{"text_format":"2","workbook":"xlsx","n_sheets":4,"sheets":["Andersen","Epstein","Fredriksson","HGMD"],"not_rendered":{"charts":0,"images":1,"macros":0,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1904"}

{"sheet":"Andersen","index":0,"n_rows":22,"n_cols":11,"rows_kept":22,"cut":false,"hidden":false,"merged":[]}
[]
[null,"Name","Gene","TF or motif","Reference PubMed ID","dbSNP ID","HGMD ID","Nucleotide change","TF-binding site affected","Location","Disease / function"]
[null,"AGTRL1_SP1|GAIN","APLNR","Sp1",17309882,"rs9943582","CR072301","T -> C","Gain","Promoter","Brain infarction"]
[null,"ITGA2_SP1|LOSS","ITGA2","Sp1",11313353,"rs28095 ","CR015117","C -> T","Loss","Promoter","Reduced transcription"]
[null,"NFKBIL1_USF1|LOSS","NFKBIL1","USF1",15473256,"rs2071592","CR031477","A -> T","Loss","Promoter","Rheumatoid arthritis"]
[null,"IRF2_IRF1|LOSS","IRF2","IRF1*",9054665,null,null,"A -> C","Loss","Exon","Induced expression"]
[null,"AFP_HNF-1_1|GAIN","AFP","HNF-1",14699509,null,"CR042571","C -> A","Gain","Promoter","Hereditary persistence of alpha-fetoprotein"]
[null,"AFP_HNF-1_2|GAIN","AFP","HNF-1",7684942,null,"CR930871","G -> A","Gain","Promoter","Hereditary persistence of alpha-fetoprotein"]
[null,"SP1_NFY|UNKNOWN","SP1","NF-Y",12513689,null,null,"T -> G","Unknown","Promoter","Expression regulation"]
[null,"ALOX15_SPI1|GAIN","ALOX15","SPI1",16320347,"rs11568070","CR061329","C -> T","Gain","Promoter","Altered transcriptional activity"]
[null,"CETP_SP1|UNKNOWN","CETP","Sp1",10669650,"rs1800775","CR000229","C -> A","Unknown","Upstream","Higher HDL cholesterol level"]
[null,"SFTPB_SP-1|GAIN","SFTPB","Sp1*",17071721,"rs2077079","CR077669","T -> C","Gain","Exon","Increased promoter activity"]
[null,"PTGS2_c-MYB|GAIN","PTGS2","c-MYB",16083713,"rs689466","CR053506","T -> C","Gain","Upstream","Oesophageal cancer"]
[null,"LIPC_USF|LOSS","LIPC","USF",11257263,"rs1800588","CR971949","C -> T","Loss","Promoter","Lower hepatic lipase activity"]
[null,"FTH1_NFY|UNKNOWN","FTH1","NF-Y",16797877,"rs114778979 ","CR063405","C -> A","Unknown","Promoter","Reduced expression"]
[null,"HOXB7_USF1|UNKNOWN","HOXB7","USF-1*",12697323,null,null,"C -> G","Unknown","Promoter","Reduced expression"]
[null,"FLT1_P53|GAIN","FLT1","p53",17242190,"rs111458691","CR068643","G -> A","Gain","Upstream","Altered response to p53"]
[null,"GPD2_NRF2|UNKNOWN","GPD2","NRF-2",10954707,null,null,"G -> T","Unknown","Intron","Reduced promoter activity"]
[null,"F9_HLF|UNKNOWN","F9","HLF",10073576,null,null,"G -> T","Unknown","Promoter","Enhanced binding"]
[null,"OPRM1_NFKB|UNKNOWN","OPRM1","NFkB",16843022,null,"CR077384","G -> A","Unknown","Upstream","Reduced promoter activity"]
[null,"FECH_SP1|LOSS","FECH","SP1",15850836,null,null,"C -> G","Loss","Promoter","Erythropoietic protoporphyria"]
[null,"TCOf1_YY1|LOSS","TCOF1","YY1",16102917,"rs28372960","CR054286","C -> T","Loss","Promoter","Altered gene expression"]

{"sheet":"Epstein","index":1,"n_rows":15,"n_cols":10,"rows_kept":15,"cut":false,"hidden":false,"merged":[]}
["Name","Gene","TF or motif","Reference PubMed ID","dbSNP ID","HGMD ID","Nucleotide change","TF-binding site affected","Location","Disease / function"]
["IRF6_AP-2alpha|LOSS","IRF6","AP-2alpha",18836445,"rs642961","CR084879","A -> G","Loss","Upstream","Nonsyndromic cleft lip"]
["HBB_CCAAT|UNKNOWN","HBB","CCAAT",21801233,"rs281864518","CR118399","G -> A","Unknown","Promoter","Thalassaemia beta"]
["HBB_CACCC_1|UNKNOWN","HBB","CACCC",2713503,"rs63751208","CR890140","G -> A","Unknown","Promoter","Thalassaemia beta, silent"]
["COL1A1_Sp1|UNKNOWN","COL1A1","Sp1",8841196,"rs1800012","CR961723","C -> A","Unknown","Intron","Osteoporosis"]
["SOX9_MSX1|UNKNOWN","SOX9","MSX1",19234473,"rs78542003","CR091256","T -> C","Unknown","Upstream","Pierre Robin sequence"]
["GP1BB_GATA-1|LOSS","GP1BB","GATA-1",8703016,null,"CR961733","C -> G","Loss","Promoter","Bernard-Soulier syndrome"]
["PKLR_GATA-A|LOSS","PKLR","GATA-1",11054094,null,"HR971465","T -> C","Loss","Promoter","Pyruvate kinase deficiency"]
["F9_HNF-4|UNKNOWN","F9","HNF-4",3416069,null,"CR880075","T -> A","Unknown","Promoter","Haemophilia B"]
["F9_C/EBP|LOSS","F9","C/EBP",23472758,null,"CR995250","G -> C","Loss","Promoter","Haemophilia B"]
["HBM_GATA-1|GAIN","HBM","GATA-1",16728641,null,"CR062116","T -> C","Gain","Upstream","Thalassaemia alpha"]
["HBB_CACCC_2|UNKNOWN","HBB","CACCC",1550780,"rs33994806","CR920787","G -> T","Unknown","Promoter","Thalassaemia beta"]
["HBB_CACCC_3|UNKNOWN","HBB","CACCC",1517101,"rs33994806","CR920788","G -> C","Unknown","Promoter","Thalassaemia beta"]
["HBB_CACCC_4|UNKNOWN","HBB","CACCC",1986379,"rs33944208","CR920790","G -> T","Unknown","Promoter","Thalassaemia beta"]
["HBB_CACCC_5|UNKNOWN","HBB","CACCC",6086605,"rs33944208","CR840012","G -> A","Unknown","Promoter","Thalassaemia beta"]

{"sheet":"Fredriksson","index":2,"n_rows":6,"n_cols":11,"rows_kept":6,"cut":false,"hidden":false,"merged":[]}
[]
[null,"Name","Gene","TF or motif","Reference PubMed ID","dbSNP ID","HGMD ID","Nucleotide change","TF-binding site affected","Location","Disease / function"]
[null,"TERT_ETS|GAIN_1","TERT","ETS",25383969,null,null,"G -> A","Gain","Promoter","Cancer"]
[null,"TERT_ETS|GAIN_2","TERT","ETS",25383969,null,null,"G -> A","Gain","Promoter","Cancer"]
[null,"TERT_ETS|GAIN_3","TERT","ETS",25383969,null,null,"G -> A","Gain","Promoter","Cancer"]
[null,"TERT_ETS|GAIN_4","TERT","ETS",25383969,null,null,"C -> T","Gain","Promoter","Cancer"]

{"sheet":"HGMD","index":3,"n_rows":31,"n_cols":11,"rows_kept":31,"cut":false,"hidden":false,"merged":[]}
[]
[null,"Name","Gene","TF or motif","Reference PubMed ID","dbSNP ID","HGMD ID","Nucleotide change","TF-binding site affected","Location","Disease / function"]
[null,"ADAMTS18_TEL2|GAIN","ADAMTS18","TEL2",19249006,"rs16945612","CR093412","G -> A","Gain","Promoter","Bone mass, association with"]
[null,"CDKN2B-AS1_STAT1|LOSS","CDKN2B-AS1","STAT1",21307941,"rs10811656","CR111178","C -> T","Loss","Promoter","Coronary artery disease, association with"]
[null,"CHGB_SRY|LOSS_YY1|LOSS","CHGB","SRY, YY1",20359597,"rs236141","CR102186","A -> T","Loss","Promoter","Reduced transcriptional activity"]
[null,"CHGB_c-FOS|LOSS","CHGB","c-FOS",20359597,"rs236140","CR102185","A -> C","Loss","Promoter","Reduced transcriptional activity"]
[null,"CHRNA3_Oct-1|LOSS","CHRNA3","Oct-1",19491260,"rs6495309","CR093683","A -> G","Loss","Promoter","Lung cancer, increased risk, association with"]
[null,"FABP4_C/EBP|LOSS","FABP4","C/EBP",16641093,"rs77878271","CR066326","T -> C","Loss","Promoter","Hypertriglyceridaemia, reduced risk, association with"]
[null,"FAS_c-Rel|GAIN","FAS","c-Rel",18685642,"rs7901656","CR087848","T -> C","Gain","Promoter","Cystic fibrosis severity, association with"]
[null,"FMO1_YY1|LOSS","FMO1","YY1",12829732,"rs12720462","CR035992","C -> A","Loss","Promoter","Reduced promoter activity"]
[null,"FOXE1_MYF-5|LOSS","FOXE1","MYF-5",19192046,"rs111846096","CR090790","C -> G","Loss","Promoter","Cleft palate, non-syndromic"]
[null,"FOXE1_USF1|GAIN_USF2|GAIN","FOXE1","USF1, USF2",19730683,"rs1867277","CR095675","G -> A","Gain","Promoter","Thyroid cancer susceptibility, association with"]
[null,"FZD1_Egr1|GAIN","FZD1","Egr1",18715140,"rs2232158","CR093841","G -> C","Gain","Promoter","Bone mineral density, association with"]
[null,"GFI1B_Oct-1|LOSS","GFI1B","Oct-1",20143233,"rs74866944","CR103987","T -> C","Loss","Promoter","Haematological disease"]
[null,"GFI1B_GATA-1|LOSS","GFI1B","GATA-1",20143233,"rs553823091","CR103986","A -> G","Loss","Promoter","Haematological disease"]
[null,"GSTM1_AP-2-alpha|LOSS","GSTM1","AP-2-alpha",19228880,"rs412543","CR093100","C -> G","Loss","Promoter","Breast cancer, reduced risk, association with"]
[null,"HBG2_GATA-1|LOSS","HBG2","GATA-1",18443038,null,"CR083281","T -> G","Loss","Promoter","Increased promoter activity"]
[null,"IGF1_C/EBP-delta|LOSS","IGF1","C/EBP-delta",19103645,"rs35767","CR086324","C -> T","Loss","Promoter","IgF1 levels, association with"]
[null,"IL18_OCT-1|GAIN","IL18","OCT-1",19584085,"rs360719","CR095443","T -> C","Gain","Promoter","Systemic lupus erythematosus, association with"]
[null,"IL4_Oct-1|LOSS","IL4","Oct-1",19804407,"rs2070874","CR068466","C -> T","Loss","Promoter","Bronchial asthma, association with"]
[null,"LEP_Sp1|GAIN","LEP","Sp1",19408304,"rs7799039","CR024463","G -> A","Gain","Promoter","Increased transcription"]
[null,"MPZ_SOX10|LOSS","MPZ","SOX10",21179557,null,"CR108808","T -> A","Loss","Promoter","Decreased enhancer activity"]
[null,"MYC_TCF4|GAIN_beta-catenin|GAIN","MYC","TCF4, beta-catenin",20065031,"rs6983267","CR078267","T -> G","Gain","Promoter","Colorectal and prostate cancer, association with"]
[null,"PVT1_YY1|LOSS","PVT1","YY1",21814516,"rs378854","CR116476","T -> C","Loss","Promoter","Prostate cancer risk, association with"]
[null,"SIRT1_p53|LOSS","SIRT1","p53",20693263,"rs3758391","CR106742","T -> C","Loss","Promoter","Reduced nutrient-withdrawal activation"]
[null,"SLC47A1_Sp1|LOSS","SLC47A1","Sp1",17855482,"rs72466470","CR078266","G -> A","Loss","Promoter","Reduced promoter activity"]
[null,"SLC7A1_Sp1|LOSS","SLC7A1","Sp1",19067360,"rs41318021","CR071290","C -> T","Loss","Promoter","Hypertension, association with"]
[null,"SORT1_C/EBP|GAIN","SORT1","C/EBP",20686566,"rs12740374","CR105220","C -> A","Gain","Promoter","LDL-cholesterol levels, association with"]
[null,"TMPRSS2_AR|LOSS","TMPRSS2","AR",24109594,"rs8134378","CR1312801","C -> T","Loss","Promoter","Reduced androgen receptor binding"]
[null,"UGT1A7_TBP|LOSS","UGT1A7","TBP",15716465,"rs7586110","CR057794","T -> G","Loss","Promoter","Reduced promoter activity"]
[null,"UGT2B17_FOXA1|GAIN","UGT2B17","FOXA1",20628005,"rs59678213","CR109409","G -> A","Gain","Promoter","Increased expression"]