$PROBLEM run1.mod

$INPUT ID DOSE NTOT DV DROP DROP DROP

$DATA paresthesia_DR.csv IGNORE=@

$PRED
  E0 = THETA(1) + ETA(1)
  EMAX = THETA(2)
  ED50 = THETA(3)

  LGT = E0 + EMAX*DOSE/(ED50 + DOSE)

  PR1 = 1/(1+EXP(-LGT))
  PR0 = 1-PR1

  Y = -2*(DV*LOG(PR1) + (NTOT-DV)*LOG(PR0))

$THETA 
(-3 )     ;E0 (~P1=.05)
(3)       ;EMAX (~P1=.5)
(0, 20 )  ;ED50

$OMEGA 
1

$ESTIMATION MAXEVAL=9999 METHOD=1 LAPLACE -2LL FILE=run1.ext
$COV PRINT=E