#PNAME,PMEAN,IGNORE,PCOV,PTYPE,PBLOCK,PTRANSF,PLOW,PHIGH,OCCNAM,NOCC,OCCMEAN,OCCVAR,VARINI,VARNIT,VARBURN,VARIT,PBOUNDL,PBOUNDH,T12K,SUBR,COVS,VTYPE #Parameter name,Mean of parameter,.,Variance of parameter,Parameter Type,Parameter block in var-cov matrix,Parameter Transformation,Lower boundary of logistically transformed variable,Upper boundary of logistically transformed variable,Variable name defining between occasion variability,Number of occasions,Mean of BOV deviate,variance of bov parameter,Initial variance,Variance after nn interations,No of steps with variance untouched,Number of interactions,Lower boundary for individual estimates,Upper boundary for individual estimates,Transform t1/2 or MTT into rate constant,Subroutines,Source file for covariate,Variable type #,.,.,.,P: Theta with Omega,0: no variance,L: Lognormal,.,.,.,.,.,.,.,.,.,.,.,.,T12: half-life,D=DIFFEQ,, #,.,,.,PC: population mean affected by covariate,1: block 1,N: normal,.,.,.,.,.,.,.,.,.,.,.,.,MTT: inverse,A=AMAT,, #,.,,.,V: residual variability,2: block 2,O: Logistic,.,.,.,.,.,.,.,.,.,.,.,.,T12m: min->h,O=OUTPUT,, #,.,,.,C: (fixed) covariate effect,3: block 3,.,.,.,.,.,.,.,.,.,.,.,.,.,MTTm: min->h,Y=SYMBOL,, #,.,,.,N: Fixed,etc.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,V=VARMOD,, #,.,,.,M: Mixture probability parameter (not supported),.,.,.,.,.,.,.,.,.,.,.,.,.,.,NOT supported,S=SEC_PARAMS,, #,.,,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,M=POPMOD,, #,.,,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,T=POPTRN,, #,.,,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,I=POPITRN,, #,.,,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,C=POPCON,, #,.,,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,P=VARMODPD,, #,.,,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,F=POPFINAL,, #,.,,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,. #,.,,.,.,Use _ to separate two double digit numbers like _11_12_,This column is ignored for PC type parameters,The default value of 0 does not need to be defined,The default value of 1 does not need to be defined,.,.,.,.,.,.,.,.,This sets the PL(.) vector,This sets the PH(.) vector,This assumes that the code goes into diff. eq.,All parameters are by default put into subroutine symbol,.,. #,.,,.,.,Leave column blank,,,,,,,,,,,,,,,,, #,.,,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,. LG_INOC,6,,0.5,P,1,N,,,.,.,.,.,1,,30,,,,,,, LG_POPmax,9.5,,0.5,P,2,N,,,,,,,1,,30,,,,,,, MDT,300,,1,P,3,L,,,,,,,1,,30,,,,,,, MGT,60,,1,P,4,L,,,,,,,1,,30,,,,,,, KC50S,1,,1,P,5,L,,,,,,,1,,30,,,,,,, Kmax,4,,1,P,6,L,,,,,,,1,,30,,,,,,, LG_MUTF,-5,,1,P,7,N,,,,,,,1,,30,,,,,,, SDin,1,,1,V,,,,,,,,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,, COVARIATES,,,,,,,,,,,,,,,,,,,,,, CDRUGcut,,,,,,,,,,,,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,, RUN_SETTINGS,,,,,,,,,,,,,,,,,,,,,, NFILE,Simulation_5_estimation_6,,,,,,,,,,,,,,,,,,,,, VERS,1,,,,,,,,,,,,,,,,,,,,, mdelete _*,,,,,,,,,,,,,,,,,,,,,, DATAFILE,../Data/data_set.csv,,,,,,,,,,,,,,,,,,,,, COVFILE,../Data/Covariates.csv,,,,,,,,,,,,,,,,,,,,, BEOFILE,beo.txt,,,,,,,,,,,,,,,,,,,,, NPOPITER,200,,,,,,,,,,,,,,,,,,,,, GEFFICIENCY,0.6,,,,,,,,,,,,,,,,,,,,, PMETHOD,4,,,,,,,,,,,,,,,,,,,,, NPOP,100,,,,,,,,,,,,,,,,,,,,, NPOPC,1000,,,,,,,,,,,,,,,,,,,,, NDELPAR,15,,,,,,,,,,,,,,,,,,,,, ATOL,5,,,,,,,,,,,,,,,,,,,,, RTOL,5,,,,,,,,,,,,,,,,,,,,, WRES_TYPE,2000,,,,,,,,,,,,,,,,,,,,, beosetup,,,,,,,,,,,,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,, RUN_COMMANDS,,,,,,,,,,,,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,, piteraten,,,,,,,,,,,,,,,,,,,,,, ?finish.txt,,,,,,,,,,,,,,,,,,,,,, stop,,,,,,,,,,,,,,,,,,,,,,