSVEVY-APF----CSAKQLDWK----DQQLHI 353
KCNJ8 335 YSVDYSKFGNTVKVA-APR----CSARELDEKPSILIQTLQK 371
KCNJ11 326 YSVDYSKFGNTVKVP-TPL----CTARQLDEDHSLLEALTLA 362
KCNJ13 311 YQIKMENFDKTVPEFPTPL----VS-KSP---NRT------- 337
cons 379 : . * 420
KCNJ2 371 A-----NSFCYENEV----ALTSKEEDDSENGVP------ES 397
KCNJ5 381 P-SPPLLGGCAEAGL---DAEAE----Q-------------- 400
KCNJ1 367 -------------------ARMK--RG-YDN----------- 375
KCNJ12 372 A-----NSFCYENEL----AFLSRDEEDEADGDQ------DG 398
KCNJ4 363 APPPPPSAFCYENEL----ALMSQEEEEMEEEAAAAAAVAAG 400
KCNJ14 380 SFPGSLTAFCYENEL----ALSCCQEEDEDDETE------EG 411
KCNJ3 375 A-ITNSKERHNSVEC---LDGLDDITTKLPSKLQ------KI 406
KCNJ6 384 S-VSSKLNQHAELET---EEEEK----N-------------- 403
KCNJ9 352 S-IPSRLDEKVEEEG---AGEGA----G-------------- 371
KCNJ10 357 ------------------LEESL--R---EQ----------- 364
KCNJ15 351 ------------------LEEKY--RQ-EDQ----------- 360
KCNJ16 354 EKAPPVRESCTSDTKARRRSFSAVAIVSSCENP-------EE 388
KCNJ8 372 SELS-H-----QNSL----RKRNSMRRNNSMRRNN------S 397
KCNJ11 363 S----A-----RGPL----RKRS------------------- 372
KCNJ13 338 -------------------DLDIHINGQSID----------- 349
cons 421 462
KCNJ2 398 TS-----TDT-------------------------------- 402
KCNJ5 401 -------------------------------N-EEDEPK--- 407
KCNJ1 376 ------------------------------------------ 375
KCNJ12 399 RS-----RDG-------------------------------- 403
KCNJ4 401 LGLEAGSKEE-------------------------------- 410
KCNJ14 412 NG-----VET-------------------------------- 416
KCNJ3 407 TG-----REDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSV 443
KCNJ6 404 -------------------------------LEEQTERN--- 411
KCNJ9 372 -----------------------------GEAGADKEQN--- 381
KCNJ10 365 ------------------------------------------ 364
KCNJ15 361 ------------------------------------------ 360
KCNJ16 389 TT-----TSA-------------------------------- 393
KCNJ8 398 IR-----RN--------------------------------- 401
KCNJ11 373 ------------------------------------------ 372
KCNJ13 350 ------------------------------------------ 349
cons 463 504
KCNJ2 403 ---------------------------PPDIDL------HNQ 411
KCNJ5 408 ---------------------------------GLGGSR--- 413
KCNJ1 376 ------------------------------------------ 375
KCNJ12 404 ----------------------LSPQARHDFDR------LQA 417
KCNJ4 411 ------AGI----------IRMLEFGSHLDLE-------RMQ 429
KCNJ14 417 ----------------------EDG----------------A 420
KCNJ3 444 PGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGAARME 485
KCNJ6 412 ---------------------------------GDVANL--- 417
KCNJ9 382 ---------------------------------GCLPPP--- 387
KCNJ10 365 ------------------------------------------ 364
KCNJ15 361 ------------------------------------------ 360
KCNJ16 394 ---------------------------THEYRE------TPY 402
KCNJ8 402 -----------------------------NSS------LMVP 408
KCNJ11 373 ----------------------------------------VP 374
KCNJ13 350 ------------------------------------------ 349
cons 505 546
KCNJ2 412 ASVPLEPRPLRRESEI 427
KCNJ5 414 ----------EARGSV 419
KCNJ1 376 PNFILSEVNETDDTKM 391
KCNJ12 418 GGGVLEQRPYRRESEI 433
KCNJ4 430 ASLPLDNISYRRESAI 445
KCNJ14 421 ASPRVLTPTLALTLPP 436
KCNJ3 486 GNLPAKLRKMNSDRFT 501
KCNJ6 418 ----------ENESKV 423
KCNJ9 388 ----------ESESKV 393
KCNJ10 365 AEKEGSALSVRISN-V 379
KCNJ15 361 RERELRTLLLQQSN-V 375
KCNJ16 403 QKALLTLNRISVESQM 418
KCNJ8 409 KVQFMTPEGNQNTSES 424
KCNJ11 375 MAKAKPKFSISPDSLS 390
KCNJ13 350 -NFQISETGLT----E 360
cons 547 562