% % -------------------------------- % % EXPERIMENTALLY-BASED CALIBRATION % % -------------------------------- % % Ranges for normalized currents: % % -------------------------------- % [min max] scaling for IKr 0.5826 1.4174 % [min max] scaling for IKs 0.2197 1.7803 % [min max] scaling for Ito1 0.6042 1.3958 % [min max] scaling for ICaL 0.5164 1.4836 % % Ranges for APD and APD change with respect to control: % % -------------------------------- % [min(APD) max(APD) min(Delta_APD) max(Delta_APD)] for Control 175.0000 279.1743 0 0 % [min(APD) max(APD) min(Delta_APD) max(Delta_APD)] for IKr block 192.1108 401.3508 -24.0552 193.3240 % [min(APD) max(APD) min(Delta_APD) max(Delta_APD)] for IKs block 170.0722 284.4007 -27.6303 43.0023 % [min(APD) max(APD) min(Delta_APD) max(Delta_APD)] for IKs & Ito1 block 120.1216 325.4230 -109.5096 110.8022 % [min(APD) max(APD) min(Delta_APD) max(Delta_APD)] for ICaL block 46.5106 179.7722 -179.3852 -38.5725