Arteriosclerosis, Thrombosis, and Vascular Biology ATV Platelets: context dependent vascular protectors or mediators of disease EARLY CAREER ARTICLE HIGHLIGHTS: PLATELETS ATVB/2015/305898 ATVB/2015/305898 10.1161/ATVBAHA.115.305898 35 07/01/15 7 Meyer Trudie Mackman, Nigel University of North Carolina Dr. Gabrielle Fredman gf2269@cumc.columbia.edu Dr. Columbia University Medical Center 630 W. 168th St. PH 9-406 New York New York 10032 UNITED STATES 2123055669 2123055954 197413 Randal J Westrick Oakland University rjwestrick@oakland.edu 6040 Gabrielle Fredman Columbia University Medical Center gf2269@cumc.columbia.edu 197413 05/16/2015 05/16/2015 05/31/2015 06/01/2015 06/02/2015 06/25/2015 Recent Highlights Thrombosis Platelets are unique anucleate blood cells produced by megakaryocytes that, in addition to being the primary effectors of hemostasis, are rapid responders to injury and infection. Therefore, platelets have a diverse functional repertoire in their ability to regulate inflammation, host defense and tissue repair. This review highlights some of the recent ATVB publications regarding the role of platelets in inflammatory vascular disease, the mechanisms of platelet thrombotic action, and insights into new anti-platelet therapies. 0 0 0 0 0 no yes ATVB_ATVB-2015-305898.xml ATVB_ATVB-2015-305898_file1.docx ATVB_ATVB-2015-305898_merge.pdf ATVB_ATVB-2015-305898_Westrick_6040_disclosure.pdf ATVB_ATVB-2015-305898_Westrick_6040_copyright.pdf ATVB_ATVB-2015-305898_Fredman_197413_disclosure.pdf ATVB_ATVB-2015-305898_Fredman_197413_copyright.pdf highlight article topic: Platelets All pages waived, online only. Funding: Howard Hughes Medical Institute (HHMI): No National Institutes of Health (NIH): Yes Not applicable for this manuscript: No Other: No Wellcome Trust: No Subject Codes: [135] Risk factors [92] Platelets tmeyer