{"text_format":"2","workbook":"xlsx","n_sheets":3,"sheets":["MGS - elevated in CD","MGS - depleted in CD","MetaHIT - elevated in CD"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":6,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"MGS - elevated in CD","index":0,"n_rows":33,"n_cols":3,"rows_kept":33,"cut":false,"hidden":false,"merged":[]}
["Module","q value","Description"]
["M00080",0.00235,"Lipopolysaccharide biosynthesis, inner core => outer core => O-antigen"]
["M00122",0.00235,"Cobalamin biosynthesis, cobinamide => cobalamin"]
["M00159",0.00235,"V-type ATPase, prokaryotes"]
["M00550",0.00235,"Ascorbate degradation, ascorbate => D-xylulose-5P"]
["M00116",0.00652,"Menaquinone biosynthesis, chorismate => menaquinone"]
["M00324",0.00652,"Dipeptide transport system"]
["M00008",0.09703,"Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate"]
["M00124",0.09703,"Pyridoxal biosynthesis, erythrose-4P => pyridoxal-5P"]
["M00194",0.09703,"Maltose/maltodextrin transport system"]
["M00546",0.14247,"Purine degradation, xanthine => urea"]
["M00053",0.20756,"Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP"]
["M00176",0.20756,"Assimilatory sulfate reduction, sulfate => H2S"]
[]
["Pathway","q value","Description"]
["ko02060",1.03E-011,"Phosphotransferase system (PTS)"]
["ko02020",1.66E-007,"Two-component system"]
["ko00051",0.00083,"Fructose and mannose metabolism"]
["ko00053",0.00364,"Ascorbate and aldarate metabolism"]
["ko01120",0.00667,"Microbial metabolism in diverse environments"]
["ko00540",0.00679,"Lipopolysaccharide biosynthesis"]
["ko02010",0.0147,"ABC transporters"]
["ko01100",0.0295,"Metabolic pathways"]
["ko00040",0.0506,"Pentose and glucuronate interconversions"]
["ko00780",0.0565,"Biotin metabolism"]
["ko00130",0.0637,"Ubiquinone and other terpenoid-quinone biosynthesis"]
["ko00860",0.0713,"Porphyrin and chlorophyll metabolism"]
["ko00511",0.0743,"Other glycan degradation"]
["ko00052",0.103,"Galactose metabolism"]
["ko00440",0.108,"Phosphonate and phosphinate metabolism"]
["ko00480",0.175,"Glutathione metabolism"]
["ko00330",0.202,"Arginine and proline metabolism"]
["ko01053",0.243,"Biosynthesis of siderophore group nonribosomal peptides"]

{"sheet":"MGS - depleted in CD","index":1,"n_rows":100,"n_cols":3,"rows_kept":100,"cut":false,"hidden":false,"merged":[]}
["Module","q value","Description"]
["M00359",0.00175,"Aminoacyl-tRNA biosynthesis, eukaryotes"]
["M00177",0.00237,"Ribosome, eukaryotes"]
["M00179",0.00439,"Ribosome, archaea"]
["M00360",0.00439,"Aminoacyl-tRNA biosynthesis, prokaryotes"]
["M00567",0.00797,"Methanogenesis, CO2 => methane"]
["M00296",0.1805,"BER complex"]
[]
["Pathway","q value","Description"]
["ko03460",5.84E-005,"Fanconi anemia pathway"]
["ko05206",0.000201,"MicroRNAs in cancer"]
["ko04144",0.000981,"Endocytosis"]
["ko05200",0.000981,"Pathways in cancer"]
["ko03010",0.00124,"Ribosome"]
["ko04012",0.00124,"ErbB signaling pathway"]
["ko04390",0.00124,"Hippo signaling pathway"]
["ko00970",0.00394,"Aminoacyl-tRNA biosynthesis"]
["ko04020",0.00394,"Calcium signaling pathway"]
["ko03040",0.00609,"Spliceosome"]
["ko05203",0.00621,"Viral carcinogenesis"]
["ko04330",0.0131,"Notch signaling pathway"]
["ko05217",0.0131,"Basal cell carcinoma"]
["ko04310",0.0134,"Wnt signaling pathway"]
["ko03008",0.021,"Ribosome biogenesis in eukaryotes"]
["ko03013",0.021,"RNA transport"]
["ko04974",0.021,"Protein digestion and absorption"]
["ko04340",0.0212,"Hedgehog signaling pathway"]
["ko04512",0.0212,"ECM-receptor interaction"]
["ko04666",0.0212,"Fc gamma R-mediated phagocytosis"]
["ko04510",0.0217,"Focal adhesion"]
["ko04320",0.0218,"Dorso-ventral axis formation"]
["ko04360",0.0218,"Axon guidance"]
["ko05213",0.0218,"Endometrial cancer"]
["ko04910",0.0258,"Insulin signaling pathway"]
["ko05161",0.0258,"Hepatitis B"]
["ko05322",0.0258,"Systemic lupus erythematosus"]
["ko04391",0.0302,"Hippo signaling pathway - fly"]
["ko04722",0.0302,"Neurotrophin signaling pathway"]
["ko05164",0.0311,"Influenza A"]
["ko04610",0.0322,"Complement and coagulation cascades"]
["ko05223",0.0322,"Non-small cell lung cancer"]
["ko03022",0.0343,"Basal transcription factors"]
["ko05205",0.0343,"Proteoglycans in cancer"]
["ko04151",0.0392,"PI3K-Akt signaling pathway"]
["ko04668",0.0398,"TNF signaling pathway"]
["ko05100",0.0398,"Bacterial invasion of epithelial cells"]
["ko05168",0.0455,"Herpes simplex infection"]
["ko04010",0.0467,"MAPK signaling pathway"]
["ko04520",0.0467,"Adherens junction"]
["ko04721",0.0467,"Synaptic vesicle cycle"]
["ko04141",0.0521,"Protein processing in endoplasmic reticulum"]
["ko04066",0.0622,"HIF-1 signaling pathway"]
["ko04145",0.0672,"Phagosome"]
["ko05146",0.0672,"Amoebiasis"]
["ko04011",0.0801,"MAPK signaling pathway - yeast"]
["ko04080",0.0801,"Neuroactive ligand-receptor interaction"]
["ko04120",0.0801,"Ubiquitin mediated proteolysis"]
["ko04917",0.0801,"Prolactin signaling pathway"]
["ko04930",0.0801,"Type II diabetes mellitus"]
["ko05032",0.0801,"Morphine addiction"]
["ko05210",0.0801,"Colorectal cancer"]
["ko05211",0.0801,"Renal cell carcinoma"]
["ko03420",0.0837,"Nucleotide excision repair"]
["ko04630",0.0944,"Jak-STAT signaling pathway"]
["ko04013",0.105,"MAPK signaling pathway - fly"]
["ko05215",0.105,"Prostate cancer"]
["ko05166",0.112,"HTLV-I infection"]
["ko05220",0.116,"Chronic myeloid leukemia"]
["ko05202",0.138,"Transcriptional misregulation in cancer"]
["ko04725",0.143,"Cholinergic synapse"]
["ko05214",0.146,"Glioma"]
["ko04612",0.147,"Antigen processing and presentation"]
["ko04710",0.147,"Circadian rhythm"]
["ko04530",0.152,"Tight junction"]
["ko03018",0.158,"RNA degradation"]
["ko04068",0.158,"FoxO signaling pathway"]
["ko04062",0.176,"Chemokine signaling pathway"]
["ko04662",0.176,"B cell receptor signaling pathway"]
["ko05216",0.176,"Thyroid cancer"]
["ko03015",0.187,"mRNA surveillance pathway"]
["ko04015",0.188,"Rap1 signaling pathway"]
["ko04150",0.203,"mTOR signaling pathway"]
["ko04650",0.203,"Natural killer cell mediated cytotoxicity"]
["ko04660",0.203,"T cell receptor signaling pathway"]
["ko04911",0.203,"Insulin secretion"]
["ko04916",0.203,"Melanogenesis"]
["ko05033",0.203,"Nicotine addiction"]
["ko05144",0.203,"Malaria"]
["ko00310",0.21,"Lysine degradation"]
["ko04914",0.21,"Progesterone-mediated oocyte maturation"]
["ko05010",0.21,"Alzheimer's disease"]
["ko04070",0.238,"Phosphatidylinositol signaling system"]
["ko04140",0.238,"Regulation of autophagy"]
["ko04620",0.238,"Toll-like receptor signaling pathway"]
["ko04640",0.238,"Hematopoietic cell lineage"]
["ko04912",0.238,"GnRH signaling pathway"]
["ko04970",0.238,"Salivary secretion"]
["ko05152",0.238,"Tuberculosis"]
["ko05160",0.238,"Hepatitis C"]
["ko05221",0.238,"Acute myeloid leukemia"]

{"sheet":"MetaHIT - elevated in CD","index":2,"n_rows":40,"n_cols":3,"rows_kept":40,"cut":false,"hidden":false,"merged":[]}
["Module","q value","Description"]
["M00122",5.53E-006,"Cobalamin biosynthesis, cobinamide => cobalamin"]
["M00008",0.00352,"Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate"]
["M00078",0.00352,"Heparan sulfate degradation"]
["M00511",0.00352,"PleC-PleD (cell fate control) two-component regulatory system"]
["M00004",0.0125,"Pentose phosphate pathway (Pentose phosphate cycle)"]
["M00061",0.0148,"Uronic acid metabolism"]
["M00572",0.0242,"Pimeloyl-ACP biosynthesis, BioC-BioH pathway, malonyl-ACP => pimeloyl-ACP"]
["M00124",0.0458,"Pyridoxal biosynthesis, erythrose-4P => pyridoxal-5P"]
["M00176",0.0458,"Assimilatory sulfate reduction, sulfate => H2S"]
["M00577",0.0458,"Biotin biosynthesis, BioW pathway, pimelate => pimeloyl-CoA => biotin"]
["M00114",0.057,"Ascorbate biosynthesis, plants, glucose-6P => ascorbate"]
["M00362",0.057,"Nucleotide sugar biosynthesis, prokaryotes"]
["M00373",0.105,"Ethylmalonyl pathway"]
["M00616",0.127,"Sulfate-sulfur assimilation"]
["M00144",0.154,"NADH:quinone oxidoreductase, prokaryotes"]
["M00361",0.175,"Nucleotide sugar biosynthesis, eukaryotes"]
["M00613",0.175,"Anoxygenic photosynthesis in green nonsulfur bacteria"]
["M00376",0.191,"3-Hydroxypropionate bi-cycle"]
[]
["Pathway","q value","Description"]
["ko01100",1.19E-011,"Metabolic pathways"]
["ko00520",1.98E-006,"Amino sugar and nucleotide sugar metabolism"]
["ko01110",0.000212,"Biosynthesis of secondary metabolites"]
["ko00040",0.000313,"Pentose and glucuronate interconversions"]
["ko00531",0.000313,"Glycosaminoglycan degradation"]
["ko00051",0.000506,"Fructose and mannose metabolism"]
["ko02020",0.000527,"Two-component system"]
["ko00511",0.0011,"Other glycan degradation"]
["ko00780",0.00244,"Biotin metabolism"]
["ko00620",0.0289,"Pyruvate metabolism"]
["ko00860",0.0328,"Porphyrin and chlorophyll metabolism"]
["ko00030",0.047,"Pentose phosphate pathway"]
["ko00630",0.0601,"Glyoxylate and dicarboxylate metabolism"]
["ko01200",0.0887,"Carbon metabolism"]
["ko00311",0.095,"Penicillin and cephalosporin biosynthesis"]
["ko00340",0.113,"Histidine metabolism"]
["ko01120",0.115,"Microbial metabolism in diverse environments"]
["ko00480",0.122,"Glutathione metabolism"]
["ko00790",0.122,"Folate biosynthesis"]