Addiction of Hypertransformable Pneumococcal Isolates to Natural Transformation for In Vivo Fitness and Virulence

Supplemental material

• Supplemental file 1 -

  Fig. S1. Growth kinetics of the six low-transformability pneumococcal isolates and isogenic competence-deficient mutants. Fig. S2. Growth kinetics of the six intermediate-transformability pneumococcal isolates and isogenic competence-deficient mutants. Fig. S3. Growth kinetics of the six high-transformability pneumococcal isolates and isogenic competence-deficient mutants. Table S2. Bacterial strains used in this study. Table S3. Plasmids used in this study. Table S4. Primers used in this study.

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• Supplemental file 2 -

  Table S1. Relative transformation frequencies of the invasive isolates of S. pneumoniae.

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