Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10

Supplemental material

• Supplemental file 1 -

  Fig. S1 (Analysis of residues of the apex region of CDR-H3.)

  Fig. S2 (Secondary structure.)

  Fig. S3 (Temperature dependence of binding of peptide to Fabs determined by SPR.)

  Fig. S4 (Crystallographic B factors of Fab in the bound and unbound state.)

  Table S1 (Hydrogen bonds between 4E10 and 4E10ep.)

  Tables S2 (Interaction surface between the light chain of 4E10 Fabs and of 4E10ep.)

  Table S3 (Interaction surface between the heavy chain of 4E10 Fabs and of 4E10ep.)

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