>Acinetobacter_sp. ------------------AGAGUUUGAUCAUG-GCUCAGAUUGA-ACGCUGGCGGC-A-G GC-UUAACACAUGCAAGUCGAGCGGGG-GAA----------GGUAG------CU---U-G -------CUACC-------------G-GA--CC-UAG-CGGCG-GACGGGUGAGUAAUGC UUAGGA-AU-CUGCCUAUUAG---------------------UGGGGG-ACAACAU--C- U-CGAAA-GGGAUGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UACGU-CC------------------------------------------- ------------------------------------------------------------ ----U-AC-G-------------GGA-GAAA-GCAGGGGAUC---------------U-- U-C-G--------------GACCUUGCGCUAAUAGAUGAGCCUAAG-UCGGAUUA-GCUA --GUUGGUGGGGUAAAGGCCUA-CCAAGGCGACGAUCUGU-AGCGGGUCUGAGAGGAU-G AUCCGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGGACAAUGGGC-GCA----AGCCUGAUCCAGCCAUGCCGCGU--GUGUGAAGAAGG CC--UU-AU--GGUU-GU-AAAG-CACUUUAAGCGAGGAGGAGGCUACUUUAG--AUAAU A-C-CUAGAGAUAGUGGACGUUACUCGCAG-AAUAAGCACC-GGCUA-ACU-CUGUGCCA GCAGCCGCGGUAAUACAGAGGGUGCAAGCGUUAAUCGGAUUUACUGGGCGUAAAGCGCGC GUAGGCGGCUAAU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCAAAUGUGAAAUCCCCGAGCUUAACU- --------------------------------UGGG-AA-UUGCAUUCGAUACUGGUU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AGCUA--GAGUGUGGGA G-AGGAUGGUAGAA-UUCCAGGUGUAGCGGUGAAAUGCGUAGAGAUCUGGAGGAAUACCG AUGGCGAAGGCAGCCAUCUGGCCUAACACUGACGCUGAGGUGCGAAAGCAUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCAUGCCGUAAACGAUGU-CUACUAGCCGUUGGGGC C----------------------------------------------------------- ---UUUGA---------------------------------------------------- ----------------------GGCUUUAGU-GGCGCAGCUAACGC-GAUAAGUA----- -------GACC-GCCUGGGGAGUACGG-UCGCAAGAC-UAAAACUCAAAUGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCU-GGCCUUGACAUAGUA-A--G-A-ACUU-UCCA--GAGA---UGGA-U-UGGUG- ----CC-UUCG-GG----AACUUAC-AUACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UUUCC-UUAUUUGCC-A GCGA-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-AA--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------GU---------- --C-G---------GGAACUUUAAGGAUACU-GCCA-G----UGA-CAAAC-UG-GAGGA AGGCGGGGACGACGUCAAGUCAUC-AUGGCCCUU-ACGGCCAGGGCUACACACGUGCUAC AAUG-GUCGGUACAAAGGGU---------------------------------------- ----------------------U-GCUACACAGCGAUGUGAUGCUAA-UCUC--A-AAAA GCCGAUCGUAGUCCGGAUUGGAGUCUGCAACUCGACUCCAUG-AAGUCGGAAUCGCUAGU AAUCGCGG-AUCAGA-AUGCCGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UUUGUUGC-ACCAGAAGUAGCUAGCCUAACU--------------- ----G-CA-A----------------------AGAGGGCG----------GUUACC-ACG GUGUGGCCGAUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUG- ---------------------- >Agrobacterium_tumefaciens ---------------UUGAGAGUUUGAUCCUG-GCUCAGAACGA-ACGCUGGCGGC-A-G GC-UUAACACAUGCAAGUCGAACGCCC------------------C------GC---A-A -------G-----------------------GG-GAG-UGGCA-GACGGGUGAGUAACGC GUGGGA-AU-CUACCCAUCUC---------------------UGCGGA-AUAGCUC--U- G-GGAAA-CUGGAAUUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UACGC-CC------------------------------------------- ------------------------------------------------------------ ----U-AC-G-------------GGG-GAAA-GA-----------------------U-- U-U-A--------------------UCGGGGAUGGAUGAGCCCGCG-UUGGAUUA-GCUA --GUUGGUGGGGUAAAGGCCUA-CCAAGGCGACGAUCCAU-AGCUGGUCUGAGAGGAU-G AUCAGCCACAUUGGGACUGAGACACGGCCCAAACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGGACAAUGGGC-GCA----AGCCUGAUCCAGCCAUGCCGCGU--GAGUGAUGAAGG CC--UU-AG--GGUU-GU-AAAG-CUCUUUCACCGAUGAAGA-------------UA--- A--------------UGACGGUAGUCGGAG-AAGAAGCCCC-GGCUA-ACU-UCGUGCCA GCAGCCGCGGUAAUACGAAGGGGGCUAGCGUUGUUCGGAAUUACUGGGCGUAAAGCGCAC GUAGGCGGAUAUU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCAGGGGUGAAAUCCCGCAGCUCAACU- --------------------------------GCGG-AA-CUGCCUUUGAUACUGGGU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AUCUU--GAGUAUGGAA G-AGGUAAGUGGAA-UUCCGAGUGUAGAGGUGAAAUUCGUAGAUAUUCGGAGGAACACCA GUGGCGAAGGCGGCUUACUGGUCCAUUACUGACGCUGAGGUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGA-AUGUUAGCCGUCGGGCA G----------------------------------------------------------- ----UAUA---------------------------------------------------- ----------------------CUGUUCGGU-GGCGCAGCUAACGC-AUUAAACA----- -------UUCC-GCCUGGGGAGUACGG-UCGCAAGAU-UAAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGCAGAA-CCUU- A-CCA-GCUCUUGACAUUCGGGG--U-A-UGGGCAUUG--GAGA---CGAUGU-CCUUC- ----AG-UUAGGCU----GGCCCCA-GAACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-CGCCC-UUAGUUGCC-A GCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-UA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUAAGGGGACU-GCCG-G----UGA-UAAGC-CGAGAGGA AGGUGGGGAUGACGUCAAGUCCUC-AUGGCCCUU-ACGGGCUGGGCUACACACGUGCUAC AAUG-GUGGUGACAGUGGGC---------------------------------------- ----------------------A-GCGAGACAGCGAUGUCGAGCUAA-UCUC--C--AAA AGCCAUCUCAGUUCGGAUUGCACUCUGCAACUCGAGUGCAUG-AAGUUGGAAUCGCUAGU AAUCGCAG-AUCAGC-AUGCUGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UUGGUUUU-ACCCGAAGGUAGUGCGCUAACC--------------- ----G-CA-A----------------------GGAGGCAG----------CUAACC-ACG GUAGGGUCAGCGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCUU----------- >Anabaena_variabilis ------------AAACGGAGAGUUUGAUCCUG-GCUCAGGAUGA-ACGCUGGCGGU-A-U GC-UUAACACAUGCAAGUCGAACGGAA-----------------UC------UU---C-G -------GA----------------------UU-UAG-UGGCG-GACGGGUGAGUAACGC GUGAGA-AU-CUAGCUCUAGG---------------------UCGGGG-ACAACCA--C- U-GGAAA-CGGUGGCUAAUACCGGA----------------------------------- ------------------------------------------------------------ ---------UGU-G-CC------------------------------------------- ------------------------------------------------------------ ----G-AA-A-------------GGU-GAAA-GA-----------------------U-- U-U-A--------------------UUGCCUAGAGAUGAGCUCGCG-UCUGAUUA-GCUA --GUUGGUGUGGUAAGAGCGCA-CCAAGGCGACGAUCAGU-AGCUGGUCUGAGAGGAU-G AUCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UUUUCCGCAAUGGGC-GAA----AGCCUGACGGAGCAAUACCGCGU--GAGGGAGGAAGG CU--CU-UG--GGUU-GU-AAAC-CUCUUUUCUCAGGGAAUA-------------AGAAA G--------------UGAAGGUACCUGAGG-AAUAAGCAUC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGAUGCAAGCGUUAUCCGGAAUGAUUGGGCGUAAAGCGUCC GCAGGUGGCACUG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUGCUGUUAAAGAGCAAGGCUCAACC- --------------------------------UUGU-AA-AGGCAGUGGAAACUACAG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AGCUA--GAGUACGUUC G-GGGCAGAGGGAA-UUCCUGGUGUAGCGGUGAAAUGCGUAGAGAUCAGGAAGAACACCG GUGGCGAAAGCGCUCUGCUAGGCCGUAACUGACACUGAGGGACGAAAGCUAGGGGAGCGA AUGGGAUUAGAUACCCCA-GUAGUCCUAGCCGUAAACGAUGG-AUACUAGGCGUGGCUUG U----------------------------------------------------------- ---AUCGA---------------------------------------------------- ---------------------CCCGAGCCGU-GCCGGAGCCAACGC-GUUAAGUA----- -------UCCC-GCCUGGGGAGUACGC-ACGCAAGUG-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGUAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCA-AGACUUGACAUGUCG-C--G-A-AUCU-UCUU--GAAA---GGGA-A-GAGUG- ----CC-UUAG-GG----AGCGCGA-ACACAGG-UGGUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-CGUUU-UUAGUUGCC-A GCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-AA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUAGAGAGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCAGC-AUGCCCCUU-ACGUCUUGGGCUACACACGUACUAC AAUG-CUACGGACAGAGGGC---------------------------------------- ----------------------A-GCAAGCUAGCGAUAGCAAGCAAA-UCCC--G-UAAA CCGUAGCUCAGUUCAGAUCGCAGGCUGCAACUCGCCUGCGUG-AAGGAGGAAUCGCUAGU AAUUGCAG-GUCAGC-AUACUGCAGUGAAUUCGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGAAG-CUGGCAAC-GCCCGAAGUCAUUACUCCAACCA-------------- ----U-UC-G---------------------UGGGGGAGG----------AUGCCU-AAG GCAGUGCUGGUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGUGGCUGG AUCACCUCCUUU---------- >Azoarcus_sp. ------------AACUUAAGAGUUUGAUCCUG-GCUCAGAUUGA-ACGCUGGCGGC-A-U GC-UUUACACAUGCAAGUCGAACGGCAGCGG-----------GGGC------UU---C-G -------GCCC-----------G--C-CG--GC-GAG-UGGCG-AACGGGUGAGUAAUGC AUCGGA-AC-GUGCCCAGUCA---------------------UGGGGG-AUAACUA--C- G-CGAAA-GCGUAGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UACGC-CC------------------------------------------- ------------------------------------------------------------ ----U-GA-G-------------GGG-GAAA-GUGGGGGAUC---------------G-- C-A-A--------------GACCUCACGUGAUUGGAGCGGCCGAUG-UCAGAUUA-GCUA --GUUGGUGAGGUAAAGGCUCA-CCAAGGCGACGAUCUGU-AGCGGGUCUGAGAGGAU-G AUCCGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UUUUGGACAAUGGGC-GAA----AGCCUGAUCCAGCCAUGCCGCGU--GAGUGAAGAAGG CC--UU-CG--GGUU-GU-AAAG-CUCUUUCGGACGGAAAGAAAUCGCGCGGG--CUAAU A-U-CCCGCG-UGGAUGACGGUACCGUAAG-AAGAAGCACC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGGUGCGAGCGUUAAUCGGAAUUACUGGGCGUAAAGCGUGC GCAGGCGGUUUUG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGACAGGUGUGAAAUCCCCGGGCUUAACC- --------------------------------UGGG-AA-CUGCGCUUGUGACUGCAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GAGUACGGCA G-AGGGGGGUGGAA-UUCCACGUGUAGCAGUGAAAUGCGUAGAGAUGUGGAGGAACACCG AUGGCGAAGGCAGCCCCCUGGGCCUGUACUGACGCUCAUGCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCCUAAACGAUGU-CAACUAGUUGUUCGUAG A----------------------------------------------------------- ---GGUAA---------------------------------------------------- ---------------------CUCUGUGAGU-AACGCAGCUAACGC-GUGAAGUU----- -------GACC-GCCUGGGGAGUACGG-CCGCAAGGU-UAAAACUCAAAGGAAUUGACGG GGACCCGC-ACAA-GCGGUGGAUGAUGUGGAUUAAUUCGAUGCAACGCGAAAAA-CCUU- A-CCU-ACCCUUGACAUGCCU-G--G-A-ACCU-UGGU--GAGA---GCCG-A-GGGUG- ----CC-UUCG-GG----AACCAGG-ACACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UGUCA-UUAAUUGCC-A UCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-CA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUUUAAUGAGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCCUC-AUGGCCCUU-AUGGGUAGGGCUUCACACGUCAUAC AAUG-GUCGGUACAGAGGGU---------------------------------------- ----------------------U-GCCAAACCGCGAGGUGGAGCUAA-UCCC--U-UAAA GCCGAUCGUAGUCCGGAUCGUAGUCUGCAACUCGACUGCGUG-AAGUCGGAAUCGCUAGU AAUCGCAG-AUCAGC-AUGCUGCGGUGAAUACGUUCCCGGGUCUUGUACACACCGCCCGU CACACCAUGGGAG-UGGGUUUC-ACCAGAAGUAGGUAGCUUAACC--------------- ----U-UC-G----------------------GGAGGGCG----------CUUACC-ACG GUGAGAUUCAUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAUCGGAAGGUGCGGCUGG AUCACCUCCUU----------- >Bacillus_anthracis ------------UUUGGAGAAGUUUGAUCCUG-GCUCAGGAUGA-ACGCUGGCGGC-G-U GC-CUAAUACAUGCAAGUCGAGCGAAU-GGA--------UUAAGAG------CU---U-G -------CUCUUAU-----------G-AA--GU-UAG-CGGCG-GACGGGUGAGUAACAC GUGGGUAAC-CUGCCCAUAAG---------------------ACUGGG-AUAACUC--C- G-GGAAA-CCGGGGCUAAUACCGGA----------------------------------- ------------------------------------------------------------ ---------UAACA-UUUUGAA-CC----------------------------------- ------------------------------------------------------------ ----G-CA-U---GGU-UC-GAAAUU-GAAA-GGCGGC-------------------U-- U-C-G----------------GCUGUCACUUAUGGAUGGACCCGCG-UCGCAUUA-GCUA --GUUGGUGAGGUAACGGCUCA-CCAAGGCAACGAUGCGU-AGCCGACCUGAGAGGGU-G AUCGGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUAGGGAA UCUUCCGCAAUGGAC-GAA----AGUCUGACGGAGCAACGCCGCGU--GAGUGAUGAAGG CU--UU-CG--GGUC-GU-AAAA-CUCUGUUGUUAGGGAAGAACAAGUGCUAGU-UGAAU A-A-GCUGGC-ACCUUGACGGUACCUAACC-AGAAAGCCAC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGUGGCAAGCGUUAUCCGGAAUUAUUGGGCGUAAAGCGCGC GCAGGUGGUUUCU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUGAUGUGAAAGCCCACGGCUCAACC- --------------------------------GUGG-AG-GGUCAUUGGAAACUGGGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUU--GAGUGCAGAA G-AGGAAAGUGGAA-UUCCAUGUGUAGCGGUGAAAUGCGUAGAGAUAUGGAGGAACACCA GUGGCGAAGGCGACUUUCUGGUCUGUAACUGACACUGAGGCGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGA-GUGCUAAGUGUUAGAGG G----------------------------------------------------------- ---UUUCC---------------------------------------------------- ---------------------GCCCUUUAGU-GCUGAAGUUAACGC-AUUAAGCA----- -------CUCC-GCCUGGGGAGUACGG-CCGCAAGGC-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGAAGAA-CCUU- A-CCA-GGUCUUGACAUCCUC-U--G-A-CAAC-CCUA--GAGA---UAGG-G-CUUCU- ----CC-UUCG-GG----AGCAGAG-UGACAGG-UGGUGCAUGGUUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UGAUC-UUAGUUACC-A UCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-AA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUAAGGUGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAAUCAUC-AUGCCCCUU-AUGACCUGGGCUACACACGUGCUAC AAUG-GACGGUACAAAGAGC---------------------------------------- ----------------------U-GCAAGACCGCGAGGUGGAGCUAA-UCUC--A-UAAA ACCGUUCUCAGUUCGGAUUGUAGGCUGCAACUCGCCUACAUG-AAGCUGGAAUCGCUAGU AAUCGCGG-AUCAGC-AUGCCGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCACGAGAG-UUUGUAAC-ACCCGAAGUCGGUGGGGUAACCU-------------- ----U-UU-U----------------------GGAGCCAG----------CCGCCU-AAG GUGGGACAGAUGAUUGGGGUGAAGUCGUAACAAGGUAGCCGUAUCGGAAGGUGCGGCUGG AUCACCU--------------- >Bacteroides_thetaiotaomicron ------CUUUUACAAUGAAGAGUUUGAUCCUG-GCUCAGGAUGA-ACGCUAGCUAC-A-G GC-UUAACACAUGCAAGUCGAGGGGCAGCAU------UUCAGUUUG------CU---U-G -------CAAACUGGA------G--A-UG--GC-GAC-CGGCG-CACGGGUGAGUAACAC GUAUCCAAC-CUGCCGAUAAC---------------------UCGGGG-AUAGCCU--U- U-CGAAA-GAAAGAUUAAUACCCGA----------------------------------- ------------------------------------------------------------ ---------UGGUAUAAUCAGA-CC----------------------------------- ------------------------------------------------------------ ----G-CA-U---GGU-CU-UGUUAU-UAAA-GA-----------------------A-- U-U----------------------UCGGUUAUCGAUGGGGAUGCG-UUCCAUUA-GGCA --GUUGGUGAGGUAACGGCUCA-CCAAACCUUCGAUGGAU-AGGGGUUCUGAGAGGAA-G GUCCCCCACAUUGGAACUGAGACACGGUCCAAACUCCUACGG-GAGGCAGCAGUGAGGAA UAUUGGUCAAUGGGC-GCA----GGCCUGAACCAGCCAAGUAGCGU--GAAGGAUGACUG CCC-UA-UG--GGUU-GU-AAAC-UUCUUUUAUAUGGGAAUAAAGUUUUCCA---CG--U G-----UGGA-AUUUUGUAUGUACCAUAUG-AAUAAGGAUC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGAUCCGAGCGUUAUCCGGAUUUAUUGGGUUUAAAGGGAGC GUAGGUGGACAGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCAGUUGUGAAAGUUUGCGGCUCAACC- --------------------------------GUAA-AA-UUGCAGUUGAUACUGGCU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GUCUU--GAGUACAGUA G-AGGUGGGCGGAA-UUCGUGGUGUAGCGGUGAAAUGCUUAGAUAUCACGAAGAACUCCG AUUGCGAAGGCAGCUCACUGGACUGCAACUGACACUGAUGCUCGAAAGUGUGGGUAUCAA ACAGGAUUAGAUACCCUG-GUAGUCCACACAGUAAACGAUGA-AUACUCGCUGUUUGCGA ------------------------------------------------------------ ----UAUA---------------------------------------------------- -----------------------CAGUAAGC-GGCCAAGCGAAAGC-AUUAAGUA----- -------UUCC-ACCUGGGGAGUACGC-CGGCAACGGGUGAAACUCAAAGGAAUUGACGG GGGCCCGU-ACAA-GCGGAGGAACAUGUGGUUUAAUUCGAUGAUACGCGAGGAA-CCUU- A-CCC-GGGCUUAAAUUGCAUUU--G-A-AUAU-AUUG--GAAA---CAGU-A-UAG--- ----CC-GUAA-GG------CAAAU-GUGAAGG-UGCUGCAUGGUUGUCGUCAGCUCGUG CC-GUGAGGUGUCGGCUUAAGUGCCAUAACGAGCGCAACCCU-UAUCU-UUAGUUACU-A ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-CA--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------GC---------- --U-G---------AGGACUCUAGAGAGACU-GCCG-U----CG--UAAGA-UGUGAGGA AGGUGGGGAUGACGUCAAAUCAGC-ACGGCCCUU-ACGUCCGGGGCUACACACGUGUUAC AAUG-GGGGGUACAGAAGGC---------------------------------------- ----------------------A-GCUACCUGGUGACAGGAUGCUAA-UCCC--A--AAA GCCUCUCUCAGUUCGGAUCGAAGUCUGCAACCCGACUUCGUC-AAGCUGGAUUCGCUAGU AAUCGCGC-AUCAGCCAUGGCGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CAAGCCAUGAAAG-CCGGGGGU-ACCUGAAGUACGUAACC-------------------- ----G-CA-A--------------------------GGAG----------CGUCCU-AGG GUAAAACUGGUAAUUGGGGCUAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGCGGCUGG AACACCUCCU------------ >Bartonella_henselae ---------UUCAAUAUGAGAGUUUGAUCCUG-GCUCAGAACGA-ACGCUGGCGGC-A-G GC-UUAACACAUGCAAGUCGAGCGCAC----------------UCU------UU---U-- -------AGA---------------------GU-GAG-CGGCA-AACGGGUGAGUAACGC GUGGGA-AU-CUACCCAUCUC---------------------UACGGA-AUAACAC--A- G-AGAAA-UUUGUGCUAAUACCGUA----------------------------------- ------------------------------------------------------------ ---------UACGU-CC------------------------------------------- ------------------------------------------------------------ ----U-UA-G-------------GGA-GAAA-GA-----------------------U-- U-U-A--------------------UCGGAGAUGGAUGAGCCCGCG-UUGGAUUA-GCUA --GUUGGUGAGGUAACGGCUCA-CCAAGGCGACGAUCCAU-AGCUGGUCUGAGAGGAU-G AUCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGGACAAUGGGG-GCA----ACCCUGAUCCAGCCAUGCCGCGU--GAGUGAUGAAGG CC--CU-AG--GGUU-GU-AAAG-CUCUUUCACCGGUGAAGA-------------UA--- A--------------UGACGGUAACCGGAG-AAGAAGCCCC-GGCUA-ACU-UCGUGCCA GCAGCCGCGGUAAUACGAAGGGGGCUAGCGUUGUUCGGAUUUACUGGGCGUAAAGCGCAU GUAGGCGGAUAUU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCAGAGGUGAAAUCCCAGGGCUCAACC- --------------------------------CUGG-AA-CUGCCUUUGAUACUGGGU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AUCUU--GAGUGUGGAA G-AGGUGAGUGGAA-UUCCGAGUGUAGAGGUAAAAUUCGUAGAUAUUCGGAGGAACACCA GUGGCGAAGGCGGCUCACUGGUCCAUUACUGACGCUGAGGUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGA-AUGUUAGCCGUCGGGCG G----------------------------------------------------------- ----UUUA---------------------------------------------------- ----------------------CUGCUCGGU-GGCGCAGCUAACGC-GUUAAACA----- -------UUCC-GCCUGGGGAGUACGG-UCGCAAGAU-UAAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGCAGAA-CCUU- A-CCA-GCCCUUGACAUCCCG-A--UCG-CGGAAGGUG--GAGA---CACCCU-CCUUC- ----AG-UUAGGCU----GGAUCGG-AGACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-CGCCC-UUAGUUGCC-A GCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-UG--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUAGGGGGACU-GCCG-G----UGA-UAAGC-CGAGAGGA AGGUGGGGAUGACGUCAAGUCCUC-AUGGCCCUU-ACGGGCUGGGCUACACACGUGCUAC AAUG-GUGGUGACAGUGGGC---------------------------------------- ----------------------A-GCGAGACCGCGAGGUCGAGCUAA-UCUC--C--AAA AGCCAUCUCAGUUCGGAUUGCACUCUGCAACUCGAGUGCAUG-AAGUCGGAAUCGCUAGU AAUCGUGG-AUCAGC-AUGCCACGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UUGGUUUU-ACCCGAAGGUGCUGUGCUAACC--------------- ----G-CA-A----------------------GGGGGCAG----------GCAACC-ACG GUAGGGUCAGCGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGUGGCUGG AUCACCUCCUUUCU-------- >Bifidobacterium_longum -------------UGUGGAGGGUUCGAUUCUG-GCUCAGGAUGA-ACGCUGGCGGC-G-U GC-UUAACACAUGCAAGUCGAACGGGA-UCC---------AUCAGG------CU---UUG -------CUUGGU------------G-GU--GA-GAG-UGGCG-AACGGGUGAGUAAUGC GUGACCGAC-CUGCCCCAUAC---------------------ACCGGA-AUAGCUC--C- U-GGAAA-CGGGUGGUAAUGCCGGA----------------------------------- ------------------------------------------------------------ ---------UGCUCCAGUUG-A-UC----------------------------------- ------------------------------------------------------------ ----G-CA-U---GGU--C-UUCUGG-GAAA-GC-----------------------U-- U-U-C--------------------GCGGUAUGGGAUGGGGUCGCG-UCCUAUCA-GCUU --GACGGCGGGGUAACGGCCCA-CCGUGGCUUCGACGGGU-AGCCGGCCUGAGAGGGC-G ACCGGCCACAUUGGGACUGAGAUACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGCACAAUGGGC-GCA----AGCCUGAUGCAGCGACGCCGCGU--GAGGGAUGGAGG CC--UU-CG--GGUU-GU-AAAC-CUCUUUUAUCGGGGAGCAAG-C---------GA--G A-----------G--UGAGUUUACCCGUUG-AAUAAGCACC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGGUGCAAGCGUUAUCCGGAAUUAUUGGGCGUAAAGGGCUC GUAGGCGGUUCGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CGCGUCCGGUGUGAAAGUCCAUCGCUUAACG- --------------------------------GUGG-AU-CCGCGCCGGGUACGGGCG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUU--GAGUGCGGUA G-GGGAGACUGGAA-UUCCCGGUGUAACGGUGGAAUGUGUAGAUAUCGGGAAGAACACCA AUGGCGAAGGCAGGUCUCUGGGCCGUUACUGACGCUGAGGAGCGAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGGUGG-AUGCUGGAUGUGGGGCC C----------------------------------------------------------- ---GUUCCA--------------------------------------------------- ---------------------CGGGUUCCGU-GUCGGAGCUAACGC-GUUAAGCA----- -------UCCC-GCCUGGGGAGUACGG-CCGCAAGGC-UAAAACUCAAAGAAAUUGACGG GGGCCCGC-ACAA-GCGGCGGAGCAUGCGGAUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCU-GGGCUUGACAUGUUCCC--G-A-CGGU-CGUA--GAGA---UGCG-G-CUUC-- ----CC-UUCG-GG-----GCGGGU-UCACAGG-UGGUGCAUGGUCGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-CGCCC-CGUGUUGCC-A GCGG-------------------------------------------------------- ------------------------------------------------------------ ------------A---U-UA--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------GC---------- --C-G---------GGAACUCACGGGGGACC-GCCG-G----GGU-UAACU-CG-GAGGA AGGUGGGGAUGACGUCAGAUCAUC-AUGCCCCUU-ACGUCCAGGGCUUCACGCAUGCUAC AAUG-GCCGGUACAACGGGA---------------------------------------- ----------------------U-GCGACGCGGCGACGCGGAGCGGA-UCCC--U-GAAA ACCGGUCUCAGUUCGGAUCGCAGUCUGCAACUCGACUGCGUG-AAGGCGGAGUCGCUAGU AAUCGCGA-AUCAGCAACGUCGCGGUGAAUGCGUUCCCGGGCCUUGUACACACCGCCCGU CAAGUCAUGAAAG-UGGGCAGC-ACCCGAAGCCGGUGGCCUAACCC-------------- ----C-UU-GU--------------------GGGAUGGAG----------CCGUCU-AAG GUGAGGCUCGUGAUUGGGACUAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGCGGCUGG AUCACCUCCUUUCU-------- >Blochmannia_floridanus ----GGAAUUAAAAUUGAAGAGUUUGAUCAUG-GCUCAGAUUGA-ACGCUGACGGU-A-A GC-UUAACACAUGCAAGUCGAGCGGCAAACAG-----GAAAUUUAAUACC--UU---UUA -------UUUUGU------------C-UG--GC-AAG-CGGCA-AACGGGUGAGUAAAGU CUGGGG-AU-CUGCCCAAGGG---------------------AGGGGG-AUAACUA--U- U-GGAAA-CGAUAGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UGAAA-UC------------------------------------------- ------------------------------------------------------------ ----GAUG-A-------------GAU-UAAA-GUAGGGGACUUGUAUAUAAUGUU--U-- U-A---UUUAUUAUAUGUAGGCCUUAUGCCAUUGGAUGAACCCAGA-UAGGAUUA-GCUA --GUAGGUAAGGUAACGGCUUA-CCUAGGCAACGAUCCUU-AGCUGGUCUGAGAGGAC-G AUCAGCCACACUGGAACUGAGAUACGGUCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGCACAAUGGGG-GAA----ACCCUGAUGCAGCUAUACCGUGU--GUGUGAAGAAGG CC--UU-CG--GGUU-GU-AAAG-CACUUUCAAUGGGGAAGAAUUUAAGGUUG--CUAAU A-U-CAAUUU-UAAUUGACGUUACCCAUAU-AAGAAGCACC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGGUGCAAGCGUUAAUCGGAAUUACUGGGCGUAAAGAGUUC GUAGGCGGUUUAU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCAGAUGUGAAAUCCCUGAGCUUAACU- --------------------------------UAGG-AA-CUGCAUUUGAAACUGAUA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AGCUA--GAGUUUCGUA G-AGGGAGGUAGAA-UUCCAGGUGUAGCGGUGAAAUGCGUAGAGAUCUGGAGGAAUACCG GUGGCGAAGGCGGCCUCCUGGACGAAAACUGACGCUCAGGUACGAAAGCAUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCAUGCCGUAAACGAUGU-CGAUUUGAAGGUUGUGA C----------------------------------------------------------- ---CAUUG---------------------------------------------------- ---------------------AGUCGUGGCU-UUCGGAGCUAACGC-GUUAAAUC----- -------GACC-GCCUGGGGAGUACGA-CCGCAAGGU-UAAAACUCAAAUGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUAUGGUUUAAUUCGAUGCAACACGAAGAA-CCUU- A-CCU-ACUCUUGACAUCCAA-A--G-A-ACUG-UGUA--GAGA---UAUG-C-AGGUG- ----CC-UUCG-GG----AACUUUG-AGACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UU-GUGAAAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UAUCC-UUUGUUGCC-A ACGA-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-UA--A------------------------------------- ------------------------------------------------------------ ------------------------------------------------GU---------- --C-G---------GGAACUCAAAGGAGACU-GCCG-G----UGA-UAAAC-CG-GAGGA AGGUGAGGAUGACGUCAAGUCAUC-AUGGCCCUU-AUGAGUAGGGCUACAAACGUGCUAC AAUG-GCGUAUACAAAGAGA---------------------------------------- ----------------------A-GCGACCUUGCGAAAGUUAGCAAA-UCUC--A-UAAA GUACGUCUUAGUCCGGAUUGGAGUCUGCAACUCGACUCCAUG-AAGUCGGAAUCGCUAGU AAUCGUGA-AUCAGA-AUGUCACGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UGGGUUGC-AAAAGAAGUGAGUAGUUUAACCUU------------- ----G-AA-A-A-------------------AGGAGGGCG----------CUUACC-ACU UUGUGAUUCAUGACUGGGGUGAAGUCGUAACAAGGUAACCGUAGGGGAACCUGCGGUUGG AUCACCUCCUUACUUUUA---- >Bradyrhizobium_japonicum ----------CCAACUUGAGAGUUUGAUCCUG-GCUCAGAGCGA-ACGCUGGCGGC-A-G GC-UUAACACAUGCAAGUCGAGCGGGC----------------GUA------GC---A-A -------UAC---------------------GU-CAG-CGGCA-GACGGGUGAGUAACGC GUGGGA-AC-GUACCUUUUGG---------------------UUCGGA-ACAACAC--A- G-GGAAA-CUUGUGCUAAUACCGGA----------------------------------- ------------------------------------------------------------ ---------UAAGC-CC------------------------------------------- ------------------------------------------------------------ ----U-UA-C-------------GGG-GAAA-GA-----------------------U-- U-U-A--------------------UCGCCGAAAGAUCGGCCCGCG-UCUGAUUA-GCUA --GUUGGUAGGGUAACGGCCUA-CCAAGGCGACGAUCAGU-AGCUGGUCUGAGAGGAU-G AUCAGCCACAUUGGGACUGAGACACGGCCCAAACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGGACAAUGGGG-GCA----ACCCUGAUCCAGCCAUGCCGCGU--GAGUGAUGAAGG CC--CU-AG--GGUU-GU-AAAG-CUCUUUUGUGCGGGAAGA-------------UA--- A--------------UGACGGUACCGCAAG-AAUAAGCCCC-GGCUA-ACU-UCGUGCCA GCAGCCGCGGUAAUACGAAGGGGGCUAGCGUUGCUCGGAAUCACUGGGCGUAAAGGGUGC GUAGGCGGGUCUU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCAGGGGUGAAAUCCUGGAGCUCAACU- --------------------------------CCAG-AA-CUGCCUUUGAUACUGAAG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AUCUU--GAGUUCGGGA G-AGGUGAGUGGAA-CUGCGAGUGUAGAGGUGAAAUUCGUAGAUAUUCGCAAGAACACCA GUGGCGAAGGCGGCUCACUGGCCCGAUACUGACGCUGAGGCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGA-AUGCCAGCCGUUAGUGG G----------------------------------------------------------- ----UUUA---------------------------------------------------- ----------------------CUCACUAGU-GGCGCAGCUAACGC-UUUAAGCA----- -------UUCC-GCCUGGGGAGUACGG-UCGCAAGAU-UAAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGACGCAACGCGCAGAA-CCUU- A-CCA-GCCCUUGACAUGUCC-A--GGACCGGU-CGCA--GAGA---UGUG-A-CCUUC- ----UC-UUCG-GA----GCCUGGA-ACACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCC-CGUCC-UUAGUUGCU-A CCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-UA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------AGCACUCUAAGGAGACU-GCCG-G----UGA-UAAGC-CGCGAGGA AGGUGGGGAUGACGUCAAGUCCUC-AUGGCCCUU-ACGGGCUGGGCUACACACGUGCUAC AAUG-GCGGUGACAAUGGGA---------------------------------------- ----------------------U-GCUAAGGGGCGACCCUUCGCAAA-UCUC--A--AAA AGCCGUCUCAGUUCGGAUUGGGCUCUGCAACUCGAGCCCAUG-AAGUUGGAAUCGCUAGU AAUCGUGG-AUCAGC-ACGCCACGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UUGGCUUU-ACCUGAAGACGGUGCGCUAACCA-------------- ----G-CA-A---------------------UGGAGGCAG----------CCGGCC-ACG GUAGGGUCAGCGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCUUU---------- >Buchnera_aphidicola ------------------AGAGUUUGAUCAUG-GCUCAGAUUGA-ACGCUGGCGGC-A-A GC-CUAACACAUGCAAGUCGAGCGGCAGCGA-------GAAGAGAG------CU---U-G -------CUCUCUUU-------G--U-CG--GC-AAG-CGGCA-AACGGGUGAGUAAUAU CUGGGG-AU-CUACCCAAAAG---------------------AGGGGG-AUAACUA--C- U-AGAAA-UGGUAGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UAAUG-UU------------------------------------------- ------------------------------------------------------------ ----G-AA-A-------------AAC-CAAA-GUGGGGGACCU--------------U-- U---U--------------GGCCUCAUGCUUUUGGAUGAACCCAGA-CGAGAUUA-GCUU --GUUGGUAGAGUAAUAGCCUA-CCAAGGCAACGAUCUCU-AGCUGGUCUGAGAGGAU-A ACCAGCCACACUGGAACUGAGACACGGUCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGCACAAUGGGC-GAA----AGCCUGAUGCAGCUAUGCCGCGU--GUAUGAAGAAGG CC--UU-AG--GGUU-GU-AAAG-UACUUUCAGCGGGGAGGAAAAAAAUAAAA--CUAAU A-A-UUUUAU-UUCGUGACGUUACCCGCAG-AAGAAGCACC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGGUGCAAGCGUUAAUCAGAAUUACUGGGCGUAAAGAGCGC GUAGGUGGUUUUU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCAGGUGUGAAAUCCCUAGGCUCAACC- --------------------------------UAGG-AA-CUGCAUUUGAAACUGGAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AACUA--GAGUUUCGUA G-AGGGAGGUAGAA-UUCUAGGUGUAGCGGUGAAAUGCGUAGAUAUCUGGAGGAAUACCC GUGGCGAAAGCGGCCUCCUAAACGAAAACUGACACUGAGGCGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCAUGCCGUAAACGAUGU-CGACUUGGAGGUUGUUU C----------------------------------------------------------- ---CAAGA---------------------------------------------------- ----------------------GAAGUGACU-UCCGAAGCUAACGC-AUUAAGUC----- -------GACC-GCCUGGGGAGUACGG-CCGCAAGGC-UAAAACUCAAAUGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAUGCAACGCGAAAAA-CCUU- A-CCU-GGUCUUGACAUCCAC-A--G-A-AUUC-UUUA--GAAA---UAAA-G-AAGUG- ----CC-UUCG-GG----AGCUGUG-AGACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UU-GUGAAAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UAUCC-CCUGUUGCC-A GCGG-------------------------------------------------------- ------------------------------------------------------------ ------------U---U-CG--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------C---------- --C-G---------GGAACUCAGAGGAGACU-GCCG-G----UUA-UAAAC-CG-GAGGA AGGUGGGGACGACGUCAAGUCAUC-AUGGCCCUU-ACGACCAGGGCUACACACGUGCUAC AAUG-GUUUAUACAAAGAGA---------------------------------------- ----------------------A-GCAAAUCUGCAAAGACAAGCAAA-CCUC--A-UAAA GUAAAUCGUAGUCCGGACUGGAGUCUGCAACUCGACUCCACG-AAGUCGGAAUCGCUAGU AAUCGUGG-AUCAGA-AUGCCACGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UGGGUUGC-AAAAGAAGCAGGUAUCCUAACCCU------------- ----U-UA-A-A-------------------AGGAAGGCG----------CUUACC-ACU UUGUGAUUCAUGACUGGGGUGAAGUCGUAACAAGGUAACCGUAGGGGAACCUGCGGUUGG AUCACCUCCUU----------- >Burkholderia_sp. ------------------AGAGUUUGAUCCUG-GCUCAGAUUGA-ACGCUGGCGGC-A-U GC-CUUACACAUGCAAGUCGAACGGCAGCAC----------GGGUG------CU---U-G -------CACCU----------G--G-UG--GC-GAG-UGGCG-AACGGGUGAGUAAUAC AUCGGA-AC-AUGUCCUGUAG---------------------UGGGGG-AUAGCCC--G- G-CGAAA-GCCGGAUUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UACGA-UC------------------------------------------- ------------------------------------------------------------ ----U-AC-G-------------GAU-GAAA-GCGGGGGACC---------------U-- U-C-G--------------GGCCUCGCGCUAUAGGGUUGGCCGAUG-GCUGAUUA-GCUA --GUUGGUGGGGUAAAGGCCUA-CCAAGGCGACGAUCAGU-AGCUGGUCUGAGAGGAC-G ACCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UUUUGGACAAUGGGC-GAA----AGCCUGAUCCAGCAAUGCCGCGU--GUGUGAAGAAGG CC--UU-CG--GGUU-GU-AAAG-CACUUUUGUCCGGAAAGAAAUCCUUGGCU--CUAAU A-C-AGUCGG-GGGAUGACGGUACCGGAAG-AAUAAGCACC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGGUGCGAGCGUUAAUCGGAAUUACUGGGCGUAAAGCGUGC GCAGGCGGUUUGC----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGACCGAUGUGAAAUCCCCGGGCUCAACC- --------------------------------UGGG-AA-CUGCAUUGGUGACUGGCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GAGUAUGGCA G-AGGGGGGUAGAA-UUCCACGUGUAGCAGUGAAAUGCGUAGAGAUGUGGAGGAAUACCG AUGGCGAAGGCAGCCCCCUGGGCCAAUACUGACGCUCAUGCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCCUAAACGAUGU-CAACUAGUUGUUGGGGA U----------------------------------------------------------- ----UCAU---------------------------------------------------- ----------------------UUCCUUAGU-AACGUAGCUAACGC-GUGAAGUU----- -------GACC-GCCUGGGGAGUACGG-UCGCAAGAU-UAAAACUCAAAGGAAUUGACGG GGACCCGC-ACAA-GCGGUGGAUGAUGUGGAUUAAUUCGAUGCAACGCGAAAAA-CCUU- A-CCU-ACCCUUGACAUGGUC-G--G-A-AUCC-CGCU--GAGA---GGUG-G-GAGUGC ----UC-GAAA-GA---GAACCGGC-GCACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UGUCC-UUAGUUGCU-A -C---------------------------------------------------------- ------------------------------------------------------------ ----------------G-CA--A------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----G---------AGCACUCUAAGGAGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCCUC-AUGGCCCUU-AUGGGUAGGGCUUCACACGUCAUAC AAUG-GUCGGAACAGAGGGU---------------------------------------- ----------------------U-GCCAACCCGCGAGGGGGAGCUAA-UCCC--A-GAAA ACCGAUCGUAGUCCGGAUUGCACUCUGCAACUCGAGUGCAUG-AAGCUGGAAUCGCUAGU AAUCGCGG-AUCAGC-AUGCCGCGGUGAAUACGUUCCCGGGUCUUGUACACACCGCCCGU CACACCAUGGGAG-UGGGUUUU-ACCAGAAGUGGCUAGUCUAACC--------------- ----G-CA-A----------------------GGAGGACG----------GUCACC-ACG GUAGGAUUCAUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAUCGGAAGGUGCGGCUGG AUCACCUCCUUUC--------- >Caulobacter_crescentus -------------------GAGUUUGAUCCUG-GCUCAGAGCGA-ACGCUGGCGGC-A-G GC-CUAACACAUGCAAGUCGAACGGAU-----------------CC------UU---C-G -------GG----------------------AU-UAG-UGGCG-GACGGGUGAGUAACAC GUGGGA-AC-GUGCCCUUUGG---------------------UUCGGA-ACAACUC--A- G-GGAAA-CUUGAGCUAAUACCGGA----------------------------------- ------------------------------------------------------------ ---------UGUGC-CC------------------------------------------- ------------------------------------------------------------ ----U-UC-G-------------GGG-GAAA-GA-----------------------U-- U-U-A--------------------UCGCCAUUGGAGCGGCCCGCG-UCUGAUUA-GCUA --GUUGGUGAGGUAAAGGCUCA-CCAAGGCGACGAUCAGU-AGCUGGUCUGAGAGGAU-G AUCAGCCACAUUGGGACUGAGACACGGCCCAAACUCCUACGG-GAGGCAGCAGUGGGGAA UCUUGCGCAAUGGGC-GAA----AGCCUGACGCAGCCAUGCCGCGU--GAAUGAUGAAGG UC--UU-AG--GAUU-GU-AAAA-UUCUUUCACCGGGGACGA-------------UA--- A--------------UGACGGUACCCGGAG-AAGAAGCCCC-GGCUA-ACU-UCGUGCCA GCAGCCGCGGUAAUACGAAGGGGGCUAGCGUUGCUCGGAAUUACUGGGCGUAAAGGGAGC GUAGGCGGACUGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UUAGUCAGAGGUGAAAGCCCAGGGCUCAACC- --------------------------------UUGG-AA-UUGCCUUUGAUACUGGCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GUCUU--GAGUACGGAA G-AGGUAUGUGGAA-CUCCGAGUGUAGAGGUGAAAUUCGUAGAUAUUCGGAAGAACACCA GUGGCGAAGGCGACAUACUGGUCCGUUACUGACGCUGAGGCUCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGA-GUGCUAGUUGUCGGCAU G----------------------------------------------------------- ---CAUG----------------------------------------------------- ----------------------CAUGUCGGU-GACGCAGCUAACGC-AUUAAGCA----- -------CUCC-GCCUGGGGAGUACGG-UCGCAAGAU-UAAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGCAGAA-CCUU- A-CCA-CCUUUUGACAUGCCU-G--G-A-CCGC-CACA--GAGA---UGUG-G-UUUUC- ----CC-UUCG-GG----GACUGGG-ACACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-CGUGA-UUAGUUGCC-A UCAG-------------------------------------------------------- ------------------------------------------------------------ ---------------GU-UU--GG------------------------------------ ------------------------------------------------------------ -------------------------------------------------C---------- --U-G---------GGCACUCUAAUCAUACU-GCCG-G----AGU-UAAUC-CG-GAGGA AGGCGGGGAUGACGUCAAGUCCUC-AUGGCCCUU-ACAAGGUGGGCUACACACGUGCUAC AAUG-GCGACUACAGAGGGC---------------------------------------- ----------------------U-GCAAUCCCGCGAGGGGGAGCCAA-UCCC--U--AAA AGUCGUCUCAGUUCGGAUUGUUCUCUGCAACUCGAGAGCAUG-AAGUUGGAAUCGCUAGU AAUCGCGG-AUCAGC-AUGCCGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UUGGCUUU-ACCCGAAGGCGCUGCGCUAACC--------------- ----G-CA-A----------------------GGGGGCAG----------GCGACC-ACG GUAGGGUCAGCGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCC------------- >Chlamydophila_caviae ---------------CUGAGAAUUUGAUCUUG-GUUCAGAUUGA-ACGCUGGCGGC-G-U GG-AUGAGGCAUGCAAGUCGAACGGAA-UAA-----------UAGC------UU---C-G -------GUUA--------------U-UA--UU-UAG-UGGCG-GAAGGGUUAGUAAUAC AUAGAUAAU-CUGUCCUCAAC---------------------UUGGGA-AUAACGG--U- U-GGAAA-CGACCGCUAAUACCGAA----------------------------------- ------------------------------------------------------------ ---------UGUGGUAUGUU-U-AG----------------------------------- ------------------------------------------------------------ ----G-CA-U---CUA-AA-ACAUAU-UAAA-GAAGGGGAUC---------------U-- U-C-G--------------GACCUUUCGGUUAAGGAAGAGUCUAUG-GGAUAUCA-GCUU --GUUGGUGGGGUAAUGGCCUA-CCAAGGCUUUGACGUCU-AGGCGGAUUGAGAGAUU-G ACCGCCAACACUGGGACUGAGACACUGCCCAGACUUCUACGG-AAGGCUGCAGUCGAGAA UCUUUCGCAAUGGAC-GAA----AGUCUGACGAAGCGACGCCGCGU--GUGUGAUGAAGG CU--CU-AG--GGUU-GU-AAAG-CACUUUCGCUUGGGAAUAAGAGAAGUUGG--CUAAU A-U-CCAACU-GAUUUGAGCGUACCAGGUA-AAGAAGCACC-GGCUA-ACU-CCGUGCCA GCAGCUGCGGUAAUACGGAGGGUGCUAGCGUUAAUCGGAUUUAUUGGGCGUAAAGGGCGU GUAGGCGGAAAGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------AAAGUUAGAUGUUAAAUCUUGGGGCUCAACC- --------------------------------CCAA-GC-CAGCAUCUAAUACUAUCU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------UUCUA--GAGGGUAGAU G-GAGAAAAGGGAA-UUCCACGUGUAGCGGUGAAAUGCGUAGAUAUGUGGAAGAACACCA GUGGCGAAGGCGCUUUUCUAAUUUACACCUGACGCUAAGGCGCGAAAGCAAGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCUUGCCGUAAACGAUGC-AUACUUGAUGUGGAUAG U----------------------------------------------------------- ---CUCAAC--------------------------------------------------- ----------------------CCUAUCCGU-GUCGUAGCUAACGC-GUUAAGUA----- -------UGCC-GCCUGAGGAGUACAC-UCGCAAGGG-UGAAACUCAAAAGAAUUGACGG GGGCCCGC-ACAA-GCAGUGGAGCAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCU-GGGCUUGACAUGUAUUU--G-A-CCGC-GGCA--GAAA---UGUC-G-UUUU-- ----CC-GCAA-GG-----ACAGAU-ACACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG CC-GUGAGGUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UAUCG-UUAGUUGCC-A ACAC-------------------------------------------------------- ------------------------------------------------------------ ------------U---U-AG--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------G---------- --U-G---------GGAACUCUAACGAGACU-GCCU-G----GGU-UAACC-AG-GAGGA AGGCGAGGAUGACGUCAAGUCAGC-AUGGCCCUU-AUGCCCAGGGCCACACACGUGCUAC AAUG-GCCAGUACAGAAGGU---------------------------------------- ----------------------A-GCAAUAUCGCAAGAUGGAGCAAA-UCCU--C--AAA GCUGGCCCCAGUUCGGAUUGUAGUCUGCAACUCGACUACAUG-AAGUCGGAAUUGCUAGU AAUGGCGU-GUCAGCUAUAACGCCGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACAUCAUGGGAG-UUGGUUUU-GCCUUAAGUCGUUGACUCAACCU-------------- ----G-CA-A---------------------AGGAGAGAG----------GCGCCC-AAG GUGAGGCUGAUGACUGGGAUGAAGUCGUAACAAGGUAGCCCUACCGGAAGGUGGGGCUGG AUCACCUCCUUU---------- >Chlorobium_tepidum -----------ACAACGGAGAGUUUGAUCCUG-GCUCAGGACGA-ACGCUGGCGGC-G-U GC-CUAACACAUGCAAGUCAAAGUUUGAGUA-------------AC------UU---C-G -------GU----------------U-AC-AAA-GACUUGGCG-CAAGGGUGAGUAAGGC AUAGGUAAU-CUGCCUUUUGG---------------------UCUGGG-AUAACCC--C- G-AGAAA-UCGGGAACAAUACCAGA----------------------------------- ------------------------------------------------------------ ---------UGAUGCAGCGGAA-UC----------------------------------- ------------------------------------------------------------ ----G-CA-U---GGU-UA-UGUUGU-UAAA-GA-----------------------U-- U-U-A--------------------UCGCCAAAAGAUGAGCCUAUG-UUCCAUCA-GGUA --GUUGGUAGGGUAACGGCCUA-CCAAGCCUACGACGGAU-AGCUGGUCUGAGAGGAU-G AUCAGCCACAUUGGAACUGAGACACGGUCCAGACUCCUACGG-GAGGCAGCAGUGAGGAA UAUUGCGCAAUGGGC-GAA----AGCCUGACGCAGCAACGCCGCGU--GGAUGAUGAAGU UC--UU-CG--GAAU-GU-AAAA-UCCUUUUGCAGGAGACGAAGAGGUCGG----CU--U G------CCG-GCUGUGACGGUACCCUGCG-AAUAAGCCAC-GGCUA-ACU-CUGUGCCA GCAGCCGCGGUGAUACAGGGGUGGCAAGCGUUGUCCGGAUUUACUGGGUGUAAAGGGUGC GCAGGCGGAUCGA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCGGGGGUUAAAUCCAUGUGCUUAACA- --------------------------------CAUG-CA-CGGCUUCCGAUACUGUUG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AUCUA--GAGUCUCGAA G-AGGAAGGUGGAA-UUUCCGGUGUAACGGUGGAAUGUGUAGAUAUCGGAAAGAACACCA GUGGCGAAGGCAGCCUUCUGGUCGAGUACUGACGCUCAGGCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGA-AUACUAGAUGUUGGUCA ------------------------------------------------------------ ----UAG----------------------------------------------------- -----------------------UGAUCAGU-GUCGCAGCUAACGC-GUUAAGUA----- -------UUCC-ACCUGGGAAGUACGC-CCGCAAGGG-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAUCAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCU-AGGCUUGAUAUUACAGC--U-A-AACC-UCCU--GAAA---GGGA-G-GGU--- ----CC-UUCG-GG-----GAGCUG-UAACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCC-UACAA-UUAGUUACC-A UCAG-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-UA--A------------------------------------- ------------------------------------------------------------ ------------------------------------------------GC---------- --U-G---------GGGACUCUAAUUGAACU-GCCU-A----CG--CAAGU-AGAGAGGA GGGAGGGGAUGACGUCAAGUCCUC-AUGGCCCUU-ACGCCUAGGGCCACACACGUGAUAC AAUG-GCGACUACAGAGGGC---------------------------------------- ----------------------A---AA-GCCGCAAGGCAGAGGGAA-UCCC--A-AAAA AGUCGUCUCAGUCCGGAUCGGAGUCUGCAACUCGACUCCGUG-AAGUUGGAAUCGCUAGU AAUCGCGG-AUCAGC-AUGCCGCGGUGAAUGUGUUCCCGGGCCUUGUACACACCGCCCGU CAAGUCAUGGAAG-UCAGGAGU-ACCCAAAGACGC------------------------- ----U-CG-C----------------------------------------GCGUUU-AAG GUAAGACUGGUAACUGGGACUAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGCGGCUGG AUCACCUCCUUU---------- >Coxiella_burnetii -------------AUUGAAGAGUUUGAUUCUG-GCUCAGAUUGA-ACGCUAGCGGC-A-U GC-UUAACACAUGCAAGUCGAACGGCAGCGC---------GGGGAG------CU---U-G -------CUCCCU---------G--G-CG--GC-GAG-UGGCG-GACGGGUGAGUAAUGC GUAGGA-AU-CUACCUUGUAG---------------------UGGGGG-AUAACCU--G- G-GGAAA-CUCGGGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UAAUC-UC------------------------------------------- ------------------------------------------------------------ ----U-UU-G-------------GAG-CAAA-GCGGGGGAUC---------------U-- U-C-G--------------GACCUCGUGCUAUAAGAUGAGCCUACG-UCGGAUUA-GCUU --GUUGGUGGGGUAAUGGCCUA-CCAAGGCGACGAUCCGU-AGCUGGUCUGAGAGGAC-G AUCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGGACAAUGGGG-GAA----ACCCUGAUCCAGCAAUGCCGCGU--GUGUGAAGAAGG CC--UU-CG--GGUU-GU-AAAG-CACUUUCGGUGGGGAAGAAAUUCUCAAGG--GUAAU A-U-CCUUGG-GCGUUGACGUUACCCACAG-AAGAAGCACU-GGCUA-ACU-CUGUGCCA GCAGCCGCGGUAAUACAGAGAGUGCAAGCGUUAAUCGGAAUCACUGGGCGUAAAGCGCGC GUAGGUGGAUAUU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCGGAUGUGAAAGCCCUGGGCUUAACC- --------------------------------UGGG-AA-UUGCACCCGAUACUGGGU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AUCUU--GAGUAUGGUA G-AGGGAAGUGGAA-UUUCCGGUGUAGCGGUGAAAUGCGUAGAUAUCGGAAAGAACACCA GUGGCGAAGGCGACUUCCUGGACCAAUACUGACACUGAGGCGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAGACCCUG-GUAGUCCACGCCGUCAACGAUGA-GAACUAGCUGUUGGGAA G----------------------------------------------------------- ----UUCA---------------------------------------------------- ----------------------CUUCUUAGU-AGCGAAGCUAACGC-GUUAAGUU----- -------CUCC-GCCUGGGGAGUACGG-CCGCAAGGU-UAAAACUCAAAGAAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAUGCAACGCGAAAAA-CCUU- A-CCU-ACCCUUGACAUCCUC-G--G-A-ACUU-GUCA--GAGA---UGAU-U-UGGUG- ----CC-UUCG-GG----AACCGAG-UGACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGUAACGAGCGCAACCCU-CGUCC-UUAGUUGCC-A GCGA-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-CA--A------------------------------------- ------------------------------------------------------------ ------------------------------------------------GU---------- --C-G---------GGAACUCUAAGGAGACU-GCCG-G----UGA-UAAAC-CG-GAGGA AGGUGGGGAUGAUGUCAAGUCAUC-AUGGCCCUU-ACGGGUAGGGCUACACACGUGCUAC AAUG-GGCAGUACAAAGGGU---------------------------------------- ----------------------U-GCCAAGCCGCGAGGUGGAGCUAA-UCCC--A-GAAA ACUGCUCGUAGUCCGGAUUGGAGUCUGCAACUCGACUCCAUG-AAGUUGGAAUCGCUAGU AAUCGCGA-AUCAGC-AUGUCGCGGUGAAUACGUUCUCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UGAAUUGU-ACCAGAAGCGGGUAGGCUAACC--------------- ----U-UC-G----------------------GGAGGCCG----------CUCACC-ACG GUAUGAUCCAUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCUUACU-------- >Crocosphaera_watsonii --------AACACCAUGGAGAGUUUGAUCCUG-GCUCAGGAUGA-ACGCUGGCGGU-A-U GC-CUAACACAUGCAAGUCGAACGAAG-----------------UC------UU---C-G -------GA----------------------CU-UAG-UGGCG-GACGGGUGAGUAACGC GUGAGA-AU-CUGCCUUGAGG---------------------AUGGGG-ACAACAG--U- U-GGAAA-CGACUGCUAAUACCCGA----------------------------------- ------------------------------------------------------------ ---------UGU-G-CC------------------------------------------- ------------------------------------------------------------ ----G-GA-A-------------GGU-GAAA-AU-----------------------U-- U-U----------------------UUGCCUCAAGAGGAGCUCGCG-UCUGAUUA-GCUA --GUUGGUGGGGUAAAAGCGUA-CCAAGGCAACGAUCAGU-AGCUGGUCUGAGAGGAU-G AGCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UUUUCCGCAAUGGGC-GAA----AGCCUGACGGAGCAAUACCGCGU--GAGGGAGGAAGG CC--UU-UG--GGUU-GU-AAAC-CUCUUUUCUCAGGGAAGA-------------AGA-U C--------------UGACGGUACCUGAGG-AAUAAGCAUC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGAUGCAAGCGUUAUCCGGAAUUAUUGGGCGUAAAGCGUCC GCAGGUGGUCUUU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUCUGCUGUCAAAGACCAGAGCUUAACU- --------------------------------CUGG-GC-AGGCGGUGGAAACUGAGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUA--GAGUUCGGUA G-GGGUAGCGGGAA-UUCCCAGUGUAGCGGUGAAAUGCGUAGAUAUUGGGAAGAACAUCG GUGGCGAAGGCGUGCUACUGGACCGAAACUGACACUCAGGGACGAAAGCUAGGGUAGCGA AAGGGAUUAGAUACCCCU-GUAGUCCUAGCUGUAAACGAUGG-AAACUAGGUGUGGCUUG U----------------------------------------------------------- ---AUCGAC--------------------------------------------------- ----------------------CCGAGCCGU-GCCGUAGCCAACGC-GUUAAGUU----- -------UCCC-GCCUGGGGAGUACGC-ACGCAAGUG-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGUAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCA-GGGCUUGACAUGUCC-G--G-A-ACUU-UUCU--GAAA---GGAG-A-AGGUG- ----CC-UUCG-GG----AACCGGA-ACACAGG-UGGUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-CGUCU-UUAGUUGCC-A GCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-AA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------G---------- --U-G---------GGCACUCUAGAGAGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGAGGAUGACGUCAAGUCAGC-AUGCCCCUU-ACGCCCUGGGCUACACACGUACUAC AAUG-GUUGGGACAAAGGGC---------------------------------------- ----------------------A-GCGAACCCGCGAGGGAGAGCGAA-UCUC--AUCAAA CCCAGCCUCAGUUCAGAUUGCUCUCUGCAACUCGAGAGCAUG-AAGGAGGAAUCGCUAGU AAUCGCAG-GUCAGC-AUACUGCGGUGAAUUCGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGAAG-CUGGUCAC-GCCCGAAGUAGUUACCCUAACU--------------- ----U-UC-G----------------------GGAGGGGG----------ACUCCU-AAG GCAGGGCUAGUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGUGGCUGG AUCACCUCCUU----------- >Cytophaga_hutchinsonii ---------UUACAAUGGAGAGUUUGAUCCUG-GCUCAGGAUGA-ACGCUAGCGGC-A-G GC-CUAAUACAUGCAAGUCGAGGGGCAGCGG----------GG-UA------GC---A-A -------UA-CU----------G--C-CG--GC-GAC-CGGCG-CACGGGUGCGUAACAC GUAUGCAAC-CUACCUUAAAC---------------------UGGGAG-AUAGCCC--G- G-GGAAA-CUCGGAUUAAUACCCCA----------------------------------- ------------------------------------------------------------ ---------UAACACAUUUGUG-UC----------------------------------- ------------------------------------------------------------ ----U-CA-U---GAC-AU-GAUUGU-UAAA-GA-----------------------U-- U-U-A--------------------UCGGUUUAAGAUGGGCAUGCG-UUCGAUUA-GCUA --GUUGGUGAGGUAAUGGCUCA-CCAAGGCUACGAUCGAU-AGGGGGUCUGAGAGGAU-G AUCCCCCACACUGGUACUGAGAUACGGACCAGACUCCUACGG-GAGGCAGCAGUAGGGAA UAUUGGUCAAUGGAG-GCA----ACUCUGAACCAGCCAUGCCGCGU--GUAGGAAGAAGG CGU-UC-UG--CGUU-GU-AAAC-UACUUUUGAUUGGGAACAAAUGACUCU----UG--C G-----AGAG-UAGCUGAGUGUACCAAUAG-AAUAAGCCAC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGUGGCAAGCGUUGUCCGGAUUUAUUGGGUUUAAAGGGUGC GUAGGCGGCUUAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCAGUGGUGAAAGCCGAUCGCUUAACG- --------------------------------AUCG-AA-CUGCCAUUGAUACUGCUA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUU--GAGUAUAGAU G-AGGUAGGCGGAA-UUGACAGUGUAGCGGUGAAAUGCAUAGAUAUUGUCAAGAACACCA AUUGCGAAGGCAGCUUACUAAGUUAUAACUGACGCUGAGGCACGAAAGUGCGGGGAUCAA ACAGGAUUAGAUACCCUG-GUAGUCCGCACCGUAAACGAUGA-UCACUCGCUGUGUGCGA ------------------------------------------------------------ ----UAAA---------------------------------------------------- -----------------------CAGUACGC-GGCCAAGCGAAAGC-GAUAAGUG----- -------AUCC-ACCUGGGGAGUACGC-CCGCAAGGG-UGAAACUCAAAGGAAUUGACGG GGGUCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAUGAUACGCGAGGAA-CCUU- A-CCU-AGGCUAGAAUGUGAA-G--G-A-AUGU-AUCA--GAAA---UGGU-G-CAGU-- ----CA-GCAA-UG-----ACCUGA-AACAAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG CC-GUGAGGUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCC-UAUCU-UUAGUUGCC-A GCGA-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-UA--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------GU---------- --C-G---------GGGACUCUAGAGAGACU-GCCU-G----UG--UAAAC-AGAGAGGA AGGAGGGGACGACGUCAAGUCAUC-AUGGCCCUU-ACGCCUAGGGCUACACACGUGCUAC AAUG-GCGCAUACAGAGUGU---------------------------------------- ----------------------U-GCAAGCUAGUGAUAGCAAGCCAA-UCAC--A-AAAA GUGCGUCUCAGUUCGGAUUGAAGUCUGCAACUCGACUUCAUG-AAGCUGGAAUCGCUAGU AAUCGCGU-AUCAGCAAUGACGCGGUGAAUACGUUCCCGGACCUUGUACACACCGCCCGU CAAGCCAUGAAAG-UCUGGUGG-ACCUGAAGGCCGUAACC-------------------- ----G-CA-A--------------------------GGAG----------CGGCUC-AGG GUAAAACAGGUAAUUAGGGCUAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGCGGCUGG AACACCUCCUUUCU-------- >Dechloromonas_aromatica ------------------AGAGUUUGAUCCUG-GCUCAGAUUGA-ACGCUGGCGGC-A-U GC-CUUACACAUGCAAGUCGAACGGCAGCAC-----------GGGA------GC---A-A -------UCCU-----------G--G-UG--GC-GAG-UGGCG-AACGGGUGAGUAAUAU AUCGGA-AC-GUACCUUUCAG---------------------UGGGGG-AUAACGU--A- G-CGAAA-GUUACGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UAUUC-UG------------------------------------------- ------------------------------------------------------------ ----U-GA-G-------------CAG-GAAA-GCAGGGGAUC---------------G-- C-A-A--------------GACCUUGCGCUGAUUGAGCGGCCGAUA-UCAGAUUA-GCUA --GUUGGUGAGGUAAAGGCUCA-CCAAGGCGACGAUCUGU-AGCGGGUCUGAGAGGAU-G AUCCGCCACACUGGAACUGAGACACGGUCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UUUUGGACAAUGGGG-GCA----ACCCUGAUCCAGCCAUGCCGCGU--GAGUGAAGAAGG CC--UU-CG--GGUU-GU-AAAG-CUCUUUCAGCCGGGAAGAAAACGCAUGGG--UUAAU A-C-CCUGUG-UGGAUGACGGUACCGGAAU-AAGAAGCACC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGGUGCGAGCGUUAAUCGGAAUUACUGGGCGUAAAGCGUGC GCAGGCGGUUUGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGAUAGGCGUGAAAUCCCCGGGCUCAACC- --------------------------------UGGG-AA-CUGCGUUUAUGACUGGCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GAGUAUGGCA G-AGGGGGGUGGAA-UUCCACGUGUAGCAGUGAAAUGCGUAGAGAUGUGGAGGAACACCG AUGGCGAAGGCAGCCCCCUGGGCCAAUACUGACGCUCAUGCACGAAAGCGUGGGUAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCCUAAACGAUGU-CAACUAGGUGUUGGGAG G----------------------------------------------------------- ---GUAAA---------------------------------------------------- ---------------------ACCUUUUAGU-ACCGGAGCUAACGC-GUGAAGUU----- -------GACC-GCCUGGGGAGUACGG-CCGCAAGGU-UAAAACUCAAAGGAAUUGACGG GGACCCGC-ACAA-GCGGUGGAUGAUGUGGAUUAAUUCGAUGCAACGCGAAAAA-CCUU- A-CCU-ACCCUUGACAUGUCC-G--G-A-AGCC-CUUA--GAGA---UUUG-G-GUGUGC ----UC-GAAA-GA---GAGCCGGA-ACACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UGUCG-UUAAUUGCC-A UCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-UA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUUUAACGAGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCCUC-AUGGCCCUU-AUGGGUAGGGCUUCACACGUCAUAC AAUG-GUCGGUACAAAGGGU---------------------------------------- ----------------------U-GCCAACCCGCGAGGGGGAGCUAA-UCCC--A-GAAA GCCGAUCGUAGUCCGGAUCGUAGGCUGCAACUCGCCUGCGUG-AAGUCGGAAUCGCUAGU AAUCGUGG-AUCAGC-AUGUCACGGUGAAUACGUUCCCGGGUCUUGUACACACCGCCCGU CACACCAUGGGAG-CGGGUUCC-GCCAGAAGUAGGUAGCCUAACC--------------- ----G-CA-A----------------------GGGGGGCG----------CUUACC-ACG GCGGGGUUCGUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCUU----------- >Dehalococcoides_ethenogenes -----------AGCUUGGAGAGUUUGAUCCUG-GCUCAGGAUGA-ACGCUAGCGGC-G-U GC-CUUAUGCAUGCAAGUCGAACGGUC-U--------------UAA------GC---A-A -------UUA------------------A--GA-UAG-UGGCA-AACGGGUGAGUAACGC GUAAGUAAC-CUACCUCUAAG---------------------UGGGGG-AUAGCUU--C- G-GGAAA-CUGAAGGUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UGUGAUGGGCU-G-AC----------------------------------- ------------------------------------------------------------ ----A-UA-A---GUC--G-GUUCAU-UAAA-GCC----------------------G-- C-A-A-------------------GGUGCUUGGUGAGGGGCUUGCG-UCCGAUUA-GCUA --GUUGGUGGGGUAAUGGCCUA-CCAAGGCUUCGAUCGGU-AGCUGGUCUGAGAGGAU-G AUCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGCAAGGAA UCUUGGGCAAUGGGC-GAA----AGCCUGACCCAGCAACGCCGCGU--GAGGGAUGAAGG CU--UU-CG--GGUU-GU-AAAC-CUCUUUUCACAGGGAAGA-------------AU--A A--------------UGACGGUACCUGUGG-AAUAAGCUUC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGAAGCAAGCGUUAUCCGGAUUUAUUGGGCGUAAAGUGAGC GUAGGUGGUCUUU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUUGGAUGUGAAAUUUCCCGGCUUAACC- --------------------------------GGGA-CG-UGUCAUUCAAUACUGUUG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUA--GAGUACAGCA G-GAGAAAACGGAA-UUCCCGGUGUAGUGGUAAAAUGCGUAGAUAUCGGGAGGAACACCA GAGGCGAAGGCGGUUUUCUAGGUUGUCACUGACACUGAGGCUCGAAAGCGUGGGGAGCGA ACAGAAUUAGAUACUCUG-GUAGUCCACGCCUUAAACUAUGG-ACACUAGGUAUAGGGAG U----------------------------------------------------------- ---AUCGAC--------------------------------------------------- ----------------------CCUCUCUGU-GCCGAAGCUAACGC-UUUAAGUG----- -------UCCC-GCCUGGGGAGUACGG-UCGCAAGGC-UAAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCAGCGGAGCGUGUGGUUUAAUUCGAUGCUACACGAAGAA-CCUU- A-CCA-AGAUUUGACAUGCAUGA--A-GUAGUG-AACC--GAAA---GGGA-A-ACGACC U---GU-UAAG-UC---AGGAGUUU-GCACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG CC-GUGAGGUGUUUGGUUAAGUCCUGCAACGAGCGCAACCCU-UGUUG-CUAGUUA---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------A-AU---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --U-U--------------UCUAGCGAGACU-GCCC-C----GCG-AAACG-GG-GAGGA AGGUGGGGAUGACGUCAAGUCAGC-AUGGCCUUU-AUAUCUUGGGCUACACACACGCUAC AAUG-GACAGAACAAUAGGU---------------------------------------- ----------------------U-GCAACAGUGUGAACUGGAGCUAA-UCCC--C--AAA GCUGUCCUCAGUUCGGAUUGCAGGCUGAAACCCGCCUGCAUG-AAGUUGGAGUUGCUAGU AACCGCAU-AUCAGC-AAGGUGCGGUGAAUACGUUCUCGGGCCUUGUACACACCGCCCGU CACGUCAUGAAAG-CCGGUAAC-ACUUGAAGUCGAUGUGCCAACC--------------- ----G-CA-A----------------------GGAGGCAG----------UCGCCG-AGG GUGGGACUGGUAAUUGGGACGAAGUCGUAACAAGGUAGCCGUAGCGGAAGCUGCGGCUGG AUCACCUCCUUU---------- >Deinococcus_radiodurans -----------UUUAUGGAGAGUUUGAUCCUG-GCUCAGGGUGA-ACGCUGGCGGC-G-U GC-UUAAGACAUGCAAGUCGAACGCGG-----------------UC------UU---C-G -------GA----------------------CC-GAG-UGGCG-CACGGGUGAGUAACAC GUAACUGAC-CUACCCAGAAG---------------------UCACGA-AUAACUG--G- C-CGAAA-GGUCCGCUAAUACGUGA----------------------------------- ------------------------------------------------------------ ---------UGUGGUGAUG--C-AC----------------------------------- ------------------------------------------------------------ ----C-GU-G---GUG----CAUCAC-UAAA-GA-----------------------U-- U-U-A--------------------UCGCUUCUGGAUGGGGUUGCG-UUCCAUCA-GCUG --GUUGGUGGGGUAAAGGCCUA-CCAAGGCGACGACGGAU-AGCCGGCCUGAGAGGGU-G GCCGGCCACAGGGGCACUGAGACACGGGUCCCACUCCUACGG-GAGGCAGCAGUUAGGAA UCUUCCACAAUGGGC-GCA----AGCCUGAUGGAGCGACGCCGCGU--GAGGGAUGAAGG UU--UU-CG--GAUC-GU-AAAC-CUCUGAA-UCUGGGACGAAAGAGCC------UU--A G-------GG-CAGAUGACGGUACCAGAGU-AAU-AGCACC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGGUGCAAGCGUUACCCGGAAUCACUGGGCGUAAAGGGCGU GUAGGCGGAAAUU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUGGUUUUAAAGACCGGGGCUCAACC- --------------------------------UCGG-GG-AUGGACUGGAUACUGGAU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------UUCUU--GACCUCUGGA G-AGGUAACUGGAA-UUCCUGGUGUAGCGGUGGAAUGCGUAGAUACCAGGAGGAACACCA AUGGCGAAGGCAAGUUACUGGACAGAAGGUGACGCUGAGGCGCGAAAGUGUGGGGAGCAA ACCGGAUUAGAUACCCGG-GUAGUCCACACCCUAAACGAUGU-ACGUUGGCUAAGCGCAG ------------------------------------------------------------ ----GAUG---------------------------------------------------- -----------------------CUGUGCUU-GGCGAAGCUAACGC-GAUAAACG----- -------UACC-GCCUGGGAAGUACGG-CCGCAAGGU-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGAAGAA-CCUU- A-CCA-GGUCUUGACAUGCUA-G--G-A-ACUU-UGCA--GAGA---UGCA-G-AGGUGC ----CC-UUCG-GG---GAACCUAG-ACACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UGCCU-UUAGUUGUC-A GCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-CA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GACACUCUAGAGGGACU-GCCU-A----UGA--AAGU-AG-GAGGA AGGCGGGGAUGACGUCUAGUCAGC-AUGGUCCUU-ACGUCCUGGGCGACACACGUGCUAC AAUG-GGUAGGACAACGCGC---------------------------------------- ----------------------A-GCAAACCCGCGAGGGUAAGCGAA-UCGC--U-AAAA CCUAUCCCCAGUUCAGAUCGGAGUCUGCAACUCGACUCCGUG-AAGUUGGAAUCGCUAGU AAUCGCGG-GUCAGC-AUACCGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UAGAUUGC-AGUUGAAACCGCCGGG-AG-CU--------------- ----U-UG-C----------------------GG---CAG----------GCGUCU-AGA CUGUGGUUUAUGACUGGGGUGAAGUCGUAACAAGGUAACUGUACCGGAAGGUGCGGUUGG AUCACCUCCUUU---------- >Escherichia_coli -----------AAAUUGAAGAGUUUGAUCAUG-GCUCAGAUUGA-ACGCUGGCGGC-A-G GC-CUAACACAUGCAAGUCGAACGGUAACAGG--------AAGAAG------CU---U-G -------CUUCUU--------UG--C-UG--AC-GAG-UGGCG-GACGGGUGAGUAAUGU CUGGGA-AA-CUGCCUGAUGG---------------------AGGGGG-AUAACUA--C- U-GGAAA-CGGUAGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UAACG-UC------------------------------------------- ------------------------------------------------------------ ----G-CA-A-------------GAC-CAAA-GAGGGGGACC---------------U-- U-C-G--------------GGCCUCUUGCCAUCGGAUGUGCCCAGA-UGGGAUUA-GCUA --GUAGGUGGGGUAACGGCUCA-CCUAGGCGACGAUCCCU-AGCUGGUCUGAGAGGAU-G ACCAGCCACACUGGAACUGAGACACGGUCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGCACAAUGGGC-GCA----AGCCUGAUGCAGCCAUGCCGCGU--GUAUGAAGAAGG CC--UU-CG--GGUU-GU-AAAG-UACUUUCAGCGGGGAGGAAGGGAGUAAAG--UUAAU A-C-CUUUGC-UCAUUGACGUUACCCGCAG-AAGAAGCACC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGGUGCAAGCGUUAAUCGGAAUUACUGGGCGUAAAGCGCAC GCAGGCGGUUUGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCAGAUGUGAAAUCCCCGGGCUCAACC- --------------------------------UGGG-AA-CUGCAUCUGAUACUGGCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AGCUU--GAGUCUCGUA G-AGGGGGGUAGAA-UUCCAGGUGUAGCGGUGAAAUGCGUAGAGAUCUGGAGGAAUACCG GUGGCGAAGGCGGCCCCCUGGACGAAGACUGACGCUCAGGUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGU-CGACUUGGAGGUUGUGC C----------------------------------------------------------- ---CUUGA---------------------------------------------------- ----------------------GGCGUGGCU-UCCGGAGCUAACGC-GUUAAGUC----- -------GACC-GCCUGGGGAGUACGG-CCGCAAGGU-UAAAACUCAAAUGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCU-GGUCUUGACAUCCAC-G--G-A-AGUU-UUCA--GAGA---UGAG-A-AUGUG- ----CC-UUCG-GG----AACCGUG-AGACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UU-GUGAAAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UAUCC-UUUGUUGCC-A GCGG-------------------------------------------------------- ------------------------------------------------------------ ----------------U-CC--G---G--------------------------------- ------------------------------------------------------------ -------------------------------------------------C---------- --C-G---------GGAACUCAAAGGAGACU-GCCA-G----UGA-UAAAC-UG-GAGGA AGGUGGGGAUGACGUCAAGUCAUC-AUGGCCCUU-ACGACCAGGGCUACACACGUGCUAC AAUG-GCGCAUACAAAGAGA---------------------------------------- ----------------------A-GCGACCUCGCGAGAGCAAGCGGA-CCUC--A-UAAA GUGCGUCGUAGUCCGGAUUGGAGUCUGCAACUCGACUCCAUG-AAGUCGGAAUCGCUAGU AAUCGUGG-AUCAGA-AUGCCACGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UGGGUUGC-AAAAGAAGUAGGUAGCUUAACC--------------- ----U-UC-G----------------------GGAGGGCG----------CUUACC-ACU UUGUGAUUCAUGACUGGGGUGAAGUCGUAACAAGGUAACCGUAGGGGAACCUGCGGUUGG AUCACCUCCUUA---------- >Fusobacterium_nucleatum ---------AUUGAACGAAGAGUUUGAUCCUG-GCUCAGGAUGA-ACGCUGACAGA-A-U GC-UUAACACAUGCAAGUCU-ACUUGA-AUU---------UGGGUU------UU---U-U -------AACUUC------------G-AU--UU-GGG-UGGCG-GACGGGUGAGUAACGC GUAAAGAAU-UUGCCUCACAG---------------------CUAGGG-ACAACAU--U- U-GGAAA-CGAAUGCUAAUACCUGA----------------------------------- ------------------------------------------------------------ ---------UAUUAUGAUUAUA-GG----------------------------------- ------------------------------------------------------------ ----G-CA-U---CCU-AG-AAUUAU-GAAA-GCU----------------------A-- U-A---------------------UGCGCUGUGAGAGAGCUUUGCG-UCCCAUUA-GCUA --GUUGGAGAGGUAACGGCUCA-CCAAGGCGAUGAUGGGU-AGCCGGCCUGAGAGGGU-G AACGGCCACAAGGGGACUGAGACACGGCCCUUACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGGACAAUGGACCGAG----AGUCUGAUCCAGCAAUUCUGUGU--GCACGAUGACGU UU--UU-CG--GAAU-GU-AAAG-UGCUUUCAGUUGGGAAGAA------------AA--A A-------------AUGACGGUACCAACAG-AAGAAGUGAC-GGCUA-AAU-ACGUGCCA GCAGCCGCGGUAAUACGUAUGUCACGAGCGUUAUCCGGAUUUAUUGGGCGUAAAGCGCGU CUAGGUGGUUAUG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUGAUGUGAAAAUGCAGGGCUCAACU- --------------------------------CUGU-AU--UGCGUUGGAAACUGUGU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AACUA--GAGUACUGGA G-AGGUAAGCGGAA-CUACAAGUGUAGAGGUGAAAUUCGUAGAUAUUUGUAGGAAUGCCG AUGGGGAAGCCAGCUUACUGGACAGAUACUGACGCUGAAGCGCGAAAGCGUGGGUAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGA-UUACUAGGUGUUGGGGG ------------------------------------------------------------ ----UCGA---------------------------------------------------- -----------------------ACCUCAGC-GCCCAAGCAAACGC-GAUAAGUA----- -------AUCC-GCCUGGGGAGUACGU-ACGCAAGUA-UGAAACUCAAAGGAAUUGACGG GGACCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGACGCAACGCGAGGAA-CCUU- A-CCA-GCGUUUGACAUCUUA-G--G-A-AUGA-GACA--GAGA---UGUU-U-CAGUGU C---CC-UUCG-GG--GAAACCUAA-AGACAGG-UGGUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCC-UUUCG-UAUGUUACC-A UCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-AA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGGACUCAUGCGAUACU-GCCU-A----CGA-UGAGU-AG-GAGGA AGGUGGGGAUGACGUCAAGUCAUC-AUGCCCCUU-AUACGCUGGGCUACACACGUGCUAC AAUG-GGUAGAACAGAGAGU---------------------------------------- ----------------------U-GCAAAGCCGUGAGGUGGAGCUAA-UCUC--A-GAAA ACUAUUCUUAGUUCGGAUUGUACUCUGCAACUCGAGUACAUG-AAGUUGGAAUCGCUAGU AAUCGCGA-AUCAGCAAUGUCGCGGUGAAUACGUUCUCGGGUCUUGUACACACCGCCCGU CACACCACGAGAG-UUGGUUGC-ACCUGAAGUAGCAGGCCUAACC--------------- ----G-UA-A----------------------GGAGGGAU----------GUUCCG-AGG GUGUGAUUAGCGAUUGGGGUGAAGUCGUAACAAGGUAUCCGUACGGGAACGUGCGGUUGG AUCACCUCCU------------ >Geobacillus_kaustophilus ----------------GGAGAGUUUGAUCCUG-GCUCAGGACGA-ACGCUGGCGGC-G-U GC-CUAAUACAUGCAAGUCGAGCGGAC-CAA--------AUCGGAG------CU---U-G -------CUCUGAU-----------U-UG--GU-CAG-CGGCG-GACGGGUGAGUAACAC GUGGGCAAC-CUGCCCGCAAG---------------------ACCGGG-AUAACUC--C- G-GGAAA-CCGGAGCUAAUACCGGA----------------------------------- ------------------------------------------------------------ ---------UAACA-CCGAAGA-CC----------------------------------- ------------------------------------------------------------ ----G-CA-U---GGU-CU-UUGGUU-GAAA-GGCGGCC------------------U-- U-U-G----------------GCUGUCACUUGCGGAUGGGCCCGCG-GCGCAUUA-GCUA --GUUGGUGAGGUAACGGCUCA-CCAAGGCGACGAUGCGU-AGCCGGCCUGAGAGGGU-G ACCGGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUAGGGAA UCUUCCGCAAUGGGC-GAA----AGCCUGACGGAGCGACGCCGCGU--GAGCGAAGAAGG CC--UU-CG--GGUC-GU-AAAG-CUCUGUUGUGAGGGACGAAGGAGCGCCGUUCGAA-G A--GGGCGGC-GCGGUGACGGUACCUCACG-AGGAAGCCCC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGGGGCGAGCGUUGUCCGGAAUUAUUGGGCGUAAAGCGCGC GCAGGCGGUUCCU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUGAUGUGAAAGCCCACGGCUCAACC- --------------------------------GUGG-AG-GGUCAUUGGAAACUGGGG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUU--GAGUGCAGGA G-AGGAGAGCGGAA-UUCCACGUGUAGCGGUGAAAUGCGUAGAGAUGUGGAGGAACACCA GUGGCGAAGGCGGCUCUCUGGCCUGCAACUGACGCUGAGGCGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGA-GUGCUAAGUGUUAGAGG G----------------------------------------------------------- ---GUCAC---------------------------------------------------- ---------------------ACCCUUUAGU-GCUGCAGCUAACGC-GAUAAGCA----- -------CUCC-GCCUGGGGAGUACGG-CCGCAAGGC-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGAAGAA-CCUU- A-CCA-GGUCUUGACAUCCCU-U--G-A-CAAC-CCAA--GAGA---UUGG-G-CGUUCC C---CC-UUCG-GG--GGGACAGGG-UGACAGG-UGGUGCAUGGUUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-CGCCU-CUAGUUGCC-A GCAC-------------------------------------------------------- ------------------------------------------------------------ ----------------G-AA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------G---------- --U-G---------GGCACUCUAGAGGGACU-GCCG-G----CGA-CAAGU-CG-GAGGA AGGUGGGGAUGACGUCAAAUCAUC-AUGCCCCUU-AUGACCUGGGCUACACACGUGCUAC AAUG-GGCGGUACAAAGGGC---------------------------------------- ----------------------U-GCGAACCCGCGAGGGGGAGCGAA-UCCC--A-AAAA GCCGCUCUCAGUUCGGAUUGCAGGCUGCAACUCGCCUGCAUG-AAGCCGGAAUCGCUAGU AAUCGCGG-AUCAGC-AUGCCGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCACGAGAG-CUUGCAAC-ACCCGAAGUCGGUGCGGUAACCC-------------- ----U-UA-C---------------------GGGAGCCAG----------CCGCCG-AAG GUGGGGCAAGUGAUUGGGGUGAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGCGGCUGG AUCACCUCCUUUC--------- >Geobacter_sulfurreducens -----------AAACUGGAGAGUUUGAUCCUG-GCUCAGAACGA-ACGCUGGCGGC-G-U GC-CUAACACAUGCAAGUCGAACGUGA-UCC-----------AUCC------UU---C-G -------GGGU--------------G-GU--GA-AAG-UGGCG-CACGGGUGAGUAACGC GUGGAUAAU-CUGCCCGAGGA---------------------UUUGGG-AUAACAU--C- U-CGAAA-GGGGUGCUAAUACCGAA----------------------------------- ------------------------------------------------------------ ---------UAAGCCCACGGGG-UC----------------------------------- ------------------------------------------------------------ ----U-AC-G---GAU-CU-UGCGGG-AAAA-GGGGGGGACU---------------U-- U-C-G--------------GGCCUCCUGUCUUCGGAUGAGUCCGCG-UACCAUUA-GCUA --GUUGGUAGGGUAAUGGCCUA-CCAAGGCGACGAUGGUU-AGCUGGUCUGAGAGGAU-G AUCAGCCACACUGGAACUGAGACACGGUCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UUUUGCGCAAUGGGG-GAA----ACCCUGACGCAGCAACGCCGCGU--GGGUGAUGAAGG CC--UU-CG--GGUC-GU-AAAG-CCCUGUCGGGAGGGAAGAAAUGAUUGAGAG-CUAAU A-C-CUCUUG-GUCUUGACGGUACCUCCGA-AGGAAGCACC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGGUGCAAGCGUUGUUCGGAAUUAUUGGGCGUAAAGCGCGU GUAGGCGGUCUUU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUGAUGUGAAAGCCCCGGGCUCAACC- --------------------------------UGGG-AA-GUGCAUUGGAAACUGGGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUU--GAGUACGGGA G-AGGAGAGUGGAA-UUCCUAGUGUAGGAGUGAAAUCCGUAGAUAUUAGGAGGAACACCG GUGGCGAAGGCGGCUCUCUGGACCGAUACUGACGCUGAGACGCGAAAGCGUGGGUAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGA-GUACUAGGUGUUGCGGG U----------------------------------------------------------- ---AUUGAC--------------------------------------------------- ----------------------CCCUGCAGU-GCCGUAGCUAACGC-AUUAAGUA----- -------CUCC-GCCUGGGAAGUACGG-UCGCAAGAC-UAAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGACGCAACGCGCAGAA-CCUU- A-CCU-GGGCUUGACAUCCAC-G--G-A-ACCC-UCCC--GAAA---CGGA-G-GGGUGC ----CC-UUCG-GG---GAGCCGUG-AGACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UAUCA-UCAGUUGCC-A UCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-AA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUGAUGAAACU-GCCG-G----UGU-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCCUC-AUGGCCCUU-AUGUCCAGGGCUACACACGUGCUAC AAUG-GCCGGUACAAAGAGU---------------------------------------- ----------------------C-GCAAUGCCGCGAGGUGGAGCCAA-UCUC--A-AAAA GCCGGUCUCAGUUCGGAUUGGAGUCUGCAACUCGACUCCAUG-AAGUCGGAAUCGCUAGU AAUCGCGG-AUCAGC-AUGCCGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCACGGGAG-UCGACUGG-UCCCGAAGUGCGUGAGCUAACCA-------------- ----G-CA-A---------------------UGGAGGCAG----------CGUCCU-AAG GAAUGGUCGGUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCUUU---------- >Gloeobacter_violaceus --------ACCAAAAUGGAGAGUUUGAUCCUG-GCUCAGGAUGA-ACGCUGGCGGC-G-U GC-UUAACGCAUGCAAGUCGAACGAGA-----------------UC------UU---C-G -------GA----------------------UC-GAG-UGGCG-GACGGGUGAGUAACAC GUGGGA-AU-CUGCCCUCAGG---------------------AGGGGG-AUAACGG--C- C-GGAAA-CGGCCGCUAAUACCCCA----------------------------------- ------------------------------------------------------------ ---------UAU-G-CC------------------------------------------- ------------------------------------------------------------ ----G-CA-A-------------GGU-GAAAUGA-----------------------A-- U-U----------------------UCGCCUGAGGAUGAGCCCGCG-UCUGAUUA-GCUA --GUUGGUGGGGUAAUGGCCUA-CCAAGGCUACGAUCAGU-AGCUGGUCUGAGAGGAU-G AUCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UUUUCCGCAAUGGGC-GAA----AGCCUGACGGAGCAACGCCGCGU--GGGUGAUGAAGG CC--CG-UG--GGUC-GU-AAAG-CCCUUUUGUCAGGGACGA-------------AA--C C--------------UGACGGUACCUGACG-AAUAAGCAUC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGAUGCAAGCGUUAUCCGGAAUUAUUGGGCGUAAAGCGUAC GUAGGCGGCCAGC----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUCUGGGGUCAAAGCCCGCAGCCUAACU- --------------------------------GCGG-AA-AGGCCCUGGAAACUGGUU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GAGUGCGGUA G-GGGCAAGGGGAA-UUCCCGGUGUAGCGGUGAAAUGUGGAGAUAUCGGGAAGAACACCA GCGGCGAAAGCGCCUUGCUGGACCGCAACUGACGCUGAGGUACGAAAGCCAGGGGAGCAA AUGGGAUUAGAUACCCCA-GUAGUCCUGGCCGUAAACGAUGG-ACACUAGGUGUUGCGCG U----------------------------------------------------------- ---AUCGAC--------------------------------------------------- ----------------------CCGUGCAGU-GCCGUAGCUAACGC-GUUAAGUG----- -------UCCC-GCCUGGGGAGUACGC-ACGCAAGUG-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCA-GGGCUUGACAUGUCG-C--G-A-AUCU-CGCG--GAAA---CGUG-G-GAGUG- ----CC-UUCG-GG----AACGCGA-ACACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-CGUCG-UCAGUUGCC-A UCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-CA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUGGCGAGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCAGC-AUGGCUCUU-ACGUCCUGGGCUACACACGUGCUAC AAUG-GUUCGGAUAAAGGGU---------------------------------------- ----------------------C-GCAAUCUCGCGAGGGGGAGCCAA-UCCC--A-UAAA CCGAAUCUCAGUUCGGAUUGCAGGCUGCAACUCGCCUGCAUG-AAGUCGGAAUCGCUAGU AAUCGCAG-GUCAGC-AUACUGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGAAG-CUGGUCAU-GCCCGAAGUCGGUAUUCUAACC--------------- ----G-CA-A----------------------GGAGGGAG----------CCGCCG-AAG GCGGGGCCGGUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGCGGCUGG AUCACCUCCUUU---------- >Gluconobacter_oxydans -----------------GAGAGUUUGAUCCUG-GCUCAGAGCGA-ACGCUGGCGGC-A-U GC-UUAACACAUGCAAGUCGCACGAAG-----------------GU------UU---C-G -------GC----------------------CU-UAG-UGGCG-GACGGGUGAGUAACGC GUAGGG-AU-CUAUCCACGGG---------------------UGGGGG-ACAACUU--C- G-GGAAA-CUGGAGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UGAUA-CC------------------------------------------- ------------------------------------------------------------ ----U-GA-G-------------GGU-CAAA-GGC----------------------G-- C-A-A-------------------GUCGCCUGUGGAGGAACCUGCG-UUCGAUUA-GCUA --GUUGGUGGGGUAAAGGCCUA-CCAAGGCGAUGAUCGAU-AGCUGGUUUGAGAGGAU-G AUCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGGACAAUGGGC-GAA----AGCCUGAUCCAGCAAUGCCGCGU--GUGUGAAGAAGG UC--UU-CG--GAUU-GU-AAAG-CACUUUCGACGGGGACGA-------------UG--- A--------------UGACGGUACCCGUAG-AAGAAGCCCC-GGCUA-ACU-UCGUGCCA GCAGCCGCGGUAAUACGAAGGGGGCUAGCGUUGCUCGGAAUGACUGGGCGUAAAGGGCGC GUAGGCGGUUGUU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------ACAGUCAGAUGUGAAAUCCCCGGGCUUAACC- --------------------------------UGGG-AA-CUGCAUUUGAUACGUGAC-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUA--GAGUUCGAGA G-AGGGUUGUGGAA-UUCCCAGUGUAGAGGUGAAAUUCGUAGAUAUUGGGAAGAACACCG GUGGCGAAGGCGGCAACCUGGCUCGAUACUGACGCUGAGGCGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCUGUAAACGAUGU-GUGCUGGAUGUUGGGAA A----------------------------------------------------------- ---CUUAG---------------------------------------------------- ----------------------UUUCUCAGU-GUCGAAGCUAACGC-GCUAAGCA----- -------CACC-GCCUGGGGAGUACGG-CCGCAAGGU-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGCAGAA-CCUU- A-CCA-GGGCUUG-CAUGGGG-A--GGA-CCGG-UUCA--GAGA---UGGA-C-CUUU-- -----C-UUCG-G-----ACCUCCC-GCACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UGUCU-UUAGUUGCC-A GCAC-------------------------------------------------------- ------------------------------------------------------------ ------------U---U-UC--A------------------------------------- ------------------------------------------------------------ ------------------------------------------------GG---------- --U-G---------GGCACUCUAGAGAGACU-GCCG-G----UGA-CAAGC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCCUC-AUGGCCCUU-AUGUCCUGGGCUACACACGUGCUAC AAUG-GCGGUGACAGUGGGA---------------------------------------- ----------------------A-GCUACAUGGUGACAUGGUGCUGA-UCUC--U--AAA AGCCGUCUCAGUUCGGAUUGUACUCUGCAACUCGAGUACAUG-AAGGUGGAAUCGCUAGU AAUCGCGG-AUCAGC-AUGCCGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UUGGUUCG-ACCUUAAGCCGGUGAGCGAACC--------------- ----G-CA-A----------------------GGACGCAG----------CCGACC-ACG GACGGGUCAGCGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCUUU---------- >Haemophilus_influenzae ------------AAUUGAAGAGUUUGAUCAUG-GCUCAGAUUGA-ACGCUGGCGGC-A-G GC-UUAACACAUGCAAGUCGAACGGUAGCAG--------GAGAAAG------CU---U-G -------CUUUCUU--------G--C-UG--AC-GAG-UGGCG-GACGGGUGAGUAAUGC UUGGGA-AU-CUGGCUUAUGG---------------------AGGGGG-AUAACGA--C- G-GGAAA-CUGUCGCUAAUACCGCG----------------------------------- ------------------------------------------------------------ ---------UAUUA-UC------------------------------------------- ------------------------------------------------------------ ----G-GA-A-------------GAU-GAAA-GUGCGGGACU---------------G-- A-G-A--------------GGCCGCAUGCCAUAGGAUGAGCCCAAG-UGGGAUUA-GGUA --GUUGGUGGGGUAAAUGCCUA-CCAAGCCUGCGAUCUCU-AGCUGGUCUGAGAGGAU-G ACCAGCCACACUGGAACUGAGACACGGUCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGCGCAAUGGGG-GGA----ACCCUGACGCAGCCAUGCCGCGU--GAAUGAAGAAGG CC--UU-CG--GGUU-GU-AAAG-UUCUUUCGGUAUUGAGGAA-GGUUGAUGUG-UUAAU A-G-UACAUC-AAAUUGACGUUAAAUACAG-AAGAAGCACC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGGUGCGAGCGUUAAUCGGAAUAACUGGGCGUAAAGGGCAC GCAGGCGGUUAUU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUGAGGUGUGAAAGCCCUGGGCUUAACC- --------------------------------UAGG-AA-UUGCAUUUCAGACUGGGU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AACUA--GAGUACUUUA G-GGAGGGGUAGAA-UUCCACGUGUAGCGGUGAAAUGCGUAGAGAUGUGGAGGAAUACCG AAGGCGAAGGCAGCCCCUUGGGAAUGUACUGACGCUCAUGUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCUGUAAACGCUGU-CGAUUUGGGGAUUGGGC ------------------------------------------------------------ ---UUAGA---------------------------------------------------- -----------------------GCUUGGUG-CCCGUAGCUAACGU-GAUAAAUC----- -------GACC-GCCUGGGGAGUACGG-CCGCAAGGU-UAAAACUCAAAUGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCU-ACUCUUGACAUCCUA-A--G-A-AGAG-CUCA--GAGA---UGAG-C-UUGUG- ----CC-UUCG-GG----AACUUAG-AGACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UU-GUGAAAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UAUCC-UUUGUUGCC-A GCGA-------------------------------------------------------- ------------------------------------------------------------ ------------C---U-UG--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --C-G---------GGAACUCAAAGGAGACU-GCCA-G----UGA-UAAAC-UG-GAGGA AGGUGGGGAUGACGUCAAGUCAUC-AUGGCCCUU-ACGAGUAGGGCUACACACGUGCUAC AAUG-GCGUAUACAGAGGGA---------------------------------------- ----------------------A-GCGAAGCUGCGAGGUGGAGCGAA-UCUC--A-UAAA GUACGUCUAAGUCCGGAUUGGAGUCUGCAACUCGACUCCAUG-AAGUCGGAAUCGCUAGU AAUCGCGA-AUCAGA-AUGUCGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UGGGUUGU-ACCAGAAGUAGAUAGCUUAACC--------------- ----U-UU-U----------------------GGAGGGCG----------UUUACC-ACG GUAUGAUUCAUGACUGGGGUGAAGUCGUAACAAGGUAACCGUAGGGGAACCUGCGGUUGG AUCACCUCCUUA---------- >Helicobacter_hepaticus ------------------AGAGUUUGAUCCUG-GCUCAGAGUGA-ACGCUGGCGGC-G-U GC-CUAAUACAUGCAAGUCGAACGAUG-AAU-------C-UUCUAG------CU---U-G -------CUAGAA-G----------U-GG--AU-UAG-UGGCG-CACGGGUGAGUAAUGC AUAGGUUAU-GUGCCCUUUAG---------------------UCUGGG-AUAGCCA--C- U-GGAAA-CGGUGAUUAAUACUGGA----------------------------------- ------------------------------------------------------------ ---------UACUC-CC------------------------------------------- ------------------------------------------------------------ ----U-AC-G-------------GGG-GAAA-GU-----------------------U-- U-U----------------------UCGCUAAAGGAUCAGCCUAUG-UCCUAUCA-GCUU --GUUGGUGAGGUAAUGGCUCA-CCAAGGCUAUGACGGGU-AUCCGGCCUGAGAGGGU-G AUCGGACACACUGGAACUGAGACACGGUCCAGACUCCUACGG-GAGGCAGCAGUAGGGAA UAUUGCUCAAUGGGG-GAA----ACCCUGAAGCAGCAACGCCGCGU--GGAGGAUGAAGG UU--UU-AG--GAUU-GU-AAAC-UCCUUUUGUUAGAGAAGA-------------UU--- A--------------UGACGGUAUCUAACG-AAUAAGCACC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGGUGCAAGCGUUACUCGGAAUCACUGGGCGUAAAGAGUGC GUAGGCGGGGUAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCAGAUGUGAAAUCCUGUAGCUUAACU- --------------------------------ACAG-AA-CUGCAUUUGAAACUGUUA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------CUCUG--GAGUGUGGGA G-AGGUAGGUGGAA-UUCUUGGUGUAGGGGUAAAAUCCGUAGAGAUCAAGAGGAAUACUC AUUGCGAAGGCGACCUGCUGGAACAUUACUGACGCUGAUGCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCCUAAACGAUGG-AUGCUAGUUGUUGCCUU G----------------------------------------------------------- ---CUUGU---------------------------------------------------- ----------------------CAGGGCAGU-AAUGCAGCUAACGC-AUUAAGCA----- -------UCCC-GCCUGGGGAGUACGG-UCGCAAGAU-UAAAACUCAAAGGAAUAGACGG GGACCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGAUACGCGAAGAA-CCUU- A-CCU-AGGCUUGACAUUGAU-A--G-A-AUCU-ACUA--GAGA---UAGU-G-GAGUGC C---C--UUCG--G-GG-AGCUUGA-AAACAGG-UGCUGCACGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-CGUCC-UUAGUUGCU-A GCAG-------------------------------------------------------- ------------------------------------------------------------ ----------------U-UC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------------GC---------- --U-G---------AGCACUCUAAGGAGACU-GCCU-U----CG--UAAGG-AG-GAGGA AGGUGAGGACGACGUCAAGUCAUC-AUGGCCCUU-ACGCCUAGGGCUACACACGUGCUAC AAUG-GGGCGCACAAAGAGG---------------------------------------- ----------------------A-GCAAUAUCGCGAGGUGGAGCAAA-UCUC--A--AAA ACGUCUCUCAGUUCGGAUUGUAGUCUGCAACUCGACUACAUG-AAGCUGGAAUCGCUAGU AAUCGUGA-AUCAGCCAUGUCACGGUGAAUACGUUCCCGGGUCUUGUACUCACCGCCCGU CACACCAUGGGAG-UUGUAUUC-GCCUUAAGUCGGGAUACUAA----------------- ----A-UU---------------------------GGUUA----------CCGCCC-ACG GCGGAUGCAGCGACUGGGGUGAAGUCGUAACAAGGUAACCGUAGGUGAACCUGCGGUUGG AUCACCUCCU------------ >Legionella_pneumophila ----------------GAAGAGUUUGAUCCUG-GCUCAGAUUGA-ACGCUGGCGGC-A-U GC-UUAACACAUGCAAGUCGAACGGCAGCAU--------UGUCUAG------CU---U-G -------CUAGGCA--------G--A-UG--GC-GAG-UGGCG-AACGGGUGAGUAACGC GUAGGA-AU-AUGCCUUGAAG---------------------AGGGGG-ACAACUU--G- G-GGAAA-CUCAAGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UAAUG-UC------------------------------------------- ------------------------------------------------------------ ----U-GA-G-------------GAC-GAAA-GCUGGGGACC---------------U-- U-C-G--------------GGCCUGGCGCUUUAAGAUUAGCCUGCG-UCCGAUUA-GCUA --GUUGGUGGGGUAAGGGCCUA-CCAAGGCGACGAUCGGU-AGCUGGUCUGAGAGGAU-G ACCAGCCACACUGGAACUGAGACACGGUCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGGACAAUGGGG-GCA----ACCCUGAUCCAGCAAUGCCGCGU--GUGUGAAGAAGG CC--UG-AG--GGUU-GU-AAAG-CACUUUCAGUGGGGAGGAG-GGUUGAUAGG-UUAAG A-G-CUGAUU-AACUGGACGUUACCCACAG-AAGAAGCACC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGGUGCAAGCGUUAAUCGGAAUUACUGGGCGUAAAGGGUGC GUAGGUGGUUGAU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUUAUCUGUGAAAUUCCUGGGCUUAACC- --------------------------------UGGG-AC-GGUCAGAUAAUACUGGUU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUC--GAGUAUGGGA G-AGGGUAGUGGAA-UUUCCGGUGUAGCGGUGAAAUGCGUAGAGAUCGGAAGGAACACCA GUGGCGAAGGCGGCUACCUGGCCUAAUACUGACACUGAGGCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCUGUAAACGAUGU-CAACUAGCUGUUGGUUA U----------------------------------------------------------- ---AUGAAA--------------------------------------------------- ----------------------AUAAUUAGU-GGCGCAGCAAACGC-GAUAAGUU----- -------GACC-GCCUGGGGAGUACGG-UCGCAAGAU-UAAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCU-ACCCUUGACAUACAG-U--G-A-AUUU-UGCA--GAGA---UGCA-U-UAGUG- ----CC-UUCG-GG----AACACUG-AUACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGUAACGAGCGCAACCCU-UAUCC-UUAGUUGCC-A GCAU-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-GA--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------GG---------- --U-G---------GGGACUCUAAGGAGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGCGGGGAUGACGUCAAGUCAUC-AUGGCCCUU-ACGGGUAGGGCUACACACGUGCUAC AAUG-GCCGAUACAGAGGGC---------------------------------------- ----------------------G-GCGAAGGGGCGACCUGGAGCAAA-UCCU--U-AAAA GUCGGUCGUAGUCCGGAUUGGAGUCUGCAACUCGACUCCAUG-AAGUCGGAAUCGCUAGU AAUCGCGA-AUCAGC-AUGUCGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UGGGUUGC-ACCAGAAGUAGAUAGUCUAACC--------------- ----U-UC-G----------------------GGGGGACG----------UUUACC-ACG GUGUGGUUCAUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCU--------------- >Leifsonia_xyli ---------------CGGAGAGUUUGAUCCUG-GCUCAGGACGA-ACGCUGGCGGC-G-U GC-UUAACACAUGCAAGUCGAACGAUG-AAC---------CAGGAG------CU---U-G -------CUCUUG------------G-GA--AU-UAG-UGGCG-AACGGGUGAGUAACAC GUGAGUAAC-CUGCCCUUGAC---------------------UCUGGG-AUAACCU--C- C-GGAAA-CGGAAGCUAAUACCGGA----------------------------------- ------------------------------------------------------------ ---------UACGA-ACCGCGG-AG----------------------------------- ------------------------------------------------------------ ----G-CA-U---CUCCAG-CGGUUG-GAAA-GA-----------------------A-- C-U----------------------UCGGUCGAGGAUGGACUCGCG-GCCUAUCA-GGUA --GUUGGUGAGGUAACGGCUCA-CCAAGCCUACGACGGGU-AGCCGGCCUGAGAGGGU-G ACCGGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGCACAAUGGGC-GAA----AGCCUGAUGCAGCAACGCCGCGU--GAGGGAUGACGG CC--UU-CG--GGUU-GU-AAAC-CUCUUUUAGUAGGGAAGAA-GC---------GA--A A-----------G--UGACGGUACCUGCAG-AAAAAGCACC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGGUGCGAGCGUUGUCCGGAAUUAUUGGGCGUAAAGAGCUC GUAGGCGGUCUGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CGCGUCUGCUGUGAAAACCCGAGGCUCAACC- --------------------------------UCGG-GC-CUGCAGUGGGUACGGGCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUA--GAGUGCGGUA G-GGGAGAAUGGAA-UUCCUGGUGUAGCGGUGGAAUGCGCAGAUAUCAGGAGGAACACCG AUGGCGAAGGCAGUUCUCUGGGCCGUAACUGACGCUGAGGAGCGAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGUUGG-GCGCUAGAUGUGGGGAC C----------------------------------------------------------- --AUUCCAC--------------------------------------------------- ----------------------GGUUUCCGU-GUCGCAGCUAACGC-AUUAAGCG----- -------CCCC-GCCUGGGGAGUACGG-CCGCAAGGC-UAAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGCGGAGCAUGCGGAUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCA-AGGCUUGACAUAUACGA--G-A-ACGG-GCUA--GAAA---UAGU-C-AAC--- ----UC-UUUG-GA----CACUCGU-AAACAGG-UGGUGCAUGGUUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-CGUUC-UAUGUUGCC-A GCAC-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-AA--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------GG---------- --U-G---------GGAACUCAUAGGAGACU-GCCG-G----GGU-CAACU-CG-GAGGA AGGUGGGGAUGACGUCAAAUCAUC-AUGCCCCUU-AUGUCUUGGGCUUCACGCAUGCUAC AAUG-GCCGGUACAAAGGGC---------------------------------------- ----------------------U-GCAAUACCGUAAGGUGGAGCGAA-UCCC--A-AAAA GCCGGUCUCAGUUCGGAUUGAGGUCUGCAACUCGACCUCAUG-AAGUCGGAGUCGCUAGU AAUCGCAG-AUCAGCAACGCUGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CAAGUCAUGAAAG-UCGGUAAC-ACCCGAAGCCGGUGGCCCAACC--------------- ----C-UU-GU---------------------GGAGGGAG----------CCGUCG-AAG GUGGGGUCGGUGAUUAGGACUAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGCGGCUGG AUCACCUCCUUUC--------- >Listeria_monocytogenes -----------------GAGAGUUUGAUCCUG-GCUCAGGACGA-ACGCUGGCGGC-G-U GC-CUAAUACAUGCAAGUCGAACGAAC-GGA--------GGAAGAG------CU---U-G -------CUCUUCC-----------A-AA--GU-UAG-UGGCG-GACGGGUGAGUAACAC GUGGGCAAC-CUGCCUGUAAG---------------------UUGGGG-AUAACUC--C- G-GGAAA-CCGGGGCUAAUACCGAA----------------------------------- ------------------------------------------------------------ ---------UGAUA-AAGUGUG-GC----------------------------------- ------------------------------------------------------------ ----G-CA-U---GCC-AC-GCUUUU-GAAA-GAUGGU-------------------U-- U-C-G----------------GCUAUCGCUUACAGAUGGGCCCGCG-GUGCAUUA-GCUA --GUUGGUAGGGUAAUGGCCUA-CCAAGGCAACGAUGCAU-AGCCGACCUGAGAGGGU-G AUCGGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUAGGGAA UCUUCCGCAAUGGAC-GAA----AGUCUGACGGAGCAACGCCGCGU--GUAUGAAGAAGG UU--UU-CG--GAUC-GU-AAAG-UACUGUUGUUAGAGAAGAACAAGGAUAAGA-GUA-A C-U-GCUUGU-CCCUUGACGGUAUCUAACC-AGAAAGCCAC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGUGGCAAGCGUUGUCCGGAUUUAUUGGGCGUAAAGCGCGC GCAGGCGGUCUUU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUGAUGUGAAAGCCCCCGGCUUAACC- --------------------------------GGGG-AG-GGUCAUUGGAAACUGGAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUG--GAGUGCAGAA G-AGGAGAGUGGAA-UUCCACGUGUAGCGGUGAAAUGCGUAGAUAUGUGGAGGAACACCA GUGGCGAAGGCGACUCUCUGGUCUGUAACUGACGCUGAGGCGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGA-GUGCUAAGUGUUAGGGG G----------------------------------------------------------- ---UUUCC---------------------------------------------------- ---------------------GCCCCUUAGU-GCUGCAGCUAACGC-AUUAAGCA----- -------CUCC-GCCUGGGGAGUACGA-CCGCAAGGU-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGAAGAA-CCUU- A-CCA-GGUCUUGACAUCCUU-U--G-A-CCAC-UCUG--GAGA---CAGA-G-CUUUC- ----CC-UUCG-GG----GACAAAG-UGACAGG-UGGUGCAUGGUUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UGAUU-UUAGUUGCC-A GCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-UA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUAAAGUGACU-GCCG-G----UG--CAAGC-CG-GAGGA AGGUGGGGAUGACGUCAAAUCAUC-AUGCCCCUU-AUGACCUGGGCUACACACGUGCUAC AAUG-GAUAGUACAAAGGGU---------------------------------------- ----------------------C-GCGAAGCCGCGAGGUGGAGCUAA-UCCC--A-UAAA ACUAUUCUCAGUUCGGAUUGUAGGCUGCAACUCGCCUACAUG-AAGCCGGAAUCGCUAGU AAUCGUGG-AUCAGC-AUGCCACGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCACGAGAG-UUUGUAAC-ACCCGAAGUCGGUAGGGUAACCU-------------- ----U-UA-----------------------UGGAGCCAG----------CCGCCG-AAG GUGGGACAGAUAAUUGGGGUGAAGUCGUAACAAGGUAGCCGUAUCGGAAGGUGCGGCUGG AUCACCUCCUUUCU-------- >Magnetococcus_sp. ------------------AGAGUUUGAUCCUG-GCUCAGAACGA-ACGUUGGUGGC-A-U GC-UUAACACAUGCAAGUCGAACGGUAGCAG-----------GCCC------UU---C-G -------GGGU-----------G--C-UG--AC-GAG-UGGCG-CACGGGUGAGUAACGC GUGGAUGAC-CUACCCAGAUG---------------------UGGGGG-ACAACAG--U- U-GGAAA-CGACUGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UAAUC-CC------------------------------------------- ------------------------------------------------------------ ----U-AA-G-------------GGG-GAAA-GGC----------------------U-- U-A-G-------------------GCCGCAUUUGGAGGGGUCCGCG-UUGGAUUA-GGUA --GUUGGUGGGGUAAAGGCCUA-CCAAGCCGACGAUCCAU-AGCUGGUCUGAGAGGAU-G AUCAGCCACACUGGAACUGAGACACGGUCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGCGCAAUGGGG-GAA----ACCCUGACGCAGCAAUGCCACGU--GAAUGAUGAAGG CC--UU-CG--GGUU-GU-AAAG-UUCUUUUAGUAGGGAAGA-------------UA--- G--------------UGACGGUACCUACAG-AAAAAGCUCC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGGGGCAAACGUUGUUCGGAAUCACUGGGCGUAAAGGGCGC GUAGGCGGUUAUC----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGCCAGAAGUGAAAUCUCGGGGCUCAACC- --------------------------------UCGA-AA-CUGCUUUUGGAACUGGAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUA--GAAUCCGGUA G-AGGAUGGUGGAA-UUCCCCGUGUAGAGGUGAAAUUCGUAGAUAUGGGGAGGAACACCG GAGGCGAAGGCGGCCAUCUGGGCCGGUAUUGACGCUGAGGCGCGAAAGUGUGGGUAGCGA ACAGGAUUAGAUACCCUG-GUAGUCCACACCGUAAACGAUGA-GUGCUAGUAGUUGCGGG U----------------------------------------------------------- ---AUCGAC--------------------------------------------------- ----------------------CCCUGCGGC-UACGAAGUUAACAC-GAUAAGCA----- -------CUCC-GCCUGGGGAGUACGG-CCGCAAGGU-UAAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCU-GCUUUUGACAUCCUU-G--G-A-ACCU-UACG--GAGA---CGUA-G-GGGUGC ----UU-UUCG-GA---GAACCAAG-UGACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCC-UGCCU-UUAGUUGCC-A UCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-AA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUAGAGGAACU-GCCG-G----UGU-UAAGC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCAUC-AUGGCCCUU-AUGGGCAGGGCUACACACGUGCUAC AAUG-GCGGAUACAGAGGGC---------------------------------------- ----------------------G-GCGAAGCAGUGAUGUGGAGCGAA-UCUC--U-UAAA GUCCGUCUCAGUUCGGAUUGGAGUCUGCAACUCGACUCCAUG-AAGUUGGAAUCGCUAGU AAUCGCGG-AUCAGC-AUGCCGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UUGGUUUU-ACCCGAAGCCGGUGGCCUAACCU-------------- ----U-UC-G---------------------AGGGGGGAG----------CUGUCU-ACG GUAAGAUCAGCGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCUUU---------- >Magnetospirillum_magnetotacticum ------------------AGAGUUUGAUCCUG-GCUCAGAGCGA-ACGCUGGCGGC-A-G GC-UUAACACAUGCAAGUCGAACGGGC----------------ACC------UU---C-G -------GGU---------------------GU-CAG-UGGCA-GACGGGUGAGUAACAC GUGGGA-AC-GUGCCCUUCGG---------------------UUCGGA-AUAACUC--A- G-GGAAA-CUUGAGCUAAUACCGGA----------------------------------- ------------------------------------------------------------ ---------UACGC-CC------------------------------------------- ------------------------------------------------------------ ----U-UC-U-------------GGG-GAAA-GG-----------------------U-- U-U-A--------------------CUGCCGAAGGAUCGGCCCGCG-UCUGAUUA-GCUU --GUUGGUGGGGUAACGGCCUA-CCAAGGCGACGAUCAGU-AGCUGGUCUGAGAGGAU-G AUCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGGACAAUGGGC-GCA----AGCCUGAUCCAGCCAUGCCGCGU--GAGUGAUGAAGG CC--UU-AG--GGUU-GU-AAAG-CUCUUUUGUCCGGGACGA-------------UA--- A--------------UGACGGUACCGGAAG-AAUAAGCCCC-GGCUA-ACU-UCGUGCCA GCAGCCGCGGUAAUACGAAGGGGGCUAGCGUUGCUCGGAAUCACUGGGCGUAAAGGGCGC GUAGGCGGCCGAU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCGGGGGUGAAAGCCUGUGGCUCAACC- --------------------------------ACAG-AA-UUGCCUUCGAUACUGGUU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUU--GAGACCGGAA G-AGGACAGCGGAA-CUGCGAGUGUAGAGGUGAAAUUCGUAGAUAUUCGCAAGAACACCA GUGGCGAAGGCGGCUGUCUGGUCCGGUUCUGACGCUGAGGCGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGA-AUGCCAGCCGUUGGCCU G----------------------------------------------------------- ----CUUG---------------------------------------------------- ----------------------CAGGUCAGU-GGCGCCGCUAACGC-AUUAAGCA----- -------UUCC-GCCUGGGGAGUACGG-UCGCAAGAU-UAAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGCAGAA-CCUU- A-CCA-UCCCUUGACAUGGCA-U--G-U-UACC-UCGG--GAGA---CCGG-G-GAUCC- ----UC-UUCG-GA----GGCGUGC-ACACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCA-CGUCC-UUAGUUGCC-A UCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-CA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUAGGGAGACU-GCCG-G----UGA-UAAGC-CGCGAGGA AGGUGUGGAUGACGUCAAGUCCUC-AUGGCCCUU-ACGGGAUGGGCUACACACGUGCUAC AAUG-GCGGUGACAGUGGGA---------------------------------------- ----------------------C-GCGAAACCGCGAGGUCGAGCAAA-UCCC--C--AAA AACCGUCUCAGUUCGGAUUGCACUCUGCAACUCGGGUGCAUG-AAGGCGGAAUCGCUAGU AAUCGUGG-AUCAGC-ACGCCACGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UUGGUCUU-ACCCGACGGCGCUGCGCCAACC--------------- ----G-CA-A----------------------GGAGGCAG----------GCGACC-ACG GUAGGGUCAGCGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUG- ---------------------- >Mesoplasma_florum -----------UAAAAUGAGAGUUUGAUCCUG-GCUCAGGAUAA-ACGCUGGCGGC-A-U GC-CUAAUACAUGCAAGUCGAACGGAG----------------GUG------CU---U-G -------CAC---------------------CU-CAG-UGGCG-AACGGGUGAGUAACAC GUAUCUAAU-CUACCUUCUAG---------------------CGGGGG-AUAACUU--U- U-GGAAA-CGAAAGGUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UGUGGAUGUUAUUAUC----------------------------------- ------------------------------------------------------------ ----G-CA-U---GAG-AA-AACAUU-CAAA-GAUCC--------------------G-- U-U-U-----------------GGAUCACUAGAAGAUGAGGAUGCG-GCGUAUUA-GCUA --GUAGGCGGGGUAAAGGCCCA-CCUAGGCGAUGAUACGU-AGCCGAACUGAGAGGUU-G AUCGGCCACAUUGGGACUGAGAUACGGCCCAGACUCCUACGG-GAGGCAGCAGUAGGGAA UUUUUCACAAUGGAC-GAA----AGUCUGAUGAAGCAAUGCCGCGU--GAGUGAUGACGG CC--UU-CG--GGUU-GU-AAAG-CUCUGUUGUAAGGGAAGAAAACAUAGGAGA-GGA-A A-U-GCUCUU-AUCUUGACGGUACCUUACC-AGAAAGCCAC-GGCUA-ACU-AUGUGCCA GCAGCCGCGGUAAUACAUAGGUGGCAAGCGUUAUCCGGAUUUAUUGGGCGUAUAGGGUGC GUAGGCGGUUUCG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUUUGAGGUUAAAGCCCGGAGCUCAACU- --------------------------------CCGG-UU--CGCCUUGAAAACUGCGG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUA--GAAUAUCAGA G-AGGUAAGCGGAA-UUCCAUGUGUAGCGGUAAAAUGCGUAGAUAUAUGGAAGAACACCA GUGGCGAAAGCGGCUUACUGGCUGAUUAUUGACGCUGAGGCACGAAAGCGUGGGGAGCAA AUAGGAUUAGAUACCCUA-GUAGUCCACGCCGUAAACGUUGA-GUACUAAGUAUUGGGG- ------------------------------------------------------------ ----AUUA---------------------------------------------------- ------------------------CCUCAGU-GCUGCAGCUAACGC-AUUAAGUA----- -------CUCC-GCCUGAGUAGUAUGC-UCGCAAGAG-UGAAACUCAAAGGAAUUGACGG GGACCCGC-ACAA-GUGGUGGAGCAUGUGGUUUAAUUCGAAGCAACACGAAGAA-CCUU- A-CCA-GGGCUUGACAUACAG-U--G-C-AAAGCUACA--GAGA---UGUAGU-GGA--- -----G-GUUA-A-------CAUUG-AUACAGG-UGGUGCAUGGUUGUCGUCAGUUCGUG CC-GUGAGGUGUUGGGUUAAGUCCCGCAACGAACGCAACCCU-UGUCG-UUAGUUACU-A ACAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-AA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------AGGACUCUAACGAGACU-GCUA-G----UG--UAAGC-UA-GAGGA AGGUGGGGAUGACGUCAAAUCAUC-AUGCCCCUU-AUGUCCUGGGCUACACACGUGCUAC AAUG-GCCGAUACAAAGAGU---------------------------------------- ----------------------C-GCAAUCUCGCGAGGGGGAGCUAA-UCUC--A-AAAA GUCGGUCUCAGUUCGGAUUGAAGUCUGCAACUCGACUUCAUG-AAGCCGGAAUCACUAGU AAUCGCGA-AUCAGCUAUGUCGCGGUGAAUACGUUCUCGGGUCUUGUACACACCGCCCGU CAAACCACGAGAG-UUGGUAAU-ACCAGAAGUACGUUUCCUAACC--------------- ----G-UA-A----------------------GGAAGGCG----------CGUCCC-AAG GUAGGACUAGCGAUUGGGGUUAAGUCGUAACAAGGUAUCCGUACGGGAACGUGCGGAUGG AUCACCUCCUUU---------- >Mycobacterium_leprae ---------UUUGUUUGGAGAGUUUGAUCCUG-GCUCAGGACGA-ACGCUGGCGGC-G-U GC-UUAACACAUGCAAGUCGAACGGAA-AGG---------UC--UCUAAAAAAU---C-U -UUUUUAGA--GA------------U-AC--UC-GAG-UGGCG-AACGGGUGAGUAACAC GUGGGUAAU-CUGCCCUGCAC---------------------UUCAGGGAUAAGCU--U- G-GGAAA-CUGGGUCUAAUACCGGA----------------------------------- ------------------------------------------------------------ ---------UAGGA-CUUCAAG-GC----------------------------------- ------------------------------------------------------------ ----G-CA-U---GUC-UU-GUGGUG-GAAA-GC-----------------------U-- U-U-UU-------------------GCGGUGCAGGAUGGGCCCGCG-GCCUAUCA-GCUU --GUUGGUGGGGUGACGGCCUA-CCAAGGCGACGACGGGU-AGCCGGCCUGAGAGGGU-G UACGGCCACACUGGGACUGAGAUACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGCACAAUGGGC-GCA----AGCCUGAUGCAGCGACGCCGCGU--GGGGGAUGACGG CU--UU-CG--GGUU-GU-AAAC-CUCUUUCACCAUCGACGAAGGUCUGGG----UU--U U------CUC-GGAUUGACGGUAGGUGGAG-AAGAAGCACC-GGCCA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGGUGCGAGCGUUGUCCGGAAUUACUGGGCGUAAAGAGCUC GUAGGUGGUUUGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CGCGUUGUUCGUGAAAUCUCACGGCUUAACU- --------------------------------GUGA-GC-GUGCGGGCGAUACGGGCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUG--GAGUACUGCA G-GGGAGACUGGAA-UUCCUGGUGUAGCGGUGGAAUGCGCAGAUAUCAGGAGGAACACCA GUGGCGAAGGCGGGUCUCUGGGCAGUAACUGACGCUGAGGAGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGGUGG-GUACUAGGUGUGGGUUU C----------------------------------------------------------- --CUUCCUU--------------------------------------------------- ----------------------GGGAUCCGU-GCCGUAGCUAACGC-AUUAAGUA----- -------CCCC-GCCUGGGGAGUACGG-CCGCAAGGC-UAAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGCGGAGCAUGUGGAUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCU-GGGUUUGACAUGCACAG--G-A-UGCG-UCUA--GAGA---UAGG-C-ACU--- ----CC-CUUGUGG------CCUGU-GUGCAGG-UGGUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UGUCU-CAUGUUGCC-A GCAC-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-AA--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------GG---------- --U-G---------GGGACUCGUGAGAGACU-GCCG-C----GGU-CAACU-CG-GAGGA AGGUGGGGAUGACGUCAAGUCAUC-AUGCCCCUU-AUGUCCAGGGCUUCACACAUGCUAC AAUG-GCCGGUACAAAGGGC---------------------------------------- ----------------------U-GCGAUGCCGCAAGGUUAAGCGAA-UCCU--UUUAAA GCCGGUCUCAGUUCGGAUCGGGGUCUGCAACUCGACCCCGUG-AAGUCGGAGUCGCUAGU AAUCGCAG-AUCAGCAACGCUGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACGUCAUGAAAG-UCGGUAAC-ACCCGAAGCCAGUGGCCUAACC--------------- ----C-UC-G----------------------GGAGGGAG----------CUGUCC-AAG GUGGGAUCGGCGAUUGGGACGAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGCGGCUGG AUCACCUCCUUUCU-------- >Neisseria_gonorrhoeae -----------GAACAUAAGAGUUUGAUCCUG-GCUCAGAUUGA-ACGCUGGCGGC-A-U GC-UUUACACAUGCAAGUCGGACGGCAGCAC--------AGGGAAG------CU---U-G -------CUUCUCG--------G--G-UG--GC-GAG-UGGCG-AACGGGUGAGUAACAU AUCGGA-AC-GUACCGGGUAG---------------------CGGGGG-AUAACUG--A- U-CGAAA-GAUCAGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UACGU-CU------------------------------------------- ------------------------------------------------------------ ----U-GA-G-------------AGG-GAAA-GCAGGGGACC---------------U-- U-C-G--------------GGCCUUGCGCUAUCCGAGCGGCCGAUA-UCUGAUUA-GCUG --GUUGGCGGGGUAAAGGCCCA-CCAAGGCGACGAUCAGU-AGCGGGUCUGAGAGGAU-G AUCCGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UUUUGGACAAUGGGC-GCA----AGCCUGAUCCAGCCAUGCCGCGU--GUCUGAAGAAGG CC--UU-CG--GGUU-GU-AAAG-GACUUUUGUCAGGGAAGAA-AAGGCCGUUG-CCAAU A-U-CGGCGG-CCGAUGACGGUACCUGAAG-AAUAAGCACC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGGUGCGAGCGUUAAUCGGAAUUACUGGGCGUAAAGCGGGC GCAGACGGUUACU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGCAGGAUGUGAAAUCCCCGGGCUCAACC- --------------------------------CGGG-AA-CUGCGUUCUGAACUGGGU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUC--GAGUGUGUCA G-AGGGAGGUGGAA-UUCCACGUGUAGCAGUGAAAUGCGUAGAGAUGUGGAGGAAUACCG AUGGCGAAGGCAGCCUCCUGGGAUAACACUGACGUUCAUGUCCGAAAGCGUGGGUAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCCUAAACGAUGU-CAAUUAGCUGUUGGGCA A----------------------------------------------------------- ---CUUGA---------------------------------------------------- ----------------------UUGCUUGGU-AGCGUAGCUAACGC-GUGAAAUU----- -------GACC-GCCUGGGGAGUACGG-UCGCAAGAU-UAAAACUCAAAGGAAUUGACGG GGACCCGC-ACAA-GCGGUGGAUGAUGUGGAUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCU-GGUUUUGACAUGUGC-G--G-A-AUCC-UCCG--GAGA---CGGA-G-GAGUG- ----CC-UUCG-GG----AGCCGUA-ACACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UGUCA-UUAGUUGCC-A UCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-CG--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUAAUGAGACU-GCCG-G----UGA-CAAGC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCCUC-AUGGCCCUU-AUGACCAGGGCUUCACACGUCAUAC AAUG-GUCGGUACAGAGGGU---------------------------------------- ----------------------A-GCCAAGCCGCGAGGCGGAGCCAA-UCUC--A-CAAA ACCGAUCGUAGUCCGGAUUGCACUCUGCAACUCGAGUGCAUG-AAGUCGGAAUCGCUAGU AAUCGCAG-GUCAGC-AUACUGCGGUGAAUACGUUCCCGGGUCUUGUACACACCGCCCGU CACACCAUGGGAG-UGGGGGAU-ACCAGAAGUAGGUAGGGUAACC--------------- ----G-CA-A----------------------GGAGUCCG----------CUUACC-ACG GUAUGCUUCAUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCUUU---------- >Nitrosomonas_europaea ------------------AGAGUUUGAUCCUG-GCUCAGAUUGA-ACGCUGGCGGC-A-U GC-UUUACACAUGCAAGUCGAACGGCAGCGG-----------GGGC------UU---C-G -------GCCU-----------G--C-CG--GC-GAG-UGGCG-AACGGGUGAGUAAUAC AUCGGA-AC-GUGUCCUUAAG---------------------UGGGGA-AUAACGC--A- U-CGAAA-GAUGUGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UA-UC-UC------------------------------------------- ------------------------------------------------------------ ----U-GA-G-------------GAG-AAAA-GCAGGGGAUC---------------G-- C-A-A--------------GACCUUGCGCUAAAGGAGCGGCCGAUG-UCUGAUUA-GCUA --GUUGGUGGGGUAAAGGCUUA-CCAAGGCAACGAUCAGU-AGUUGGUCUGAGAGGAC-G GCCAACCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UUUUGGACAAUGGGC-GAA----AGCCUGAUCCAGCCAUGCCGCGU--GAGUGAAGAAGG CC--UU-CG--GGUU-GU-AAAG-CUCUUUUAGUCGGAAAGAA-AGAGUUGCAA-UGAAU A-A-UUGUGA-UUUAUGACGGUACCGACAG-AAAAAGCACC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGGUGCGAGCGUUAAUCGGAAUUACUGGGCGUAAAGGGUGC GCAGGCGGUCUUG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUCAGAUGUGAAAGCCCCGGGCUUAACC- --------------------------------UGGG-AA-UUGCGUUUGAAACUACAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GAGUGCAGCA G-AGGGGAGUGGAA-UUCCAUGUGUAGCAGUGAAAUGCGUAGAGAUGUGGAAGAACACCG AUGGCGAAGGCAGCUCCCUGGGUUGACACUGACGCUCAUGCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCCUAAACGAUGU-CAACUAGUUGUCGGAUC U----------------------------------------------------------- ---AAUUAA--------------------------------------------------- ----------------------GGAUUUGGU-AACGUAGCUAACGC-GUGAAGUU----- -------GACC-GCCUGGGGAGUACGG-UCGCAAGAU-UAAAACUCAAAGGAAUUGACGG GGACCCGC-ACAA-GCGGUGGAUUAUGUGGAUUAAUUCGAUGCAACGCGAAAAA-CCUU- A-CCU-ACCCUUGACAUGCUU-G--G-A-AUCU-AAUG--GAGA---CAUA-A-GAGUAC ----CC-GAAA-GG---GAGCCAAG-ACACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UGUCA-CUAAUUGCU-A UCAU-------------------------------------------------------- ------------------------------------------------------------ ------------U---U-UU--A------------------------------------- ------------------------------------------------------------ -------------------------------------------------A---------- --U-G---------AGCACUUUAGUGAGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCCUC-AUGGCCCUU-AUGGGUAGGGCUUCACACGUAAUAC AAUG-GCGUGUACAGAGGGU---------------------------------------- ----------------------U-GCCAACCCGCGAGGGGGAGCCAA-UCUC--A-GAAA GCACGUCGUAGUCCGGAUCGGAGUCUGCAACUCGACUCCGUG-AAGUCGGAAUCGCUAGU AAUCGCGG-AUCAGC-AUGCCGCGGUGAAUACGUUCCCGGGUCUUGUACACACCGCCCGU CACACCAUGGGAG-UGGUUUUC-ACCAGAAGCAGGUAGCUUAACC--------------- ----G-UA-A----------------------GGAGGGCG----------CUUGCC-ACG GUGGGGGUCAUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCUUUC--------- >Novosphingobium_aromaticivorans ------------------AGAGUUUGAUCCUG-GCUCAGAACGA-ACGCUGGCGGC-A-U GC-CUAACACAUGCAAGUCGAACGAAC-----------------CC------UU---C-G -------GG----------------------GU-UAG-UGGCG-CACGGGUGCGUAACGC GUGGGA-AU-CUGCCCUUUGC---------------------UUCGGA-AUAACAG--U- U-AGAAA-UGACUGCUAAUACCGGA----------------------------------- ------------------------------------------------------------ ---------UGAUG-UC------------------------------------------- ------------------------------------------------------------ ----U-UC-G-------------GAC-CAAA-GA-----------------------U-- U-U-A--------------------UCGGCAAGGGAUGAGCCCGCG-UAGGAUUA-GGUA --GUUGGUGGGGUAAAGGCCUA-CCAAGCCGACGAUCCUU-AGCUGGUCUGAGAGGAU-G AUCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGGACAAUGGGC-GCA----AGCCUGAUCCAGCAAUGCCGCGU--GAGUGAUGAAGG CC--UU-CG--GGUC-GU-AAAG-CUCUUUUACCAGGGAUGA-------------UA--- A--------------UGACAGUACCUGGAG-AAUAAGCUCC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGGAGCUAGCGUUGUUCGGAAUUACUGGGCGUAAAGCGCAC GUAGGCGGCUACU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUCAGAGGUGAAAGCCCGGGGCUCAACC- --------------------------------CCGG-AA-CUGCCUUUGAAACUAGGU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AGCUG--GAAUCUUGGA G-AGGUCAGUGGAA-UUCCGAGUGUAGAGGUGAAAUUCGUAGAUAUUCGGAAGAACACCA GUGGCGAAGGCGACUGACUGGACAAGUAUUGACGCUGAGGUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGA-UAACUAGCUGUCCGGUC A----------------------------------------------------------- ---CUUGG---------------------------------------------------- ----------------------UGAUUGGGU-GGCGCAGCUAACGC-AUUAAGUU----- -------AUCC-GCCUGGGGAGUACGG-UCGCAAGAU-UAAAACUCAAAGGAAUUGACGG GGGCCUGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGCAGAA-CCUU- A-CCA-GCGUUUGACAUCCCG-C--G-C-UACU-UCCA--GAGA---UGGA-A-GGUUC- ----CC-UUCG-GG----GACGCGG-UGACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-CGUCC-UUAGUUGCC-A UCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-UA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUAAGGAAACC-GCCG-G----UGA-UAAGC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCCUC-AUGGCCCUU-ACACGCUGGGCUACACACGUGCUAC AAUG-GCGGUGACAGUGGGC---------------------------------------- ----------------------A-GCAAGCACGCGAGUGUGAGCUAA-UCUC--C--AAA AGCCGUCUCAGUUCGGAUUGUUCUCUGCAACUCGAGAGCAUG-AAGGCGGAAUCGCUAGU AAUCGCGG-AUCAGC-AUGCCGCGGUGAAUACGUUCCCAGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UUGGGUUC-ACCCGAAGGCGUUGCGCUAACUC-------------- ----G-CA-A---------------------GAGAGGCAG----------GCGACC-ACG GUGGGCUUAGCGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCUUUCU-------- >Oceanobacillus_iheyensis -----------UUUAUGGAGAGUUUGAUCUUG-GCUCAGGACGA-ACGCUGGCGGC-G-U GC-CUAAUACAUGCAAGUCGAGCGCAU-GAA-AUUAUUUGAUUCUC------UU---C-G -------GAGUUGACGAUAAU----G-GA--AU-GAG-CGGCG-GACGGGUGAGUAACAC GUAGGCAAC-CUGCCUGUAAG---------------------ACUGGG-AUAACUC--G- U-GGAAA-CGCGAGCUAAUACCGGA----------------------------------- ------------------------------------------------------------ ---------UAACA-CUUUUUA-UC----------------------------------- ------------------------------------------------------------ ----U-CC-U---GAU-GA-GAAGUU-GAAA-GGCGGC-------------------U-- U-U-U----------------GCUGUCACUUACAGAUGGGCCUGCG-GCGCAUUA-GCUA --GUUGGUAAGGUAACGGCUUA-CCAAGGCGACGAUGCGU-AGCCGACCUGAGAGGGU-G AUCGGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUAGGGAA UCUUCCGCAAUGGAC-GAA----AGUCUGACGGAGCAACGCCGCGU--GAGUGAUGAAGG UU--UU-CG--GAUC-GU-AAAA-CUCUGUUGUUAGGGAAGAACAAGUGCCAUA-GUAAC U---GAUGGC-ACCUUGACGGUACCUAACC-AGAAAGCCAC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGUGGCAAGCGUUGUCCGGAAUUAUUGGGCGUAAAGCGCUC GCAGGCGGUUCUU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUGAUGUGAAAUCUUACGGCUCAACC- --------------------------------GUAA-AC-GUGCAUUGGAAACUGGGG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AACUU--GAGUGCAGAA G-AGGAGAGUGGAA-UUCCACGUGUAGCGGUGAAAUGCGUAGAGAUGUGGAGGAACACCA GUGGCGAAGGCGACUCUCUGGUCUGUAACUGACGCUGAGGAGCGAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGA-GUGCUAGGUGUUAGGGG G----------------------------------------------------------- ---UUUCC---------------------------------------------------- ---------------------GCCCCUUAGU-GCUGAAGUUAACGC-AUUAAGCA----- -------CUCC-GCCUGGGGAGUACGG-CCGCAAGGC-UGAAACUCAAAAGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGAAGAA-CCUU- A-CCA-GGUCUUGACAUCCUC-U--G-A-ACAC-UCUA--GAGA---UAGA-G-UUUUC- ----CC-UUCG-GG----GACAGAG-UGACAGG-UGGUGCAUGGUUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UGAUC-UUAGUUGCC-A GCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-AA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUAAGGUGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAAUCAUC-AUGCCCCUU-AUGACCUGGGCUACACACGUGCUAC AAUG-GAUGGAACAAAGGGA---------------------------------------- ----------------------A-GCGAACCCGCGAGGUCAAGCAAA-UCCC--A-CAAA ACCAUUCUCAGUUCGGAUUGUAGGCUGCAACUCGCCUACAUG-AAGCCGGAAUCGCUAGU AAUCGCGG-AUCAGC-AUGCCGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCACGAGAG-UUGGUAAC-ACCCGAAGUCGGUGAGGUAACC--------------- ----G-UA-A----------------------GGAGCCAG----------CCGCCG-AAG GUGGGACUAAUGAUUGGGGUGAAGUCGUAACAAGGUAGCCGUAUCGGAAGGUGCGGCUGG AUCACCUCCUUUCU-------- >Photorhabdus_luminescens -----------AAAUUGAAGAGUUUGAUCAUG-GCUCAGAUUGA-ACGCUGGCGGC-A-G GC-CUAACACAUGCAAGUCGGGCGGUAACAG--------GAAAGUG------CC---U-G -------CACUUUU--------G--C-UG--AC-GAG-CGGCG-GACGGGUGAGUAAUGU CUGGGG-AU-CUGCCCGAGGG---------------------CGGGGG-AUAACCA--C- U-GGAAA-CGGUGGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UAAUG-UC------------------------------------------- ------------------------------------------------------------ ----G-CG-A-------------GAC-CAAA-GUGGGGGACCU--------------G-- A-A-A-------------GGGCCUCACGCCGUCGGAUGAACCCAGA-UGGGAUUA-GCUG --GUAGGUAGGGUAAUGGCCUA-CCUAGGCGACGAUCUCU-AGCUGGUCUGAGAGGAU-G ACCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGCACAAUGGGC-GCA----AGCCUGAUGCAGCCAUGCCGCGU--GUAUGAAGAAGG CC--UU-CG--GGUU-GU-AAAG-UACUUUCAGCGGGGAGGAA-GGGUUUAGCC-UGAAG A-G-GGUUAG-AUUUUGACGUUACCCGCAG-AAGAAGCACC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGGUGCAAGCGUUAAUCGGAAUGACUGGGCGUAAAGCGCAC GCAGGCGGUCAAU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUUAGAUGUGAAAUCCCCGGGCUCAACC- --------------------------------UGGG-AA-UGGCAUCUAAGACUGGUU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUG--GAGUCUCGUA G-AGGGGGGUAGAA-UUCCAUGUGUAGCGGUGAAAUGCGUAGAGAUGUGGAGGAAUACCG GUGGCGAAGGCGGCCCCCUGGACGAAGACUGACGCUCAGGUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCUGUAAACGAUGU-CGAUUUGGAGGUUGCGG U----------------------------------------------------------- ---CUUGA---------------------------------------------------- ----------------------ACGGUGGCU-UCCGAAGCUAACGC-GUUAAAUC----- -------GACC-GCCUGGGGAGUACGG-CCGCAAGGU-UAAAACUCAAAUGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCU-ACUCUUGACAUCCUC-A--G-A-AUUU-GCUG--GAGA---CAGC-G-AAGUG- ----CC-UUAG-GG----AACUGAG-AGACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UU-GUGAAAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UAUCC-UUUGUUGCC-A GCAC-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-GA--A------------------------------------- ------------------------------------------------------------ ------------------------------------------------GG---------- --U-G---------GGAACUCAAAGGAGACU-GCCG-G----UGA-UAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCAUC-AUGGCCCUU-ACGAGUAGGGCUACACACGUGCUAC AAUG-GCGGAUACAAAGUGA---------------------------------------- ----------------------A-GCGACCUCGCGAGAGCAAGCGGA-ACAC--A-CAAA GUCUGUCGUAGUCCGGAUUGGAGUCUGCAACUCGACUCCAUG-AAGUCGGAAUCGCUAGU AAUCGUAG-AUCAGC-AUGCUACGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UGGGUUGC-AAAAGAAGUCGGUAGCUUAACC--------------- ----G-AA-A----------------------GGGGGGCG----------CUGACC-ACU UUGUGGCUCAUGACUGGGGUGAAGUCGUAACAAGGUAACCGUAGGGGAACCUGCGGUUGG AUCACCUCCUUA---------- >Polaromonas_sp. ------------------AGAGUUUGAUCCUG-GCUCAGAUUGA-ACGCUGGCGGC-A-U GC-CUUACACAUGCAAGUCGAACGGCAGCAC-----------GGGA------GC---A-A -------UCCU-----------G--G-UG--GC-GAG-UGGCG-AACGGGUGAGUAAUAU AUCGGA-AC-GUGCCCAGUCG---------------------UGGGGG-AUAACGU--A- G-AGAAA-UUUACGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UACGA-UC------------------------------------------- ------------------------------------------------------------ ----U-AA-G-------------GAU-GAAA-GCGGGGGAUC---------------G-- C-A-A--------------GACCUCGCGCGAUUGGAGCGGCUGAUA-UCAGAUUA-GGUU --GUUGGUGAGGUAAAAGCUCA-CCAAGCCGACGAUCUGU-AGCUGGUUUGAGAGAAC-G ACCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UUUUGGACAAUGGGC-GAA----AGCCUGAUCCAGCAAUGCCGCGU--GCAGGAAGAAGG CC--UU-CG--GGUU-GU-AAAC-UGCUUUUGUACGGAACGAA-ACGGCUCUUU-CUAAU A-A-AGAGGG-CUAAUGACGGUACCGUAAG-AAUAAGCACC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGGUGCGAGCGUUAAUCGGAAUUACUGGGCGUAAAGCGUGC GCAGGCGGUUAUG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGACAGUUGUGAAAUCCCCGGGCUCAACC- --------------------------------UGGG-AA-UUGCAUCUGUGACUGCAU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AGCUA--GAGUACGGUA G-AGGGGGAUGGAA-UUCCGCGUGUAGCAGUGAAAUGCGUAGAUAUGCGGAGGAACACCG AUGGCGAAGGCAAUCCCCUGGACCUGUACUGACGCUCAUGCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCCUAAACGAUGU-CAACUGGUUGUUGGGUG C----------------------------------------------------------- ----AUUA---------------------------------------------------- ----------------------GUACUCAGU-AACGAAGCUAACGC-GUGAAGUU----- -------GACC-GCCUGGGGAGUACGG-CCGCAAGGU-UGAAACUCAAAGGAAUUGACGG GGACCCGC-ACAA-GCGGUGGAUGAUGUGGUUUAAUUCGAUGCAACGCGAAAAA-CCUU- A-CCU-ACCUUUGACAUGUAC-G--G-A-AUUC-GCCA--GAGA---UGGC-U-UAGUGC ----UC-GAAA-GA---GAACCGUA-ACACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UGUCA-UUAGUUGCU-A -CAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-UA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUAAUGAGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCCUC-AUGGCCCUU-AUAGGUAGGGCUACACACGUCAUAC AAUG-GCUGGUACAGAGGGU---------------------------------------- ----------------------U-GCCAACCCGCGAGGGGGAGCUAA-UCCC--A-UAAA ACCAGUCGUAGUCCGGAUCGCAGUCUGCAACUCGACUGCGUG-AAGUCGGAAUCGCUAGU AAUCGCGG-AUCAGA-AUGUCGCGGUGAAUACGUUCCCGGGUCUUGUACACACCGCCCGU CACACCAUGGGAG-CGGGUUCU-GCCAGAAGUAGUUAGCCUAACC--------------- ----G-CA-A----------------------GGAGGGCG----------AUUACC-ACG GCAGGGUUCGUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAUCGGAAGGUGCGGCUGG AUCACCUCCUUU---------- >Porphyromonas_gingivalis -----------ACAGUGGAGAGUUUGAUCCUG-GCUCAGGAUGA-ACGCUAGCGAU-A-G GC-UUAACACAUGCAAGUCGAGGGGCAGCAU-------GAUCUUAG------CU---U-G -------CUAAGGUU-------G--A-UG--GC-GAC-CGGCG-CACGGGUGCGUAACGC GUAUGCAAC-UUGCCUUACAG---------------------AGGGGG-AUAACCC--G- U-UGAAA-GACGGACUAAAACCGCA----------------------------------- ------------------------------------------------------------ ---------UACACUUGUAUUA-UU----------------------------------- ------------------------------------------------------------ ----G-CA-U---GAU-AU-UACAAG-GAAA-UA-----------------------U-- U-U-A--------------------UAGCUGUAAGAUAGGCAUGCG-UCCCAUUA-GCUU --GUUGGUGAGGUAACGGCUCA-CCAAGGCGACGAUGGGU-AGGGGAACUGAGAGGUU-U AUCCCCCACACUGGUACUGAGACACGGACCAGACUCCUACGG-GAGGCAGCAGUGAGGAA UAUUGGUCAAUGGGC-GAG----AGCCUGAACCAGCCAAGUCGCGU--GAAGGAAGACAG UCC-UA-AG--GAUU-GU-AAAC-UUCUUUUAUACGGGAAUAACGGGCGAUA---CG--A G-----UAUU-GCAUUGAAUGUACCGUAAG-AAUAAGCAUC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGAUGCGAGCGUUAUCCGGAUUUAUUGGGUUUAAAGGGUGC GUAGGUUGUUCGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCAGCGGUGAAACCUGAGCGCUCAACG- --------------------------------UUCA-GC-CUGCCGUUGAAACUGCCG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUU--GAGUUCAGUG G-CGGCAGGCGGAA-UUCGUGGUGUAGCGGUGAAAUGCAUAGAUAUCACGAGGAACUCCG AUUGCGAAGGCAGCUUGCCAUACUGCGACUGACACUGAAGCACGAAGGCGUGGGUAUCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCAGUAAACGAUGA-UUACUAGGAGUUUGCGA ------------------------------------------------------------ ---UAUAC---------------------------------------------------- ----------------------CGUCAAGCU-UCCACAGCGAAAGC-GUUAAGUA----- -------AUCC-ACCUGGGGAGUACGC-CGGCAACGG-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGAGGAACAUGUGGUUUAAUUCGAUGAUACGCGAGGAA-CCUU- A-CCC-GGGAUUGAAAUGUAGAU--G-A-CGGA-UGGU--GAAA---ACCG-U-CUUC-- ----CC-UUCG-GG-----GCUUCU-AUGUAGG-UGCUGCAUGGUUGUCGUCAGCUCGUG CC-GUGAGGUGUCGGCUUAAGUGCCAUAACGAGCGCAACCCA-CAUCG-GUAGUUACU-A ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------U---U-UU--C---G--------------------------------- ------------------------------------------------------------ -------------------------------------------------C---------- --U-G---------AGGACUCUACCGAGACU-GCCG-U----CG--UAAGG-CGUGAGGA AGGUGUGGAUGACGUCAAAUCAGC-ACGGCCCUU-ACAUCCGGGGCGACACACGUGUUAC AAUG-GGAGGGACAAAGGGC---------------------------------------- ----------------------A-GCUACCGGGCGACCGGAUGCGAA-UCUC--U--AAA CCCUUCCCCAGUUCGGAUCGGAGUCUGCAACUCGACUCCGUG-AAGCUGGAUUCGCUAGU AAUCGCGC-AUCAGCCAUGGCGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CAAGCCAUGGGAG-UCGGGGGU-ACCUGAAGGGCGUAACC-------------------- ----G-CA-A--------------------------GGGG----------CGCACU-AGG GUAAUACCGGUGACUGGGGCUAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGCGGCUGG AACACCU--------------- >Propionibacterium_acnes ------------------AGAGUUUGAUCCUG-GCUCAGGACGA-ACGCUGGCGGC-G-U GC-UUAACACAUGCAAGUCGAACGGAA-AGG---------CCCUGC------UU---U-U -------GUGGGG------------U-GC--UC-GAG-UGGCG-AACGGGUGAGUAACAC GUGAGUAAC-CUGCCCUUGAC---------------------UUUGGG-AUAACUU--C- A-GGAAA-CUGGGGCUAAUACCGGA----------------------------------- ------------------------------------------------------------ ---------UAGGA-GCUCCUG-CU----------------------------------- ------------------------------------------------------------ ----G-CA-U---GGU-GG-GGGUUG-GAAA-GU-----------------------U-- U-C-G--------------------GCGGUUGGGGAUGGACUCGCG-GCUUAUCA-GCUU --GUUGGUGGGGUAGUGGCUUA-CCAAGGCUUUGACGGGU-AGCCGGCCUGAGAGGGU-G ACCGGCCACAUUGGGACUGAGAUACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGCACAAUGGGC-GGA----AGCCUGAUGCAGCAACGCCGCGU--GCGGGAUGACGG CC--UU-CG--GGUU-GU-AAAC-CGCUUUCGCCUGUGACGAA-GC---------GU--G A-----------G--UGACGGUAAUGGGUA-AAGAAGCACC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUGAUACGUAGGGUGCGAGCGUUGUCCGGAUUUAUUGGGCGUAAAGGGCUC GUAGGUGGUUGAU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CGCGUCGGAAGUGUAAUCUUGGGGCUUAACC- --------------------------------CUGA-GC-GUGCUUUCGAUACGGGUU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUU--GAGGAAGGUA G-GGGAGAAUGGAA-UUCCUGGUGGAGCGGUGGAAUGCGCAGAUAUCAGGAGGAACACCA GUGGCGAAGGCGGUUCUCUGGGCCUUUCCUGACGCUGAGGAGCGAAAGCGUGGGGAGCGA ACAGGCUUAGAUACCCUG-GUAGUCCACGCUGUAAACGGUGG-GUACUAGGUGUGGGGUC C----------------------------------------------------------- --AUUCCAC--------------------------------------------------- ----------------------GGGUUCCGU-GCCGUAGCUAACGC-UUUAAGUA----- -------CCCC-GCCUGGGGAGUACGG-CCGCAAGGC-UAAAACUCAAAGGAAUUGACGG GGCCCCGC-ACAA-GCGGCGGAGCAUGCGGAUUAAUUCGAUGCAACGCGUAGAA-CCUU- A-CCU-GGGUUUGACAUGGAUCG--G-G-AGUG-CUCA--GAGA---UGGG-U-GUGCC- ----UC-UUUU-GG----GGUCGGU-UCACAGG-UGGUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UGUUC-ACUGUUGCC-A GCAC-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-UA--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------GG---------- --U-G---------GGGACUCAGUGGAGACC-GCCG-G----GGU-CAACU-CG-GAGGA AGGUGGGGAUGACGUCAAGUCAUC-AUGCCCCUU-AUGUCCAGGGCUUCACGCAUGCUAC AAUG-GCUGGUACAGAGAGU---------------------------------------- ----------------------G-GCGAGCCUGUGAGGGUGAGCGAA-UCUC--G-GAAA GCCGGUCUCAGUUCGGAUUGGGGUCUGCAACUCGACCUCAUG-AAGUCGGAGUCGCUAGU AAUCGCAG-AUCAGCAACGCUGCGGUGAAUACGUUCCCGGGGCUUGUACACACCGCCCGU CAAGUCAUGAAAG-UUGGUAAC-ACCCGAAGCCGGUGGCCUAACC--------------- ----G-UU-GU---------------------GG-GGGAG----------CCGUCG-AAG GUGGGACUGGUGAUUAGGACUAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGCGGCUGG AUCACCUCCUUUCUAAGGA--- >Pseudomonas_aeruginosa --------------------AGUUUGAUCAUG-GCUCAGAUUGA-ACGCUGGCGGC-A-G GC-CUAACACAUGCAAGUCGAGCGGAU-GAA----------GGGAG------CU---U-G -------CUCCU-------------G-GA--UU-CAG-CGGCG-GACGGGUGAGUAAUGC CUAGGA-AU-CUGCCUGGUAG---------------------UGGGGG-AUAACGU--C- C-GGAAA-CGGGCGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UACGU-CC------------------------------------------- ------------------------------------------------------------ ----U-GA-G-------------GGA-GAAA-GUGGGGGAUC---------------U-- U-C-G--------------GACCUCACGCUAUCAGAUGAGCCUAGG-UCGGAUUA-GCUA --GUUGGUGGGGUAAAGGCCUA-CCAAGGCGACGAUCCGU-AACUGGUCUGAGAGGAU-G AUCAGUCACACUGGAACUGAGACACGGUCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGGACAAUGGGC-GAA----AGCCUGAUCCAGCCAUGCCGCGU--GUGUGAAGAAGG UC--UU-CG--GAUU-GU-AAAG-CACUUUAAGUUGGGAGGAA-GGGCAGUAAG-UUAAU A-C-CUUGCU-GUUUUGACGUUACCAACAG-AAUAAGCACC-GGCUA-ACU-UCGUGCCA GCAGCCGCGGUAAUACGAAGGGUGCAAGCGUUAAUCGGAAUUACUGGGCGUAAAGCGCGC GUAGGUGGUUCAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUUGGAUGUGAAAUCCCCGGGCUCAACC- --------------------------------UGGG-AA-CUGCAUCCAAAACUACUG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AGCUA--GAGUACGGUA G-AGGGUGGUGGAA-UUUCCUGUGUAGCGGUGAAAUGCGUAGAUAUAGGAAGGAACACCA GUGGCGAAGGCGACCACCUGGACUGAUACUGACACUGAGGUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGU-CGACUAGCCGUUGGGAU C----------------------------------------------------------- ---CUUGA---------------------------------------------------- ----------------------GAUCUUAGU-GGCGCAGCUAACGC-GAUAAGUC----- -------GACC-GCCUGGGGAGUACGG-CCGCAAGGU-UAAAACUCAAAUGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGAAGAA-CCUU- A-CCU-GGCCUUGACAUGCUG-A--G-A-ACUU-UCCA--GAGA---UGGA-U-UGGUG- ----CC-UUCG-GG----AACUCAG-ACACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGUAACGAGCGCAACCCU-UGUCC-UUAGUUACC-A GCAC-------------------------------------------------------- ------------------------------------------------------------ ------------C---U-CG--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------G---------- --U-G---------GGCACUCUAAGGAGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCAUC-AUGGCCCUU-ACGGCCAGGGCUACACACGUGCUAC AAUG-GUCGGUACAAAGGGU---------------------------------------- ----------------------U-GCCAAGCCGCGAGGUGGAGCUAA-UCCC--A-UAAA ACCGAUCGUAGUCCGGAUCGCAGUCUGCAACUCGACUGCGUG-AAGUCGGAAUCGCUAGU AAUCGUGA-AUCAGA-AUGUCACGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UGGGUUGC-UCCAGAAGUAGCUAGUCUAACC--------------- ----G-CA-A----------------------GGGGGACG----------GUUACC-ACG GAGUGAUUCAUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCUU----------- >Ralstonia_eutropha ------------------AGAGUUUGAUCCUG-GCUCAGAUUGA-ACGCUGGCGGC-A-U GC-CUUACACAUGCAAGUCGAACGGCAGCAC-----------GGGC------UU---C-G -------GCCU-----------G--G-UG--GC-GAG-UGGCG-AACGGGUGAGUAAUAC AUCGGA-AC-GUGCCCUGUCG---------------------UGGGGG-AUAACUA--G- U-CGAAA-GAUUAGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UACGA-CC------------------------------------------- ------------------------------------------------------------ ----U-GA-G-------------GGU-GAAA-GCGGGGGACCG--------------G-- U-A-A-------------CGGCCUCGCGCGAUAGGAGCGGCCGAUG-UCUGAUUA-GCUA --GUUGGUGGGGUAAGAGCCUA-CCAAGGCGACGAUCAGU-AGCUGGUCUGAGAGGAC-G AUCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UUUUGGACAAUGGGG-GCA----ACCCUGAUCCAGCAAUGCCGCGU--GUGUGAAGAAGG CC--UU-CG--GGUU-GU-AAAG-CACUUUUGUCCGGAAAGAA-AACCCUUGCC-CUAAU A-C-GGUGGG-GGGAUGACGGUACCGGAAG-AAUAAGCACC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGGUGCGAGCGUUAAUCGGAAUUACUGGGCGUAAAGCGUGC GCAGGCGGUUUUG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGACAGGCGUGAAAUCCCCGGGCUUAACC- --------------------------------UGGG-AA-UGGCGCUUGUGACUGCAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GAGUGUGUCA G-AGGGGGGUAGAA-UUCCACGUGUAGCAGUGAAAUGCGUAGAGAUGUGGAGGAAUACCG AUGGCGAAGGCAGCCCCCUGGGACAUGACUGACGCUCAUGCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCCUAAACGAUGU-CAACUAGUUGUUGGGGA U----------------------------------------------------------- ----UCAU---------------------------------------------------- ----------------------UUCUUCAGU-AACGUAGCUAACGC-GUGAAGUU----- -------GACC-GCCUGGGGAGUACGG-UCGCAAGAU-UAAAACUCAAAGGAAUUGACGG GGACCCGC-ACAA-GCGGUGGAUGAUGUGGAUUAAUUCGAUGCAACGCGAAAAA-CCUU- A-CCU-ACCCUUGACAUGCCA-C--U-A-ACGA-AGCA--GAGA---UGCAUU-AGGUGC ----CC-GAAA-GG---GAAAGUGG-ACACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UGUCU-CUAGUUGCU-A -C---------------------------------------------------------- ------------------------------------------------------------ ----------------G-AA--A------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----G---------GGCACUCUAGAGAGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCCUC-AUGGCCCUU-AUGGGUAGGGCUUCACACGUCAUAC AAUG-GUGCGUACAGAGGGU---------------------------------------- ----------------------U-GCCAACCCGCGAGGGGGAGCCAA-UCCC--A-GAAA ACGCAUCGUAGUCCGGAUCGUAGUCUGCAACUCGACUACGUG-AAGCUGGAAUCGCUAGU AAUCGCGG-AUCAGC-AUGCCGCGGUGAAUACGUUCCCGGGUCUUGUACACACCGCCCGU CACACCAUGGGAG-UGGGUUUU-GCCAGAAGUAGUUAGCCUAACC--------------- ----G-CA-A----------------------GGAGGGCG----------AUUACC-ACG GCAGGGUUCAUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAUCGGAAGGUGCGGUUGG AUCACCUCCUUGCGGCCGCAUG >Rhodobacter_sphaeroides ------------------AGAGUUUGAUCCUG-GCUCAGAAUGA-ACGCUGGCGGC-A-G GC-CUAACACAUGCAAGUCGAGCGAAG-----------------UC------UU---C-G -------GA----------------------CU-UAG-CGGCG-GACGGGUGAGUAACGC GUGGGA-AC-AUGCCCAAAGG---------------------UACGGA-AUAGCCC--C- G-GGAAA-CUGGGAGUAAUACCGUA----------------------------------- ------------------------------------------------------------ ---------UGUGC-CC------------------------------------------- ------------------------------------------------------------ ----U-UC-G-------------GGG-GAAA-GA-----------------------U-- U-U-A--------------------UCGCCUUUGGAUUGGCCCGCG-UUGGAUUA-GGUA --GUUGGUGGGGUAAUGGCCUA-CCAAGCCGACGAUCCAU-AGCUGGUUUGAGAGGAU-G AUCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UCUUAGACAAUGGGC-GCA----AGCCUGAUCUAGCCAUGCCGCGU--GAUCGAUGAAGG CC--UU-AG--GGUU-GU-AAAG-AUCUUUCAGGUGGGAAGA-------------UA--- A--------------UGACGGUACCACCAG-AAGAAGCCCC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGGGGCUAGCGUUAUUCGGAAUUACUGGGCGUAAAGCGCAC GUAGGCGGACUGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------AAAGUCAGGGGUGAAAUCCCGGGGCUCAACC- --------------------------------CCGG-AA-CUGCCUUUGAAACUCCCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GUCUU--GAGGUCGAGA G-AGGUGAGUGGAA-UUCCGAGUGUAGAGGUGAAAUUCGUAGAUAUUCGGAGGAACACCA GUGGCGAAGGCGGCUCACUGGCUCGAUACUGACGCUGAGGUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGA-AUGCCAGUCGUCGGGCA G----------------------------------------------------------- ----CAUG---------------------------------------------------- ----------------------CUGUUCGGU-GACACACCUAACGG-AUUAAGCA----- -------UUCC-GCCUGGGGAGUACGG-CCGCAAGGU-UAAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGCAGAA-CCUU- A-CCA-ACCCUUGACAUGGCG-A--UCG-CGGU-UCCA--GAGA---UGGU-U-CCUUC- ----AG-UUCGGCU----GGAUCGC-ACACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUCGGUUAAGUCCGGCAACGAGCGCAACCCA-CGUCC-UCAGUUGCC-A GCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-CA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUGGGGAAACU-GCCG-G----UGA-UAAGC-CG-GAGGA AGGUGUGGAUGACGUCAAGUCCUC-AUGGCCCUU-ACGGGUUGGGCUACACACGUGCUAC AAUG-GUCGGGACAGAGGGU---------------------------------------- ----------------------C-GCCAACCCGCGAGGGGGAGCCAA-UCCC--A--AAA AGCUGUCUCAGUUCGGAUUGGGGUCUGCAACUCGACCCCAUG-AAGUCGGAAUCGCUAGU AAUCGCGU-AACAGC-AUGACGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAA-UUGGUUCU-ACCCGAAGGCGGUGCGCCAACCUC------------- ----G-CA-A-G-------------------AGGAGGCAG----------CCGACC-ACG GUAGGAUCAGUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCUUU---------- >Rhodopirellula_baltica ------------------GGGGUUUGAUCCUG-GCUCAGAAUGA-ACGUUGGCGGC-A-U GG-AUUAGGCAUGCAAGUCGCACGAGA-AGC--------UGAGUAG------CU---U-G -------CUACAAA-----------G-CG--GA-CAG-UGGCG-AAAGGGAGAGUAACGU GUGGUU-AC-GUGCCCUCGAG---------------------ACCGGG-AUAGCGU--C- G-GGAAA-CUGGCAGUAAUACCGGA----------------------------------- ------------------------------------------------------------ ---------UAAUA-UC------------------------------------------- ------------------------------------------------------------ ----U-AC-G-------------GAU-CAAAUGGUG---------------------A-- G-A--------------------UUCCGCUCGAGGAUUGGACCGCA-UACUAUUA-GCUU --GUUGGUGAGGUAAUGGCUCA-CCAAGGCUGCGAUGGUU-ACCGGGUGUGAGAGCAU-G GCCCGGCUCACUGGGACUGAGACACUGCCCAGACACCUACGG-GUGGCUGCAGUCGAGAA UCUUCGGCAAUGGAC-GAA----AGUCUGACCGAGCGAUGCCGCGU--GCGGGAUGAAGG CC--CU-CG--GGUU-GU-AAAC-CGCUGUCAGUUGUUAGGAAAUGCAUGGUGG-UU--A U---CCAUCA-UGUUUGACCGAUCUUCA-G-AGGAAGGACG-GGCUA-AGU-ACGUGCCA GCAGCCGCGGUAACACGUACCGUCCAAACGUUAUUCGGUAUCACUGGGCUUAAAGCGUUC GUAGGCGGCCUAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------AAGGUGAGAUGUGAAAGCCCACGGCUCAACC- --------------------------------GUGG-AA-UUGCGUUUCAAACCACUA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUU--GAGGAAGACA G-GGGUGAUGGGAA-CUUAUGGUGGAGCGGUGAAAUGCGUUGAUAUCAUAGGGAACACCG GUGGCGAAAGCGCAUCACUGGGUCUUUUCUGACGCUGAGGAACGAAAGCUAGGGUAGCGA ACGGGAUUAGAUACCCCG-GUAGUCCUAGCCGUAAACGAUGA-GCACUAGGCUGAGGGAA C----------------------------------------------------------- ---UUCCAC--------------------------------------------------- ----------------------AUUCUCUCG-GCCGCAGGGAAACC-AUUAAGUG----- -------CUCC-GCCUGGGGAGUAUGG-UCGCAAGGC-UGAAACUCAAAGGAAUUGACGG GGGCUCAC-ACAA-GCGGUGGAGGAUGUGGCUUAAUUCGAGGCUACGCGAAGAA-CCUU- AUCCU-AGACUUGACAUGCUUGA--G---AAUCCCUAU--GAAA---GUAGAG-AGUGC- ----CC-UUCG-GG---GAGCUCUU-GCACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUCGGGUUAAGUCCCUUAACGAGCGAAACCCU-UAUCU-UUAGUUGCC-A GCGG-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-AA--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------GC---------- --C-G---------GGGACUCUAAAGAGACU-GCCG-G----UGU-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCCUC-AUGGCCUUU-AUGUCUAGGGCUGCACACGUCCUAC AAUG-GCACGGACAAACGGA---------------------------------------- ----------------------C-GCAAUACCGCGAGGUGGAGCAAA-UCCU--A-GAAA CCGUGCCUCAGUUCGGAUUGCAGGCUGCAACUCGCCUGCAUG-AAGCCGGAAUCGCUAGU AAUCGUAG-GUCAGC-AUACUACGGUGAAUGUGUUCCUGAGCCUUGUACACACCGCCCGU CAAGCCACGAAAG-UUGGGAGG-GCCCGAAGUCACCAAGCUAACCC-------------- ----G-CA-A---------------------GGGAGGCAG----------GUGCCG-AAG GUCAGCUCGACAAUUGGGACUAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCC------------- >Shewanella_oneidensis --------------------AGUUUGAUCAUG-GCUCAGAUUGA-ACGCUGGCGGC-A-G GC-CUAACACAUGCAAGUCGAGCGGCAGCAC--------GAGGGAG------UU---U-A -------CUCCUGA--------G--G-UG--GC-GAG-CGGCG-GACGGGUGAGUAAUGC CUAGGG-AU-CUGCCCAGUCG---------------------AGGGGG-AUAACAG--U- U-GGAAA-CGACUGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UACGC-CC------------------------------------------- ------------------------------------------------------------ ----U-AC-G-------------GGG-GAAA-GAGGGGGACU---------------U-- U-C-G--------------GGCCUCUCGCGAUUGGAUGAACCUAGG-UGGGAUUA-GCUA --GUUGGUGAGGUAAUGGCUCA-CCAAGGCGACGAUCCCU-AGCUGUUCUGAGAGGAU-G AUCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGCACAAUGGGG-GAA----ACCCUGAUGCAGCCAUGCCGCGU--GUGUGAAGAAGG CC--UU-CG--GGUU-GU-AAAG-CACUUUCAGUAGGGAGGAA-AGGGUAAGUC-CUAAU A-C-GACUUA-UCUGUGACGUUACCUACAG-AAGAAGGACC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGGUCCGAGCGUUAAUCGGAAUUACUGGGCGUAAAGCGUGC GCAGGCGGUUUGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGCGAGAUGUGAAAGCCCUGGGCUCAACC- --------------------------------UAGG-AA-UCGCAUUUCGAACUGACC-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AACUA--GAGUCUUGUA G-AGGGGGGUAGAA-UUCCAGGUGUAGCGGUGAAAUGCGUAGAGAUCUGGAGGAAUACCG GUGGCGAAGGCGGCCCCCUGGACAAAGACUGACGCUCAUGCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGU-CUACUCGGAGUUUGGUG U----------------------------------------------------------- ---CUUGA---------------------------------------------------- ----------------------ACACUGGGC-UCUCAAGCUAACGC-AUUAAGUA----- -------GACC-GCCUGGGGAGUACGG-CCGCAAGGU-UAAAACUCAAAUGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCU-ACUCUUGACAUCCAC-G--G-A-AGAC-UGCA--GAGA---UGCG-G-UUGUG- ----CC-UUCG-GG----AACCGUG-AGACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UU-GUGAAAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCC-UAUCC-UUAUUUGCC-A GCAC-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-AA--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------GG---------- --U-G---------GGAACUCUAGGGAGACU-GCCG-G----UGA-UAAAC-CG-GAGGA AGGUGGGGACGACGUCAAGUCAUC-AUGGCCCUU-ACGAGUAGGGCUACACACGUGCUAC AAUG-GCGAGUACAGAGGGU---------------------------------------- ----------------------U-GCAAAGCCGCGAGGUGGAGCUAA-UCUC--A-CAAA GCUCGUCGUAGUCCGGAUUGGAGUCUGCAACUCGACUCCAUG-AAGUCGGAAUCGCUAGU AAUCGUGG-AUCAGA-AUGCCACGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UGGGCUGC-AAAAGAAGUGGGUAGCUUAACC--------------- ----U-UC-G----------------------GGGGGGCG----------CUCACC-ACU UUGUGGUUCAUGACUGGGGUGAAGUCGUAACAAGGUAGCCCUAGGGGAACCUGGGGCUGG AUCACCU--------------- >Sinorhizobium_meliloti -----------CAACUUGAGAGUUUGAUCCUG-GCUCAGAACGA-ACGCUGGCGGC-A-G GC-UUAACACAUGCAAGUCGAGCGCCC------------------C------GC---A-A -------G-----------------------GG-GAG-CGGCA-GACGGGUGAGUAACGC GUGGGA-AU-CUACCCUUUUC---------------------UACGGA-AUAACGC--A- G-GGAAA-CUUGUGCUAAUACCGUA----------------------------------- ------------------------------------------------------------ ---------UGAGC-CC------------------------------------------- ------------------------------------------------------------ ----U-UC-G-------------GGG-GAAA-GA-----------------------U-- U-U-A--------------------UCGGGAAAGGAUGAGCCCGCG-UUGGAUUA-GCUA --GUUGGUGGGGUAAAGGCCUA-CCAAGGCGACGAUCCAU-AGCUGGUCUGAGAGGAU-G AUCAGCCACAUUGGGACUGAGACACGGCCCAAACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGGACAAUGGGC-GCA----AGCCUGAUCCAGCCAUGCCGCGU--GAGUGAUGAAGG CC--CU-AG--GGUU-GU-AAAG-CUCUUUCACCGGUGAAGA-------------UA--- A--------------UGACGGUAACCGGAG-AAGAAGCCCC-GGCUA-ACU-UCGUGCCA GCAGCCGCGGUAAUACGAAGGGGGCUAGCGUUGUUCGGAAUUACUGGGCGUAAAGCGCAC GUAGGCGGAUUGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUGAGGGGUGAAAUCCCAGGGCUCAACC- --------------------------------CUGG-AA-CUGCCUUUCAUACUGGCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AUCUA--GAGUCCAGAA G-AGGUGAGUGGAA-UUCCGAGUGUAGAGGUGAAAUUCGUAGAUAUUCGGAGGAACACCA GUGGCGAAGGCGGCUCACUGGUCUGGAACUGACGCUGAGGUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGA-AUGUUAGCCGUCGGGCA G----------------------------------------------------------- ---UUUA----------------------------------------------------- ----------------------CUGUUCGGU-GGCGCAGCUAACGC-AUUAAACA----- -------UUCC-GCCUGGGGAGUACGG-UCGCAAGAU-UAAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGCAGAA-CCUU- A-CCA-GCCCUUGACAUCCCG-A--UCG-CGGAUACGA--GAGA---UCGUAU-CCUUC- ----AG-UUCGGCU----GGAUCGG-AGACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-CGCCC-UUAGUUGCC-A GCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-CA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUAAGGGGACU-GCCG-G----UGA-UAAGC-CGAGAGGA AGGUGGGGAUGACGUCAAGUCCUC-AUGGCCCUU-ACGGGCUGGGCUACACACGUGCUAC AAUG-GUGGUGACAGUGGGC---------------------------------------- ----------------------A-GCGAGACCGCGAGGUCGAGCUAA-UCUC--C--AAA AGCCAUCUCAGUUCGGAUUGCACUCUGCAACUCGAGUGCAUG-AAGUUGGAAUCGCUAGU AAUCGCAG-AUCAGC-AUGCUGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UUGGUUCU-ACCCGAAGGUAGUGCGCUAACC--------------- ----G-CA-A----------------------GGAGGCAG----------CUAACC-ACG GUAGGGUCAGCGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCUU----------- >Staphylococcus_aureus ----------UUUUAUGGAGAGUUUGAUCCUG-GCUCAGGAUGA-ACGCUGGCGGC-G-U GC-CUAAUACAUGCAAGUCGAGCGAAC-GGA--------CGAGAAG------CU---U-G -------CUUCUCU-----------G-AU--GU-UAG-CGGCG-GACGGGUGAGUAACAC GUGGAUAAC-CUACCUAUAAG---------------------ACUGGG-AUAACUU--C- G-GGAAA-CCGGAGCUAAUACCGGA----------------------------------- ------------------------------------------------------------ ---------UAAUA-UUUUGAA-CC----------------------------------- ------------------------------------------------------------ ----G-CA-U---GGU-UC-AAAAGU-GAAA-GACGGU-------------------C-- U-U------------------GCUGUCACUUAUAGAUGGAUCCGCG-CUGCAUUA-GCUA --GUUGGUAAGGUAACGGCUUA-CCAAGGCAACGAUGCAU-AGCCGACCUGAGAGGGU-G AUCGGCCACACUGGAACUGAGACACGGUCCAGACUCCUACGG-GAGGCAGCAGUAGGGAA UCUUCCGCAAUGGGC-GAA----AGCCUGACGGAGCAACGCCGCGU--GAGUGAUGAAGG UC--UU-CG--GAUC-GU-AAAA-CUCUGUUAUUAGGGAAGAACAUAUGUGUAA-GUA-A C-U-GUGCAC-AUCUUGACGGUACCUAAUC-AGAAAGCCAC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGUGGCAAGCGUUAUCCGGAAUUAUUGGGCGUAAAGCGCGC GUAGGCGGUUUUU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUGAUGUGAAAGCCCACGGCUCAACC- --------------------------------GUGG-AG-GGUCAUUGGAAACUGGAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AACUU--GAGUGCAGAA G-AGGAAAGUGGAA-UUCCAUGUGUAGCGGUGAAAUGCGCAGAGAUAUGGAGGAACACCA GUGGCGAAGGCGACUUUCUGGUCUGUAACUGACGCUGAUGUGCGAAAGCGUGGGGAUCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGA-GUGCUAAGUGUUAGGGG G----------------------------------------------------------- ---UUUCC---------------------------------------------------- ---------------------GCCCCUUAGU-GCUGCAGCUAACGC-AUUAAGCA----- -------CUCC-GCCUGGGGAGUACGA-CCGCAAGGU-UGAAACUCAAAGGAAUUGACGG GGACCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGAAGAA-CCUU- A-CCA-AAUCUUGACAUCCUU-U--G-A-CAAC-UCUA--GAGA---UAGA-G-CCUUCC ----CC-UUCG-GG--GGGGCAAAG-UGACAGG-UGGUGCAUGGUUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UAAGC-UUAGUUGCC-A UCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-AA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUAAGUUGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAAUCAUC-AUGCCCCUU-AUGAUUUGGGCUACACACGUGCUAC AAUG-GACAAUACAAAGGGC---------------------------------------- ----------------------A-GCGAAACCGCGAGGUCAAGCAAA-UCCC--A-UAAA GUUGUUCUCAGUUCGGAUUGUAGUCUGCAACUCGACUACAUG-AAGCUGGAAUCGCUAGU AAUCGUAG-AUCAGC-AUGCUACGGUGAAUACGUUCCCGGGUCUUGUACACACCGCCCGU CACACCACGAGAG-UUUGUAAC-ACCCGAAGCCGGUGGAGUAACCU-------------- ----U-UU-----------------------AGGAGCUAG----------CCGUCG-AAG GUGGGACAAAUGAUUGGGGUGAAGUCGUAACAAGGUAGCCGUAUCGGAAGGUGCGGCUGG AUCACCUCCUUUCU-------- >Streptococcus_pneumoniae ---------------------GUUUGAUCCUG-GCUCAGGACGA-ACGCUGGCGGC-G-U GC-CUAAUACAUGCAAGUAGAACGCUG-AAG---------GAGGAG------CU---U-G -------CUUCUC------------U-GG--AU-GAG-UUGCG-AACGGGUGAGUAACGC GUAGGUAAC-CUGCCUGGUAG---------------------CGGGGG-AUAACUA--U- U-GGAAA-CGAUAGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UAAGA-GUGGAUG-UU----------------------------------- ------------------------------------------------------------ ----G-CA-U---GAC-AU-UUGCUU-AAAA-GGUGC--------------------A-- C-U-U-----------------GCAUCACUACCAGAUGGACCUGCG-UUGUAUUA-GCUA --GUUGGUGGGGUAACGGCUCA-CCAAGGCGACGAUACAU-AGCCGACCUGAGAGGGU-G AUCGGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUAGGGAA UCUUCGGCAAUGGAC-GGA----AGUCUGACCGAGCAACGCCGCGU--GAGUGAAGAAGG UU--UU-CG--GAUC-GU-AAAG-CUCUGUUGUAAGAGAAGAACGAGUGUGAGA-GUGGA A-A-GUUCAC-ACUGUGACGGUAUCUUACC-AGAAAGGGAC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGUCCCGAGCGUUGUCCGGAUUUAUUGGGCGUAAAGCGAGC GCAGGCGGUUAGA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUGAAGUUAAAGGCUGUGGCUUAACC- --------------------------------AUAG-UA-GG-CUUUGGAAACUGUUU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AACUU--GAGUGCAAGA G-GGGAGAGUGGAA-UUCCAUGUGUAGCGGUGAAAUGCGUAGAUAUAUGGAGGAACACCG GUGGCGAAAGCGGCUCUCUGGCUUGUAACUGACGCUGAGGCUCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCUGUAAACGAUGA-GUGCUAGGUGUUAGACC C----------------------------------------------------------- ---UUUCC---------------------------------------------------- ---------------------GGGGUUUAGU-GCCGUAGCUAACGC-AUUAAGCA----- -------CUCC-GCCUGGGGAGUACGA-CCGCAAGGU-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGAAGAA-CCUU- A-CCA-GGUCUUGACAUCCCUCU--G-A-CCGC-UCUA--GAGA---UAGA-G-UUUU-- ----CC-UUCG-GG----ACAGAGG-UGACAGG-UGGUGCAUGGUUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCC-UAUUG-UUAGUUGCC-A UCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-CA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUAGCGAGACU-GCCG-G----UAA-UAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAAUCAUC-AUGCCCCUU-AUGACCUGGGCUACACACGUGCUAC AAUG-GCUGGUACAACGAGU---------------------------------------- ----------------------C-GCAAGCCGGUGACGGCAAGCUAA-UCUC--U-UAAA GCCAGUCUCAGUUCGGAUUGUAGGCUGCAACUCGCCUACAUG-AAGUCGGAAUCGCUAGU AAUCGCGG-AUCAGC-ACGCCGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCACGAGAG-UUUGUAAC-ACCCGAAGUCGGUGAGGUAACC--------------- ----G-UA-A----------------------GGAGCCAG----------CCGCCU-AAG GUGGGAUAGAUGAUUGGGGUGAAGUCGUAACAAGGUAGCCGUAUCGGAAGGUGCGGCUGG AUCACCUCCUUUCU-------- >Streptomyces_coelicolor ---------CAUUCACGGAGAGUUUGAUCCUG-GCUCAGGACGA-ACGCUGGCGGC-G-U GC-UUAACACAUGCAAGUCGAACGAUG-AAC---------CA---C------UU---C-G -------G---UG------------G-GG--AU-UAG-UGGCG-AACGGGUGAGUAACAC GUGGGCAAU-CUGCCCUUCAC---------------------UCUGGG-ACAAGCC--C- U-GGAAA-CGGGGUCUAAUACCGGA----------------------------------- ------------------------------------------------------------ ---------UACUGACCCUCGC-AG----------------------------------- ------------------------------------------------------------ ----G-CA-U---CUG-CG-AGGGUC-GAAA-GC-----------------------U-- C-C-G--------------------GCGGUGAAGGAUGAGCCCGCG-GCCUAUCA-GCUU --GUUGGUGAGGUAAUGGCUCA-CCAAGGCGACGACGGGU-AGCCGGCCUGAGAGGGC-G ACCGGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGCACAAUGGGC-GAA----AGCCUGAUGCAGCGACGCCGCGU--GAGGGAUGACGG CC--UU-CG--GGUU-GU-AAAC-CUCUUUCAGCAGGGAAGAA-GC---------GA--A A-----------G--UGACGGUACCUGCAG-AAGAAGCGCC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGGCGCAAGCGUUGUCCGGAAUUAUUGGGCGUAAAGAGCUC GUAGGCGGCUUGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CACGUCGGUUGUGAAAGCCCGGGGCUUAACC- --------------------------------CCGG-GU-CUGCAGUCGAUACGGGCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GAGUUCGGUA G-GGGAGAUCGGAA-UUCCUGGUGUAGCGGUGAAAUGCGCAGAUAUCAGGAGGAACACCG GUGGCGAAGGCGGAUCUCUGGGCCGAUACUGACGCUGAGGAGCGAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGGUGG-GCACUAGGUGUGGGCAA C----------------------------------------------------------- --AUUCCAC--------------------------------------------------- ----------------------GUUGUCCGU-GCCGCAGCUAACGC-AUUAAGUG----- -------CCCC-GCCUGGGGAGUACGG-CCGCAAGGC-UAAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGCGGAGCAUGUGGCUUAAUUCGACGCAACGCGAAGAA-CCUU- A-CCA-AGGCUUGACAUACACCG--G-A-AAGC-AUCA--GAGA---UGGU-G-CCC--- ----CC-CUUGUGG------UCGGU-GUACAGG-UGGUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UGUCC-CGUGUUGCC-A GCAA-------------------------------------------------------- ------------------------------------------------------------ ------------GCCCU-UC--GGGGU--------------------------------- ------------------------------------------------------------ ------------------------------------------------GU---------- --U-G---------GGGACUCACGGGAGACC-GCCG-G----GGU-CAACU-CG-GAGGA AGGUGGGGACGACGUCAAGUCAUC-AUGCCCCUU-AUGUCUUGGGCUGCACACGUGCUAC AAUG-GCCGGUACAAUGAGC---------------------------------------- ----------------------U-GCGAUACCGCAAGGUGGAGCGAA-UCUC--A-AAAA GCCGGUCUCAGUUCGGAUUGGGGUCUGCAACUCGACCCCAUG-AAGUCGGAGUCGCUAGU AAUCGCAG-AUCAGCAUUGCUGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACGUCACGAAAG-UCGGUAAC-ACCCGAAGCCGGUGGCCCAACCC-------------- ----C-UU-GU--------------------GGGAGGGAG----------CUGUCG-AAG GUGGGACUGGCGAUUGGGACGAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGCGGCUGG AUCACCUCCUUUCU-------- >Symbiobacterium_thermophilum ---------UUUCCACGGAGAGUUUGAUCCUG-GCUCAGGACGA-ACGCUGGCGGC-G-U GC-CUAAGACAUGCAAGUCGAGCGGGG-UUU---------CAGGGC------UU---C-G -------GCCCUG------------A-GA--CC-CAG-CGGCG-GACGGGUGAGUAACAC GUGGAUAAC-CUGCCCUCUGC---------------------UCUGGG-AUAACAG--G- C-CGAAA-GGCCUGCUAAUACCGGA----------------------------------- ------------------------------------------------------------ ---------UAAGCUCACGGAC-CC----------------------------------- ------------------------------------------------------------ ----G-CA-U---GGG-UU-UGGGAG-AAAA-GGCGCUGGA----------------G-U C-A-G---------------UGGCGCUGGCAGAGGAGGGGUCCGCG-GCCCAUUA-GCUG --GUUGGCGGGGUAACGGCCCA-CCAAGGCGACGAUGGGU-AGCCGGCCUGAGAGGGC-G ACCGGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUCGGGAA UUUUGCACAAUGGCC-GAA----AGGCUGAUGCAGCAACGCCGCGU--GAGCGAAGAAGG CC--UU-CG--GGUU-GU-AAAG-CUCUGUUGCCUGCGAAGAA-GGGCCCUGUCAGGAAA ---UGGGCGGGGUU-UGACGGUAGCAGGCG-AGGAAGCCCC-GGCAA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGGGGCGAGCGUUGUCCGGAAUUACUGGGCGUAAAGGGCGU GUAGGCGGCCUGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCAGGGGUGAAAGACCGGGGCUCAACC- --------------------------------CCGG-GG-GUGCCUCUGAAACUGGCG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUU--GAGUGCUCUA G-AGGGCAGUGGAA-UUCCCGGUGUAGCAGUGAAAUGCGUAGAGAUCGGGAGGAACACCA GUGGCGAAGGCGGCUGCCUGGGGAGUCACUGACGCUGAGGCGCGAAAGCUAGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCUAGUCGUAAACGAUGA-GCGCUAUGUGUGAGGGG U----------------------------------------------------------- --AUCGACC--------------------------------------------------- -----------------------CCCCUCGU-GCAGUAGCUAACGC-AUUAAGCG----- -------CUCC-GCCUGGGGAGUACGG-CCGCAAGGU-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCAGCGGAGCAUGUGGUUUAAUUCGAAGCAACGCGUAGAA-CCUU- A-CCA-GGGCUUGACAUCCAC-C--G-A-AUCC-UGCA--GAGA---UGCG-G-GAGUGC CU--CUCUAAUGAG-AGGAACGGUG-AGACAGG-UGGUGCAUGGUUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCC-UGUCG-CAUGUUGCC-A GCGG-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-AA--A------------------------------------- ------------------------------------------------------------ ------------------------------------------------GC---------- --C-G---------GGCACUCAUGCGAGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAAUCAUC-AUGCCCCUU-AUGUCCUGGGCUACACACGUGCUAC AAUG-GCCGUCACAGAGCGA---------------------------------------- ----------------------G-CCGAACCUGCGAGGGGGAGGGAA-UCGC--A--AAA GGCGGUCUCAGUUCGGAUCGCAGGCUGCAACUCGCCUGCGUG-AAGUCGGAGUUGCUAGU AAUCGCGG-AUCAGC-AUGCCGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-CUGGCAAC-ACCCGAAGUCGGUGAGCUAACCC-------------- ----G-CA-A---------------------GGGAGGCAG----------CCGCCG-AAG GUGGGGCCGGUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAUCGGAAGGUGCGGCUGG AUCACCUCCUUUCUAAG----- >Synechococcus_sp. ------------------AGAGUUUGAUCCUG-GCUCAGGAUGA-ACGCUGGCGGC-G-U GC-UUAACACAUGCAAGUCGAACGGAC------------------C------UU---U-U -------CG----------------G-AG--GU-UAG-UGGCG-GACGGGUGAGUAACGC GUGAGG-AU-CUGCCUAUAGG---------------------AUGGGG-ACAACAG--G- G-AGAAA-UUCCUGCUAACACCCGA----------------------------------- ------------------------------------------------------------ ---------UGUG-CC-------------------------------------------- ------------------------------------------------------------ ----G-AG-A-------------GGU-GAAA-UA-----------------------U-- U-A-A--------------------UAGCCUGUAGAUGAGCUCGCG-UCUGAUUA-GCUA --GUUGGUGGGGUAAAGGCUUA-CCAAGGCGACGAUCAGU-AGCUGGUCUGAGAGGAC-G AUCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UUUUCCGCAAUGGGC-GCA----AGCCUGACGGAGCAACGCCGCGU--GAGGGAGGAAGG CC--UG-UG--GGUU-GU-AAAC-CUCUUUUCUCAGGGAAGA-------------AGAUU C--------------UGACGGUACCUGAGG-AAUCAGCAUC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAGACGGAGGAUGCAAGCGUUAUCCGGAAUUAUUGGGCGUAAAGCGUCC GUAGGCGGUUUAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------AAAGUCAGUUGUUAAAGCCCACAGCUCAACU- --------------------------------GUGG-AU-GGGCAAUUGAAACUACUA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUA--GAGAGUGGUA G-GGGUAGAGGGAA-UUCCUAGUGUAGCGGUGAAAUGCGUAGAUAUUAGGAAGAACACCA GUGGCGAAGGCGCUCUACUGGGCCAUUACUGACGCUGAUGGACGAAAGCUAGGGGAGCGA AAGGGAUUAGAUACCCCU-GUAGUCCUAGCUGUAAACGAUGG-ACACUAGGUGUUGCGCG U----------------------------------------------------------- --AUCGACC--------------------------------------------------- -----------------------CGUGCAGU-AUCGAAGCAAACGC-GUUAAGUG----- -------UCCC-GCCUGGGGAGUACGC-ACGCAAGUG-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGUAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCA-GGGAUUGACAUCCUA-C--G-A-AGAC-UUUU--GAAA---GAGA-G-UUGUG- ----CC-UUCG-GG----AACGUAG-AGACAGG-UGGUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-CGUCC-UUAGUUGCC-A UCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-AA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUUUAAGGAGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCAUC-AUGCCCCUU-ACAUCCUGGGCUACACACGUACUAC AAUG-CAACGGACAAAGGGC---------------------------------------- ----------------------A-GCCAACUAGCGAUAGUGAGCUAA-UCCC--A-UAAA CCGUUGCUCAGUUCAGAUUGCAGGCUGCAACUCGCCUGCAUG-AAGGCGGAAUCGCUAGU AAUCGCAG-GUCAGC-AUACUGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGAAG-UUGGCCAC-GCCCGAAGUCGUUACCCCAACC--------------- ----C-UU-GU---------------------GGAGGGGG----------ACGCCG-AAG GCAGGGCUGAUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGUGGCUG- ---------------------- >Synechocystis_sp. -----------ACAAUGGAGAGUUUGAUCCUG-GCUCAGGAUGA-ACGCUGGCGGU-A-U GC-CUAACACAUGCAAGUCGAACGGAG----------------UUC------UU---C-G -------GAA---------------------CU-UAG-UGGCG-GACGGGUGAGUAACAC GUGAGA-AC-CUACCUUCAGA---------------------AUGGGG-ACAACAG--U- U-GGAAA-CGACUGCUAAUACCCAA----------------------------------- ------------------------------------------------------------ ---------UGUG-CC-------------------------------------------- ------------------------------------------------------------ ----G-AA-A-------------GGU-GAAA-GA-----------------------U-- U-U-A--------------------UCGUCUGAAGAUGGGCUCGCG-UCUGAUUA-GCUA --GAUGGUGGGGUAAGAGCCUA-CCAUGGCAACGAUCAGU-AGCUGGUCUGAGAGGAU-G AGCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UUUUCCGCAAUGGGC-GAA----AGCCUGACGGAGCAAUACCGCGU--GAGGGAGGAAGG UC--CU-UG--GAUU-GU-AAAC-CUCUUUUAUCAGGGAAGA-------------AGU-U C--------------UGACGGUACCUGAUG-AAUAAGCAUC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGAUGCAAGCGUUAUCCGGAAUUAUUGGGCGUAAAGCGUCC GUAGGUGGUUAUG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUCUGCCGUUAAAGAAUGGAGCUUAACU- --------------------------------CCAU-AG-GAGCGGUGGAAACUGCAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUA--GAGUACAGUA G-GGGUAGCAGGAA-UUCCCAGUGUAGCGGUGAAAUGCGUAGAUAUUGGGAAGAACAUCG GUGGCGAAAGCGUGCUACUGGGCUGAAACUGACACUGAGGGACGAAAGCUAGGGUAGCGA AAGGGAUUAGAUACCCCU-GUAGUCCUAGCCGUAAACGAUGG-AUACUAGGCGUGGCUUG U----------------------------------------------------------- --AUCGACC--------------------------------------------------- -----------------------CGAGCCGU-GCCGAAGCUAACGC-GUUAAGUA----- -------UCCC-GCCUGGGGAGUACGC-ACGCAAGUG-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGUAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCA-AGGCUUGACAUCCCU-G--G-A-AUCC-UGCG--GAAA---CGUG-G-GAGUG- ----CC-UUAG-GG----AGCCAGG-AGACAGG-UGGUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-CGUUU-UUAGUUGCC-A UCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-AA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUAGAGAGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCAUC-AUGCCCCUU-ACGCCUUGGGCUACACACGUACUAC AAUG-GUCGGGACAACGGGC---------------------------------------- ----------------------A-GCGAGCUCGCGAGAGUAAGCGAA-UCCC--AUCAAA CCCGGCCUCAGUUCAGAUUGCAGGCUGCAACUCGCCUGCAUG-AAGGAGGAAUCGCUAGU AAUCGCAG-GUCAGA-AUACUGCGGUGAAUUCGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-CUGGUCAC-GCCCGAAGUCGUUACUCUAACC--------------- ----U-UA-G----------------------GGAGGAGG----------GCGCCG-AAG GCAGGGCUAGUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGUGGCUGG AUCACCUCCUUU---------- >Thermoanaerobacter_tengcongensis -----------------GAGAGUUUGAUCCUG-GCUCAGGACGA-ACGCUGGCGGC-G-U GC-CUAACACAUGCAAGUCGAGCGGGC-CUG-------UCAAGGCG------UU-----A -------UGUUUUGG----------C-AG--GUUAAG-CGGCG-GACGGGUGAGUAACGC GUGAGCAAC-CUACCCUUGAG---------------------ACAGGG-AUAACCC--U- G-GGAAA-CCGGGGCUAAUACCUGA----------------------------------- ------------------------------------------------------------ ---------UAUACUCUAUU-A-GG----------------------------------- ------------------------------------------------------------ ----G-CA-U---CCU-G--AUGGAG-GAAAGGGC----------------------G-- G-G-AA------------------GCCGCUCAAGGAUGGGCUCGCG-UCCCAUCA-GCUA --GUUGGUGAGGUAACGGCUCA-CCAAGGCUACGACGGGU-AGCCGGCCUGAGAGGGU-G GUCGGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UCUUCCGCAAUGGGC-GAA----AGCCUGACGGAGCGACGCCGCGU--GAGCGAAUAAGG CC--UU-CG--GGUC-GU-AAAG-CUCGAUAGUGUGGGAAGA-------------AGG-G A--------------UGACGGUACCACACG-A--AAGCCCC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAGACGUAGGGGGCGAGCGUUGUCCGGAGUUACUGGGCGUAAAGGGCGC GUAGGCGGUUUAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUCAGGUGUAAAAGGCCACGGCUCAACC- --------------------------------GUGG-AU-AUGCAUCUGAAACUGCUG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AGCUA--GAGGGCAGGA G-AGGGGAGUGGAA-UUCCCGGUGUAGCGGUGAAAUGCGUAGAUAUCGGGAGGAAUACCA GUGGCGAAGGCGACUCCCUGGACUGGCCCUGACGCUGAGGCGCGAGAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCUGUAAACGAUGG-GUGCUAGGUGUGGGGAG C----------------------------------------------------------- ----GGAA---------------------------------------------------- ----------------------GCUUUCCGU-GCCGUAGGAAACCC-AAUAAGCA----- -------CCCC-GCCUGGGGAGUACGG-CCGCAAGGC-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGAAGAA-CCUU- A-CCA-GGGCUUGACAUGCAGGU--G-G-UAGCGACCC--GAAA---GGGAAG-CGACCC UA--CCGGUA-AGG-UAGGGAGCCU-GCACAGG-UGGUGCAUGGUUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCC-UGCCU-CUAGUUGCC-A GCGG-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-GA--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------GC---------- --C-G---------GGCACUCUAGAGGGACU-GCCG-U----CGA-UAAGA-CG-GAGGA AGGUGGGGAUGACGUCAAAUCAUC-AUGCCCUAU-AUGCCCUGGGCCACACACGUGCUAC AAUG-GCCGGUACAGAGGGA---------------------------------------- ----------------------A-GCGAAGGAGUGAUCUGGAGCGAA-UCCC--A-AAAA GCCGGUCUCAGUUCGGAUUGCAGGCUGCAACUCGCCUGCAUG-AAGGCGGAAUCGCUAGU AAUCGCGG-AUCAGC-AUGCCGCGGUGAAUGCGUUCCCGGGCCUUGUACACACCGCCCGU CACACCACGAGAG-UCUGCAAC-ACCCGAAGCCGGUGGCCCAACCC-------------- ----G-AAGA---------------------GGGAGGGAG----------CCGUCG-AAG GUGGGGCAGAUGAUUGGGGUGAAGUCGUAACAAGGUAGCCGUACGGGAACGUGCGGCUGG AUCACCUCCUU----------- >Thermosynechococcus_elongatus -----------AAAAUGGAGAGUUUGAUCCUG-GCUCAGGAUGA-ACGCUGGCGGU-C-U GC-UUAACACAUGCAAGUCGAACGAGC-----------------AC------UU---C-G -------GU----------------------GC-UAG-UGGCG-GACGGGUGAGUAACAC GUGAGA-AU-CUACCCUCAGG---------------------AGGGGG-AUAACGG--C- U-GGAAA-CGGCCGCUAAUACCCCA----------------------------------- ------------------------------------------------------------ ---------UAUG-CC-------------------------------------------- ------------------------------------------------------------ ----G-CA-A-------------GGU-GAAAUCUU----------------------U-- U-U----------------------UGGCCUGGGGAUGAGCUCGCG-GUGGAUUA-GCUA --GUUGGUGGGGUAAUGGCCUA-CCAAGGCGACGAUCCAU-AGCUGGUCUGAGAGGAU-G AUCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UUUUCCGCAAUGGGC-GAA----AGCCUGACGGAGCAAGACCGCGU--GAGGGAUGAAGG CC--UU-UG--GGUU-GU-AAAC-CUCUUUUCUCAGGGAAGA-------------ACACA A--------------UGACGGUACCUGAGG-AAUAAGCCUC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAGACGGAGGAGGCAAGCGUUAUCCGGAAUUAUUGGGCGUAAAGCGUCC GCAGGUGGCUUUC----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUCUGCCGUCAAAGCCCGAGGCUUAACC- --------------------------------UCGG-AU-CGGCGGUGGAAACUGGAU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------CGCUA--GAGUGCGUCA G-GGGUAGGGGGAA-UUCCCGGUGUAGCGGUGAAAUGCGUAGAUAUCGGGAAGAACACCA GUGACGAAAGUGCCCUACUGGGACGUUACUGACACUCAUGGACGAAAGCUAGGGGAGCGA AAGGGAUUAGAUACCCCU-GUAGUCCUAGCCGUAAACGAUGG-ACACUAGGUGUUGCUGG U----------------------------------------------------------- ---AUCCAC--------------------------------------------------- ----------------------UCCAGCAGU-GCCGUAGCCAACGC-GUUAAGUG----- -------UCCC-GCCUGGGGAGUACGC-ACGCAAGUG-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGUAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCA-GGGCUUGACAUGUCG-C--G-A-AUCC-CGCG--GAAA---CGUG-G-GAGUG- ----CC-UUCG-GG----AACGCGA-ACACAGG-UGGUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-CGUCC-UUAGUUGCC-A GCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-CA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUCUAGGGAGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCAUC-AUGCCCCUU-ACGUCCUGGGCUACACACGUACUAC AAUG-CUGUGGACAAAGAGU---------------------------------------- ----------------------U-GCCAACCCGCGAGGGCGAGCUAA-UCUC--U-UAAA CCACGGCUCAGUUCAGAUUGCAGGCUGCAACUCGCCUGCAUG-AAGGCGGAAUCGCUAGU AAUCGCAG-GUCAGC-AUACUGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UUGGCCAU-GCCCGAAGUCGUUACUCUAACCC-------------- ----G-CA-A---------------------GGGAGGGGG----------ACGCCU-AAG GCAGGGCUGAUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGUGGCUGG AUCACCUCCUUUU--------- >Thermotoga_maritima -----------UAUAUGGAGGGUUUGAUCCUG-GCUCAGGGUGA-ACGCUGGCGGC-G-U GC-CUAACACAUGCAAGUCGAGCGGGGGAAA-C-------U--CCC------UU---C-G -------GGGAGG---------A--G-UA--CC-CAG-CGGCG-GACGGGUGAGUAACAC GUGGGUAAC-CUGCCCUCCGG---------------------AGGGGG-AUAACCA--G- G-GGAAA-CCCUGGUUAAUACCCCA----------------------------------- ------------------------------------------------------------ ---------UACGCUCCAUC-A-AC----------------------------------- ------------------------------------------------------------ ----G-CA-A---GUU--G-GUGGAG-GAAA-GGGGC--------------------G-- U-U-U-----------------GCCCCGCCGGAGGAGGGGCCCGCG-GCCCAUCA-GGUA --GUUGGUGGGGUAACGGCCCA-CCAAGCCGACGACGGGU-AGCCGGCCUGAGAGGGU-G GUCGGCCACAGGGGCACUGAGACACGGGCCCCACU-CUACGG-GAGGCAGCAGUGGGGAA UCUUGGACAAUGGGG-GAA----ACCCUGAUCCAGCGACGCCGCGU--GCGGGACGAAG- CC--UU-CG--GGGU-GU-AAAC-CGCUGUGGCGGGGGAAGAAUAAGGUAGGGA-GGA-A A-U-GCCCUA-CCGAUGACGGUACCCCGCU-AGAAAGCCCC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGGGGCAAGCGUUACCCGGAUUUACUGGGCGUAAAGGGGGC GUAGGCGGCCUGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UGUGUCGGAUGUGAAAUCCCACGGCUCAACC- --------------------------------GUGG-GG-CUGCAUCCGAAACUACCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUU--GGGGGCGGUA G-AGGGAGACGGAA-CUGCCGGUGUAGGGGUGAAAUCCGUAGAUAUCGGCAGGAACGCCG GUGGGGAAGCCGGUCUCCUGGGCCGACCCCGACGCUGAGGCCCGAAAGCCAGGGGAGCAA ACCGGAUUAGAUACCCGG-GUAGUCCUGGCUGUAAACGAUGC-CCACUAGGUGUGGGGGG G----------------------------------------------------------- ----UAA----------------------------------------------------- ----------------------UCCCUCCGU-GCUGAAGCUAACGC-GUUAAGUG----- -------GGCC-GCCUGGGGAGUACGC-CCGCAAGGG-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCGUGUGGUUUAAUUGGAUGCUAAGCCAAGAA-CCUU- A-CCA-GGGCUUGACAUGCCGGU--G-GUACCU-CCCC--GAAA---GGGGUA-GGGACC CAGUCC-UUCG-GGACUGGGAGCCG-GCACAGG-UGGUGCACGGCCGUCGUCAGCUCGUG CC-GUGAGGUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCC-UGCCC-CUAGUUGCC-A GCGG-------------------------------------------------------- ------------------------------------------------------------ ----------------U-UC--GG------------------------------------ ------------------------------------------------------------ -------------------------------------------------C---------- --C-G---------GGCACUCUAGGGGGACU-GCCG-G----CGA-CGAGC-CG-GAGGA AGGAGGGGAUGACGUCAGGUACUC-GUGCCCCUU-AUGCCCUGGGCGACACACGCGCUAC AAUG-GGCGGUACAAUGGGU---------------------------------------- ----------------------U-GCGACCCCGCGAGGGGGAGCCAA-UCCC----CAAA GCCGCCCUCAGUUCGGAUCGCAGGCUGCAACCCGCCUGCGUG-AAGCCGGAAUCGCUAGU AAUCGCGG-AUCAGCCAUGCCGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACGCCACCCGAG-UCGGGGGC-UCCCGAAGACACCUACCCCAACCC------------- ----G-AA-A--------------------GGGAGGGGGG----------GUGUCG-AGG GAGAACCUGGCGAGGGGGGCGAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGCGGCUGG AUCACCUCCUUUC--------- >Thermus_thermophilus -----------UUGUUGGAGAGUUUGAUCCUG-GCUCAGGGUGA-ACGCUGGCGGC-G-U GC-CUAAGACAUGCAAGUCGUGCGGGC-CGC----------GGGGU------UU---U-- -------ACUCC-------------G-UG--GU-CAG-CGGCG-GACGGGUGAGUAACGC GUGGGUGAC-CUACCCGGAAG---------------------AGGGGG-ACAACCC--G- G-GGAAA-CUCGGGCUAAUCCCCCA----------------------------------- ------------------------------------------------------------ ---------UGUGGACCCG--C-CC----------------------------------- ------------------------------------------------------------ ----C-UU-G-------GGGUGUGUC-CAAA-GGGC---------------------U-- U-U--------------------GCCCGCUUCCGGAUGGGCCCGCG-UCCCAUCA-GCUA --GUUGGUGGGGUAAUGGCCCA-CCAAGGCGACGACGGGU-AGCCGGUCUGAGAGGAU-G GCCGGCCACAGGGGCACUGAGACACGGGCCCCACUCCUACGG-GAGGCAGCAGUUAGGAA UCUUCCGCAAUGGGC-GCA----AGCCUGACGGAGCGACGCCGCUU--GGAGGAAGAAGC CC--UU-CG--GGGU-GU-AAAC-UCCUGAA-CCCGGGACGAA-ACCCCC-----GAC-G A-------GG-GGACUGACGGUACCGGGGU-AAU-AGCGCC-GGCCA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGGCGCGAGCGUUACCCGGAUUCACUGGGCGUAAAGGGCGU GUAGGCGGCCUGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGCGUCCCAUGUGAAAGACCACGGCUCAACC- --------------------------------GUGG-GG-GAGCGUGGGAUACGCUCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GACGGUGGGA G-AGGGUGGUGGAA-UUCCCGGAGUAGCGGUGAAAUGCGCAGAUACCGGGAGGAACGCCG AUGGCGAAGGCAGCCACCUGGUCCACCCGUGACGCUGAGGCGCGAAAGCGUGGGGAGCAA ACCGGAUUAGAUACCCGG-GUAGUCCACGCCCUAAACGAUGC-GCGCUAGGUCUCUGGG- ------------------------------------------------------------ ----UCU----------------------------------------------------- ------------------------CCUGGGG-GCCGAAGCUAACGC-GUUAAGCG----- -------CGCC-GCCUGGGGAGUACGG-CCGCAAGGC-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGAAGAA-CCUU- A-CCA-GGCCUUGACAUGCUAGG--G-A-ACCC-GGGU--GAAA---GCCU-G-GGGUGC C---CC-GCGA-GG--GGAGCCCUA-GCACAGG-UGCUGCAUGGCCGUCGUCAGCUCGUG CC-GUGAGGUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCC-CGCCG-UUAGUUGCC-A GCGG-------------------------------------------------------- ------------------------------------------------------------ ----------------U-UC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------------GC---------- --C-G---------GGCACUCUAACGGGACU-GCCC-G----CGA--AAGC-GG-GAGGA AGGAGGGGACGACGUCUGGUCAGC-AUGGCCCUU-ACGGCCUGGGCGACACACGUGCUAC AAUG-CCCACUACAAAGCGA---------------------------------------- ----------------------U-GCCACCCGGCAACGGGGAGCUAA-UCGC--A-AAAA GGUGGGCCCAGUUCGGAUUGGGGUCUGCAACCCGACCCCAUG-AAGCCGGAAUCGCUAGU AAUCGCGG-AUCAGCCAUGCCGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACGCCAUGGGAG-CGGGCUCU-ACCCGAAGUCGCCGGG-AG-CC--------------- ----U-AC-G----------------------GG---CAG----------GCGCCG-AGG GUAGGGCCCGUGACUGGGGCGAAGUCGUAACAAGGUAGCUGUACCGGAAGGUGCGGCUGG AUCACCUCCUUU---------- >Treponema_pallidum -----------UUGUUGGAGAGUUUGAUCCUG-GCUCAGAACGA--CGCUGGCGG----U GCGUUUUAGCAUGCAAGUCGAACGGCAAGGA----------AGCGA------AU---U-U -------UCGUU----------U--C-UC--UA-GAG-UGGCG-GACUGGUGAGUAACGC GUGGGUAAU-CUGCCUUUGAG---------------------AUGGGG-AUAGCCU--C- U-AGAAA-UAGGGGGUAAUACCGAA----------------------------------- ------------------------------------------------------------ ---------UACGCUCUUUUGG-AC----------------------------------- ------------------------------------------------------------ ----G-UA-G---UCU--U-UGAGAG-GAAA-GGGGC--------------------U-- G-C-G-----------------GCCUCGCUCAGAGAUGAGCCUGCG-ACCCAUUA-GCUU --GUUGGUGGGGUAAUGGCCUA-CCAAGGCGUCGAUGGGU-AUCCGACCUGAGAGGGU-G ACCGGACACACUGGGACUGAGAUACGGCCCAGACUCCUACGG-GAGGCAGCAGCUAAGAA UAUUCCGCAAUGGGC-GAA----AGCCUGACGGAGCGACACCGCGU--GGAUGAGGAAGG UC--GA-AA--GAUU-GU-AAAG-UUCUUUUGCCGACGAAGAAUGAGGACGGGA-GGG-A A-U-GCCCGU-UUGAUGACGGUAGUCGUGCGAAUAAGCCCC-GGCUA-AUU-ACGUGCCA GCAGCCGCGGUAACACGUAAGGGGCGAGCGUUGUUCGGAAUUAUUGGGCGUAAAGGGCAU GCAGGCGGACUGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGCCUGGUGUGAAAUCCCCGAGCUCAACU- --------------------------------UGGG-AA-CUGCACUGGGUACUGCUG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GUCUA--GAAUCACGGA G-GGGAAACCGGAA-UUCCAAGUGUAGGGGUGGAAUCUGUAGAUAUUUGGAAGAACACCG GUGGCGAAGGCGGGUUUCUGGCCGAUGAUUGACGCUGAGGUGCGAAGGUGUGGGGAGCGA ACAGGAUUAGAUACCCUG-GUAGUCCACACAGUAAACGAUGU-ACACUAGGUGUUGGGGC ------------------------------------------------------------ ----AUGA---------------------------------------------------- -----------------------GUCUCGGC-GCCGACGCGAACGC-AUUAAGUG----- -------UACC-GCCUGGGGAGUAUGC-UCGCAAGAG-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAUGAUACGCGAGGAA-CCUU- A-CCC-GGGUUUGACAUCAAGAG--G-A-GCGC-CGUA--GAAA---UGCG-G-UGGCG- ----UA-GCGA-UA----CGCCUCU-UGACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG CC-GUGAGGUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCC-UACUG-CCAGUUGCC-A GCAA-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-GG--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------GU---------- --U-G---------GGGACUCUGGCGGAACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCAUC-AUGGCCCUU-AUGUCCGGGGCUACACACGUGCUAC AAUG-GUUGCUACAGAGCGA---------------------------------------- ----------------------U-GCGAGGUUGUGAAGUGGAGCAAA-CCGC--A-AAAA GGCAAUCGUAGUCCGGAUUGAAGUCUGAAACUCGACUUCAUG-AAGUUGGAAUCGCUAGU AAUCGCAC-AUCAGC-AUGGUGCGGUGAAUGUGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUCCGAG-UUGGAGAU-ACCCGAAGUCACUAGCCUAACCC-------------- ----G-CA-A---------------------GGGAGGGCG----------GUGCCG-AAG GUAUGUUUGGUAAGGAGGGUGAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGCGGCUGG AUCACCUCCUUUCUAAGAGA-- >Tropheryma_whipplei ---------UUAUUAUGGAGAGUUUGAUCCUG-GCUCAGGACGA-ACGCUGGCGGC-G-U GC-UUAACACAUGCAAGUCGAACGGAA-AUC---------AGGGAG------CU---U-G -------CUCCCU------------G-UG--AU-UAG-UGGCG-AACGGGUGAGUAACAC GUGAGCAAC-CUGCCCCUAAC---------------------UUUGGG-AUAACUU--C- G-GGAAA-CCGGGGCUAAUACCAAA----------------------------------- ------------------------------------------------------------ ---------UACGA-CCCAUGA-GG----------------------------------- ------------------------------------------------------------ ----G-CA-U---CCUCUG-UGGGUG-GAAA-GA-----------------------A-- U-U----------------------UCGGUUGGGGAUGGGCUCGCG-GCCUAUCA-GCUU --GUUGGUGGGGUAACGGCCUA-CCAAGGCAUCGACGGGU-AGCCGGCCUGAGAGGGU-G AUCGGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGCACAAUGGGC-GCA----AGCCUGAUGCAGCAACGCCGCGU--GGGGGAAGAAGG CC--UU-CG--GGUU-GU-AAAC-CUCUUUUGGCAGGGAAGAA-GC---------GA--A A-----------G--UGACGGUACCUGCAG-AAAAAGCGCC-GGCUA-ACU-ACGUGCCA GCAGCCGCGGUAAUACGUAGGGCGCGAGCGUUGUCCGGAAUUAUUGGGCGUAAAGAGCUC GUAGGCGGUUUGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CACGUCUGCCGUGAAAAUCCGAGGCUCAACC- --------------------------------UCGG-AC-CUGCGGUGGGUACGGGCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GAGUGCGAUA G-GGGAGAGCGGAA-UUCCUGGUGUAGCGGUGAAAUGCGCAGAUAUCAGGAGGAACACCG AUGGCGAAGGCAGCUCUCUGGGUCGCUACUGACGCUGAGGAGCGAAAGCGUGGGGAGCGA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGUUGG-GCGCUAGACGUGGGGGU G----------------------------------------------------------- --GUUCCAC--------------------------------------------------- ----------------------CGCUUCCGU-GUCGCAGCUAACGC-AUUAAGCG----- -------CCCC-GCCUGGGGAGUACGG-CCGCAAGGC-UAAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGCGGAGCAUGCGGAUUAAUUCAAUGCAACGCGAAGAA-CCUU- A-CCA-AGGCUUGAUAUAUACCG--G-A-AAGG-CGUA--GAGA---UACG-C-CCC--- ----CC-GCAA-GG------UCGGU-AUACAGG-UGGUGCACGGUUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-CGUCC-UGUGUUGCC-A GCGC-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-AA--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------GG---------- --C-G---------GGGACUCACAGGAGACU-GCCG-G----GGU-CAACU-CG-GAGGA AGGUGGGGAUGACGUCAAAUCAUC-AUG-CCCUU-CGGUCUUGGGCUUCACGCGUGCUAC AAUG-GCUGGUACAGAGGGU---------------------------------------- ----------------------U-GCAAUAUCGCAAGGUGGAGCGAA-UCUC--A-AAAA GCCAGUCUCAGUUCGGAUUGGGGUCUGCAACUCGACCCCAUG-AAGUCGGAGUCGCUAGU AAUCGCAG-AUCAGCAAUGCUGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CAAGUCAUGAAAG-CUGGUAAC-ACCCGAAGCCGGUGACUUAACC--------------- ----U-UU-UU---------------------GGAGAGAG----------CCGUCG-AAG GUGGGAUUGGUGAUUGGGACUAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGCGGCUGG AUCACCUCCUUUCU-------- >Vibrio_cholerae ------------------AGAGUUUGAUCAUG-GCUCAGAUUGA-ACGCUGGCGGC-A-G GC-CUAACACAUGCAAGUCGAGCGGCAGCAC--------AGAGGAA------CU---U-G -------UUCCUUG--------G--G-UG--GC-GAG-CGGCG-GACGGGUGAGUAAUGC CUGGGA-AA-UUGCCCGGUAG---------------------AGGGGG-AUAACCA--U- U-GGAAA-CGAUGGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UAACC-UC------------------------------------------- ------------------------------------------------------------ ----G-CA-A-------------GAG-CAAA-GCAGGGGACC---------------U-- U-C-G--------------GGCCUUGCGCUACCGGAUAUGCCCAGG-UGGGAUUA-GCUA --GUUGGUGAGGUAAGGGCUCA-CCAAGGCGACGAUCCCU-AGCUGGUCUGAGAGGAU-G AUCAGCCACACUGGAACUGAGACACGGUCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGCACAAUGGGC-GCA----AGCCUGAUGCAGCCAUGCCGCGU--GUAUGAAGAAGG CC--UU-CG--GGUU-GU-AAAG-UACUUUCAGUAGGGAGGAA-GGUGGUUAAG-UUAAU A-C-CUUAAU-CAUUUGACGUUACCUACAG-AAGAAGCACC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGGUGCAAGCGUUAAUCGGAAUUACUGGGCGUAAAGCGCAU GCAGGUGGUUUGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCAGAUGUGAAAGCCCUGGGCUCAACC- --------------------------------UAGG-AA-UCGCAUUUGAAACUGACA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AGCUA--GAGUACUGUA G-AGGGGGGUAGAA-UUUCAGGUGUAGCGGUGAAAUGCGUAGAGAUCUGAAGGAAUACCG GUGGCGAAGGCGGCCCCCUGGACAGAUACUGACACUCAGAUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGU-CUACUUGGAGGUUGUGC C----------------------------------------------------------- ---CUAGA---------------------------------------------------- ----------------------GGUGUGGCU-UUCGGAGCUAACGC-GUUAAGUA----- -------GACCCGCCUGGGGAGUACGG-UCGCAAGAU-UAAAACUCAAAUGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCU-ACUCUUGACAUCCAG-A--G-A-AUCU-AGCG--GAGA---CGCU-G-GAGUG- ----CC-UUCG-GG----AGCUCUG-AGACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UU-GUGAAAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UAUCC-UUGUUUGCC-A GCAC-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-AA--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------GG---------- --U-G---------GGAACUCCAGGGAGACU-GCCG-G----UGA-UAAAC-CG-GAGGA AGGUGGGGACGACGUCAAGUCAUC-AUGGCCCUU-ACGAGUAGGGCUACACACGUGCUAC AAUG-GCGUAUACAGAGGGC---------------------------------------- ----------------------A-GCGAUACCGCGAGGUGGAGCGAA-UCUC--A-CAAA GUACGUCGUAGUCCGGAUUGGAGUCUGCAACUCGACUCCAUG-AAGUCGGAAUCGCUAGU AAUCGCAA-AUCAGA-AUGUUGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UGGGCUGC-AAAAGAAGCAGGUAGUUUAACC--------------- ----U-UC-G----------------------GGAGGACG----------CUUGCC-ACU UUGUGGUUCAUGACUGGGGUGAAGUCGUAACAAGGUAGCGCUAGGGGAACCUGGCGCUGG AUCACCUCCUU----------- >Wolbachia_endosymbiont GGUUAAAGUCUAAAUUUGAGAGUUUGAUCCUG-GCUCAGAAUGA-ACGCUGGCGGC-A-G GC-CUAACACAUGCAAGUUGAACGGAG-UUA-------UAUUAUAA------CG---A-G -------UUAUAGUA----------U-AA--CU-GAG-UAGCA-GACGGGUGAGUAAUGU AUAGGA-AU-CUACCUAGUAG---------------------UACGGA-AUAAUUG--U- U-GGAAA-CGGCAACUAAUACCGUA----------------------------------- ------------------------------------------------------------ ---------UACGC-CC------------------------------------------- ------------------------------------------------------------ ----U-AC-G-------------GGG-GAAA-GA-----------------------U-- U-U-A--------------------UUGCUAUUAGAUGAGCCUAUA-UUAGAUUA-GCUA --GUUGGUAGGGUAAUGGCCUA-CCAAGGCAGUAAUCUAU-AGCUGAUCUGAGAGGAU-G AUCAGCCACACUGGAACUGAGAUACGGUCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGGACAAUGGGC-GAA----AGCCUGAUCCAGCCAUGCCGCAU--GAGUGAAGAAGG CC--UU-UG--GGUU-GU-AAAG-CUCUUUCAGUGAGGAAGA-------------UA--- A--------------UGACGGUACUCACAG-AAGAAGUCCU-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGAGGGCUAGCGUUAUUCGGAAUUAUUGGGCGUAAAGGGCGC GUAGGCUGAUUAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUUAAAAGUGAAAUCCCAAAGCUUAACU- --------------------------------UUGG-AA-UUGCUUUUAAAACUGUUA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AUCUA--GAGGUUGAAA G-AGGAUAGAGGAA-UUCCUAGUGUAGAGGUGAUAUUCGUAAAUAUUAGGAGGAACACCA GUGGCGAAGGCGUCUAUCUGGUUCAAAUCUGACGCUGAGGCGCGAAGGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCUGUAAACGAUGA-AUGUUAAAUAUGGGAAG ------------------------------------------------------------ ---UUU-A---------------------------------------------------- -----------------------CUUUCUGU-AUUACAGCUAACGC-GUUAAACA----- -------UUCC-GCCUGGGGACUACGA-UCGCAAGAU-UAAAACUCAAAGGAAUUGACGG GGACCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAUGCAACGCGAAAAA-CCUU- A-CCA-CUCCUUGACAUGGGA-A--UUA-UUCCUAUUC--GAAG---GAAUAG-GG-UC- ----GG-UUCGGCC----GAAUUUC-ACACAGG-UGUUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGUAACCCU-CAUCC-UUAGUUACC-A UCAGG------------------------------------------------------- ------------------------------------------------------------ ------------U---A-AU--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------C---------- --U-G---------GGGACUUUAAGGAAACU-GCUA-G----UGA-UAAAC-UG-GAGGA AGGUGGGGAUGAUGUCAAGUCAUC-AUGGCCCUU-AUGGAGUGGGCUACACACGUGCUAC AAUG-GUGGCUACAAUGGGC---------------------------------------- ----------------------U-GCAAAGUCGCGAGGCCAAGCUAA-UCCC--U-UAAA AGCCAUCUCAGUUCGGAUUGUACUCUGCAACUCGAGUGCAUG-AAGUUGGAAUCGCUAGU AAUCGUGG-AUCAGC-AUGCCACGGUGAAUACGUUCUCGGGUCUUGUACACACUGCCCGU CACGCCAUGGGAA-UUGGUUUC-ACUCGAAGCUAAUGACCUAACC--------------- ----G-UA-A----------------------GGAGGGAG----------UUAUUU-AAA GUGGGAUCAGUGACUGGGGUGAAGUCGUAACAAGGUAGCAGUAGGGGAAUCUGCAGCUGG AUUACCUCCUUG---------- >Xanthomonas_axonopodis -----------UAAGUGAAGAGUUUGAUCCUG-GCUCAGAGUGA-ACGCUGGCGGC-A-G GC-CUAACACAUGCAAGUCGAACGGCAGCAC-------AGUAAGAG------CU---U-G -------CUCUUAUG-------G--G-UG--GC-GAG-UGGCG-GACGGGUGAGGAAUAC AUCGGA-AU-CUACUCUUUCG---------------------UGGGGG-AUAACGU--A- G-GGAAA-CUUACGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UACGA-CC------------------------------------------- ------------------------------------------------------------ ----U-AC-G-------------GGU-GAAA-GCGGAGGACC---------------U-- U-C-G--------------GGCUUCGCGCGGUUGAAUGAGCCGAUG-UCGGAUUA-GCUA --GUUGGCGGGGUAAAGGCCCA-CCAAGGCGACGAUCCGU-AGCUGGUCUGAGAGGAU-G AUCAGCCACACUGGAACUGAGACACGGUCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGGACAAUGGGC-GCA----AGCCUGAUCCAGCCAUGCCGCGU--GGGUGAAGAAGG CC--UU-CG--GGUU-GU-AAAG-CCCUUUUGUUGGGAAAGAA-AAGCAGUCGG-UUAAU A-C-CCGAUU-GUUCUGACGGUACCCAAAG-AAUAAGCACC-GGCUA-ACU-UCGUGCCA GCAGCCGCGGUAAUACGAAGGGUGCAAGCGUUACUCGGAAUUACUGGGCGUAAAGCGUGC GUAGGUGGUGGUU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUGUUGUGAAAGCCCUGGGCUCAACC- --------------------------------UGGG-AA-UUGCAGUGGAUACUGGGU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------CACUA--GAGUGUGGUA G-AGGGUAGCGGAA-UUCCCGGUGUAGCAGUGAAAUGCGUAGAGAUCGGGAGGAACAUCC GUGGCGAAGGCGGCUACCUGGACCAACACUGACACUGAGGCACGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCCUAAACGAUGC-GAACUGGAUGUUGGGUG C----------------------------------------------------------- ---AAUUUG--------------------------------------------------- ----------------------GCACGCAGU-AUCGAAGCUAACGC-GUUAAGUU----- -------CGCC-GCCUGGGGAGUACGG-UCGCAAGAC-UGAAACUCAAAGGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGUAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCU-GGUCUUGACAUCCAC-G--G-A-ACUU-UCCA--GAGA---UGGA-U-UGGUG- ----CC-UUCG-GG----AACCGUG-AGACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UGUCC-UUAGUUGCC-A GCAC-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-AA--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------GG---------- --U-G---------GGAACUCUAAGGAGACC-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCAUC-AUGGCCCUU-ACGACCAGGGCUACACACGUACUAC AAUG-GUAGGGACAGAGGGC---------------------------------------- ----------------------U-GCAAACCCGCGAGGGCAAGCCAA-UCCC--A-GAAA CCCUAUCUCAGUCCGGAUUGGAGUCUGCAACUCGACUCCAUG-AAGUCGGAAUCGCUAGU AAUCGCAG-AUCAGCAUUGCUGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UUUGUUGC-ACCAGAAGCAGGUAGCUUAACC--------------- ----U-UC-G----------------------GGAGGGCG----------CUUGCC-ACG GUGUGGCCGAUGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAUCGGAAGGUGCGGCUGG AUCACCUCCUUU---------- >Yersinia_pestis ------------AAUUGAAGAGUUUGAUCAUG-GCUCAGAUUGA-ACGCUGGCGGC-A-G GC-CUAACACAUGCAAGUCGAGCGGCAGCGG--------GAAGUAG------UU---U-A -------CUACUUU--------G--C-CG--GC-GAG-CGGCG-GACGGGUGAGUAAUGU CUGGGG-AU-CUGCCUGAUGG---------------------AGGGGG-AUAACUA--C- U-GGAAA-CGGUGGCUAAUACCGCA----------------------------------- ------------------------------------------------------------ ---------UGACC-UC------------------------------------------- ------------------------------------------------------------ ----G-CA-A-------------GAG-CAAA-GUGGGGGACC---------------U-- U-A-G--------------GGCCUCACGCCAUCGGAUGAACCCAGA-UGGGAUUA-GCUA --GUAGGUGGGGUAAUGGCUCA-CCUAGGCGACGAUCCCU-AGCUGGUCUGAGAGGAU-G ACCAGCCACACUGGAACUGAGACACGGUCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGCACAAUGGGC-GCA----AGCCUGAUGCAGCCAUGCCGCGU--GUGUGAAGAAGG CC--UU-CG--GGUU-GU-AAAG-CACUUUCAGCGAGGAGGAA-GGGGUUGAGU-UUAAU A-C-GCUCAA-UCAUUGACGUUACUCGCAG-AAGAAGCACC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGGUGCAAGCGUUAAUCGGAAUUACUGGGCGUAAAGCGCAC GCAGGCGGUUUGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCAGAUGUGAAAUCCCCGCGCUUAACG- --------------------------------UGGG-AA-CUGCAUUUGAAACUGGCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AGCUA--GAGUCUUGUA G-AGGGGGGUAGAA-UUCCAGGUGUAGCGGUGAAAUGCGUAGAGAUCUGGAGGAAUACCG GUGGCGAAGGCGGCCCCCUGGACAAAGACUGACGCUCAGGUGCGAAAGCGUGGGGAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCUGUAAACGAUGU-CGACUUGGAGGUUGUGC C----------------------------------------------------------- ---CUUGA---------------------------------------------------- ----------------------GGCGUGGCU-UCCGGAGCUAACGC-GUUAAGUC----- -------GACC-GCCUGGGGAGUACGG-CCGCAAGGU-UAAAACUCAAAUGAAUUGACGG GGGCCCGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAUGCAACGCGAAGAA-CCUU- A-CCU-ACUCUUGACAUCCAC-A--G-A-AUUU-GGCA--GAGA---UGCU-A-AAGUG- ----CC-UUCG-GG----AACUGUG-AGACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UU-GUGAAAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-UAUCC-UUUGUUGCC-A GCAC-------------------------------------------------------- ------------------------------------------------------------ ------------G---U-AA--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------GG---------- --U-G---------GGAACUCAAGGGAGACU-GCCG-G----UGA-CAAAC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCAUC-AUGGCCCUU-ACGAGUAGGGCUACACACGUGCUAC AAUG-GCAGAUACAAAGUGA---------------------------------------- ----------------------A-GCGAACUCGCGAGAGCCAGCGGA-CCAC--A-UAAA GUCUGUCGUAGUCCGGAUUGGAGUCUGCAACUCGACUCCAUG-AAGUCGGAAUCGCUAGU AAUCGUAG-AUCAGA-AUGCUACGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UGGGUUGC-AAAAGAAGUAGGUAGCUUAACC--------------- ----U-UC-G----------------------GGAGGGCG----------CUUACC-ACU UUGUGAUUCAUGACUGGGGUGAAGUCGUAACAAGGUAACCGUAGGGGAACCUGCGGUUGG AUCACCUCCU------------ >Zymomonas_mobilis ------------------AGAGUUUGAUUCUG-GCUCAGAACGA-ACGCUGGCGGC-A-U GC-UUAACACAUGCAAGUCGAACGAAG-----------------GC------UU---C-G -------GC----------------------CU-UAG-UGGCG-CACGGGUGCGUAACGC GUGGGA-AU-CUGCCUUCAGG---------------------UACGGA-AUAACUA--G- G-GGAAA-CUCGAGCUAAUACCGUA----------------------------------- ------------------------------------------------------------ ---------UGACA-UC------------------------------------------- ------------------------------------------------------------ ----G-AG-A-------------GAU-CAAA-GA-----------------------U-- U-U-A--------------------UCGCCUGAAGAUGAGCCCGCG-UUGGAUUA-GCUA --GUUGGUAGGGUAAAAGCUUA-CCAAGGCGACGAUCCAU-AGCUGGUCUGAGAGGAU-G AUCAGCCACACUGGGACUGAGACACGGCCCAGACUCCUACGG-GAGGCAGCAGUGGGGAA UAUUGGACAAUGGGG-GAA----ACCCUGAUCCAGCAAUGCCGCGU--GAGUGAAGAAGG CC--UU-AG--GGUU-GU-AAAG-CUCUUUUACCCGGGAUGA-------------UA--- A--------------UGACAGUACCGGGAG-AAUAAGCUCC-GGCUA-ACU-CCGUGCCA GCAGCCGCGGUAAUACGGAGGGAGCUAGCGUUGUUCGGAAUUACUGGGCGUAAAGCGUAC GUAGGCGGUUUAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCAGGGGUGAAAGCCCAGAGCUCAACU- --------------------------------CUGG-AA-CUGCCUUUGAGACUGUUA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUA--GAACAUAGAA G-AGGUAAGUGGAA-UUCCGAGUGUAGAGGUGAAAUUCGUAGAUAUUCGGAAGAACACCA GUGGCGAAGGCGACUUACUGGUCUAUAGUUGACGCUGAGGUACGAAAGCGUGGGUAGCAA ACAGGAUUAGAUACCCUG-GUAGUCCACGCCGUAAACGAUGA-UAACUAGCUGUCCGGGU A----------------------------------------------------------- ---CAUGG---------------------------------------------------- ----------------------UAUCUGGGU-GGCGGAGCUAACGC-AUUAAGUU----- -------AUCC-GCCUGGGGAGUACGG-UCGCAAGAU-UAAAACUCAAAGAAAUUGACGG GGGCCUGC-ACAA-GCGGUGGAGCAUGUGGUUUAAUUCGAAGCAACGCGCAGAA-CCUU- A-CCA-GCGUUUGACAUCCUG-A--UCG-CGGAAAGUG--GAGA---CACAUU-CUUUC- ----AG-UUCGGCU----GGAUCAG-AGACAGG-UGCUGCAUGGCUGUCGUCAGCUCGUG UC-GUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCU-CACCU-CUAGUUGCC-A UCAU-------------------------------------------------------- ------------------------------------------------------------ ----------------U-AA--G------------------------------------- ------------------------------------------------------------ -------------------------------------------------U---------- --U-G---------GGCACUUUAGAGGAACU-GCCG-G----UGA-UAAGC-CG-GAGGA AGGUGGGGAUGACGUCAAGUCCUC-AUGGCCCUU-ACGCGCUGGGCUACACACGUGCUAC AAUG-GCGGUGACAGAGGGC---------------------------------------- ----------------------C-GCAAGCCUGCAAAGGUUAGCUAA-UCUC--A--AAA AGCCGUCUCAGUUCGGAUUGUUCUCUGCAACUCGAGAGCAUG-AAGGCGGAAUCGCUAGU AAUCGCGG-AUCAGC-AUGCCGCGGUGAAUACGUUCCCAGGCCUUGUACACACCGCCCGU CACACCAUGGGAG-UUGGAUUC-ACCCGAAGGCGCUGCGCUAACCC-------------- ----G-CA-A---------------------GGGAGGCAG----------GCGACC-ACG GUGGGUUUAGCGACUGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCU--------------- >Aeropyrum_pernix ----------------ACUCCGGUUGAUCCUG-CCGGACCCGAC--CGCUAUCGGG-GUA GGGCUAAGCCAUGGGAGUCGAACGCCC-CGC---------------------CG---C-U -------------------------G-CG--GG-GCG-UGGCG-GACGGCUGAGUAACAC GUGGCUAAC-CUACCCUCGGG---------------------ACGGGG-AUAACCCCUC- G-GGAAA-CUGGGGCUAAUCCCCGA----------------------------------- ------------------------------------------------------------ ---------UA-GG-CGGGGGGUGCC---------------------------------- ------------------------------------------------------------ ---UG-GA-A-G-GGU-CC-UCCGCC-GAAAGGGGCCG--CGGG-----------GGG-- U-UAUCG----------CCCGCGGUCCGCCCGAGGAUGGGGCUGCG-GCCCAUCACGGUA --GUUGGCGGGGUAAUGGCCCG-CCAAGCCUACGACGGGU-AGGGGCCGUGAGAGCGG-G AGCCCCCAGAUGGGCACUGAGACAAGGGCCCAGGCCCUACGG-GGCGCACCAGGCGCGAA AACUCCGCAAUGCGG-GCA----ACCGUGACGGGGCUACCCCGAGU--GCCC------CC C---UU--G---GGG-------G-GGCUUUUCCCCGCUG----------------UAA-G U-A-------------------GGCGGGGG-AAUAAGCGGGGGGCAAGACU-GG-UGUCA GCCGCCGCGGUAAUACCAGCCCCGCGAGCGGUCGGGGUGCUUACUGGGCCUAAAGCGCCC GUAGCCGGCUCGA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUCCCCGCCUAAAGCCCCGGGCUCAACC- --------------------------------CGGG-GA-GUGGCGGGGAUACUGUCG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GGGGGCGGGA G-AGGCCGAGGGUA-CUCCCGGGGUAGGGGCGAAAUCCAUUAAUCCCGGGAGGACCACCA GUGGCGAAGGCGCUCGGCUGGAACGCGCCCAACGGUGAGGGGCGAAAGCCGGGGGAGCGA ACCGGAUUAGAUACCCGG-GUAGUCCCGGCUGUAAACGAUGC-GGGCUAGGUGUUGGGCG GGC--------------------------------------------------------- ---GUGCGA--------------------------------------------------- --------------------GCCCGCCCAGU-GCCGCAGGGAAGCC-GUUAAGCC----- -------CGCC-GCCUGGGGAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-GGGGUGGAGCCUGCGGCUUAAUUGGAGUCAACGCCGGGAA-CCUCC A-CCG-GGG-GC-GA-CAGCA-GGA-UGACGGC-CAGGCUGAAGG--CCUU-G-CCCGA- --------------------CGCG-CUGA-GGGGAGGUGCAUGGCCGUCGCCAGCUCGUG CC-GUGAGGUGUCCUGUUAAGUCAGGCAACGAGCGAGACCCC-CGCCC-CUAGUUGCC-A UCCCCGGG---------------------------------------------------- ------------------------------------------------------------ ----------------G-CG--A------------------------------------- ------------------------------------------------------------ ------------------------------------------C--CCG-G---------- --G-G---------GGCACACUAGGGGGACU-GCCG-C----CGC-UAAGG-CG-GAGGA AGGAGGGGGCAACGGCAGGUCAGC-AUGCCCCUA-AACCCCCGGGCCGCACGCGGGCUAC AAUG-GCGGGGACAGCGGGU---------------------------------------- ----------------------G-CCGACCCCGAAAGGGGGAGGCAA-UCCC--U-CAAA CCCCGCCUCAGUUGGGAUCGAGGGCUGCAACUCGCCCUCGUG-AACGUGGAAUCCCUAGU AACCGCGC-GUCAUC-AUCGCGCGGUGAAUACGUCCCUGCUCCUUGCACACACUGCCCGU CGCUCCACCCGAG-GGGGGAGG-GGGUGAGGCCCUC-UCC-------------------- ----G-CC-G-------------------------GGAGG----------GGGUCG-AAC CCCCUCCCCCCGAGGGGGGAGAACUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCC------------- >Archaeoglobus_fulgidus ----------------AUUCUGGUUGAUCCUG-CCAGAGGCCGC--UGCUAUCCGG-CUG GGACUAAGCCAUGCGAGUCAAGGGGCU-UGU----------AUCCC------UU---C-G -------GGGAU-------------G-CA--AG-CAC-CGGCG-GACGGCUCAGUAACAC GUGGACAAC-CUGCCCUCGGG---------------------UGGGGG-AUAACCC--C- G-GGAAA-CUGGGGCUAAUCCCCCA----------------------------------- ------------------------------------------------------------ ---------UA-GG-GGAUGGGUAC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GUC-CC-AUCUCC-GAAAGCG-----------------------C-- U-U-A-------------------GC-GCCCGAGGAUGGGUCUGCG-GCGGAUUA-GGUU --GUUGGUGGGGUAACGGCCCA-CCAAGCCGAAGAUCCGU-ACGGGCCAUGAGAGUGG-G AGCCCGGAGAUGGACCCUGAGACACGGGUCCAGGCCCUACGG-GGCGCAGCAGGCGCGAA ACCUCCGCAAUGCGG-GAA----ACCGCGACGGGGUCAGCCGGAGU--GCUC------GC GC--AU--C--GCGC-------G-GGCUGUCGGGGUGCC----------------UAA-A A-A-------------------GCACCCCACAGCAAGGGCCGGGCAAGGCC-GG-UGGCA GCCGCCGCGGUAAUACCGGCGGCCCGAGUGGCGGCCACUUUUAUUGGGCCUAAAGCGUCC GUAGCCGGGCUGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCCUCCGGGAAAUCUGGCGGCUUAACC- --------------------------------GUCA-GACUGCCGGAGGAUACUGCCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GCCUA--GGGACCGGGA G-AGGCCGGGGGUA-UUCCCGGAGUAGGGGUGAAAUCCUGUAAUCCCGGGAGGACCACCU GUGGCGAAGGCGCCCGGCUGGAACGGGUCCGACGGUGAGGGACGAAGGCCAGGGGAGCGA ACCGGAUUAGAUACCCGG-GUAGUCCUGGCUGUAAACGAUGC-GGACUAGGUGUCACCGA AGC--------------------------------------------------------- ---UACGA---------------------------------------------------- --------------------GCUUCGGUGGU-GCCGGAGGGAAGCC-GUUAAGUC----- -------CGCC-GCCUGGGGAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACUACAA-CGGGUGGAGCCUGCGGUUUAAUUGGAUUCAACGCCGGGAA-GCUU- A-CCG-GGG-GA-GA-CAGCG-GGA-UGAAGGU-CGGGCUGAAGA--CCUU-A-CCAGA- --------------------CUAG-CUGA-GAGGUGGUGCAUGGCCGCCGUCAGUUCGUA CU-GUGAAGCAUCCUGUUAAGUCAGGCAACGAGCGAGACCCG-CGCCC-CCAGUUGCC-A GCGGUUCCC--------------------------------------------------- ------------------------------------------------------------ ----------------U-UC--G------------------------------------- ------------------------------------------------------------ -----------------------------------------GG--GAAGC---------- --C-G---------GGCACACUGGGGGGACU-GCCG-G----CGC-UAAGC-CG-GAGGA AGGUGCGGGCAACGGCAGGUCCGU-AUGCCCCGA-AUCCCCCGGGCUACACGCGGGCUAC AAUG-GCCGGGACAAUGGGU---------------------------------------- ----------------------A-CCGACCCCGAAAGGGGUAGGUAA-UCCC--C-UAAA CCCGGUCUAACCUGGGAUCGAGGGCUGCAACUCGCCCUCGUG-AACCUGGAAUCCGUAGU AAUCGCGC-CUCAAA-AUGGCGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CAAGCCACCCGAG-UGGGCCAG-GGGCGAGGGGGUG-GCC-------------------- ----C-UA---------------------------GGCCA----------CCUUCG-AGC CCAGGGUCCGCGAGGGGGGCUAAGUCGUAACAAGGUAGCCGUAGGGGAAUCUGCGGCUGG AUCACCUCCU------------ >Caldivirga_maquilingensis ----------------AAACCGGUUGAUCCUG-CCGGACCCGAC--CGCUAUCGGG-GUG GGGCUUAGCCAUGCGAGUCAAGCGCCC-CAG---------------------GGACCC-G -------------------------C-UG--GG-GUG-CGGCG-CACGGCUCAGUAACAC GUGGCCAAC-CUACCCUCGGG---------------------AGGGGG-AUAACCC--C- G-GGAAA-CUGGGGCUAAUCCCCCA----------------------------------- ------------------------------------------------------------ ---------UA-GG-GGAAGGGUGC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-G-GCC-CC-CUCCCC-GAAAAGAGCCA--CGUC------------CGGU A-C-CCG-----------GCGCGGCUCGCCCGAGGAUGGGGCUACG-GCCCAUCAUGGUA --GCUGGCGGGGUAACGGCCCG-CCAGGCCGAAGACGGGU-GGGGGCCGUGAGAG-CGGG AGCCCCGAGAUGGGCACUGAGACAAGGGCCCAGGCCCUAUGG-GGUGCAGCAGGCUCGAA UACUCCGCAAUGCGG-UAA----CCCGCGACGGGGCCACCCCGAGU--GCCG------CC CG--AU--G--AGGG-------C-GGCUUUUCCCCCGUG----------------UAA-G U-A-------------------GCUGGGGG-AAUAAGCGGGGGGCAAGUCU-GG-UGUCA GCCGCCGCGGUAAUACCAGCUCCGCGAGUGGUCGGGGUGUUUACUGGGCCUAAAGCGCCC GUAGCCGGCCCGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCACCCCUGAAAUCCAUGGGCUCAACC- --------------------------------CAUG-GGC-CGGGGGUGAUACUGCCG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUU--GGGGGUGGGA G-AGGCCGAGGGUA-CUCCCGGGGUAGGGGCGAAAUCCGAUAAUCCCGGGAGGACCACCA GUGGCGGAAGCGCUCGGCUGGAACACGCCCGACGGUGAGGGGCGAAAGCUGGGGGAGCAA AGGGGAUUAGAUACCCCU-GUAGUCCCAGCUGUAAACGAUGC-GGGCUAGCUGUUGGGUG GGC--------------------------------------------------------- ---UUAGU---------------------------------------------------- --------------------GCCCGCCCAGU-GGCGUAGGGAAGCC-GUUAAGCC----- -------CGCC-GCCUGGGGAGUACGG-CCGCAAACC-UGAAACUUAAAGGAAUUGGCGG GGGGGCACCACAA-GGGGUGAAGCUUGCGGCUUAAUUGGAGUCAACGCCGGAAA-CCUC- A-CCC-GGG-GC-GA-CAGCA-GGA-UGAAGGC-CAGGCUAACGA--CCUU-G-CCGGA- --------------------CGAG-CUGA-GAGGAGGUGCAUGGCCGUCGCCAGCUCGUG CC-GUGAGGUGUCCAGUUAAGUCUGGCAACGAGCGCGACCCC-CGCUC-CCUGUUGCU-A CCCUACCC---------------------------------------------------- ------------------------------------------------------------ ----------------U-UC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--GGUGG---------- --G-G---------GGCACACAGGGAGGACU-GCCG-G----CG--UAAGC-CG-GAGGA AGGAGGGGGCCACGGCAGGUCAGU-AUGCCCCGA-AACCCCGGGGCUGCACGCGAGCUGC AAUG-GCGGGGACAGCGGGU---------------------------------------- ----------------------U-CCGACCCCGAAAGGGGGAGGCAA-UCCC--G-UAAA CCCCGCCCCAGUAGGAAUCGAGGGCUGUAACUCGCCCUCGUG-AACGUGGAAUCCCUAGU AACCGCGU-GUCACC-AACGCGCGGUGAAUACGUCCCUGCCCCUUGCACACACCGCCCGU CGCGCCACCCGAG-GGGAUCCU-UAACGAGGCCCCC-UG--------------------- ----G-GU-A------------------------ACUGGG----------GGGUCG-AGU UGGGGGUCCCCAAGGGGGGCGAAGUCGUAACAAGGUGGCCGUAGGGGAACCUGCGGCCGG AUCACCUCCU------------ >Haloarcula_marismortui ----------------AUUCCGGUUGAUCCUG-CCGGAGGCCAU--UGCUAUCGGA-GUC CGAUUUAGCCAUGCUAGUUGCACGAGU-------------------------UU---A-G -------------------------------AC-UCG-UAGCA-UAUAGCUCAGUAACAC GUGGCCAAA-CUACCCUACAG---------------------ACCGCG-AUAACCU--C- G-GGAAA-CUGAGGCCAAUAGCGGA----------------------------------- ------------------------------------------------------------ ---------UA-UC-ACUCUCAGAC----------------------------------- ------------------------------------------------------------ ---UG-GA-G-U-GUC-GA-GAGUGA-GAAA-CGU----------------------U-- C-C-G-------------------GCG-CUGUAGGAUGUGGCUGCG-GCCGAUUA-GGUA --GAUGGUGGGGUAACGGCCCA-CCAUGCCGAUAAUCGGU-ACAGGUUGUGAGAGCAA-G AGCCUGGAGACGGUAUCUGAGACAAGAUACCGGGCCCUACGG-GGCGCAGCAGGCGCGAA ACCUUUACACUGCAC-GAC----AGUGCGAUAGGGGGACUCCGAGU--GUGA------GG GC--AUAUA--GCCC-------U-CGCUUUUCUGAACCG----------------UAA-G G-U-------------------GGUUCAGG-AACAAGGACUGGGCAAGACC-GG-UGCCA GCCGCCGCGGUAAUACCGGCAGUCCAAGUGAUGGCCGAUAUUAUUGGGCCUAAAGCGUCC GUAGCUUGCUGUG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCCAUUGGGAAAUCGACCAGCUCAACU- --------------------------------GGUC-GGCGUCCGGUGGAAACUACAC-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AGCUU--GGGGCCGAGA G-ACUCAACGGGUA-CGUCCGGGGUAGGAGUGAAAUCCUGUAAUCCUGGACGGACCACCA AUGGGGAAACCACGUUGAGAGACCGGACCCGACAGUGAGGGACGAAAGCCAGGGUCUCGA ACCGGAUUAGAUACCCGG-GUAGUCCUGGCUGUAAACAAUGC-UCGCUAGGUAUGUCACG CGC--------------------------------------------------------- ---CAUGA---------------------------------------------------- --------------------GCACGUGAUGU-GCCGUAGUGAAGAC-GAUAAGCG----- -------AGCC-GCCUGGGAAGUACGU-CCGCAAGGA-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-CCGGAGGAGCCUGCGGUUUAAUUGGACUCAACGCCGGACA-UCUC- A-CCG-GUC-CC-GA-CAGUAGUAA-UGACAGU-CAGGUUGACGA--CUUU-A-CUCGA- --------------------CGCUACUGA-GAGGAGGUGCAUGGCCGCCGUCAGCUCGUA CC-GUGAGGCGUCCUGUUAAGUCAGGCAACGAGCGAGACCCA-CACUU-CUAGUUGCC-A GCAACACC---------------------------------------------------- ------------------------------------------------------------ ----------------C-CU--GC------------------------------------ ------------------------------------------------------------ ------------------------------------------G--GUGGU---------- --U-G---------GGUACACUAGGAGGACU-GCCA-U----UGC-UAAAA-UG-GAGGA AGGAAUGGGCAACGGUAGGUCAGU-AUGCCCCGA-AUGGACCGGGCAACACGCGGGCUAC AAUG-GCUAUGACAGUGGGA---------------------------------------- ----------------------U-GCAACGCCGAAAGGCGAAGCUAA-UCUC--C--AAA CGUAGUCGUAGUUCGGAUUGCGGGCUGAAACCCGCCCGCAUG-AAGCUGGAUUCGGUAGU AAUCGCGU-GUCAGA-AGCGCGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CAAAGCACCCGAG-UGGGGUCC-GGAUGAGGCCGUC------------------------ ----A-UG-C----------------------------GA----------CGGUCG-AAU CUGGGCUCCGCAAGGGGGCUUAAGUCGUAACAAGGUAGCCGUAGAGGAAUCUGCGGCUGG AUCACCUCCU------------ >Halobacterium_sp. ----------------AUUCCGGUUGAUCCUG-CCGGAGGCCAU--UGCUAUCGGA-GUC CGAUUUAGCCAUGCUAGUUGUGCGGGU-------------------------UU---A-G -------------------------------AC-CCG-CAGCG-GAAAGCUCAGUAACAC GUGGCCAAG-CUACCCUGUGG---------------------ACGGGA-AUACUCU--C- G-GGAAA-CUGAGGCUAAUCCCCGA----------------------------------- ------------------------------------------------------------ ---------UA-AC-GCUUUGCUCC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-G-GGG-CA-AAGCCG-GAAA-CGC----------------------U-- C-C-G-------------------GCG-CCACAGGAUGCGGCUGCG-GUCGAUUA-GGUA --GACGGUGGGGUAACGGCCCA-CCGUGCCCAUAAUCGGU-ACGGGUUGUGAGAGCAA-G AGCCCGGAGACGGAAUCUGAGACAAGAUUCCGGGCCCUACGG-GGCGCAGCAGGCGCGAA ACCUUUACACUGUAC-GAA----AGUGCGAUAAGGGGACUCCGAGU--GUGA------AG GC--AUAGA--GCCU-------U-CACUUUUGUACACCG----------------UAA-G G-U-------------------GGUGCACG-AAUAAGGACUGGGCAAGACC-GG-UGCCA GCCGCCGCGGUAAUACCGGCAGUCCGAGUGAUGGCCGAUCUUAUUGGGCCUAAAGCGUCC GUAGCUGGCUGAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUCCGUUGGGAAAUCUGUCCGCUUAACG- --------------------------------GGCA-GGCGUCCAGCGGAAACUGUUC-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AGCUU--GGGACCGGAA G-ACCUGAGGGGUA-CGUCUGGGGUAGGAGUGAAAUCCUGUAAUCCUGGACGGACCGCCG GUGGCGAAAGCGCCUCAGGAGAACGGAUCCGACAGUGAGGGACGAAAGCUAGGGUCUCGA ACCGGAUUAGAUACCCGG-GUAGUCCUAGCUGUAAACGAUGU-CCGCUAGGUGUGGCGCA GGC--------------------------------------------------------- ---UACGA---------------------------------------------------- --------------------GCCUGCGCUGU-GCCGUAGGGAAGCC-GAGAAGCG----- -------GACC-GCCUGGGAAGUACGU-CUGCAAGGA-UGAAACUUAAAGGAAUUGGCGG GGGAGCACUACAA-CCGGAGGAGCCUGCGGUUUAAUUGGACUCAACGCCGGACA-UCUC- A-CCA-GCC-CC-GA-CAGUAGUAA-UGACGGU-CAGGUUGAUGA--CCUU-A-CCCGA- --------------------GGCUACUGA-GAGGAGGUGCAUGGCCGCCGUCAGCUCGUA CC-GUGAGGCGUCCUGUUAAGUCAGGCAACGAGCGAGACCCG-CACUC-CUAAUUGCC-A GCAGUACCC--------------------------------------------------- ------------------------------------------------------------ ----------------U-UU---------------------------------------- ------------------------------------------------------------ -----------------------------------------GG--GUAGC---------- --U-G---------GGUACAUUAGGUGGACU-GCCG-C----UGC-CAAAG-CG-GAGGA AGGAACGGGCAACGGUAGGUCAGU-AUGCCCCGA-AUGGGCUGGGCAACACGCGGGCUAC AAUG-GUCGAGACAAUGGGA---------------------------------------- ----------------------A-GCCACUCCGAGAGGAGGCGCUAA-UCUC--C-UAAA CUCGAUCGUAGUUCGGAUUGAGGGCUGAAACUCGCCCUCAUG-AAGCUGGAUUCGGUAGU AAUCGCGU-GUCAGC-AGCGCGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CAAAUCACCCGAG-UGGGGUUC-GGAUGAGGCCGGC------------------------ ----A-UG-C----------------------------GC----------UGGUCA-AAU CUGGGCUCCGCAAGGGGGAUUAAGUCGUAACAAGGUAGCCGUAGGGGAAUCUGCGGCUGG AUCACCUCCU------------ >Haloferax_volcanii ----------------AUUCCGGUUGAUCCUG-CCGGAGGUCAU--UGCUAUUGGG-GUC CGAUUUAGCCAUGCUAGUUGCACGAGU-------------------------UC---A-U -------------------------------AC-UCG-UGGCG-AAAAGCUCAGUAACAC GUGGCCAAA-CUACCCUACAG---------------------AGAACG-AUAACCU--C- G-GGAAA-CUGAGGCUAAUAGUUCA----------------------------------- ------------------------------------------------------------ ---------UA-CG-GGAGUCAUGC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GCC-GA-CUCCCC-GAAA-CGC----------------------U-- C-A-G-------------------GCG-CUGUAGGAUGUGGCUGCG-GCCGAUUA-GGUA --GACGGUGGGGUAACGGCCCA-CCGUGCCGAUAAUCGGU-ACGGGUUGUGAGAGCAA-G AGCCCGGAGACGGAAUCUGAGACAAGAUUCCGGGCCCUACGG-GGCGCAGCAGGCGCGAA ACCUUUACACUGCAC-GCA----AGUGCGAUAAGGGGACCCCAAGU--GCGA------GG GC--AUAUA--GUCC-------U-CGCUUUUCUCGACCG----------------UAA-G G-C-------------------GGUCGAGG-AAUAAGAGCUGGGCAAGACC-GG-UGCCA GCCGCCGCGGUAAUACCGGCAGCUCAAGUGAUGACCGAUAUUAUUGGGCCUAAAGCGUCC GUAGCCGGCCACG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------AAGGUUCAUCGGGAAAUCCGCCAGCUCAACU- --------------------------------GGCG-GGCGUCCGGUGAAAACCACGU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUU--GGGACCGGAA G-GCUCGAGGGGUA-CGUCCGGGGUAGGAGUGAAAUCCCGUAAUCCUGGACGGACCACCG AUGGCGAAAGCACCUCGAGAAGACGGAUCCGACGGUGAGGGACGAAAGCUAGGGUCUCGA ACCGGAUUAGAUACCCGG-GUAGUCCUAGCUGUAAACGAUGC-UCGCUAGGUGUGACACA GGC--------------------------------------------------------- ---UACGA---------------------------------------------------- --------------------GCCUGUGUUGU-GCCGUAGGGAAGCC-GAGAAGCG----- -------AGCC-GCCUGGGAAGUACGU-CCGCAAGGA-UGAAACUUAAAGGAAUUGGCGG GGGAGCACUACAA-CCGGAGGAGCCUGCGGUUUAAUUGGACUCAACGCCGGACA-UCUC- A-CCA-GCU-CC-GA-CUACAGUGA-UGACGAU-CAGGUUGAUGA--CCUU-AUCACGA- --------------------CGCUGUAGA-GAGGAGGUGCAUGGCCGCCGUCAGCUCGUA CC-GUGAGGCGUCCUGUUAAGUCAGGCAACGAGCGAGACCCG-CACUU-CUAAUUGCC-A GCAGCAGU---------------------------------------------------- ------------------------------------------------------------ ----------------U-UC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------A--CUGGC---------- --U-G---------GGUACAUUAGAAGGACU-GCCG-C----UGC-UAAAG-CG-GAGGA AGGAACGGGCAACGGUAGGUCAGU-AUGCCCCGA-AUGAGCUGGGCUACACGCGGGCUAC AAUG-GUCGAGACAAUGGGU---------------------------------------- ----------------------U-GCUAUCUCGAAAGAGAACGCUAA-UCUC--C-UAAA CUCGAUCGUAGUUCGGAUUGAGGGCUGAAACUCGCCCUCAUG-AAGCUGGAUUCGGUAGU AAUCGCAU-UUCAAU-AGAGUGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CAAAGCACCCGAG-UGAGGUCC-GGAUGAGGCCACC------------------------ ----A-CA-C----------------------------GG----------UGGUCG-AAU CUGGGCUUCGCAAGGGGGCUUAAGUCGUAACAAGGUAGCCGUAGGGGAAUCUGCGGCUGG AUCACCUCCU------------ >Haloquadratum_walsbyi ----------------AUUCCGGUUGAUCCUG-CCGGAGGCCAU--UGCUAUCGGA-GUC CGAUUUAGCCAUGCUAGUCGUGCGAGU-------------------------UC---A-G -------------------------------AC-UCG-CGGCA-CCGAGCUCAGUAACAC GUGGCCAAA-CUACCCUACAG---------------------AGACGG-AUACCCU--C- G-GGAAA-CUGAGGUUAACCCGUCA----------------------------------- ------------------------------------------------------------ ---------UA-CC-GAUCUCAGGC----------------------------------- ------------------------------------------------------------ ---UU-GA-A-U-CGCAGA-GAUCAC-AAAA-CGC----------------------C-- C-C-G-------------------GCG-CUGUAGGAUGUGGCUGCG-GUUGAUUA-GGUA --GACGGUGGGGUAACGGCCCA-CCGUGCCCAUAAUCAGU-ACAGGUUGUGAGAGCAA-G AACCUGGAGACGGAAUCUGAGACAAGAUUCCGGGCCCUACGG-GGCGCAGCAGGCGCGAA ACCUUUACACUGCAC-GCA----CGUGCGAUAAGGGGACUCCGAGU--GCGA------GG GC--AUAUC--GUCC-------U-CGCUUUCGUGUACCG----------------UAG-G G-U-------------------GGUACACC-AACAAGGGCUGGGCAAGACC-GG-UGCCA GCCGCCGCGGUAAUACCGGCAGCCCGAGUGAUGGCCGAUCUUAUUGGGCCUAAAGCGUCC GUAGCUGGCUGCG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUCCGUCGGGAAAUCCACUCGCCCAACG- --------------------------------AGUG-GGCGUCCGACGGAAACUGCAC-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AGCUU--GGGACCGGAA G-GCUCGAAGGGUA-CGUUCGGGGUAGGAGUGAAAUCCCAUAAUCCCGCACGGACCACCG AUGGCGAAAGCACUUCGAGAAAACGGAUCCGACAGUGAGGGACGAAAGCCAGGGUCUCCA ACCGGAUUAGAUACCCGG-GUAGUCCUGGCCGUAAACAAUGU-UCGCUAGGUAUGACACA GAC--------------------------------------------------------- ---UACGU---------------------------------------------------- --------------------GUCUCUGUUGU-GCCGUAGGGAAGCC-GAGAAGCG----- -------AACC-GCCUGGGAAGUACGU-CUGCAAGGA-UGAAACUUAAAGGAAUUGGCGG GGGAGCACUACAA-CCGGAGGAGCCUGCGGUUUAAUUGGACUCAACGCCGGACA-UCUC- A-CCA-GCU-CC-GA-CUACAGUGA-UGACGAC-CAGGUUGAUGA--CCUC-AUCACGA- --------------------CGCUGUAGA-GAGGAGGUGCAUGGCCGCCGUCAGCUCGUA CC-GUGAGGCGUCCUGUUAAGUCAGGCAACGAGCGAGACCCG-CACCC-CUAAUUGCC-A GCAACAGU---------------------------------------------------- ------------------------------------------------------------ ----------------U-UC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------A--CUGGU---------- --U-G---------GGUACAUUAGGAGGACU-GCCA-G----UGU-UAAAC-UG-GAGGA AGGAACGGGCAACGGUAGGUCAGU-AUGCCCCGA-AUGAGCUGGGCAACACGCGGGCUAC AAUG-GCUAAGACAAUGGGU---------------------------------------- ----------------------C-GCUAUCUCGACAGAGAACGCUAA-UCUC----GAAA CUUAGUCGUAGUUCGGAUUGAGGGCUGAAACUCGCCCUCAUG-AAGCUGGAUUCGGUAGU AGCCGCCU-UUCAGU-AGAAGGCGACGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CAAAGCACCCGAG-UGAGGUCC-GGAUGAGGCUAUC------------------------ ----A-UU------------------------------GA----------UAGUCG-AAU CUGGGCUUCGCAAGGGGGCUUAAGUCGUAACAAGGUAGCCGUAGGGGAAUCUGCGGCUGG AUCACCUCCU------------ >Halorubrum_lacusprofundi ----------------AUUCCGGUUGAUCCUG-CCGGAGGCCAU--UGCUAUUGGG-AUU CGAUUUAGCCAUGCUAGUCGCACGAGU-------------------------UC---A-G -------------------------------AC-UCG-UGGCG-AAUAGCUCAGUAACAC GUGGCCAAA-CUACCCUUCGG---------------------AGCACG-AUACCCU--C- G-GGAAA-CUGAGGUUAAUAGUGCA----------------------------------- ------------------------------------------------------------ ---------UA-CC-ACAAUCCACC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GAG-GA-UUGUGC-CAAA-UGC----------------------U-- C-C-G-------------------GCG-CCGAAGGAUGUGGCUGCG-GCCGAUUA-GGUA --GACGGUGGGGUAACGGCCCA-CCGUGCCAAUAAUCGGU-ACGGGUCAUGAGAGUGA-G AACCCGGAGACGGAAUCUGAGACAAGAUUCCGGGCCCUACGG-GGCGCAGCAGGCGCGAA ACCUUUACACUGCAC-GCC----AGUGCGAUAAGGGAAUCCCAAGU--GCGU------AG GC--AUAGA--GCCU-------A-CGCUUUUGUACACCG----------------UAG-G G-A-------------------GGUGUACG-AAUAAGGGCUGGGCAAGACC-GG-UGCCA GCCGCCGCGGUAAUACCGGCAGCCCGAGUGAUGGCCGAUCUUAUUGGGCCUAAAGCGUCC GUAGCUGGCCGCG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUCUAUCGGAAAAUCCACCCGCUCAACG- --------------------------------GGUG-GGCGUCCGGUAGAAACUGCGU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUU--GGGACCGGAA G-GCGCGACGGGUA-CGUCCGGGGUAGGAGUGAAAUCCUGUAAUCCUGGACGGACCGCCG AUGGCGAAAGCACGUCGCGAGGACGGAUCCGACAGUGAGGGACGAAAGCCAGGGUCUCGA ACCGGAUUAGAUACCCGG-GUAGUCCUGGCCGUAAACAAUGU-CUGUUAGGUGUGGCUCC CAC--------------------------------------------------------- ---UACGA---------------------------------------------------- --------------------GUGGGUGCUGU-GCCGUAGGGAAGCC-GCUAAACA----- -------GACC-GCCUGGGAAGUACGU-CCGCAAGGA-UGAAACUUAAAGGAAUUGGCGG GGGAGCACUACAA-CCGGAGGAGCCUGCGGUUUAAUUGGACUCAACGCCGGACA-UCUC- A-CCA-GCG-UC-GA-CUGUAAUAA-UGACGAU-CAGGUUGAUGA--CCUU-A-UCCGA- --------------------GUUU-CAGA-GAGGAGGUGCAUGGCCGCCGUCAGCUCGUA CC-GUGAGGCGUCCUGUUAAGUCAGGCAACGAGCGAGACCCG-CAUCC-UUACUUGCC-A GCAGCACU---------------------------------------------------- ------------------------------------------------------------ ----------------G-CG--A------------------------------------- ------------------------------------------------------------ ------------------------------------------A--GUGGC---------- --U-G---------GGGACAGUAGGGAGACC-GCCG-U----GGC-CAACA-CG-GAGGA AGGAACGGGCAACGGUAGGUCAGU-AUGCCCCGA-AUGCGCUGGGCAACACGCGGGCUAC AAUG-GUCGAGACAAAGGGU---------------------------------------- ----------------------U-CCAACUCCGAAAGGAGACGGUAA-UCUC--A-GAAA CUCGAUCGUAGUUCGGAUUGUGGGCUGCAACUCGCCCACAUG-AAGCUGGAUUCGGUAGU AAUCGCGU-GUCAUA-AGCGCGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CAAAGCACCCGAG-UGAGGUCC-GGAUGAGGCUCGU------------------------ ------UA-C----------------------------AC----------GAGUCG-AAU CUGGGCUUCGCAAGGGGGCUUAAGUCGUAACAAGGUAGCCGUAGGGGAAUCUGCGGCUGG AUCACCUCCA------------ >Hyperthermus_butylicus ----------------ACUCCGGUUGAUCCUG-CCGGACCCGAC--CGCUAUCGGG-GUG GGACUAAGCCAUGGGAGUCGUGCGCCC-CCG---------------------GA---U-G -------------------------C-GG--GG-GCG-CGGCG-GACGGCUGAGUAACAC GUGGCUAAC-CUACCCUCGGG---------------------ACGGGG-AUAACCC--C- G-GGAAA-CUGGGGCUAAUCCCCGA----------------------------------- ------------------------------------------------------------ ---------UA-GG-CGAGGGGGCC----------------------------------- ------------------------------------------------------------ ---UG-GA-ACG-GGU-CC-CUCGCC-GAAAGGGCGCG--CGG------------AGC-- U-U-CC------------CCGCGCGCCGCCCGAGGAUGGGGCUGCG-GCCCAUCA-GGUA --GUUGGCGGGGUAACGGCCCG-CCAAGCCGAUAACGGGU-AGGGGCCGUGGGAGCGG-G ACCCCCCAGAUGGGCACUGAGACAAGGGCCCAGGCCCUACGG-GGCGCACCAGGCGCGAA ACCUCCGCAAUGCGG-GCA----ACCGUGACGGGGUCACCCCGAGU--GCCG------CC ----GAUAA----GG-------C-GGCUGUUCCCCGCUG----------------UAA-G A-A-------------------GGCGGGGG-AGUAAGCGGGGGGCAAGUCU-GG-UGUCA GCCGCCGCGGUAAUACCAGCCCCGCGAGCGGUCGGGAUGCUUACUGGGCCUAAAGCGCCC GUAGCCGGCCCGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCCCCCCCUAAAGCCCCGGGCUCAACC- --------------------------------CGGG-GAG-UGGGGGGGAUACUACCG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GGGGGCGGGA G-AGGCCGAGGGUA-CUCCCGGGGUAGGGGCGAAAUCCGAUAAUCCCGGGAGGACCACCA GUGGCGAAGGCGCUCGGCUGGAACGCGCCCGACGGUGAGGGGCGAAAGCCGGGGGAGCAA ACCGGAUUAGAUACCCGG-GUAGUCCCGGCUGUAAACGAUGC-GGGCUAGGUGUUGGGCG GGC--------------------------------------------------------- ---UUGGA---------------------------------------------------- --------------------GCCCGCCCAGU-GCCGCAGGGAAGCC-GUUAAGCC----- -------CGCC-GCCUGGGGAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-GGGGUGGAGCCUGCGGCUUAAUUGGAGUCAACGCCGGGAA-UCUU- A-CCG-GGG-GC-GA-CAGCA-GGA-UGACGGC-CAGGCUGACGA--CCUU-G-CCCGA- --------------------CGCG-CUGA-GAGGAGGUGCAUGGCCGUCGCCAGCUCGUG CC-GUGAGGUGUCCGGUUAAGUCCGGCAACGAGCGAGACCCC-CACCC-CUAGUUGCU-A CCCCGGGG---------------------------------------------------- ------------------------------------------------------------ ----------------G-CC--A------------------------------------- ------------------------------------------------------------ ------------------------------------------C--CCC-G---------- --G-G---------GGCACACUAGGGGGACU-GCCG-C----CGUCCAAGG-CG-GAGGA AGGAGGGGGCCACGGCAGGUCAGC-AUGCCCCGA-AUCCCCCGGGCUGCACGCGGGCUAC AAUG-GCGGGGACAGCGGGA---------------------------------------- ----------------------U-CCGACCCCGAAAGGGGGAGGCAA-UCCC--U-UAAA CCCCGCCGCAGUUGGGAUCGAGGGCUGCAACUCGCCCUCGUG-AACGCGGAAUCCCUAGU AACCGCGC-GUUAGC-AUCGCGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CGCUCCACCCGAG-CGGGGGAG-GGGUGAGGCCCUG-CCCCUGGGG-------------- ----G-CA-A-------------------CCCCGGGGGUG----------GGGUCG-AAC CCCUCCCCCGCGAGGGGGGAGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCU------------ >Ignicoccus_hospitalis -------------GCGACUCCGGUUGAUCCUG-CCGGACCCGAC--CGCUAUCGGG-GUA AGGCUAAGCCAUGGGAGUCGAACGCCC--GC---------------------CG---C-C -------------------------G-C---GG-GCG-UGGCG-GACGGCUGAGUAACAC GUGGCUAAC-CUACCCUCGGG---------------------AGGGGG-AUAACAC--C- G-GGAAA-CUGGUGCUAAUCCCCCA----------------------------------- ------------------------------------------------------------ ---------UA-GG-GGCGGAGGCC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-G-GGU-UC-CGCCCC-GAAAGGG-GCU--CGGGG----------GGG-- A-A-CG-----------CCCCGAGUCCGCCCGAGGAUGGGGCCGCG-CCCCAUCA-GGUA --GUUGGCGGGGUAAUGGCCCG-CCAAGCCGAAGACGGGU-AGGGGCCGUGGGAGCGG-G AGCCCCCAGAUGGGCACUGAGACAAGGGCCCAGGCCCUACGG-GGCGCACCAGGCGCGAA AACUCCGCAAUGCGG-GCA----ACCGUGACGGGGUUACCCCGAGU--GCCC------CC ----UCUCC----GG-------G-GGCUUUUCCCCGCUG----------------UAA-A C-A-------------------GGCGGGGGUAAUAAGCGGGGGGCAAGUCU-GG-UGUCA GCCGCCGCGGUAAUACCAGCCCCGCGAGUGGUCGGGACGAUUAUUGGGCCUAAAGCGCCC GUAGCCGGCCUGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UGGCCCCCCUCCUAAAGCCCCGGGCUCAACC- --------------------------------CGGG-GAC-UGGAGGGGGUAGCGCCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GGGGGCGGGA G-AGGCCGAGGGUA-CUCCCGGGGUAGGGGCGAAAUCCGAUAAUCCCGGGAGGACCGCCA GUGGCGAAGGCGCUCGGCUGGAACGCGCCCGACGGUGAGGGGCGAAAGCCGGGGGAGCAA ACCGGAUUAGAUACCCGG-GUAGUCCCGGCUGUAAACGAUGC-GGGCUAGGUGUUGGGCG GGC--------------------------------------------------------- ---UUCGA---------------------------------------------------- --------------------GCCCGCCCAGU-GCCGCAGGGAAGCC-GUUAAGCC----- -------CGCC-GCCUGGGGAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-GGGGUGGAGCCUGCGGCUUAAUUGGAGUCAACGCCGGGAA-CCUU- A-CCG-GGG-GC-GA-CAGCA-GGA-UGAAGGU-CAGGCUGAAGA--CCUU-A-CCUGA- --------------------CGCG-CUGA-GAGGAGGUGCAUGGCCGUCGCCAGCUCGUG CC-GUGAGGUGUCCGGUUAAGUCCGGCAACGAGCGAGACCCC-CGUCC-CCAGUUGCU-A CCCGGGGC---------------------------------------------------- ------------------------------------------------------------ ----------------U-CC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--CCC-C---------- --G-G---------GGCACACUGGGGAGACU-GCCG-C----CGUAUAAGG-CG-GAGGA AGGAGGGGGCUAUGGCAGGUCAGC-AUGCCCCGA-AACCCCCGGGCUGCACGCGGGCUAC AAUG-GCGGGGACAGCGGGU---------------------------------------- ----------------------U-GCGACCCCGAAAGGGGGAGCCAA-UCCC--U-GAAA CCCCGCCGAGGUUGGGAUCGAGGGCUGCAACUCGCCCUCGUG-AACGCGGAAUCCCUAGU AACCGCGC-GUUAGC-AUCGCGCGGUGAACACGUCCCUGCUCCUUGCACACACCGCCCGU CGCUCCACCCGAG-GGGACGGG-UGGUGAGGCCCCC-GUAGG------------------ ----G-AA-A--------------------CUCCCGGGUA----------UCCUCG-AAC UCCCUCCUCUCGAGGGGGGAGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCC------------ >Metallosphaera_sedula ------------------UCCGGUUGAUCCUG-CCGGACCCGAU--CGCUAUAGGG-GUA GGGCUAAGCCAUGGGAGUCGUACGCUC-UCG---------------------GG-----A -------------------------A-GA--GG-GCG-UGGCG-GACGGCUGAGUAACAC GUGGCUAAC-CUGCCCUUGGG---------------------AUCUGG-AUAACCC--C- G-GGAAA-CUGGGGCUAAUCCGGAG----------------------------------- ------------------------------------------------------------ ---------CG-GG-CAAGGGAAUC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GAU-CU-CUUGCC-UAAAAGCCUCU--CGGC-----------UG--- A-U-CCC----------GUCGAGAGGCGCCCAAGGAUGGGGCUGCG-GCCCAUCA-GGCU --GUUGGGGGAGUAAAGGUCCC-CCAAACCGAUAACGGGU-AGGGGCCGUGGGAGCGG-G AGCCCCCAGUUGGGCACUGAGACAAGGGCCCAGGCCCUACGG-GGCGCACCAGGCGCGGA ACGUCCCCAAUGCGG-GAA----ACCGUGAGGGCGUUACCCCUAGU--GCCC------UC ----GC-AA----GA-------G-GGCUUUUCUCCACUC----------------CAG-A A-A-------------------GGUGGAGG-AAUAAGCGGGGGGCAAGACU-GG-UGUCA GCCGCCGCGGUAAUACCAGCCCCGCGAGUGAUCGGGACGUUUAUUGGGCUUAAAGCGCCC GUAGCCGGCCUGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------AAAGUCACCGUUUAAAGACCCGGGCUCAACU- --------------------------------CGGG-GAA-CGGCGGUGAUACUUACA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GGGGGCGGGA G-AGGUCGGAGGUA-CUCCCGGAGUAGGGGCGAAAUCCUCAGAUCCCGGGAGGACCACCA GUGGCGAAAGCGUCCGGCUAGAACGCGCCCGACGGUGAGGGGCGAAAGCCGGGGUAGCAA AUAGGAUUAGAUACCCUA-GUAGUCCCGGCUGUAAACGAUGC-AGGCUAGGUGUCGCGUA GGC--------------------------------------------------------- ---UUUGU---------------------------------------------------- --------------------GCCUGCGCGGU-GCCGCAGGAAAACU-GGUAAGCC----- -------CGCC-GCCUGGGGAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-GGGGUGGAACCUGCGGCUCAAUUGGAGUCAACGCCUGGAA-UCUC- A-CCG-GGG-GA-GA-CCGCA-GGA-UGACGGC-CAGGCUAACGA--CCUU-G-CCAGA- --------------------CUCG-CGGA-GAGGAGGUGCAUGGCCGUCGCCAGCUCGUG UU-GUGAAAUGUCCGGUUAAGUCCGGCAACGAGCGAGACCCC-CACUU-CUAGUUGGU-A ACCGUCUC---------------------------------------------------- ------------------------------------------------------------ ----------------U-CC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--AGA-C---------- --G-G---------UCCACACUAGAAGGACU-GCCG-G----UGU-UAAAC-CG-GAGGA AGGAGGGGGCCACGGCAGGUCAGC-AUGCCCCGA-AACUUCCGGGCCGCACGCGGGUUAC AAUG-GCAGGGACAGCGGGA---------------------------------------- ----------------------U-CCGACCCCGAGAGGGGAAGGCAA-UCCC--A-CAAA CCCUGCCUCAGUUGGGAUCGAGGGCUGAAACUCGCCCUCGUG-AACGAGGAAUCCCUAGU AACCGCGG-GUCAAC-AACCCGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CGCUCCACCCGAG-UGGAGGGG-AAGUGAGGCCUCU-UGCCC------------------ ----C-UC-G-----------------------GGGUGGG----------AGGUCG-AGC UUCUCCUCCGCGAGGGGGGAGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCACAUU--------- >Methanocaldococcus_jannaschii ----------------AUUCCGGUUGAUCCUG-CCGGAGGCCAC--UGCUAUCGGG-GUC CGACUAAGCCAUGCGAGUCAAGGGGCU-CCC---------------------UU---C-G -------------------------G-GG--AG-CAC-CGGCG-CACGGCUCAGUAACAC GUGGCUAAC-CUACCCUCGGG---------------------UGGGGG-AUAACCU--C- G-GGAAA-CUGAGGCUAAUCCCCCA----------------------------------- ------------------------------------------------------------ ---------UA-GG-GGAGGAGGUC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GAU-CC-CUCCCC-GAAA-GGC----------------------G-- U-A-A-------------------GCCGCCCGAGGAUGGGGCUGCG-GCGGAUUA-GGUA --GUUGGUGGGGUAACGGCCCA-CCAAGCCUACGAUCCGU-ACGGGCCCUGAGAGGGG-G AGCCCGGAGAUGGACACUGAGACACGGGUCCAGGCCCUACGG-GGCGCAGCAGGCGCGAA ACCUCCGCAAUGCGC-GAA----AGCGCGACGGGGGGACCCCGAGU--GCCC------AC GC--CC--U--GCGU-------G-GGCUUUUCCGGAGUG----------------UAA-A C-A-------------------GCUCCGGG-AAUAAGGGCUGGGCAAGUCC-GG-UGCCA GCAGCCGCGGUAAUACCGGCGGCCCAAGUGGUGGCCACUGUUAUUGGGCCUAAAGCGUCC GUAGCCGGCCCGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUCUGCUUAAAUCCUGCGGCUCAACC- --------------------------------GCAG-GGC-UGGCAGAGAUACUGCCG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUU--GGGACCGGGA G-AGGCCGGGGGUA-CCCCAGGGGUAGCGGUGAAAUGCGUUGAUCCCUGGGGGACCACCU GUGGCGAAGGCGCCCGGCUGGAACGGGUCCGACGGUGAGGGACGAAGGCCAGGGGAGCAA ACCGGAUUAGAUACCCGG-GUAGUCCUGGCUGUAAACUCUGC-GGACUAGGUGUCGCGUC GGC--------------------------------------------------------- ---UUCGG---------------------------------------------------- --------------------GCCGACGCGGU-GCCGAAGGGAAGCC-GUUAAGUC----- -------CGCC-GCCUGGGGAGUACGG-UCGCAAGAC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACUACAA-CGGGUGGAGCCUGCGGUUUAAUUGGAUUCAACGCCGGGCA-UCUU- A-CCA-GGG-GC-GA-CGGCA-GGA-UGAAGGC-CAGGUUGACGA--CCUU-G-CCAGA- --------------------CGCG-CCGA-GAGGUGGUGCAUGGCCGUCGUCAGCUCGUA CC-GUGAGGCGUCCUGUUAAGUCAGGUAACGAGCGAGACCCG-UGCCC-CAUGUUGCU-A CCUCCUCC---------------------------------------------------- ------------------------------------------------------------ ----------------U-CC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--GAG-G---------- --A-G---------GGCACUCAUGGGGGACC-GCCG-G----CGC-UAAGC-CG-GAGGA AGGUGCGGGCAACGACAGGUCCGC-AUGCCCCGA-AUCCCCUGGGCUACACGCGGGCUAC AAUG-GCCGGGACAAUGGGA---------------------------------------- ----------------------C-GCGACCCCGAAAGGGGGAGCGAA-UCCC--C-UAAA CCCGGUCGUAGUCCGGAUCGAGGGCUGUAACUCGCCCUCGUG-AAGCCGGAAUCCGUAGU AAUCGCGC-CUCACC-AUGGCGCGGUGAAUGCGUCCCUGCUCCUUGCACACACCGCCCGU CACGCCACCCGAG-UUGAGCCC-AAGUGAGGCCCUG-UCC-------------------- ----G-CA-A-------------------------GGGCA----------GGGUCG-AAC UUGGGUUCAGCGAGGGGGGCGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCC------------- >Methanococcoides_burtonii ----------------ACUCUGGUUGAUCCUG-CCAGAGGUUAC--UGCUAUCGGU-GUU CGACUAAGCCAUGCGAGUCAUAUGUUC-------------------------UU---C-G U------------------------------GA-ACA-UGGCG-GACUGCUCAGUAACAC GUGGAUAAC-CUGCCCUUAGG---------------------UUUGGC-AUAACUC--C- G-GGAAA-CUGGAGAUAAUUCCGAA----------------------------------- ------------------------------------------------------------ ---------UA-GG-UCAAAUAUGC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GCU-UU-UUGAUC-AAAA-GAC----------------------U-- U-C-G-------------------GUUGCCUAAGGAUGGAUCUGCG-GUCUAUCA-GGUU --GUAGUGGGUGUAACGUACCU-ACUAGCCUACGACGGAU-AUGGGUUGUGAGAGCAA-G AGCCCAGAGAUGGAUUCUGAGACAUGAAUCCAGGCCCUACGG-GGCGCAGCAGGCGCGAA AUCUUUACAAUGCGG-GAA----ACCGCGAUAAGGGGACACCGAGU--GCCA------GC A---UU-UA---UGU-------U-GGCUGUCCACAUGUG----------------UAA-A C-G-------------------GCAUGUGUUAGCAAGGGCCGGGCAAGACC-GG-UGCCA GCCGCCGCGGUAACACCGGCGGCCCGAGUGGUAAUCACUUUUAUUGGGUCUAAAGGGUCC GUAGCCGGUUUGA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UCAGUUCUUCGGGAAAUCUGACAGCUCAACU- --------------------------------GUUA-GGCUUCCGGGGAAUACUGUCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUU--GGGACCGGGA G-AGGUAAGAGGUA-CUACAGGGGUAGGAGUGAAAUCUUGUAAUCCCUGUGGGACCACCA GUGGCGAAGGCGUCUUACCAGAACGGGUCCGACGGUGAGGGACGAAAGCUGGGGGCACGA ACCGGAUUAGAUACCCGG-GUAGUCCCAGCCGUAAACGAUGU-UCGCUAGGUGUCAGGGG CGG--------------------------------------------------------- ---UGCGA---------------------------------------------------- --------------------CCGCUUCUGGU-GCCGUAGGGAAGCC-GUGAAGCG----- -------AACC-ACCUGGGAAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACUACAA-CGGGUGGAGCCUGCGGUUUAAUUGGACUCAACGCCGGAAA-ACUC- A-CCG-GGG-GC-GA-CAGCA-AAA-UGUAGGU-CAAGCUAAAGA--CUUU-A-CCUGA- --------------------AUCG-CUGA-GAGGAGGUGCAUGGCCGUCGUCAGUUCGUA CU-GUGAAGCAUCCUGUUAAGUCAGGCAACGAGCGAGACCCG-UGCCC-ACUGUUGCC-A GCAUGUCC---------------------------------------------------- ------------------------------------------------------------ ----------------U-UC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--GAUGA---------- --U-G---------GGUACUCUGUGGGGACC-GCUG-G----UGC-UAAAC-CA-GAGGA AGGUGCGGGCUACGGUAGGUCAGU-AUGCCCCGA-AUCUCCCGGGCUACACGCGGGCUAC AAUG-GUUGGGACAAUGGGU---------------------------------------- ----------------------U-CCUACACCGAAAGGUGAUGGCAA-UCUC--C-UAAA CCCAACCGUAGUUCGAAUUGAGGACUGUAACUCGUCCUCAUG-AAGCUGGAAUCCGUAGU AAUCGCGU-UUCAAC-AUAGCGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CAAACCACCCGAG-UGAGGUAU-GGGUGAGGGCACG-GAC-------------------- ----U-UA-G-------------------------UGCCG----------UGUUCG-AAC CUAAAUUUCGCAAGGGGGGUUAAGUCGUAACAAGGUAGCCGUAGGGGAAUCUGCGGCUGG AUCACCUCCU------------ >Methanococcus_aeolicus ------------------UCCGGUUGAUCCCG-CCGGAGGCUAC--UGCUAUUGGG-AUU CGACUAAGCCAUGCGAGUCU-AUGGAC-------------------------UU---C-G -------------------------------GU-CCA-UGGCG-GACGGCUCAGUAACAC GUGGCUAAC-CUACCCUCAGG---------------------UGGGGC-AUAACCU--C- G-GGAAA-CUGAGGAUAAUACCCCA----------------------------------- ------------------------------------------------------------ ---------UA-GG-AAAAGAGGUU----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-AAU-CC-UUUUCU-GAAA-GG-----------------------A-- U-A-U--------------------CCGCCUGAGGAUGGGGCUGCG-UCCGAUUA-GGUA --GUUGGUGGGGUAAUGGCCCA-CCAAGCCUACGAUCGGU-ACGGGCCUUGAGAGAGG-G AGCCCGGAGAUGGGGACUGAGACACGGCCCCAGGCCCUACGG-GGCGCAGCAGGCGCGAA ACCUCCACAAUGCAC-GAA----AGUGCGAUGGGGGAAUCCCAAGU--GCCU------AU GC--AC--A--GCAU-------A-GGCUUUUCCCAAGUC----------------UAA-A C-A-------------------ACUUGGGG-AAUAAGGGCUGGGCAAGUCC-GG-UGCCA GCAGCCGCGGUAACACCGGCGGCCCGAGUGGUAGCCACUCUUAUUGGGCCUAAAGCGUCC GUAGCCUGUUCAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUCUGUUUAAAUCCUACGGCUUAACC- --------------------------------GUAG-GGC-UGGCAGAGAUACUGCUG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUU--GGGACCGGGA G-AGGAAGAGGGUA-CUUCGGGGGUAGCGGUGAAAUGCGUUGAUCCCUGAGGGACCACCU AUGGCGAAGGCACUCUUCUGGAACGGGUCCGACGGUGAGGGACGAAAGCCAGGGGAGCGA ACCGGAUUAGAUACCCGG-GUAGUCCUGGCCGUAAACUUUGC-GAACUAGGUGUCAUCUG GAC--------------------------------------------------------- ---CUCGG---------------------------------------------------- --------------------GUCCAGGUGGU-GCCGAAGGGAAGCC-AUUAAGUU----- -------CGCC-GCCUGGGGAGUACGG-UCGCAAGAC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-CGGGUGGAGCCUGCGGUUUAAUUGGAUUCAACGCCGGGCA-UCUC- A-CCA-GGA-GC-GA-CAGCA-UGA-UGAAGGU-CAGGUUGACGA--CCUU-A-CCUGA- --------------------AGCG-CUGA-GAGGUGGUGCAUGGCCAUCGUCAGCUCGUA CC-GCGAGGCGUCCUGUUAAGUCAGGUAACGAGCGAGACCCG-UGCCC-UAUGUUGCU-A CUUUCUUC---------------------------------------------------- ------------------------------------------------------------ ----------------U-CC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--AGG-A---------- --A-A---------GGCACUCAUAGGGGACC-GCUG-G----UGU-UAAAC-CA-GAGGA AGGAGCGGGCAACGAUAGGUCCGC-AUGCCCCGA-AUCUCCUGGGCUACACGCGGGCUAC AAUG-GUUAGGACAAUGGGA---------------------------------------- ----------------------A-GCAACCCUGAGAAGGGAAGCAAA-UCUC--U-UAAA CCUAAUCGUAGUUCGGAUCGUGGGCUGUAACUCGCCCACGUG-AAGCUGGAAUCCGUAGU AAUCGCAG-UUCAUA-AUACUGCGGUGAAUGUGUCCCUGCUCCUUGCACACACCGCCCGU CACACCACCCGAG-UUGGGUUG-AGGUGAGGCCCUA-GCC-------------------- ----U-UU---------------------------GGCUA----------AGGUCG-AAC CUGGGCUCAGCAAGGGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCU------------ >Methanocorpusculum_labreanum ------------------UCUGGUUGAUCCUG-CCAGAGGCCAU--UGCUAUCAGG-GUU UGACUAAGCCAUGCGAGUCGAGAGGU--------------------------GU---A-A G-------------------------------A-CCU-CGGCA-UACUGCUCAGUAACAC GUGGUUAAC-CUGCCCUAAGG---------------------UGGAGA-AUACUCC--C- G-GGAAA-CUGGGGCUAAUGCUCCA----------------------------------- ------------------------------------------------------------ ---------UA-GU-GGAUAUGUCC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GGU-AU-AUCCUC-GAAA--GA----------------------U-- C-C-G-------------------UC-GCCUUAGGAUGGGACUGCG-UCCGAUUA-GGUU --GUUGGCGGGGUAACGGCCCA-CCAAGCCUUUUAUCGGU-ACGGGUUGUGGGAGCAA-G AUCCCGGAGAUGGAUUCUGAGACAUGAAUCCAGGCCCUACGG-GGCGCAGCAGGCGCGCA AACUUUACAAUGCGA-GCA----AUCGUGAUAAGGAAACCCUGAGU--GCCU------GU ----CG-AU----GC-------A-GGCUGUUCAUAUAUC----------------UAA-A U-C-------------------AUAUGUGA-AGAAAGGGCAGGGCAAGACC-GG-UGCCA GCCGCCGCGGUAAUACCGGCUGCUCGAGUGAUGGCCACUAUUACUGGGUUUAAAGCGUCC GUAGCUUGACUGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAGGUCUCUUGGGAAAUCUUCGCGCUCAACG- --------------------------------UGAA-GGCGUCUAAGAGAUACCGGCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GUCUU--GGAACUGGGA G-AGGUAAACCGUA-CUUCGGGGGUAGGAGUGAAAUCUUGUAAUCCUCGAGGGACGACCU AUGGCGAAGGCAGUUUACCAGAACAGCUUCGACAGUGAGGGACGAAAGCUGGGGGAGCAA ACGGGAUUAGAUACCCCG-GUAGUCCCAGCCGUAAACAAUGU-GCGUUAGGUGUGUCGGU AAC--------------------------------------------------------- ---CACGU---------------------------------------------------- --------------------GUUACUGAUGC-GCCGAAGAGAAAUC-GUGAAACG----- -------CACC-ACCUGGGAAGUACGG-UCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-CAGGUGGAGCCUGCGGUUUAAUUGGAUUCAACGCCGGACA-UCUC- A-CCG-GAU-AA-GA-CAGCU-GAA-UGAUUGU-CAAUCUGAAGG--UUUU-A-CAUGA- --------------------CUAG-CUGA-GAGGAGGUGCAUGGCCGUCGUCAGUUCGUA CU-GUGAAGCAUCCUGUUAAGUCAGGCAACGAGCGAGACCCA-CGCCG-ACAAUUGCC-A GCAGCAUC---------------------------------------------------- ------------------------------------------------------------ ----------------U-CC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--AUGGC---------- --U-G---------GGGACAUUGUCGGGACC-GCCU-C----UGC-UAAAG-GG-GAGGA AGGAAUGGGCAACGGUAGGUCAGC-AUGCCCCGA-AUUAUCCGGGCUACACGCGGGCUAC AAUG-GACGGGACAAUGGGU---------------------------------------- ----------------------A-ACAACACCGAAAGGUGCAGUCAA-UCUC--C-GAAC CCCGCCCUUAGUUAGGAUUGCGGGUUGCAACUCACCCGCAUG-AAUCUGGAAUCUGUAGU AAUCGCGU-UUCACU-AUAGCGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CAAACCAUCCUAG-UGGGGUUU-GGAUGAGUCCCUG-GU--------------------- ----C-UU-U--------------------------GCCG----------GGGUCG-AAU CUAGGUUCCGUGAGGAGGGUUAAGUCGUAACAAGGUAGCCGUAGGGGAAUCUGCGGCUGG AUCACCUCCU------------ >Methanoculleus_marisnigri ------------------UCUGGUUGAUCCUG-CCAGAGGUCAC--UGCUAUCGGG-GUU CGAUUAAGCCAUGCGAGUCGAGAGGG--------------------------UU---C-G G------------------------------CC--CU-CGGCG-UACUGCUCAGUAACAC GUGGAUAAC-CUGCCCUAAGG---------------------AAGGGG-AUAACCC--C- G-GGAAA-CUGGGAAUAAUACCCUA----------------------------------- ------------------------------------------------------------ ---------UA-GG-UUACAGAUGC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GCU-CU-GUAACU-CAAA--GU----------------------U-- C-A-G-------------------GC-GCCUUAGGAUGGAUCUGCG-GCCGAUUA-GGUU --GUUGUUGGGGUAACGGCCCA-ACAAGCCAGUAAUCGGU-ACGGGUUGUGGGAGCAA-G AGCCCGGAGUUGGAUUCUGAGACACGAAUCCAGGCCCUACGG-GGCGCAGCAGGCGCGAA AACUUUACAAUGCGG-GCA----ACCGUGAUAAGGGAACCUCGAGU--GCCU------GU ----AU-AU----GC-------A-GGCUGUCCAGGUGUC----------------UAA-A A-C-------------------ACACCUGA-AGAAAGGGCCGGGCAAGACC-GG-UGCCA GCCGCCGCGGUAAUACCGGCGGCUCGAGUGGUGGCCACUUUUAUUGGGCUUAAAGCGUUC GUAGCUGGGUUGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUCUUGGGAAAUCCGGCGGCUCAACC- --------------------------------GUCG-GGCGUCUAAGAGAUACUGGCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GUCUU--GGAACCGGGA G-AGGUGAGGGGUA-CUUCGGGGGUAGGAGUGAAAUCCUGUAAUCCUCGAGGGACCACCU GUGGCGAAGGCGCCUCACCAGAACGGCUUCGACAGUGAGGGACGAAAGCUGGGGGAGCAA ACCGGAUUAGAUACCCGG-GUAGUCCCAGCCGUAAACGAUGU-GCGUUAGGUGUAUCGAC GAC--------------------------------------------------------- ---CACGA---------------------------------------------------- --------------------GUCGUCGAGGU-GCCGAAGGGAAACC-GUGAAACG----- -------UACC-GCCUGGGAAGUACGG-UCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-CAGGUGGAGCCUGCGGUUUAAUUGGACUCAACGCCGGGAA-UCUC- A-CCG-GAU-AA-GA-CAGCG-GAA-UGAUUGC-CGGGCUGAAGA--CUCU-G-CAUGA- --------------------CUAG-CUGA-GAGGAGGUGCAUGGCCGUCGUCAGUUCGUA CU-GUGAAGCAUCCUGUUAAGUCAGGCAACGAGCGAGACCCA-CGCCA-ACAGUUGCC-A GCAUGAUC---------------------------------------------------- ------------------------------------------------------------ ----------------U-CC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--AUUGA---------- --U-G---------GGGACACUGUUGGGACC-GCCU-C----UGC-UAAAG-AG-GAGGA AGGAAUGGGCAACGGUAGGUCAGC-AUGCCCCGA-AUUAUCCGGGCUACACGCGGGCUAC AAUG-GGCAGGACAAUGGGU---------------------------------------- ----------------------A-UCGACACCGAAAGGUGGAGGCAA-UCUC--C-UAAA CCUGUCCGUAGUUCGGAUUGUGGGCUGUAACUCGCCCACAUG-AAGCUGGAAUCUGUAGU AAUCGCGU-UUCAAA-AUAACGCGGUGAAUGUGUCCCUGCUCCUUGCACACACCGCCCGU CAAACCACCCGAG-UGGGGUUU-GGAUGAGGCUGCG-GU--------------------- ----C-GU-U--------------------------GCCG----------CAGUCG-AAU CUAGGUUCCGCAAGGGGGGUUAAGUCGUAACAAGGUAGCCGUAGGGGAAUCUGCGGCUGG AUCACCUCCU------------ >Methanopyrus_kandleri ----------------ACUCCGGUUGAUCCUG-CCGGAGGCCAC--CGCUAUCGGG-GUC CGACUAAGCCAUGCAAGUCGAGGGCCG-CCCG--------------------GC---A-A ---------------------UG-GG-GG--CG-GCC-CGGCG-GACGGCUCAGUAACAC GUGGGUAAC-CUACCCUCGGG---------------------ACGGGG-AUAACCC--C- GGCGAAA-GUGGGGCUAAUCCCCGA----------------------------------- ------------------------------------------------------------ ---------UA-GG-CGGGGCGGCC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-C-GGU-CC-UCCGCC-GAAA-GGGCCC--GGGC-----------CCA-- U-G-CC-----------GCCCGGGUCCGCCCGAGGAUGGGCCUGCG-GCCGAUUA-GGUA --GUUGGCGGGGUAACGGCCCG-CCAAGCCGAUAAUCGGU-ACGGGCGGUGAGAGCCG-G AGCCCGGAGACGGGGACUGAGACAAGGCCCCGGGCCCUACGG-GGCGCAGCAGGCGCGAA ACCUCCGCAAUGCGG-GCA----ACCGCGACGGGGGGACCCCGAGU--GCCG------UC GGGGCAAAGCCCCGG-------C-GGCUGUACCGGGGUG----------------UAA-A A-A-------------------GCCCCGGGUAGAAAGCGGCGGGCAAGACC-GC-UGCCA GCCGCCGCGGUAAUAGCGGCGCCGCAAGUGGUGGCCGCUUUUAUUGGGCCUAAAGGGGCC GUAGCCGGUCCCG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UGGGUCCCCGCCGAAAGCCCGCGGCUUAACC- --------------------------------GCGG-GAGUCGGCGGGGAAACUGCGG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUU--GGGACCGGGA G-AGGCCGGAGGUA-CCCCCGGGGUAGGGGUGAAAUCCUGUCAUCCCGGGGGGACCGCCA GUGGCGAAGGCGUCCGGCUGGAACGGGUCCGACGGUGAGGGCCGAAAGCCGGGGGAGCAA ACCGGAUUAGAUACCCGG-GUAGUCCCGGCUGUAAACGAUGC-GGACUAGGUGUUGGGGC GGC--------------------------------------------------------- ---CACGA---------------------------------------------------- --------------------GCCGCCCCAGU-GCCGUAGGGAAGCC-GUUAAGUC----- -------CGCC-GCCUGGGGAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-CCGGUGGAGCCUGCGGUUUAAUUGGAUUCAACGCCGGAAA-CCUU- A-CCG-GGG-GC-GA-CAGCA-GGA-UGAAGGC-CAGGUUGACGA--CCUU-G-CCGGA- --------------------CGAG-CUGA-GAGGAGGUGCAUGGCCGCCGUCAGCUCGUG CC-GUGAGGUGUCCUGUUAAGUCAGGUAACGAGCGAGACCCC-CGCCC-GCAGUUGCC-A GCGGGCCCC--------------------------------------------------- ------------------------------------------------------------ ----------------G-UA--A------------------------------------- ------------------------------------------------------------ -----------------------------------------GG--GGCGC---------- --C-G---------GGCACUCUGCGGGGAUC-GCCG-C----CGU-UAAGG-CG-GAUGA AAGUGGGGGCGACGGCAGGUCCGU-AUGCCCCGA-AACCCCCGGGCUACACGCGGGCUAC AAUG-GCGGGGACAAUGGGA---------------------------------------- ----------------------U-CCGACCCCGAAAGGGGGAGGAAA-UCCC--C-UAAA CCCCGUCGUAGUUCGGAUUGCGGGCUGCAACUCGCCCGCAUG-AAGGUGGAAUCGGUAGU AACCGUGC-CUCAGA-AUGGCACGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CACGCCACCCGAG-CCCCCCGG-GGGCAAGCCCCCG-GUCC------------------- ----G-CA-A------------------------GGGCUG----------GGGGCG-AGC CCCCGGGGGGUGAGGGGGGCGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUC-------------- >Methanoregula_boonei ------------------UCUGGUUGAUCCUG-CCAGAGGCCAC--UGCUAUCGGA-GUU CGAUUAAGCCAUGCGAGUCGAGAGGU--------------------------GU---A-A G-------------------------------A-CCU-CGGCA-UACUGCUCAGUAACAC GUGGACAAC-CUACCCUGAAG---------------------AGGGGG-AUAACCC--C- G-GGAAA-CUGGGGAUAAUACCCCA----------------------------------- ------------------------------------------------------------ ---------UA-GG-CUAUGGAUGC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GCU-CU-GUAGUU-GAAA--GG----------------------U-- C-C-G-------------------CC-GCUUCAGGAUGGGUCUGCG-GCCGAUUA-GGUU --GUUGUUGGGGUAACGGCCCA-ACAAGCCUGUAAUCGGU-ACGGGUUGUGGGAGCAA-G AGCCCGGAGAUGGAUUCUGAGACACGAAUCCAGGCCCUACGG-GGCGCAGCAGGCGCGAA AACUUUGCAAUGCGA-GAA----AUCGUGACAAGGGAACUCCGAGU--GCCU------GU ----AA-AA----UC-------A-GGCUGUCCGUCAGUG----------------UAA-A U-A-------------------ACUGGCGA-AGAAAGGGCCGGGCAAGACC-GG-UGCCA GCCGCCGCGGUAAUACCGGCGGCUCGAGUGGUGGCCACUAUUACUGGGCUUAAAGCGUUC GUAGCUGGCUUGU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUCUGGGGAAAUCUUCCGGCUUAACC- --------------------------------GGAA-GGCGUCUCAGGGAUACUGGCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GGGACCGGAA G-AGGUGAGAGGUA-CUCCAGGGGUAGGAGUGAAAUCCUGUAAUCCUUGGGGGACCACCU GUGGCGAAGGCGUCUCACCAGGACGGCUCCGACAGUGAGGAACGAAAGCUGGGGGAGCAA ACCGGAUUAGAUACCCGG-GUAGUCCCAGCUGUAAACGAUGC-GCGUUAGGUGUAUCGGU GAC--------------------------------------------------------- ---CACGA---------------------------------------------------- --------------------GUCACCGAGGU-GCCGAAGAGAAAUC-GUGAAACG----- -------CGCC-GCCUGGGAAGUACGG-UCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-CGGGUGGAGCCUGCGGUUUAAUCGGACUCAACGCCGGGAA-ACUC- A-CCG-GAC-AA-GA-CAGCU-GAA-UGAUAGU-CGGGCUGAAGA--CUCU-A-CUUGA- --------------------CUAG-CUGA-GAGGAGGUGCAUGGCCGUCGUCAGUUCGUA CU-GUGAAGCAUCCUGUUAAGUCAGGCAACGAGCGAGACCCA-CGCCA-ACAGUUGCU-A GCUCGUCC---------------------------------------------------- ------------------------------------------------------------ ----------------U-CC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--GAUGG---------- --A-G---------AGGACACUGUUGGGACC-GCCU-C----UGC-UAAAG-AG-GAGGA AGGAAUGGGCAACGGUAGGUCAGC-AUGCCCCGA-AUUGUCCGGGCUACACGCGGGCUAC AAUG-GGUGGGACAAUGGGU---------------------------------------- ----------------------A-UCGACACCGAAAGGUGAAGGCAA-UCUC--C-UAAA CCCAUCCUUAGUUCGGAUUGUGGGCUGCAACUCGCCCACAUG-AAGCUGGAAUCCGUAGU AAUCGUGU-UUCAAA-AUAGCACGGUGAAUAUGUCCCUGCUCCUUGCACACACCGCCCGU CAAACCACCCGAG-UGAGGUCU-UGAUGAGGUUGUC-GU--------------------- ----U-UU-C-------------------------UGCGG----------CGAUCG-AAU CUAGGUUUUGCAAGGGGGGUUAAGUCGUAACAAGGUAGCCGUAGGGGAAUCUGCGGCUGG AUCACCUCCU------------ >Methanosaeta_thermophila ------------------ACUGGUUGAUCCUG-CCAGAGGUUAC--UGCUAUCGGG-GUC CGACUAAGCCAUGCGAGUUGAAUGUCC-------------------------GA---A-A -------------------------------GG-GCA-UAGCG-CACUGCUCAGUAACAC GUGGACAAC-CUGCCCUGAGG---------------------ACUGGA-AUAAUCC--C- G-GGAAA-CUGGGGGUAAUUCCAGA----------------------------------- ------------------------------------------------------------ ---------UA-UG-UCAGAACUCC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GGG-UU-CUGGCA-GAAAG-GC----------------------U-- C-C-G-------------------GC-GCCUCAGGAUGGGUCUGCG-GCCUAUCAGGGUA --GUAGUGGGUGUAACGUACCU-ACUAGCCUACGACGGGU-ACGGGUUGUGAGAGCAA-G AGCCCGGAGAUGGAUUCUGAGACAUGAAUCCAGGCCCUACGG-GGUGCAGCAGGCGCGAA AACUUUACAAUGCGG-GCA----ACCGCGAUAAGGGGACCUCGAGU--GCUG------GG UU--AC--A--AACC-------U-GGCUGUUGGGCUGCC----------------UAA-A A-A-------------------GCAGUCUAUAGCAAGGGCCGGGCAAGACC-GG-UGCCA GCCGCCGCGGUAACACCGGCGGCUCGAGUGGUAACCGCUAUUAUUGGGUCUAAAGGGUCU GUAGCCGGCCGAC----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUCUUGGGAAAUCUGGCAUCUCAAGU- --------------------------------GUCA-GGCUGCCAGGGGAUACUGGUC-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUU--GGGACCGGGA G-AGGUGAGAGGUA-CCUCGGGGGUAGGGGUGAAAUCUUGUAAUCCUCGAGGGACCACCA GUGGCGAAGGCGUCUCACCAGAACGGAUCCGACGGCAAGGGACGAAAGCUAGGGGCACGA ACCGGAUUAGAUACCCGG-GUAGUCCUAGCCGUAAACGAUAC-UCGCUAGGUGUCGGCCA CGG--------------------------------------------------------- ---UGCGA---------------------------------------------------- --------------------CCGUGGUCGGU-GCCGUAGGGAAGCC-GUGAAGCG----- -------AGCC-ACCUGGGAAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-CGGGUGGAGCCUGCGGUUUAAUUGGAUUCAACGCCGGAAA-GCUU- A-CCG-GGG-GC-GA-CAGCA-AUA-UGAAGGU-CAGGCUGAAGA--CCUU-A-CCGGA- --------------------UUCG-CUGA-GAGGUGGUGCAUGGCCGUCGUCAGUUCGUA CU-GUGAAGCAUCCUGUUAAGUCAGGCAACGAGCGAGACCCA-CGCCC-ACAGUUGCC-A GCGAUCCC---------------------------------------------------- ------------------------------------------------------------ ----------------U-CC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--GGAGG---------- --C-G---------GGUACUCUGUGGGGACC-GCCG-C----UGC-UAAAG-CG-GAGGA AGGAGUGGGCAACGGUAGGUCAGU-AUGCCCCGA-AUCCCCCGGGCUACACGCGGGCUAC AAUG-GUCGGUACAAUGGGU---------------------------------------- ----------------------A-UCGACCCCGAAAGGGGUAGGCAA-UCCC--C-UAAA ACCGAUCGUAGUUCGGAUUGAGGGCUGAAACUCGCCCUCAUG-AAGCUGGAAUCCGUAGU AAUCGCGU-UUCAAC-AGAACGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CAAACCACCCGAG-UAGGGUCC-GGAUGAGGGUGUA-UCC-------------------- ----U-CU---------------------------UGAUA----------CAUUCG-AAU CCGGGCUUUGCAAGGGGGGUUAAGUCGUAACAAGGUAGCCGUAGGGGAAUCUGCGGCUGG AUCACCUCCU------------ >Methanosarcina_acetivorans ----------------AUUCUGGUUGAUCCUG-CCAGAGGUUAC--UGCUAUCGGU-GUU CGCCUAAGCCAUGCGAGUCAUAUGUUC-------------------------UU---U-G U------------------------------GA-ACA-UGGCG-UACUGCUCAGUAACAC GUGGAUAAC-CUGCCCUUGGG---------------------UCCGGC-AUAACCC--C- G-GGAAA-CUGGGGAUAAUACCGGA----------------------------------- ------------------------------------------------------------ ---------UA-AC-GCACAUAUGC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GCU-UU-CUGCGU-AAAACGGA----------------------U-- U-C-G-------------------UCUGCCCAAGGAUGGGUCUGCG-GCCUAUCA-GGUA --GUAGUGGGUGUAACGUACCU-ACUAGCCGACAACGGGU-ACGGGUUGUGAGAGCAA-G AGCCCGGAGAUGGAUUCUGAGACAUGAAUCCAGGCCCUACGG-GGCGCAGCAGGCGCGAA AACUUUACAAUGCGG-GAA----ACCGUGAUAAGGGGACACCGAGU--GCCA------GC AU--CA--U--AUGC-------U-GGCUGUCCGGAUGUG----------------UAA-A A-U-------------------ACAUCUGUUAGCAAGGGCCGGGCAAGACC-GG-UGCCA GCCGCCGCGGUAACACCGGCGGCCCGAGUGGUGAUCGUGAUUAUUGGGUCUAAAGGGUCC GUAGCCGGUUUGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UCAGUCCUCCGGGAAAUCUGACAGCUCAACU- --------------------------------GUUA-GGCUUUCGGGGGAUACUGCCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUU--GGAACCGGGA G-AGGUAAGAGGUA-CUACAGGGGUAGGAGUGAAAUCUUGUAAUCCCUGUGGGACCACCU GUGGCGAAGGCGUCUUACCAGAACGGGUUCGACGGUGAGGGACGAAAGCUGGGGGCACGA ACCGGAUUAGAUACCCGG-GUAGUCCCAGCCGUAAACGAUGC-UCGCUAGGUGUCAGGCA UGG--------------------------------------------------------- ---CGCGA---------------------------------------------------- --------------------CCGUGUCUGGU-GCCGCAGGGAAGCC-GUGAAGCG----- -------AGCC-ACCUGGGAAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACAACAA-CGGGUGGAGCCUGCGGUUUAAUUGGACUCAACGCCGGACA-ACUC- A-CCG-GGG-AC-GA-CAGCA-AUA-UGUAGGC-CAGGCCGAAGA--CCUU-G-CCUGA- --------------------AUCG-CUGA-GAGGAGGUGCAUGGCCGUCGCCAGUUCGUA CU-GUGAAGCAUCCUGUUAAGUCAGGCAACGAGCGAGACCCG-UGCCC-ACUGUUACC-A GCAUGUCC---------------------------------------------------- ------------------------------------------------------------ ----------------U-CC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--GACGA---------- --U-G---------GGUACUCUGUGGGGACC-GCCG-G----UGU-UAAAU-CG-GAGGA AGGUGCGGGCCACGGUAGGUCAGU-AUGCCCCGA-AUUUCCCGGGCUACACGCGGGCUAC AAUG-AAUGGGACAAUGGGU---------------------------------------- ----------------------C-CCUCCCCUGAAAAGGGCUGGUAA-UCUC--A-CAAA CCCAUCCGUAGUUCGGAUCGAGGGCUGUAACUCGCCCUCGUG-AAGCUGGAAUCCGUAGU AAUCGCGU-UUCAAU-AUAGCGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CAAACCACCCGAG-UGAGGUAU-GGGUGAGGGCACG-GAC-------------------- ----U-UC--------------------------GUGCCG----------UGUUCG-AAC CUGAAUUUUGCAAGGGGGGUUAAGUCGUAACAAGGUAGCCGUAGGGGAAUCUGCGGCUGG AUCACCUCCU------------ >Methanosarcina_barkeri ----------------AUUCUGGUUGAUCCUG-CCAGAGGUUAC--UGCUAUCGGU-GUU CGUCUAAGCCAUGCGAGUUAUAUGUUC-------------------------UU---C-G U------------------------------GA-ACA-UGGCG-UACUGCUCAGUAACAC GUGGAUAAC-CUGCCCUUGGG---------------------UCCGGC-AUAACCC--C- G-GGAAA-CUGGGGAUAAUUCCGGA----------------------------------- ------------------------------------------------------------ ---------UA-AC-GCACAUAUGC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GCU-UU-AUGCGU-AAAAUGGA----------------------U-- U-C-G-------------------UCUGCCCAAGGAUGGGUCUGCG-GCCUAUCA-GGUA --GUAGUGGGUGUAAUGUACCU-ACUAGCCUACAACGGGU-ACGGGUUGUGAGAGCAA-G AGCCCGGAGAUGGAUUCUGAGACAUGAAUCCAGGCCCUACGG-GGCGCAGCAGGCGCGAA AACUUUACAAUGCGG-GAA----ACCGUGAUAAGGGGACACCGAGU--GCUA------GC AU--CA--U--AUGC-------U-GGCUGUCCAGGUGUG----------------UAA-A A-U-------------------ACACUUGUUAGCAAGGGCCGGGCAAGACC-GG-UGCCA GCCGCCGCGGUAACACCGGCGGCCCGAGUGGUGAUCGUGAUUAUUGGGUCUAAAGGGUCC GUAGCCGGUUUGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UCAGUCCUCCGGGAAAUCUGAUAGCUCAACU- --------------------------------AUUA-GGCUUUCGGGGGAUACUGCCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUU--GGAACCGGGA G-AGGUAAGAGGUA-CUACAGGGGUAGGAGUGAAAUCUUGUAAUCCCUGUGGGACCACCU GUGGCGAAGGCGUCUUACCAGAACGGGUUCGACGGUGAGGGACGAAAGCUGGGGGCACGA ACCGGAUUAGAUACCCGG-GUAGUCCCAGCCGUAAACGAUGC-UCGCUAGGUGUCAGGCA UGG--------------------------------------------------------- ---CGCGA---------------------------------------------------- --------------------CCGUGUCUGGU-GCCGCAGGGAAGCC-GUGAAGCG----- -------AGCC-ACCUGGGAAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACAACAA-CGGGUGGAGCCUGCGGUUUAAUUGGACUCAACGCCGGACA-ACUC- A-CCG-GGA-AC-GA-CAGCA-AUA-UGUAGGU-CAGGCCGAAGA--CCUU-A-CCUGA- --------------------AUCG-CUGA-GAGGAGGUGCAUGGCCGUCGCCAGUUCGUA CU-GUGAAGCAUCCUGUUAAGUCAGGCAACGAGCGAGACCCG-UGCCC-ACUGUUACC-A GCAUAUCC---------------------------------------------------- ------------------------------------------------------------ ----------------U-CC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--GAUGA---------- --U-G---------GGUACUCUGUGGGGACC-GCCG-G----UGU-UAAAU-CG-GAGGA AGGUGCGGGCUACGGUAGGUCAGU-AUGCCCCGA-AUUUCCCGGGCUACACGCGGGCUAC AAUG-AAUGGGACAAUGGGC---------------------------------------- ----------------------C-CCUCCCCUGAAAAGGGCUGGUAA-UCUC--A-CAAA CCCAUCCUUAGUUCGGAUCGAGGGCUGUAACUCGCCCUCGUG-AAGCUGGAAUCCGUAGU AAUCGCGU-UUCAAU-AUAGCGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CAAACCACCCGAG-UGAGGUAU-GGGUGAGGGCACG-AAC-------------------- ----A-UC--------------------------GUGUCG----------UGUUCG-AAC CUGUGCUUUGCAAGGGGGGUUAAGUCGUAACAAGGUAGCCGUAGGGGAAUCUGCGGCUGG AUCACCUCCU------------ >Methanosarcina_mazei ----------------AUUCUGGUUGAUCCUG-CCAGAGGUUAC--UGCUAUCGGU-GUU CGCCUAAGCCAUGCGAGUCAUAUGUA--------------------------GC---A-A --------------------------------U-ACA-UGGCG-UACUGCUCAGUAACAC GUGGAUAAC-CUGCCCUUGGG---------------------ACCGGC-AUAACCC--C- G-GGAAA-CUGGGGAUAAUUCCGGA----------------------------------- ------------------------------------------------------------ ---------UA-AC-GCAUAUUUGC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GCU-UU-AUGCGU-CAAAAGGA----------------------U-- U-C-G-------------------UCUGCCCAAGGAUGGGUCUGCG-GCCUAUCA-GGUA --GUAGUGGGUGUAAUGUACCU-ACUAGCCAGCGACGGGU-ACGGGUUGUGAGAGCAA-G AGCCCGGAGAUGGAUUCUGAGACAUGAAUCCAGGCCCUACGG-GGCGCAGCAGGCGCGAA AACUUUACAAUGCGG-GAA----ACCGUGAUAAGGGGACACCGAGU--GCCA------GC AU--CA--U--AUGC-------U-GGCUGUCCGGAUGUG----------------UAA-A A-U-------------------ACAUCCGUUAGCAAGGGCCGGGCAAGACC-GG-UGCCA GCCGCCGCGGUAACACCGGCGGCCCGAGUGGUGAUCGUGAUUAUUGGGUCUAAAGGGUCC GUAGCCGGUUUGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UCAGUCCUCCGGGAAAUCUGAUAGCUCAACU- --------------------------------AUUA-GGCUUUCGGGGGAUACUGCCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUU--GGAACCGGGA G-AGGUAAGAGGUA-CUACAGGGGUAGGAGUGAAAUCUUGUAAUCCCUGUGGGACCACCU GUGGCGAAGGCGUCUUACCAGAACGGGUUCGACGGUGAGGGACGAAAGCUGGGGGCACGA ACCGGAUUAGAUACCCGG-GUAGUCCCAGCCGUAAACGAUGC-UCGCUAGGUGUCAGGCA UGG--------------------------------------------------------- ---CGCGA---------------------------------------------------- --------------------CCGUGUCUGGU-GCCGCAGGGAAGCC-GUGAAGCG----- -------AGCC-ACCUGGGAAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACAACAA-CGGGUGGAGCCUGCGGUUUAAUUGGACUCAACGCCGGACA-ACUC- A-CCG-GGG-GC-GA-CAGCA-AUA-UGUAGGC-CAAGCUGAAGA--CUUU-G-CCUGA- --------------------AUCG-CUGA-GAGGAGGUGCAUGGCCGUCGCCAGUUCGUA CU-GUGAAGCAUCCUGUUAAGUCAGGCAACGAGCGAGACCCG-UGCCC-ACUGUUACC-A GCAUGUCC---------------------------------------------------- ------------------------------------------------------------ ----------------U-CC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--GACGA---------- --U-G---------GGUACUCUGUGGGGACC-GCCG-A----UGU-UAAAU-CG-GAGGA AGGUGCGGGCCACGGUAGGUCAGU-AUGCCCCGA-AUCUCCCGGGCUACACGCGGGCUAC AAUG-GAUGGGACAAUGGGU---------------------------------------- ----------------------C-CCUCCCCUGAAAAGGGCUGGUAA-UCUC--A-CAAA CCCAUUCGUAGUUCGGAUCGAGGGCUGUAACUCGCCCUCGUG-AAGCUGGAAUCCGUAGU AAUCGCGU-UUCAAU-AUAGCGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CAAACCACCCGAG-UGAGGUAU-GGGUGAGGGCACG-GAC-------------------- ----U-UC--------------------------GUGCCG----------UGUUCG-AAC CUGUGCUUUGCAAGGGGGGUUAAGUCGUAACAAGGUAGCCGUAGGGGAAUCUGCGGCUGG AUCACCUCC------------- >Methanosphaera_stadtmanae -----AAUAGUGUGUAAAUCCGUUUGAUCCUG-GCGGAAGCUAC--UGCUAUUGGG-AUU CGAUUAAGCCAUGCAAGUCGAAUGAAC-------------------------CU---A-- -------------------------------GU-UCA-UGGCA-UACGGCUCAGUAACAC GUGGAUAAC-UUACCCUUAGG---------------------ACCGGG-AUAACUU--U- G-GGAAA-CUGAAGAUAAUACUGGA----------------------------------- ------------------------------------------------------------ ---------UA-UU-AGGUUAUGCC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GGU-UU-ACCUUU-GAAA-UGU----------------------A-U U-U-U-------------------UCG-CCUAAGGAUAGAUCUGCG-GCUGAUUA-GGUC --GUUGGUGGGGUAAUGGCCCA-CCAAGCCGAUGAUCGGU-ACGGGUUGUGAGAGCAA-G AGCCCGGAGAUGGAACCUGAGACAAGGUUCCAGACCCUACGG-GGUGCAGCAGGCGCGAA ACCUCCGCAAUGUAC-GCA----AGUGCGACGGGGGGAUCCCAAGU--GUUA------UU CU--UA-AC--AGAA-------U-AACUUUUCAUUAGUG----------------UAA-A A-A-------------------GCUUUUAG-AAUAAGAGCUGGGCAAGACC-GG-UGCCA GCCGCCGCGGUAACACCGGCAGCUCAAGUGGUAGCUGUUUUUAUUGGGCCUAAAGCGUUC GUAGCCGGUUUGA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUUUGGUGAAAGCUUGUAGCUUAACU- --------------------------------AUAA-GAAUUGCUGAAGAUACUGUCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUU--GAAGUCGGGA G-AGGUUAGAGGUA-CUACCGGGGUAGGGGUGAAAUCCUAUAAUCCUGGGAGGACCACCU GUGGCGAAGGCGUCUAACUGGAACGAUCUUGACGGUGAGUAACGAAAGCCAGGGGCGCGA ACCGGAUUAGAUACCCGG-GUAGUCCUGGCCGUAAACGAUGU-GGACUUGGUGUUGGAAU GGC--------------------------------------------------------- ---CUCGA---------------------------------------------------- --------------------GUUGUUCCGGU-GCCGAAGGGAAGCU-GUUAAGUC----- -------CACC-GCCUGGGAAGUACGG-UCGCAAGAC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-CGCGUGGAGCCUGCGGUUUAAUUGGAUUCAACGCCGGACA-UCUC- A-CCA-GGA-GC-GA-CAGCA-GAA-UGAUAAU-CAGGUUGAUGA--CCUU-A-UUUGA- --------------------CUAG-CUGA-GAGGAGGUGCAUGGCCGCCGUCAGCUCGUA CU-GUGAAGCGUCCUGUUAAGUCAGGCAACGAGCGAGACCCA-CGCCC-UUAGUUACC-A ACACAAUC---------------------------------------------------- ------------------------------------------------------------ ----------------U-CU--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--AUUGG---------- --U-G---------GGCACACUAGGGGGACC-GCCA-G----UGA-UAAAC-UG-GAGGA AGGAGUGGACGACGGUAGGUCCGU-AUGCCCCGA-AUCUCCUGGGCUACACGCGGGCUAC AAUG-GCUAUGGCAAUGGGU---------------------------------------- ----------------------U-UCUGCACUGAAAAGUGAUGGUAA-UCUC--C-UAAA CAUAGUCUUAGUUCGGAUUGAGGGCUGUAACUCGCCCUCAUG-AAGCUGGAAUGCGUAGU AAUCGCAU-GUCACA-ACCGUGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CACACCACCCAAA-AAGGGUUU-GGAUGAGGCCAUA-AUUU------------------- ----U-CA-A------------------------AUGUUA----------UUGUCG-AAU CUAGGUUUUUUGAGGAGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCUAA---------- >Methanospirillum_hungatei ----------------AUUCUGGUUGAUCCUG-CCAGAGGCCAC--UGCUAUCGGG-GUU UGACUAAGCCAUGCGAGUCGAGAGGU--------------------------GC---A-A G-------------------------------A-CCU-CGGCG-UACUGCUCAGUAACAC GUGGACAAU-CUGCCCUGAAG---------------------AGGAGG-AUAAUCC--C- G-GGAAA-CUGGGGGUAAUACUCCA----------------------------------- ------------------------------------------------------------ ---------UA-GU-UCGUGCUGAC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GUU-AU-GCGAAC-GAAA--GA----------------------U-- C-C-G-------------------UC-GCUUCAGGAUGAGUCUGCG-GCCGAUUA-GGUA --GUUGUUGGGGUAACGGCCCA-ACAAGCCUGUCAUCGGU-ACGGGUUGUGGGAGCAA-G AGCCCGGAGAUGGAUUCUGAGACACGAAUCCAGGCCCUACGG-GGCGCAGCAGGCGCGAA AACUUUACCAUGCGG-GCA----ACCGUGAUAAGGAAACCCCGAGU--GCCA------GC ----AC-AG----GC-------U-GGCUGUCCACCAGUG----------------UAA-A U-A-------------------ACUGGUGA-AGAAAGGGCCGGGCAAGACC-GG-UGCCA GCCGCCGCGGUAAUACCGGCGGCUCGAGUGGUGGCCGCUAUUACUGGGCUUAAAGGGUCC GUAGCUGGAUAUA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUCCCUUGAGAAAUCCGCCGGCUUAACC- --------------------------------GGUG-GGCGUUCAGGGGAAACUGUAU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------UUCUA--GGGACCGGGA G-AGGUGAGAGGUA-CUGCCGGGGUAGGAGUGAAAUCCUGUAAUCCCGGUGGGACCACCU AUGGCGAAGGCAUCUCACCAGAACGGGUCCGACAGUGAGGGACGAAAGCUGGGGGAGCAA ACCGGAUUAGAUACCCGG-GUAGUCCCAGCUGUAAACGAUGC-GCGUUAGGUGUGUCAGU GAC--------------------------------------------------------- ---CACGU---------------------------------------------------- --------------------GUCACUGAGGU-GCCGAAGGGAAACC-GUGAAACG----- -------CGCC-GCCUGGGGAGUACGG-UCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-CGGGUGGAGCCUGCGGUUUAAUCGGACUCAACGCCGGAAA-UCUC- A-CCG-GAU-AA-GA-CAGCU-GCA-UGAUAGU-CGGGAUGAAGA--CUCU-A-CUUGA- --------------------CUAG-CUGA-GAGGAGGUGCAUGGCCGUCGUCAGUUCGUA CU-GUGAAGCAUCCUGUUUAGUCAGGCAACGAGCGAGACCCA-CGCGA-GCAGUUGCC-A GCUUGACC---------------------------------------------------- ------------------------------------------------------------ ----------------U-UC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--GUUGA---------- --U-G---------GGGACACUGCUCGGACC-GCCU-C----UGC-UAAAG-GG-GAGGA AGGAAUGGGCAACGGUAGGUCAGC-AUGCCCCGA-AUUAUCCGGGCUACACGCGGGCUAC AAUG-GACAGGACAAUGGGU---------------------------------------- ----------------------U-UCGACACCGAGAGGUGAGGAUAA-UCUC--C-UAAA CCUGUCCGAAGUUCGGAUUGCGGGUUGUAACUCACCCGCAUG-AAGCUGGAAUCCGUAGU AAUCGCGU-UUCAAC-AUAGCGCGGUGAAUAUGUCCCUGCUCCUUGCACACACCGCCCGU CAAACCACCCGAG-UGAGGUCU-UGAUGAGGAUGUA-UC--------------------- ----A-GU----------------------------GAUA----------UGUUCG-AAU CUGGGUUUUGCAAGGGGGGUUAAGUCGUAACAAGGUAGCCGUAGGGGAAUCUGCGGCUGG AUCACCUCCU------------ >Methanothermobacter_thermautotrophicus -----------------GUCCGUUUGAUCCUG-GCGGAGGCUAC--UGCUAUUGGG-GUU CGAUUAAGCCAUGCAAGUCGAACGAAC-------------------------CU---U-G U------------------------------GU-UCG-UGGCG-AACGGCUCAGUAACAC GUGGAUAAC-CUGCCCUUGGG---------------------ACCGGG-AUAACCC--C- G-GGAAA-CUGGGGAUAAACCCGGA----------------------------------- ------------------------------------------------------------ ---------UA-GG-UGAUGCUGCC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GGU-UC-UUCACC-GAAA-CACC---------------------U-- U-C-G------------------GGUG-CCCAAGGAUGGGUCUGCG-GCCGAUUA-GGUU --GUUGGUAGGGUAACGGCCUA-CCAAGCCGAUCAUCGGU-ACGGGUUGUGAGAGCAA-G AGCCCGGAGAUGGAACCUGAGACAAGGUUCCAGGCCCUACGG-GGCGCAGCAGGCGCGAA ACCUCCGCAAUGCAC-GCA----AGUGCGACGGGGGAACCCCAAGU--GCCA------CU CU--UA-AC--GGGG-------U-GGCUUUUCAGAAGUG----------------UAA-A A-A-------------------GCUUCUGG-AAUAAGGGCUGGGCAAGACC-GG-UGCCA GCCGCCGCGGUAACACCGGCAGCUCAAGUGGUAGCCGCUUUUAUUGGGCCUAAAGCGUCC GUAGCCGGUCUGA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCUCUGGUGAAAUCCCACAGCUUAACU- --------------------------------GUGG-GAAUUGCUGGAGAUACUAUCAU- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUC--GAGGUCGGGA G-AGGCUGGAGGUA-CUCCCAGGGUAGGGGUGAAAUCCUGUAAUCCUGGGAGGACCACCU GUGGCGAAGGCGUCCAGCUGGAACGAACCUGACGGUGAGGGACGAAAGCCAGGGGCGCGA ACCGGAUUAGAUACCCGG-GUAGUCCUGGCCGUAAACGAUGU-GGACUUGGUGUUGGGAU GGC--------------------------------------------------------- ---UUCGA---------------------------------------------------- --------------------GCUGCCCCAGU-GCCGAAGGGAAGCU-GUUAAGUC----- -------CACC-GCCUGGGAAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-CGCGUGGAGCCUGCGGUUUAAUUGGAUUCAACGCCGGACA-UCUC- A-CCA-GGG-GC-GA-CAGCA-GUA-UGAUGGC-CAGGUUGAUGA--CCUU-G-CCUGA- --------------------CGAG-CUGA-GAGGAGGUGCAUGGCCGCCGUCAGCUCGUA CC-GUGAGGCGUCCUGUUAAGUCAGGCAACGAGCGAGACCCA-CGCCC-UUAGUUACC-A GCGGAACCC--------------------------------------------------- ------------------------------------------------------------ ----------------U-UA--U------------------------------------- ------------------------------------------------------------ -----------------------------------------GG--GUUGC---------- --C-G---------GGCACACUAAGGGGACC-GCCA-G----UGA-UAAAC-UG-GAGGA AGGAGUGGACGACGGUAGGUCCGU-AUGCCCCGA-AUCCCCUGGGCAACACGCGGGCUAC AAUG-GCCUGGACAAUGGGU---------------------------------------- ----------------------U-CCGACACCGAAAGGUGGAGGUAA-UCCC--C-UAAA CCAGGUCGUAGUUCGGAUCGAGGGCUGUAACCCGCCCUCGUG-AAGCUGGAAUGCGUAGU AAUCGCGU-GUCACU-AUCGCGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CACGCCACCCAAA-AAGGGCUU-GGAUGAGGCCACA-ACA-------------------- ----U-UC---------------------------UGUUG----------UGGUCG-AAU CUGGGUUCUUUGAGGAGGGCGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCU------------ >Nanoarchaeum_equitans ----------------ACUCCCGUUGAUCCUG-CGGGAGGCCAC--CGCUAUCUCC-GUC CGGCUAACCCAUGGAAGGCGAGGGUCC-CCG---------------------GG---U-A -------------------------A-GG--GG-GCC-CGCCG-CACGGCUGAGUAACAC GUCGGUAAC-CUACCCUCGGG---------------------ACGGGG-AUAACCC--C- G-GGAAA-CUGGGGCUAAUCCCCGA----------------------------------- ------------------------------------------------------------ ---------UA-GG-GGAUGGGUGC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-G-GCC-CC-AUCCCC-GAGAGGGGCUA--GCGG-----------UAC-- U-U-CCC----------CCGCUAGCCCGCCCGAGGAUGGGCCGGCG-GCCCAUCA-GGUA --GUUGGCGGGGUAAUGGCCCG-CCAAGCCGAAGACGGGU-AGGGGCCGUGAGAGCGG-G AGCCCCCAGAUCGGCACUGAGACAAGGGCCGAGGCCCUACGG-GGCGCACCAGGGGCGAA ACCUCCGCAAUGCGG-GAA----ACCGUGACGGGGGGACGGAGAGU--GCCG------GA GGGCGUUAUGCUCUC-------C-GGCUUUUGGGGAGUG----------------UAA-G U-A-------------------GCUCCCCG-AAUAAGCGGUGGGCAAGAGG-GG-UGGCA GCCGCCGCGGGAACACCCCCACCGCGAGCGGUGGCCGUGAUUAUUGGGCCUAAAGGGGCC GUAGCCGGGCCGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UGUGGCUCCGGUGAAAUCCUCGGGCUCAACC- --------------------------------CGAG-GGCGCGCCGGAGCUACUACCG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GCCUA--GGGACCGGGA G-GGGCCGACCGUA-CUCCCGGGGGAGCGGUGAAAUGCUGUAAUCCCGGGAGGACGACCC GUGGCGAAAGCGGUCGGCCAGAACGGGUCCGACGGUGAGGGCCGAAGGCCGGGGGCUAGA ACGGGAUUAGAGACCCCG-GUAUUCCCGGCUGUCAACGCUGC-GGGCUACCUGCUGGGCG GGC--------------------------------------------------------- ---UACGA---------------------------------------------------- --------------------GCCCGCCCAGU-GGGGUAGGGAAGCC-GUUAAGCC----- -------CGCC-GCCUGGGGAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUAGGCGG GGGAGCA-CACAA-GAGGUGGGGUGCGCGGUUUAAUUGGAUUCGACGCCGGGAA-CCUC- A-CCG-GGG-CU-GA-CAGCA-CAA-UGAUGGU-CGGCCUGAAGG--GCCU-A-CCGGA- --------------------GGCG-CUGA-GAGGAGGUGCAUGGCCGCCGUCAGCCUGUG CC-GUGAGGUGCCCUGUUAAGUCAGGAAACAGGCGAGACCCG-CGCCC-GCAGUUGCG-A CGGCC------------------------------------------------------- ------------------------------------------------------------ ----------------G-AA--A------------------------------------- ------------------------------------------------------------ -----------------------------------------------G-G---------- --C-C---------GGCACACUGCGGGGACU-GCCG-G----GGA--AACC-CG-GAGGA AGGUGCGGGCGACGGCAGGUAUGC-AUGCCCCGA-AUGCCCCGGGCUACACGCGCGCAUC AAUG-GGCGGGACAGGGGGC---------------------------------------- ----------------------C-GCGACCCCGAAAGGGGGAGCAAA-UCCC--C--AAA CCCGCUCUCAGUCCAGAUCGAGGGCUGCAACUCGCCCUCGUG-ACGGCGGAAUCUCUAGU AGUCGGAC-GUCACC-AGCGUCCGGCGAAUACGUCCCUGCUCCUUGCACUCACCGCCCGU CAAGCCACCCGAG-CUGGGGCC-UAGCGAGGCCGUG-GGG----GG-------------- ----U-UC-G----------------------CC-CCCCA----------CGGUCG-AGC UAGGCCCCGGCGAGGGGGGCUAAGUCGACACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCU------------ >Natronomonas_pharaonis -----------------UUCCGGUUGAUCCUG-CCGGAGGCCAU--UGCUAUCGGU-GUC CGAUUUAGCCAUGCGAGUUGUACGU---------------------------UU---A-- ----------------------------------CCG-UAGCA-AACUGCUCAGUAACAC GUGGCCAAA-CUGCCCUAUGG---------------------ACCGGA-AUAACCU--C- G-GGAAA-CUGAGGCUAAUUCCGGA----------------------------------- ------------------------------------------------------------ ---------UA-CC-ACAUUCAUCC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-UUGGA-GA-AUGUGC-GAAA-UGC----------------------U-- C-C-G-------------------GCG-CCAUAGGAUGUGGCUGCG-GCCGAUUA-GGUA --GACGGUGGGGUAACGGCCCA-CCGUGCCGAUAAUCGGU-ACGGGUCAUGAGAGUGA-G AGCCCGGAGACGGACUCUGAGACACGAGUCCGGGCCCUACGG-GGCGCAGCAGGCGCGAA ACCUUUACACUGCAC-GAC----AGUGCGAUAGGGGGACACCGAGU--GCGA------GG GC--AUAGA--GCCC-------U-CGCUUUUCUGAACCG----------------UAA-G G-A-------------------GGUUCAGG-AACAAGGGCUGGGCAAGACC-GG-UGCCA GCCGCCGCGGUAACACCGGCAGCCCAAGUGAUGGCCGAUAUUAUUGGGCCUAAAGCGUCC GUAGCUGGCCGUG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUUCGUCGGGAAAUCCACUCGCUUAACG- --------------------------------AGUG-GGCGUCCGGCGAAAACUGCUC-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUU--GGGACCGGAA G-AUCCAAGGGGUA-CGUCCGGGGUAGGAGUGAAAUCCCGUAAUCCUGGACGGACCACCG AUGGCGAAAGCACCUUGGAAGGACGGAUCCGACAGUGAGGGACGAAAGCUAGGGUCUCGA ACCGGAUUAGAUACCCGG-GUAGUCCUAGCCGUAAACGAUGC-UCGCUAGGUGUGGCGCA GGC--------------------------------------------------------- ---UACGA---------------------------------------------------- --------------------GCCUGCGCUGU-GCCGUAGGGAAGCC-GUGAAGCG----- -------AGCC-GCCUGGGAAGUACGU-CUGCAAGGA-UGAAACUUAAAGGAAUUGGCGG GGGAGCACUACAA-CCGGAGGAGCCUGCGGUUUAAUUGGACUCAACGCCGGACA-UCUC- A-CCA-GCU-CC-GA-CAGCAGUAA-UGACGGU-CAGGUUGAUGA--CCUU-A-CCCGA- --------------------CGCUGCUGA-GAGGAGGUGCAUGGCCGCCGUCAGCUCGUA CC-GUGAGGCGUCCUGUUAAGUCAGGCAACGAGCGAGACCCG-CACCU-CUAGUUGCC-A GCAGCAUC---------------------------------------------------- ------------------------------------------------------------ ----------------U-UG--C------------------------------------- ------------------------------------------------------------ ------------------------------------------G--AUGGC---------- --U-G---------GGUACACUAGGGGGACU-GCCG-U----CGC-UAAGA-CG-GAGGA AGGAACGGGCAACGGUAGGUCAGU-AUGCCCCGA-AUGAGCUGGGCUACACGCGGGCUAC AAUG-GCCAAGACAGUGGGA---------------------------------------- ----------------------U-GCGACACCGAGAGGUGAAGCUAA-UCUC--C-UAAA CUUGGUCGUAGUUCGGAUUGCGGACUGAAACCCGUCCGCAUG-AAGCUGGAUUCGGUAGU AAUCGCGU-GUCAGA-AGCGCGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CAAAGCACCCGAG-UGGGGUCC-GGAUGAGGCCUGG------------------------ ----C-UA------------------------------CC----------AGGUCG-AAU CUGGGCUCCGCAAGGGGGCUUAAGUCGUAACAAGGUAGCCGUAGGGGAAUCUGCGGCUGG AUCACCUCCU------------ >Picrophilus_torridus -------CAUGGAUUAACUCCGGUUGAUCCUG-CCGGCGGCCAC--UGCUAUCAAG-UUC CGACUAAGCCAUGCGAGUCAAGGGGCC-------------------------GU---A-A -------------------------------GG-CAC-CGGCG-UACCGCUCAGUAACAC GCGGAUAAU-CUACCCUCGGG---------------------AAGGGC-AUAACCU--C- G-GGAAA-CUGAGGCUAAUUCCCUA----------------------------------- ------------------------------------------------------------ ---------UA-GC-CAUUCAGAAC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GUU-UG-GAUGGU-GAAG--GC----------------------U-- C-C-G-------------------GC-GCCCGGGGAUGAGUCUGCG-GCCUAUCA-GGUA --GUAGGUGGUGUAACGGACCA-CCUAGCCUAAGACGGGU-ACGGGCCCUGGGAGGGG-U AGCCCGGAGAUGGACUCUGAGACACUAGUCCAGGCCCUACGG-GGCGCAGCAGGCGCGAA ACCUGUGCAAUGCGC-GCA----AGCGCGACACGGGGAGCUUGAGU--GUCU------UG GC--AA-AA--GCCA-------A-GACUUUUCUUAUGCC----------------UAA-A A-A-------------------GCAUAAGG-AAUAAGGGCUGGGUAAGACG-GG-UGCCA GCCGCCGCGGUAACACCCGCAGCUCAAGUGGUGGUCACUUUUACUGAGCCUAAAGCGUUC GUAGCCGGCUUUG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAAUCUCCAGGUAAAUUCUAGCGCUUAACG- --------------------------------UUAG-AUC-UCCUGGAGAGACUGCAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AGCUU--GGGACCGGGU G-GGGUUGAACGUA-CUUUCAGGGUAGGGGUAAAAUCCUGUAAUCCUGGAAGGACGACCG GUAGCGAAGGCGUUCAACUAGAACGGAUCCGACGGUGAGGAACGAAGGCUAGGGGAGCAA ACCGGAUUAGAUACCCGG-GUAGUCCUAGCUGUAAACUCUGC-CCACUUGGUGUUGCCUU UCC--------------------------------------------------------- ---GUUGA---------------------------------------------------- --------------------GGGGAGGCAGU-GCCGGAGCGAAGGU-GUUAAGUG----- -------GGCC-GCUUGGGGAGUAUGG-UCGCAAGAC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCGCAA-CGGGAGGAAUGUGCGGUUUAAUUGGAUUCAACGCCGGAAA-ACUC- A-CCG-GGA-GC-GA-CCUGU-GGA-UGAGAGU-CAACCUGACGA--GUUU-A-CUCGA- --------------------UAGC-AGGA-GAGGUGGUGCAUGGCCGUCGUCAGCUCGUA CC-GUAGGGCGUUCACUUAAGUGUGAUAACGAGCGAGACCCC-CAUCU-CCAAUUGCA-A UUACCUAC---------------------------------------------------- ------------------------------------------------------------ ----------------G-CG--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--UAG-G---------- --U-A---------AGCACUUUGGAGAGACC-GCCA-G----CGC-UAAGC-UG-GAGGA AGGAGGGGUCGACGGCAGGUCAGU-ACGCCCCGA-AUCUCCCGGGCUACACGCGCAUUAC AAAG-GGCAGGACAAUGCGU---------------------------------------- ----------------------U-GCAACCUCGAAAGGGGAAGCUAA-UCGC--C--AAA CCUGUCCGUAGUUAGGAUUGAGGGCUGUAACUCGCCCUCAUG-AAUCUGGAUUCCGUAGU AAUCGCGG-GUCAAC-AACCCGCGGUGAAUAUGCCCCUGCUCCUUGCACACACCGCCUGU CAAACCAUCCGAG-CUGGUGUU-GGAUGAGGGUUAG-CUC-------------------- ----G-AG-A-------------------------GGGUU----------AGCUCA-AAU CUGAUGUCAGUGAGGAGGGUUAAGUCAUAACAAGGUAUCUGUAGGGGAACCUGCAGAUG- ---------------------- >Pyrobaculum_calidifontis -------------------CCGGUUGAUCCUG-CCGGACCCGAC--CGCUAUCGGG-GUA GGGCUAAGCCAUGCGAGUCGCGCGCCC-GGG---------------------GG---C-G -------------------------C-CC--GG-GAG-CGGCG-CACGGCUCAGUAACAC GUGCCUAAC-CUAACCUCGGG---------------------AGGGGG-ACACCCC--C- G-GGAAA-CUGGGGUCAAUCCCCCA----------------------------------- ------------------------------------------------------------ ---------UA-GG-GGAAGGGCGC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-G-GCC-CC-UUCCCC-GAAAGGGCUGG--CGGC------------CG-- A-U-CCG-----------CCGCCAGUCGCCCGAGGGUGGGGGCACG-GCCCAUCA-GGUA --GUUGGCGGGUUAAAGGCCCG-CCAAGCCGAAGACGGGU-AGGGGCGGUGAGAGCCGCG AGCCCCGAGAUGGGCACUGAGACAAGGGCCCAGGCCCUACGG-GGUGCAGCAGGCGCGAA UACUCCGCAAUGCGG-GCA----ACCGCGACGGGGCUACCCCGAGU--GCCG------GG CG--AA--G--AGCC-------C-GGCUUUUGCCCGGUC----------------UAA-A A-A-------------------GCCGGGAG-AAUAAGCGGGGGGCAAGUCU-GG-UGUCA GCCGCCGCGGUAAUACCAGCUCCGCGAGUGGUCGGGGUGUUUACUGGGCUUAAAGCGCCC GUAGCCGGCCCGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUCGCUCCUGAAAUCCCCGGGCUCAACC- --------------------------------CGGG-GGC-CGGGGGCGAUACUGCCG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GGGGGCGGGA G-AGGCCGCCGGUA-CUCCGGGGGUAGGGGCGAAAUCCGUUAAUCCCCGGAGGACCACCA GUGGCGAAAGCGGGCGGCCAGAACGCGCCCGACGGUGAGGGGCGAAAGCCGGGGGAGCAA AGGGGAUUAGAUACCCCU-GUAGUCCCGGCCGUAAACGAUGC-GGGCUAGCUGUCGGUCG GGC--------------------------------------------------------- ---UUAGG---------------------------------------------------- --------------------GCCCGGCCGGU-GGCGAAGGGAAACC-GUUAAGCC----- -------CGCC-GCCUGGGGAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGGGCACCACAA-GGGGUGAAGCUUGCGGCUUAAUUGGAGUCAACGCCGGAAA-CCUC- A-CCC-GGG-GC-GA-CAGCA-GGA-UGAAGGC-CAGGCUAACGA--CCUU-G-CCGGA- --------------------CGAG-CUGA-GAGGAGGUGCAUGGCCGUCGUCAGCUCGUG CC-GUGAGGUGUCCGGUUAAGUCCGGCAACGAGCGAGACCCC-CGCCC-CUAGUUGCU-A CCCCUCCC---------------------------------------------------- ------------------------------------------------------------ ----------------U-AC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--GGAGG---------- --G-G---------GGCACACUAGGGGGACU-GCCG-G----CG--UAAGC-CG-GAGGA AGGAGGGGGCCACGGCAGGUCAGU-AUGCCCCGA-AACCCCGGGGCUGCACGCGAGCUGC AAUG-GCGGGGACAGCGGGA---------------------------------------- ----------------------U-CCGACCCCGAAAGGGGGAGGCAA-UCCC--G-UAAA CCCCGCCCCAGUAGGGAUCGAGGGCUGCAACUCGCCCUCGUG-AACGUGGAAUCCCUAGU AACCGCGU-GUCACC-AACGCGCGGUGAAUACGUCCCUGCCCCUUGCACACACCGCCCGU CGCACCACCCGAG-GGAGCCCU-CUGCGAGGCCCCU-CGCC------------------- ----G-CA-A------------------------GGUGGG----------GGGACG-AGC AGGGGGCUCCCAAGGGGGGUGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCC------------- >Pyrococcus_furiosus ----------------AUUCCGGUUGAUCCUG-CCGGAGGCCAC--UGCUAUGGGG-GUC CGACUAAGCCAUGCGAGUCAAGGGGGC-GUC------------C-C------UU---C-U -------G-G---------------G-AC--GC-CAC-CGGCG-GACGGCUCAGUAACAC GUCGGUAAC-CUACCCUCGGG---------------------AGGGGG-AUAACCC--C- G-GGAAA-CUGGGGCUAAUCCCCCA----------------------------------- ------------------------------------------------------------ ---------UA-GG-CCUGGGGUAC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-G-GUC-CC-CAGGCC-GAAAGGGAGCC-------------------G-- U-A-A----------------GGC-CCGCCCGAGGAUGCGGCGGCG-GCCGAUUA-GGUA --GUUGGUGGGGUAACGGCCCA-CCAAGCCGAAGAUCGGU-ACGGGCCGUGAGAGCGG-G AGCCCGGAGAUGGACACUGAGACACGGGUCCAGGCCCUACGG-GGCGCAGCAGGCGCGAA ACCUCCGCAAUGCGG-GAA----ACCGCGACGGGGGGACCCCCAGU--GCCG------UG CC--UC--U--GGCA-------C-GGCUUUUCCGGAGUG----------------UAA-A A-A-------------------GCUCCGGG-AAUAAGGGCUGGGCAAGGCC-GG-UGGCA GCCGCCGCGGUAAUACCGGCGGCCCGAGUGGUGGCCACUAUUAUUGGGCCUAAAGCGGCC GUAGCCGGGCCCG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCCCUGGCGAAAUCCCACGGCUCAACC- --------------------------------GUGG-GGCUCGCUGGGGAUACUGCGG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GCCUU--GGGACCGGGA G-AGGCCGGGGGUA-CCCCCGGGGUAGGGGUGAAAUCCUAUAAUCCCGGGGGGACCGCCA GUGGCGAAGGCGCCCGGCUGGAACGGGUCCGACGGUGAGCGCGGAAGGCCAGGGGAGCGA ACCGGAUUAGAUACCCGG-GUAGUCCUGGCUGUAAAGGAUGC-GGGCUAGGUGUCGGGCG AGC--------------------------------------------------------- ---UUCGA---------------------------------------------------- --------------------GCUCGCCCGGU-GCCGUAGGGAAGCC-GUUAAGCC----- -------CGCC-GCCUGGGGAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACUACAA-GGGGUGGAGCGUGCGGUUUAAUUGGAUUCAACGCCGGGAA-CCUC- A-CCG-GGG-GC-GA-CGGCA-GGA-UGAAGGC-CAGGCUGAAGG--UCUU-G-CCGGA- --------------------CGCG-CCGA-GAGGAGGUGCAUGGCCGCCGUCAGCUCGUA CC-GUGAGGCGUCCACUUAAGUGUGGUAACGAGCGAGACCCG-CGCCC-CCAGUUGCC-A GUCCCUCCC--------------------------------------------------- ------------------------------------------------------------ ----------------G-CU--C------------------------------------- ------------------------------------------------------------ -----------------------------------------GG--GA--G---------- --G-A---------GGCACUCUGGGGGGACU-GCCG-G----CGA-UAAGC-CG-GAGGA AGGGGCGGGCGACGGUAGGUCAGU-AUGCCCCGA-AACCCCCGGGCUACACGCGCGCUAC AAUG-GGCGGGACAAUGGGA---------------------------------------- ----------------------C-CCGACCUCGAAAGGGGAAGGGAA-UCCC--C-UAAA CCCGCCCUCAGUUCGGAUCGCGGGCUGCAACUCGCCCGCGUG-AAGCUGGAAUCCCUAGU ACCCGCGU-GUCAUC-AUCGCGCGGCGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CACUCCACCCGAG-CGGAGUCC-GGGUGAGGCCUGA-UCUCC------------------ ----U-UC-G-----------------------GGAGGUC----------AGGUCG-AGC CCGGGCUCCGUGAGGGGGGAGAAGUCGUAACAAGGUAACCGUAGGGGAACCUACGGCUCG AUCACCUCCU------------ >Staphylothermus_marinus ----------------ACUCCGGUUGAUCCUG-CCGGACCCGAC--CGCUAUCGGG-GUG GGGCUAAGCCAUGGGAGUCGUACGCUC-CGC---------------------CG---C-U -------------------------G-CG--GA-GCG-UGGCG-GACGGCUGAGUAACAC GUGGCUAAC-CUACCCUCGGG---------------------AGGGGG-AUAACAC--C- G-GGAAA-CUGGUGCUAAUCCCCCA----------------------------------- ------------------------------------------------------------ ---------UA-GG-GGAGGAUGCC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-G-GGU-UC-CUCCCC-GAAAGGGUGCG--GUGG-----------GGG-- U-UAUCG----------CCGCCGCGCCGCCCGAGGAUGGGGCUGCG-GCCCAUCA-GGUA --GUUGGCGGGGUAACGGCCCG-CCAAGCCGAUAACGGGU-AGGGGCCGUGAGAGCGG-G AGCCCCCAGAUGGGCACUGAGACAAGGGCCCAGGC-CUACGG-GGUGCACCAGGCGCGAA ACCUCCGCAAUGCGG-GCA----ACCGUGACGGGGUCACCCCGAGU--GCCC------CC ----UAUAU----GG-------G-GGCUUUUCCCCGCUG----------------UAG-G A-A-------------------GGCGGGGG-AAUAAGCGGGGGGCAAGUCU-GG-UGUCA GCCGCCGCGGUAAUACCAGCCCCGCGAGUGGUCGGGACGAUUAUUGGGCCUAAAGCGCCC GUAGCCGGCCUGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUCCCCUCCUAAAUCCCCGGGCUCAACC- --------------------------------CGGG-GAG-UGGAGGGGAAACUGCCA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GGGGGCGGGA G-AGGCCGAGGGUA-CUCCCGGGGUAGGGGCGAAAUCCUAUAAUCCCGGGAGGACCACCA GUGGCGAAGGCGCUCGGCUGGAACGCGCCCGACGGUGAGGGGCGAAAGCCGGGGGAGCGA ACCGGAUUAGAUACCCGG-GUAGUCCCGGCUGUAAACGAUGC-GGGCUAGGUGUUGGGCG GGC--------------------------------------------------------- ---UUAGA---------------------------------------------------- --------------------GCCCGCCCAGU-GCCGCAGGGAAGCC-GUUAAGCC----- -------CGCC-GCCUGGGGAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-GGGGUGGAGCCUGCGGUUUAAUUGGAGUCAACGCCGGGAA-CCUC- A-CCG-GGG-GC-GA-CAGCA-GGA-UGACGGC-CAGGCUAACGG--CCUU-G-CCCGA- --------------------CGCG-CUGA-GAGGAGGUGCAUGGCCGUCGCCAGCUCGUG CC-GUGAGGUGUCCGGUUAAGUCCGGCAACGAGCGAGACCCC-CGCCC-CUAGUUGCG-A CCCGGAGC---------------------------------------------------- ------------------------------------------------------------ ----------------U-CU--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--CUC-C---------- --G-G---------GGCACACUAGGGGGACU-GCCG-C----CGUAUAAGG-CG-GAGGA AGGAGGGGGCCACGGCAGGUCAGC-AUGCCCCGA-AUCCCCCGGGCUACACGCGGGCUAC AAUG-GCGGGGACAGCGGGA---------------------------------------- ----------------------U-CCGACCCCGUAAGGGGGAGGCAA-UCCC--U-CAAA CCCCGCCGCAGUUGGGAUCGAGGGCUGCAACUCGCCCUCGUG-AACGUGGAAUCCCUAGU AACCGCGC-GUCAUC-AUCGCGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CGCUCCACCCGAG-GGAGGGGGUGAGUGAGGCCCGG-UCCCCCGGG-------------- ----N-AA-A-------------------CCCGGGGGNCG----------GGGUCG-AAC UCUCCCCUCCCAAGGGGGGAGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUCCC------------ >Sulfolobus_acidocaldarius ----------------AUUCCGGUUGAUCCUG-CCGGACCCGAC--CGCUAUCGGG-GUA GGGAUAAGCCAUGGGAGUCUUACACUC-CCG---------------------GG---U-A -------------------------A-GG--GA-GUG-UGGCG-GACGGCUGAGUAACAC GUGGCUAAC-CUACCCUCGGG---------------------ACGGGG-AUAACCC--C- G-GGAAA-CUGGGGAUAAUCCCCGA----------------------------------- ------------------------------------------------------------ ---------UA-GG-GAAGGAGUCC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GGU-UC-CUUCCC-UAAAGGGCUAU--AGGC-----------UAU-- U-U-CCC----------GUUUGUAGCCGCCCGAGGAUGGGGCUACG-GCCCAUCA-GGCU --GUCGGUGGGGUAAAGGCCCA-CCGAACCUAUAACGGGU-AGGGGCCGUGGAAGCGG-G AGCCUCCAGUUGGGCACUGAGACAAGGGCCCAGGCCCUACGG-GGCGCACCAGGCGCGAA ACGUCCCCAAUGCGC-GAA----AGCGUGAGGGCGCUACCCCGAGU--GCCU------CC ----GC-AA----GG-------A-GGCUUUUCCCCGCUC----------------UAA-A A-A-------------------GGCGGGGG-AAUAAGCGGGGGGCAAGUCU-GG-UGUCA GCCGCCGCGGUAAUACCAGCUCCGCGAGUGGUCGGGGUGAUUACUGGGCCUAAAGCGCCU GUAGCCGGCCCAC----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAAGUCGCCCCUUAAAGUCCCCGGCUCAACC- --------------------------------GGGG-AAC-UGGGGGCGAUACUGGUG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GGGGGCGGGA G-AGGCGGGGGGUA-CUCCCGGAGUAGGGGCGAAAUCCUUAGAUACCGGGAGGACCACCA GUGGCGGAAGCGCCCCGCUAGAACGCGCCCGACGGUGAGAGGCGAAAGCCGGGGCAGCAA ACGGGAUUAGAUACCCCG-GUAGUCCCGGCUGUAAACGAUGC-GGGCUAGGUGUCGAGUA GGC--------------------------------------------------------- ---UUAGA---------------------------------------------------- --------------------GCCUACUCGGU-GCCGCAGGGAAGCC-GUUAAGCC----- -------CGCC-GCCUGGGGAGUACGG-UCGCAAGAC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-GGGGUGGAACCUGCGGCUCAAUUGGAGUCAACGCCUGGAA-UCUU- A-CCG-GGG-GA-GA-CCGCA-GUA-UGACGGC-CAGGCUAACGA--CCUU-G-CCUGA- --------------------CUCG-CGGA-GAGGAGGUGCAUGGCCGUCGCCAGCUCGUG UU-GUGAAAUGUCCGGUUAAGUCCGGCAACGAGCGAGACCCC-CACCC-CUAGUUGGU-A UUCUGGAC---------------------------------------------------- ------------------------------------------------------------ ----------------U-CC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--UCC-A---------- --G-A---------ACCACACUAGGGGGACU-GCCG-G----CG--UAAGC-CG-GAGGA AGGAGGGGGCCACGGCAGGUCAGC-AUGCCCCGA-AACUCCCGGGCCGCACGCGGGUUAC AAUG-GCAGGGACAACGGGA---------------------------------------- ----------------------U-GCUACCUCGAAAGGGGGAGCCAA-UCCU----UAAA CCCUGCCGCAGUUGGGAUCGAGGGCUGAAACCCGCCCUCGUG-AACGAGGAAUCCCUAGU AACCGCGG-GUCAAC-AACCCGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CGCUCCACCCGAG-CGAGAAAG-GGGUGAGGUCCCU-UGCG------------------- ----A-U--A------------------------AGUGGG----------GGAUCG-AAC UCCUUUCCCGCGAGGGGGGAGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCAC----------------- >Sulfolobus_tokodaii ----------------AUUCCGGUUGAUCCUG-CCGGACCCGAC--CGCUAUCGGG-GUA GCACUAAGCCAUGGGAGUCGUACACCC-CCG---------------------GG---C-A -------------------------A-GG--GG-GUG-UGGCG-GACGGCUGAGUAACAC GUGGCUAAC-CUACCCUCGGG---------------------AGGGGG-AUAACCC--C- G-GGAAA-CUGGGGAUAAUCCCCCA----------------------------------- ------------------------------------------------------------ ---------UA-GG-GGAGGAGUCC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-C-GGU-UC-CUCCCU-UAAAAGGGUAU--GGGC-----------UAU-- U-U-CCC----------GCUCAUACCCGCCCGAGGAUGGGGCUGCG-GCCCAUCA-GGCU --GUUGGCGGGGUAACGGCCCG-CCAAACCUAUAACGGGU-AGGGGCCGUGGGAGCGG-G AGCCCCCAGUUGGGCACUGAGACAAGGGCCCAGGCCCUACGG-GGCGCACCAGGCGGGAA ACGUCCCCAAUGCGC-GAA----AGCGUGAGGGCGCUACCCCGAGU--GCCC------CC ----GU-AA----GG-------G-GGCUUUUCCCCGCUC----------------UAC-A A-A-------------------GGCGGGGG-AAUAAGCGGGGGGCAAGUCU-GG-UGUCA GCCGCCGCGGUAACACCAGCUCCGCGAGUGGUCGGGACGCUUACUGGGCCUAAAGCGCCU GUAGCCGGCCCAC----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCGCCCCUUAAAGACCCGGGCUCAACC- --------------------------------CGGG-AAA-UGGGGGCGAUACUGGUG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GGGGGCGGGA G-AGGCUAGGGGUA-CUCCCAGAGGAGGGGCGAAAUCCGUAGAUCCUGGGAGGACCACCA GUGGCGGAGGCGCCUAGCUAGAACGCGCCCGACGGUGAGAGGCGAAAGCCGGGGCAGCAA AUGGGAUUAGAUACCCCA-GUAGUCCCGGCUGUAAACGAUGC-GGGCUAGGUGUCAGGUG GGC--------------------------------------------------------- ---UUAGA---------------------------------------------------- --------------------GCUCACCUGGU-GCCGCAGGGAAGCC-GUUAAGCC----- -------CGCC-GCCUGGGGAGUACGG-UCGCAAGAC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-GGGGUGGAACCUGCGGCUCAAUUGGAGUCAACGCCUGGAA-UCUU- A-CCG-GGG-GA-GA-CCGCA-GGA-UGACGGC-CAGGCUAACGA--CCUU-G-CCUGA- --------------------CUCG-CGGA-GAGGAGGUGCAUGGCCGUCGCCAGCUCGUG UU-GUGAAAUGUCCUGUUAAGUCAGGCAACGAGCGAGACCCC-CACCC-CUAGUUGGU-A UCCCCAUC---------------------------------------------------- ------------------------------------------------------------ ----------------U-CC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--AUG-G---------- --G-G---------GCCACACUAGGGGGACU-GCCG-C----CG--UAAGG-CG-GAGGA AGGAGGGGGCCACGGCAGGUCAGC-AUGCCCCGA-AACCCCCGGGCCGCACGCGGGUUAC AAUG-GCAGGGACAGCGGGA---------------------------------------- ----------------------UUGCGACCCCGAAAGGGGGAGCCAA-UCCC--C-CAAA CCCUGCCGCAGUUGGGAUCGAGGGCUGAAACCCGCCCUCGUG-AACGAGGAAUCCCUAGU AACCGCGG-GUCAAC-AACCCGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CGCUCCACCCGAG-AGAGGAAG-GGGUGAGGUCCCC-UGCG------------------- ----A-U--G------------------------AGUGGG----------GGAUCG-AAC UCCUUCCUCUCGAGGGGGGAGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUGCGGCUGG AUCACCUC-------------- >Thermococcus_kodakarensis ----------------AUUCCGGUUGAUCCUG-CCGGAGGCCAC--UGCUAUGGGG-GUC CGACUAAGCCAUGCGAGUCAUGGGGCG-CGC---------------------UC---U-G ---------------------------CG--CG-CAC-CGGCG-GACGGCUCAGUAACAC GUCGGUAAC-CUACCCUCGGG---------------------AGGGGG-AUAACCC--C- G-GGAAA-CUGGGGCUAAUCCCCCA----------------------------------- ------------------------------------------------------------ ---------UA-GG-CCUGAGGUAC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-G-GUC-CU-CAGGCC-GAAAGGGGC---------------------A-- U-C-U------------------GCCCGCCCGAGGAUGGGCCGGCG-GCCGAUUA-GGUA --GUUGGUGGGGUAACGGCCCA-CCAAGCCGAAGAUCGGU-ACGGGCCAUGAGAGUGG-G AGCCCGGAGAUGGACACUGAGACACGGGUCCAGGCCCUACGG-GGCGCAGCAGGCGCGAA ACCUCCGCAAUGCGG-GCA----ACCGCGACGGGGGGACCCCCAGU--GCCG------UG GC--AU--A--GCCA-------C-GGCUUUUCCGGAGUG----------------UAA-A A-A-------------------GCUCCGGG-AAUAAGGGCUGGGCAAGGCC-GG-UGGCA GCCGCCGCGGUAAUACCGGCGGCCCGAGUGGUGGCCGCUAUUAUUGGGCCUAAAGCGUCC GUAGCCGGGCCCG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCCCUGGCGAAAUCCCACGGCUCAACC- --------------------------------GUGG-GGCUUGCUGGGGAUACUGCGG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GCCUU--GGGACCGGGA G-AGGCCGGGGGUA-CCCCUGGGGUAGGGGUGAAAUCCUAUAAUCCCAGGGGGACCGCCA GUGGCGAAGGCGCCCGGCUGGAACGGGUCCGACGGUGAGGGACGAAGGCCAGGGGAGCGA ACCGGAUUAGAUACCCGG-GUAGUCCUGGCUGUAAAGGAUGC-GGGCUAGGUGUCGGGCG AGC--------------------------------------------------------- ---UUCGA---------------------------------------------------- --------------------GCUCGCCCGGU-GCCGGAGGGAAGCC-GUUAAGCC----- -------CGCC-GCCUGGGGAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACUACAA-GGGGUGGAGCGUGCGGUUUAAUUGGAUUCAACGCCGGGAA-CCUC- A-CCG-GGG-GC-GA-CGGCA-GGA-UGAAGGC-CAGGCUGAAGG--UCUU-G-CCGGA- --------------------CACG-CCGA-GAGGAGGUGCAUGGCCGCCGUCAGCUCGUA CC-GUGAGGCGUCCACUUAAGUGUGGUAACGAGCGAGACCCG-CGCCC-CCAGUUGCC-A GUCCUCCCC--------------------------------------------------- ------------------------------------------------------------ ----------------G-CU---------------------------------------- ------------------------------------------------------------ -----------------------------------------GG--GGA-G---------- --G-A---------GGCACUCUGGGGGGACC-GCCG-G----CGA-UAAGC-CG-GAGGA AGGAGCGGGCGACGGUAGGUCAGU-AUGCCCCGA-AACCCCCGGGCUACACGCGCGCUAC AAUG-GGCGGGACAAUGGGA---------------------------------------- ----------------------U-CCGACCCCGAAAGGGGAAGGGAA-UCCC--C-UAAA CCCGCCCUCAGUUCGGAUCGCGGGCUGCAACUCGCCCGCGUG-AAGCUGGAAUCCCUAGU ACCCGCGU-GUCAUC-AUCGCGCGGCGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CACUCCACCCGAG-CGGGGUCC-GGGUGAGGCCUGG-UCUCC---C-------------- ----U-UC-G----------------------GGGAGGCC----------GGGUCG-AGC CUGGGCUCCGUGAGGGGGGAGAAGUCGUAACAAGGUAGCCGUAGGGGAACCUACGGCUCG AUCACCUCCUAUCGCCGGA--- >Thermofilum_pendens ------------------UCCGGUUGAUCCUG-CCGGACCCGAC--CGCUAUCGGG-GUG GGGCUAACCCAUGGAAGUCUAGGAGCC-GGG---------------------GC---U-A --C----G-G-----------------CC--GG-CUC-CGGCG-GACGGCUCAGUAGCAC GUGGCUAAC-CUACCCUCGGG---------------------AGGGGG-AUAACCC--C- G-GGAAA-CUGGGGAUAAACCCCCA----------------------------------- ------------------------------------------------------------ ---------UA-GG-CGCGGACACC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-U-GGG-UC-CGCGCU-GAAAGGGCCAC--GGUA------------CC-- A-U-GCU----------UACCGUGGCCGCCCGAGGAUGGGGCUGCG-CCCUAUCA-GGUA --GUUGGCGGGGUAACGGCCCG-CCAAGCCGAUAACGGGU-GGGGGCCGUGAGAGCGG-G AGCCCCGAGAUGGGCACUGAGACAAGGGCCCAGGCCCUACGG-GGUGCACCAGGGGCGAA ACUUCCGCAAUGCGG-GAA----ACCGUGACGGAGUCACCCCGAGU--GCCA------CC CG--AA--G--AGGG-------U-GGCUUUUGCCCGGUC----------------UAA-A A-A-------------------GCCGGGCG-AAUAAGCGGGGGGCAAGCUU-GG-UGUCA GCCGCCGCGGUAAUACCAACCCCGCGAGUGGUCGGGACGUUUAUUGGGCCUAAAGCGUCC GUAGCCGGCCCGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAGUCCCUCCUUAAAGCCCACGGCUCAACC- --------------------------------GUGG-GA-GC-GGAGGGAUACUGCCG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGCUA--GGGGGCGGGA G-AGGCCGGGGGUA-CUCCUGGGGUAGGGGCGAAAUCCUAUAAUCCCAGGAGGACCACCA GUGGCGAAGGCGCCCGGCUAGCACGCGCCCGACGGUGAGGGACGAAAGCUGGGGGAGCAA AGGGGAUUAGAUACCCCC-GUAGUCCCAGCUGUAAACGAUGC-GGGCUAGGUGUUGGACG GGC--------------------------------------------------------- ---UUCGA---------------------------------------------------- --------------------GCCCGUCCAGU-GCCGUAGGGAAGCC-GUUAAGCC----- -------CGCC-GCCUGGGGAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCACAA-GGGGUGAAGCUUGCGGUUUAAUUGGAGUCAACGCCGGAAA-CCUU- A-CCG-GGG-GC-GA-CAGCA-GGA-UGAAGGC-CAGGCUGACGA--CCUU-G-CCAGA- --------------------CGAG-CUGA-GAGGAGGUGCAUGGCCGUCGCCGGCUCGUG CC-GUGAGGUGUCCUGUUAAGUCAGGGAACGAGCGAGACCCC-CGCCC-CUAGUUGCU-A CCCAGCCC---------------------------------------------------- ------------------------------------------------------------ ----------------U-UC--G------------------------------------- ------------------------------------------------------------ ------------------------------------------G--GGC-U---------- --G-G---------GGCACUCUAGGGGGACU-GCCG-G----CGA-UAAGC-CG-GAGGA AGGUGGGGGCUACGGCAGGUCAGU-AUGCCCCGA-AACCCCCGGGCUACACGCGAGCUGC AAUG-GCGGGGACAGCGGGU---------------------------------------- ----------------------U-CCGACCCCGAAAGGGGGAGGUAA-UCCC--U-UAAA CCCCGCCUCAGUAGGAAUCGAGGGCUGCAACUCGCCCUCGUG-AACGUGGAAUCCCUAGU AACCGCGU-GUCACC-AACGCGCGGUGAAUACGUCCCUGCUCCUUGCACACACCGCCCGU CGCUCCACCCGAG-GGAGGCCU-AGGUGAGGCCUCC-UGCC------------------- ----GACG-A-------------------------GGUGG----------GAGGUCGAAC CUGGGCCUCCCAAGGGGGGAGAAGUCGUAACAAGGUGGCCGUAGGGGAACCUGCGGCCGG AUCACCUCCUUU---------- >Thermoplasma_volcanium -------------UUAACUCCGGUCGAUCCUG-CCGGCGGUCAC--UGCUAUCAGG-UUC CGACUAAGCCAUGCAAGUCACGGGGCC-------------------------GU---A-A -------------------------------GG-CAC-CGGCG-AACAGCUCAGUAACAC GUGGAUAAU-UUACCCUCAGG---------------------UGGGGU-AUAACCU--C- G-GGAAA-CUGAGGCUAAUCCCCCA----------------------------------- ------------------------------------------------------------ ---------UA-GU-CAUUACAAAC----------------------------------- ------------------------------------------------------------ ---UG-GA-A-C-GUU-GU-AAUGAU-GAAA--GC----------------------U-- C-C--G------------------GC-GCCUGAGGAUAAGUCUGCG-GCCUAUCA-GGUA --GUAGGUGGUGUAAAGGACCA-CCUAGCCUAAGACGGGU-ACGGGCCCUGAAAGGGG-G AGCCCGGAGAUGGACUCUGAGACAACAGUCCAGGCCCUACGG-GGCGCAGCAGGCGCGAA AACUGUGCAAUGCGC-GAA----AGCGCGACACGGGGAACCUGAGU--GCCU------UG AC--UUUUC--GUCA-------A-GGCUUUUCUGAUGCC----------------UAA-A A-A-------------------GCAUCAGG-AAUAAGGGCUGGGCAAGACG-GG-UGCCA GCCGCCGCGGUAACACCCGCAGCUCGAGUGGUGAUCACUUUUAUUGAGUCUAAAGCGUCC GUAACCGGUCUUA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAAAUCUUCAGAUAAAUUCUCCCGCUUAACG- --------------------------------GAAG-AACUU-CUGAAGAGACUGUAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GACUU--GGGACCGGGU G-AGGUUGAAUGUA-CUUUCAGGGUAGGGGUAAAAUCCUGUAAUCCUGAAAGGACGACCG GUGGCGAAAGCGUUCAACUAGAACGGAUCCGACGGUGAGGGACGAAGGCUAGGGGAGCAA ACCGGAUUAGAUACCCGG-GUAGUCCUAGCUGUAAACGCUGC-CCACUUGGUGUUGCUUC UCC--------------------------------------------------------- ---GUUGA---------------------------------------------------- --------------------GGGGGAGCAGU-GCCGUAGCGAAGGU-GUUAAGUG----- -------GGUC-ACUUGGGGAGUACGG-CCGCAAGGC-UGAAACUUAAAGGAAUUGGCGG GGGAGCACCGCAA-CGGGAGGAGCGUGCGGUUUAAUUGGAUUCAACGCCGGAAA-ACUC- A-CCG-GGA-GC-GA-CCUUC-GGA-UGAGGGU-CAACCUGACGA--AUUU-A-CCCGA- --------------------UAGA-AGGA-GAGGUGGUGCAUGGCCGUCGUCAGCUCGUA CC-GUAGGGCGUUCACUUAAGUGUGAUAACGAGCAAGACCCC-CAUCU-CUAAUUGCU-A AGCUUUCU---------------------------------------------------- ------------------------------------------------------------ ----------------U-AG--C------------------------------------- ------------------------------------------------------------ ------------------------------------------G--GGA-A---------- --G-C---------UGCACUUUAGAGGGACC-GCCA-G----CGC-UAAGC-UG-GAGGA AGGAGGGGUCGACGGCAGGUCAGU-ACGCCCCGA-AUCUCCCGGGCUACACGCGCGCUAC AAAG-GACGGGACAAUGAGU---------------------------------------- ----------------------U-GCAACCUCGAAAGGGGAAGCUAA-CCUC--G--AAA CCCGUUCGUAGUCAGGACUGAGGGCUGUAACUCGCCCUCACG-AAUGUGGAUUCCGUAGU AAUCGUAG-GUCAAC-AGCCUACGGUGAAUAUGCCCCUGCUCCUUGCACACACCGCCCGU CAAACCAUCCGAG-CUGGUGUU-GGAUGAGGGUCUG-UCC-------------------- ----A-UU----------------------------GGAU----------GGAUUCGAAU CUGAUGUCAGUGAGGAGGGUUAAGUCGUAACAAGGUAUCCGUAGGGGAACCUGCGGAUGG AUCACCUCCA------------ >Adineta_vaga -----------------------UUGAUCUUG-UCGGUGG-CUU-UCCUUUGUCUU-G-A AGAUUAAGCCAUGCAUGUCUAAGUAUGAACUGGU------------------UU---A-A -------------------------G-GU--GA-AAC-U-GCG-UACGGCUCAUUACAUC AGCUAUAACUUUCUUUGAUC-AUAAAUUCU-----------AAAUGGA-AUAACCG--A- G-GAAAAGCCUGGGCUAAUACAUGCGA------------CA---------------A--- --------------------UUC-----------------CGGU---AGU--------AA UAUCGGAAU---GCUUUUAUUAGAUC---AAAAC-C------------------------ ------------------UUCUAG--UUCUUUAACCGG-----------AACUG-UUUGU U-GGU-GA-CUCUAAAUAACUUUGUGUUGA--UCGUAUG-AC---------------C-U UUG-U--------------GUCGACGACAUAUCUUUCAAGUGUCUG-ACUUAUCA-ACUU UAGACGGUACAUUAUAUGUCUA-CCGUGGUUGUAACGAGU-ACAGAGAAUCAGGGUUU-G GUUCUGGAGAGGCCGCCUGAGAAACGGCGACCACUUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCACUCUCA--AA----ACGAGGAGGUAGUGAAGAGAAAUAACGAUGUUAG-UC UU--AU-UU---AGG-CU-GACAAUCGGAAUGGGAACACUG--------------UAA-A C-A-----------------GGUUAUCGAUUAACAAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAAGGAAAACUAAAGUUGCUGUGUUUAAAAAGCUC GUAGUUGAAUUUCGGGUAUU-UGUU-G-C-UAG-CUGGUC-------------------- ---------------------------------UAACUG----GCCAUGUUGGUUAACAG AUCCUCAUU---------------UGCUGGACG-----GCU------------------- ------------------------------------------------------------ --------------------------GGCGA-UGAUC-UUUAUC-GAUU--GUCGUCA-- -----GU----------UGCCAG-AACG-UUUACUUUGAGAAAAUUAGAGUGCUAAAAGC AGGC---------UUUC------G-C--C---UAUA-UAU-AUUGCAUGGAAUAAUGAAA UAAGA----------UC-U--CGAUUUU--A-UU-UC-GUU-GGUU-----UUAGAA-AU --U-GAG-AUA------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAU-AGGAUCAGAG G-GGGGCGUACGUA-CUGUGGUGUGAGAGGUGAAAUUCUUGGAUCGCCACAGGACGAACA GCAGCGAAGGCGUUCGCCAAGAAUGUUUUCAUUAAUCAAGAACGAAAGUUUGAGGUUCGA AGACGAUUAGAUACCGUC-CUAGUUCAAACCAUAAACGUUGC-CAACUGUCUUUUAGAUG CGGUU------------------------------------------------------- -AUUUAUAU--------------------------------------------------- -------------------GACUCAUCUGGCGGAUCUCGAGAAAUC-U--AAGUU----- ---UUUAGGUU-CCGGGGGAAGUAUGG-UUGCAAAGC-UGAAACUUAAAAGAAUUGACGG AAGGACA-CACAA-GAAGUGGAGCCUGUGGCCUAAUUUGACUCAACACGGGAAA-CCUU- A-CUC-GGC-CA-GGACACUU-UUA-GGAUUGA-CAGAUUGAGAGC-UCUU-U-CUUGA- --------------------UUAG-GUGG-GUGGUGGUGCAUGGUCGUUCGUAGUUCGUG GA-GCGAUUUGUCUGAUUAAUUUCGAUAACGAACGAGACUCC-GGCUUACUAAAUAGU-C UAAAG------------------------------------------------------- ------------------------------------------------------------ ------------------UU---------------------------------------- ------------------------------------------------------------ --------------------------------------CGAAGGG-AC-UU--------- --U-U------CAAGACUUCUUAGCAGGAUA-AGUG-GCACUUUU-UAAGC-CA-CACGA A--AUGGAGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUCCGAGGCUGCACGCGCGCUAC ACUG-GAGAGUUCAGAAUGU-------------------------------UUC------ ----------------------UUCCUACUUCGACAGAAGUGGGUAA-CCAU--GAAAUU CUC-UUCGUGACUGGGAUCGGAGCUUGCAAUUAUUCUCCGUC-AACGAGGAAUUCCUAGU AAGCACUAUUUCAUC-AGAAUGUGCUGAUUAUGUCCCUGUCCUUUGUACACACCGCCCGU CGCUACUACCGAUUGAAUGUUU-UAGUGAGAUCUUC-GGCUU-GGUUU----UC-CGAG- CGGCU-CUCG---GGUCGUUCGGUU---UUUAUCGAAAAG----------AUGCUCAAAC UGGAUCAUUUAGAGGAAGUAAAAGUCGUAACAAGGUAUUCGUAGGUGAACCUGCGUAUGG AUCAUUACCGUU---------- >Aedes_albopictus ----------------AUUCUGGUUGAUCCUA-CCAGUAA-UAU-ACGCUUGUCUC-A-A AGGUUAAGCCAUGCAUGUCUAAGUACAAACAG--------------------AU---U-U -----------------------AAU-GU--GA-AAC-C-GCA-UAAGGCUCAGUAUAAC AGCUAUAAU-UUACAAGAUC-AUUUAACUAGUU--------ACUUGG--AUAACUG--U- G-GAAAAUCUAGAGCUAAUACAUGCAAAA--UGCAGG---A---------------A-CC --------------------UCG-C----------------------GG----------A A---CCUGU---GCAAUUAUUAG-UC---AA-AC-C-AAU--------C-GUCC------ ------------------UCC-GU-----------------------G-ACG---CUG-G A-GUU-GAAAUCUGGAUAAUUUUG-CU-GA--UCGUAUG-GU---------------C-U C-G-C--------------ACCGACGACAGAUCUUUCAAAUAUCUG-CCCUAUCA-ACUA UUGAUGGUAGUAUAGAGGACUA-CCAUGGUUGCAACGGGUAACGGGGAAUCAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAAUGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGUA AAUUACCCAAUCCCG--GC----ACGGGGAGGUAGUGACGAGAAAUAACAAUAUAAG-AC UCU-UUUAU--GACGUCU-UAUAAUUGGAAUGAGUUGAGCA--------------UAA-A U-C-----------------CUUCAACAAGGAUCAAGUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCACUAGCGUAUAUUAAAAUUGUUGCGGUUAAAACGUUC GAAGUUUAUUCUUGUCCAA--CACG-G-G-UGC-UACUCCU-----------------UU AUGAUGGC-----------------------A-G-UA-G----GUCACUGGAUUGUUGCG ACUAUA-----------------AGACUGGGU---------------------------- -------------------------------------GCGCCCGUCGGCC--UCGCGGUC GGCGCGGUCGU----AGUG--UGGC-G-CUGAUGCCU-UUCAUC-GGGU--GCAG--U-- -----GUUUC--CGCAAGCCCAGCUGCU-AUUACCUUGAACAAAUUAGAGUGCUCUAAGC AGGC----UAUC-CUACG-----G-C--C-GAGAAU-AAC-U-UGCAUGGAAUAAUGGAA UAUGA----------CC-U--CGGUCUUAAU-AU-UC-AUU-GGUU-UGUAAU-CAG-AU -CAAGAG-GUA------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAC-AGAAGUAGUU G-GGGGCAUUAGUA-UUACGGCGCGAGAGGUGAAAUUCGUAGACCGUCGUAAGACUAACU AAAGCGAAACGAUUUGCCAUGGAUGCUUUCAUUAAUCAAGAACGAAAGUUAGAGGAUCGA AGGCGAUUAGAUACCGCC-CUAGUUCUAACCGUAAACUAUGC-CAAUUAGCAAUUGGGAG ACGCU------------------------------------------------------- -ACAUUAU---------------------------------------------------- -------------------GGUGCUCUCAGUAGCUUCCGGGAAACC-A--AAAU------ ---U--AGGUU-CCGGGGGAAGUAUGG-UUGCAAAGU-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGAAA-ACUU- A-CCA-GGU-CC-GAACUUAU-UGA-GGUAAGA-CAGAUUAAUAGC-UCUU-U-CUCAA- --------------------AAUU-AAGG-GUAGUGGUGCAUGGCCGUUCUUAGUUCGUG GA-AUGAUUUGUCUGGUUAAUUCCGAUAACGAACGUGACUCA-AUCAAAUUAAAUAGAAC GCUAUCA----------------------------------------------------- --------------------------------GCAGUCAGAUGUUUGAUACCGACGGUUC GGGCAACGGUCGC---UCGC-GCGUCGCGCUCGGCCGGCGGUGUAGUGUGACCUGAUAAU ACGUCAACCCAUCG---------------------------------------------- -------------------------------------------------UG-G-----U- --U-G--A-C----UUCUGCUUAAUAGGACA-AUUU-G----UGU-UCAGC-AA-AAUGA -G-AUUGAGCGAUAACAGGUCCGUGAUGCCCUUAGAUGUUCUGGGCUGCACGCGCGCUAC AAUG-UGCGCAGCAACGCGU---------------------------------------- ---------------------AU-CCUUGCCCGAAAGGGCCGGGAAA-UCGC--UUAAAU GCG-CAUUUAGUCGGGAUUAUGGAUUGAAAUGGUCCAU-AUG-AACCUGGAAUUCC-AGU AAGUGCUG-GUCAUU-AGCUAGCGUUGAUUACGUCCCUGCCCUUUGUACACACCGCCCGU CGCUACUACCGAU-GGAUUAUU-UAGUGAGGUCUUU-GAAGG-UGAAC-AU-UU-GCUA- GUCCC-UC-G--GGAU-UA-CAUUU-GAA-U-CGCUGAAGUUGACCGAACUUGACCGAAC UUGAUGAUUUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUA--------------- >Anolis_carolinses ------------------CCUGGUUGAUCCUG-CCAGUAG-CAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAUGUCUAAGUACACACGGG-------------------CG---U-U -----------------------ACA-GU--GA-AAC-U-GCG-AAUGGCUCAUUAAAUC AGUUAUGGU-UCCUUUGGUC-GCUCCCCCCGUU--------CCUUGG--AUAACUG--U- G-GUAAUUCUAGAGCUAAUACAUGCCGACG-AGCGCU---G---------------A-CC ---U-----------------CC-G-----------------G----GG----------A ----UGCGU---GCAUUUAUCAGACC---AAAAC-C-AAC--------C-CGGG------ ------------------CUC-G-----------------------CC-CGGCC-GCU-U U-GGU-GA-CUCUAGAUAACCUCGGGCCGA--UCGCACG-CC---------------C-C C-G-U--------------GGCGGCGACGACGCAUUCGAAUGUCUG-CCCUAUCA-ACUU UCGAUGGUACUUUCUGCGCCUA-CCAUGGUGACCACGGGUAACGGGGAAUCAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCACUCCCG--AC----CCGGGGAGGUAGUGACGAAAAAUAACAAUACAGG-AC UC--UU-UC--GAGGCCC-UGUAAUUGGAAUGAGUCCACUU--------------UAA-A U-C-----------------CUUUAACGAGGAUCCAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUCUUAAAGUUGCUGCAGUUAAAAAGCUC GUAGUUGGAUCUUGGGAUCG-AGCU-G-G-CGG-UCCGCC-------------------- -GCGA----------------------------G-GC-GA---GCUACCGCCUGUCCCAG CCCCUGCC----------------UCUCGGCG---------------------------- ------------------------------------------------------------ ---------------------CUCC-CCCGA-UGCUC-UUAACU-GAGU--GUCC-CG-- -----GG-GG--------UCCGA-AGCG-UUUACUUUGAAAAAAUUAGAGUGUUCAAAGC AGGC-----CG---CUC------G-C--C--GGAAU-ACU-CCAGCUAGGAAUAAUGGAA UAGGA----------CU-C--CGGUUCU--A-UU-UU-GUU-GGUU-----UUCGGA-AC --U-GGG-GCC------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAG-AGGGACGGCC G-GGGGCAUUCGUA-UUGUGCCGCUAGAGGUGAAAUUCUUGGACCGGCGCAAGACGAACC AGAGCGAAAGCAUUUGCCAAGAAUGUUUUCAUUAAUCAAGAACGAAAGUCGGAGGUUCGA AGACGAUCAGAUACCGUC-GUAGUUCCGACCAUAAACGAUGC-CGACUAGCGAUCCGGCG GCGUU------------------------------------------------------- -AUUCCCAU--------------------------------------------------- -------------------GACCCGCCGGGCAGCUUCCGGGAAACC-A--AAGUC----- ---UUUGGGUU-CCGGGGGGAGUAUGG-UUGCAAAGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACCCAACACGGGAAA-CCUC- A-CCC-GGC-CC-GGACACGG-AAA-GGAUUGA-CAGAUCGAUAGC-UCUU-U-CUCGA- --------------------UUCU-GUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GCGAUUUGUCUGGUUAAUUCCGAUAACGAACGAGACUCU-GGCAUGCUAACUAGUUA UGCGACC----------------------------------------------------- ------------------------------------------------------------ ---------------CC-CG--AGC----------------------------------- ------------------------------------------------------------ -----------------------------------------------G-GU-C-----G- --G-C--G-UCC--AACUUCUUAGAGGGACA-AGUG-G----CGU-UCAGC-CA-CCCGA -G-AUUGAGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUCCGGGGCUGCACGCGCGCUAC ACUG-ACUGGCUCAGCGUGU-------------------------------GUC------ ---------------------UACCCUACGCCGACAGGUGCGGGUAACCCGU--UGAACC CCA-UUCGUGAUGGGGAUCGGGGAUUGCAAUUAUUCCCCAUG-AACGAGGAAUUCCCAGU AAGUGCGG-GUCAUA-AGCUCGCGUUGAUUAAGUCCCUGCCCUUUGUACACACCGCCCGU CGCUACUACCGAUUGGAUGGUU-UAGUGAGGUCCUC-GGAUC-GGCCC-CG-CC-GGGG- UCG-G-C-CA---CGG-CCCUGGCG-GAGCG-CCGAGAAG----------ACGGUCGAAC UUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAG- ---------------------- >Arabidopsis_thaliana ----------------UACCUGGUUGAUCCUG-CCAGUAGUCAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAUGUGUAAGUAUGAACGAAU------------------UC---A-G -----------------------ACU-GU--GA-AAC-U-GCG-AAUGGCUCAUUAAAUC AGUUAUAGU-UUGUUUGAUG-GUAACUACU-----------ACUCGG--AUAACCG--U- A-GUAAUUCUAGAGCUAAUACGUGCAACA--AACCCC---G---------------A-CU ---------------------UA-U----------------------GG----------A A---GGGAC---GCAUUUAUUAGAUA--AAAGGU-C-GAC--------G-CGGGC----- ------------------UCU------------------------GCC-CGUUG-CUC-U --GAU-GA-UUCAUGAUAACUCGA-CG-GA--UCGCAUG-GC---------------C-U CUG-U--------------GCUGGCGACGCAUCAUUCAAAUUUCUG-CCCUAUCA-ACUU UCGAUGGUAGGAUAGUGGCCUA-CCAUGGUGGUAACGGGUGACGGAGAAUUAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCAAUCCUG--AC----ACGGGGAGGUAGUGACAAUAAAUAACAAUACUGG-GC UC--UU-UC--GAGU-CU-GGUAAUUGGAAUGAGUACAAUC--------------UAA-A U-C-----------------CCUUAACGAGGAUCCAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUUAAGUUGUUGCAGUUAAAAAGCUC GUAGUUGAACCUUGGGAUGG-GUCG-G-C-CGG-UCCGCC-------------------- -UUU-----------------------------G-GU-G----UGCAUUGGUCGGCUUGU CCCUU-------------------CGGUCGGCG--------------------------- ------------------------------------------------------------ ---------------------AUAC-GCUCC-UGGUC-UUAAUU-GGCC--GGGU--C-- -----GU-GCC------UCCGGC-GC-U-GUUACUUUGAAGAAAUUAGAGUGCUCAAAGC AAGC------C--UAC-------G-C--U-CUGGAU-ACA-UUAGCAUGGGAUAACAUCA UAGGA----------UU-U--CGAUCCU--A-UU-GU-GUU-GGCC-----UUCGGG-AU --C-GGA-GUA------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAC-AGGGACAGUC G-GGGGCAUUCGUA-UUUCAUAGUCAGAGGUGAAAUUCUUGGAUUUAUGAAAGACGAACA ACUGCGAAAGCAUUUGCCAAGGAUGUUUUCAUUAAUCAAGAACGAAAGUUGGGGGCUCGA AGACGAUCAGAUACCGUC-CUAGUCUCAACCAUAAACGAUGC-CGACCAGGGAUCAGCGG AUGUU------------------------------------------------------- -GCUUAUAG--------------------------------------------------- -------------------GACUCCGCUGGCACCUUAUGAGAAAUC-A--AAGUU----- ---UUUGGGUU-CCGGGGGGAGUAUGG-UCGCAAGGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGGAA-ACUU- A-CCA-GGU-CC-AGACAUAG-UAA-GGAUUGA-CAGACUGAGAGC-UCUU-U-CUUGA- --------------------UUCU-AUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GCGAUUUGUCUGGUUAAUUCCGUUAAUGAACGAGACCUC-AGCCUGCUAACUAGCUA CGUGGAGG---------------------------------------------------- ------------------------------------------------------------ ----------------C-AU--C------------------------------------- ------------------------------------------------------------ --------------------------------------------C--C-UU-C------- --A-C--G-GCC--GGCUUCUUAGAGGGACU-AUGG-C----CGU-UUAGG-CC-AAGGA AGUUUGAGGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUUCUGGGCCGCACGCGCGCUAC ACUG-AUGUAUUCAACGAGU-------------------------------UCAC----- ----------------------A-CCUUGGCCGACAGGCCCGGGUAA-UCUU--UGAAAU UUC-AUCGUGAUGGGGAUAGAUCAUUGCAAUUGUUGGUCUUC-AACGAGGAAUUCCUAGU AAGCGCGA-GUCAUC-AGCUCGCGUUGACUACGUCCCUGCCCUUUGUACACACCGCCCGU CGCUCCUACCGAUUGAAUGAUC-CGGUGAAGUGUUC-GGAUC-GCGGC-GA-CG-UGGG- UGG-U-UC-G---CCG-CCCGCGAC-G-U-C-GCGAGAAG----------UCCACUAAAC CUUAUCAUUUAGAGGAAGGAGAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUG--------------- >Caenorhabditis_briggsae ---------------AUACCUGAUUGAUUCUG-UCAGCGC-GAU-AUGCUCAAGUA-A-A AGAUUAAGCCAUGCAUGCUUUGAUUCA--------------------------U---C-A -----------------------A----U--GA-AAU-U-GCG-UACGGCUCAUUAGAGC AGAUAUCACCUUGUUCGGAA-UCCUA---------------AUAUGG--AUAACUG--C- G-GAAAUACUGGAGCUAAUACAUGCAACUA-AACCCC---A---------------A-C- --------------------GUA-A-----------------------G----------G C---GGGGU---GCAAUUAUUAGAAC---AG-AC-C-AAA--------C-GUU------- ------------------UUC-G------------------------G-ACGUU-GUU-U --GUU-GA-CUCUGAAUAAAGCAG-UU-UA--CUGUCAG-U----------------U-U C-G-A---------------CUGACUCUAUCCGAAAAGGGUGUCUG-CCCUUUCA-ACUA --GAUGGUAGUUUAUUGGACUA-CCAUGGUUGUUACGGGUAACGGAGAAUAAGGGUUC-G ACUCCGGAGAGGGAGCCUUAGAAACGGCUACCACGUCCAAGG-AAGGCAGCAGGCGCGAA ACUUAUCCACUGUU---GA----G-UAUGAGAUAGUGACUAAAAAUAUAAAGACUCA-UC C---UU-UU---GGA-UG-AGUUAUUUCAAUGAGUUGAAUA--------------CAA-A U-G-----------------AUUCUUCGAGUAGCAAGGAGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCUCCUAGUGUAUCUCGUUAUUGCUGCGGUUAAAAAGCUC GUAGUUGGAUCUAGGUUACG-UGCU-G---CAG-UUCGCA-------------------- -AUU-----------------------------U-GC-G----UCAACUGUAGUCGUGAC UUCUAAUU----------------UGCUGGUU---------------------------- ------------------------------------------------------------ ------------------------U-G-AGG-UUGGG--UCCG--CCCU--UCAA--C-- ------U-----------GCCAG-CAGG-UUUACCUUGAAUAAAUCAGAGUGCUCAAAAC AAGU------G--UUU-------G-C--U--UGAAU-AGC-UCAUCAUGGAAUAAUGAAA CAGGA----------CU-U--CGGUUCU----UU-UU-GUU-GGUU------CUAGA-AC --U-GAU-UUA------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGGUUAAG-AGGGACAAAC CGGGGGCAUUCGUA-UCAUUACGCGAGAGGUGAAAUUCGUGGACCGUAGUGAGACGCCCA ACAGCGAAAGCAUUUGCCAAGAAUGUCUUCAUUAAUCAAGAACGAAAGUCAGAGGUUCGA AGGCGAUUAGAUACCGCC-CUAGUUCUGACCGUAAACGAUGC-CAUCUCGCGAUUCGGAG GGU--------------------------------------------------------- ---UUUU----------------------------------------------------- -------------------GCCCUGCCGAGGAGCUAUCCGGAAACG-A--AAGUC----- ---UUUCGGUU-CCGGGGGUAGUAUGG-UUGCAAAGC-UGAAACUUAAAGAAAUUGACGG AAGGGCACCACAA-GGCGUGGAGCUUGCGGCUUAAUUUGACUCAACACGGGAAA-ACUC- A-CCC-GGU-CC-GGACACCA-UUA-GGACUGA-CAGAUUGAAAGC-UCUU-U-CUCGA- --------------------UUUG-GUGG-UUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GUGAUUUGUCUGGUUUAUUCCGAUAACGAGCGAGACUCU-AGCCUGCUAAAUAGUUG GCGAAUC----------------------------------------------------- ------------------------------------------------------------ ----------------U-UC--G------------------------------------- ------------------------------------------------------------ --------------------------------------------G--G-UU-C------- --G-U--A-U----AACUUCUUAGAGGGAUA-AGCG-G----UGU-UUAGC-CG-CACGA -G-AUUGAGCGAUAACAGGUCUGUGAUGCCCUUAGAUGUCCGGGGCUGCACGCGUGCUAC ACUG-GUGGACUCAGCGGGU-------------------------------U-------- ---------------------UUUCCUAUGCCGAAAGGUAUCGGUAA-ACCG-UUGAAAU UCU-UCCAUGUCCGGGAUAGGGUAUUGUAAUUAUUGCCCUUA-AACGAGGAAUGCCUAGU AAGUGUGA-GUCAUC-AGCUCACGUUGAUUACGUCCCUGCCCUUUGUACACACCGCCCGU CGCUAUCCGGGACUGAACUGAU-UCGAGAAGAGUGG-GGACU-GUCGC-UU-CG-AGGU- U---U-AA-C-----G-ACUUCGUU-G-U-U-GCGGAAAC----------CAUUUUUAUC GCAUUGGUUUGAACCGGGUAAAAGUCGUAACAAGGUAGCUGUAGGUGAACCUGCAGCUGG AUCAUCG--------------- >Caenorhabditis_elegans ------------------UCUGGUUGAUCCUG-CCAGUAGUCAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAUGCUUUGAUUCA--------------------------U---C-A -----------------------A----U--GA-AAU-U-GCG-UACGGCUCAUUAGAGC AGAUAUCACCUUAUCCGGGA-UCCUC---------------AUAUGG--AUAACUG--C- G-GAAAUACUGGAGCUAAUACAUGCAACUA-UACCCC---A---------------A-C- --------------------GCA-A-----------------------G----------G C---GGGGU---GCAAUUAUUAGAAC---AG-AC-C-AAA--------C-GUU------- ------------------UUC-G------------------------G-ACGUU-GUU-U --GUU-GA-CUCUGAAUAAAGCAG-UU-UA--CUGUCAG-U----------------U-U C-G-A---------------CUGACUCUAUCCGGAAAGGGUGUCUG-CCCUUUCA-ACUA --GAUGGUAGUUUAUUGGACUA-CCAUGGUUGUUACGGGUAACGGAGAAUAAGGGUUC-G ACUCCGGAGAGGGAGCCUUAGAAACGGCUACCACGUCCAAGG-AAGGCAGCAGGCGCGAA ACUUAUCCACUGUU---GA----G-UAUGAGAUAGUGACUAAAAAUAUAAAGACUCA-UC C---UU-UU---GGA-UG-AGUUAUUUCAAUGAGUUGAAUA--------------CAA-A U-G-----------------AUUCUUCGAGUAGCAAGGAGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCUCCUAGUGUAUCUCGUUAUUGCUGCGGUUAAAAAGCUC GUAGUUGGAUCUAGGUUACG-UGCC-U-C-AGA-UUCGCA-------------------- -AUU-----------------------------U-GC-G----UCAACUGGGGGUCGUGA CUUCUAAUU---------------UGCCGGUCU--------------------------- ------------------------------------------------------------ ----------------------------U-G-AGUCC-UUAACA-GGAU--UCUU-AA-- -----CA-GG--------CAUUG-CAAG-UUUACUUUGAACAAACCAGAGUGCUUCAAAC AGGC------GU-UUUC------G-C--U--UGAAU-GGU-CGUGCAUGGAAUAAUAGAA AACGA----------UU-U--CGGUUCA--G-UU-UU-AUU-GGUU-----UUACGG-AC --U-GAG-AUA------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGGUUAAC-AGAGACAAAC G-GGGGCAUUUGUA-UGGCCCCGUGAGAGGUGAAAUUCUUGGACCGUGGCCAGACAAACU ACAGCGAAAGCAUUUGCCAAGAAUGUCUUCAUUAAUCAAGAACGAAAGUCAGAGGUUCGA AGGCGAUUAGAUACCGCC-CUAGUUCUGACCGUAAACGAUGC-CAUCUCGCGAUUCGGAG GGU--------------------------------------------------------- ---UUUU----------------------------------------------------- -------------------GCCCUGCCGAGGAGCUAUCCGGAAACG-A--AAGUC----- ---UUUCGGUU-CCGGGGGUAGUAUGG-UUGCAAAGC-UGAAACUAAAGGAAAUUGACGG AAGGGCACCACAA-GGCGUGGAGCUUGCGGCUUAAUUUGACUCAACACGGGAAA-ACUC- A-CCC-GGU-CC-GGACACCA-UUA-GGACUGA-CAGAUUGAAAGC-UCUU-U-CUCGA- --------------------UUUG-GUGG-UUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GUGAUUUGUCUGGUUUAUUCCGAUAACGAGCGAGACUCU-AGCCUGCUAAAUAGUUG GCGAAUC----------------------------------------------------- ------------------------------------------------------------ ----------------U-UC--G------------------------------------- ------------------------------------------------------------ --------------------------------------------G--G-UU-C------- --G-U--A-U----AACUUCUUAGAGGGAUA-AGCG-G----UGU-UUAGC-CG-CACGA -G-AUUGAGCGAUAACAGGUCUGUGAUGCCCUUAGAUGUCCGGGGCUGCACGCGUGCUAC ACUG-GUGGAGUCAGCGGGU-------------------------------U-------- ---------------------UUUCCUAUGCCGAAAGGUAUCGGUAA-ACCG-UUGAAAU UCU-UCCAUGUCCGGGAUAGGGUAUUGUAAUUAUUGCCCUUA-AACGAGGAAUGCCUAGU AAGUGUGA-GUCAUC-AGCUCACGUUGAUUACGUCCCUGCCCUUUGUACACACCGCCCGU CGCUAUCCGGGACUGAACUGAU-UCGAGAAGAGUGG-GGACU-GUCGC-UU-CG-AGGU- U---U-AA-C-----G-ACUUCGUU-G-U-U-GCGGAAAC----------CAUUUUUAUC GCAUUGGUUUGAACCGGGUAAAAGUCGUAACAAGGUAGCUGUAGGUGAACCUGCAGCAGG AUCA------------------ >Cryptosporidium_hominis ----------------AACCUGGUUGAUCCUG-CCAGUAGUCAUAAUGCUUGUCUC-A-A AGAUUAAGCCAUGCAUGUCUAAGUAUAAACUU--------------------UU---A-U -----------------------ACG-GU--UA-AAC-U-GCG-AAUGGCUCAUUAUAAC AGUUAUAGU-UUACUUGAUA-AUCUUUUACUU---------ACAUGG--AUAACCG--U- G-GUAAUUCUAGAGCUAAUACAUGCGAAA--AAACUC---G---------------A-CU --------------------UUA-U----------------------GG----------A A---GGGUU---GUAUUUAUUAGAUA--AAGAAC-C-AAU-------------------- ------------------AUA-A----------------------------------U-U --GGU-GA-CUCAUAAUAACUUUA-CG-GA--UCACAAU-U----------------A-A U-G-U--------------------GACAUAUCAUUCAAGUUUCUG-ACCUAUCA-GCUU UAGACGGUAGGGUAUUGGCCUA-CCGUGGCAAUGACGGGUAACGGGGAAUUAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCUAAGG-AAGGCAGCAGGCGCGCA AAUUACCCAAUCCUA--AU----ACAGGGAGGUAGUGACAAGAAAUAACAAUACAGG-AC U---UU-UU---GGU-UU-UGUAAUUGGAAUGAGUUAAGUA--------------UAA-A C-C-----------------CCUUUACAAGUAUCAAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGUUGCAGUUAAAAAGCUC GUAGUUGGAUUUCUGUUAAU-AU------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------UUAG--UAU------ -------------------AUGA-AA-U-UUUACUUUGAGAAAAUUAGAGUGCUUAAAGC AGGC------A--UAU-------G-C--C-UUGAAU-ACU-CCAGCAUGGAAUAAUAUUA AAG-A----------UU-U--UUAUCUU----UU-UU-AUU-GGUU------CUAAG-AU --A-AGA-AUA------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAU-AGGGACAGUU G-GGGGCAUUUGUA-UUUAACAGUCAGAGGUGAAAUUCUUAGAUUUGUUAAAGACAAACU AAUGCGAAAGCAUUUGCCAAGGAUGUUUUCAUUAAUCAAGAACGAAAGUUAGGGGAUCGA AGACGAUCAGAUACCGUCCGUAGUCUUAACCAUAAACUAUGC-CAACUAGAGAUUGGAGG UUGUU------------------------------------------------------- ----CCU----------------------------------------------------- -------------------UACUCCUUCAGCACCUUAUGAGAAAUC-A--AAGUC----- ---UUUGGGUU-CUGGGGGGAGUAUGG-UCGCAAGGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGAAA-ACUC- A-CCA-GGU-CC-AGACAUAG-GAA-GGAUUGA-CAGAUUGAUAGC-UCUU-U-CUUGA- --------------------UUCU-AUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GUGAUUUGUCUGGUUAAUUCCGUUAACGAACGAGACCUU-AACCUGCUAAAUAGACA UAAGAAAUA--------------------------------------------------- ------------------------------------------------------------ ----------------U-UA---------------------------------------- ------------------------------------------------------------ -------------------------------------------UA--U-UU-U------- --U-UAUC-U----GUCUUCUUAGAGGGACU-UUGU-A----UGU-UUAAU-AC-AGGGA AGUUUUAGGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUCCUGGGCCGCGCGCGCGCUAC ACUG-AUGCAUCCAUCAAGU-----------------------------AUAUAU----- ----------------------U-CCUGUUUCGAAGGAAAUGGGUAA-UCUU-UUGAAUA UGC-AUCGUGAUGGGGAUAGAUCAUUGCAAUUAUUGAUCUUG-AACGAGGAAUUCCUAGU AAGCGCAA-GUCAUC-AGCUUGCGCUGAUUACGUCCCUGCCCUUUGUACACACCGCCCGU CGCUCCUACCGAUUGAAUGAUC-CGGUGAAUUAUUC-GGACC-AUACU-UU----GUA-- ----G-CA-A--------UAC--AU---G-U-AAGGAAAG----------UUUCGUAAAC CUUAUCAUUUAGAGGAAGGAGAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUC--------------- >Cyanidioschyzon_merolae ----------------UACCUGGUCGAUCCUG-CCAGUAGUCAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAUGUCUAAGUAUAAACCAGU------------------UU---A-U -----------------------ACG-GU--GA-AAC-U-GCG-AAUGGCUCAUUAAAAC AGUUAUCGU-UUAUUUGAUG-GUACCUCCU-----------ACAUGG--AUAACCG--U- A-GGAAUUCUACAGCUAAUACAUGCCCAC--ACACCC---G---------------A-CU ---------------------UU-G----------------------GA----------A ----GGGUG---GGAUUUAUCAGCUA--CAAAAC-C-AAA--------C-CGC------- ------------------CUC-G------------------------G-CGG---UCUCU --GGU-GA-UUCAUGGUAACUGUC-CG-GA--UCGCAUG-UC---------------CUU C-G-G--------------GAUGGCGACAGAUCAUAUAAAUUUCUG-CCCUAUCA-ACUU UCGAUGGUAGGAUAGAGGCCUA-CCAUGGUGGUAACGGGUAACGGGGAAUUAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCAAUCCUG--AC----UCAGGGAGGUAGUGACAAGAAAUAACGAGACCGG-GC UC--UU--C--GAGU-CC-GGUAAUCGGAAUGAGUACAACU--------------UAA-A U-A-----------------ACUUAACGAGGAUCCAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGUUGCAGUUAAAACGCUC GUAGUCGCAGCUCGGACGCG-GCCC-A-C-GGG-CCGGCC-------------------- -GCAG----------------------------G-CU-U----GCGCCGGUGGGCCGGGU CUUU--------------------CGGCUGG----------------------------- ------------------------------------------------------------ ----------------UGAG--CGC-G-CGG-GGUCC--UCGCG-GGCUC-CGCG--C-- -----GG----CGAG---CCAGC-CC-G-UUUACUGUGAACAAAUUAGAGUGCUCCAGGC AGGC------G--UUC-------G-C--A--UGCAU-ACG-UUAGCAUGGAAUAAUAGAA UAUAGG--------ACU-U--GGGUCCU--G-UU-UU-GUU-GGUU-----UUGAGG-GC --C-GAA-GUA------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUGAAU-AGGGACAGUC G-GGGGCAUUCGUA-UUCCAUUGUCAGAGGUGAAAUUCUUGGAUUUAUGGAAGACGAACA ACAGCGAAAGCAUCUGCCAAGGAUGUUUUCAUUGAUCAAGAACGAAAGUUAGGGGAUCGA AGACGAUUAGAUACCGUC-GUAGUCUUAACCAUAAACGAUGC-CGACUCGGGAUCGGUGG AGCAC------------------------------------------------------- ---AAGA----------------------------------------------------- -------------------UACUCCAUCGGCACCGUAGGAGAAAUC-A--AAGUG----- ---UUUGGGUU-CUGGGGGGAGUAUGG-UCGCAAGGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGAAA-ACUU- A-CCA-GGU-CC-GGACAUAG-GGA-GGAUUGA-CAGAUUGAGAGC-UCUU-U-CUUGA- --------------------UUCU-AUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GUGAUUUGUCUGGUUAAUUCCGUUAACGAACGAGACCUU-AACCUGCUAACUAGCGG CGCGAAA----------------------------------------------------- ------------------------------------------------------------ ----------------C-GC--G------------------------------------- ------------------------------------------------------------ --------------------------------------------G--U-UU-C------- --G-CG---GU---CGCUUCUUAGAGGGACG-AUCU-G----CGU-CUAGC-AG-AGGGA AGUUUGAGGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUCCUGGGCUGCACGCGCGCUAC ACUG-AUGCAGGCAACGAGC-------------------------------GC------- ----------------------C-GCUGCGCCGAGAGGCGUGGCGAA-UCUG-CC-AAUC UGC-AUCGUGCUGGGGAUAGACCCUUGGAAUUAUGGGUCUUC-AACGAGGAAUUCCUUGU AAGCGCGA-GUCAUC-AGCUCGCGCUGAAUACGUCCCUGCCCUUUGUACACACCGCCCGU CGCUCCUACCGAUUGAAUGAUC-CGGUGAGUUGUCC-GGACG-GGCGC-GCCAC-CGGC- CGG-U-UC-G---CCG-GCGCGGGC-G-C-G-CCCGAAAG----------CUCAACAAAC CUUAUCAUUUAGAGGAAGGAGAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUCUCAAACGGAACAC-- >Danio_rerio ----------------UACCUGGUUGAUCCUG-CCAGUAA-CAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAGGUCUAAGUGCACACGGC-------------------CG---G-U -----------------------ACA-GU--GA-AAC-U-GCG-AAUGGCUCAUUAAAUC AGUUAUGGU-UCCUUUGAUC-GCUCCAUCCGUU--------ACUUGG--AUAACUG--U- G-GCAAUUCCAGAGCUAAUACAUGCCAACG-AGCGCC---G---------------A-CC ---CG---------G-UCCCCCC-GGGGG-----------CCGG---GG----------A ----CGCGU---GCAUUUAUCAGAUCC--AAAAC-CCA-U--------C-CGGGUGCGGC GUGGGCUCCCC--C----CUC-G---GGGGUCGGGCCU----CGUCCCCCGGCC-GCU-U U-GGU-GA-CUCUAGAUAACCUCGGGCCGA--UCGCGCG-CC---------------C-U CCG-C--------------GGCGGCGACGAUUCAUUCGAAUGUCUG-CCCUAUCA-ACUU UCGAUGGUACUUUAGGCGCCUA-CCAUGGUGACCACGGGUAACGGGGAAUCAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCAUUCCCG--AC----ACGGGGAGGUAGUGACGAAAAAUAACAAUACAGG-UC UC--UU-UC--GAGGCCC-UGUAAUUGGAAUGAGCGUAUCC--------------UAA-A C-C-----------------CAUGGGCGAGGACCCAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGCUGCAGUUAAAAAGCUC GUAGUUGGAUCUCGGGAGUG-GGCU-G-G-CGG-UCCGCC-------------------- -GCGA----------------------------G-GC-GA---GCCACCGCCUGUCCCGG ACCCUGCC----------------UCCCGGCG---------------------------- ------------------------------------------------------------ ---------------------CCCC-CCGGA-UGCCC-UUAGCU-GGGU--GUCC--GGU ACCUCGG-GG--------CCCGG-AGCG-UUUACUUUGAAAAAAUUAGAGUGUUCAAAGC AGGC----CGCCCAGCC------G-CCGC--UGAAU-ACC-GCAGCUAGGAAUAAUGGAA UAGGA----------CU-C--CGGUUCU--A-UU-UU-GUG-GGUU-----UCUGGA-AC --C-CGGGGCC------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUGAG-AGGGACGGCC G-GGGGCAUUCGUA-UUGCGCCGCUAGAGGUGAAAUUCUUGGACCGGCGCAAGACGGACG AAAGCGAAAGCAUUUGCCAAGAAUGUUUUCAUUAAUCAAGAACGAAAGUCGGAGGUUCGA AGACGAUCAGAUACCGUC-GUAGUUCCGACCGUAAACGAUGC-CGACCCGCGAUCCGGCG GCGUU------------------------------------------------------- -AUUCCCAU--------------------------------------------------- -------------------GACCCGCCGGGCAGCGUGCGGGAAACC-AC-GAGUC----- ---UUUGGGUU-CCGGGGGGAGUAUGG-UUGCAAAGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGAAA-CCUC- A-CCC-GGC-CC-GGACACGG-AAA-GGAUUGA-CAGAUUGAUAGC-UCUU-U-CUCGA- --------------------UUCU-GUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GCGAUUUGUCUGGUUCAUUCCGAUAACGAACGAGACUCC-GGCAUGCUAAAUAGUUA CGCGGCC----------------------------------------------------- ------------------------------------------------------------ ----------------C-CG--CGC----------------------------------- ------------------------------------------------------------ -----------------------------------------------G-GU-C-----G- --G-C--G-UC-CCAACUUCUUAGAGGGACA-AGUG-G----CGU-UCAGC-CA-CGCGA -G-AUGGAGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUCCGGGGCUGCACGCGCGCCAC AAUG-GGCGGAUCAACGUGU-------------------------------GCC------ ---------------------UACCCUGCGCCGAGAGGCGCGGGUAACCCGU--UGAACC CCG-CUCGUGAUUGGGACUGGGGCUUGAAACUGUUUCCCAUC-AACGAGGAAUUCCCAGU AAGCGCAG-GUCAUA-AGCUUGCGUUGAUUAAGUCCCUGCCCUUUGUACACACCGCCCGU CGCUACUACCGAUUGGAUGGUU-UAGUGAGGUCCUC-GGAUC-GGCCC-CG-CC-GGGGC UCC---UC-GC--CGGGCCCUGGCG-GAGCG-CCGAGAAG----------ACGAUCAAAC UUGAUCCUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUA--------------- >Dictyostelium_discoideum -----------AUGCUUAACUGGUUGAUCCUG-CCAGUAGUCAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAUGUCUAAGUAUAAAUU---------------------CU---U-G U----------------------ACG-AU--GA-AAC-U-GCA-GACGGCUCAUUACAAC AGUGAUAAA-CUAAUAGACU-UUCGGGUUUUACCU------U-UUGG--AUAACCG--C- A-GUAAAUC-GGGGCUAAUACAUACAAGCG-AUGGGU-GA-----------------CUG --------------------GCA-A----------------------CGG---------- -AA-GCUCA---GCGAUUAUUAGCAU------UC-U-ACC--------A-AU-------- ------------------GCC-U------------UCG----GG-------U----UU-U G-GGU-GA-UACCGAAUAAUAUUG-CA-GA--UCGAGGA-UU---------------U-A UCU-U-------------------CGACAAGUCUACUGUGUCACUG-CCCUAUCA-ACUU UCGAUGGUACGGUAUUGGCCUA-CCAUGGUUGUAACGGGUAACGGGGAAUUAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAAUGGCUACCACUUCUACGG-AAGGCAGCAGGCGCGCA AAUUACUCAAUCCCA--AU----ACGGGGAAGUAGUGACAAUAAAUAUCAAUACCUA-UC CU--UU-UU----GG-AG-GGCAAUUGAAAUGAACACAAAU--------------UAA-A A-C-----------------UCUUAAUUAACA-CAAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCAUAUACUAAAGUUGUUGCAGUUAAAAAGCUC GUAGUUGAAGUUUAAGGUUU-ACCG-G-G--UU-UAUGUCAUUUACCA------------ CUUCGU-----------------G-GUUAA-AU-CGA-C-----ACCGGUAUCUCUUUCU UA----------------------AUAGUUCAG--------------------------- ------------------------------------------------------------ ---------------------CUUG-U--AU-UAUCU-UUGA-UA-------GUG--C-- -----UU-G--------UUUGGA-CA-U-UUCACUGUGAGAAAAUUGUGGUGUUUAAAGC AGGC------G--UCU-------C-G--C--UGAUCUUUU-GCAGCAUGGUAUGAUGAAA CAUGA----------CA-U--U----UU--A-CG-CU-AUU-GGUUU------GCGUUUA --A-AGU-GUA------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAU-AGGGAUGGAU G-GGGGUGUUCAUA-UUGGUGGGCGAGAGGUGAAAUUCGUUGACCCUAUCAAGAUGAACU UCUGCGAAAGCAUUCACCAAAUACUUCCCCAUUAAUCAAGAACGAAAGUUUGGGGAUCGA AGACGAUCAGAUACCGUC-GUAGUCCAAACUAUAAACUAUGU-CGACCAGGGAUCGGUUA AAAUUU------------------------------------------------------ ---UUUCA---------------------------------------------------- ------------------AAAUUUAAUCGGCACCUUGUGAGAAAUC-AU-GAGUG----- ---UUUAGAUU-CCGGGGGGAGUAUGG-UCGCAAGUC-UGAAACUUAAAGGAAUUGACGG AAGGGCA-CACAAUGGAGUGGAGCCUGCGGCUUAAUUUGACUCAACUCGGGAAA-ACUU- A-CCA-AGC-UA-AGAUAUAG-UAA-GGAUUGA-CAGACUAAAAGA-UCUU-U-CAUGA- --------------------UUCU-AUAA-GUGGUGGUGCAUGGUCGUUCUUAGUUGGUG GA-GCGAUUUGUCUGGUCAAUUCCGAUAACGGACGAGACCUC-GACCUGCUAACUAGUAG UAUUUAUUA--------GUCGAUAUAGACG-AUA----GCUU-----U-UC-UG------ -GGGU-UUG--------------------------------------------------- ----------------G-AA--U------------------------------------- -------------------------------------GAU---UUC---------GGUCA U-CUCCUGCUUCAAGGAGUGUGU-A--GUCUGACU---CGAUAG---G-UACG------- --A-A----U-UAAAACUUCUUAGAGGGACU-ACCU-G----CCU-CAAGC-AG-GCGGA AGUCCGAGGCAAUAACAGGUCUGUGAUGCCCUUAGAUACCUUGGGCCGCACGCGCGCUAC AAUG-UAGGAAACAAAAAGG-------------------------------C-------- ----------------------U-CCUGGUCCGGAAGGAUUGGGUAA-UCAU-UUGAAUU UCC-UACGUAACUGGGCUUGAUCUUUGUAAUUAUUGAUCAUA-AACGAGGAAUUCCUUGU AAGCGUAA-GUCAUU-ACCUUAUGCUGAAUAUGUCCCUGCCCUUUGUACACACCGCCCGU CGCUCCUACCGAUCGAAUGAUA-CGGUAAAGUUAAC-GGAUC-GUUUUAUC-UGUG---- ----G-CA-ACA--------CUGAU-A-U-AAAUUAAAAG----------UUAUUUAAAU CUCAUUGUUUAGAGGAAGGAGAAGUCGUAACAAGGUAUCCGUAGGUGAACCUGCGGAUGG AUCAUUU--------------- >Drosophila_melanogaster ----------------AUUCUGGUUGAUCCUG-CCAGUAGUUAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAUGUCUAAGUACACACGA--------------------AU---U-A -----------------------AAA-GU--GA-AAC-C-GCA-AAAGGCUCAUUAUAUC AGUUAUGGU-UCCUUAGAUC-GUUAACAGUU----------ACUUGG--AUAACUG--U- G-GUAAUUCUAGAGCUAAUACAUGCAAUUAAAACAUG---A---------------A-CC --------------------UUA-U-----------------G----GG----------A ----CGUGU---GCUUUUAUUAGGCU---AAAAC-C-AA---------G-CGAUC----- ------------------GCA-A----------------------GAU-CGUUA-UAU-U --GGUUGAACUCUAGAUAACAUG--CA-GA--UCGUAUG-GU---------------C-U U-G-U--------------ACCGACGACAGAUCUUUCAAAUGUCUG-CCCUAUCA-ACUU UUGAUGGUAGUAUCUAGGACUA-CCAUGGUUGCAACGGGUAACGGGGAAUCAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCUAAGG-AAGGCAGCAGGCGCGUA AAUUACCCACUCCCA--GC----UCGGGGAGGUAGUGACGAAAAAUAACAAUACAGG-AC UCA-UAUCC--GAGGCCC-UGUAAUUGGAAUGAGUACACUU--------------UAA-A U-C-----------------CUUUAACAAGGACCAAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGUUGCGGUUAAAACGUUC GUAGUUGAACUUGUGCUUCA-UACG-G-G-UAG-UACAACUUACA--------------- -AUU-------------------------G-U-G-GU-U-AGUACUAUACCUUUAUGUAU GUAAGCGUAU--------------UACCGGUG------GAGUUCUUAUAUGUGAUUAAAU ACUUGUAUUUUUUCAUAUGUUCCUCCUAUUUAAAAAC----------------------- ---------------------CUGC-AUUAG-UGCUC-UUAAAC-GAGU--GUUA-UU-- -----GU-GG--------GCCGG-UACU-AUUACUUUGAACAAAUUAGAGUGCUUAAAGC AGGC-----UUC-AAAU------G-C--C--UGAAUAUUC-UGUGCAUGGGAUAAUGAAA UAAGA----------CC-U--CUGUUCU--GCUU-UC-AUU-GGUU-----UUCAGA-UC -AA-GAG-GUA------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAU-AGAAGCAGUU UGGGGGCAUUAGUA-UUACGACGCGAGAGGUGAAAUUCUUGGACCGUCGUAAGACUAACU UAAGCGAAAGCAUUUGCCAAAGAUGUUUUCAUUAAUCAAGAACGAAAGUUAGAGGUUCGA AGGCGAUCAGAUACCGCC-CUAGUUCUAACCAUAAACGAUGC-CAGCUAGCAAUUGGGUG UAGCU------------------------------------------------------- -ACUUUUAU--------------------------------------------------- -------------------GGCUCUCUCAGUCGCUUCCGGGAAACC-A--AAGCU----- --UUUUGGGCU-CCGGGGGAAGUAUGG-UUGCAAAGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGAAA-ACUU- A-CCA-GGU--C-GAACAUAA-GUG-UGUAAGA-CAGAUUGAUAGC-UCUU-U-CUCGA- --------------------AUCU-AUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUCGUG GA-GUGAUUUGUCUGGUUAAUUCCGAUAACGAACGAGACUCA-AAUAUAUUAAAUAGAUA UCUUCAGGA--------U--U--------AU-GGUGCUGAAGCU---------------- --------------------------------------------UAUGUAGCCUUCAUUC AUGUUGGCAGUAAAAUGCUU-AUUGUGUUUGAAUGUGUUUAUGUAAGUGGAGCCGUACC- ------------------------------------------------------------ -------------UG--------UUGGU-UUGUCCCAU-U--AU---AAGG-A------- --C-A--C-U----AGCUUCUUAAAUGGACA-AAUU-G----CGU-CUAGC-AA-UAAUG AG-AUUGAGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUCCUGGGCUGCACGCGCGCUAC AAUG-AAAGUAUCAACGUGU------------------------------AUU------- ----------------------U-CCUAGACCGAGAGGUCCGGGUAAACCGC--UGAACC ACU-UUCAUGCUUGGGAUUGUGAACUGAAACUGUUCACGAUG-AACUUGGAAUUCCCAGU AAGUGUGA-GUCAUU-AACUCGCAUUGAUUACGUCCCUGCCCUUUGUACACACCGCCCGU CGCUACUACCGAUUGAAUUAUU-UAGUGAGGUCUCC-GGACG-UGAUC-AC-UG-UGAC- GC--C-UU-GC---GU-GUUACGGUUGUU-U-CGCAAAAG----------UUGACCGAAC UUGAUUAUUUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUA--------------- >Eremothecium_gossypii ----------------UAUCUGGUUGAUCCUG-CCAGUAGUCAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAUGUCUAAGUAUAAGCAAU-------------------UU---A-U -----------------------ACA-GU--GA-AAC-U-GCG-AAUGGCUCAUUAAAUC AGUUAUCGU-UUAUUUGAUA-GUUCCUUUACU---------ACAUGG--AUAUCUG--U- G-GUAAUUCUAGAGCUAAUACAUGCUUAA--AAUCUC---G---------------A-CC --------------------UUU-U----------------------GG----------A A---GAGAU---GUAUUUAUUAGAUA--AAAAAU-C-AAU--------G-UC-------- ------------------UUC-G--------------------------GACUC--UU-U --GAU-GA-UUCAUAAUAACUUUU-CG-AA--UCGCAUG-GC---------------C-U U-G-U--------------GCUGGCGAUGGUUCAUUCAAAUUUCUG-CCCUAUCA-ACUU UCGAUGGUAGGAUAGUGGCCUA-CCAUGGUUUCAACGGGUAACGGGGAAUAAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCAAUCCUA--AU----UCAGGGAGGUAGUGACAAUAAAUAACGAUACAGG-GC CC--AU-AC--GGGU-CU-UGUAAUUGGAAUGAGUACAAUG--------------UAA-A U-A-----------------CCUUAACGAGGAACAAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGUUGCAGUUAAAAAGCUC GUAGUUGAACUUUGGGUUUG-GUUG-G-C-CCG-UCCGAU-------------------- -UUUC----------------------------U-UC-G----UGUACGGGAUCCAACCG AACCUUUC----------------CUUCUGGCU--------------------------- ------------------------------------------------------------ ---------------------AACC-U---A-GGGUA--CUUGU--ACU--CU----A-- -----GG-CGA------ACCAGG-AC-U-UUUACUUUGAAAAAAUUAGAGUGUUCAAAGC AGGC------G--CAA-------G-C--U--CGAAU-AUA-UUAGCAUGGAAUAAUGGAA UAGGA----------CGUU--UGGUUCU--A-UU-UU-GUU-GGUU-----UCUAGG-AC --C-AUC-GUA------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAU-AGGGACGGUC G-GGGGCAUCAGUA-UUCAAUUGUCAGAGGUGAAAUUCUUGGAUUUAUUGAAGACUAACU ACUGCGAAAGCAUUUGCCAAGGACGUUUUCAUUAAUCAAGAACGAAAGUUAGGGGAUCGA AGAUGAUCAGAUACCGUC-GUAGUCUUAACCAUAAACUAUGC-CGACUAGGGAUCGGGUG GUGUU------------------------------------------------------- --UUCUUAU--------------------------------------------------- -------------------GACCCACUCGGCACCUUACGAGAAAUC-A--AAGUC----- ---UUUGGGUU-CUGGGGGGAGUAUGG-UCGCAAGGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGGAA-ACUC- A-CCA-GGU-CC-AGACACAA-UAA-GGAUUGA-CAGAUUGAGAGC-UCUU-U-CUUGA- --------------------UUUU-GUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GUGAUUUGUCUGCUUAAUUGCGAUAACGAACGAGACCUU-AACCUACUAAAUAGUGC UGCUAGC----------------------------------------------------- ------------------------------------------------------------ ----------------A-UU--U------------------------------------- ------------------------------------------------------------ -----------------------------------------------G-CU-G------- --G-U--U-GCG--CACUUCUUAGAGGGACU-AUCG-G----UUU-CAAGC-CG-AUGGA AGUUUGAGGCAAUAACAGGUCUGUGAUGCCCUUAGACGUUCUGGGCCGCACGCGCGCUAC ACUG-ACGGAGCCAGCGAGU-------------------------------AUA------ ----------------------A-CCUUGGCCGAGAGGUCUGGGUAA-UCUU-GUGAAAC UCC-GUCGUGCUGGGGAUAGAGCAUUGCAAUUAUUGCUCUUC-AACGAGGAAUUCCUAGU AAGCGCAA-GUCAUC-AGCUUGCGUUGAUUACGUCCCUGCCCUUUGUACACACCGCCCGU CGCUAGUACCGAUUGAAUGGCU-UAGUGAGGCCUCA-GGAUC-UGCUU-AG-AG-GAGG- GG--G-CA-A----CU-CCACCUCA-G-A-G-CGGAAAAU----------CUGGUCAAAC UUGGUCAUUUAGAGGAACUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUA--------------- >Gallus_gallus ----------------UACCUGGUUGAUCCUG-CCAGUAG-CAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAUGUCUAAGUACACACGGG-------------------CG---G-U -----------------------ACA-GU--GA-AAC-U-GCG-AAUGGCUCAUUAAAUC AGUUAUGGU-UCCUUUGGUC-GCUCCCCUCCCGUU------ACUUGG--AUAACUG--U- G-GUAAUUCUAGAGCUAAUACAUGCCGACG-AGCGCC---G---------------A-CC ---U-----------------CC-G-----------------G----GG----------A ----CGCGU---GCAUUUAUCAGACC---AAAAC-C-AAC--------C-CGGG------ ------------------CUC-G-----------------------CC-CGGCG-GCU-U U-GGU-GA-CUCUAGAUAACCUCGAGCCGA--UCGCACG-CC---------------C-C C-G-U--------------GGCGGCGACGACCCAUUCGAAUGUCUG-CCCUAUCA-ACUU UCGAUGGUACUGUCUGUGCCUA-CCAUGGUGACCACGGGUAACGGGGAAUCAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCACUCCCG--AC----CCGGGGAGGUAGUGACGAAAAAUAACAAUACAGG-AC UC--UU-UC--GAGGCCC-UGUAAUUGGAAUGAGUCCACUU--------------UAA-A U-C-----------------CUUUAACGAGGAUCCAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGCUGCAGUUAAAAAGCUC GUAGUUGGAUCUUGGGAUCG-AGCU-G-G-CGG-UCCGCC-------------------- -GCGA----------------------------G-GC-GA---GCUACCGCCUGUCCCAG CCCCUGUC----------------UCUCGGCG---------------------------- ------------------------------------------------------------ ---------------------CCCC-CUCGA-UGCUC-UUAACU-GAGU--GUCC-CGC- -----GG-GG--------CCCGA-AGCG-UUUACUUUGAAAAAAUUAGAGUGUUCAAAGC AGGC-----UG---GCC------G-C--C--GGAAU-ACU-CCAGCUAGGAAUAAUGGAA UAGGA----------CU-C--CGGUUCU--A-UU-UU-GUU-GGUU-----UUCGGA-AA --C-GGG-GCC------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAG-AGGGACGGCC G-GGGGCAUUCGUA-UUGUGCCGCUAGAGGUGAAAUUCUUGGACCGGCGCAAGACGAACU AAAGCGAAAGCAUUUGCCAAGAAUGUUUUCAUUAAUCAAGAACGAAAGUCGGAGGUUCGA AGACGAUCAGAUACCGUC-GUAGUUCCGACCAUAAACGAUGC-CGACUCGCGAUCCGGCG GCGUU------------------------------------------------------- -AUUCCCAU--------------------------------------------------- -------------------GACCCGCCGGGCAGCUCCCGGGAAACC-C--AAGUC----- ---UUUGGGUU-CCGGGGGGAGUAUGG-UUGCAAAGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGAAA-CCUC- A-CCC-GGC-CC-GGACACGG-ACA-GGAUUGA-CAGAUUGAGAGC-UCUU-U-CUCGA- --------------------UUCC-GUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GCGAUUUGUCUGGUUAAUUCCGAUAACGAACGAGACUCU-GGCAUGCUAACUAGUUA CGCGACC----------------------------------------------------- ------------------------------------------------------------ ---------------CC-CG--AGC----------------------------------- ------------------------------------------------------------ -----------------------------------------------G-GU-C-----G- --G-C--G-UCC--AACUUCUUAGAGGGACA-AGUG-G----CGU-UCAGC-CA-CCCGA -G-AUUGAGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUCCGGGGCUGCACGCGCGCUAC ACUG-ACUGGCUCAGCUUGU-------------------------------GUC------ ---------------------UACCCUACGCCGGCAGGCGCGGGUAACCCGU--UGAACC CCA-UUCGUGAUGGGGAUCGGGGAUUGCAAUUAUUCCCCAUG-AACGAGGAAUUCCCAGU AAGUGCGG-GUCAUA-AGCUCGCGUUGAUUAAGUCCCUGCCCUUUGUACACACCGCCCGU CGCUACUACCGAUUGGAUGGUU-UAGUGAGGUCCUC-GGAUC-GGCCC-CG-GC-GGGG- UCG-G-C-CA---CGG-CCCUGCCG-GAGCG-UCGAGAAG----------ACGGUCGAAC UUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUA--------------- >Guillardia_theta ----------------UACCUGGUUGAUCCUG-CCAGUAGUCAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAUGUCUUAGUGUAAAAUAA-------------------CU---C-U -----------------------A-U--U--GA-AAC-U-GCG-AAUGGCUCAUUAAAUC AGUUAUCGU-UUAUUUGAUG-GUUCCUUACU----------ACAUGG--AUAACCG--U- A-GUAAUUCUAGAGCUAAUACAUGCACCA--AGGCCC---G---------------A-CU ---------------------CA-C----------------------GG----------A ----GGGUU---GUAUUUAUUAGAUU--CAAAAC-C-AGC-------------------- ------------------ACC-A---------------------------------CC-U --GGU-GA-UUCAUAGUAACUAAA-CG-AA--CCGCAUG-CC---------------U-U U-A-U--------------GGUGGCGGUGAUUCAUUCAAAUUUCUG-CCCUAUCA-ACUU UCGAUGGUAGGAUAGAGGCCUA-CCAUGGUUUUAACGGGUGACGGAGAAUUAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAGACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCAAUCCCG--AC----UCGGGGAGGUAGUGACAAUAAAUAACAAUACAGG-GC C---AA--C---GGU-CU-UGUUAUUGGAAUGAGAACAAUU--------------UAA-A U-C-----------------CCUUAACGAGGAUCAAUUAGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCUAAUAGCGUAUAUUAAAGUUGUUGCAGUUAAAAAGCUC GUAGUCGGAAGUCGGGCUCG-GGCA-G-G-CUG-UCGGC--------------------- CUCG-------------------------------GU-U----GGGCAGCUUGCUUGGGU CUUCU-------------------AGCUCGGGG--------------------------- ------------------------------------------------------------ ----------------------GCC-C-CGU-GCCAU-UUAACC-GUGG--UGCG-CG-- -----GG-AA-------CACGGG-CC-G-UUUACUUUGAAAAAAUUAGAGUGUUCAAAGC AGGC------C--UAC-------G-C--U--UGAAU-ACA-UUAGCAUGGAAUAAUGGAA UAGGA----------CU-U--UGGUGCU--A-UU-UC-GUU-GGUU-----AAUGGG-AC --C-GAA-GUA------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAA-AGGGACAGUU G-GGGCCGUUUAUA-UUUCGUUGUCAGAGGUGAAAUUCUUGGAUUUACGAAAGAUAAACU UCUGCGAAAGCAUUCGGCAAGGAUGUUUUCAUUGAUCAAGAACGAAAGUUAGGGGAUCGA AGACGAUCAGAUACCGUC-GUAGUCUUAACCAUAAACUAUGC-CGACUAGGGAUCAGUGG AUGUC------------------------------------------------------- --AAUUUGC--------------------------------------------------- -------------------GACGCCAUUGGCACCUUGUGAGAAAUC-A--AAGUU----- ---UUUGGGUU-CCGGGGGGAGUAUGG-UCGCAAGGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGGAA-ACUU- A-CCA-GGU-CC-AGACAUAG-UAA-GGAUUGA-CAGAUUGAAAGC-UCUU-U-CUUGA- --------------------UUCU-AUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GUGAUUUGUCUGGUUAAUUCCGUUAACGAACGAGACCUC-AGCCUGCUAACUAGCAU CGCGAAUA---------------------------------------------------- ------------------------------------------------------------ ----------------U-U----------------------------------------- ------------------------------------------------------------ --------------------------------------------G--A-UU-G------- --G-C--G-AG---GGCUUCUUAGAGGGACU-AUUU-G----UGU-UUAAU-GA-AUGGA AGUUUGAGGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUUCUGGGCCGCACGCGCGCUAC ACUG-AUGAACGCAACGAGC-------------------------------UCGA----- ----------------------C-CCUGAACCGAAAGGCCUGGGUAA-ACUU-GUGAAAG UUC-AUCGUGAUGGGGAUAGAUUAUUGCAAUUAUUAAUCUUC-AACGAGGAAUUCCUAGU AAGCGCGA-GUCAUC-AGCUCGCGUUGAUUACGUCCCUGCCCUUUGUACACACCGCCCGU CGCUCCUACCGAUUGAAUGGUC-CGGUGAAAUCUUC-GGAUU-GCUGG-CC-AU-UUGC- C---G-CA-A-----G-GUGAGU-G-G-U-U-GCGAGAAG----------UUGAUUGAAC CUUAUCAUUUAGAGGAAGGAGAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUGA--------------- >Homo_sapiens ----------------UACCUGGUUGAUCCUG-CCAGUAG-CAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAUGUCUAAGUACGCACGGC-------------------CG---G-U -----------------------ACA-GU--GA-AAC-U-GCG-AAUGGCUCAUUAAAUC AGUUAUGGU-UCCUUUGGUC-GCUCGCUCCUCUCCU-----ACUUGG--AUAACUG--U- G-GUAAUUCUAGAGCUAAUACAUGCCGACG-GGCGCU---G---------------A-CC ---CC---------C-UU----C-GCGG------------GGG----GG----------A ----UGCGU---GCAUUUAUCAGAUC---AAAAC-C-AAC--------C-CGGUC-AGCC CC-U-CUCCGG--C----CCC-G---GCCGGGGGGCGG----GC--GC-CGGCG-GCU-U U-GGU-GA-CUCUAGAUAACCUCGGGCCGA--UCGCACG-CC---------------C-C CCG-U--------------GGCGGCGACGACCCAUUCGAACGUCUG-CCCUAUCA-ACUU UCGAUGGUAGUCGCCGUGCCUA-CCAUGGUGACCACGGGUGACGGGGAAUCAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCACUCCCG--AC----CCGGGGAGGUAGUGACGAAAAAUAACAAUACAGG-AC UC--UU-UC--GAGGCCC-UGUAAUUGGAAUGAGUCCACUU--------------UAA-A U-C-----------------CUUUAACGAGGAUCCAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGCUGCAGUUAAAAAGCUC GUAGUUGGAUCUUGGGAGCG-GGCG-G-G-CGG-UCCGCC-------------------- -GCGA----------------------------G-GC-GA---GCCACCGCCCGUCCCCG CCCCUUGCC---------------UCUCGGCG---------------------------- ------------------------------------------------------------ ---------------------CCCC-CUCGA-UGCUC-UUAGCU-GAGU--GUCC-CGC- -----GG-GG--------CCCGA-AGCG-UUUACUUUGAAAAAAUUAGAGUGUUCAAAGC AGGC----CCG--AGCC------G-C--C--UGGAU-ACC-GCAGCUAGGAAUAAUGGAA UAGGA----------CC-G--CGGUUCU--A-UU-UU-GUU-GGUU-----UUCGGA-AC --U-GAG-GCC------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAG-AGGGACGGCC G-GGGGCAUUCGUA-UUGCGCCGCUAGAGGUGAAAUUCUUGGACCGGCGCAAGACGGACC AGAGCGAAAGCAUUUGCCAAGAAUGUUUUCAUUAAUCAAGAACGAAAGUCGGAGGUUCGA AGACGAUCAGAUACCGUC-GUAGUUCCGACCAUAAACGAUGC-CGACCGGCGAUGCGGCG GCGUU------------------------------------------------------- -AUUCCCAU--------------------------------------------------- -------------------GACCCGCCGGGCAGCUUCCGGGAAACC-A--AAGUC----- ---UUUGGGUU-CCGGGGGGAGUAUGG-UUGCAAAGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGAAA-CCUC- A-CCC-GGC-CC-GGACACGG-ACA-GGAUUGA-CAGAUUGAUAGC-UCUU-U-CUCGA- --------------------UUCC-GUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GCGAUUUGUCUGGUUAAUUCCGAUAACGAACGAGACUCU-GGCAUGCUAACUAGUUA CGCGACC----------------------------------------------------- ------------------------------------------------------------ ---------------CC-CG--AGC----------------------------------- ------------------------------------------------------------ -----------------------------------------------G-GU-C-----G- --G-C--GUCCCCCAACUUCUUAGAGGGACA-AGUG-G----CGU-UCAGC-CA-CCCGA -G-AUUGAGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUCCGGGGCUGCACGCGCGCUAC ACUG-ACUGGCUCAGCGUGU-------------------------------GCC------ ---------------------UACCCUACGCCGGCAGGCGCGGGUAACCCGU--UGAACC CCA-UUCGUGAUGGGGAUCGGGGAUUGCAAUUAUUCCCCAUG-AACGAGGAAUUCCCAGU AAGUGCGG-GUCAUA-AGCUUGCGUUGAUUAAGUCCCUGCCCUUUGUACACACCGCCCGU CGCUACUACCGAUUGGAUGGUU-UAGUGAGGCCCUC-GGAUC-GGCCC-CG-CC-GGGG- UCG-G-CCCA---CGG-CCCUGGCG-GAGCG-CUGAGAAG----------ACGGUCGAAC UUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUA--------------- >Latimeria chalumnae ------------------CCUGGUUGAUCCUG-CCAGUAG-CAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAUGUCUAAGUACAAACGGU-------------------GC---G-U -----------------------ACA-GU--GA-AAC-U-GCG-AAUGGCUCAUUAAAUC AGUUAUGGU-UCCUUUGAUC-GCUCCAACGUU---------ACUCGG--AUAACUG--U- G-GUAAUUCUAGAGCUAAUACAUGCCGACG-AGCGCU---G---------------A-CC ---UU-----------------------------------CGG----GG----------A ----UGCGU---GCAUUUAUCAGACC---AAAAC-C-AAU--------C-CGGG------ ------------UC----C------------------------G--CC-CGGCC-GCU-U U-GGU-GA-CUCUAGAUAACCUCGGGCCGA--UCGCACG-UC---------------C-U C-G-U--------------GGCGGCGACGAUUCCUUCGAAUGUCUG-CCCUAUCA-ACUU UCGAUGGUACUUUCUGUGCCUA-CCAUGGUGACCACGGGUAACGGGGAAUCAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCACUCCCG--AC----GCGGGGAGGUAGUGACGAAAAAUAACAAUACAGG-AC UC--UU-UC--GAGGCCC-UGUAAUUGGAAUGAGUACACUU--------------UAA-A U-C-----------------CUUUAACGAGGAUCUAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAGUAGCGUAUAUUAAAGUUGCUGCAGUUAAAAAGCUC GUAGUUGGAUCUUGGGAUCG-AGCU-G-G-CGG-UCCGCC-------------------- -GCGA----------------------------G-GC-GA---GCUACCGCCUGUCCCAG CCCCUGCC----------------UCUUGGCG---------------------------- ------------------------------------------------------------ ---------------------CUCC-CUUGA-UGCUC-UUAACU-GAGU--GUCC-UG-- -----GG-GG--------UCCGA-AGCG-UUUACUUUGAAAAAAUUAGAGUGUUCAAAGC AGGC-----CG---GUC------G-C--U--UGGAU-ACU-UCAGCUAGGAAUAAUGGAA UAGGA----------CU-C--CGGUUCU--A-UU-UU-GUU-GGUU-----UUCGGA-AC --U-GGG-GCC------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAG-AGGGACGGCC G-GGGGCAUUCGUA-UUGUGCCGCUAGAGGUGAAAUUCUUGGACCGGCGCAAGACGGACA AAAGCGAAAGCAUUUGCCAAGAAUGUUUUCAUUAAUCAAGAACGAAAGUCGGAGGUUCGA AGACGAUCAGAUACCGUC-GUAGUUCCGACCAUAAACGAUGC-CAACUACCGAUCCGGCG GCGUU------------------------------------------------------- -AUUUCCAU--------------------------------------------------- -------------------GACCCGCCGGGCAGGUUCCGGGAAACC-A--AAGUC----- ---UUUGGGUU-CCGGGGGGAGUAUGG-UUGCAAAGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACCCAACACGGGAAA-CCUC- A-CCC-GGC-CC-GGACACGG-AAA-GGAUUGA-CAGAUUGAUAGC-UCUU-U-CUCGA- --------------------UUCU-GUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GCGAUUUGUCUGGUUAAUUCCGAUAACGAACGAGACUCC-UCCAUGCUAAAUAGUUA CGCGACC----------------------------------------------------- ------------------------------------------------------------ ---------------CC-G---AGU----------------------------------- ------------------------------------------------------------ -----------------------------------------------G-GU-C-----G- --G-C--G-UCC--AACUUCUUAGAGGGACA-AGUG-A----CGU-UUAGC-CA-CACGA -G-AUUGAGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUCCGGGGCUGCACGCGCGCUAC ACUG-AAUGGAUCAGCGUGU-------------------------------GUC------ ---------------------UACCCUACACCGACAGGUGCGGGUAACCCGU--UGAACC CCA-UUCGUGAUAGGGAUCGGGGAUUGCAAUUAUUUCCCGUG-AACGAGGAAUUCCCAGU AAGUGCGG-GUCAUA-AGCUCGCGUUGAUUAAGUCCCUGCCCUUUGUACACACCGCCCGU CGCUACUACCGAUUGGAUGGUU-UAGUGAGGUCCUC-GGAUC-GGACC-CG-CC-GGGG- UCG-U-C-CG---CGG-CCCUGGCG-GAGCG-CUGAGAAG----------ACGAUCAAAC UUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAG- ---------------------- >Leishmania_major ----------------GAUCUGGUUGAUUCUG-CCAGUAGUCAU-AUGCUUGUUUC-A-A GGACUUAGCCAUGCAUGCCUCAGAAUCACUG---------------------CA---U-U -----------------------UGC-AG--GA-AUC-U-GCG-CAUGGCUCAUUACAUC AGACGUAAU-CUGCCGCAAA-AAUCUUGCGGUUUCCGCAA-AAUUGG--AUAACUU--G- G-CGAAACGCCAAGCUAAUACAUGAACCAACCGGGUGUU-CUCCACUCCA-GACGG-UGG --------------------GCA-A----------------------CCAUCGUCGUGA- --GACGCCC---AGCGAAUGAAUGACAGUAAAAC-C-AAUGCCUUC-AC-UGG------- ----------------CAGUA-ACAC---------------------C-CAG---CAG-U --GUU-GACUCAAUUCAUUCCGUG-CG-AA--AGCCGGC-UU---------------G-U U-C-C------------------GGCGUCUUUUGA-CGAACAACUG-CCCUAUCA-GCUG GUGAUGGCCGUGUAGUGGACUG-CCAUGGCGUUGACGGGAG-CGGGGGAUUAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAAUAGCUACCACUUCUACGG-AGGGCAGCAGGCGCGCA AAUUGCCCAAUGUCA-AAACAAAACGAUGAGGCAGCGAAAAGAAAUAGAGUUGUCAG-UC C---AU-UU---GGA-UU-GUCA-UUUCAAUGGGGGAUAUU--------------UAA-A CCCA------------U-C-CAAUAUCGAGUAACAAUUGGAGGACAA-GUC-UGGUGCCA GCACCCGCGGUAAUUCCAGCUCCAAAAGCGUAUAUUAAUGCUGUUGCUGUUAAAGGGUUC GUAGUUGAACUGUGGGCUGU-GCAG-GU--UUGUUCCUGGUCGUCCCGUCC--------- --AUGUC----------------GGAUUUGGU-G-A-CC----CAGGCCCUUGCAGCCCG UGAACAUUCAAAGAAACAAGA---AACACGGG--AGUGG--------------------- --------------------------------------------------UUCC------ -----------UUUCC--UGA---UU-U-ACG-CAUG-U--CAU-GCAU--GCCA--G-- -----GGG---GCG----UCCGU-GAUUUUUUACUGUGACUAAAGAAGCGUGACUAAAGC AGUC------A--UUU-------G-A--C-UUGAAU-UAG-AAAGCAUGGGAUAACAAAG GAGCAGCCUCUAGG-CU-ACCGUUUCGG--C-UU-UU-GUU-GGUU-----UUAAAG-GU CUA-UUG-G-AGAUUAUGGAGCUGUGCGACAAGUGCUUUCCCAUCGCA---AC------U UCG------GUUCGGUGUGUGGCGCCUUUGAGGGGUUUAGUGCGUCCGGUGCGAGCUCCG GUUCGUCCGGCCGUAACGCCUUUUCAACUCACGGCCUCUAGGAAUGAAGGAGGGUAGUUC G-GGGGAGAACGUA-CUGGGGCGUCAGAGGUGAAAUUCUUAGACCGCACCAAGACGAACU ACAGCGAAGGCAUUCUUCAAGGAUACCUUCCUCAAUCAAGAACCAAAGUGUGGAGAUCGA AGAUGAUUAGAGACCAUU-GUAGUCCACACUGCAAACGAUGA-CACCCAUGAAUUGGGGA UCUUAUGGGCCGGCCUGCGGCAGGGUUUACCCUGUGUCAGCACCGCGCCCGC-------- --UUUUAC-------------CAACUUACGUAUCUUUUCUAUUCGGCCUUUACCGGCCAC CCACGGGAAUAUCCUCAGCACGUUUUCUGUUUUUUCACGCGAAAGCUUU-GAGGU----- ---UACAGUCU-CAGGGGGGAGUACGU-UCGCAAGAG-UGAAACUUAAAGAAAUUGACGG AAUGGCACCACAA-GACGUGGAGCGUGCGGUUUAAUUUGACUCAACACGGGGAA-CUUU- A-CCA-GAU-CC-GGACAGGA-UGA-GGAUUGA-CAGAUUGAGUGU-UCUU-U-CUCGA- --------------------UUCC-CUGA-AUGGUGGUGCAUGGCCGCUUUUGGUCGGUG GA-GUGAUUUGUUUGGUUGAUUCCGUCAACGGACGAGAUCCA-AGC-UGCCCAGUAGAAU UCAGAAUUGCCCAUAGAAUAGCAAACU--CA-UCGGCGGGU------------------- ------------------------------------------------------------ ----------------U-UU---------------------------------------- ------------------------------------------------------------ ------------------------A--C-CCAACGGUG-GG-CCG-CA-UU-C------G G-UCG----AA---UUCUUCUCUGCGGGAUUCCUUU-G---UAAU-UGCAC-AA-GGUGA AAUUUUGGGCAACAGCAGGUCUGUGAUGCUCCUCAAUGUUCUGGGCGACACGCGCACUAC AAUG-UCAGUGAGAACAAG--------AAAAA-------------------CGAC----- ----------UUUUGUCGAACCU-ACUUGAUCAAAAGAGUGGGGAAACCCCG-GAAUCAC AUA-GACCCACUUGGGACCGAGGAUUGCAAUUAUUGGUCGCGCAACGAGGAAUGUCUCGU AGGCGCAG-CUCAUC-AAACUGUGCCGAUUACGUCCCUGCCAUUUGUACACACCGCCCGU CGUUGUUUCCGAU-GAUGGUGC-AAUACAGGUGAUC-GGACA-GGCGG-UG--------- ----U-UU-U-------------AU-C-C-G-CCCGAAAG----------UUCACCGAUA UUUCUUCAAUAGAGGAAGCAAAAGUCGUAACAAGGUAGCUGUAGGUGAACCUGCAGCUGG AUCAUUUU-------------- >Monodelphis_domestica ------------------CCUGGUUGAUCCUGCCCAGUAG-CAU-AUGCUUGUCUCAA-A AGAUUAAGCCAUGCAUGUCUAAGUACACACGGC-------------------CG---G-U -----------------------ACA-GU--GA-AAC-U-GCGAAAUGGCUCAUUAAAUC AGUUAUGGU-UCCUUUGGUC-GCUCGCUCCCUCCUA-----CUUUGG--AUAACUG--UG G-GUAAUUCUAGAGCUAAUACAUGCCGACG-AGCGCU---G---------------A-CC ---CGGGCCCCCUUCCCC--CUC-GCGGGUGGGGGGCCCCCGG----GG----------A ----UGCGU---GCAUUUAUCAGACC---AAAAC-C-AAC--------C-CCGGC-GGCU UC-C-CCCCAACCC----CCC-A---ACCAGGGGCCGGGGGUGC--CC-CGGCC-GCU-U U-GGU-GACUCUAGAUAACCCUCGGGCCGA--UCGCACG-CC---------------C-C CCG-U--------------GGCGGCGAUGACCCAUUCGAACGUCUGCCCCUAUCA-ACUU UCGAUGGUACUUGCCGUGCCUACCCAUGGUGACCACGGGUGACGGGGAAUCAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCACUCCCG--AC----CCGGGGAGGUAGUGACGAAAAAUAACAAUACAGG-AC UCU-UU-UC--GAGGCCC-UGUAAUUGGAAUGAGUACACUU--------------UAA-A U-C-----------------CUUUAACGAGGAUCCAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGCUGCAGUUAAAAAGCUC GUAGUUGGAUCUUGGGAUCG-AGCU-G-G-CGG-UCCGCC-------------------- -GCGA----------------------------G-GC-GA---GCCACCGCCUGUCCCAG CCCCUGCCU---------------UCUCGGCG---------------------------- ------------------------------------------------------------ ---------------------CCCC-CUCGA-UGCUCUUUAGCU-GAGU--GUCC-CGC- -----GG-GG--------CCCGA-AGCGUUUUACUUUGAAAAAAUUAGAGUGUUCAAAGC AGGC----CCG--AGUC------GCC--C--UGGAU-ACC-CCAGCUAGGAAUAAUGGAA UAGGA----------CC-C--CGGUUCU--AUUU-UU-GUU-GGUU-----UUCGGA-AC --U-GGG-GCC------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAG-AGGGACGGCC G-GGGGCAUUCGUAUUUGUGCCGCUAGAGGUGAAAUUCUUGGACCGGCGCAAGACGGACC AGAGCGAAAGCAUUUGCCAAGAAUGUUUUCAUUAAUCAAGAACGAAAGUCGGAGGUUCGA AGACGAUCAGAUACUCGUCGUAGUUCCGACCAUAAACGAUGCUCGACUAGCGAUCCGGCG GCGUU------------------------------------------------------- -AUUCCCAU--------------------------------------------------- ------------------GACCCCGCCGGGCAGCUUCCGGGAAACC-A--AAGUC----- ---UUUGGGUU-CCGGGGGGAGUAUGGGUUGCAAAGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGAAAUCCUC- A-CCCGGGC-CC-GGACACGG-AAA-GGAUUGA-CAGAUUGAUAGCUUCUU-U-CUCGA- --------------------UUCU-GUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GCGAUUUGUCUGGUUAAUUCCGAUAACGAACGAGACUCU-GGCAUGCUAACUAGUUA CGCGACC----------------------------------------------------- ------------------------------------------------------------ ---------------CC-CGUUAGU----------------------------------- ------------------------------------------------------------ -----------------------------------------------G-GU-C-----G- --G-U--C-GUCCCAACUUCUUAGAGGGACA-AGUG-G----CGU-UCAGCGCA-CCCGA -G-AUUGAGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUCCGGGGCUGCACGCGCGCUAC ACUG-ACUGGCUCAGCGUGU-------------------------------GCC------ ---------------------UACCCUACGCCGGCAGGCGCGGGUAACCCGU--UGAACC CCA-UUCGUGAUGGGGAUCGGGGAUUGCAAUUAUUCCCCAUG-AACGAGGAAUUCCCAGU AAGUGCGG-GUCAUA-AGCUUGCGUUGAUUAAGUCCCUGCCCUUUGUACACACCGCCCGU CGCUACUACCGAUUGGAUGGUU-UAGUGAGGUCCUC-GGAUC-GGCCC-CG-CC-GGGG- UCG-G-CCCA---CGG-CCCUGGCG-GAGCG-CUGAGAAG----------ACGGUCGAAC UUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAG- ---------------------- >Mus_musculus ----------------UACCUGGUUGAUCCUG-CCAGUAG-CAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAUGUCUAAGUACGCACGGC-------------------CG---G-U -----------------------ACA-GU--GA-AAC-U-GCG-AAUGGCUCAUUAAAUC AGUUAUGGU-UCCUUUGGUC-GCUCGCUCCUCUCCU-----ACUUGG--AUAACUG--U- G-GUAAUUCUAGAGCUAAUACAUGCCGACG-GGCGCU---G---------------A-CC ---CC---------CCUU--CCC---GGG-----------GGG----GG----------A ----UGCGU---GCAUUUAUCAGAUC---AAAAC-C-AAC--------C-CGGUG-AGCU CC-C-UCCCGG--C----UCC-G---GCCGGGGGUCGG----GC--GC-CGGCG-GCU-U U-GGU-GA-CUCUAGAUAACCUCGGGCCGA--UCGCACG-CC---------------C-C CCG-U--------------GGCGGCGACGACCCAUUCGAACGUCUG-CCCUAUCA-ACUU UCGAUGGUAGUCGCCGUGCCUA-CCAUGGUGACCACGGGUGACGGGGAAUCAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCACUCCCG--AC----CCGGGGAGGUAGUGACGAAAAAUAACAAUACAGG-AC UC--UU-UC--GAGGCCC-UGUAAUUGGAAUGAGUCCACUU--------------UAA-A U-C-----------------CUUUAACGAGGAUCCAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGCUGCAGUUAAAAAGCUC GUAGUUGGAUCUUGGGAGCG-GGCG-G-G-CGG-UCCGCC-------------------- -GCGA----------------------------G-GC-GA---GUCACCGCCCGUCCCCG CCCCUUGCC---------------UCUCGGCG---------------------------- ------------------------------------------------------------ ---------------------CCCC-CUCGA-UGCUC-UUAGCU-GAGU--GUCC-CGC- -----GG-GG--------CCCGA-AGCG-UUUACUUUGAAAAAAUUAGAGUGUUCAAAGC AGGC----CCG--AGCC------G-C--C--UGGAU-ACC-GCAGCUAGGAAUAAUGGAA UAGGA----------CC-G--CGGUUCU--A-UU-UU-GUU-GGUU-----UUCGGA-AC --U-GAG-GCC------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAG-AGGGACGGCC G-GGGGCAUUCGUA-UUGCGCCGCUAGAGGUGAAAUUCUUGGACCGGCGCAAGACGGACC AGAGCGAAAGCAUUUGCCAAGAAUGUUUUCAUUAAUCAAGAACGAAAGUCGGAGGUUCGA AGACGAUCAGAUACCGUC-GUAGUUCCGACCAUAAACGAUGC-CGACUGGCGAUGCGGCG GCGUU------------------------------------------------------- -AUUCCCAU--------------------------------------------------- -------------------GACCCGCCGGGCAGCUUCCGGGAAACC-A--AAGUC----- ---UUUGGGUU-CCGGGGGGAGUAUGG-UUGCAAAGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGAAA-CCUC- A-CCC-GGC-CC-GGACACGG-ACA-GGAUUGA-CAGAUUGAUAGC-UCUU-U-CUCGA- --------------------UUCC-GUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GCGAUUUGUCUGGUUAAUUCCGAUAACGAACGAGACUCU-GGCAUGCUAACUAGUUA CGCGACC----------------------------------------------------- ------------------------------------------------------------ ---------------CC-CG--AGC----------------------------------- ------------------------------------------------------------ -----------------------------------------------G-GU-C-----G- --G-C--GUCCCCCAACUUCUUAGAGGGACA-AGUG-G----CGU-UCAGC-CA-CCCGA -G-AUUGAGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUCCGGGGCUGCACGCGCGCUAC ACUG-ACUGGCUCAGCGUGU-------------------------------GCC------ ---------------------UACCCUACGCCGGCAGGCGCGGGUAACCCGU--UGAACC CCA-UUCGUGAUGGGGAUCGGGGAUUGCAAUUAUUCCCCAUG-AACGAGGAAUUCCCAGU AAGUGCGG-GUCAUA-AGCUUGCGUUGAUUAAGUCCCUGCCCUUUGUACACACCGCCCGU CGCUACUACCGAUUGGAUGGUU-UAGUGAGGCCCUC-GGAUC-GGCCC-CG-CC-GGGG- UCG-G-CCCA---CGG-CCCUGGCG-GAGCG-CUGAGAAG----------ACGGUCGAAC UUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUA--------------- >Oryza_sativa ----------------UACCUGGUUGAUCCUG-CCAGUAGUCAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAUGUGCAAGUAUGAACUAAU------------------UC---G-A -----------------------ACU-GU--GA-AAC-U-GCG-AAUGGCUCAUUAAAUC AGUUAUAGU-UUGUUUGAUG-GUACGUGCU-----------ACUCGG--AUAACCG--U- A-GUAAUUCUAGAGCUAAUACGUGCAACA--AACCCC---G---------------A-CU ---------------------UC-C----------------------GG----------G A---GGGGC---GCAUUUAUUAGAUA--AAAGGC-U-GAC--------G-CGGGC----- ------------------UCC------------------------GCC-CGCUG-AUC-C --GAU-GA-UUCAUGAUAACUCGA-CG-GA--UCGCACG-GC---------------C-C UCG-U--------------GCCGGCGACGCAUCAUUCAAAUUUCUG-CCCUAUCA-ACUU UCGAUGGUAGGAUAGGGGCCUA-CCAUGGUGGUGACGGGUGACGGAGAAUUAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCAAUCCUG--AC----ACGGGGAGGUAGUGACAAUAAAUAACAAUACCGG-GC GC--UU-UA--GUGU-CU-GGUAAUUGGAAUGAGUACAAUC--------------UAA-A U-C-----------------CCUUAACGAGGAUCCAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUUAAGUUGUUGCAGUUAAAAAGCUC GUAGUUGGACCUUGGGCCGG-GCCG-G-C-CGG-UCCGCC-------------------- -UCAC----------------------------G-GC-G----AGCACCGACCUGCUCGA CCCUU-------------------CUGCCGGCG--------------------------- ------------------------------------------------------------ ---------------------AUGC-GCUCC-UGGCC-UUAACU-GGCC--GGGU--C-- -----GU-GCC------UCCGGC-GC-C-GUUACUUUGAAGAAAUUAGAGUGCUCAAAGC AAGC------C--AUC-------G-C--U-CUGGAU-ACA-UUAGCAUGGGAUAACAUCA UAGGA----------UU-C--CGGUCCU--A-UU-GU-GUU-GGCC-----UUCGGG-AU --C-GGA-GUA------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAU-AGGGACAGUC G-GGGGCAUUCGUA-UUUCAUAGUCAGAGGUGAAAUUCUUGGAUUUAUGAAAGACGAACA ACUGCGAAAGCAUUUGCCAAGGAUGUUUUCAUUAAUCAAGAACGAAAGUUGGGGGCUCGA AGACGAUCAGAUACCGUC-CUAGUCUCAACCAUAAACGAUGC-CGACCAGGGAUCGGCGG AUGUU------------------------------------------------------- -GCUUAUAG--------------------------------------------------- -------------------GACUCCGCCGGCACCUUAUGAGAAAUC-A--AAGUC----- ---UUUGGGUU-CCGGGGGGAGUAUGG-UCGCAAGGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGCGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGGAA-ACUU- A-CCA-GGU-CC-AGACAUAG-CAA-GGAUUGA-CAGACUGAGAGC-UCUU-U-CUUGA- --------------------UUCU-AUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GCGAUUUGUCUGGUUAAUUCCGUUAACGAACGAGACCUC-AGCCUGCUAACUAGCUA UGCGGAGC---------------------------------------------------- ------------------------------------------------------------ ----------------C-AU--C------------------------------------- ------------------------------------------------------------ --------------------------------------------C--C-UC-C------- --G-C--A-GCU--AGCUUCUUAGAGGGACU-AUGG-C----CGU-UUAGG-CC-ACGGA AGUUUGAGGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUUCUGGGCCGCACGCGCGCUAC ACUG-AUGUAUCCAACGAGU-------------------------------AUAUA---- ----------------------G-CCUUGGCCGACAGGCCCGGGUAA-UCUU-GGGAAAU UUC-AUCGUGAUGGGGAUAGAUCAUUGCAAUUGUUGGUCUUC-AACGAGGAAUGCCUAGU AAGCGCGA-GUCAUC-AGCUCGCGUUGACUACGUCCCUGCCCUUUGUACACACCGCCCGU CGCUCCUACCGAUUGAAUGGUC-CGGUGAAGUGUUC-GGAUC-GCGGC-GA-CG-GGGG- CGG-U-UC-G---CCG-CCCCCGAC-G-U-C-GCGAGAAG----------UCCAUUGAAC CUUAUCAUUUAGAGGAAGGAGAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUG--------------- >Pan_troglodytes ----------------UACUUGGUUGAUCCUA-CCAGUAC-CAU-AUGCUUGUCUC-A-A AGAUUAUGCCAUACAUGUCUAAGUAGGCAGGGC-------------------CG---G-U -----------------------ACA-GU--GA-AAC-U-ACG-AAUGGCUCAUUAAAUC AGUUAUGGU-UCUUUUGGUC-GCUCGCUCCUCUCCU-----ACUUGG--AAAACUG--U- G-GUAAUUCUAGAGCUAAUGCAUGCCGAAG-GGCGCU---G---------------A-CC ---CC---------C-UU----C-G--CG-----------GGGA---AG----------A ----UGCCU---GCAUUUAUCAGAUC---AAAAC-C-AAC--------C-CGGUC-AGCC CC-U-CUCCAG--C----CCCUG---CCCAGGGGUCGA----G--UGC-CACCG-GCU-U U-GGU-GA-CUCUAGAUAGCCUCGGGCCAA--UCGCACG-CC---------------CGC CCG-U--------------GGCAGCAACGACCCAUUCGAACGUCUG-CCCUCUCA-ACUU UUGAUGGUAGUCACUGUGCCUA-CCAUGGUGACCACGGGUGA---AGAAUCAGGGUUC-G AUUCUGGAGAGGGAGCCUGAGAAAUGGCUACCACAUUCAAGG-AAGGCAGCAGGCAUGCA AAUUACCCACUCCUG--AC----CCAAGGAGAUAGUGAUGAAACAUAAUAAUACAGG-AC UC--UU-UU--GAGGUCC-UGUAAUUGGAAUGAGUCUACUU--------------UAA-A U-C-----------------CUUUAACGAAGAUCCAUUGGAGGGCAA-GUC-UAGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGCUGCAGUUAAAAAGCUC CUAGUUGGAUCUUGGGAGUG-GGCG-G-G-CGG-UCCGCC-------------------- -AUGA----------------------------G-GC-GA---GCCACUGCCCGUCCCCG CCCCUUGCC---------------UCUUGGCA---------------------------- ------------------------------------------------------------ ---------------------CCCC-CUCGA-UGCUC-UUAGCU-GAGU--GUUC-UGC- -----GG-----------CCCAA-AGCG-UCUACUUUGAAAAAAUUAGAGUGUUCAAAGC AGGU----CCG--AGCC------G-C--C--UGGAU-ACC-GCAGCUAGGAAUAAUGGAA UAGGA----------CC-G--UGGUUCU--A-UU-UU-GCU-GGUU-----UUCGGA-AC --U-GAG-GCC------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAG-AGGGACAGCU G-GGGGCAUUUGUA-UUGCACCGCUAGAGGUGAAAUUCUUGGACUGGCACAGUUUGGACC AGAGUGAAAGCAUUUGCCAAGAAUGUUUUCAUUAAUCAAGAACGAAAGUCGGAGGUUCGA AGACGAUCAGAUACCGUG-GUAGUUCUGUCCAUAAACGAAGC-CGACUGGCAACGUGGCG GUGUU------------------------------------------------------- -AUUCCCAU--------------------------------------------------- -------------------GACCCGCUGGGCAGCUUCCAAGAAACC-A--AAGUCUUUGC GUUUUUAGGUU-CCGGGGGGAGUAUGG-UUGCAAAGC-UGAAACUUAAAGGAAUUGGUGG AAGGGCAACACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACUCAACAUGGGAAA-AAUC- A-CCC-GAC-CC-AGACAGGG-ACC-UGAUUGA-CAGAUUGAUAGC-UAUU-U-CUCUG- --------------------UUCC-AUGG-GUGGUGGUGCAUGGC----CUUAGUUGGUG GA-GUGAUUUGUCUCGUUAAUUCCGAUAACCAACGAGACUCU-GGCAUGCUAACUAGUUA CGUGACC----------------------------------------------------- ------------------------------------------------------------ ---------------CC-CG--AGC----------------------------------- ------------------------------------------------------------ -----------------------------------------------G-GU-C-----A- --G-C--AUCCCCCAACUUCUUAGAGGGACA-AGUG-G----CCU-UCAGC-CA-CCCGA A--AUUGAGCAAUAACAGAUCUGUGAUGCCCUUAGAUGUCCGGGACUGCACGCGCGCUAC ACUG---CUGCUCAGCGUGU-------------------------------GCC------ ---------------------UACCCUACGU-GGCAGAGGCAGGUAACCUGU--UGAACC CCA-UUCGUGAUGGGGAUGGGGGAUUGCAAUUAUUCCCCAUG-AAGGAGGAAUUUCCAGU AAGUGCGG-GUCAUA-AGCUUGCCU-GAA---GUCCCUGCCCUAUGUACACACUGCCCGC CUCUACUACUGAUAGGAUGGUU-UAGUGAGGCCCUC-UGAUC-AGC-C-CU-GC-CGGG- UCA-G-CCCA---CUG-CCCUGGCG-GAGCG-CUGAGAAG----------ACAGUCGAAC UUGACUAUCUAGAGGAAGUAAAAUUCGUAACAAGGUUUCGGUAGGUGAACCUGCGGAGGG AUCAUUA--------------- >Plasmodium_falciparum ----------------AACCUGGUUGAUCUUG-CCAGUAGUCAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAAGUGAAAGUAUAUAUAUA-------------------UU---U-U -----------------------AUAUGUA-GA-AAC-U-GCG-AACGGCUCAUUAAAAC AGUUAUAGU-CUACUUGACA-UUUUUAUU------------AUAAGG--AUAACUA--C- G-GAAAAGCUGUAGCUAAUACUUGCUUU---AUUAUCCUU-U---------------GAU --------------------UUU-U----------------------AUC--------U- -UUGGAUAA---GUAUUUGUUAGGCC------UUAU-AAGAAAA----A----------- -----------------AGUU-A---------------------------UU--A-AC-U U-AAG-GA-AUUAUAACAAAGAAGUAA-CA--CGUAAUA-A-----------AU---U-U A-U-UUU------------AUUUAGUGUGUAUCAAUCGAGUUUCUG-ACCUAUCA-GCUU UUGAUGUUAGGGUAUUGGCCUA-ACAUGGCUAUGACGGGUAACGGGGAAUUAGAGUUC-G AUUCCGGAGAGGGAGCCUGAGAAAUAGCUACCACAUCUAAGG-AAGGCAGCAGGCGCGUA AAUUACCCAAUUCUA--AA----GAAGAGAGGUAGUGACAAGAAAUAACAAUGCAAG-GC CA--AUUUU--UGGU-UU-UGUAAUUGGAAUGGUGGGAAUU--------------UAA-A A-C-----------------CUUCCCAGAGUAACAAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAAUUGUUGCAGUUAAAACGCUC GUAGUUGAAUUUCAAAGAAU-CGAUAUUU-UAUUGUAACUAUUCUAGGGGAACUAUUUUA GCUUUUCGCUUUAAUACGCUUCCUCUAU--UA-UUA-UG----UUCUUUAAAUAACAAAG AUUCUUUU----------------UAAAAUC----------------------------- ------------------------------------------------------------ ------------------------C-C-CACUUUUGC--UUUU--GCUU--UUUUU-G-- -----GG-----------GAUUU--U---GUUACUUUGAGUAAAUUAGAGUGUUCAAAGC AAACAGUUAAAG-CAUUUACUGUG-U--U--UGAAU-ACU-AUAGCAUGGAAUAACAAAA UUGAA----------CA-A--GCUAAAA----UUUUUUGUUCUUUU--UUCUUAUUU-UG --G-CUUAGUU------------------------------------------------- ------------------------------------------------------------ ----------------------------------------ACGAUUAAU-AGGAGUAGCU UGGGGACAUUCGUA-UUCAGAUGUCAGAGGUGAAAUUCUUAGAUUUUCUGGAGACGAACA ACUGCGAAAGCAUUUGUCUAAAAUACUUCCAUUAAUCAAGAACGAAAGUUAAGGGAGUGA AGACGAUCAGAUACCGUC-GUAAUCUUAACCAUAAACUAUGC-CGACUAGGUGUUGGAUG AAAGUGUUAAAAAUAAAAGUCAUC------------------------------------ --UUUCGA---------------------------------------------------- ----GGUGACUUUUAGAUUGCUUCCUUCAGUACCUUAUGAGAAAUC-A--AAGUC----- ---UUUGGGUU-CUGGGGCGAGUAUUC-GCGCAAGCG-AGAAAGUUAAAAGAAUUGACGG AAGGGCACCACCA-GGCGUGGAGCUUGCGGCUUAAUUUGACUCAACACGGGGAA-ACUC- A-CUA-GUU-UA-AGACAAGA-GUA-GGAUUGA-CAGAUUAAUAGC-UCUU-U-CUUGA- --------------------UUUC-UUGG-AUGGUGAUGCAUGGCCGUUUUUAGUUCGUG AAUAUGAUUUGUCUGGUUAAUUCCGAUAACGAACGAGAUCUUAACCUGCUAAUUAGCGGC GAGUACAC--------UAUA--------UU-CUUAUUUGAAAUUGAACAUAGGUAACUAU ACAUUUAUUCAGUAAUCAAAUUAGGAUAUUUU---------------------------- ---------------U-AU--U-------------------------------------- -----------AAAAUAUCCUUUUCCCUGUUCUACUAAUAAUUUGUUUUUUACUCUAUUU CU---------CUC--------UU--C-UUUUAAGAA-UGUAC----U-UG-C------- -UU-G--AUUGAAAAGCUUCUUAGAGGAACA-UUGU-G----UGU-CUAAC-AC-AAGGA AGUUUAAGGCAACAACAGGUCUGUGAUGUCCUUAGAUGAACUAGGCUGCACGCGUGCUAC ACUG-AUAUAUAUAACGAGU-UUUUA-AAAAUAUGCUUAUAUUUGUAUC--UUU-GAUGC UUAUAUUUUGCAUACUUU----U-CCUCCGCCGAAAGGCGUAGGUAA-UCUUUAUCAAUA UAU-AUCGUGAUGGGGAUAGAUUAUUGCAAUUAUUAAUCUUG-AACGAGGAAUGCCUAGU AAGCAUGA-UUCAUC-AGAUUGUGCUGACUACGUCCCUGCCCUUUGUACACACCGCCCGU CGCUCCUACCGAUUGAAAGAUA-UGAUGAAUUGUUU-GGACA-AGAAA-AA-UU-GAA-- U---U-AU-A--------UUCUUUU-U-U-U-UCUGGAAA----------AACCGUAAAU CCUAUCUUUUAAAGGAAGGAGAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUA--------------- >Rattus_norvegicus ----------------UACCUGGUUGAUCCUG-CCAGUAG-CAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAUGUCUAAGUACGCACGGC-------------------CG---G-U -----------------------ACA-GU--GA-AAC-U-GCG-AAUGGCUCAUUAAAUC AGUUAUGGU-UCCUUUGGUC-GCUCGCUCCUCUCCU-----ACUUGG--AUAACUG--U- G-GUAAUUCUAGAGCUAAUACAUGCCGACG-GGCGCU---G---------------A-CC ---CC---------CCUU--CCC-G--UG-----------GGG----GG----------A A---CGCGU---GCAUUUAUCAGAUC---AAAAC-C-AAC--------C-CGGUC-AGCC CC-C-UCCCGG--C----UCC-G---GCCGGGGGUCGG----GC--GC-CGGCG-GCU-U U-GGU-GA-CUCUAGAUAACCUCGGGCCGA--UCGCACG-UC---------------C-C C-G-U--------------GGCGGCGACGACCCAUUCGAACGUCUG-CCCUAUCA-ACUU UCGAUGGUAGUCGCCGUGCCUA-CCAUGGUGACCACGGGUGACGGGGAAUCAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCACUCCCG--AC----CCGGGGAGGUAGUGACGAAAAAUAACAAUACAGG-AC UC--UU-UC--GAGGCCC-UGUAAUUGGAAUGAGUCCACUU--------------UAA-A U-C-----------------CUUUAACGAGGAUCCAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGCUGCAGUUAAAAAGCUC GUAGUUGGAUCUUGGGAGCG-GGCG-G-G-CGG-UCCGCC-------------------- -GCGA----------------------------G-GC-GA---GCUCACCGCCCUGUCCC CAGCCCCUGCC-------------UCUCGGCG---------------------------- ------------------------------------------------------------ ---------------------CCCC-CUCGA-UGCUC-UUAGCU-GAGU--GUCC-CGC- -----GG-GG--------CCCGA-AGCG-UUUACUUUGAAAAAAUUAGAGUGUUCAAAGC AGGC----CCG--AGCC------G-C--C--UGGAU-ACC-GCAGCUAGGAAUAAUGGAA UAGGA----------CC-G--CGGUUCU--A-UU-UU-GUU-GGUU-----UUCGGA-AC --U-GAG-GCC------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAG-AGGGACGGCC G-GGGGCAUUCGUA-UUGCGCCGCUAGAGGUGAAAUUCUUGGACCGGCGCAAGACGAACC AGAGCGAAAGCAUUUGCCAAGAAUGUUUUCAUUAAUCAAGAACGAAAGUCGGAGGUUCGA AGACGAUCAGAUACCGUC-GUAGUUCCGACCAUAAACGAUGC-CGACUGGCGAUGCGGCG GCGUU------------------------------------------------------- -AUUCCCAU--------------------------------------------------- -------------------GACCCGCCGGGCAGCUUCCGGGAAACC-A--AAGUC----- ---UUUGGGUU-CCGGGGGGAGUAUGG-UUGCAAAGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGAAA-CCUC- A-CCC-GGC-CC-GGACACGG-ACA-GGAUUGA-CAGAUUGAUAGC-UCUU-U-CUCGA- --------------------UUCC-GUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GCGAUUUGUCUGGUUAAUUCCGAUAACGAACGAGACUCUCGGCAUGCUAACUAGUUA CGCGACC----------------------------------------------------- ------------------------------------------------------------ ---------------CC-CG--AGC----------------------------------- ------------------------------------------------------------ -----------------------------------------------G-GU-C-----G- --G-C--GUCCCCCAACUUCUUAGAGGGACA-AGUG-G----CGU-UCAGC-CA-C-CGA -G-AUUGAGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUCCGGGGCUGCACGCGCGCUAC ACUGAACUGGCUCAGCGUGU-------------------------------GCC------ ---------------------UACCCUACGCCGGCAGGCGCGGGUAACCCGU--UGAACC CCA-UUCGUGAUGGGGAUCGGGGAUUGCAAUUAUUCCCCAUG-AACGAGGAAUUCCCAGU AAGUGCGG-GUCAUA-AGCUUGCGUUGAUUAAGUCCCUGCCCUUUGUACACACCGCCCGU CGCUACUACCGAUUGGAUGGUU-UAGUGAGGCCCUC-GGAUC-GGCCC-CG-CC-GGGG- UCG-G-CCCA---CGG-CCUUGGCG-GAG-GCCUGAGAAG----------ACGGUCGAAC UUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUA--------------- >Saccharomyces_cerevisiae ----------------UAUCUGGUUGAUCCUG-CCAGUAGUCAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAUGUCUAAGUAUAAGCAAU-------------------UU---A-U -----------------------ACA-GU--GA-AAC-U-GCG-AAUGGCUCAUUAAAUC AGUUAUCGU-UUAUUUGAUA-GUUCCUUUACU---------ACAUGGU-AUAACUG--U- G-GUAAUUCUAGAGCUAAUACAUGCUUAA--AAUCUC---G---------------A-CC --------------------CUU-U----------------------GG----------A A---GAGAU---GUAUUUAUUAGAUA--AAAAAU-C-AAU--------G-UC-------- ------------------UUC-G--------------------------GACUC--UU-U --GAU-GA-UUCAUAAUAACUUUU-CG-AA--UCGCAUG-GC---------------C-U U-G-U--------------GCUGGCGAUGGUUCAUUCAAAUUUCUG-CCCUAUCA-ACUU UCGAUGGUAGGAUAGUGGCCUA-CCAUGGUUUCAACGGGUAACGGGGAAUAAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCAAUCCUA--AU----UCAGGGAGGUAGUGACAAUAAAUAACGAUACAGG-GC CC--AU-UC--GGGU-CU-UGUAAUUGGAAUGAGUACAAUG--------------UAA-A U-A-----------------CCUUAACGAGGAACAAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGUUGCAGUUAAAAAGCUC GUAGUUGAACUUUGGGCCCG-GUUG-G-C-CGG-UCCGAU-------------------- -UUU-----------------------------U-UC-G----UGUACUGGAUUUCCAAC GGGGCCUUUC--------------CUUCUGGCU--------------------------- ------------------------------------------------------------ ---------------------AACC-U---U-GAGUC--CUUGU-GGCU--CU----U-- -----GG-CGA------ACCAGG-AC-U-UUUACUUUGAAAAAAUUAGAGUGUUCAAAGC AGGC------GU-AUU-------G-C--U--CGAAU-AUA-UUAGCAUGGAAUAAUAGAA UAGGA----------CGUU--UGGUUCU--A-UU-UU-GUU-GGUU-----UCUAGG-AC --C-AUC-GUA------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAU-AGGGACGGUC G-GGGGCAUCAGUA-UUCAAUUGUCAGAGGUGAAAUUCUUGGAUUUAUUGAAGACUAACU ACUGCGAAAGCAUUUGCCAAGGACGUUUUCAUUAAUCAAGAACGAAAGUUAGGGGAUCGA AGAUGAUCAGAUACCGUC-GUAGUCUUAACCAUAAACUAUGC-CGACUAGGGAUCGGGUG GUGUU------------------------------------------------------- -UUUUUAAU--------------------------------------------------- -------------------GACCCACUCGGCACCUUACGAGAAAUC-A--AAGUC----- ---UUUGGGUU-CUGGGGGGAGUAUGG-UCGCAAGGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGGAA-ACUC- A-CCA-GGU-CC-AGACACAA-UAA-GGAUUGA-CAGAUUGAGAGC-UCUU-U-CUUGA- --------------------UUUU-GUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GUGAUUUGUCUGCUUAAUUGCGAUAACGAACGAGACCUU-AACCUACUAAAUAGUGG UGCUAGC----------------------------------------------------- ------------------------------------------------------------ ----------------A-UU--U------------------------------------- ------------------------------------------------------------ -----------------------------------------------G-CU-G-----GU UAU-C---------CACUUCUUAGAGGGACU-AUCG-G----UUU-CAAGC-CG-AUGGA AGUUUGAGGCAAUAACAGGUCUGUGAUGCCCUUAGACGUUCUGGGCCGCACGCGCGCUAC ACUG-ACGGAGCCAGCGAGU-------------------------------CUA------ ----------------------A-CCUUGGCCGAGAGGUCUUGGUAA-UCUU-GUGAAAC UCC-GUCGUGCUGGGGAUAGAGCAUUGUAAUUAUUGCUCUUC-AACGAGGAAUUCCUAGU AAGCGCAA-GUCAUC-AGCUUGCGUUGAUUACGUCCCUGCCCUUUGUACACACCGCCCGU CGCUAGUACCGAUUGAAUGGCU-UAGUGAGGCCUCA-GGAUC-UGCUU-AG-AG-AAGG- GG--G-CA-A----CU-CCAUCUCA-G-A-G-CGGAGAAU----------UUGGACAAAC UUGGUCAUUUAGAGGAACUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUA--------------- >Schizosaccharomyces_pombe ----------------UACCUGGUUGAUCCUG-CCAGUAGUCAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCAUGUCUAAGUAUAAGCAAUU------------------UU---G-U -----------------------ACU-GU--GA-AAC-U-GCG-AAUGGCUCAUUAAAUC AGUUAUCGU-UUAUUUGAUA-GUACCUCAACU---------ACUUGG--AUAACCG--U- G-GUAAUUCUAGAGCUAAUACAUGCUAAA--AAUCCC---G---------------A-CU --------------------UUUUU----------------------GG----------A A---GGGAU---GUAUUUAUUAGAUA--AAAAAC-C-AAU--------G-C-C------- ------------------UUC-G------------------------G--GCUUU-UU-U U-GGU-GA-GUCAUAAUAACUUUU-CG-AA--UCGCAUG-GC---------------C-U U-G-C--------------GCCGGCGAUGGUUCAUUCAAAUUUCUG-CCCUAUCA-ACUU UCGAUGGUAGGAUAGAGGCCUA-CCAUGGUUUUAACGGGUAACGGGGAAUUAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCAAUCCCG--AC----ACGGGGAGGUAGUGACAAGAAAUAACAAUGCAGG-GC CC--UU-UC--GGGU-CU-UGUAAUUGGAAUGAGUACAAUG--------------UAA-A U-A-----------------CCUUAACGAGGAACAAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGUUGCAGUUAAAAAGCUC GUAGUUGAACUUUGAGCCUG-GUCG-A-C-UGG-UCCGCC-------------------- -GCAAG---------------------------GCGU-G----UUUACUGGUCAUGACCG GGGUCGUU-------------AACCUUCUGGCA--------------------------- ------------------------------------------------------------ ---------------------AACU-ACUCA-UGUUC-UUUAUU-GAGC--GUGG--U-- -----AG-GGA------ACCAGG-AC-U-UUUACCUUGAAAAAAUUAGAGUGUUCAAAGC AGGCAA----G--UUU------UG-C--U--CGAAU-ACA-UUAGCAUGGAAUAAUAAAA UAGGA----------CGUG--UGGUUCU--A-UU-UU-GUU-GGUU-----UCUAGG-AC --C-GCC-GUA------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAU-AGGGAUAGUC G-GGGGCAUUCGUA-UUCAAUUGUCAGAGGUGAAAUUCUUGGAUUUAUUGAAGACGAACU ACUGCGAAAGCAUUUGCCAAGGAUGUUUUCAUUAAUCAAGAACGAAAGUUAGGGGAUCGA AGACGAUCAGAUACCGUC-GUAGUCUUAACCAUAAACUAUGC-CGACUAGGGAUCGGGCA AUGUU------------------------------------------------------- UCAUUUAUC--------------------------------------------------- -------------------GACUUGCUCGGCACCUUACGAGAAAUC-A--AAGUC----- ---UUUGGGUU-CCGGGGGGAGUAUGG-UCGCAAGGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACAAUGGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGGAA-ACUC- A-CCA-GGU-CC-AGACAUAG-UAA-GGAUUGA-CAGAUUGAGAGC-UCUU-U-CUUGA- --------------------UUCU-AUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GUGAUUUGUCUGCUUAAUUGCGAUAACGAACGAGACCUU-AACCUGCUAAAUAGCUG GAUCAGCC---------------------------------------------------- ------------------------------------------------------------ ---------------AU-UU--U------------------------------------- ------------------------------------------------------------ --------------------------------------------G--G-CU-G------- --A-U--C-AUU--AGCUUCUUAGAGGGACU-AUUG-G----CAU-AAAGC-CA-AUGGA AGUUUGAGGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUUCUGGGCCGCACGCGCGCUAC ACUG-ACGGAGCCAACGAGUUGA----AAAAAAUC---------------UUUU------ ----------GAUUUUUUA---U-CCUUGGCCGGAAGGUCUGGGUAA-UCUU-GUUAAAC UCC-GUCGUGCUGGGGAUAGAGCAUUGCAAUUAUUGCUCUUC-AACGAGGAAUUCCUAGU AAGCGCAA-GUCAUC-AGCUUGCGUUGAAUACGUCCCUGCCCUUUGUACACACCGCCCGU CGCUACUACCGAUUGAAUGGCU-UAGUGAGGCCUCU-GGAUU-GGCUU-GU-UU-CUGC- UG--G-CA-A----CG-GCGGAAACAU-U-G-CCGAGAAG----------UUGGACAAAC UUGGUCAUUUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUA--------------- >Tetrahymena_thermophila ----------------AACCUGGUUGAUCCUG-CCAGUUA-CAU-AUGCUUGUCUU-A-A AUAUUAACCCAUGCAUGUGCCAGUUCAGUA----------------------UU---G-A -----------------------ACA-GC--GA-AAC-U-GCG-AAUGGCUCAUUAAAAC AGUUAUAGU-UUAUUUGAUA-AUUAAAGAUU----------ACAUGG--AUAACCG--A- G-CUAAUUGUUGGGCUAAUACAUGCUUAAA-AUUCCG--------------------UGU ---------------------CC-U----------------------GCG---------A C--CGGAAC---GUAUUUAUUAGAUA--UUAGAC-C-AAU--------C-GCA------- ------------------GCA-A------------------------U-GUGA----U-U GAGAU-GA-AUCAAAGUAACUGAU-CG-GA--UCGAGG-------------------U-U U-A------------------CCUCGAUAAAUCAUCUAAGUUUCUG-CCCUAUCA-GCUC UCGAUGGUAGUGUAUUGGACUA-CCAUGGCAGUCACGGGUAACGGAGAAUUAGGGUUC-G AUUCCGGAGAAGGAGCCUGAGAAACGGCUACUACAACUACGGUUCGGCAGCAGGGAAGAA AAUUGGCCAAUCCUA--AU----UCAGGGAGCCAGUGACAAGAAAUAGCAAGCUGGG-AA AC--UU-AC--GUUU-CUACGGCAUUGAAAUGAGAACAGUG--------------UAA-A U-C-----------------UCUUAGCGAGGAACAAUUGGAGGGCAA-GUCAUGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGUUGCAGUUAAAAAGCUC GUAGUUGAACUUCUGUUCAG-GUUC-A-UUUCG-A------------------------- -UUCG---------------------------------------UCGUGUGAAACUGGAC AUA---------------------CGUUUGCAA--------------------------- ------------------------------------------------------------ ----------------------ACUAA-AAU-CGGCC-UUCACU-GGUU-CGACU--U-- -----AG-GG-------AGUAAA-CA-U-UUUACUGUGAAAAAAUUAGAGUGUUCCAGGC AGGU------U--UUA-------G-C--C--CGAAU-ACA-UUAGCAUGGAAUAAUGGAA UAGGA----------CU-A--AGUCCAU-----U-UU-AUU-GGUU-------CUUG-GA --U-UUG-GUA------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAU-AGGGACAGUU G-GGGGCAUUAGUA-UUUAAUAGUCAGAGGUGAAAUUCUUGGAUUUAUUAAGGACUAACU AAUGCGAAAGCAUUUGCCAAAGAUGUUUUCAUUAAUCAAGAACGAAAGUUAGGGGAUCAA AGACGAUCAGAUACCGUC-GUAGUCUUAACUAUAAACUAUAC-CGACUCGGGAUCGGCUG GAA--------------------------------------------------------- ---UAAAU---------------------------------------------------- --------------------GUCCAGUCGGCACCGUAUGAGAAAUC-A--AAGUC----- ---UUUGGGUU-CUGGGGGAAGUAUGGUACGCAAGUC-UGAAACUUAAAGGAAUUGACGG AACAGCA-CACCA-GAAGUGGAACCUGCGGCUUAAUUUGACUCAACACGGGGAA-ACUC- A-CGA-GCG-CA-AGACAGAG-AAG-GGAUUGA-CAGAUUGAGAGC-UCUU-U-CUUGA- --------------------UUCU-UUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GUGAUUUGUCUGGUUAAUUCCGUUAACGAACGAGACCUU-AACCUGCUAACUAGUCU GCUUGU------------------------------------------------------ ------------------------------------------------------------ ---------------AA-AU--A------------------------------------- ------------------------------------------------------------ -------------------------------------------------AC-A------- --G-GU---U---GUACUUCUUAGAGGGACU-AUUGUG----CAA-UAAGC-CA-AUGGA AGUUUAAGGCAAUAACAGGUCUGUGAUGCCCCUAGACGUGCUCGGCCGCACGCGCGUUAC AAUG-ACUGGCGCAAAAAGU-------------------------------AUU------ ----------------------UCCUGUCCUGGGAAGGUACGGGUAA-UCUU-AUUAAUA CCA-GUCGUGUUAGGGAUAGUUCUUUGGAAUUGUGGAUCUUG-AACGAGGAAUUUCUAGU AAGUGCAA-GUCAUC-AGCUUGCGUUGAUUAUGUCCCUGCCGUUUGUACACACCGCCCGU CGCUUGUAGUAAC-GAAUGGUC-UGGUGAACCUUCU-GGACU-GCGAC-A---------- ----G-CA-A--------------U-G-U-U-GCGGAAAA----------AUAAGUAAAC CCUACCAUUUGGAACAACAAGAAGUCGUAACAAGGUAUCUGUAGGUGAACCUGCAGAUGG AUCAUUA--------------- >Thalassiosira_pseudonana ----------------UACCUGGUUGAUUCUG-CCAGUAGUCAU-ACGCUCGUCUC-A-A AGAUUAAGCCAUGCAUGUCUAAGUAUAACCA---------------------UU---A-U -----------------------ACA-GG--AA-AAC-U-GCG-AACGGCUCAUUAUAUC AGUUAUUGU-UUCUUUGAUA-GUCCCUUACU----------ACUUGG--AUACCUG--U- A-GUAAUUCUAGAGCUAAUACAUGCAUCA--AUACCC---G---------------A-CU ---G----------------UUC-G-----------------C----GG----------A A---GGGUA---GUAUUUAUUAGGUA---UAGAC-C-AAC--------C-GUC------- ------------------UUC-G------------------------G-ACGUG-CUU-U --GGU-GA-UUCAUAAUAACUUAU-CG-GA--UCGCAUG-GC---------------U-C C-A-U--------------GCCGGCGAUGGAUCAUUCAAGUUUCUG-CCCUAUCA-GCUU UGGAUGGUAGUGUAUUGGACUA-CCAUGGCUUUAACGGGUAACGAAUUGUUAGGGCAA-G AUUUCGGAGAGGGAGCCUGAGAGACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGUA AAUUACCCAAUACUG--AA----ACAGUGAGGUAGUGACAAUAAAUAACAAUGCCGG-GC CU--UU-AC--AGGU-CU-GGCAAUUGGAAUGAGAACAAUU--------------UAA-A U-C-----------------CCUUAUCGAGUAUCAAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGUUGCAGUUAAAAAGCUC GUAGUUGGAUUUCUGGCAGG-AGCG-A-C-CGG-UCUCACAC------------------ -UCA-------------------------G-U-G-CG-A----GAACUCGUGUUGUCUCU GGCCAUCC----------------UUGGGGAUA--------------------------- ------------------------------------------------------------ ----------------------UCC-U-GUU-UGGCA-UUAAGU-UGUC--GGGC--A-- -----GG-GG-------AUACCC-AUCG-UUUACUGUGAAAAAAUUAGAGUGUUUAAAGC AGGC------U--UAU-------G-C--CGUUGAAU-AUA-UUAGCAUGGAAUAAUAAGA UAGGA----------CC-C--UGGUACU--A-UU-UU-GUU-GGUU------UGCGC-AC --C-GAG-GUA------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAA-AGAGACAGGC G-GGGCUAUUCGUA-UUGCAUUGUCAGAGGUGAAAUUCUUGGAUUUCUGCAAGACGAACU ACUGCGAAAGCAUUUAGCAAGGAUGUUUUCAUUAAUCAAGAACGAAAGUUAGGGGAUCGA AGAUGAUUAGAUACCAUC-GUAGUCUUAACCAUAAACUAUGC-CGACUCGGGAUUGGCGG UUGUU------------------------------------------------------- ---UU-UU---------------------------------------------------- -------------------GACUCCGCCAGCACCGUAUGAGAAAUC-A--AAGUC----- ---UUUGGGUU-CCGGGGGGAGUAUGG-UCGCAAGGC-UGAAACUUAAAGAAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGAAA-ACUU- A-CCA-GGU-CC-AGACAUAG-UGA-GGAUUGA-CAGAUUGAGAGU-UCUU-U-CUUGA- --------------------UUCU-AUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GUGAUUUGUCUGGUUAAUUCCGUUAACGAACGAGACCGC-CGCCUGCUAAAUAGUUC UGCGAAUGG--------------------------------------------------- ------------------------------------------------------------ ----------------U-UU--U------------------------------------- ------------------------------------------------------------ -------------------------------------------UC--A-UU-G------- --G-CAA--G----AGCUUCUUAGAGGGACG-UUCA-U---UCUA-CAAGA-UG-AAGGA AGAUGGCGGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUCCUGGGCCGCACGCGCGCUAC ACUG-AUGCACUCAACGAGC-------------------------------AUAUA---- ----------------------A-CCUUGGCCGAGAGGCCUGGGUAA-UCUU-GUUAACA UGC-AUCGUGAUAGGGAUAGAUUAUUGCAAUUAUUAAUCUUG-AACGAGGAAUUCCUAGU AAUCGCAG-AUCAUC-AAUCUGCAAUGAUUACGUCCCUGCCCUUUGUACACACCGCCCGU CGCACCUACCGAUUGGAUGGUC-CGGUGAGGAGUCG-AGAUU-GUGGC-CU-GG-UUCC- U---U-UA-U-----U-GGGAUUUG-G-C-U-ACGAGAAC----------UUCUCCAAAC CUUAUCAUCUAGAGGAAGGUGAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUA--------------- >Trypanosoma_brucei ----------------GAUCUGGUUGAUUCUG-CCAGUAGUCAU-AUGCUUGUUUC-A-A GGACUUAGCCAUGCAUGCCUCAGAAUCACUG---------------------CA---U-U -----------------------GCA--G--GA-AUC-U-GCG-CAUGGCUCAUUACAUC AGACGUAAU-CUGCCGCCAA-AAUUUUGCGGUCUCCGCAUUACU-GG--AUAACUU--G- G-CGAAACGCCAAGCUAAUACAUGAACCAAUCGGACGCU-CUCUUUUUCUAUGUCG-CGG CUUGU---------GU----UUA-C---G-----------CAC-UUGUCGUGGCGAUGG- --GACGUCC---AGCGAAUGAAUGAAAUUAGAAC-C-AACGCCUCCACCCGGG------- --------------GGCAGUA-ACAC---------------------U-CAG---ACG-U --GUU-GACUCAAUUCAUUCCGUG-CG-AA--AGCCGAG-C----------------CUU G-U-U--------------GCUCGGCGUCUACUGA-CGAACAACUG-CCCUAUCA-GCCA GUGAUGGCCGUGUAGUGGACUG-CCAUGGCGUUGACGGGAG-CGGGGGAUUAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAAUAGCUACCACUUCUACGG-AGGGCAGCAGGCGCGCA AAUUGCCCAAUGUCG-AAAAAAUACGAUGAGGCAGCGAAAAGAAAUAGAGCCGACCG-UG CC--CU-AG--UGCA-UG-GUUGUUUUCAAUGGGGGAUACU--------------CAA-A CCCA------------U-C-CAAUAUCGAGUAACAAUUGGAGGACAA-GUC-UGGUGCCA GCACCCGCGGUAAUUCCAGCUCCAAAAGCGUAUAUUAAUGCUGUUGCUGUUAAAGGGUUC GUAGUUGAACUGUGGGCCACGUAGUUU--UGUGCC-GUGCCAGUCCCGUCC--------- ACCUC----------------GGA-CGUGUUUUG-ACCC-----ACGCCCUCGUGGCCCG UGAACACACUCAGAUACAAGAA--ACACGGG--AGCGG---------------------- -------------------------------------------------UUCC------- ----------UCCUC--ACU---UU-C-ACG-CAUGU---CAU--GCAU--GCGA--G-- -----GGG---GCG----UCCGU-GAAU-UUUACUGUGACCAAAAAAGUGCGACCAAAGC AGUC------U--GCC-------G-A--C-UUGAAU-UAC-AAAGCAUGGGAUAACGAAG CAUCAGCCCUGGGG-CC-ACCGUUUCGG--C-UU-UU-GUU-GGUU-----UUAGAA-GU CCU-UGG-G-AGAUUAUGGGGCCGCGUGCCUUGGGUC-----GG-UGUUUCGUGUCUCAU UUUUGUGGCGCGCA----CAUUCGGCU-CUUCGUGAUGUUU------------------- UUUUAC----------AUUCAUUGCGACGCGCGGCUUCCAGGAAUGAAG-GAGGGUAGUU CGGGGGAGAACGUA-CUGGUGCGUCAGAGGUGAAAUUCUUAGACCGCACCAAGACGAACU ACAGCGAAGGCAUUCUUCAAGGAUACCUUCCUCAAUCAAGAACCAAAGUGUGGGGAUCAA AGAUGAUUAGAGACCAUU-GUAGUCCACACUGCAAACCAUGA-CACCCAUGAAUUGGGGA ACAUCAUUGGGUGCCCGUGUGGCGGCCUUUUGUGCCGACCCUCGGCCCCAAUUUAUUUAU CAAUUUACGUGCCUAUUCUAUCACCCCCGGUUCCCUCUUUUGAGGUUCUUCCGGGGUUUU UUACGGGAAUAUCCUCAGCACGUUUCUUACUUCUUCACGCGAAAGCUUG-GAGGU----- ---UACAGUCU-CAGGGGGGAGUACGU-UCGCAAGAG-UGAAACUUAAAGAAAUUGACGG AAUGGCACCACAA-GACGUGGAGCGUGCGGUUUAAUUUGACUCAACACGGGGAA-CUUU- A-CCA-GAU-CC-GGACAGGG-UGA-GGAUUGA-CAGAUGGAGUGU-UCUU-U-CUCGA- --------------------UCCC-CUGA-AUGGUGGUGCAUGGCCGCUUUUGGUCGGUG GA-GUGAUUUGUUUGGUUGAUUCCGUCAACGGACGAGAUCCA-AGC-UGCCCAGUAGGUG CCGGGAUUGUCCACACAGGACAGCAGUCCCU-CCGGCGGGGAU----------------- ------------------------------------------------------------ ----------------U-UU---------------------------------------- ------------------------------------------------------------ --------------U--------UC--C-CCAACGGUG-GU--CGUCA-UC-CUUCUUUU UACAG---GC----CCCUUCUCUGCGGGAUU-CCUU-G--CUUUU-CGCGC-AA-GGUGA GAUUUUGGGCAACAGCAGGUCUGUGAUGCUCCUCAAUGUUCUGGGCGACACGCGCACUAC AAUG-UCAGUGAGAACAAGA---GUCCGAGCGGCA--------------CUUCACAA--- ----------UGUCGCUCC---C-GCUUGAUCAAAAGAGCGGGGAAACCACG-GAAUCAC GUA-GACCCACUUGGGACCGAGUAUUGCAAUUAUUGGUCGCGCAACGAGGAAUGUCUCGU AGGCGCAG-CUCAUC-AAACUGUGCCGAUUACGUCCCUGCCAUUUGUACACACCGCCCGU CGUUGUUUCCGAU-GAUGGUGC-AAUACAGGUGAUC-GGACC-GUCGC-UC-G------- ----U-CU--------------CGG-G-C-G-ACCGAAAG----------UUCACCGAUA UUGCUUCAAUAGAGGAAGCAAAAGUCGUAACAAGGUAGCUGUAGGUGAACCUGCAGCUGG AUCAUUU--------------- >Yarrowia_lipolytica ----------------UAUCUGGUUGAUCCUG-CCAGU---CAU-AUGCUUGUCUC-A-A AGACUAAGCCAUGCAUGUCUAAGUAUAAACAA--------------------UU---A-U -----------------------ACA-GU--GA-AAC-U-GCG-AACGGCUCAUUAAAUC AGUUAUCGU-UUAUUUGAUA-GUUUUCU-------------ACAUGG--AUAACCG--U- G-AUAACUUCAGAACUAAUACAUGA------CAGC-----------------------CU ---------------------UC-U----------------------GG----------- C---G--------UAUAUAUUAGAUA--CAA-AC-C-AA--------------------- --------------------C----------------------------AG-U---AU-- --GGU-GA-UUCAUAAUAUCUUGU-CG-AA--CCG-AU-------------------C-U U-----------------------CGGUGUAUCAUUCAAAUUUCUG-CCCUAUCA-ACUG UCGAUGGUAGGAUCGUGGCCUA-CCAUGGUAACAACGGGUAACGGGGAAUCAGGGUUC-U AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCAAUCCUG--AC----ACAGGGAGGUAGUGACAAUAUAUAACGAUCCGGG-GC UC--UU--U--GAGU-UU-CGGAAUUGGAAUGAGUACAAUU--------------UAA-A C-A-----------------CCUUAACGAGGAACAAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAUGUUGUUGCAGUUAAAAAGCUC GUAGUUGAAAUUGGGCGGGC-U-------------------------------------- --AU-----------------------------U--A-G----UUUAGGCCGC----UUC ----------------------------AGGAA--------------------------- ------------------------------------------------------------ --------------------GAAC--U-------------UCU--------------U-- ------------------CCA-G-------UUACUUUGAAAAAAUUAGAGUGUUCAACGC AGGU------U---UC-------G-C--C--UGAAU-AUA-UUAGCAUGGAAUAACAUAA CACGA----------CG-A--GGGUCC---A-UU-UU-GUU-GGCU-----UGCAA--AC --C-CAC-GUA------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAU-AGGGACAGUC G-GGGGCGUCAGUA-UUGUGUUGUCAGAGGUGAAAUUCUUGGAUUUACACAAGACUAACU ACUGCGAAGGCAUUCGCCAAGGAUGUAUUCAUUAAUCAAGAACGAAAGUUAGGGGAUCAA AGAUGAUCAGAUACCGUC-GUAGUCUUAACCGUAAACUAUGC-CGACUGAGAAUGGGUAC CG---------------------------------------------------------- ---CUUAU---------------------------------------------------- --------------------ACGGUAUCCGCGCUCUACGAGAAAUC-A--AAGUG----- ---AUCAGGUU-CUGGGGGGAGUAUGG-UCGCAAGGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGGAC-UGCGGCUUAAUUUGACUCAACACGGGGAA-ACUC- A-CCA-GGU-CC-AGACACAA-UAA-GGAUUGA-CAGAUUGAUAGC-UCUU-U-CUUGA- --------------------UUUU-GUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GUGAUUUGUCUGCUUAAUUGCGAUAACGAACGAGACCUU-GACCUACUAAAUAGCUC UACNNC------------------------------------------------------ ------------------------------------------------------------ ----------------G-AU--U------------------------------------- ------------------------------------------------------------ -----------------------------------------------G-CA-G------- --G-U--A-GCU--AGCUUCUUAGAGGGACU-AUCU-A----UUA-CAAGU-AG-AUGGA AGUUCGAGGCAAUAACAGGUCUGUGAUGCCCUUAGACGUUCUGGGCCGCACGCGCGCUAC ACUG-ACGGAGCCAGCGAGU-------------------------------CG------- ----------------------A-CCAAGCCCGAGAGGGCUAGGUAA-UCUU-GUGAAAC UCC-GUCGUGCUGGGGAUAGAGCAUUGCAAUUAUUGCUCUUC-AACGAGGAAUUCCUAGU AAGCGCAA-GUCAUC-AGCUUGCGUUGAUUACGUCCCUGCCCUUUGUACACACCGCCCGU CGCUACUACCGAUUGAAUGGUU-UAGUGAGACCUUG-GGAG--GGC-G-AG-AU-GAGG- GGG-G-CA-A----CC-CC-UUUUG-A-A-C-AUCCAAAC----------UUGGUCAAAC UUGAUUAUUUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUA--------------- >Xenopus_laevis ----------------UACCUGGUUGAUCCUG-CCAGUAG-CAU-AUGCUUGUCUC-A-A AGAUUAAGCCAUGCACGUGUAAGUACGCACGGC-------------------CG---G-U -----------------------ACA-GU--GA-AAC-U-GCG-AAUGGCUCAUUAAAUC AGUUAUGGU-UCCUUUGAUC-GCUCCAUCUGUU--------ACUUGG--AUAACUG--U- G-GUAAUUCUAGAGCUAAUACAUGCCGACG-AGCGCU---G---------------A-CC ---CC-----------------------------------CAG----GG----------A ----UGCGU---GCAUUUAUCAGACC---AAAAC-C-AAU--------C-CGGG------ ------------GC----CCC-C---GC--------------GC--CC-CGGCC-GCU-U U-GGU-GA-CUCUAGAUAACCUCGGGCCGA--UCGCACG-UC---------------C-C C-G-U--------------GACGGCGACGAUACAUUCGGAUGUCUG-CCCUAUCA-ACUU UCGAUGGUACUUUCUGCGCCUA-CCAUGGUGACCACGGGUAACGGGGAAUCAGGGUUC-G AUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGG-AAGGCAGCAGGCGCGCA AAUUACCCACUCCCG--AC----GCGGGGAGGUAGUGACGAAAAAUAACAAUACAGG-AC UC--UU-UC--GAGGCCC-UGUAAUUGGAAUGAGUACACUU--------------UAA-A U-C-----------------CUUUAACGAGGAUCUAUUGGAGGGCAA-GUC-UGGUGCCA GCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGCUGCAGUUAAAAAGCUC GUAGUUGGAUCUUGGGAUCG-AGCU-G-G-CGG-UCCGCC-------------------- -GCGA----------------------------G-GC-GA---GCUACCGCCUGUCCCAG CCCCUGCC----------------UCUCGGCG---------------------------- ------------------------------------------------------------ ---------------------CCUC-CCCGA-UGCUC-UUGACU-GAGU--GUCC-CG-- -----GG-GG--------CCCGA-AGCG-UUUACUUUGAAAAAAUUAGAGUGUUCCAAGC AGGC-----CG--CGUC------G-C--C--UGGAU-ACU-UCAGCUAGGAAUAAUGGAA UAGGA----------CU-C--CGGUUCU--A-UU-UU-GUU-GGUU-----UUCGGA-AC --U-GGG-GCC------------------------------------------------- ------------------------------------------------------------ ----------------------------------------AUGAUUAAG-AGGGACGGCC G-GGGGCAUUCGUA-UUGUGCCGCUAGAGGUGAAAUUCUUGGACCGGCGCAAGACGAACC AAAGCGAAAGCAUUUGCCAAGAAUGUUUUCAUUAAUCAAGAACGAAAGUCGGAGGUUCGA AGACGAUCAGAUACCGUC-GUAGUUCCGACCAUAAACGAUGC-CGACUAGCGAUCCGGCG GCGUU------------------------------------------------------- --AUUCCCAU-------------------------------------------------- -------------------GACCCGCCGAGCAGCUUCCGGGAAACC-A--AAGUC----- ---UUUGGGUU-CCGGGGGGAGUAUGG-UUGCAAAGC-UGAAACUUAAAGGAAUUGACGG AAGGGCACCACCA-GGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGAAA-CCUC- A-CCC-GGC-CC-GGACACGG-AAA-GGAUUGA-CAGAUUGAUAGC-UCUU-U-CUCGA- --------------------UUCU-GUGG-GUGGUGGUGCAUGGCCGUUCUUAGUUGGUG GA-GCGAUUUGUCUGGUUAAUUCCGAUAACGAACGAGACUCC-UCCAUGCUAACUAGUUA CGCGACC----------------------------------------------------- ------------------------------------------------------------ ---------------CC-CG--GC------------------------------------ ------------------------------------------------------------ -----------------------------------------------G-GU-C-----G- --G-C--G-UCC--AACUUCUUAGAGGGACA-AGUG-G----CGU-UCAGC-CA-CACGA -G-AUCGAGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUCCGGGGCUGCACGCGCGCUAC ACUG-AACGGAUCAGCGUGU-------------------------------GUC------ ---------------------UACCCUGCGCCGACAGGUGCGGGUAACCCGC--UGAACC CCG-UUCGUGAUAGGGAUCGGGGAUUGCAAUUAUUUCCCAUG-AACGAGGAAUUCCCAGU AAGUGCGG-GUCAUA-AGCUCGCGUUGAUUAAGUCCCUGCCCUUUGUACACACCGCCCGU CGCUACUACCGAUUGGAUGGUU-UAGUGAGGUCCUC-GGAUC-GGCCC-CG-CC-GGGG- UCG-G-C-CA---CGG-CCCUGGCG-GAGCG-CCGAGAAG----------ACGAUCAAAC UUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGG AUCAUUA---------------