"Supplementary file 7 – Posterior probability assigned to eggNOG/COG identifiers after sensitivity adjustment with ?=6.65. The table lists the eggNOG/COG identifier, its eggNOG 4.0 annotation and functional category, the number of mapped promoters before and after sensitivity adjustment and the posterior probability for all eggNOG/COGs with at least 5 promoters mapping to them after sensitivity adjustment.",,,,,
,,,,,
eggNOG/COG ID,eggNOG v4.0 annotation,eggNOG v4.0 functional category,# of genes mapped,# of genes mapped (sensitivity adjusted),Posterior probability (sensitivity adjusted)
COG1937,Transcriptional repressor,S,530,332,1
COG2217,p-type ATPase,P,1580,422,1
NOG218972,Heavy-metal-associated domain,S,16,7,1
NOG72602,Predicted membrane protein (DUF2318),S,16,5,1
NOG109008,[NoAnn],S,18,5,1
COG2836,Membrane,S,36,8,0.999999999
COG4633,heavy metal transport detoxification protein,S,28,6,0.999999999
NOG81268,Heavy-metal-associated domain,S,34,6,0.99999987
NOG54266,integral membrane protein,S,40,5,0.327084864
COG3458,acetyl xylan esterase,Q,19,6,0.091277406
NOG101752,heavy metal transport detoxification protein,P,18,7,0.016645819
NOG11947,dehydrogenase,R,38,8,0.000922923
NOG90810,[NoAnn],S,43,5,0.000746412
COG0588,Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity),G,59,14,0.000439352
NOG10610,(ABC) transporter,P,71,13,0.000113739
COG3323,"ngg1p interacting factor 3 protein, nif3",S,33,7,8.17996E-05
NOG215589,"acetyltransferase, (GNAT) family",R,22,5,7.57513E-05
NOG12383,surface antigen BspA-like,S,32,6,5.33478E-06
NOG105980,prophage LambdaBa04 DNA packaging protein,L,22,5,3.88361E-06
NOG41988,Prophage Lp2 protein 4,R,13,5,3.70519E-06
NOG86323,flagellar protein FlaG protein,N,33,16,2.95113E-06
NOG01004,chromosome segregation atpase,S,40,5,2.74812E-06
NOG49342,ABC transporter (permease),R,69,7,2.20307E-06
NOG33132,S-layer homology domain,S,17,5,1.27505E-06
NOG03231,[NoAnn],S,48,5,1.09496E-06
COG0555,(ABC) transporter,P,38,5,8.78819E-07
NOG22253,[NoAnn],S,76,9,7.03668E-07
COG1963,Acid phosphatase vanadium-dependent haloperoxidase related,S,133,11,6.8079E-07
COG0644,geranylgeranyl reductase,C,42,5,5.91925E-07
NOG114595,[NoAnn],S,18,5,5.87599E-07
NOG39245,[NoAnn],S,35,5,5.46662E-07
NOG48559,Phage Portal Protein,R,64,10,3.61755E-07
COG0746,Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity),H,41,6,3.28605E-07
NOG53858,[NoAnn],S,29,6,3.14588E-07
COG1379,Uvrd rep helicase,S,102,7,2.87808E-07
COG1137,(ABC) transporter,R,26,5,2.3738E-07
COG1456,Acetyl-CoA decarbonylase synthase complex subunit gamma,C,41,5,2.13057E-07
NOG04897,[NoAnn],S,21,5,1.94711E-07
NOG03478,Methyl-accepting chemotaxis,S,16,6,1.8246E-07
NOG215645,[NoAnn],S,11,5,1.74873E-07
COG4679,Phage-related protein,S,84,6,1.37712E-07
NOG21801,Transmembrane protein 229b,S,38,5,1.03745E-07
NOG17128,succinylglutamate desuccinylase aspartoacylase,S,29,6,1.02723E-07
NOG05291,[NoAnn],S,41,6,8.60363E-08
NOG04604,heparinase II III family protein,S,26,5,7.63375E-08
NOG05036,binding-protein-dependent transport systems inner membrane Component,P,60,6,6.63391E-08
NOG63939,Polyketide cyclase / dehydrase and lipid transport,S,47,5,5.33405E-08
NOG08013,NERD domain protein,S,89,6,3.74414E-08
NOG101316,50s ribosomal protein l34,J,31,5,3.33647E-08
NOG91286,metallophosphoesterase,R,22,5,2.90791E-08
NOG225964,Pfam:PhdYeFM,S,29,5,2.61508E-08
COG1620,L-Lactate permease,C,63,6,2.50034E-08
COG2235,Arginine dihydrolase,E,47,6,1.85446E-08
COG0362,"Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)",G,17,6,1.73292E-08
COG1881,phospholipid-binding protein,S,17,5,1.7201E-08
COG2169,Transcriptional regulator,F,28,6,1.69164E-08
NOG218157,HTH_XRE,K,30,5,1.6165E-08
NOG58161,[NoAnn],S,19,5,1.58251E-08
COG3500,Late control D family protein,R,69,6,1.35495E-08
NOG214204,Acetyltransferase (GNAT) family,R,13,5,1.35163E-08
NOG57049,[NoAnn],S,55,7,1.33914E-08
NOG71845,[NoAnn],S,21,5,1.33007E-08
COG3568,Endonuclease Exonuclease Phosphatase,R,65,5,1.29844E-08
NOG07601,abc transporter permease protein,V,23,6,1.27028E-08
NOG14321,Hydrolase,R,35,6,1.24878E-08
NOG220566,[NoAnn],S,25,5,1.18229E-08
NOG67614,Transcriptional regulator,K,20,8,1.13728E-08
NOG73817,"Catalyzes the acylation of glycosyl-4,4'- diaponeurosporenoate, i.e. the esterification of glucose at the C6'' position with the carboxyl group of the C(15) fatty acid 12- methyltetradecanoic acid, to yield staphyloxanthin. This is the last step in the biosynthesis of this orange pigment, present in most staphylococci strains (By similarity)",S,30,5,1.06129E-08
NOG01890,Nucleotidyl transferase of unknown function (DUF1814),S,29,5,9.99026E-09
NOG116971,[NoAnn],S,23,5,9.50595E-09
NOG84980,#NAME?,R,37,5,9.34293E-09
NOG212281,transposase,L,53,5,9.17466E-09
NOG102422,[NoAnn],S,52,5,9.01075E-09
NOG79399,Abc-2 type transporter,S,16,5,8.80545E-09
NOG03519,chromosome segregation ATPase-like protein,S,26,5,8.33218E-09
NOG07563,Protein of unknown function (DUF2398),S,23,5,8.332E-09
NOG33000,Uroporphyrinogen decarboxylase,H,31,5,8.19239E-09
COG4208,sulfate abc transporter,P,30,5,7.87205E-09
NOG52260,cell wall anchor domain protein,M,91,8,7.79807E-09
NOG106955,[NoAnn],S,46,5,7.70327E-09
NOG02157,EpsK domain protein,S,39,5,7.1852E-09
COG0508,Dehydrogenase,C,70,5,7.01057E-09
NOG72118,[NoAnn],S,19,6,6.9818E-09
NOG101914,ATP synthase F0 C subunit,C,33,5,6.69452E-09
NOG08941,Arylsulfotransferase (ASST),S,42,5,6.30733E-09
NOG22247,[NoAnn],S,46,5,6.05539E-09
NOG15682,extracellular solute-binding protein family 1,G,40,5,5.8062E-09
NOG81095,Cell wall hydrolase,M,26,5,5.7524E-09
NOG122574,[NoAnn],S,26,5,5.69956E-09
NOG90341,Protein of unknown function (DUF805),S,20,5,5.15576E-09
NOG03239,[NoAnn],S,9,5,5.06912E-09
COG3494,Protein of unknown function (DUF1009),S,44,5,4.93731E-09
NOG116963,ig domain protein group 2 domain protein,S,5,5,4.85444E-09
NOG99039,abrb family transcriptional regulator,K,32,5,4.84213E-09
NOG214335,"ATP synthase f0, c subunit",C,28,7,4.64124E-09
NOG38981,[NoAnn],S,45,5,4.5369E-09
NOG62059,Protein of unknown function (DUF3268),S,75,6,4.51058E-09
COG1914,"H( )-stimulated, divalent metal cation uptake system (By similarity)",P,66,5,4.42369E-09
NOG215665,"transcriptional regulator), MarR family",K,26,5,4.40226E-09
NOG37080,abc transporter atp-binding protein,R,39,5,4.3458E-09
NOG35641,Abc-2 type transporter,V,8,5,4.2998E-09
NOG219215,YceG-like family,S,9,6,4.24996E-09
COG3825,Vwa containing coxe family protein,S,36,5,4.2069E-09
NOG76081,thiamine,H,41,5,4.11633E-09
NOG101676,Type I restriction modification DNA specificity domain,V,29,5,4.09019E-09
COG4947,esterase,R,51,5,4.05637E-09
NOG103691,septum formation initiator,S,27,5,4.04305E-09
NOG100921,"domain protein, FtsQ-type",S,35,5,4.04178E-09
NOG84270,[NoAnn],S,30,5,4.03169E-09
NOG02717,type iii restriction,V,26,5,3.93248E-09
COG1378,Transcriptional regulator,K,41,5,3.89335E-09
NOG213825,Polysaccharide Biosynthesis Protein,M,32,5,3.83674E-09
NOG35387,Transcriptional regulator,K,11,5,3.75106E-09
NOG67492,[NoAnn],S,44,6,3.6462E-09
NOG18639,Nucleotidyl transferase of unknown function (DUF1814),S,37,6,3.64601E-09
COG3347,Short chain dehydrogenase,S,20,5,3.62817E-09
NOG36895,Glycosyl transferase group 1,M,41,5,3.62052E-09
COG3942,CHAP domain protein,S,22,5,3.6202E-09
NOG107131,[NoAnn],S,14,5,3.58292E-09
COG0409,hydrogenase expression formation protein HypD,O,37,5,3.53977E-09
NOG90655,[NoAnn],R,42,5,3.52786E-09
NOG23106,[NoAnn],S,20,5,3.46678E-09
NOG58989,Membrane,S,35,5,3.44581E-09
NOG11921,abc transporter permease protein,V,30,5,3.36562E-09
NOG212445,[NoAnn],S,20,5,3.35054E-09
NOG103518,Modulates RecA activity (By similarity),R,37,5,3.34567E-09
NOG61183,[NoAnn],S,47,5,3.30671E-09
NOG62400,[NoAnn],S,53,5,3.30329E-09
COG0239,Protein CrcB homolog,D,55,5,3.27367E-09
NOG03851,transglutaminase-like protein,S,22,5,3.26399E-09
COG1869,Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity),G,37,5,3.26383E-09
NOG215765,"transcriptional regulator, MarR family",K,56,5,3.24848E-09
NOG81778,[NoAnn],S,40,5,3.24314E-09
COG4821,UPF0309 protein,S,35,5,3.24018E-09
NOG117098,[NoAnn],C,46,5,3.22221E-09
NOG212644,[NoAnn],S,17,5,3.22195E-09
NOG46290,Major Facilitator,G,45,5,3.2189E-09
NOG20288,extracellular solute-binding protein family 1,G,39,5,3.21494E-09
NOG81053,[NoAnn],S,18,5,3.21268E-09
NOG27756,HpaII restriction endonuclease,V,25,5,3.21153E-09
NOG96380,Endodeoxyribonuclease RusA,S,59,7,3.20966E-09
COG2356,endonuclease I,L,30,5,3.18057E-09
NOG108913,[NoAnn],S,41,5,3.14863E-09
NOG05220,[NoAnn],S,7,5,3.11656E-09
NOG190612,Plasmid recombination enzyme,S,5,5,3.11183E-09
COG3953,tail protein,S,37,5,3.0849E-09
NOG72690,saf domain-containing protein,S,72,5,3.08329E-09
COG3860,Transcriptional regulator,K,26,5,3.08281E-09
COG1018,"Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)",C,22,5,3.07708E-09
NOG09460,Plasmid recombination enzyme,S,21,5,3.07065E-09
NOG213918,Redoxin,O,31,5,3.06889E-09
NOG215702,Thioredoxin,O,18,5,3.06585E-09
NOG102552,Protein of unknown function (DUF1312),S,24,5,3.06562E-09
COG2156,"One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)",P,20,5,3.06536E-09
COG1436,Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity),C,71,5,3.06406E-09
NOG10304,conjugative transposon protein,S,30,5,3.05642E-09
COG4448,l-asparaginase ii,E,34,8,3.0533E-09
NOG12590,Protein of unknown function (DUF1273),S,44,5,3.05215E-09
NOG80730,crispr-associated protein,L,36,5,3.04757E-09
COG0818,Diacylglycerol kinase,M,107,5,3.04671E-09
NOG23211,[NoAnn],S,18,5,3.0449E-09
NOG21457,domain protein,M,44,5,3.03667E-09
NOG60163,"hydrolase, family 25",M,29,5,3.02581E-09
NOG77812,[NoAnn],S,39,5,3.01139E-09
COG4548,von Willebrand factor type A,P,46,5,3.00961E-09
NOG18560,n-acetylmuramoyl-l-alanine amidase,M,35,5,3.00956E-09
NOG86512,"acetyltransferase, (GNAT) family",R,20,5,3.00012E-09
NOG106767,[NoAnn],S,28,5,2.98869E-09
NOG216586,This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity),S,20,5,2.98843E-09
NOG122300,[NoAnn],S,14,5,2.98817E-09
NOG105949,Acetyltransferase (GNAT) family,R,22,5,2.96689E-09
COG1793,DNA ligase,L,24,5,2.96449E-09
COG1758,Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity),K,42,5,2.96183E-09
NOG69090,RelB DinJ family addiction module antitoxin,S,17,5,2.9613E-09
NOG33307,OstA family,S,22,5,2.9504E-09
NOG40696,[NoAnn],S,30,5,2.94765E-09
NOG77618,[NoAnn],S,17,5,2.94631E-09
NOG67478,Methyl-accepting chemotaxis,S,31,5,2.9454E-09
COG1047,peptidylprolyl cistrans isomerase,O,60,5,2.92297E-09
NOG16825,transposase,S,29,5,2.91419E-09
NOG29830,TIM-barrel fold,S,88,5,2.90658E-09
NOG00823,Membrane,S,25,5,2.90357E-09
NOG61241,[NoAnn],S,16,5,2.87728E-09
NOG18770,dihydrodipicolinate synthetase,E,21,5,2.86118E-09
NOG13964,[NoAnn],S,33,5,2.86066E-09
NOG51818,Metallo-beta-lactamase superfamily,R,42,5,2.85888E-09
COG0501,Protease HtpX homolog,O,69,5,2.85191E-09
NOG101785,lrga family,R,16,5,2.85013E-09
NOG190469,SCP-2 sterol transfer family,S,42,5,2.83363E-09
NOG15070,Delta-lactam-biosynthetic de-N-acetylase,S,108,5,2.83016E-09
NOG68692,[NoAnn],S,16,5,2.82732E-09
NOG146365,Replication Protein,L,56,5,2.81951E-09
NOG22356,Uncharacterized protein conserved in bacteria (DUF2334),S,37,5,2.80924E-09
NOG34164,permease protein,P,15,5,2.79653E-09
COG3506,Protein of unknown function (DUF1349),S,53,5,2.7898E-09
COG1712,Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity),H,21,5,2.78304E-09
NOG86472,methyltransferase,R,29,5,2.78206E-09
NOG32750,Major capsid protein,R,44,5,2.76371E-09
NOG61141,[NoAnn],S,22,5,2.76259E-09
NOG33730,cyclic nucleotide-binding domain protein,T,50,5,2.75807E-09
NOG156974,Protein of unknown function (DUF1292),S,15,5,2.75078E-09
NOG213486,virulence-like protein,S,79,5,2.74788E-09
NOG94714,[NoAnn],S,29,5,2.73844E-09
NOG78025,[NoAnn],S,27,5,2.73221E-09
NOG111003,[NoAnn],S,19,5,2.70916E-09
NOG213187,AhpC Tsa family,O,32,5,2.70737E-09
NOG34900,[NoAnn],S,10,5,2.69853E-09
NOG212983,[NoAnn],S,63,5,2.69534E-09
COG2104,Thiamine biosynthesis protein thiS,H,27,5,2.69171E-09
NOG11263,PHP domain protein,S,54,5,2.68887E-09
NOG213346,polysaccharide biosynthesis protein,M,25,5,2.68592E-09
NOG153617,Nucleotidyltransferase domain,R,19,5,2.6784E-09
NOG213316,Histidine kinase,T,40,5,2.67704E-09
NOG45629,peptidase m56,R,21,5,2.66421E-09
NOG09733,chromosome segregation atpase,S,59,5,2.65683E-09
NOG41016,DNA-binding helix-turn-helix protein,S,56,5,2.65597E-09
NOG81090,[NoAnn],S,14,5,2.6499E-09
NOG89166,Coat F domain protein,M,64,5,2.64776E-09
NOG59486,[NoAnn],S,87,5,2.64678E-09
NOG84258,transcriptional regulator (AraC family),K,8,5,2.63829E-09
NOG219969,Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity),T,31,5,2.62735E-09
NOG31545,Phage recombination protein Bet,L,44,6,2.6238E-09
NOG92435,Negative regulator of genetic competence (MecA),S,31,5,2.61232E-09
NOG71448,Protein of unknown function (DUF1113),S,14,5,2.59909E-09
NOG05154,Major Facilitator,G,29,5,2.58724E-09
NOG26501,Transcriptional regulator,K,84,5,2.56802E-09
NOG87054,[NoAnn],S,41,5,2.56722E-09
NOG96594,Transcriptional regulator,K,13,5,2.55897E-09
NOG60264,C_GCAxxG_C_C family,S,23,5,2.55861E-09
NOG04442,"Transcriptional regulator, TetR family",K,13,5,2.5586E-09
COG1749,"flagellar hook protein, FlgE",N,88,5,2.55859E-09
NOG217433,Preprotein translocase SecG subunit,U,22,5,2.55058E-09
COG4972,type IV pilus assembly protein pilm,N,57,5,2.55033E-09
NOG94006,Cell Wall Hydrolase,M,24,5,2.54451E-09
NOG48684,"transcriptional regulator, MarR family",K,68,5,2.54416E-09
NOG24812,n-acetylmuramoyl-l-alanine amidase,M,34,5,2.5297E-09
NOG84361,Prokaryotic N-terminal methylation motif,U,55,5,2.52629E-09
NOG47954,n-acetylmuramoyl-l-alanine amidase,M,11,5,2.52129E-09
NOG13237,Type II restriction,V,29,5,2.51493E-09
NOG21227,[NoAnn],S,45,5,2.50598E-09
NOG77292,Plasmid stabilization system,R,58,5,2.50509E-09
NOG32237,LysR family (Transcriptional regulator,K,27,5,2.48587E-09
COG0405,Gamma-glutamyltranspeptidase (EC 2.3.2.2),E,75,5,2.47679E-09
NOG221901,[NoAnn],S,25,5,2.44904E-09
NOG72814,Accessory gene regulator B,S,23,5,2.44514E-09
NOG216212,Domain of unknown function (DUF1858),S,31,5,2.44409E-09
COG1254,Acylphosphatase (EC 3.6.1.7),C,45,5,2.44044E-09
NOG73948,Transcriptional regulator GntR family,K,26,5,2.44033E-09
NOG25386,[NoAnn],S,41,5,2.43202E-09
NOG218189,DNA polymerase iii,L,33,5,2.43112E-09
NOG34484,HNH nuclease,V,17,5,2.43088E-09
NOG10353,Transcriptional regulator,K,38,5,2.42232E-09
COG3069,C4-dicarboxylate transporter,C,46,5,2.42044E-09
NOG15410,[NoAnn],S,26,5,2.41727E-09
NOG52405,[NoAnn],S,16,5,2.41661E-09
COG5527,replication protein,L,19,5,2.41571E-09
NOG104438,[NoAnn],S,28,5,2.41185E-09
COG1615,UPF0182 protein,S,46,5,2.41041E-09
NOG79832,[NoAnn],S,34,5,2.40571E-09
NOG02359,Transporter,G,17,5,2.40435E-09
NOG214673,Transporter major facilitator family,G,9,5,2.40252E-09
NOG31603,[NoAnn],S,30,5,2.39876E-09
NOG02172,Protein of unknown function (DUF1177),S,23,5,2.39789E-09
COG3707,response regulator,T,45,5,2.39412E-09
NOG16301,[NoAnn],S,21,5,2.39327E-09
NOG80708,MarR family Transcriptional regulator,K,18,5,2.37942E-09
NOG04443,AraC family transcriptional regulator,K,62,5,2.37798E-09
COG1852,Protein of unknown function DUF116,S,19,5,2.37715E-09
NOG67689,[NoAnn],S,42,5,2.37557E-09
NOG00394,Short-chain dehydrogenase reductase Sdr,R,13,5,2.37287E-09
NOG215328,[NoAnn],S,23,5,2.35365E-09
COG1728,Protein of unknown function (DUF327),S,37,5,2.34523E-09
NOG104246,"holin, phage phi LC3 family",S,38,5,2.34522E-09
NOG26849,Crispr-associated ramp protein,L,24,5,2.34433E-09
COG1240,magnesium chelatase,H,22,5,2.34198E-09
COG3560,Nitroreductase,R,23,5,2.33679E-09
NOG212687,Family of unknown function (DUF490),S,32,5,2.32973E-09
NOG51549,Glycosyl transferase family protein,M,37,5,2.32841E-09
NOG185079,Bacterial Ig-like domain (group 2),S,31,5,2.32528E-09
NOG83934,[NoAnn],S,31,5,2.3251E-09
NOG41554,[NoAnn],S,23,5,2.3224E-09
NOG57428,frg domain protein,S,56,5,2.32084E-09
NOG17907,[NoAnn],S,39,5,2.30631E-09
NOG49464,[NoAnn],S,17,5,2.30548E-09
NOG211964,Xylose isomerase domain protein TIM barrel,G,15,5,2.30163E-09
NOG85204,rna polymerase alpha,K,21,5,2.29935E-09
NOG91953,[NoAnn],S,33,5,2.29846E-09
NOG46832,s-layer protein,S,38,5,2.29812E-09
NOG25654,transcriptional regulator laci family,K,30,5,2.28415E-09
NOG133100,Domain of unknown function (DUF305),S,19,5,2.28354E-09
NOG91517,"Transcriptional regulator, ARAC family",K,15,5,2.28198E-09
NOG226520,Pfam:Complex1_24kDa,S,37,5,2.28159E-09
COG0694,"Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)",O,66,5,2.27385E-09
COG2361,Protein of unknown function DUF86,S,72,5,2.26399E-09
NOG32026,family 11,M,30,5,2.26381E-09
NOG219102,Helix-turn-helix,S,50,5,2.26215E-09
NOG195658,[NoAnn],S,6,5,2.26181E-09
COG4279,"Zinc finger, swim domain protein",S,24,5,2.26121E-09
NOG121621,[NoAnn],S,31,5,2.25848E-09
NOG05720,(ABC) transporter,G,63,5,2.25588E-09
NOG104670,signal peptidase,U,38,5,2.25419E-09
NOG144974,[NoAnn],S,35,5,2.25295E-09
COG4862,Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis,O,23,5,2.25154E-09
NOG136035,[NoAnn],S,64,5,2.24774E-09
NOG101590,rRNA biogenesis protein Rrp5,S,131,5,2.24715E-09
COG5551,CRISPR-associated protein cas6,S,59,5,2.2416E-09
COG2971,ATPase BadF BadG BcrA BcrD type,G,34,5,2.23958E-09
COG1251,nitrite reductase,C,28,5,2.23585E-09
NOG87582,Transcriptional regulator,K,18,5,2.2341E-09
NOG99773,[NoAnn],S,32,5,2.23371E-09
NOG112569,[NoAnn],S,18,5,2.23001E-09
NOG01095,[NoAnn],S,16,5,2.22952E-09
NOG12002,RNA methylase,L,24,5,2.22857E-09
NOG00513,[NoAnn],S,24,5,2.22598E-09
NOG06837,[NoAnn],S,38,5,2.22401E-09
NOG36972,[NoAnn],S,31,5,2.22325E-09
NOG14768,serine threonine protein,T,11,5,2.22149E-09
COG0804,Urea amidohydrolase subunit alpha,E,26,5,2.22126E-09
NOG102006,UPF0291 protein,S,59,5,2.22114E-09
NOG53134,ribonuclease M5,S,42,5,2.22031E-09
NOG00454,Acetyltransferase (GNAT) family,R,15,5,2.22007E-09
NOG74008,[NoAnn],S,18,5,2.21997E-09
NOG65926,[NoAnn],S,20,5,2.21981E-09
NOG66884,[NoAnn],S,26,5,2.21966E-09
COG0247,domain protein,C,41,5,2.21843E-09
NOG57399,PHP domain protein,S,68,5,2.21783E-09
NOG08431,(Lipo)protein,S,41,5,2.21755E-09
NOG84217,[NoAnn],S,36,5,2.21645E-09
NOG03909,helicase domain protein,L,53,5,2.21532E-09
NOG213819,methyltransferase,R,10,5,2.21496E-09
NOG214900,Transcriptional regulator,K,16,5,2.21493E-09
NOG63147,[NoAnn],S,24,5,2.21397E-09
NOG01002,oxidoreductase,R,41,5,2.21355E-09
NOG27106,coat protein,S,67,5,2.21298E-09
COG2096,Adenosyltransferase,S,34,5,2.21294E-09
COG2066,Glutaminase,E,31,5,2.21291E-09
NOG34682,Fructoselysine 6-kinase,G,13,5,2.21262E-09
NOG35000,Tripartite ATP-independent periplasmic transporter,P,24,5,2.21258E-09
COG4956,PilT protein domain protein,R,66,5,2.21238E-09
NOG104238,"Uncharacterized ACR, COG1399",R,33,5,2.21112E-09
COG4694,[NoAnn],S,38,5,2.21087E-09
NOG05466,domain protein,S,31,5,2.21074E-09
NOG08725,[NoAnn],S,34,5,2.21059E-09
COG1280,Lysine exporter protein (Lyse ygga),E,46,5,2.21053E-09
NOG101957,ig domain protein group 2 domain protein,S,59,5,2.20993E-09
NOG63823,[NoAnn],S,32,5,2.2099E-09
NOG87035,TM2 domain containing protein,S,17,5,2.20973E-09
NOG09794,NERD domain protein,S,29,5,2.20972E-09
NOG214739,methyltransferase,R,32,5,2.2096E-09
NOG208718,[NoAnn],S,29,5,2.20958E-09
COG3965,cation diffusion facilitator family transporter,P,32,5,2.20954E-09
NOG49274,[NoAnn],S,16,5,2.2095E-09
NOG218153,[NoAnn],S,12,5,2.20927E-09
COG2987,Urocanate hydratase,E,32,5,2.20916E-09
NOG01033,Nucleotidyl transferase of unknown function (DUF1814),S,65,5,2.20907E-09
NOG101842,Integral membrane protein CcmA involved in cell shape,S,20,5,2.20901E-09
COG1359,Antibiotic biosynthesis monooxygenase,S,34,5,2.20894E-09
NOG79275,[NoAnn],S,59,5,2.20892E-09
NOG10062,ATP-dependent OLD family endonuclease,S,21,5,2.20874E-09
NOG103648,[NoAnn],S,39,5,2.20858E-09
NOG45803,[NoAnn],S,20,5,2.2083E-09
NOG04338,fad dependent oxidoreductase,R,32,5,2.20786E-09
COG5441,UPF0261 protein,S,23,5,2.20782E-09
NOG217638,Transcriptional regulator,K,23,5,2.20777E-09
NOG84968,drtgg domain-containing protein,S,30,5,2.20774E-09
COG2813,Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity),J,77,5,2.20773E-09
NOG103466,UPF0109 protein,S,25,5,2.20772E-09
COG1085,galactose-1-phosphate uridylyltransferase,G,32,5,2.20764E-09
NOG53807,Domain of unknown function (DUF955),R,13,5,2.20761E-09
COG3543,Iron-sulfur binding protein,S,32,5,2.20742E-09
NOG56292,[NoAnn],S,42,5,2.20731E-09
NOG130759,"transcriptional regulator, AraC family",K,13,5,2.2073E-09
NOG110572,XRE family transcriptional regulator,K,20,5,2.20728E-09
NOG32025,[NoAnn],S,45,5,2.20721E-09
NOG68123,Protein of unknown function (DUF1351),S,50,5,2.20715E-09
NOG06934,methyltransferase,R,21,5,2.20707E-09
NOG14304,[NoAnn],S,16,5,2.20702E-09
NOG218984,Flagellar hook capping protein,N,14,5,2.20697E-09
NOG02962,Membrane,S,35,5,2.20696E-09
NOG215891,PilZ domain,S,17,5,2.20696E-09
NOG30222,[NoAnn],S,28,5,2.20693E-09
NOG102536,domain protein,S,10,5,2.20675E-09
NOG32771,Transcriptional regulator,K,20,5,2.2067E-09
NOG75763,S-layer protein,S,42,5,2.20666E-09
NOG89558,"transcriptional regulator, araC family",K,7,5,2.20658E-09
NOG185898,Condensation domain,S,11,5,2.20637E-09
NOG29556,Aaa atpase,R,23,5,2.20634E-09
NOG222725,Protein of unknown function (DUF3486),S,20,5,2.2063E-09
NOG66224,[NoAnn],S,57,5,2.2063E-09
NOG106781,[NoAnn],S,25,5,2.20625E-09
NOG48093,Glycosyl transferase group 1,M,21,5,2.20621E-09
NOG94014,[NoAnn],S,22,5,2.2062E-09
NOG22109,Sulfite exporter TauE/SafE,S,21,5,2.20618E-09
COG3775,"PTS system, galactitol-specific IIc component",G,35,5,2.20616E-09
NOG18657,[NoAnn],S,42,5,2.20612E-09
NOG80519,[NoAnn],S,44,5,2.20609E-09
NOG101905,Flagellar hook-length control protein,N,18,5,2.20607E-09
NOG101510,Ferredoxin,C,20,5,2.20602E-09
COG0455,site-determining protein,D,30,5,2.20599E-09
COG4964,Type II and III secretion system protein,U,25,5,2.2058E-09
NOG35253,(ABC) transporter,R,19,5,2.20579E-09
COG5518,portal protein,R,18,5,2.20575E-09
NOG40406,[NoAnn],S,25,5,2.20573E-09
NOG09101,Phosphoenolpyruvate carboxykinase (ATP),C,28,5,2.20569E-09
NOG212688,lipolytic enzyme,S,15,5,2.20565E-09
COG1767,triphosphoribosyl-dephospho-CoA synthase,H,32,5,2.20563E-09
COG4748,type I restriction enzyme,V,41,5,2.20552E-09
NOG07555,[NoAnn],S,17,5,2.20551E-09
NOG80175,Peptidase U32,R,16,5,2.2055E-09
NOG25342,[NoAnn],S,50,5,2.20548E-09
NOG189919,[NoAnn],S,18,5,2.20548E-09
NOG41348,Dinitrogenase iron-molybdenum cofactor,S,47,5,2.20545E-09
COG0774,"involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)",M,24,5,2.20543E-09
NOG82583,[NoAnn],S,23,5,2.20542E-09
COG4098,Competence protein,L,31,5,2.2054E-09
NOG80924,"Conserved domain protein, histidine-rich",S,70,5,2.20539E-09
NOG02870,Membrane,S,52,5,2.20535E-09
NOG34505,[NoAnn],S,38,5,2.20532E-09
NOG85688,Global regulator protein family,S,34,5,2.20532E-09
COG4043,ProFAR isomerase,S,34,5,2.20531E-09
NOG02977,Abc-2 type transporter,V,25,5,2.20524E-09
NOG41560,"In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination",C,26,5,2.20524E-09
NOG39149,[NoAnn],S,23,5,2.20524E-09
NOG30112,"acetyltransferase, (GNAT) family",R,42,5,2.20524E-09
COG5617,Membrane,S,22,5,2.20523E-09
COG3815,Predicted membrane protein (DUF2085),S,17,5,2.20521E-09
NOG149965,[NoAnn],S,20,5,2.2052E-09
NOG81722,[NoAnn],S,25,5,2.20519E-09
NOG65614,[NoAnn],S,22,5,2.20518E-09
COG2929,Protein of unknown function (DUF497),S,40,5,2.20518E-09
NOG104684,[NoAnn],S,25,5,2.20518E-09
COG3493,citrate carrier protein,C,26,5,2.20518E-09
NOG01113,penicillin-binding protein,M,41,5,2.20517E-09
COG1338,Flagellar biosynthetic protein FliP,N,56,5,2.20516E-09
COG1487,Toxic component of a toxin-antitoxin (TA) module. A,R,29,5,2.20516E-09
NOG212261,[NoAnn],S,73,5,2.20516E-09
NOG09680,Polysaccharide Biosynthesis Protein,M,43,5,2.20516E-09
NOG99907,[NoAnn],S,11,5,2.20515E-09
NOG102765,[NoAnn],S,30,5,2.20515E-09
NOG214565,[NoAnn],S,19,5,2.20515E-09
NOG14932,methionine adenosyltransferase,S,34,5,2.20514E-09
NOG62574,spore coat protein GerQ,S,31,5,2.20514E-09
COG3763,UPF0154 protein,S,36,5,2.20514E-09
COG0832,Urea amidohydrolase subunit beta,E,23,5,2.20514E-09
NOG139156,Transcriptional,K,21,5,2.20513E-09
NOG03639,Periplasmic binding protein LacI transcriptional regulator,G,27,5,2.20513E-09
NOG81238,1-acyl-sn-glycerol-3-phosphate acyltransferase,S,29,5,2.20513E-09
NOG211919,Major Facilitator,G,22,5,2.20512E-09
NOG123981,[NoAnn],R,27,5,2.20512E-09
NOG19270,Uncharacterized conserved protein (DUF2075),S,29,5,2.20512E-09
NOG214233,Diguanylate phosphodiesterase,T,8,5,2.20512E-09
NOG43685,[NoAnn],S,24,5,2.20512E-09
NOG28670,membrAne,S,30,5,2.20512E-09
NOG18297,Type II site-specific deoxyribonuclease,V,37,5,2.20512E-09
NOG219202,[NoAnn],S,33,5,2.20512E-09
NOG161111,[NoAnn],S,9,5,2.20512E-09
COG3595,[NoAnn],S,18,5,2.20512E-09
COG1834,amidinotransferase,E,19,5,2.20512E-09
NOG18846,"extracellular solute-binding protein, family 1",G,25,5,2.20512E-09
NOG217210,[NoAnn],S,72,5,2.20512E-09
NOG222322,[NoAnn],L,40,5,2.20511E-09
NOG63285,Stage iii sporulation protein,S,43,5,2.20511E-09
NOG26976,[NoAnn],S,61,5,2.20511E-09
NOG218698,alkaline phosphatase,R,30,5,2.20511E-09
NOG10458,PHP domain protein,S,34,5,2.20511E-09
NOG99452,Transcriptional regulator,K,12,5,2.20511E-09
NOG13018,LPXTG-motif cell wall anchor domain protein,S,36,5,2.20511E-09
NOG214123,Membrane,S,55,5,2.20511E-09
NOG79803,Flagellar protein,S,32,5,2.20511E-09
NOG87910,tetratricopeptide repeat protein,R,23,5,2.20511E-09
NOG63590,"histidinol phosphate phosphatase, hisj family",E,16,5,2.20511E-09
NOG219508,HTH_XRE,K,54,6,1.93579E-09
COG3325,chitinase,G,35,6,1.77838E-09
COG3566,bacteriophage protein,S,64,6,1.67484E-09
NOG216723,Heavy-metal-associated domain,P,13,7,1.65874E-09
NOG33457,[NoAnn],S,39,6,1.44698E-09
NOG14947,FAD binding domain in molybdopterin dehydrogenase,C,57,7,1.42016E-09
NOG101189,"Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)",L,43,6,1.37237E-09
NOG02248,Transposase (IS4 family,L,28,6,1.2909E-09
NOG49248,gCN5-related N-acetyltransferase,R,35,6,1.08849E-09
COG1380,lrga family,R,98,10,1.05259E-09
NOG216451,[NoAnn],S,45,7,9.68001E-10
NOG41190,Spore Coat Protein,M,51,6,9.40877E-10
NOG213859,Transcriptional regulator,K,18,16,8.75316E-10
NOG14259,[NoAnn],S,70,6,8.61225E-10
COG0819,"Transcriptional activator, tena",K,37,7,8.4223E-10
NOG97466,[NoAnn],S,68,12,7.42173E-10
COG0811,MotA TolQ exbB proton channel,U,66,7,5.98722E-10
NOG07048,[NoAnn],S,52,6,5.93971E-10
NOG231217,"DNA polymerase III, delta subunit",L,11,6,5.72629E-10
NOG44770,"hemerythrin-like, metal-binding protein",S,29,6,5.49653E-10
NOG90605,Domain of unknown function (DUF955),S,51,7,5.1154E-10
NOG62389,xre family,K,48,6,5.0932E-10
NOG215303,Transcriptional regulator,K,43,6,5.03927E-10
COG1567,"CRISPR-associated RAMP protein, Csm4 family",L,44,6,4.85053E-10
NOG16211,[NoAnn],S,32,6,4.78513E-10
NOG59441,[NoAnn],S,17,6,4.39916E-10
NOG06606,[NoAnn],S,84,6,3.82284E-10
COG2910,Nad-dependent epimerase dehydratase,R,57,7,3.78494E-10
NOG17142,[NoAnn],S,24,7,3.65234E-10
NOG87617,[NoAnn],S,67,6,3.53612E-10
COG1983,phage shock protein C,K,63,6,3.45181E-10
COG1426,Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity),S,31,6,3.38986E-10
NOG214385,alginate O-acetyltransferase,S,37,6,3.30089E-10
NOG100754,HTH_XRE,S,42,7,3.23674E-10
NOG02602,CobQ/CobB/MinD/ParA nucleotide binding domain,S,71,6,3.14653E-10
COG3457,Racemase,E,46,8,3.0787E-10
NOG78215,Protein of unknown function (DUF1071),S,60,6,2.81066E-10
NOG46581,O-acyl-ADP-ribose deacylase 1,R,23,6,2.76422E-10
NOG50663,[NoAnn],S,56,7,2.5641E-10
NOG83094,[NoAnn],S,40,6,2.41265E-10
NOG115378,[NoAnn],S,51,7,2.39872E-10
NOG11559,Glycoside hydrolase family 2 sugar binding,G,32,6,2.32208E-10
NOG01265,Arylsulfotransferase (ASST),S,25,6,2.15323E-10
COG0011,conserved protein,S,32,6,2.1331E-10
COG1406,chemotaxis protein,N,24,8,1.97545E-10
NOG110391,VRR-NUC domain-containing protein,S,53,6,1.95719E-10
COG5663,nucleotidase,S,41,6,1.95598E-10
NOG43257,"transcriptional regulator), MarR family",K,84,6,1.93605E-10
COG1174,(ABC) transporter,E,53,6,1.86181E-10
NOG101974,Rhodanese domain protein,R,25,6,1.84097E-10
COG3231,Aminoglycoside,J,18,6,1.7555E-10
NOG34314,[NoAnn],S,54,6,1.74219E-10
COG3735,gumn family,S,22,7,1.72918E-10
NOG05160,transposase,L,52,6,1.66637E-10
COG3772,lysozyme,R,58,6,1.66366E-10
COG4271,nucleotide-binding protein,K,37,6,1.66069E-10
NOG128162,[NoAnn],R,14,6,1.64381E-10
COG1984,Allophanate hydrolase subunit 2,E,39,6,1.63014E-10
NOG65181,Transcriptional regulator,K,38,6,1.62353E-10
NOG59999,transposase,L,65,6,1.61916E-10
NOG101890,"Addiction module antitoxin, RelB DinJ family",S,36,6,1.60236E-10
NOG101418,SCP-like extracellular,S,46,8,1.57723E-10
NOG50584,"Addiction module antitoxin, RelB DinJ family",S,45,6,1.55824E-10
NOG98104,[NoAnn],S,10,6,1.55636E-10
NOG130651,[NoAnn],S,22,6,1.53907E-10
NOG79170,UvrD REP helicase,S,34,6,1.53709E-10
COG4887,metal-binding protein,S,48,6,1.52424E-10
COG0074,Succinyl-CoA ligase ADP-forming subunit alpha,C,31,6,1.5234E-10
NOG219671,Cell wall-active antibiotics response protein (DUF2154),S,29,6,1.47746E-10
COG4470,Transcriptional regulator,S,45,6,1.4543E-10
NOG82878,Macro domain,S,21,6,1.44427E-10
NOG80102,[NoAnn],V,28,7,1.44304E-10
NOG79921,"small, acid-soluble spore protein",R,50,6,1.43384E-10
NOG90101,[NoAnn],S,34,6,1.42586E-10
NOG29146,[NoAnn],S,42,6,1.40699E-10
NOG85494,Plasmid stabilization system,R,25,6,1.39997E-10
NOG34581,[NoAnn],S,37,6,1.39958E-10
NOG102854,Membrane protein implicated in regulation of membrane protease activity,S,18,6,1.39731E-10
NOG24182,Phage capsid family ,R,51,9,1.39547E-10
NOG04939,Cytidylyltransferase,S,40,6,1.39269E-10
NOG40816,[NoAnn],S,46,6,1.38478E-10
NOG212632,[NoAnn],R,21,6,1.38379E-10
COG0611,"Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)",H,18,6,1.38332E-10
NOG04131,domain) protein,S,52,6,1.38072E-10
NOG85274,[NoAnn],S,16,6,1.38029E-10
NOG101939,TM2 domain,S,33,6,1.37467E-10
NOG212035,cellulose-binding family II protein,G,26,6,1.3703E-10
NOG212365,[NoAnn],S,31,6,1.36968E-10
NOG07395,[NoAnn],S,49,6,1.36855E-10
COG2057,Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity),I,40,6,1.36719E-10
NOG06804,Integrase,L,44,6,1.36567E-10
NOG212259,beta-lactamase domain protein,R,14,6,1.36269E-10
COG3293,transposase,L,57,6,1.35385E-10
NOG80065,[NoAnn],L,35,6,1.34638E-10
COG3579,aminopeptidase c,E,52,6,1.34393E-10
COG4907,(Membrane protein)-like protein,S,46,6,1.34243E-10
NOG81157,[NoAnn],S,27,6,1.329E-10
NOG31304,[NoAnn],S,58,6,1.32766E-10
NOG87028,peptidase M15A,R,35,6,1.32466E-10
NOG42998,"lipoprotein LpqB, GerMN",R,36,6,1.3217E-10
NOG22810,[NoAnn],S,21,6,1.31841E-10
NOG39519,"acetyltransferase, (GNAT) family",R,21,6,1.31018E-10
COG0805,"Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)",U,45,6,1.29926E-10
COG1226,PotAssium voltage-gated channel,P,63,6,1.2982E-10
NOG39255,Histidine kinase,T,43,6,1.29504E-10
NOG50093,[NoAnn],S,50,6,1.28476E-10
NOG66062,PilZ domain,S,22,6,1.27352E-10
NOG90248,prevent-host-death family,S,26,6,1.26912E-10
NOG52871,s-layer domain protein,S,28,6,1.26659E-10
NOG84769,[NoAnn],S,20,6,1.26011E-10
NOG83166,lysm domain,S,19,6,1.24351E-10
NOG68375,"Glycosyl hydrolase, family 25",M,24,6,1.24212E-10
NOG00390,"The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity)",P,33,6,1.23935E-10
NOG215698,DNA-binding helix-turn-helix protein,S,87,10,1.22951E-10
COG3689,transporter substrate-binding protein,S,58,6,1.22664E-10
NOG30262,[NoAnn],S,42,6,1.22628E-10
NOG122441,"Primosome, DnaD subunit",L,36,6,1.22095E-10
NOG17066,GH3 auxin-responsive promoter,S,14,6,1.21747E-10
NOG14324,[NoAnn],S,24,6,1.21676E-10
NOG94968,Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity),D,29,6,1.20141E-10
NOG53255,[NoAnn],S,56,6,1.19784E-10
COG3919,ATP-grasp,S,73,6,1.19579E-10
COG0751,Glycyl-tRNA synthetase beta subunit,J,59,6,1.19255E-10
NOG22841,Transcriptional regulator,K,55,6,1.19184E-10
NOG31563,Chloramphenicol O-acetyltransferase,V,49,6,1.18715E-10
NOG51653,methyltransferase,R,41,6,1.18591E-10
COG2885,ompa motb domain protein,M,37,6,1.18246E-10
NOG86654,"Toxin-antitoxin system, antitoxin component",S,58,6,1.18222E-10
NOG32591,Replication initiator protein A,L,115,6,1.18136E-10
COG3066,Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity),L,35,6,1.1753E-10
NOG52375,sporulation protein ytfj,S,47,6,1.1681E-10
NOG11709,"Transcriptional regulator, luxr family",K,19,6,1.16697E-10
COG0386,glutathione peroxidase,O,41,6,1.1657E-10
NOG67530,"Protein of unknown function, DUF624",S,45,6,1.16222E-10
NOG95687,[NoAnn],S,15,6,1.1478E-10
NOG50873,[NoAnn],S,25,6,1.1344E-10
COG1560,lipid a biosynthesis,M,54,6,1.13156E-10
NOG90037,[NoAnn],S,18,6,1.12942E-10
NOG139128,[NoAnn],R,61,6,1.12418E-10
NOG46304,domain protein,S,26,6,1.12296E-10
NOG64856,Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily,R,33,6,1.12225E-10
NOG88610,permease,R,37,6,1.12053E-10
NOG110314,HATPase_c,T,28,6,1.11893E-10
NOG88690,[NoAnn],S,35,6,1.11281E-10
NOG07368,(ABC) transporter,R,22,6,1.10676E-10
COG1842,Phage shock protein A,K,49,6,1.09956E-10
NOG197132,transcriptional regulators,K,48,6,1.09684E-10
COG1738,Membrane,S,26,6,1.08459E-10
NOG79124,[NoAnn],S,32,6,1.08185E-10
NOG216704,Hnh endonuclease,V,23,6,1.07721E-10
NOG116658,[NoAnn],S,15,6,1.07248E-10
NOG11297,Binding-protein-dependent transport systems inner membrane component,P,43,6,1.07048E-10
NOG36989,Tim44-like domain,S,22,7,1.06726E-10
NOG183027,"toxin-antitoxin system, antitoxin component, Xre family",S,51,6,1.06477E-10
COG1987,Flagellar biosynthetic protein fliq,N,33,6,1.06413E-10
NOG131096,[NoAnn],R,13,6,1.06203E-10
NOG214972,RelB antitoxin,L,33,8,1.05568E-10
NOG89052,Uncharacterized protein conserved in bacteria (DUF2313),S,44,6,1.05441E-10
COG0848,Biopolymer transport protein exbD tolR,U,23,6,1.05359E-10
COG2957,Agmatine deiminase,E,57,6,1.05226E-10
NOG61866,uptake regulation,S,66,6,1.046E-10
NOG03269,"Trap dicarboxylate transporter, dctp subunit",G,34,6,1.04443E-10
NOG76518,Transcriptional regulator AbrB family,K,37,6,1.04118E-10
NOG74167,Plasmid stabilization system,S,43,6,1.03618E-10
NOG205063,[NoAnn],S,46,6,1.03415E-10
NOG09682,[NoAnn],S,27,6,1.03219E-10
NOG214136,stage III sporulation protein AE,S,42,6,1.02969E-10
COG1536,"FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)",N,58,6,1.02552E-10
COG1835,Acyltransferase,I,40,6,1.02366E-10
NOG88753,HNH endonuclease,V,25,6,1.02349E-10
NOG19118,[NoAnn],S,42,6,1.02267E-10
NOG80910,Protein of unknown function (DUF2812),S,22,6,1.02259E-10
NOG70266,[NoAnn],S,49,7,1.02133E-10
NOG18578,[NoAnn],S,62,6,1.02051E-10
COG1125,(ABC) transporter,E,54,6,1.01424E-10
COG4245,von Willebrand factor type A,R,54,6,1.01289E-10
NOG01912,[NoAnn],S,30,6,1.00761E-10
NOG01135,oxidoreductase,R,17,6,1.00686E-10
NOG00954,Transcriptional regulator,K,38,6,1.00467E-10
COG1732,(ABC) transporter,E,49,6,1.00197E-10
NOG109972,[NoAnn],S,42,6,1.00101E-10
NOG00578,Binding-protein-dependent transport systems inner membrane component,P,52,6,1.00091E-10
NOG189876,HTH_XRE,R,45,6,9.99647E-11
COG3738,"NADH, ubiquinone oxidoreductase",S,50,6,9.98196E-11
NOG87391,[NoAnn],S,51,6,9.97242E-11
NOG83530,Protein of unknown function (DUF1292),S,49,6,9.94151E-11
NOG21480,Sulfatase,R,22,6,9.92632E-11
NOG01475,epimerase dehydratase,R,33,6,9.91585E-11
NOG86476,[NoAnn],S,29,6,9.91472E-11
COG3955,Domain of unknown function (DUF1919),M,46,6,9.89911E-11
NOG102305,Acylphosphatase,C,37,6,9.89224E-11
COG3208,Thioesterase,Q,35,6,9.87108E-11
NOG212337,"Integrase, catalytic region",L,45,6,9.83827E-11
NOG107445,domain protein,R,37,6,9.81796E-11
NOG05549,"transcriptional regulator, araC family",K,31,6,9.80993E-11
NOG67263,Transcriptional regulator,K,28,6,9.80741E-11
COG3664,Glycoside hydrolase family,G,64,6,9.79486E-11
NOG86766,MobA-related protein,S,34,6,9.78966E-11
NOG07293,Transcriptional regulator,K,23,6,9.78571E-11
NOG38477,"transcriptional regulator, tetr family",K,13,6,9.76996E-11
COG0043,Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity),H,45,6,9.76157E-11
COG1291,MotA TolQ exbB proton channel,N,77,6,9.76019E-11
NOG82568,"acetyltransferase, (GNAT) family",R,25,6,9.73995E-11
NOG89672,tigr02206,S,22,6,9.73492E-11
NOG05235,acetyl xylan esterase,S,26,6,9.7236E-11
NOG02574,Iron-sulfur cluster binding protein,S,63,6,9.72355E-11
NOG43291,pyridoxamine 5'-phosphate,R,18,6,9.71447E-11
NOG44418,[NoAnn],S,53,6,9.71301E-11
COG1337,Crispr-associated ramp protein,L,46,6,9.70815E-11
COG1429,"cobaltochelatase, cobn subunit",H,53,6,9.6804E-11
NOG10111,domain protein,S,62,6,9.6671E-11
NOG222010,Phage terminase large subunit,R,33,6,9.66321E-11
COG3604,Transcriptional regulator,K,17,6,9.66226E-11
COG1069,ribulokinase,G,34,6,9.65974E-11
NOG79900,transferase hexapeptide repeat containing protein,R,19,6,9.64712E-11
NOG53086,response regulator,T,22,6,9.64597E-11
COG4478,integral membrane protein,S,32,6,9.64117E-11
NOG212352,[NoAnn],S,14,6,9.63705E-11
NOG02292,"extracellular solute-binding protein, family 1",G,50,6,9.62812E-11
NOG212299,Histidine kinase,T,18,6,9.62801E-11
NOG09208,restriction endonuclease,V,62,6,9.61732E-11
COG2968,Membrane,S,54,6,9.61703E-11
NOG47650,[NoAnn],S,45,6,9.60549E-11
NOG214911,glycosyltransferase,M,59,6,9.60182E-11
NOG69315,[NoAnn],S,54,6,9.60074E-11
NOG102060,Plasmid stabilization system,S,44,6,9.6003E-11
NOG21464,tail tubular protein B,S,23,6,9.60029E-11
NOG227552,HTH_XRE,R,62,6,9.59738E-11
NOG03732,Protein of unknown function (DUF2961),S,30,6,9.59614E-11
COG3152,Membrane,S,27,6,9.59598E-11
NOG56928,[NoAnn],S,57,6,9.59521E-11
NOG83175,[NoAnn],S,30,6,9.59105E-11
NOG212538,Terminase-like family,S,15,6,9.58523E-11
NOG89071,superfamily I DNA and RNA,L,20,6,9.58157E-11
COG0045,Succinyl-CoA synthetase subunit beta,C,16,6,9.58092E-11
NOG105772,Phage major capsid protein,R,34,6,9.5789E-11
COG4642,whole genome shotgun sequence,S,40,6,9.57878E-11
NOG102874,[NoAnn],S,22,6,9.57831E-11
NOG01153,O-Antigen Polymerase,S,29,6,9.57708E-11
NOG87364,colicin V production protein,S,44,6,9.575E-11
NOG00901,Protein of unknown function (DUF1446),S,28,6,9.5747E-11
COG0853,Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity),H,56,6,9.57344E-11
NOG81318,heptaprenyl diphosphate synthase component I,S,47,6,9.56888E-11
NOG82010,DNA packaging protein,L,51,6,9.56586E-11
NOG74268,Enterolysin A,S,57,6,9.56507E-11
NOG83328,[NoAnn],S,25,6,9.56501E-11
COG3053,(citrate (pro-3S)-lyase ligase,C,48,6,9.56497E-11
NOG48380,PHP domain protein,S,10,6,9.56472E-11
NOG03778,Domain of unknown function(DUF2779),S,26,6,9.56428E-11
NOG213729,Transcriptional regulator,K,29,6,9.56364E-11
COG3538,conserved protein,S,21,6,9.56288E-11
NOG21600,Protein of unknown function DUF58,S,36,6,9.56177E-11
COG3044,ABC transporter ATPase,R,78,6,9.56092E-11
NOG01594,methyl-accepting chemotaxis protein,S,36,6,9.56026E-11
COG1419,Flagellar biosynthesis regulator FlhF,N,36,6,9.55919E-11
COG2216,"One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)",P,30,6,9.55888E-11
NOG03842,"ABC transporter, ATP-binding protein",R,50,6,9.55818E-11
COG1540,lamb ycsf family protein,R,50,6,9.55772E-11
NOG04126,Membrane,S,27,6,9.55765E-11
NOG00082,Short-chain dehydrogenase reductase Sdr,R,71,6,9.55679E-11
NOG218207,Collagen triple helix repeat (20 copies),S,31,6,9.55606E-11
NOG78301,[NoAnn],S,31,6,9.55582E-11
NOG106219,wecb taga cpsf family,M,23,6,9.55581E-11
NOG212920,[NoAnn],S,53,6,9.55565E-11
NOG64372,[NoAnn],S,17,6,9.55547E-11
NOG101780,arsR family transcriptional regulator,K,39,6,9.55538E-11
NOG79891,(AraC family) transcriptional regulator,K,22,6,9.55516E-11
NOG02820,reductase complex component C,C,23,6,9.5545E-11
NOG04102,Transcriptional regulator (AraC family),K,79,6,9.55443E-11
NOG215691,Flagellar hook-length control protein,S,27,6,9.55441E-11
NOG181949,[NoAnn],S,41,6,9.55426E-11
NOG70209,[NoAnn],S,35,6,9.55371E-11
NOG214971,php domain-containing protein,S,26,6,9.55316E-11
NOG81414,"transcriptional regulator, merr family",K,25,6,9.55279E-11
NOG05300,Citrate transporter,R,36,6,9.55261E-11
NOG39543,[NoAnn],S,47,6,9.55226E-11
NOG49911,[NoAnn],S,41,6,9.55174E-11
COG1300,stage II sporulation protein m,S,39,6,9.55173E-11
NOG89744,[NoAnn],S,46,6,9.55159E-11
NOG212264,oxidoreductase,R,46,6,9.55144E-11
NOG86375,Xylose isomerase-like TIM barrel,G,29,6,9.55142E-11
NOG215163,methyl-accepting chemotaxis protein,S,22,6,9.5514E-11
NOG30068,Bacterial extracellular solute-binding protein,R,30,6,9.55113E-11
NOG02493,[NoAnn],S,23,6,9.551E-11
NOG51233,[NoAnn],S,41,6,9.55096E-11
NOG187064,integrase family,L,45,6,9.55094E-11
COG4925,[NoAnn],S,37,6,9.55091E-11
COG2185,Methylmalonyl-coA mutase,I,57,6,9.55091E-11
NOG42710,[NoAnn],S,84,6,9.55091E-11
NOG39612,Cytidylate kinase,S,60,6,9.55088E-11
COG2115,Xylose Isomerase,G,50,6,9.55088E-11
NOG108071,[NoAnn],S,22,6,9.55087E-11
NOG41367,"4Fe-4S ferredoxin, iron-sulfur binding",C,48,6,9.55086E-11
COG1884,methylmalonyl-coA mutase,I,62,6,9.55086E-11
NOG79115,50S ribosomal protein L35,J,72,6,9.55076E-11
NOG12036,[NoAnn],S,15,6,9.55076E-11
NOG20753,Membrane,S,54,6,9.55075E-11
NOG212626,Phosphotransferase enzyme family,R,65,6,9.55075E-11
COG1469,"Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)",S,34,6,9.55074E-11
NOG108480,[NoAnn],S,18,6,9.55069E-11
NOG14719,Histidine kinase,T,30,6,9.55062E-11
NOG69459,[NoAnn],S,48,6,9.55061E-11
NOG06950,[NoAnn],S,38,6,9.55058E-11
NOG66310,[NoAnn],S,33,6,9.55057E-11
NOG80165,[NoAnn],S,40,6,9.55051E-11
NOG64656,[NoAnn],S,70,6,9.55051E-11
NOG17204,[NoAnn],S,52,6,9.55046E-11
NOG101032,[NoAnn],S,16,6,9.55044E-11
NOG03600,[NoAnn],S,37,6,9.55042E-11
NOG39765,Ser Thr phosphatase family protein,R,55,6,9.55042E-11
NOG217246,Major capsid protein,R,34,6,9.5504E-11
NOG78890,pts system,G,16,6,9.5504E-11
NOG48809,adenylate cyclase,S,47,6,9.55038E-11
COG2069,"Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex (By similarity)",C,41,8,9.51395E-11
NOG01560,"leucyl aminopeptidase, aminopeptidase T",S,78,7,6.72597E-11
NOG50676,Ubiquitin family,O,65,8,6.42247E-11
COG1613,Sulfate ABC transporter periplasmic sulfate-binding protein,P,55,8,6.41362E-11
NOG02765,atp gtp binding protein,S,29,7,6.20098E-11
NOG64505,[NoAnn],S,58,7,6.10747E-11
NOG51558,DNA-binding helix-turn-helix protein,K,50,8,4.62374E-11
COG3052,Covalent carrier of the coenzyme of citrate lyase (By similarity),C,56,7,4.50826E-11
NOG159318,[NoAnn],S,45,8,4.31448E-11
COG3041,"Addiction module toxin, RelE StbE family",S,173,16,4.21795E-11
COG1972,)-nucleoside,F,20,7,4.04607E-11
NOG214040,[NoAnn],S,34,7,3.10212E-11
NOG79241,[NoAnn],S,62,7,2.7435E-11
COG3275,Histidine kinase,T,83,9,2.569E-11
COG3557,UPF0374 protein,J,61,8,2.25092E-11
NOG14417,na solute symporter,R,30,7,2.07414E-11
NOG01306,Uncharacterized conserved protein (DUF2075),S,88,7,1.97896E-11
NOG39678,site-specific tyrosine recombinase XerS,L,25,7,1.79562E-11
NOG95617,[NoAnn],S,30,7,1.72899E-11
NOG52526,"toxin-antitoxin system, toxin component, PIN family",R,56,7,1.65782E-11
COG3786,ErfK ybiS ycfS ynhG family protein,S,52,7,1.57463E-11
NOG66578,[NoAnn],S,30,7,1.50494E-11
NOG80467,"Anti-sigma-28 factor, FlgM",S,30,7,1.40492E-11
COG4659,Electron transport complex,C,101,7,1.35737E-11
NOG53074,conserved domain protein,S,38,7,1.22705E-11
COG2936,"hydrolase, CocE NonD family protein",R,25,7,1.20172E-11
NOG49779,Uncharacterised protein family (UPF0236),S,52,7,1.19347E-11
NOG97717,Sigma-70 region 2 ,S,27,8,1.09259E-11
NOG212290,Pfam:Transposase_11,L,37,7,1.07442E-11
NOG85355,Transcriptional regulator,K,23,7,9.76677E-12
NOG65815,[NoAnn],S,32,7,9.55352E-12
COG1182,"Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)",I,54,9,8.92739E-12
NOG67849,[NoAnn],S,34,7,8.78542E-12
NOG80398,Protein of unknown function (DUF1292),S,47,7,8.40958E-12
NOG74995,[NoAnn],S,49,7,8.1443E-12
COG2602,Beta-lactamase,V,32,7,8.01724E-12
NOG15001,NAD(P)H-dependent FMN reductase,R,40,7,7.83996E-12
NOG62205,acetyltransferase,R,83,7,7.76615E-12
NOG81019,phage protein,S,30,7,7.61473E-12
NOG149677,gCN5-related N-acetyltransferase,R,44,7,7.57201E-12
NOG53728,repeat protein,S,87,7,7.56342E-12
NOG55539,[NoAnn],S,55,7,7.44221E-12
NOG62673,"preprotein translocase, yajc subunit",U,57,7,7.42629E-12
NOG102440,"spore cortex biosynthesis protein, YabQ",S,38,7,7.37402E-12
NOG82778,nucleic acid binding protein,R,53,7,7.26688E-12
NOG101791,[NoAnn],S,23,7,7.18445E-12
NOG10930,Excinuclease ABC subunit C,S,59,7,7.05336E-12
NOG66128,restriction endonuclease,V,43,7,7.03907E-12
COG3969,phosphoadenosine phosphosulfate reductase,R,63,7,7.02161E-12
COG4289,conserved protein,S,37,8,6.8577E-12
NOG17751,AIPR protein,S,40,7,6.85218E-12
NOG42821,[NoAnn],S,30,7,6.80969E-12
COG1788,Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity),I,60,7,6.67883E-12
NOG80745,[NoAnn],S,68,7,6.62237E-12
NOG93316,[NoAnn],S,120,7,6.59469E-12
NOG43372,transcriptional regulators,K,39,7,6.5746E-12
NOG83208,Membrane,S,31,7,6.45593E-12
NOG14156,phage minor capsid protein,S,58,9,6.41979E-12
NOG102861,RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity),J,52,7,6.40581E-12
NOG53436,Pfam:DUF1393,S,33,7,6.35275E-12
NOG81048,RNA Polymerase,K,57,7,6.33627E-12
NOG29019,Protein of unknown function (DUF3644) ,S,41,7,6.2478E-12
COG4813,Trehalose utilization protein,G,63,7,6.22853E-12
NOG54591,Ham1 family,S,21,7,6.21908E-12
NOG69613,[NoAnn],S,94,7,6.1905E-12
NOG14279,[NoAnn],S,60,7,6.18997E-12
NOG218545,TraX protein,S,19,7,6.1807E-12
NOG85429,Protein of unknown function (DUF1700),S,40,7,6.17703E-12
NOG107872,[NoAnn],S,49,7,6.08234E-12
COG5505,membrane,S,55,7,6.0673E-12
NOG212422,[NoAnn],S,50,7,6.06259E-12
COG1514,2'-5' rna ligase,J,41,7,6.03823E-12
NOG230612,"Uncharacterised ACR, COG2135",S,7,7,6.02605E-12
COG1778,3-deoxy-d-manno-octulosonate 8-phosphate phosphatase,R,55,7,6.00918E-12
NOG214601,Phosphoadenosine phosphosulfate reductase family,S,37,7,5.97597E-12
NOG37378,[NoAnn],S,97,7,5.96755E-12
NOG91466,"transposase, IS3 IS911 family protein",L,30,9,5.96737E-12
COG2060,"One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)",P,45,7,5.94293E-12
NOG63621,ggdef domain,T,19,7,5.93672E-12
COG1684,Role in flagellar biosynthesis (By similarity),N,54,7,5.92498E-12
NOG14761,Aminoglycoside 6-adenylyltransferase,S,39,7,5.90286E-12
COG2173,dipeptidase,M,46,7,5.88578E-12
NOG213869,Membrane,S,53,7,5.8819E-12
NOG86689,[NoAnn],S,21,7,5.83421E-12
NOG66614,tetratricopeptide repeat protein,S,39,7,5.82627E-12
NOG54362,Transcriptional regulator,K,56,7,5.80502E-12
NOG62665,NHL repeat containing protein,S,16,7,5.80418E-12
NOG15732,SCP-2 sterol transfer family,S,38,7,5.80391E-12
NOG16429,[NoAnn],S,51,7,5.80134E-12
NOG49567,Metal Dependent Phosphohydrolase,T,40,7,5.78798E-12
NOG215024,Glycosyl Transferase,M,42,7,5.67417E-12
NOG30044,[NoAnn],S,55,7,5.66325E-12
COG3039,Transposase,L,75,7,5.65962E-12
COG0643,CheA signal transduction histidine kinase,T,77,7,5.65828E-12
NOG53910,[NoAnn],S,35,7,5.64724E-12
NOG39936,methyltransferase,R,32,7,5.63968E-12
COG1868,"FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)",N,54,7,5.61621E-12
NOG212316,Predicted membrane protein (DUF2207),S,55,7,5.61113E-12
NOG212178,Phage tail sheath protein,R,37,7,5.59543E-12
NOG10244,[NoAnn],S,45,7,5.58598E-12
NOG62666,prophage pi2 protein 38,S,66,7,5.58088E-12
NOG01798,Beta-lactamase,V,56,7,5.57691E-12
NOG165808,[NoAnn],S,33,7,5.54471E-12
NOG79413,Flagellar operon protein,N,37,7,5.52655E-12
NOG12508,[NoAnn],S,48,7,5.5251E-12
NOG194163,[NoAnn],S,26,7,5.48751E-12
NOG31274,"XkdM protein, phage-like element PBSX",S,55,7,5.48595E-12
COG1297,oligo-peptide transporter,S,83,7,5.47826E-12
COG1440,PTS System,G,60,7,5.4402E-12
NOG174404,[NoAnn],S,21,7,5.42707E-12
COG0407,Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity),H,44,7,5.35677E-12
NOG52342,Transcriptional regulator,K,44,7,5.35121E-12
NOG13676,[NoAnn],S,53,7,5.34634E-12
NOG101626,integral membrane protein,S,70,7,5.34337E-12
COG0717,Deoxycytidine triphosphate deaminase,F,48,7,5.29911E-12
NOG213803,[NoAnn],S,27,7,5.28719E-12
COG3404,Methenyltetrahydrofolate cyclohydrolase,E,115,9,5.225E-12
NOG38199,[NoAnn],S,44,7,5.20074E-12
NOG74574,DNA-binding helix-turn-helix protein,S,21,7,5.19587E-12
NOG82923,[NoAnn],S,109,7,5.16984E-12
NOG16267,abc transporter permease protein,V,87,7,5.09961E-12
COG2859,Periplasmic Protein,S,30,7,5.0926E-12
COG1915,LOR SDH bifunctional protein conserved domain protein,S,49,7,5.00199E-12
COG2304,"von Willebrand factor, type A",R,173,8,4.9689E-12
COG3173,Aminoglycoside phosphotransferase,R,45,7,4.91872E-12
COG4466,Veg protein,S,80,7,4.90002E-12
NOG81852,[NoAnn],S,93,7,4.86353E-12
NOG66819,s-layer domain protein,S,12,7,4.8593E-12
COG0699,Dynamin family,R,59,7,4.83011E-12
NOG21580,oxidoreductase Domain protein,R,20,7,4.82095E-12
NOG15891,restriction endonuclease,V,45,7,4.81436E-12
NOG49707,flp pilus assembly protein,U,60,7,4.78139E-12
COG1715,restriction,V,81,7,4.74758E-12
NOG14571,"cell wall assembly cell proliferation coordinating protein, KNR4-like protein",S,40,7,4.71048E-12
COG2986,histidine ammonia-lyase,E,60,7,4.60744E-12
COG2875,precorrin-4 C(11)-methyltransferase,H,78,7,4.5794E-12
NOG78199,phage protein,S,48,7,4.56667E-12
NOG02713,sialic acid-specific 9-O-acetylesterase,S,42,7,4.56532E-12
COG4145,Sodium pantothenate symporter,H,46,7,4.49196E-12
NOG16442,"transcriptional regulator, araC family",K,27,7,4.43187E-12
COG3680,[NoAnn],S,25,7,4.41178E-12
COG0689,Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity),J,50,7,4.4043E-12
NOG102557,"transcriptional regulator, AraC family",K,52,7,4.38689E-12
COG1113,amino acid,E,27,7,4.3844E-12
NOG35881,[NoAnn],M,33,7,4.3778E-12
COG2717,Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity),P,22,7,4.36927E-12
NOG83786,[NoAnn],S,26,7,4.36143E-12
NOG32660,Transposase,L,51,7,4.35597E-12
NOG02828,DNA (cytosine-5-)-methyltransferase 3,L,25,7,4.34838E-12
NOG91532,LytTR,T,30,7,4.28918E-12
NOG03930,Nad-dependent epimerase dehydratase,R,26,7,4.28001E-12
NOG54418,thioesterase Superfamily protein,R,58,7,4.27822E-12
NOG217852,HTH_XRE,K,34,7,4.25514E-12
COG3933,transcriptional,K,60,7,4.25045E-12
COG1221,transcriptional,K,61,7,4.25045E-12
COG3254,Involved in the anomeric conversion of L-rhamnose (By similarity),S,47,7,4.24899E-12
NOG80141,Helix-turn-helix,S,82,7,4.24335E-12
NOG76919,[NoAnn],S,35,7,4.23894E-12
COG3862,protein with conserved CXXC pairs,S,120,8,4.23712E-12
NOG58289,"Transcriptional regulator, TetR family",K,53,7,4.22672E-12
NOG01436,Protein of unknown function (DUF2397),S,44,7,4.22297E-12
NOG104096,Protein of unknown function (DUF3343),S,45,7,4.21622E-12
NOG110479,[NoAnn],S,27,7,4.207E-12
NOG17860,Flavin_Reduct,S,21,7,4.19756E-12
NOG53434,p-loop ATPase,R,32,7,4.19502E-12
COG5362,phage protein,R,63,7,4.19366E-12
NOG67470,[NoAnn],S,30,7,4.19345E-12
COG4477,modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity),D,54,7,4.18804E-12
NOG104858,Domain of unknown function (DUF1934),S,41,7,4.18347E-12
COG5324,TRNA ligase,S,50,7,4.17643E-12
COG2120,lmbE family,S,27,7,4.17303E-12
NOG08665,Minor capsid protein,S,20,7,4.17258E-12
NOG13403,bacteriophage protein,S,34,7,4.16911E-12
NOG79508,transcriptional regulator AsnC family,K,52,7,4.16859E-12
NOG103151,PemK-like protein,S,48,7,4.16689E-12
NOG77232,[NoAnn],S,41,7,4.16646E-12
COG1524,type i phosphodiesterase nucleotide pyrophosphatase,R,57,7,4.1637E-12
NOG21860,[NoAnn],S,43,7,4.16073E-12
NOG75874,[NoAnn],S,45,7,4.15113E-12
NOG66015,LysR family transcriptional regulator,K,24,7,4.15113E-12
NOG05714,Polysaccharide biosynthesis protein,S,51,7,4.15057E-12
NOG73077,N-acetylmuramoyl-L-alanine amidase,S,64,7,4.14802E-12
NOG84173,[NoAnn],S,28,7,4.14707E-12
NOG01514,Phage minor structural protein,S,31,7,4.14416E-12
NOG50521,C_GCAxxG_C_C family,S,28,7,4.14327E-12
NOG01921,Nadph-dependent fmn reductase,R,31,7,4.14309E-12
COG1252,Nadh dehydrogenase,C,19,7,4.14248E-12
NOG14626,Malate lactate,S,31,7,4.14198E-12
NOG30740,[NoAnn],S,26,7,4.14128E-12
NOG23558,[NoAnn],S,64,7,4.13959E-12
NOG07674,Transposase (IS4 family,L,26,7,4.13953E-12
NOG08221,Phage cell wall hydrolase,R,77,7,4.13903E-12
COG0434,photosystem i assembly btpa,R,37,7,4.1384E-12
NOG42005,Transcriptional regulator,K,46,7,4.13824E-12
COG1075,Triacylglycerol lipase,R,61,7,4.13813E-12
COG1886,Flagellar motor switch protein,N,78,7,4.13761E-12
NOG212639,[NoAnn],S,23,7,4.13729E-12
NOG31181,[NoAnn],S,35,7,4.13727E-12
NOG36154,methyltransferase,R,77,7,4.13709E-12
NOG33939,[NoAnn],S,45,7,4.13704E-12
NOG60266,Capsular polysaccharide synthesis protein,M,32,7,4.13703E-12
NOG04968,solute-binding protein,G,55,7,4.13675E-12
NOG101390,s4 domain protein,S,83,7,4.13675E-12
NOG212982,Transcriptional regulator,K,49,7,4.13673E-12
NOG08135,VWA-like domain (DUF2201),S,87,7,4.13666E-12
NOG215353,Phage minor capsid protein 2,S,31,7,4.13659E-12
NOG32152,Ferredoxin,C,37,7,4.1365E-12
COG4908,protein containing a NRPS condensation (Elongation),S,16,7,4.13639E-12
NOG64951,rna polymerase,K,29,7,4.13636E-12
COG3142,copper homeostasis protein cutc,P,70,7,4.1363E-12
NOG48485,gCN5-related N-acetyltransferase,R,54,7,4.13629E-12
COG5577,Spore Coat Protein,M,70,8,3.40052E-12
NOG67778,membrane,S,51,8,2.97807E-12
NOG212330,Histidine kinase,T,43,8,2.37781E-12
NOG62604,[NoAnn],S,28,8,1.57308E-12
NOG14492,Transcriptional regulator,K,50,8,1.47158E-12
COG2368,4-hydroxyphenylacetate,Q,50,8,1.46382E-12
NOG64105,[NoAnn],S,18,8,1.36301E-12
NOG105057,SirA-like domain-containing protein,S,19,8,1.13345E-12
NOG64184,methyltransferase,S,50,8,1.11531E-12
COG2946,Replication initiation factor,L,66,10,1.04193E-12
NOG213851,glycosyl transferase family,M,32,8,1.03998E-12
NOG47774,Protein of unknown function DUF126,S,61,8,9.51835E-13
NOG41075,nucleoside hydrolase,R,80,8,9.48727E-13
COG2963,transposase,L,124,8,9.22572E-13
NOG76051,[NoAnn],S,50,8,8.80693E-13
COG1923,"RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)",T,88,8,8.80027E-13
COG2962,rard protein,R,59,8,8.49845E-13
NOG05081,[NoAnn],S,51,8,7.99967E-13
NOG00130,Binding-protein-dependent transport systems inner membrane component,P,61,8,7.30998E-13
NOG07870,Type II restriction,V,59,9,7.22956E-13
NOG80138,[NoAnn],S,65,8,6.26853E-13
NOG57248,HTH_XRE,K,78,11,6.21412E-13
NOG30109,radical SAM domain protein,R,33,8,5.87925E-13
NOG70486,[NoAnn],S,27,8,5.86116E-13
NOG115608,RNA polymerase sigma factor sigma-70 family,K,50,8,5.81878E-13
NOG215059,transposase,L,88,8,5.44855E-13
NOG81431,[NoAnn],S,21,9,5.42483E-13
NOG212379,Histidine kinase,T,66,11,5.26481E-13
NOG15560,[NoAnn],S,18,8,5.18217E-13
NOG34517,domain) protein,S,141,15,5.10605E-13
NOG27630,"sigma-70, region 4",S,30,8,5.1051E-13
NOG61951,Diguanylate cyclase,T,76,9,4.9444E-13
NOG09701,Transglutaminase-like,S,60,8,4.86927E-13
NOG221771,Phage minor capsid protein 2,S,30,8,4.31903E-13
NOG178254,Integrase core domain,S,63,8,4.31879E-13
NOG36889,[NoAnn],S,52,9,4.28338E-13
NOG81025,"H -ATPase, subunit H",S,87,8,4.13439E-13
COG3497,tail sheath protein,R,64,8,4.0669E-13
NOG230306,HTH_XRE,S,41,8,3.89656E-13
NOG35691,[NoAnn],S,31,8,3.89435E-13
COG2868,(ribosomal) protein,J,96,8,3.84753E-13
COG1220,this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity),O,65,8,3.83584E-13
COG1871,"Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)",N,38,8,3.81413E-13
NOG02699,binding-protein-dependent transport systems inner membrane Component,P,80,8,3.77833E-13
NOG81485,[NoAnn],S,46,8,3.70043E-13
NOG191032,[NoAnn],S,77,8,3.50781E-13
NOG213966,Spore germination,R,57,8,3.3324E-13
COG0851,Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity),D,77,8,3.31839E-13
NOG108894,Minor head protein,S,21,8,3.29701E-13
NOG75083,[NoAnn],S,64,8,3.19649E-13
NOG03022,Mate efflux family protein,V,66,8,3.18193E-13
NOG66610,Transcriptional regulator,K,45,8,3.1566E-13
NOG35363,[NoAnn],S,26,8,3.09956E-13
NOG104694,[NoAnn],S,53,8,3.09635E-13
NOG49048,Sulfatase,R,41,8,3.02212E-13
NOG00257,Methyl-accepting chemotaxis,S,34,8,2.99283E-13
NOG216335,Membrane,S,34,9,2.97585E-13
COG3401,fibronectin type III domain protein,S,52,8,2.9335E-13
COG1921,Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity),E,26,8,2.92322E-13
NOG55752,Recombinase,S,39,11,2.91709E-13
NOG06283,Histidine kinase,T,29,8,2.89882E-13
NOG49359,[NoAnn],S,30,8,2.8302E-13
NOG90953,Uncharacterised protein family (UPF0104),S,30,8,2.81979E-13
NOG61959,Ribonuclease,S,73,8,2.81355E-13
NOG143400,[NoAnn],S,27,8,2.796E-13
COG4692,BNR Asp-box repeat protein,G,47,8,2.70515E-13
NOG111826,[NoAnn],S,21,8,2.69333E-13
NOG83669,"acetyltransferase, (GNAT) family",R,56,8,2.68166E-13
NOG21705,[NoAnn],S,17,8,2.63434E-13
NOG49288,"Peptidase M15B and M15C DD-carboxypeptidase VanY, endolysin",M,44,8,2.63373E-13
COG1314,Preprotein translocase subunit SecG,U,35,8,2.63234E-13
NOG13321,"phage major tail protein, phi13 family",R,73,8,2.62772E-13
NOG51169,Phage-related protein,S,64,8,2.61491E-13
NOG01899,glycosyl transferase group 1,M,21,8,2.60053E-13
NOG216909,HTH_XRE,S,51,8,2.57592E-13
NOG103293,Protein of unknwon function (DUF3310),S,46,8,2.57116E-13
NOG103597,[NoAnn],S,45,8,2.56342E-13
COG1748,saccharopine dehydrogenase,E,83,8,2.56269E-13
COG4637,SMC domain protein,S,29,9,2.5525E-13
NOG216552,[NoAnn],S,72,8,2.54267E-13
NOG28450,[NoAnn],S,47,8,2.53858E-13
COG1377,flagellar biosynthetic protein flhB,N,74,8,2.52164E-13
NOG12926,(ABC) transporter,V,84,8,2.51549E-13
NOG95851,HEPN domain,S,33,8,2.5032E-13
NOG50314,Pfam:DUF477,S,51,8,2.49058E-13
COG4990,[NoAnn],S,70,8,2.47184E-13
NOG96419,[NoAnn],S,55,8,2.46431E-13
NOG84549,[NoAnn],S,59,8,2.46419E-13
NOG216228,"Transcriptional regulator, TetR family",K,58,8,2.44948E-13
NOG62004,GDSL-like protein,S,57,8,2.41935E-13
COG1044,"Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)",M,43,8,2.40941E-13
COG1895,Hepn domain protein,S,53,8,2.38058E-13
NOG30621,group 1 family,M,42,8,2.37606E-13
NOG219481,"transcriptional regulator, xre family",K,48,8,2.37228E-13
NOG98386,[NoAnn],R,33,8,2.34974E-13
NOG05533,Transcriptional regulator,K,21,8,2.32903E-13
NOG57239,Predicted metal-binding protein (DUF2284),S,59,8,2.31546E-13
NOG97883,[NoAnn],S,23,8,2.31256E-13
NOG00640,Glycosyl transferase group 1,M,67,8,2.30862E-13
NOG79192,[NoAnn],S,43,8,2.30036E-13
NOG78792,[NoAnn],S,60,8,2.2868E-13
NOG05067,Integrase,L,59,8,2.27314E-13
NOG02301,Short-chain dehydrogenase reductase Sdr,R,42,8,2.25139E-13
NOG38164,Flavodoxin-like fold,R,35,8,2.24617E-13
NOG87431,Domain of unknown function DUF87,R,44,8,2.24423E-13
COG3856,small basic protein,S,48,8,2.23444E-13
NOG106195,DNA binding domaincontaining protein,R,81,8,2.21122E-13
COG3697,holo-ACP synthase CitX,H,38,8,2.17498E-13
COG0432,Secondary thiamine-phosphate synthase enzyme,S,61,8,2.15761E-13
NOG83305,[NoAnn],S,63,8,2.15317E-13
COG2310,tellurium resistance protein,T,109,8,2.15039E-13
NOG64842,flavodoxin,S,54,8,2.14771E-13
NOG95312,[NoAnn],S,40,8,2.14631E-13
COG3611,replication initiation and membrane attachment,L,60,8,2.14129E-13
NOG215007,macrophage migration inhibitory factor,S,72,10,2.1198E-13
NOG109241,[NoAnn],S,63,8,2.10417E-13
COG5164,Transcription elongation factor,K,29,8,2.07275E-13
NOG107218,[NoAnn],S,65,8,2.05792E-13
COG4859,Protein of unknown function (DUF2185),S,65,8,2.0543E-13
NOG101759,Ferrous iron transport protein A,P,35,11,2.02564E-13
NOG32386,Dehydrogenase,R,42,8,2.00875E-13
COG3007,reductase (By,S,21,8,2.00672E-13
NOG01276,fg-gap repeat protein,S,23,8,2.00118E-13
NOG212560,Glycosyl hydrolase family 43,G,78,8,1.99899E-13
COG0636,"F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)",C,136,10,1.98752E-13
NOG219775,VRR-NUC domain protein,S,39,8,1.98042E-13
COG5495,"NADP oxidoreductase, coenzyme f420-dependent",S,42,8,1.97532E-13
NOG01801,membrane,S,146,9,1.96816E-13
COG1607,thioesterase Superfamily protein,I,73,8,1.96697E-13
NOG83659,Subunit f,C,51,8,1.95085E-13
NOG80482,tail fiber protein,S,65,8,1.9432E-13
NOG214523,"nucleotidyltransferase substrate binding protein, HI0074 family",R,50,8,1.92649E-13
COG0529,Catalyzes the synthesis of activated sulfate (By similarity),P,25,8,1.92637E-13
COG2828,AcnD-accessory protein PrpF,S,40,8,1.9198E-13
COG1724,ycfa family,N,28,8,1.90829E-13
NOG19775,[NoAnn],S,38,8,1.8971E-13
NOG50145,Haloacid dehalogenase family hydrolase domain containing protein,R,50,8,1.89361E-13
NOG25277,"germination protein, ger(x)c family",S,59,8,1.87738E-13
COG0114,fumarate hydratase class II,C,82,8,1.87584E-13
NOG61776,Erf family,S,61,8,1.87541E-13
NOG82382,s-layer domain-containing protein,S,61,8,1.87012E-13
NOG101576,Tripartite ATP-independent periplasmic transporter dctq component,P,43,8,1.86345E-13
NOG197255,Phage integrase family,S,28,8,1.86105E-13
NOG33288,"Transcriptional regulator, luxr family",K,30,8,1.85342E-13
NOG222370,Domain of unknown function (DUF1837),S,31,8,1.8534E-13
NOG40626,lipolytic protein G-D-S-L family,S,44,8,1.84947E-13
COG0266,"Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)",L,67,8,1.84748E-13
NOG31222,[NoAnn],S,51,8,1.84747E-13
COG3598,RecA-family ATPase,L,51,8,1.84656E-13
NOG72524,"ParB domain protein, nuclease",K,24,8,1.8461E-13
COG1605,Chorismate mutase,E,55,8,1.82827E-13
NOG150785,[NoAnn],S,83,8,1.81912E-13
NOG00220,"transcriptional regulator, lysr family",K,53,8,1.81588E-13
NOG221684,[NoAnn],S,45,8,1.81549E-13
COG0155,Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity),C,45,8,1.80834E-13
COG1157,flagellum-specific ATP synthase,N,63,8,1.80662E-13
COG2703,"hemerythrin-like, metal-binding protein",P,56,8,1.80594E-13
NOG210447,Protein of unknown function (DUF1064),S,44,8,1.80388E-13
COG5610,Hydrolase,R,74,8,1.80244E-13
NOG214159,[NoAnn],S,62,8,1.80049E-13
NOG09329,Diguanylate cyclase,T,42,8,1.80029E-13
NOG66523,antar domain protein,T,81,8,1.79929E-13
NOG15016,spore coat protein CotH,S,64,8,1.79853E-13
COG0510,choline kinase,M,85,8,1.79826E-13
NOG76158,[NoAnn],S,34,8,1.79784E-13
NOG22447,[NoAnn],S,78,8,1.79753E-13
NOG110447,Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide,S,90,8,1.79737E-13
COG3833,ABC transporter (permease),P,96,8,1.79719E-13
NOG00331,"Glycoside hydrolase, family 9",G,47,8,1.79697E-13
NOG103794,"sporulation protein, YlmC YmxH family",S,67,8,1.79662E-13
NOG00673,Binding-protein-dependent transport systems inner membrane component,G,54,8,1.7962E-13
NOG87880,[NoAnn],S,45,8,1.79527E-13
NOG56902,Formate nitrite transporter,P,38,8,1.79521E-13
NOG18315,Restriction endonuclease BpuJI - N terminal,S,43,8,1.79501E-13
COG3717,"Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)",G,57,8,1.7949E-13
NOG84510,[NoAnn],S,44,8,1.79424E-13
COG2931,Hemolysin-type calcium-binding,Q,59,8,1.79417E-13
NOG104176,Cobalt transport protein,P,26,8,1.79379E-13
NOG82446,domain protein,R,26,8,1.79321E-13
COG3340,peptidase',E,53,8,1.79247E-13
NOG82611,[NoAnn],S,44,8,1.79235E-13
NOG02109,"Extracellular solute-binding protein, family 5",R,37,8,1.79199E-13
NOG80763,Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity),K,57,8,1.79193E-13
NOG03185,domain protein,S,48,8,1.79191E-13
NOG44849,ggdef family,T,19,8,1.79187E-13
NOG60868,[NoAnn],S,56,8,1.79178E-13
COG3836,Aldolase,G,108,8,1.79178E-13
COG1148,"4Fe-4S Ferredoxin, iron-sulfur binding domain protein",C,70,8,1.79175E-13
NOG48652,[NoAnn],S,66,8,1.79166E-13
NOG80197,[NoAnn],S,63,8,1.79158E-13
COG2367,Beta-lactamase,V,83,8,1.79152E-13
NOG216112,Listeria-Bacteroides repeat domain (List_Bact_rpt),S,72,8,1.79149E-13
NOG35145,[NoAnn],S,35,8,1.79149E-13
NOG58014,host cell surface-exposed lipoprotein,S,29,8,1.79146E-13
COG2604,Motility accessory factor,S,87,8,1.79144E-13
NOG06006,Uncharacterised protein family (UPF0236),S,77,9,1.60423E-13
COG1708,DNA polymerase beta domain protein region,R,71,12,1.48246E-13
NOG26491,"transposase (IS4,)",L,88,12,1.41166E-13
NOG29941,[NoAnn],S,66,10,1.04495E-13
NOG53700,[NoAnn],S,78,10,7.6227E-14
NOG90056,[NoAnn],S,48,9,5.88517E-14
COG3304,membrAne,S,75,9,5.49179E-14
COG2271,transporter,G,67,9,5.27915E-14
NOG12749,binding-protein-dependent transport systems inner membrane component,G,52,9,5.16979E-14
NOG27585,Conserved repeat,S,71,9,4.85251E-14
NOG194280,integrase family,S,56,9,4.7555E-14
NOG214432,[NoAnn],S,78,10,4.35263E-14
NOG01662,Major Facilitator,G,62,9,3.36496E-14
NOG11336,helicase,L,45,10,3.31884E-14
COG1586,"Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)",E,100,9,3.10906E-14
COG2103,"Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate",R,59,9,2.99201E-14
NOG73581,"regulator, lysr family",K,34,9,2.9574E-14
NOG62662,Transposase is3 is911 family protein,L,40,9,2.88888E-14
COG2026,"Addiction module toxin, RelE StbE family",D,99,10,2.81788E-14
COG4938,[NoAnn],S,36,9,2.41969E-14
NOG85973,phage protein,S,55,9,2.36394E-14
NOG212444,[NoAnn],S,37,9,2.28272E-14
COG3077,"Addiction module antitoxin, RelB DinJ family",L,193,18,2.17263E-14
NOG46097,integrase family,L,94,10,2.13144E-14
NOG82635,mobA MobL family protein,S,24,9,2.08748E-14
COG3878,Domain of unknown function (DUF1963),S,42,9,1.975E-14
COG4399,UPF0754 membrane protein,S,37,9,1.82418E-14
COG0288,carbonic anhydrase,P,52,9,1.80994E-14
NOG67696,Carbon-nitrogen hydrolase,R,26,9,1.80263E-14
NOG64029,[NoAnn],S,88,9,1.77603E-14
NOG106360,[NoAnn],S,55,9,1.72024E-14
NOG109082,[NoAnn],S,45,9,1.66669E-14
COG5405,Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity),O,76,9,1.66133E-14
NOG11250,"Type III restriction enzyme, res subunit",V,45,9,1.63243E-14
COG1538,Membrane,M,58,9,1.63203E-14
COG2513,methylisocitrate lyase,G,60,9,1.57554E-14
NOG04041,Nad-dependent epimerase dehydratase,R,50,9,1.57514E-14
NOG101678,domain protein,S,50,10,1.51992E-14
NOG63965,Membrane,S,43,9,1.50366E-14
NOG37034,[NoAnn],S,62,9,1.4968E-14
NOG213292,[NoAnn],S,76,9,1.48886E-14
NOG74567,Protein of unknown function (DUF2812),S,24,9,1.4789E-14
NOG217530,Pfam:PhdYeFM,S,34,9,1.36922E-14
NOG109226,"SPFH domain, Band 7 family protein",S,68,9,1.3609E-14
NOG50986,Conserved hypothetical protein (DUF2461),S,93,9,1.3329E-14
COG3694,ABC transporter (permease),R,72,9,1.32921E-14
COG1142,4Fe-4S Ferredoxin iron-sulfur binding domain protein,C,76,10,1.30284E-14
COG1527,"ATP synthase, subunit",C,102,9,1.29249E-14
COG4775,"Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane",M,59,9,1.2715E-14
NOG01330,Meningioma expressed antigen 5 (Hyaluronidase),S,28,9,1.27123E-14
NOG45067,Xylose isomerase domain protein TIM barrel,G,46,9,1.23595E-14
NOG104721,site-specific recombinase,L,56,9,1.23119E-14
NOG13604,Abc-2 type transporter,V,58,9,1.22864E-14
NOG215074,[NoAnn],S,45,9,1.22795E-14
NOG101770,YopX protein,S,66,10,1.2205E-14
NOG50305,[NoAnn],S,81,9,1.20116E-14
COG1647,carboxylesterase (ec 3.1.1.1),R,71,9,1.19533E-14
NOG00869,fad dependent oxidoreductase,R,89,9,1.19338E-14
NOG135064,Helix-turn-helix,S,37,9,1.1639E-14
NOG31114,phage major capsid protein (HK97 family),R,42,9,1.15093E-14
NOG36045,[NoAnn],S,71,9,1.14014E-14
NOG00425,endonuclease exonuclease phosphatase,S,125,9,1.13347E-14
NOG34318,Abc-2 type transporter,R,68,9,1.11751E-14
COG4997,[NoAnn],S,83,9,1.1172E-14
NOG47807,Transposase,L,50,9,1.1133E-14
NOG108578,[NoAnn],S,41,9,1.10327E-14
COG2094,3-methyladenine DNA glycosylase,L,79,9,1.10225E-14
COG4555,(ABC) transporter,C,53,9,1.09849E-14
NOG01357,Periplasmic binding protein LacI transcriptional regulator,G,47,9,1.09789E-14
NOG05001,Flp pilus assembly protein CpaB,U,88,9,1.0885E-14
NOG106576,[NoAnn],S,45,9,1.07408E-14
NOG62784,Membrane,S,61,9,1.07103E-14
NOG09169,PTS system,G,34,9,1.06006E-14
NOG21285,transposase,L,39,9,1.05731E-14
NOG84867,[NoAnn],S,60,9,1.05731E-14
NOG03005,Transposase (IS4 family) protein,L,75,9,1.05569E-14
NOG38347,[NoAnn],S,38,9,1.04946E-14
NOG32362,(ABC) transporter,E,33,9,1.03203E-14
NOG110837,heavy metal-associated domain protein,S,62,9,1.01802E-14
COG4587,(ABC) transporter,R,77,9,1.01163E-14
NOG51153,Domain-Containing protein,S,86,9,1.00991E-14
NOG63915,Uroporphyrinogen decarboxylase (URO-D),S,63,9,1.00728E-14
COG5484,"terminase, small subunit",S,63,9,9.88272E-15
NOG20038,prophage protein,S,35,9,9.8689E-15
NOG23224,[NoAnn],S,32,9,9.78766E-15
COG2608,heavy metal transport detoxification protein,P,121,13,9.76786E-15
COG5658,Membrane,S,57,9,9.74253E-15
COG2851,Citrate transporter,C,63,9,9.70589E-15
NOG116708,[NoAnn],S,51,9,9.67157E-15
NOG89777,[NoAnn],S,33,9,9.65176E-15
NOG83790,response regulator receiver protein,S,59,9,9.50267E-15
COG1816,Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity),F,77,9,9.48981E-15
COG3443,"ABC superfamily ATP binding cassette transporter, binding protein",R,29,9,9.41696E-15
NOG38987,"Transcriptional regulator, TetR family",K,92,9,9.3827E-15
NOG188701,cyclic nucleotide-binding domain protein,T,54,9,9.32199E-15
COG2119,transmembrane protein 165,S,44,9,9.30425E-15
NOG103681,4Fe-4S ferredoxin iron-sulfur binding domain protein,C,59,9,9.26098E-15
NOG73687,"Addiction module toxin, RelE StbE family",S,95,9,9.25787E-15
NOG80274,UPF0342 protein,S,47,9,9.22944E-15
COG0308,aminopeptidase,E,65,9,9.08156E-15
NOG09807,phage capsid family,R,57,9,8.95763E-15
NOG92702,ORF6N domain,S,52,9,8.88772E-15
NOG12248,"von Willebrand factor, type A",R,16,9,8.86142E-15
NOG212226,[NoAnn],S,39,9,8.86081E-15
COG1447,pts system,G,65,9,8.78853E-15
NOG63592,Hydrogenase nickel insertion protein HypA,O,54,9,8.69894E-15
NOG78869,Diguanylate cyclase,T,71,9,8.67867E-15
NOG85321,phage protein,S,57,9,8.47176E-15
COG1721,"von Willebrand factor, type A",S,39,9,8.42629E-15
NOG14526,helicase,S,65,9,8.4082E-15
COG4573,that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of,G,30,9,8.35687E-15
COG3957,Phosphoketolase,G,72,12,8.3488E-15
NOG00203,Predicted AAA-ATPase,S,130,12,8.33339E-15
NOG04227,[NoAnn],S,86,9,8.30375E-15
COG1551,Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity),T,32,9,8.26954E-15
COG4487,Uncharacterized protein conserved in bacteria (DUF2130),S,53,9,8.22242E-15
NOG85834,[NoAnn],S,85,9,8.177E-15
NOG216703,HTH_XRE,K,45,9,8.14765E-15
COG0814,Amino acid transporter,E,47,9,8.10925E-15
NOG30653,[NoAnn],S,71,9,8.09623E-15
NOG60220,[NoAnn],S,62,9,8.02507E-15
COG0661,"Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)",R,75,9,8.01198E-15
NOG215761,Protein of unknown function (DUF2493),S,38,9,7.93688E-15
COG3408,Glycogen debranching enzyme,G,68,9,7.93338E-15
COG3947,response regulator receiver and SARP domain protein,T,56,9,7.93227E-15
NOG38878,S-layer homology domain,S,49,9,7.87756E-15
COG1806,"Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)",S,24,9,7.85858E-15
NOG79425,Copper amine oxidase domain protein,S,70,9,7.85475E-15
NOG120480,[NoAnn],S,19,9,7.85339E-15
NOG80024,Protein of unknown function (DUF3298),S,41,9,7.85041E-15
NOG214275,[NoAnn],S,46,9,7.80949E-15
COG3033,tryptophanase EC 4.1.99.1,E,46,9,7.80576E-15
NOG40022,PPIC-type PPIASE domain,S,101,9,7.80568E-15
NOG44365,[NoAnn],S,114,9,7.8024E-15
NOG104431,[NoAnn],S,40,9,7.8005E-15
NOG88665,Pilin isopeptide linkage domain protein,S,44,9,7.79934E-15
COG2313,Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity),Q,91,9,7.79601E-15
COG2733,Membrane,S,42,9,7.79334E-15
NOG52635,Protein of unknown function (DUF2992),S,95,9,7.78212E-15
NOG33155,Transcriptional activator,T,52,9,7.77325E-15
COG1360,Ompa motb domain protein,N,76,9,7.77128E-15
NOG213822,[NoAnn],S,55,9,7.77111E-15
NOG99862,[NoAnn],S,31,9,7.76962E-15
NOG29702,isopropylmalate homocitrate citramalate,Q,51,9,7.76643E-15
COG2201,catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity),T,56,9,7.76557E-15
COG1010,Precorrin-3B C17-methyltransferase,H,71,9,7.76498E-15
NOG65225,Protein of unknown function (DUF2971),S,41,9,7.76496E-15
NOG34415,[NoAnn],S,37,9,7.76468E-15
NOG25316,Outer membrane autotransporter,S,55,9,7.76428E-15
NOG00622,ig domain protein group 2 domain protein,S,22,9,7.76348E-15
NOG180224,Serine Threonine protein kinase,T,23,9,7.76207E-15
NOG61804,[NoAnn],S,64,9,7.76027E-15
NOG105362,[NoAnn],S,42,9,7.76E-15
NOG66236,[NoAnn],S,57,9,7.75997E-15
NOG12856,[NoAnn],S,57,9,7.75957E-15
NOG82668,[NoAnn],S,55,9,7.75931E-15
NOG29031,Transcriptional regulator,K,55,9,7.75916E-15
NOG78944,[NoAnn],S,55,9,7.75909E-15
COG1306,GTP-Binding protein,S,64,9,7.75908E-15
NOG92629,[NoAnn],S,18,9,7.75878E-15
COG3567,"Phage-associated protein, HI1409 family",S,62,9,7.75877E-15
NOG71207,[NoAnn],L,49,10,7.51194E-15
NOG00344,Isoaspartyl dipeptidase,R,66,10,7.42809E-15
COG1691,1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AiR) carboxylase,S,111,10,6.30366E-15
COG5341,Secreted protein,S,79,10,6.12553E-15
COG2954,Adenylate cyclase,S,76,10,5.40087E-15
NOG03089,CRISPR-Associated Protein,L,172,10,5.38301E-15
NOG31814,[NoAnn],S,76,13,5.00191E-15
NOG24108,Protein of unknown function (DUF3298),S,79,12,4.80055E-15
COG1348,"The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)",P,81,10,4.59105E-15
NOG47020,CRISPR-associated protein cas6,L,42,10,2.95608E-15
COG0663,Transferase,R,118,10,2.722E-15
COG4712,rad52 22 double-strand break repair protein,S,75,10,2.40989E-15
NOG02169,Histidine kinase,T,79,10,2.32752E-15
NOG40955,MTH538 TIR-like domain (DUF1863),S,53,11,2.04635E-15
NOG69955,[NoAnn],S,59,10,1.90555E-15
NOG13285,[NoAnn],S,62,12,1.65455E-15
NOG215092,[NoAnn],S,88,10,1.61592E-15
NOG76113,FlgN protein,S,71,20,1.58973E-15
COG0414,Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity),H,80,10,1.55586E-15
COG4713,membrAne,S,62,10,1.52221E-15
COG0670,Membrane,S,57,10,1.42006E-15
NOG17730,abc transporter permease protein,P,86,12,1.34413E-15
NOG82020,AP2 domain,S,77,10,1.34375E-15
NOG14369,LysR family transcriptional regulator,K,72,10,1.33019E-15
COG2949,SanA protein,S,66,10,1.26123E-15
COG1239,magnesium chelatase,H,49,12,1.18507E-15
NOG05330,radical SAM domain protein,R,87,10,1.17233E-15
NOG01371,F420-0:Gamma-glutamyl ligase,S,67,10,1.14952E-15
COG0616,"Signal peptide peptidase, SppA",O,45,10,1.07195E-15
NOG68615,phage structural protein,S,93,10,1.04068E-15
NOG65357,[NoAnn],S,90,10,1.0141E-15
COG1928,Dolichyl-phosphate-mannose--protein mannosyltransferase,O,78,10,9.84031E-16
NOG72037,[NoAnn],S,75,10,9.36529E-16
NOG95261,[NoAnn],S,75,10,8.88754E-16
NOG82073,Domain of unknown function (DUF378),S,60,10,8.69531E-16
NOG104914,DNA-binding helix-turn-helix protein,K,25,10,8.58263E-16
COG1146,4fe-4S ferredoxin iroN-sulfur binding,C,75,10,8.22274E-16
NOG215425,FlgN protein,S,38,10,7.9857E-16
COG4127,restriction endonuclease,V,56,10,7.71066E-16
NOG79751,[NoAnn],S,67,10,7.70851E-16
NOG11549,Nucleotidyl transferase of unknown function (DUF1814),S,77,10,7.60616E-16
COG0509,The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity),E,68,10,7.53976E-16
NOG39579,[NoAnn],S,29,10,7.35812E-16
NOG10722,"N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits",S,39,10,7.23117E-16
NOG212470,Nucleotidyl transferase of unknown function (DUF1814),S,34,10,7.15673E-16
NOG93649,DNA-binding helix-turn-helix protein,S,34,10,7.12871E-16
COG2814,Major Facilitator,G,59,10,7.08769E-16
NOG74459,s-layer domain-containing protein,S,56,10,7.05446E-16
COG3181,extra-cytoplasmic solute receptor family protein,S,113,10,6.89931E-16
NOG110921,peptidase M42 family protein,R,74,10,6.66953E-16
COG0499,May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity),H,74,10,6.56293E-16
NOG06248,[NoAnn],S,79,11,6.37685E-16
COG0199,"Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)",J,162,10,6.36593E-16
COG3653,Deacylase,Q,86,10,6.24072E-16
COG4898,conserved protein UCP033199,S,30,10,6.21425E-16
NOG78073,BioY family,S,48,10,6.18099E-16
COG2191,Formylmethanofuran dehydrogenase subunit E,C,29,11,6.13865E-16
COG1995,Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity),H,57,10,6.11477E-16
NOG45270,[NoAnn],S,58,10,5.86851E-16
NOG62713,[NoAnn],S,106,10,5.79623E-16
NOG71794,adenosyl cobinamide kinase adenosyl cobinamide phosphate guanylyltransferase,S,45,10,5.66212E-16
COG4099,phospholipase Carboxylesterase,R,39,10,5.56303E-16
NOG219473,Helix-turn-helix,S,34,10,5.26414E-16
NOG26137,Type I restriction modification DNA specificity domain,V,76,10,5.24844E-16
NOG56853,[NoAnn],S,45,10,5.14573E-16
NOG41136,[NoAnn],S,92,10,5.12975E-16
NOG135087,[NoAnn],S,44,10,5.08424E-16
NOG76249,Transcriptional regulator,K,65,10,5.06431E-16
NOG10938,Protein of unknown function (DUF2804),S,96,10,5.03693E-16
COG1658,Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity),L,82,10,4.97787E-16
NOG44540,galactofuranosyltransferase,S,45,10,4.95181E-16
NOG59052,Domain of unknown function (DUF955),S,73,10,4.87403E-16
NOG81693,[NoAnn],S,69,10,4.72116E-16
NOG14006,Protein of unknown function (DUF541),S,67,10,4.72036E-16
NOG102050,stage II sporulation protein,S,49,10,4.69196E-16
NOG26606,[NoAnn],S,49,10,4.59777E-16
NOG30521,s-layer protein,S,135,10,4.59672E-16
NOG47450,Plasmid stabilization system,S,44,10,4.51763E-16
COG3290,signal transduction histidine kinase regulating citrate malate metabolism,T,58,10,4.5159E-16
NOG81292,[NoAnn],S,86,10,4.50594E-16
NOG98952,Glycosyl transferase group 1,S,30,10,4.439E-16
NOG82587,(LipO)protein,S,76,10,4.42378E-16
NOG00108,Dehydrogenase,C,49,10,4.3904E-16
NOG105344,[NoAnn],S,56,10,4.3897E-16
NOG27147,Membrane associated,S,57,10,4.3597E-16
NOG31033,response regulator,T,52,10,4.30532E-16
NOG212300,Histidine kinase,T,73,10,4.28124E-16
NOG02023,Histidine kinase,T,106,11,4.27843E-16
NOG213808,glycosyl transferase family,M,79,10,4.27763E-16
NOG95779,HTH_XRE,S,49,10,4.27388E-16
NOG31406,xylose isomerase domain-containing protein tim barrel,G,60,10,4.21025E-16
NOG63947,cytoplasmic protein,S,92,10,4.20984E-16
NOG102117,[NoAnn],S,56,10,4.12728E-16
NOG01477,[NoAnn],S,66,10,4.09167E-16
NOG104497,Ribosomal protein L7AE,J,53,10,4.08429E-16
COG0861,membrane protein terC,P,38,10,3.99868E-16
COG1392,Phosphate transport regulator,P,79,10,3.98075E-16
NOG69450,Transcriptional regulator,K,48,10,3.79561E-16
NOG67131,Transposase (IS4 family protein),L,45,10,3.79248E-16
NOG62882,[NoAnn],S,117,10,3.75753E-16
COG0243,molybdopterin oxidoreductase,C,94,10,3.73682E-16
COG3603,amino acid-binding act domain-containing protein,S,68,10,3.653E-16
COG2022,"Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)",H,85,10,3.60968E-16
COG0145,5-oxoprolinase,E,53,10,3.60645E-16
NOG16523,[NoAnn],S,55,10,3.59667E-16
NOG94929,accessory gene regulator B,S,53,10,3.58373E-16
NOG18877,"Sigma-70, region 4",S,56,10,3.57287E-16
NOG81375,[NoAnn],S,29,10,3.56075E-16
COG1480,Metal Dependent Phosphohydrolase,R,62,10,3.49286E-16
NOG215905,Pfam:Exonuc_X-T,L,29,10,3.48858E-16
NOG02564,"extracellular solute-binding protein, family 1",G,131,10,3.46325E-16
NOG52805,[NoAnn],S,27,10,3.45427E-16
COG1353,crispr-associated protein,L,81,10,3.43717E-16
NOG64407,"acetyltransferase, (GNAT) family",R,72,10,3.42033E-16
NOG139870,"extracellular solute-binding protein, family 1",R,63,10,3.41869E-16
NOG23913,Pantothenate kinase,H,64,10,3.40255E-16
NOG00285,[NoAnn],S,71,10,3.39088E-16
COG2048,heterodisulfide reductase,C,75,10,3.38069E-16
NOG04185,Major Facilitator superfamily,G,54,10,3.37495E-16
COG5525,terminase (large subunit),R,113,10,3.37152E-16
COG1558,flagellar basal-body rod protein flgc,N,77,10,3.37082E-16
NOG92393,DNAj domain protein,O,66,10,3.37015E-16
NOG29596,[NoAnn],S,109,10,3.36995E-16
COG3629,Transcriptional regulator,K,49,10,3.36654E-16
COG3822,Protein of unknown function (DUF1498),S,121,10,3.36574E-16
COG3882,FkbH Like Protein,Q,56,10,3.36471E-16
NOG212461,alpha-L-rhamnosidase,S,68,10,3.3638E-16
NOG97909,[NoAnn],S,49,10,3.36262E-16
NOG86889,Staphylococcal protein of unknown function (DUF960),S,32,10,3.36154E-16
NOG99484,[NoAnn],S,76,10,3.36145E-16
COG3051,"citrate lyase, alpha",C,50,10,3.36089E-16
NOG17810,"terminase, large subunit",R,39,10,3.36089E-16
COG1841,50S ribosomal protein L30,J,110,10,3.3607E-16
COG1766,The M ring may be actively involved in energy transduction (By similarity),N,78,10,3.36063E-16
COG2317,Carboxypeptidase,E,82,11,2.55622E-16
NOG92956,[NoAnn],S,41,11,2.17124E-16
NOG31616,Pfam:UPF0153,S,94,12,1.83901E-16
NOG33926,Transcriptional regulator,K,57,11,1.70136E-16
NOG63354,conjugative transposon protein,S,72,11,1.67098E-16
NOG66027,ppic-type ppiase domain,S,49,11,1.65396E-16
NOG64490,"nucleotidyltransferase substrate binding protein, HI0074 family",R,74,11,1.39944E-16
COG0384,"phenazine biosynthesis protein, phzf family",R,72,11,1.2786E-16
NOG87258,divIVA domain,S,63,11,1.18973E-16
NOG00322,binding-protein-dependent transport systems inner membrane Component,G,66,11,1.1189E-16
COG1516,flagellar protein FliS,N,80,21,1.07599E-16
COG5433,Transposase,L,54,11,1.02012E-16
COG2243,Precorrin-2 c20-methyltransferase,H,82,11,9.82433E-17
COG1043,"Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)",M,35,11,9.56129E-17
NOG118412,[NoAnn],S,55,11,7.43823E-17
COG0022,"Dehydrogenase, E1 component",C,66,11,7.00909E-17
NOG72188,Glyoxalase Bleomycin resistance protein (Dioxygenase,R,54,11,6.93535E-17
NOG213548,nitroreductase,S,36,11,6.41697E-17
NOG79677,[NoAnn],S,171,15,5.84062E-17
NOG36367,Abc-2 type transporter,R,61,11,5.6053E-17
NOG66675,"regulator, Fur family",K,95,11,5.58865E-17
NOG00052,drug resistance transporter emrb qaca subfamily,P,39,11,5.48852E-17
NOG41848,Histidine kinase,T,68,11,4.97852E-17
NOG37793,phage protein,S,92,11,4.66723E-17
COG4936,Histidine kinase,T,83,11,4.41787E-17
NOG48860,selenium metabolism protein yedf,S,93,11,4.41182E-17
COG2079,MMGE PRPD family protein,R,62,11,4.12863E-17
NOG08760,Atp-binding protein,R,50,11,3.94903E-17
NOG55793,Membrane,S,100,11,3.71014E-17
NOG20965,[NoAnn],S,63,11,3.66472E-17
COG3583,domain protein,S,92,11,3.48958E-17
NOG00194,"Glycosyl transferase, family 2",M,124,15,3.44985E-17
NOG02019,tetratricopeptide repeat protein,S,80,11,3.44851E-17
NOG52198,toxin secretion phage lysis holin,S,53,11,3.35116E-17
NOG104044,[NoAnn],S,60,11,3.22263E-17
NOG49978,[NoAnn],S,100,15,3.08423E-17
NOG08877,Bacterial membrane protein YfhO,S,53,11,2.95793E-17
COG4717,domain protein,S,56,11,2.89737E-17
NOG05788,stage III sporulation protein ae,S,138,11,2.89646E-17
COG2204,"two component, sigma54 specific, transcriptional regulator, Fis family",T,51,11,2.87731E-17
COG5039,Polysaccharide pyruvyl transferase,M,62,11,2.80212E-17
NOG103831,[NoAnn],S,82,11,2.79635E-17
NOG43310,transposase,L,37,11,2.79171E-17
COG0403,The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor,E,67,11,2.62641E-17
COG3307,O-Antigen Polymerase,M,62,11,2.5518E-17
COG2234,peptidase m28,R,68,11,2.50218E-17
NOG83788,Transcriptional regulator,K,77,11,2.47908E-17
COG4086,extracellular protein,S,74,12,2.40153E-17
COG1859,Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity),J,62,11,2.34635E-17
COG1270,Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity),H,85,11,2.33432E-17
COG4722,tail component,S,68,11,2.31513E-17
NOG54153,"transcriptional regulator, merr family",K,68,11,2.31002E-17
NOG211998,Type III restriction enzyme res subunit,V,61,11,2.24935E-17
NOG65200,[NoAnn],S,48,11,2.23556E-17
COG1652,lysm domain,S,106,11,2.21774E-17
NOG104360,[NoAnn],S,96,11,2.204E-17
COG4864,UPF0365 protein,S,82,11,2.20139E-17
COG1539,dihydroneopterin aldolase,H,95,11,2.17556E-17
NOG22370,[NoAnn],S,72,11,2.11463E-17
COG0720,synthase,H,99,11,2.10204E-17
COG0723,"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)",C,132,11,2.09074E-17
NOG78891,cytoplasmic protein,S,98,11,2.08352E-17
NOG83138,Transcriptional regulator,K,41,11,2.06663E-17
NOG46321,antar domain protein,S,86,11,2.06267E-17
NOG101266,"hypothetical protein, partial",S,59,11,2.05495E-17
NOG64804,[NoAnn],S,156,11,2.01208E-17
NOG09503,O-Methyltransferase,S,84,11,1.99919E-17
NOG01100,PhosPhorylase,S,97,11,1.99176E-17
COG2032,Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity),P,67,11,1.90067E-17
NOG102482,Protein of unknown function (DUF464),S,60,11,1.89221E-17
NOG211928,[NoAnn],S,78,11,1.87682E-17
NOG12183,[NoAnn],S,75,11,1.86858E-17
NOG23667,ABC transporter (permease),V,48,11,1.85872E-17
NOG10810,methyltransferase,M,100,11,1.84685E-17
COG4189,Transcriptional regulator,K,65,11,1.83465E-17
COG2515,1-aminocyclopropane-1-carboxylate deaminase,E,56,11,1.8104E-17
NOG87034,[NoAnn],S,40,11,1.78272E-17
COG2365,protein tyrosine serine phosphatase,T,103,11,1.77985E-17
NOG20258,atp-binding protein,S,57,11,1.7435E-17
NOG09389,Transcriptional regulator,K,53,11,1.73342E-17
COG0291,50s ribosomal protein L35,J,104,11,1.67019E-17
COG2160,Catalyzes the conversion of L-arabinose to L-ribulose (By similarity),G,116,11,1.66972E-17
COG5401,germination protein,R,81,11,1.65896E-17
NOG10791,[NoAnn],S,75,11,1.65843E-17
NOG19353,2-hydroxyglutaryl-CoA dehydratase,S,89,11,1.63757E-17
NOG102439,domain protein,S,77,11,1.63263E-17
NOG223225,[NoAnn],S,47,11,1.62339E-17
NOG31663,isochorismatase,Q,52,11,1.62089E-17
NOG65276,Hnh endonuclease,V,71,11,1.59963E-17
NOG112910,Sporulation initiation factor Spo0A domain protein,S,55,11,1.5919E-17
NOG02103,CRISPR-associated protein Csd1 family,L,169,11,1.5802E-17
NOG76168,[NoAnn],S,54,11,1.55561E-17
COG3640,"cobyrinic Acid a,c-diamide synthase",D,132,11,1.5495E-17
NOG80680,Transcriptional regulator (XRE family,K,57,11,1.5437E-17
NOG31115,transcriptional regulator (AraC family),K,112,12,1.53383E-17
NOG02877,DNA maturase,S,33,11,1.5267E-17
COG1039,Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity),L,80,11,1.50679E-17
COG1633,Rubrerythrin,S,85,12,1.49794E-17
NOG216562,[NoAnn],S,48,11,1.49379E-17
NOG10083,Metal Dependent Phosphohydrolase,R,66,11,1.49017E-17
NOG22654,[NoAnn],S,31,11,1.49008E-17
NOG101724,[NoAnn],S,34,11,1.49001E-17
COG2426,small multi-drug export,S,93,11,1.48881E-17
NOG05837,[NoAnn],S,88,11,1.46844E-17
NOG32355,Cytidylate kinase,S,84,11,1.46643E-17
COG1003,The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor,E,69,11,1.46578E-17
NOG84893,Protein of unknown function (DUF1064),S,80,11,1.46298E-17
NOG13035,K07001 NTE family protein,R,87,11,1.46094E-17
NOG64746,(sortase) family,S,91,11,1.46087E-17
NOG40262,"transcriptional regulator, MarR family",K,72,11,1.46017E-17
COG1587,Uroporphyrinogen-III synthase,H,71,11,1.45963E-17
NOG41151,Protein of unknown function DUF115,S,47,11,1.45767E-17
NOG03180,oxidoreductase,R,37,11,1.45713E-17
NOG51513,[NoAnn],S,24,11,1.45703E-17
COG1298,Flagellar biosynthesis protein flha,N,97,11,1.45626E-17
NOG28104,integral membrane protein TIGR02185,S,47,11,1.45561E-17
NOG222340,ERF superfamily,S,35,11,1.45559E-17
NOG71625,[NoAnn],S,81,11,1.45557E-17
NOG18345,extracellular solute-binding protein family 1,G,68,11,1.45541E-17
NOG218477,Thiamine biosynthesis protein thiS,H,20,11,1.4554E-17
COG1273,Could be involved in DNA repair (By similarity),L,49,12,1.40701E-17
NOG61190,DnaD domain protein,S,92,13,1.36919E-17
COG0010,agmatinase (EC 3.5.3.11),E,139,13,1.11328E-17
NOG101261,"transcriptional regulator, merr family",K,78,14,9.64133E-18
COG0368,Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity),H,81,12,9.16335E-18
NOG48154,[NoAnn],S,47,12,8.41611E-18
COG1067,atp-dependent protease,O,110,14,6.84661E-18
COG4684,membrAne,S,77,12,6.40215E-18
NOG212478,methyltransferase,R,62,18,6.31993E-18
NOG01410,Integrase catalytic subunit,L,86,12,4.90078E-18
NOG02455,Glycosyl Hydrolase Family 88,R,80,13,4.8588E-18
NOG83536,Transcriptional regulator,K,73,12,3.78438E-18
COG0780,Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity),R,90,12,3.67557E-18
NOG01575,M protein-like MukB domain-containing protein,S,71,12,3.32718E-18
COG5012,cobalamin b12-binding domain protein,R,77,13,3.17505E-18
NOG100846,[NoAnn],S,51,12,3.08964E-18
COG4154,RbsD or FucU transport,G,88,12,3.03608E-18
NOG117312,[NoAnn],S,41,12,2.37865E-18
NOG90223,Helix-turn-helix,K,54,12,2.37736E-18
NOG41940,Gcn5-related n-acetyltransferase,R,92,12,2.34646E-18
COG1038,"Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)",C,64,12,2.12716E-18
COG2452,Resolvase domain protein,L,64,12,1.98482E-18
COG4880,beta propeller domain protein,S,88,12,1.97544E-18
NOG06091,[NoAnn],S,45,12,1.87675E-18
NOG212021,Major Facilitator,G,158,12,1.86565E-18
NOG10943,F420-0:Gamma-glutamyl ligase,S,114,12,1.83474E-18
NOG63324,Prophage pi2 protein 37,S,96,13,1.8217E-18
NOG43477,domain) protein,S,69,12,1.81876E-18
NOG02832,"Glycosyl transferase, family 2",M,102,14,1.80019E-18
NOG01275,Glycosyl transferase group 1,M,86,12,1.67071E-18
COG0315,"Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)",H,77,12,1.62433E-18
NOG80335,"Addiction module antitoxin, RelB DinJ family",L,77,12,1.57639E-18
NOG79810,septum formation initiator,S,70,12,1.55772E-18
NOG54976,[NoAnn],S,118,12,1.48026E-18
NOG15202,replication,L,99,13,1.35674E-18
COG1352,Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP (By similarity),N,73,12,1.32259E-18
COG2087,Adenosylcobinamide kinase,H,73,12,1.27674E-18
NOG85528,YqaJ-like viral recombinase domain,S,37,12,1.27579E-18
NOG63419,"Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)",S,76,12,1.26042E-18
NOG69308,VRR-NUC domain protein,S,106,12,1.2527E-18
COG3442,Glutamine amidotransferase,R,111,12,1.22587E-18
NOG05478,cell wall surface anchor family protein,S,102,12,1.21972E-18
NOG55628,P-loop domain protein,R,76,12,1.19113E-18
COG1071,Dehydrogenase,C,81,12,1.19016E-18
NOG43137,[NoAnn],S,49,12,1.17542E-18
COG1225,alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen,O,120,15,1.11969E-18
NOG28218,[NoAnn],S,66,12,1.10515E-18
NOG02081,[NoAnn],S,61,12,1.0568E-18
COG2423,Ornithine Cyclodeaminase,E,97,15,1.04888E-18
COG3550,domain protein,R,111,12,9.86326E-19
NOG30960,[NoAnn],S,70,15,9.74131E-19
COG1797,"Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)",H,81,12,9.57793E-19
COG2852,"DNA cytosine-5,-methyltransferase",S,123,12,9.21509E-19
NOG212396,"CRISPR-associated protein, Csd1 family",L,73,16,9.19579E-19
NOG84194,hydrolase family,M,48,12,9.1935E-19
NOG10955,atp gtp-binding protein,S,43,12,9.16367E-19
NOG89559,Protein of unknown function (DUF2953),S,61,12,9.14077E-19
NOG47106,[NoAnn],S,143,12,9.13392E-19
NOG70887,[NoAnn],S,72,12,9.03397E-19
COG0157,nicotinate-nucleotide pyrophosphorylase,H,94,12,8.94892E-19
NOG79692,domain protein,R,85,12,8.89973E-19
COG0666,Ankyrin Repeat,R,101,12,8.77866E-19
COG0113,delta-aminolevulinic acid dehydratase,H,69,12,8.73574E-19
COG4951,"Type III restriction protein, res subunit",L,61,12,8.73417E-19
NOG80945,"Toxin-antitoxin system, toxin component, RelE family",S,48,12,8.64744E-19
NOG70667,Pfam:DUF304,S,105,12,8.57759E-19
NOG214312,[NoAnn],S,106,12,8.53483E-19
NOG23866,[NoAnn],S,63,12,8.22383E-19
COG3608,succinylglutamate desuccinylase aspartoacylase,S,110,26,8.22341E-19
NOG08066,[NoAnn],S,83,12,8.19398E-19
NOG35004,Histidine triad,S,53,12,8.1562E-19
COG2339,Involved in the degradation of specific anti-sigma factors (By similarity),S,70,12,8.07613E-19
NOG34660,Hd domain protein,R,63,12,8.02958E-19
NOG38413,PAP2 Family,S,141,13,8.02207E-19
NOG102109,Helix-turn-helix,S,125,12,8.02042E-19
NOG13741,methionine sulfoxide reductase A,S,118,12,7.80179E-19
NOG54021,phosphoadenosine phosphosulfate reductase,S,67,12,7.76376E-19
COG3835,regulatoR,K,77,12,7.74704E-19
NOG08483,Reverse transcriptase,L,50,14,7.67516E-19
NOG55645,s-layer protein,S,125,12,7.44126E-19
NOG35747,(Rhomboid) family,R,82,12,7.43429E-19
COG2241,"precorrin-6y C5,15-methyltransferase",H,75,12,7.35382E-19
COG2242,"precorrin-6y C5,15-methyltransferase",H,87,12,7.35382E-19
COG2158,Cysteine-rich small domain protein,R,52,12,7.35318E-19
NOG11553,AAA domain (dynein-related subfamily),R,93,13,7.3214E-19
COG4211,permease protein,G,109,12,7.2896E-19
NOG42549,[NoAnn],S,52,12,7.15145E-19
NOG12139,Xylose isomerase domain protein TIM barrel,G,86,12,7.14034E-19
COG3804,dihydrodipicolinate reductase,S,81,12,6.89084E-19
NOG05922,alpha-L-rhamnosidase,S,52,12,6.87058E-19
COG2895,"may be the GTPase, regulating ATP sulfurylase activity (By similarity)",P,54,12,6.80113E-19
COG3274,Membrane,S,91,12,6.73169E-19
COG2030,maoc domain protein dehydratase,I,64,12,6.72007E-19
NOG50618,"Glycosyl transferase, family 2",M,88,12,6.67702E-19
NOG36881,[NoAnn],S,53,12,6.64771E-19
NOG43424,"Peptidase C11, clostripain",S,49,12,6.5574E-19
NOG05314,[NoAnn],S,85,12,6.53761E-19
COG4670,CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity),I,105,12,6.50668E-19
COG1424,Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity),H,33,12,6.47385E-19
COG3267,General secretion pathway protein,U,43,13,6.3874E-19
NOG65455,Transcriptional regulator,K,28,12,6.36939E-19
NOG62970,[NoAnn],S,124,12,6.35921E-19
COG3633,"Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)",E,92,12,6.33901E-19
NOG68927,[NoAnn],S,39,12,6.33168E-19
COG1543,hydrolase family 57,G,55,12,6.32313E-19
COG2942,n-acylglucosamine 2-epimerase,G,62,12,6.30638E-19
COG2831,"Polypeptide-transport-associated domain protein, ShlB-type",U,75,12,6.30603E-19
COG0209,Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity),F,121,12,6.30541E-19
NOG66095,XkdN-like protein,S,80,12,6.30532E-19
NOG62102,Host cell surface-exposed lipoprotein,S,67,12,6.30434E-19
NOG08386,Histidine kinase,T,76,13,3.21739E-19
NOG09896,Exopolysaccharide biosynthesis protein,S,53,13,2.85121E-19
NOG212135,[NoAnn],S,65,13,2.79282E-19
COG1433,Dinitrogenase iron-molybdenum cofactor biosynthesis protein,S,122,13,2.37022E-19
COG4213,(ABC) transporter,G,79,13,1.96393E-19
COG1679,Aconitase subunit 1,S,93,13,1.6018E-19
COG0603,Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity),R,97,13,1.44858E-19
COG4420,integral membrane protein,S,145,15,1.41223E-19
COG1585,Membrane,O,78,13,1.40192E-19
NOG46199,"Putative transposase, YhgA-like",S,77,14,1.30159E-19
NOG82121,"Prophage LambdaCh01, transcriptional regulator",K,51,13,1.25663E-19
NOG69166,Domain of unknown function (DUF955),S,92,13,1.16577E-19
NOG51548,DNA N-6-adenine-methyltransferase,L,78,13,1.16569E-19
NOG210978,[NoAnn],S,46,13,1.16472E-19
NOG71456,[NoAnn],S,64,14,1.127E-19
NOG79131,redox-active disulfide protein 2,S,55,13,1.03987E-19
NOG53279,[NoAnn],S,75,13,1.02334E-19
COG4989,Aldo keto reductase,C,62,13,1.01295E-19
NOG88462,[NoAnn],S,94,13,9.38848E-20
NOG215408,HTH_XRE,K,49,14,9.29562E-20
COG4889,helicase,L,72,13,8.88598E-20
NOG24471,(ABC) transporter,P,59,13,8.4743E-20
COG3090,Tripartite ATP-independent periplasmic transporter dctq component,G,159,13,7.81365E-20
COG1781,Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity),F,103,13,7.39543E-20
NOG16170,"Carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-)",R,46,14,7.28302E-20
NOG212172,"Type iii restriction enzyme, res subunit",V,61,13,7.17113E-20
COG0701,permease,R,122,15,7.14098E-20
COG4149,molybdate abc transporter,P,106,13,6.94214E-20
NOG50533,tail protein,S,78,13,6.80257E-20
NOG87480,"Toxin-antitoxin system, toxin component, HicA family",S,46,14,6.77788E-20
COG4463,"transcriptional regulator, ctsr",K,168,17,6.48792E-20
NOG62060,Membrane,S,93,13,6.43366E-20
NOG169068,[NoAnn],S,128,13,6.29675E-20
NOG22425,Transposase (IS4 family,L,114,13,6.2659E-20
NOG56506,[NoAnn],S,78,13,6.15436E-20
NOG227376,[NoAnn],S,37,13,5.94178E-20
NOG83226,[NoAnn],S,119,13,5.89673E-20
NOG64130,[NoAnn],S,20,13,5.51542E-20
COG1144,"oxidoreductase, delta subunit",C,82,13,5.51391E-20
NOG99122,phage protein,S,45,13,5.42012E-20
NOG02818,PglZ domain protein,S,110,13,5.36003E-20
COG0725,"ABC transporter, periplasmic molybdate-binding protein",P,120,13,5.26836E-20
COG5511,Phage portal protein lambda family,R,128,13,5.2562E-20
NOG00561,Endonuclease,S,101,13,5.22606E-20
COG0132,"Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)",H,78,13,5.21664E-20
NOG20487,Antirestriction protein,S,136,13,5.09762E-20
NOG30139,Hydrolase,R,74,14,4.86624E-20
COG3695,methyltransferase,L,111,13,4.68363E-20
NOG213349,Histidine kinase,T,118,13,4.63968E-20
NOG63197,protein conserved in bacteria (DUF2325),S,125,13,4.39858E-20
COG0512,anthranilate synthase,E,132,15,4.29137E-20
COG4747,ACT domain protein,E,121,13,4.26132E-20
COG1661,DNA-binding protein,S,88,13,4.15776E-20
NOG213456,helix-turn-helix protein,K,73,13,4.08709E-20
COG1776,CheC --inhibitor of MCP methylation,N,118,13,4.02601E-20
NOG64038,CHP02436-containing protein,S,101,13,3.99519E-20
NOG83108,[NoAnn],S,65,13,3.93826E-20
COG0365,"Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)",I,136,13,3.90521E-20
COG0651,Monovalent cation H antiporter subunit D,C,125,13,3.86482E-20
NOG21720,domain protein,S,49,13,3.82569E-20
NOG03318,"Extracellular solute-binding protein, family 5",R,29,13,3.71198E-20
NOG101197,[NoAnn],S,77,13,3.55391E-20
NOG63942,Drtgg domain protein,S,112,13,3.51331E-20
NOG54923,atp gtp-binding protein,S,118,13,3.50467E-20
NOG01637,hydrolase family 43,G,69,13,3.4149E-20
COG3238,membrAne,S,101,13,3.41238E-20
NOG212364,Antioxidant AhpC Tsa family,O,65,13,3.37702E-20
NOG23922,site-specific recombinase,L,67,13,3.36811E-20
COG0547,Anthranilate phosphoribosyltransferase,E,165,13,3.35223E-20
COG3950,Atp-binding protein,R,117,13,3.30746E-20
NOG04108,[NoAnn],S,51,13,3.29295E-20
COG4926,Phage minor structural protein,S,138,13,3.2818E-20
NOG87120,Anaerobic ribonucleoside-triphosphate reductase,S,76,13,3.25941E-20
NOG102642,3D domain protein,S,83,14,3.19261E-20
COG3512,"CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)",L,102,13,3.17114E-20
NOG67402,stage III sporulation protein AH,S,98,13,3.12922E-20
COG4295,Uncharacterized protein conserved in bacteria (DUF2263),S,67,13,3.11025E-20
NOG56040,[NoAnn],S,68,16,3.09218E-20
COG2099,precorrin-6x reductase,H,84,14,3.02806E-20
NOG76045,[NoAnn],S,84,13,3.0038E-20
NOG10413,VWA,R,65,13,2.89808E-20
COG1903,May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity),H,104,13,2.80727E-20
COG2815,Serine Threonine protein kinase,T,93,13,2.76316E-20
COG3876,conserved protein UCP016719,S,57,13,2.75122E-20
COG2390,Transcriptional regulator,K,120,13,2.74229E-20
NOG118268,ATP dependent DNA ligase domain,L,51,13,2.73749E-20
COG3976,fmN-binding domain protein,S,64,13,2.73333E-20
COG1156,Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity),C,126,13,2.73222E-20
NOG35591,N-6 DNA Methylase,S,123,14,2.37283E-20
COG0161,"Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)",E,83,14,2.28449E-20
NOG38366,"major tail protein, phi13 family",R,85,15,1.96025E-20
NOG30353,[NoAnn],S,58,14,1.95887E-20
NOG62578,Cell wall hydrolase Autolysin,R,130,17,1.67988E-20
NOG23909,n-acetylmuramoyl-l-alanine amidase,M,93,14,1.64403E-20
COG4930,atp-dependent,O,111,14,1.44652E-20
COG1277,(ABC) transporter,R,155,20,1.22207E-20
COG2909,Transcriptional regulator,K,118,14,1.1664E-20
NOG81533,Hpt domain,S,119,14,1.03956E-20
COG1445,PTS System,G,166,14,9.196E-21
COG1606,pp-loop domain protein,R,155,14,8.87223E-21
COG0794,Arabinose 5-phosphate isomerase,M,90,14,8.69862E-21
NOG38945,"acetyltransferase, (GNAT) family",R,86,14,8.38417E-21
COG1699,"Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)",S,60,14,7.64152E-21
NOG05131,transposase,L,75,14,7.37099E-21
COG1299,pts system,G,172,14,7.35685E-21
COG0182,Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity),J,121,15,6.16742E-21
NOG11497,[NoAnn],S,167,14,5.707E-21
NOG27821,Pilin isopeptide linkage domain protein,S,32,15,5.3379E-21
NOG08974,Integrase,S,119,14,5.25672E-21
COG1204,helicase,L,97,14,5.01465E-21
NOG30386,"Two component transcriptional regulator, winged helix family",T,139,14,4.86501E-21
NOG73920,[NoAnn],S,107,14,4.68657E-21
COG0684,Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity),H,75,14,4.3842E-21
NOG68073,group 2 family,M,69,14,3.88301E-21
NOG61387,Protein of unknown function (DUF1643),S,72,16,3.81538E-21
COG2152,Glycosidase,G,101,14,3.73336E-21
NOG02227,Modification methylase EcoRI,L,113,16,3.51619E-21
COG0159,The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity),E,132,14,3.39248E-21
NOG82244,[NoAnn],S,42,14,3.1634E-21
NOG09982,transposase,L,102,14,3.13763E-21
COG1957,nucleoside hydrolase,F,129,14,3.09049E-21
COG0302,GTP cyclohydrolase i,H,110,14,3.03161E-21
NOG213506,Transcriptional regulator (XRE family,K,94,14,3.02266E-21
COG0496,Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity),F,84,14,2.98206E-21
NOG78985,Preprotein translocase SecG subunit,U,76,14,2.97748E-21
COG0580,Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity),G,74,14,2.94948E-21
COG0730,Membrane,S,154,16,2.82622E-21
COG3716,PTS system mannose fructose sorbose family IID component,G,127,15,2.73239E-21
NOG12431,transposase IS605 OrfB family,L,98,14,2.71645E-21
NOG01802,[NoAnn],S,88,16,2.6721E-21
COG0688,Phosphatidylserine decarboxylase,I,95,14,2.64297E-21
NOG36677,[NoAnn],S,75,15,2.52733E-21
NOG43694,Phosphoglycerate mutase,G,106,14,2.44529E-21
NOG80037,Phosphopantetheine attachment site. (EC 6.1.1.13),S,89,14,2.30049E-21
NOG29473,"CRISPR-associated protein, Csm6",L,70,14,2.27574E-21
COG3411,Ferredoxin,C,89,16,2.1841E-21
NOG101231,capsular polysaccharide biosynthesis protein,S,73,14,2.13093E-21
NOG51588,[NoAnn],S,215,14,2.12122E-21
NOG51310,LysM domain,S,104,14,2.09048E-21
COG3263,Potassium proton antiporter,P,85,14,2.08313E-21
NOG01331,stage II sporulation protein E,T,100,14,2.01302E-21
COG2301,citrate lyase,G,79,14,1.96257E-21
NOG62515,Transcriptional regulator,K,124,18,1.95526E-21
NOG101601,"small, acid-soluble spore protein",S,86,14,1.88154E-21
NOG44015,DNA-binding helix-turn-helix protein,K,118,14,1.83055E-21
COG1954,glycerol-3-phosphate responsive antiterminator,K,99,14,1.79874E-21
COG0433,Aaa atpase,R,126,14,1.79205E-21
COG3191,peptidase s58 dmpa,E,104,14,1.78992E-21
NOG215164,Listeria-Bacteroides repeat domain (List_Bact_rpt),S,64,14,1.74324E-21
NOG49237,Bacteriophage Gp15 protein,S,93,14,1.74279E-21
COG4443,conserved domain protein,S,124,14,1.74144E-21
COG3333,membrane,S,102,14,1.73911E-21
NOG29602,[NoAnn],S,114,14,1.73223E-21
COG2039,Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity),O,84,14,1.73203E-21
COG4495,[NoAnn],S,67,16,1.69733E-21
COG0225,Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity),O,77,14,1.69065E-21
COG0413,"Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)",H,87,14,1.67441E-21
NOG79441,Helix-turn-helix,S,71,14,1.66044E-21
NOG33469,[NoAnn],S,107,14,1.64666E-21
NOG12406,[NoAnn],S,108,14,1.64277E-21
NOG10188,[NoAnn],S,83,14,1.64033E-21
NOG73194,[NoAnn],S,64,14,1.63871E-21
NOG14690,Atp-binding protein,S,63,14,1.635E-21
NOG103255,[NoAnn],S,86,14,1.61388E-21
NOG01262,"ATP synthase, subunit",C,49,14,1.59751E-21
NOG40481,Abi-like protein,S,52,14,1.55567E-21
NOG14229,[NoAnn],S,52,14,1.55115E-21
NOG42960,Phage integrase family,L,79,14,1.52597E-21
NOG39715,(ABC) transporter,P,75,14,1.49244E-21
COG0189,Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity),H,71,14,1.48241E-21
NOG102226,DNA polymerase beta domain protein region,R,70,14,1.45036E-21
NOG80997,Spore coat peptide assembly protein,S,112,14,1.44842E-21
COG0859,heptosyltransferase,M,109,14,1.42945E-21
COG1492,"catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)",H,96,14,1.42864E-21
COG0728,Integral membrane protein (MviN,R,94,14,1.4241E-21
NOG213594,Histidine kinase,T,70,14,1.40343E-21
COG3610,Membrane,S,95,14,1.3985E-21
COG3869,ATP guanido phosphotransferase,E,133,14,1.3558E-21
NOG102043,Transcriptional regulator,K,107,14,1.34442E-21
NOG79030,"DNA binding domain protein, excisionase family",L,134,14,1.32926E-21
COG2068,4-diphosphocytidyl-2c-methyl-d-erythritol synthase,S,121,15,1.328E-21
NOG87657,domain protein,S,118,14,1.27281E-21
NOG07384,Glycosyl transferase (Group 1,M,123,14,1.27049E-21
COG0306,phosphate transporter,P,79,14,1.24172E-21
COG0134,indole-3-glycerol phosphate synthase,E,131,14,1.23528E-21
NOG43408,Domain of unknown function (DUF1788),S,88,17,1.21942E-21
NOG40188,Acyl-transferase,S,67,14,1.21228E-21
NOG118355,Zonular occludens toxin (Zot),S,52,14,1.19678E-21
COG4639,serine threonine protein phosphatase,R,92,14,1.19608E-21
COG3593,ATP-dependent endonuclease of the OLD,L,88,14,1.19183E-21
COG1078,Metal Dependent Phosphohydrolase,R,93,14,1.18587E-21
NOG68676,capsid protein,R,76,14,1.18528E-21
NOG31428,"sigma-70, region 4",S,66,14,1.18519E-21
NOG62896,"Glycosyl hydrolase, family 25",M,117,14,1.18493E-21
COG2073,cobalamin (vitamin B12) biosynthesis CbiG protein,H,98,14,1.18313E-21
NOG42992,"spore coat protein, CotS",M,88,14,1.18258E-21
COG0007,Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity),H,100,15,7.11853E-22
COG0391,"Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP (By similarity)",S,122,17,6.45761E-22
NOG46871,DNA metabolism protein,S,100,15,6.09076E-22
NOG23172,"Transcriptional regulator, TetR family",K,37,16,5.64049E-22
NOG62080,"transcriptional regulator), MarR family",K,116,15,5.34873E-22
COG3525,ec 3.2.1.52,G,119,15,4.74817E-22
NOG39474,[NoAnn],S,59,15,4.24157E-22
NOG101893,FHA domain,T,97,17,3.86587E-22
COG0140,phosphoribosyl-ATP pyrophosphatase,E,146,16,3.16407E-22
NOG38013,"Metal-dependent phosphohydrolase, HD sub domain",R,108,15,3.00278E-22
NOG51984,sigma-e processing peptidase spoiiga,R,138,15,2.65381E-22
COG1118,(ABC) transporter,P,134,15,1.82884E-22
NOG15926,domain protein,S,80,15,1.74452E-22
COG4660,Electron transport complex,C,199,18,1.54248E-22
NOG03032,restriction,V,145,15,1.47837E-22
NOG215812,feoA family,P,71,15,1.3423E-22
NOG101731,VanZ-like protein,S,115,15,1.31437E-22
NOG01259,Pfam:DUF395,S,68,16,1.2147E-22
COG4227,antirestriction protein,L,97,16,1.18666E-22
NOG50492,integral membrane protein,S,66,15,1.129E-22
COG0133,The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity),E,158,15,1.12522E-22
COG3541,nucleotidyltransferase,S,111,15,1.10505E-22
COG2270,Major Facilitator superfamily,G,92,15,1.09755E-22
COG2771,Transcriptional regulator,K,83,15,1.03556E-22
COG2320,dephospho-CoA kinase protein folding accessory domain-containing protein,S,98,16,1.00913E-22
COG0421,"Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)",E,110,15,1.00515E-22
NOG34197,smc domain-containing protein,S,93,15,9.87376E-23
NOG03706,Transposase,L,112,15,9.76356E-23
COG2731,YhcH YjgK YiaL family protein,G,140,15,9.68069E-23
NOG214542,"acetyltransferase, (GNAT) family",R,66,15,9.56916E-23
NOG03108,Mate efflux family protein,V,124,15,9.33785E-23
COG1027,Aspartate ammonia-lyase,E,68,15,9.30157E-23
NOG11840,[NoAnn],S,118,15,9.29329E-23
COG1574,amidohydrolase,R,128,15,9.23732E-23
COG3383,Formate dehydrogenase Alpha subunit,C,74,15,9.19126E-23
NOG89401,[NoAnn],S,94,15,8.95028E-23
COG0483,inositol monophosphatase,G,111,15,8.91435E-23
COG0267,50S ribosomal protein L33,J,118,15,8.59888E-23
NOG07209,Histidine kinase,T,56,15,8.37294E-23
NOG83617,Bacteriophage peptidoglycan hydrolase ,R,69,15,8.05397E-23
NOG91409,Transcriptional regulator,K,72,15,7.89393E-23
NOG15557,[NoAnn],S,111,15,7.80559E-23
COG1794,aspartate racemase,E,106,15,7.79492E-23
NOG67661,"Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase",S,59,15,7.3766E-23
COG0665,"Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)",E,164,16,7.24656E-23
COG0825,"Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)",I,131,15,7.15055E-23
NOG08428,"Linear amide C-N hydrolases, choloylglycine hydrolase family",R,68,15,6.90336E-23
NOG79878,heavy metal-associated domain protein,S,187,25,6.77349E-23
COG1683,conserved protein,S,147,15,6.58753E-23
COG0586,SNARE associated Golgi,S,90,15,6.47014E-23
NOG01242,spore coat protein CotH,M,87,15,6.42852E-23
NOG28146,"acetyltransferase, (GNAT) family",R,102,15,6.18342E-23
COG2230,cyclopropane-fatty-acyl-phospholipid synthase,M,69,15,6.03545E-23
COG3883,CHAP domain protein,S,117,15,5.91717E-23
NOG216328,[NoAnn],S,70,15,5.55816E-23
NOG184859,S-layer homology domain,S,88,15,5.38055E-23
COG0392,Membrane,S,169,15,5.3706E-23
NOG26196,Helix-turn-helix,S,113,15,5.29897E-23
COG2258,mosc domain containing protein,S,83,15,5.23109E-23
NOG101725,Transcriptional regulator,K,70,15,5.22411E-23
COG3980,pseudaminic acid biosynthesis-associated protein PseG,M,51,16,5.21525E-23
COG2870,"Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)",M,91,15,5.19967E-23
COG1402,K01470 creatinine amidohydrolase EC 3.5.2.10,R,92,15,5.194E-23
NOG02900,sporulation peptidase YabG,R,110,15,5.19149E-23
NOG39088,Histidine kinase,T,110,15,5.1705E-23
NOG12805,tape measure,S,147,15,5.1683E-23
NOG15248,[NoAnn],S,86,15,5.14417E-23
NOG00891,[NoAnn],S,106,15,5.13264E-23
NOG70885,cyclic nucleotide-binding domain protein,T,67,15,5.12133E-23
COG0589,Universal stress protein,T,84,15,5.12111E-23
NOG102852,[NoAnn],S,77,16,4.21197E-23
NOG93231,[NoAnn],S,89,16,4.16778E-23
NOG62895,conserved protein,S,119,17,4.09784E-23
COG3649,CRISPR-Associated Protein,L,161,16,3.76644E-23
COG3236,Swarming motility protein YbiA,S,174,17,2.03786E-23
NOG23437,[NoAnn],S,92,17,2.0368E-23
COG3326,Cold-shock dna-binding domain protein,S,104,16,1.98954E-23
NOG49422,(ABC) transporter,R,83,16,1.8456E-23
COG3503,Membrane,S,95,18,1.79096E-23
COG0131,imidazoleglycerolphosphate dehydratase,E,146,18,1.36493E-23
COG0393,UPF0145 protein,S,85,16,1.2768E-23
NOG03795,AlwI restriction endonuclease,V,111,16,1.06584E-23
COG0605,Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity),P,68,17,1.05889E-23
COG4577,Microcompartments protein,E,131,16,7.3437E-24
COG0404,The glycine cleavage system catalyzes the degradation of glycine (By similarity),E,117,17,7.20347E-24
NOG84824,Protein of unknown function (DUF402),S,32,16,6.6191E-24
NOG07759,Short-chain dehydrogenase reductase Sdr,R,141,17,6.55268E-24
NOG68725,prevent-host-death family,D,107,16,6.50965E-24
COG0835,chew protein,N,119,16,6.19556E-24
NOG01321,ADP-ribosylation Crystallin J1,S,122,18,6.18802E-24
COG2501,s4 domain protein,S,123,16,5.91477E-24
NOG62814,"Addiction module antitoxin, RelB DinJ family",S,33,16,5.87972E-24
NOG85631,conserved protein (some members contain a von Willebrand factor type A (vWA) domain),S,74,16,5.53629E-24
COG0083,Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity),E,91,16,5.19421E-24
NOG01615,[NoAnn],S,101,16,5.18686E-24
COG1468,crispr-associated protein cas4,L,138,16,4.89148E-24
COG3940,Alpha-N-arabinofuranosidase,G,84,16,4.82301E-24
NOG64445,methyltransferase Fkbm family,R,124,16,4.63961E-24
COG1319,Dehydrogenase,C,116,16,4.43584E-24
COG1232,protoporphyrinogen oxidase,H,126,16,4.40492E-24
COG3853,Toxic anion resistance,P,152,16,4.18082E-24
NOG51410,[NoAnn],S,122,16,4.07221E-24
NOG08927,[NoAnn],S,117,16,3.92536E-24
NOG83096,[NoAnn],S,64,16,3.90045E-24
COG1672,ATPase (AAA,R,153,16,3.83924E-24
COG1807,"glycosyl transferase, family 39",M,85,16,3.7719E-24
COG3359,Exonuclease-like protein,L,89,16,3.64386E-24
NOG72582,NlpC P60 family protein,S,79,16,3.55441E-24
COG0385,bile acid,R,105,17,3.30136E-24
NOG06087,phage protein,R,94,16,3.29126E-24
NOG30614,restriction enzyme,V,93,16,3.16843E-24
COG1448,aminotransferase,E,55,16,3.16697E-24
NOG49649,Pfam:DUF1393,S,58,16,3.09353E-24
NOG54445,Phage Portal Protein,R,117,16,2.98357E-24
COG4767,Vanz family,V,168,17,2.93214E-24
COG2425,VWA domain protein interacting with AAA ATPase,R,86,16,2.84518E-24
COG3201,Nicotinamide Mononucleotide Transporter,H,157,16,2.81989E-24
COG0279,Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity),G,146,16,2.80774E-24
COG1152,"Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2) (By similarity)",C,39,16,2.74828E-24
COG1614,"Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2) (By similarity)",C,39,16,2.74828E-24
NOG65081,S-layer homology domain,S,48,16,2.72466E-24
COG0176,Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity),G,165,16,2.69155E-24
COG4552,#NAME?,R,117,16,2.64076E-24
NOG39196,sporulation protein YtxC,S,52,16,2.54162E-24
NOG54390,[NoAnn],S,93,16,2.52512E-24
NOG64076,"extracellular solute-binding protein, family 1",G,72,16,2.42501E-24
COG0303,Molybdenum cofactor synthesis domain protein,H,135,17,2.39122E-24
COG4677,pectinesterase,G,77,16,2.34735E-24
NOG36500,[NoAnn],S,83,16,2.33115E-24
NOG67933,[NoAnn],S,102,16,2.30947E-24
NOG10701,Phage plasmid-related protein TIGR03299,S,111,16,2.30298E-24
COG5520,hydrolase family 30,G,103,16,2.27931E-24
NOG26213,[NoAnn],S,194,16,2.26754E-24
COG1648,Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity),H,95,16,2.24204E-24
NOG81842,HNH endonuclease,V,119,18,2.04874E-24
NOG63378,[NoAnn],S,88,17,1.87492E-24
NOG79143,[NoAnn],S,124,18,1.86978E-24
NOG69173,RNA polymerase sigma-24 subunit ECF subfamily,K,170,18,1.58255E-24
COG2379,hydroxypyruvate reductase,G,93,17,1.32391E-24
NOG216085,DNA-binding helix-turn-helix protein,S,108,17,1.32349E-24
NOG19820,Domain of unknown function (DUF2828),S,130,17,9.05425E-25
COG0757,Catalyzes a trans-dehydration via an enolate intermediate (By similarity),E,146,17,7.54453E-25
COG0712,"F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)",C,166,19,6.62997E-25
COG0311,Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity),H,68,17,6.4997E-25
NOG00412,Polysaccharide biosynthesis protein,M,150,17,6.08214E-25
NOG32219,Negative regulator of genetic competence,R,121,18,5.85505E-25
COG1629,receptor,P,103,18,5.43226E-25
NOG01935,"kila-n, DNA-binding domain",S,131,18,4.9304E-25
NOG213373,regulatory protein,S,116,17,4.76061E-25
NOG16650,[NoAnn],S,120,17,4.34538E-25
COG1600,"Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)",C,104,17,3.60069E-25
COG4856,ybbr family,S,165,17,3.45545E-25
COG1155,Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity),C,202,17,3.33861E-25
COG1292,Transporter,P,115,17,3.25537E-25
NOG01763,[NoAnn],S,105,17,3.17963E-25
COG3774,glycosyltransferase,M,158,17,3.09909E-25
COG5652,vanz family,S,161,17,2.83442E-25
COG2816,NADH pyrophosphatase,L,166,18,2.45885E-25
NOG76733,[NoAnn],S,64,17,2.35186E-25
NOG18967,type II restriction endonuclease,V,121,17,2.33201E-25
NOG84127,prevent-host-death family,S,104,17,2.3148E-25
NOG28624,[NoAnn],S,57,17,1.69989E-25
NOG07240,[NoAnn],S,76,17,1.69423E-25
COG0711,"F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)",C,157,18,1.66834E-25
COG2135,conserved protein,S,102,17,1.65815E-25
NOG41926,type ii secretion system,U,93,17,1.65036E-25
NOG03471,[NoAnn],S,101,17,1.6364E-25
COG0160,aminotransferase,E,117,17,1.62772E-25
COG4206,tonB-dependent Receptor,P,113,17,1.52264E-25
COG2860,Membrane,S,139,17,1.49532E-25
NOG94426,signal transduction histidine kinase regulating citrate malate metabolism,T,62,17,1.47042E-25
NOG30962,VTC domain,S,122,19,1.45713E-25
COG4657,Electron transport complex,C,187,20,1.36132E-25
NOG105941,Domain of Unknown Function (DUF1599),S,74,17,1.34963E-25
COG1827,domain protein,K,134,17,1.33427E-25
COG0801,2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase,H,112,17,1.30757E-25
NOG213154,[NoAnn],S,157,17,1.29911E-25
NOG34644,[NoAnn],S,168,17,1.29694E-25
NOG09836,Protein of unknown function (DUF3737) ,S,95,17,1.29205E-25
COG0721,Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity),J,192,17,1.27675E-25
NOG12422,Protein of unknown function (DUF2899),S,220,18,1.27423E-25
COG0373,Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity),H,82,17,1.15849E-25
COG4928,p-loop domain protein,R,158,17,1.15476E-25
NOG83641,Transcriptional regulator,K,142,17,1.15355E-25
NOG40345,Transcriptional regulator,K,136,17,1.14088E-25
COG0760,peptidyl-prolyl cis-trans isomerase,O,130,17,1.11931E-25
NOG48759,peptidase M23,S,112,17,1.1136E-25
NOG211904,[NoAnn],S,122,17,1.08974E-25
COG0179,Fumarylacetoacetate hydrolase,Q,117,17,1.08879E-25
NOG52751,[NoAnn],S,105,17,1.0699E-25
COG1564,thiamine pyrophosphokinase,H,207,23,1.0377E-25
COG4226,hicB family,S,89,17,1.01241E-25
COG0156,8-Amino-7-oxononanoate synthase,H,63,17,9.87207E-26
COG1089,"GDP-mannose 4,6-dehydratase",M,92,17,9.63125E-26
COG3808,pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for,C,163,20,6.9268E-26
COG3472,Pfam:DUF2081,S,111,19,6.60864E-26
NOG35658,[NoAnn],S,99,20,6.23296E-26
COG0181,Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity),H,96,18,5.78038E-26
NOG10411,[NoAnn],S,82,18,5.7627E-26
COG0824,Thioesterase,R,140,18,5.6198E-26
COG1862,"preprotein translocase, subunit YajC",U,131,18,4.88634E-26
COG0475,Sodium hydrogen exchanger,P,194,19,3.54089E-26
COG4225,Glycosyl Hydrolase Family 88,R,132,18,2.75295E-26
NOG212222,glycosyltransferase,M,132,19,2.54077E-26
NOG137619,Reverse transcriptase (RNA-dependent DNA polymerase),S,90,18,2.50444E-26
COG1528,ferritin,P,94,18,2.27029E-26
COG2964,YheO domain protein,S,188,18,2.2023E-26
COG0705,rhomboid family,R,150,19,2.0009E-26
NOG23596,"Glycosyl transferase, family 2",M,79,18,1.97585E-26
COG0029,L-aspartate oxidase,H,120,18,1.82658E-26
NOG80563,"Toxin-antitoxin system, toxin component, RelE family",S,94,18,1.78885E-26
COG3880,UvrB UvrC protein,S,140,21,1.77003E-26
NOG02120,"Phage terminase, large subunit",R,104,24,1.55768E-26
COG1315,PALM domain HD hydrolase domain and,L,82,19,1.55119E-26
NOG79162,[NoAnn],S,198,18,1.41927E-26
COG1512,of methanol dehydrogenase type,S,131,19,1.33055E-26
NOG51107,acetyltransferase,R,116,18,1.32159E-26
COG0255,50s ribosomal protein l29,J,223,18,1.16922E-26
COG3010,Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity),G,93,18,1.10475E-26
COG1705,flagellar rod assembly protein muramidase flgj,N,193,18,1.05215E-26
COG2272,Carboxylesterase,I,124,18,1.01299E-26
COG3949,Membrane,S,113,18,9.71753E-27
NOG213389,[NoAnn],S,91,18,9.23092E-27
COG0521,molybdenum cofactor biosynthesis protein,H,101,20,8.70578E-27
COG1525,nuclease,L,98,19,8.21776E-27
COG2376,Dihydroxyacetone kinase,G,154,18,7.94793E-27
COG1668,(ABC) transporter,C,147,18,7.72803E-27
NOG83503,prevent-host-death family,S,117,18,7.64407E-27
NOG21823,"transcriptional regulator, AraC family",K,159,22,7.04532E-27
NOG35078,vitamin B12 dependent methionine synthase activation,S,133,26,6.68541E-27
COG4806,l-rhamnose isomerase,G,153,19,6.34608E-27
NOG48617,Histidine kinase,T,92,18,6.24306E-27
NOG11476,inner membrane protein DUF1819,S,94,20,6.22765E-27
COG1357,Pentapeptide repeat protein,S,118,18,6.17114E-27
NOG64509,[NoAnn],S,92,18,5.75242E-27
COG0677,Dehydrogenase,M,118,18,5.71662E-27
NOG02363,Glycosyl transferase (Group 1,M,165,21,5.65315E-27
COG1457,"permease for cytosine purines, uracil, thiamine, allantoin",F,120,18,5.57792E-27
COG4732,thiw protein,S,125,18,5.40865E-27
NOG32535,DNA primase,L,161,19,5.32175E-27
COG2182,"extracellular solute-binding protein, family 1",G,152,18,4.93779E-27
NOG50189,[NoAnn],S,184,18,4.73253E-27
COG0355,Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity),C,142,18,4.65834E-27
NOG55583,Aminoglycoside phosphotransferase,R,122,19,4.64755E-27
COG2013,conserved protein,S,194,18,4.46217E-27
NOG62935,[NoAnn],S,85,18,4.46206E-27
NOG65065,[NoAnn],S,125,18,4.44142E-27
COG4690,dipeptidase,E,110,19,3.33913E-27
COG5011,radical SAM domain protein,S,176,19,2.40713E-27
COG0764,Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity),I,193,19,2.25722E-27
COG1343,"CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)",L,161,19,1.55605E-27
COG0224,Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity),C,231,21,1.4713E-27
COG1171,Threonine dehydratase,E,289,35,1.33728E-27
NOG212813,major facilitator superfamily,G,138,19,9.76476E-28
COG2222,Isomerase,M,140,19,9.61324E-28
COG1266,caax amino terminal protease family protein,R,153,19,9.19787E-28
COG3225,transport system,N,145,19,8.98072E-28
COG3584,domain protein,S,140,19,7.645E-28
COG1394,Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity),C,159,19,7.57423E-28
COG4750,cytidylyltransferase choline kinase,M,149,19,5.55534E-28
COG2855,Membrane,S,128,19,5.23827E-28
NOG08146,transcriptional Regulator LysR family,K,133,19,5.116E-28
COG0709,Synthesizes selenophosphate from selenide and ATP (By similarity),E,88,21,4.9008E-28
NOG39150,[NoAnn],S,96,20,4.82178E-28
COG0241,"D,d-heptose 1,7-bisphosphate phosphatase",E,134,19,4.52126E-28
COG0075,aminotransferase,E,148,19,4.49788E-28
NOG01717,(ABC) transporter,R,144,19,4.42785E-28
COG3867,"arabinogalactan endo-1,4-beta-galactosidase",G,122,19,4.42334E-28
COG1346,lrgb family,M,129,19,4.17891E-28
COG0710,Type I DHQase,E,167,19,3.99788E-28
COG3654,Death-On-Curing Family,S,136,19,3.91432E-28
COG0777,Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity),I,140,19,3.84169E-28
NOG61803,Thioredoxin,O,184,19,3.83919E-28
NOG61897,"transcriptional regulator, merr family",K,97,19,3.65668E-28
COG4585,Histidine kinase,T,102,20,3.64077E-28
NOG53640,Pfam:DUF1393,S,142,19,3.51944E-28
COG2082,Precorrin-8x methylmutase,H,92,21,3.34489E-28
COG1508,Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity),K,115,19,3.28976E-28
NOG07823,[NoAnn],R,41,19,3.25972E-28
NOG61825,[NoAnn],S,229,19,3.10346E-28
COG1358,(ribosomal) protein,J,151,19,3.07909E-28
NOG13353,LysR family transcriptional Regulator,K,121,19,3.01339E-28
NOG51462,acetyltransferase,R,140,19,2.98002E-28
COG3221,"phosphonate ABC transporter, periplasmic phosphonate-binding protein",P,90,19,2.96622E-28
COG4185,Zeta toxin,S,103,19,2.85629E-28
COG4666,"trap transporter, 4tm 12tm fusion protein",R,159,19,2.71121E-28
NOG40008,tetratricopeptide repeat protein,S,123,20,2.70387E-28
NOG40214,[NoAnn],S,152,19,2.66659E-28
NOG79141,"Transcriptional regulator, padR family",K,79,19,2.63265E-28
NOG214920,Stress responsive A B Barrel Domain,S,69,19,2.46895E-28
COG2221,sulfite reductase,C,88,19,2.4468E-28
NOG36258,Sporulation transcription factor Spo0A,T,137,24,2.42661E-28
COG0847,DNA polymerase iii,L,126,19,2.34715E-28
COG4465,DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity),K,145,19,2.34621E-28
NOG02914,Binding-protein-dependent transport systems inner membrane component,P,105,19,2.24693E-28
NOG01210,[NoAnn],S,92,22,2.19843E-28
NOG55985,family Transcriptional regulator,K,83,19,2.15259E-28
COG1455,pts system,G,130,19,2.11657E-28
COG1350,The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity),E,161,19,2.07789E-28
NOG33040,[NoAnn],S,149,19,2.06549E-28
COG3299,baseplate J family protein,S,204,19,2.01274E-28
COG1787,restriction endonuclease,V,144,21,1.90171E-28
COG5017,glycosyltransferase,S,120,20,1.67119E-28
NOG85507,"Phage tail tape measure protein, TP901 family",S,203,21,1.58565E-28
NOG30065,Pfam:DUF1393,S,75,20,1.5034E-28
COG3093,Plasmid maintenance system antidote protein,R,101,22,1.14254E-28
COG1083,cytidylyltransferase,M,119,20,1.05933E-28
COG3070,TfoX domain-containing protein,K,164,20,9.62364E-29
COG0139,Phosphoribosyl-amp cyclohydrolase,E,163,21,6.79636E-29
NOG25570,[NoAnn],S,171,20,6.45233E-29
NOG214556,[NoAnn],S,113,20,5.56804E-29
NOG122687,DNA polymerase,L,106,20,5.41027E-29
NOG03393,"CobW HypB UreG, nucleotide-binding domain",S,216,20,5.34315E-29
COG3870,protein from nitrogen regulatory protein P-II,S,159,20,4.47896E-29
COG3395,"type III effector, Hrp-dependent",S,130,21,3.23152E-29
NOG14745,[NoAnn],S,147,20,3.0513E-29
COG0312,peptidase U62 modulator of DNA gyrase,R,200,26,2.97452E-29
COG0107,"IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)",E,217,21,2.90827E-29
COG1342,UPF0251 protein,S,202,20,2.89141E-29
COG5542,Phosphatidylinositol glycan anchor biosynthesis class V,S,111,20,2.84116E-29
NOG48409,Sporulation protein YyaC,S,130,20,2.41675E-29
NOG29898,PT repeat-containing protein,S,170,22,2.18426E-29
COG3212,Peptidase propeptide and YpeB domain protein,S,206,20,2.1583E-29
COG1345,flagellar hook-associated,N,124,39,1.97668E-29
NOG06282,Sodium hydrogen exchanger,P,167,20,1.88999E-29
NOG04940,germination protein ypeb,S,162,20,1.75342E-29
COG0736,Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity),I,131,20,1.73749E-29
COG2721,Dehydratase,G,191,20,1.73394E-29
NOG20326,DNA-binding helix-turn-helix protein,K,247,20,1.71731E-29
NOG28552,PhosPhorylase,S,115,21,1.64836E-29
NOG179868,nhl repeat containing protein,S,100,21,1.61725E-29
NOG53073,"acetyltransferase, (GNAT) family",R,133,20,1.58662E-29
NOG05877,conserved protein UCP033563,S,180,25,1.42061E-29
COG3444,pts system,G,145,20,1.34223E-29
NOG91007,[NoAnn],S,136,30,1.23386E-29
COG1288,c4-dicarboxylate anaerobic carrier,S,175,20,1.17553E-29
COG2050,thioesterase Superfamily protein,Q,97,20,1.12182E-29
COG5519,membrane,L,100,20,1.11093E-29
NOG04249,[NoAnn],S,174,20,1.06303E-29
COG2000,domain protein,S,156,20,1.04202E-29
COG0476,UBA THIF-type NAD FAD binding protein,H,137,20,9.54224E-30
COG1256,flagellar hook-associated protein,N,116,20,8.29366E-30
COG3315,Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity),Q,185,20,8.19533E-30
COG4894,Pfam:DUF567,S,123,20,7.8288E-30
NOG57754,protein conserved in bacteria,S,130,20,7.82055E-30
NOG79062,iron-only hydrogenase system regulator,S,198,24,6.49093E-30
NOG05945,glycosyl transferase group 1,M,120,21,5.42346E-30
COG4268,5-methylcytosine restriction system,V,103,23,5.36075E-30
NOG66794,C_GCAxxG_C_C family,S,139,21,3.66961E-30
NOG79879,[NoAnn],S,132,21,3.4033E-30
COG3956,MazG family,R,173,23,3.25973E-30
NOG28639,Phage terminase small subunit,S,110,28,2.85196E-30
COG4115,"Addiction module toxin, Txe YoeB family",S,158,21,2.71815E-30
NOG44049,"Toxin-antitoxin system, antitoxin component, HicB family",S,86,21,2.47381E-30
COG2893,pts system,G,114,21,2.32278E-30
COG0450,alkyl hydroperoxide reductase,O,140,21,2.28786E-30
COG4570,"Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity)",L,162,22,2.14074E-30
COG3022,UPF0246 protein,S,96,23,1.6969E-30
COG0849,This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity),D,212,21,1.51958E-30
COG1205,DEAD DEAH box helicase,L,115,21,1.51635E-30
COG0001,Glutamate-1-semialdehyde aminotransferase,H,94,21,1.4908E-30
COG0309,Hydrogenase expression formation protein HypE,O,125,21,1.41579E-30
NOG78981,Transcriptional regulator GntR family,K,101,21,1.39038E-30
NOG86162,[NoAnn],S,96,21,1.28853E-30
COG1878,Cyclase family,R,169,21,1.26735E-30
NOG26788,5-bromo-4-chloroindolyl phosphate hydrolysis protein,S,158,22,1.14888E-30
NOG54858,[NoAnn],S,99,21,1.08709E-30
NOG03985,(ABC) transporter,R,129,21,1.01738E-30
COG0227,50s ribosomal protein L28,J,157,21,9.38402E-31
NOG54177,[NoAnn],S,140,21,9.16714E-31
NOG05249,S-layer protein,S,124,21,8.79831E-31
COG0842,(ABC) transporter,V,196,23,8.78331E-31
COG0147,synthase (Component I),E,194,21,8.57022E-31
NOG67268,[NoAnn],S,95,21,8.25285E-31
COG2978,Transporter,H,116,21,8.0268E-31
COG0198,One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity),J,347,21,7.84883E-31
NOG70388,[NoAnn],S,248,21,7.24174E-31
COG4870,cysteine,O,170,26,7.23642E-31
COG1304,"Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)",C,150,23,7.23462E-31
NOG03182,Sulfite exporter TauE/SafE,S,146,21,6.96211E-31
NOG05192,relaxase Mobilization nuclease domain protein,S,154,21,6.78605E-31
NOG18896,[NoAnn],S,96,21,6.77994E-31
NOG01512,alpha-galactosidase,G,112,21,6.7137E-31
COG3715,PTS System,G,162,21,6.31583E-31
COG4988,(ABC) transporter,V,166,21,6.06123E-31
COG3754,biosynthesis protein,M,133,21,6.02357E-31
NOG50824,cell division septal protein,S,68,24,5.94415E-31
NOG15520,[NoAnn],S,138,21,5.88586E-31
NOG78886,Stage III sporulation protein AC,S,152,21,5.83008E-31
COG2818,Dna-3-methyladenine glycosylase i,L,207,21,5.77782E-31
NOG10211,Pectate lyase,S,92,21,5.5461E-31
NOG03194,[NoAnn],S,141,22,5.41002E-31
COG1329,Transcriptional regulator (CarD family,K,154,22,5.23613E-31
COG3394,UPF0249 protein,S,85,21,4.99019E-31
NOG54730,[NoAnn],S,89,21,4.57178E-31
COG5281,Tape measure protein,S,155,21,4.54705E-31
NOG14877,Type II restriction,V,136,21,4.37598E-31
NOG00128,[NoAnn],S,131,22,3.72869E-31
NOG83571,Branched-chain amino acid transport,E,102,21,3.62201E-31
COG2382,esterase,P,100,21,3.50603E-31
NOG05341,[NoAnn],S,158,21,3.50079E-31
COG2137,Modulates RecA activity (By similarity),R,149,21,3.40608E-31
COG3973,Helicase,L,182,23,3.02419E-31
NOG79164,[NoAnn],S,176,24,2.74883E-31
COG0307,"riboflavin synthase, subunit alpha",H,114,22,2.20088E-31
COG4832,Pfam:DUF2174,S,182,23,2.06794E-31
COG0333,50s ribosomal protein l32,J,189,24,1.98692E-31
NOG28713,Portal protein,S,133,27,1.67057E-31
COG2827,Excinuclease abc c subunit domain protein,L,144,22,1.65315E-31
NOG09200,"Transposase, IS605 OrfB family",L,119,22,1.53509E-31
NOG55366,ParB-like nuclease domain,S,132,24,1.48133E-31
COG3639,Phosphonate ABC transporter,P,118,23,1.44203E-31
NOG01601,Membrane,S,201,22,1.43432E-31
COG4978,Transcriptional regulator,K,120,22,1.17205E-31
NOG33323,Histidine kinase,T,133,24,1.09235E-31
COG0106,phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase,E,153,24,1.07724E-31
COG2706,6-phosphogluconolactonase,G,107,22,8.04972E-32
COG3587,type IIi,V,227,22,6.73748E-32
NOG00479,(ABC) transporter,P,142,23,6.46665E-32
NOG02716,(ABC) transporter,E,217,22,5.87746E-32
COG0331,Malonyl coA-acyl carrier protein transacylase,I,215,22,4.63537E-32
NOG02111,"Glycosyl transferase, family 2",M,148,24,4.42904E-32
NOG39491,response regulator,T,141,22,4.37455E-32
NOG50857,[NoAnn],S,161,22,4.30538E-32
NOG38874,Phage major capsid protein,S,151,22,4.29192E-32
NOG01415,amino acid adenylation,Q,104,22,4.10814E-32
NOG16083,[NoAnn],S,52,22,3.58634E-32
NOG00826,Major Facilitator,G,148,26,3.43347E-32
COG0294,dihydropteroate synthase,H,125,22,3.35632E-32
COG2359,stage V sporulation protein S,S,156,22,3.12874E-32
COG3866,Pectate lyase,G,106,22,3.1281E-32
COG4786,flagellar basal-body rod protein,N,159,22,2.99501E-32
COG3410,Uncharacterized conserved protein (DUF2075),S,93,22,2.9148E-32
COG3681,UPF0597 protein,S,218,27,2.89676E-32
COG2878,Electron transport complex,C,191,25,2.79507E-32
COG2378,Transcriptional regulator,K,205,27,2.77981E-32
COG1183,Cdp-diacylglycerol--serine o-phosphatidyltransferase,I,104,25,2.6062E-32
COG0379,Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity),H,148,22,2.31107E-32
NOG83257,[NoAnn],S,96,22,2.05075E-32
NOG82300,Phage minor structural protein GP20,S,101,22,2.04523E-32
COG2116,Formate nitrite transporter,P,164,22,2.01399E-32
COG0064,Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity),J,245,22,2.00694E-32
COG1687,Branched-chain amino acid,E,158,22,1.99233E-32
NOG13151,regulator,T,222,23,1.96547E-32
COG1249,dihydrolipoyl dehydrogenase,C,164,22,1.91449E-32
COG3426,Branched-chain carboxylic acid kinase,C,142,22,1.91269E-32
COG1274,"Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)",C,128,22,1.78285E-32
NOG04320,Two component transcriptional regulator (Winged helix family,T,210,22,1.69089E-32
COG5280,"Phage tail tape measure protein, TP901 family",S,282,22,1.62589E-32
NOG97624,[NoAnn],S,68,22,1.46964E-32
COG0038,chloride channel,P,248,31,1.28662E-32
NOG30696,[NoAnn],U,127,24,1.19354E-32
NOG01925,Domain of unknown function (DUF1848),S,240,23,9.78679E-33
COG1610,gatB Yqey,S,228,23,8.92573E-33
COG0549,carbamate kinase,E,189,23,7.30747E-33
COG1762,PTS System,G,297,23,4.79299E-33
COG3476,tspo and mbr like protein,T,136,24,4.65384E-33
COG3103,domain protein,T,173,23,4.59689E-33
NOG86251,[NoAnn],K,105,23,4.17076E-33
COG0785,Cytochrome c biogenesis protein,O,127,23,4.08547E-33
NOG12085,glycosyltransferase,S,140,23,4.00448E-33
COG2052,UPF0296 protein,S,200,23,3.96202E-33
COG3894,Ferredoxin,C,153,23,3.88127E-33
NOG38416,(ABC) transporter,R,95,24,3.55646E-33
COG1589,"Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)",M,83,23,3.22403E-33
COG0850,Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity),D,114,24,3.03249E-33
COG0093,Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity),J,357,23,2.8546E-33
COG4653,Phage major capsid protein,R,137,23,2.58248E-33
NOG35993,DNA-binding helix-turn-helix protein,S,209,23,2.46626E-33
COG1975,xanthine dehydrogenase,O,209,24,2.20277E-33
COG2091,4'-phosphopantetheinyl transferase,H,161,25,1.91129E-33
COG3638,(ABC) transporter,P,93,24,1.7488E-33
NOG70658,"Site-specific recombinases, DNA invertase Pin homologs",L,175,23,1.7377E-33
NOG33428,Ser Thr phosphatase family protein,R,142,23,1.59062E-33
NOG21898,"sigma-70, region 4",S,148,23,1.58544E-33
NOG46872,Filamentation induced by cAMP protein fic,S,128,24,1.58076E-33
COG0662,Mannose-1-phosphate guanylyltransferase Mannose-6-phosphate isomerase,G,201,24,1.56313E-33
NOG03950,Diguanylate cyclase,T,185,29,1.5322E-33
NOG00860,Phage Portal Protein,R,158,23,1.36035E-33
NOG27834,"Transcriptional regulator, ARAC family",K,117,23,1.3321E-33
NOG63203,Stage iii sporulation protein ad,S,178,23,1.21285E-33
COG1237,beta-lactamase domain protein,R,104,23,1.20092E-33
COG2605,Ghmp kinase,R,166,23,1.18022E-33
COG0021,Transketolase,G,185,23,1.17945E-33
COG0054,"Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)",H,101,23,1.04843E-33
NOG01474,[NoAnn],S,148,23,9.32428E-34
COG1438,Regulates arginine biosynthesis genes (By similarity),K,193,25,9.25406E-34
COG1114,branched-chain amino acid transport system II carrier protein,E,173,23,9.07133E-34
COG2996,S1 RNA binding domain protein,S,118,23,8.49463E-34
NOG01731,[NoAnn],S,110,24,7.37197E-34
NOG01922,prophage antirepressor,S,201,23,6.80163E-34
COG5434,Glycoside hydrolase family 28,M,160,25,5.54775E-34
COG4124,"mannan endO-1,4-beta-mannosidase",G,122,25,5.15426E-34
COG1189,hemolysin a,J,188,24,4.78056E-34
COG1108,ABC transporter,P,210,26,3.95723E-34
COG3331,"Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)",R,149,24,3.87575E-34
COG1486,glycoside hydrolase family 4,G,181,25,3.67495E-34
COG0135,N-(5'-phosphoribosyl)anthranilate isomerase,E,124,24,3.54856E-34
COG3740,"Phage prohead protease, HK97 family",R,133,26,2.79567E-34
COG1247,N-acetyltransferase,M,270,24,2.69817E-34
COG0108,"Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)",H,95,24,2.47155E-34
COG0807,"Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)",H,94,24,2.47155E-34
COG3119,Sulfatase,P,187,24,2.12261E-34
NOG21616,"Uncharacterised ACR, YkgG family COG1556",S,238,24,1.8953E-34
COG4822,cobalt chelatase,H,198,27,1.67821E-34
NOG14127,Serine Threonine protein kinase,T,157,24,1.63148E-34
NOG03681,(LipO)protein,S,156,24,1.56619E-34
COG5002,Histidine kinase,T,161,26,1.46821E-34
NOG01697,transposase,L,196,24,1.28244E-34
COG1720,family UPF0066,S,230,26,1.06629E-34
COG5184,regulator of chromosome condensation,D,160,24,8.7753E-35
COG0095,"Lipoate-protein, ligase",H,167,24,7.76397E-35
COG0066,"Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)",E,204,24,7.5407E-35
NOG101572,CAAX amino terminal protease family,R,205,28,7.34942E-35
COG4586,(ABC) transporter,R,111,24,6.88387E-35
COG4506,Domain of unknown function (DUF1934),S,130,24,6.67814E-35
COG2273,Glycoside hydrolase family 16,G,125,24,6.03281E-35
COG1322,Dna recombination protein,S,129,26,5.73397E-35
NOG61989,[NoAnn],S,137,24,5.57123E-35
COG2065,Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity),F,132,24,5.47201E-35
NOG03567,biosynthesis protein,S,149,24,5.20368E-35
NOG82897,[NoAnn],S,202,24,5.14462E-35
COG3270,Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA (By similarity),J,151,24,4.58499E-35
COG3706,Diguanylate cyclase,T,123,25,4.54295E-35
COG4973,"Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)",L,103,24,4.07183E-35
COG4152,(ABC) transporter,R,132,24,3.85323E-35
COG3468,Outer membrane autotransporter,M,228,24,3.28369E-35
NOG19646,[NoAnn],S,252,32,2.09331E-35
NOG08452,Protein of unknown function (DUF2974),S,186,25,2.03379E-35
NOG47429,[NoAnn],S,167,25,1.41612E-35
NOG05292,"acetyltransferase, (GNAT) family",R,154,25,1.2218E-35
NOG83038,Transcriptional regulator,K,141,25,1.22159E-35
COG2008,Aldolase,E,227,25,1.21724E-35
COG0222,Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity),J,332,25,1.09764E-35
COG3464,transposase,L,174,25,9.71783E-36
NOG52808,[NoAnn],S,199,25,8.51151E-36
COG4805,secreted protein,S,130,25,8.14384E-36
COG3910,Aaa atpase,R,192,26,6.65817E-36
NOG103690,[NoAnn],S,222,25,5.67302E-36
NOG66915,[NoAnn],S,135,25,5.64308E-36
COG1194,a g-specific adenine glycosylase,L,254,28,5.64172E-36
COG0457,repeat-containing protein,R,207,25,5.56049E-36
COG2006,iron-sulfur cluster-binding protein,S,131,25,5.0376E-36
COG4422,gp37gp68 family,S,195,25,4.79885E-36
NOG20032,FliB family,S,187,25,4.56321E-36
COG3981,acetyltransferase,R,145,26,4.40597E-36
NOG212870,"Site-specific recombinase, phage integrase family",L,184,25,4.39451E-36
NOG29906,Transcriptional regulator,K,107,25,4.249E-36
COG1598,"Toxin-antitoxin system, antitoxin component, HicB family",S,151,25,4.15742E-36
COG5009,penicillin-binding protein 1A,M,125,25,3.92406E-36
NOG53115,integral membrane protein,S,166,25,3.91376E-36
COG1243,Histone acetyltransferase,B,142,25,3.82978E-36
COG1611,decarboxylase,S,170,25,3.553E-36
COG4475,UPF0340 protein,S,136,25,3.18959E-36
NOG72933,Siphovirus protein of unknown function (DUF859),S,149,25,3.06786E-36
NOG68408,Transcriptional regulator,K,136,25,2.77345E-36
COG1660,Displays ATPase and GTPase activities (By similarity),R,229,27,2.74972E-36
COG1752,K07001 NTE family protein,R,193,25,2.32531E-36
COG4826,"Serpin peptidase inhibitor, clade",O,228,29,2.28987E-36
COG2710,Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity),C,131,25,2.28713E-36
NOG03535,Abortive infection protein AbiGII,S,195,25,1.94775E-36
COG2247,Cell wall binding repeat 2-containing protein,M,143,25,1.87322E-36
NOG47864,surface cell-adhesion protein,S,332,25,1.84543E-36
COG1716,fha domain-containing protein,T,71,25,1.74548E-36
NOG04466,[NoAnn],S,236,27,1.73574E-36
COG4286,UPF0160 protein,S,78,25,1.72924E-36
COG0626,cystathionine,E,127,26,1.6013E-36
NOG03559,Filamentation induced by cAMP protein fic,S,122,25,1.56152E-36
NOG70174,[NoAnn],S,120,25,1.53979E-36
COG4641,Spore maturation protein,S,185,27,1.37192E-36
NOG43719,"Site-specific recombinase, phage integrase family",L,181,26,1.1346E-36
COG2109,"Cob-I-yrinic acid a,c-diamide adenosyltransferase",H,223,26,7.14888E-37
COG3875,Domain of unknown function (DUF2088),S,226,30,6.52909E-37
COG0141,Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity),E,154,26,6.37412E-37
NOG66355,Protein of unknown function (DUF1113),S,188,26,5.79869E-37
COG0214,"Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)",H,112,26,4.49199E-37
NOG11449,Cobalt transport protein,P,201,26,3.75848E-37
COG1432,conserved protein,S,185,26,3.51395E-37
COG0410,(ABC) transporter,E,216,26,3.30749E-37
COG4536,CBS Domain protein,P,177,26,3.13948E-37
COG0094,"This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits",J,357,26,2.54942E-37
COG0327,"dinuclear metal center protein, YbgI",S,265,31,2.30718E-37
NOG20609,transposase,L,100,26,2.23295E-37
COG4912,DNA alkylation repair enzyme,L,238,27,1.78214E-37
COG1692,metallophosphoesterase,S,201,26,1.71455E-37
COG2805,twitching motility protein,N,189,26,1.62064E-37
COG0398,Snare associated golgi protein,S,192,30,1.59178E-37
COG1098,RNA binding s1 domain protein,J,239,26,1.5397E-37
COG1123,(ABC) transporter,R,119,26,1.47919E-37
COG3594,Acyltransferase,G,144,26,1.36858E-37
COG1625,oxidoreductase,C,242,27,1.3022E-37
COG2038,"Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)",H,120,26,1.20524E-37
COG0310,Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity),P,77,26,1.16958E-37
NOG50107,HD Domain,R,176,26,1.12129E-37
COG5523,integral membrane protein,S,203,26,1.05116E-37
COG0118,"IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to hisF for the synthesis of IGP and AICAR (By similarity)",E,178,27,1.0432E-37
COG1178,ABC transporter (permease),P,249,26,9.3874E-38
NOG33980,[NoAnn],S,316,26,9.12925E-38
COG2080,(2Fe-2S)-binding domain protein,C,257,28,8.97886E-38
COG2145,4-methyl-5-beta-hydroxyethylthiazole kinase,H,204,29,8.73006E-38
COG0627,esterase,R,136,26,8.36578E-38
NOG49459,[NoAnn],S,159,26,7.39587E-38
COG3635,Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity),G,142,29,7.22898E-38
COG3600,Phage-Associated Protein,S,174,26,6.90115E-38
NOG02117,[NoAnn],S,150,26,5.23911E-38
COG0511,"Acetyl-CoA carboxylase, biotin carboxyl carrier protein",I,269,28,5.1198E-38
NOG00279,Histidine kinase,T,211,29,4.92834E-38
COG2089,synthase,M,131,27,4.64367E-38
COG4771,receptor,P,170,28,4.31045E-38
NOG04676,Regulator,T,186,33,3.30256E-38
COG1305,transglutaminase domain-containing protein,E,182,27,3.06273E-38
NOG01611,alpha-l-fucosidase,S,132,27,2.89947E-38
COG0704,Plays a role in the regulation of phosphate uptake,P,224,27,2.65341E-38
COG0743,Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity),I,296,29,2.47419E-38
COG2055,malate L-lactate dehydrogenase,C,144,28,2.41758E-38
COG0186,"One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal",J,284,27,1.7566E-38
COG4277,radical SAM domain protein,R,200,27,1.66743E-38
COG2364,Membrane,S,225,27,1.66712E-38
COG4198,conserved protein UCP033563,S,123,29,1.56949E-38
COG3392,Adenine-specific,L,177,29,9.51261E-39
COG1641,UPF0272 protein,S,208,28,9.48862E-39
COG2155,Conserved Protein,S,247,29,8.19244E-39
NOG05475,"site-specific recombinase, phage integrase family",L,103,27,6.24299E-39
COG0799,"Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)",S,233,27,5.90247E-39
NOG09204,Alcohol acetyltransferase,S,175,27,5.50741E-39
COG0378,"Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)",K,178,27,5.29073E-39
COG1929,Glycerate kinase,G,214,31,5.28693E-39
COG0197,Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity),J,308,27,5.14866E-39
NOG13887,[NoAnn],S,106,27,5.08877E-39
COG1875,Phoh family,T,122,27,4.68215E-39
COG1671,UPF0178 protein,S,170,27,4.61177E-39
COG1295,ribonuclease BN,S,222,27,4.32369E-39
NOG19349,Glycosyl Transferase,M,118,27,4.26542E-39
COG0759,Could be involved in insertion of integral membrane proteins into the membrane (By similarity),S,226,27,4.03531E-39
NOG88728,Helix-turn-helix,S,153,27,3.19719E-39
NOG02036,transposase mutator type,L,313,31,2.00438E-39
COG2268,Band 7 protein,S,178,28,1.87339E-39
NOG01307,binding domain) protein,C,182,28,1.80137E-39
NOG03754,transposase,L,263,28,1.22584E-39
COG2084,Dehydrogenase,I,136,29,1.13747E-39
COG0348,4Fe-4S Ferredoxin iron-sulfur binding domain protein,C,173,28,9.48606E-40
NOG05615,Divergent AAA domain protein,K,163,28,8.67329E-40
COG1121,(ABC) transporter,P,249,32,7.25258E-40
COG0560,phosphoserine phosphatase,E,183,28,4.5225E-40
COG3153,#NAME?,R,232,28,4.38411E-40
COG0659,sulfate transporter,P,145,28,4.16958E-40
COG1530,ribonuclease,J,193,28,4.1685E-40
COG1112,Helicase,L,250,28,4.00863E-40
COG1159,"An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)",R,409,28,3.98309E-40
COG5438,YibE F family protein,S,172,28,3.98038E-40
NOG05804,Metal Dependent Phosphohydrolase,R,147,28,3.22948E-40
NOG64457,RNA Polymerase,K,229,28,2.87388E-40
COG5015,pyridoxamine 5'-phosphate,S,230,28,2.34593E-40
COG0183,acetyl-coa acetyltransferase,I,255,28,1.68696E-40
COG2326,Polyphosphate kinase 2,S,136,28,1.52716E-40
COG3341,ribonuclease,S,124,28,1.51686E-40
COG1105,1-phosphofructokinase,G,253,30,1.50389E-40
NOG08555,[NoAnn],S,250,28,1.49672E-40
NOG42416,YolD-like protein,S,260,28,1.3774E-40
COG2316,Metal Dependent Phosphohydrolase,R,245,29,1.31409E-40
COG1496,Multi-copper polyphenol oxidoreductase laccase,S,293,28,1.30922E-40
COG4716,Myosin-Cross-Reactive Antigen,S,229,28,1.29771E-40
NOG21982,[NoAnn],S,223,29,1.2326E-40
COG3646,Phage regulatory protein rha,S,210,28,1.15478E-40
COG1206,Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity),J,223,28,1.14252E-40
COG3708,Transcriptional regulator,K,208,28,1.11357E-40
COG0841,acriflavin resistance protein,P,198,28,1.01646E-40
COG0299,phosphoribosylglycinamide formyltransferase,F,191,28,1.00655E-40
NOG36387,Transcriptional regulator,S,181,29,9.94881E-41
COG2194,Phosphoethanolamine transferase,R,147,28,9.89224E-41
COG3561,anti-repressor protein,K,219,29,6.69223E-41
COG1410,methionine synthase,E,220,33,6.29342E-41
NOG78963,small multi-drug export,S,166,29,4.22526E-41
COG0196,riboflavin biosynthesis protein ribF,H,272,30,4.14156E-41
NOG40175,Transposase,L,134,30,3.73648E-41
NOG02411,solute-binding protein,S,135,32,2.67796E-41
COG0505,carbamoyl-phosphate synthetase glutamine chain,F,258,30,2.65234E-41
COG1621,Hydrolase,G,246,30,2.0473E-41
COG1101,(ABC) transporter,R,296,29,1.92084E-41
NOG02394,Diaminopimelate dehydrogenase,E,153,30,1.81937E-41
NOG216349,HTH_XRE,K,143,29,1.70195E-41
COG3210,filamentous hemagglutinin family outer membrane protein,U,153,29,1.66226E-41
COG4983,[NoAnn],S,203,29,1.46742E-41
COG4284,pyrophosphorylase,G,193,29,1.1864E-41
COG2866,carboxy-peptidase,E,236,29,1.07162E-41
COG2896,"Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)",H,150,31,1.06231E-41
NOG84879,"Toxin-antitoxin system, antitoxin component, HicB family",S,159,32,1.0356E-41
COG3874,sporulation protein ytfj,S,201,30,8.79236E-42
NOG41944,[NoAnn],S,159,29,8.22917E-42
NOG79849,membrane protein implicated in regulation of membrane protease activity,S,173,29,7.56521E-42
NOG65714,[NoAnn],S,137,29,6.39408E-42
COG0070,glutamate synthase,E,238,31,6.0277E-42
COG2738,zinc metallopeptidase,R,236,33,5.9121E-42
COG1649,YngK protein,S,169,30,4.93016E-42
COG2876,phospho2-dehydro-3-deoxyheptonate aldolase,E,307,30,3.57372E-42
COG4769,heptaprenyl diphosphate synthase component I,S,201,33,3.15688E-42
COG4720,UPF0397 protein,S,121,30,2.97223E-42
NOG21725,sporulation protein YunB,S,164,30,2.75033E-42
COG3533,secreted protein,S,210,30,2.48174E-42
NOG39376,DNA-binding helix-turn-helix protein,K,220,30,1.92799E-42
COG5585,"head morphogenesis protein, SPP1 gp7 family",T,274,34,1.72458E-42
NOG02732,Transposase,L,120,30,1.58227E-42
COG0319,Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity),R,320,30,1.4859E-42
COG0440,Acetolactate synthase small subunit,E,230,30,1.15104E-42
COG0411,(ABC) transporter,E,211,30,9.10554E-43
COG3855,"D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3",G,183,31,9.06423E-43
COG0383,alpha-mannosidase,G,215,30,8.7554E-43
NOG39361,VTC domain protein,S,172,30,8.2977E-43
COG0040,Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity),E,185,31,7.72697E-43
COG0439,acetyl-CoA carboxylase biotin carboxylase,I,265,31,7.62335E-43
NOG00295,Amp-dependent synthetase and ligase,Q,210,32,7.2679E-43
COG1058,competence damage-inducible protein,H,233,30,5.93944E-43
COG0245,"Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)",I,289,33,5.88258E-43
NOG222319,[NoAnn],S,184,30,4.78716E-43
NOG89391,[NoAnn],S,180,33,4.33837E-43
NOG39335,[NoAnn],S,187,33,4.09752E-43
NOG07420,dexx-box atpase,R,172,30,4.06765E-43
COG3693,hydrolase family 10,G,214,30,3.70321E-43
NOG30591,Phage-Associated Protein,S,199,30,3.3537E-43
COG2274,(ABC) transporter,V,196,30,3.31762E-43
NOG03344,abc transporter permease protein,V,177,30,2.9985E-43
COG1026,peptidase,O,202,32,2.545E-43
COG2819,esterase,R,335,33,2.41442E-43
COG0470,DNA polymerase III subunit delta',L,182,30,2.3432E-43
NOG48985,Bacterial mobilization protein (MobC),S,141,31,2.01017E-43
COG0304,Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity),I,278,35,1.92977E-43
COG0128,5-enolpyruvylshikimate-3-phosphate synthase,E,296,31,1.11817E-43
COG1654,Biotin- acetyl-CoA-carboxylase ligase,H,229,32,1.11806E-43
COG2872,synthetase,R,202,31,1.05969E-43
COG1904,Uronic isomerase,G,204,31,1.02291E-43
COG3872,Metal-dependent enzyme,S,358,34,8.09952E-44
COG4636,Pfam:DUF820,S,155,31,6.99795E-44
COG2820,PhosPhorylase,F,221,31,6.74404E-44
COG3688,Tetracycline resistance protein,S,196,32,6.56122E-44
COG2966,Membrane,S,257,32,5.81625E-44
COG4725,MT-A70 family,K,163,31,5.62954E-44
NOG101383,Transcriptional regulator,K,207,31,5.01565E-44
COG1060,"Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)",H,212,31,3.89002E-44
COG0152,SAICAR synthetase,F,300,31,3.43792E-44
COG1001,adenine deaminase,F,211,31,3.08473E-44
NOG06044,"Toxin-antitoxin system, toxin component",S,76,35,2.95778E-44
COG0579,malate dehydrogenase (quinone),C,276,31,2.61442E-44
NOG00621,LysR family transcriptional regulator,K,137,35,2.48114E-44
COG1199,helicase,L,303,34,2.47031E-44
COG0167,Catalyzes the conversion of dihydroorotate to orotate,F,224,33,2.3825E-44
COG2070,2-Nitropropane dioxygenase,R,266,31,2.13487E-44
COG5496,thioesterase,R,198,31,2.0011E-44
NOG213119,AIG2 family,S,198,31,1.99961E-44
COG2025,Electron transfer flavoprotein,C,252,31,1.78949E-44
NOG19419,stage ii sporulation protein p,S,233,32,1.64112E-44
COG1312,Catalyzes the dehydration of D-mannonate (By similarity),G,179,31,1.42003E-44
COG0200,Binds to the 23S rRNA (By similarity),J,353,31,1.2797E-44
COG3711,transcriptional antiterminator,K,292,31,1.27013E-44
COG2011,ABC transporter (permease),P,218,31,1.26976E-44
COG1024,Enoyl-CoA hydratase,I,250,32,1.20489E-44
NOG92572,cell wall anchor domain protein,M,215,38,1.06586E-44
NOG00848,IMP cyclohydrolase-like protein,S,162,33,8.90196E-45
NOG00480,K05989 alpha-L-rhamnosidase EC 3.2.1.40,S,274,32,5.45424E-45
COG3760,prolyl-tRNA synthetase,S,327,32,4.74413E-45
COG4231,indolepyruvate ferredoxin oxidoreductase,C,179,34,4.16632E-45
COG4108,"Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)",J,283,33,3.5554E-45
COG1541,Phenylacetate-CoA ligase,Q,212,34,2.83222E-45
NOG03333,phage protein,S,252,32,1.99258E-45
NOG29974,Domain of unknown function (DUF1836),S,235,32,1.94255E-45
NOG13935,KWG leptospira repeat protein,S,209,37,1.83553E-45
COG0055,Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity),C,259,33,1.70291E-45
NOG11639,Minor capsid protein,S,293,38,1.33561E-45
NOG80738,prevent-host-death family,S,189,32,1.21054E-45
COG4708,Membrane,S,296,32,1.09014E-45
COG0237,Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity),H,277,32,1.08301E-45
COG3641,Membrane,S,243,32,7.94058E-46
COG0477,major facilitator Superfamily,G,314,52,6.99963E-46
COG1873,"sporulation protein, YlmC YmxH",S,256,32,6.97532E-46
NOG03110,Exonuclease,L,206,32,6.62804E-46
COG0098,Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity),J,333,32,6.30404E-46
COG1207,"Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)",M,282,33,5.76053E-46
COG0371,Dehydrogenase,C,275,33,5.28308E-46
COG2086,Electron transfer flavoprotein,C,253,32,5.28164E-46
NOG03944,DNA-damage-inducible protein d,S,174,32,4.42198E-46
COG0836,mannose-1-phosphate guanylyltransferase,M,200,33,3.81843E-46
COG3534,Alpha-N-arabinofuranosidase (EC 3.2.1.55),G,197,34,3.00513E-46
NOG00461,)-reductase,R,267,38,2.2978E-46
COG2205,Histidine kinase,T,323,34,1.37739E-46
COG4799,carboxylase,I,244,34,1.05254E-46
NOG05881,[NoAnn],S,298,33,9.73337E-47
COG2932,Repressor,K,160,34,9.15962E-47
COG0530,calcium exchanger,P,259,33,8.92042E-47
COG3507,hydrolase family 43,G,266,33,8.35733E-47
NOG30576,[NoAnn],S,250,33,8.12626E-47
COG0634,hypoxanthine phosphoribosyltransferase,F,281,34,7.97763E-47
COG3879,membrane associated protein,S,113,33,7.74526E-47
COG1811,Membrane,S,191,33,6.60342E-47
COG0117,"Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)",H,140,35,5.15995E-47
COG4845,chloramphenicol,V,185,33,4.94063E-47
NOG79962,feoA domain protein,P,318,33,4.51811E-47
NOG19832,phage terminase large subunit,R,212,33,3.90987E-47
COG1172,(ABC) transporter,G,299,36,3.39069E-47
COG1414,iclr family transcriptional regulator,K,335,33,3.32603E-47
COG1922,"Glycosyl transferase, wecb taga cpsf family",M,234,36,3.1329E-47
COG1034,subunit G,C,254,35,2.91679E-47
COG0284,Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity),F,256,38,2.51772E-47
COG0077,Prephenate dehydratase,E,282,34,2.49785E-47
COG0277,FAD linked oxidase domain protein,C,212,33,2.24921E-47
NOG01123,[NoAnn],S,276,33,1.71195E-47
COG1966,carbon starvation protein,T,317,34,1.65454E-47
NOG109868,[NoAnn],S,139,33,1.626E-47
COG0722,Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity),E,200,37,1.50487E-47
COG2355,Dipeptidase,E,280,35,1.41384E-47
COG0061,Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity),G,240,34,1.08599E-47
COG1713,Metal Dependent Phosphohydrolase,H,286,34,9.05053E-48
COG1702,Phoh family,T,319,34,8.17156E-48
COG4492,UPF0735 ACT domain-containing protein,E,244,40,7.28938E-48
COG1820,GlcNAc 6-P deacetylase,G,274,34,6.88165E-48
COG0786,Sodium Glutamate Symporter,E,159,34,6.34322E-48
COG1704,LemA family,S,249,35,6.01139E-48
COG0056,Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity),C,353,36,5.96101E-48
COG1117,Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity),P,262,34,5.21942E-48
COG1053,Succinate DeHydrogenase,C,267,34,4.90755E-48
NOG79064,[NoAnn],S,218,35,4.10226E-48
NOG69333,[NoAnn],S,332,34,3.90782E-48
NOG10277,Polysaccharide biosynthesis protein,S,190,35,3.80401E-48
COG0461,"Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)",F,231,38,3.18399E-48
COG1227,Manganese-dependent inorganic pyrophosphatase,C,295,37,3.06283E-48
COG4122,o-methyltransferase,R,226,35,2.87382E-48
COG0548,nag kinase,E,206,35,2.66114E-48
COG1040,Competence protein,R,287,35,2.13491E-48
COG1399,nucleic acidbinding protein,S,297,36,2.09082E-48
COG0212,5-formyltetrahydrofolate cyclo-ligase,H,259,36,2.07444E-48
COG0647,Hydrolase,G,254,34,1.76329E-48
COG0256,"This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)",J,406,34,1.65391E-48
COG0855,Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity),P,240,34,1.5185E-48
COG4658,Electron transport complex,C,273,37,1.49256E-48
COG3467,Resistance protein,S,301,35,1.29167E-48
COG0813,purine nucleoside phosphorylase DeoD-type,F,323,34,1.26556E-48
COG3705,Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity),E,240,36,1.12929E-48
NOG07749,minor capsid protein,S,221,35,9.56454E-49
NOG61121,repeat protein,S,368,51,8.96364E-49
COG1055,arsenical pump membrane protein,P,226,35,7.66617E-49
COG0063,"Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)",G,292,35,7.14778E-49
NOG28066,S-layer homology domain,S,212,34,6.78727E-49
COG0581,phosphate abc transporter,P,255,35,6.17926E-49
COG0792,UPF0102 protein,L,273,37,5.67059E-49
COG1489,Sugar fermentation stimulation protein homolog,R,168,35,4.71365E-49
COG0069,glutamate synthase,E,280,36,4.67619E-49
COG0531,amino acid,E,333,35,2.91171E-49
COG0165,argininosuccinate lyase,E,289,39,2.33961E-49
COG1188,heat shock protein,J,372,36,1.88828E-49
COG1529,"Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding",C,326,37,1.55484E-49
COG2607,ATPase (AAA,R,187,35,1.40983E-49
NOG70028,DNA-binding helix-turn-helix protein,K,176,35,9.01559E-50
COG4869,"Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity)",Q,273,35,8.90001E-50
COG1158,"Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)",K,217,35,8.23333E-50
COG2197,"Two component transcriptional regulator, LuxR family",T,244,36,8.08682E-50
NOG00666,Peptidoglycan-binding domain 1 protein,S,220,35,7.20643E-50
COG3944,biosynthesis protein,M,271,37,6.88696E-50
COG1837,UPF0109 protein,S,314,38,3.90815E-50
COG0025,Sodium hydrogen exchanger,P,148,35,3.62956E-50
COG2327,Polysaccharide pyruvyl transferase,M,201,36,2.98921E-50
NOG01467,"Efflux ABC transporter, permease protein",V,219,41,2.84703E-50
COG1559,aminodeoxychorismate lyase,R,307,36,2.7435E-50
NOG80394,"small acid-soluble spore protein, alpha beta type",S,329,48,2.05072E-50
COG2246,Gtra family,S,197,36,1.64188E-50
COG2768,4Fe-4S Ferredoxin iron-sulfur binding domain protein,C,381,42,1.00987E-50
COG2159,amidohydrolase 2,R,258,36,8.42722E-51
COG0080,This protein binds directly to 23S ribosomal RNA (By similarity),J,413,39,7.84543E-51
COG0540,aspartate transcarbamylase,F,275,36,7.35557E-51
NOG80594,sporulation protein yabp,S,290,36,6.81823E-51
COG1985,"Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)",H,181,38,5.08821E-51
COG0067,glutamate synthase,E,297,38,4.46434E-51
COG0014,Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity),E,276,36,4.42639E-51
COG3723,recT protein,L,180,36,3.97348E-51
NOG81396,[NoAnn],S,246,36,3.96736E-51
NOG79005,Zn-finger containing protein,S,226,36,3.48364E-51
COG0246,Mannitol dehydrogenase,G,242,36,3.34218E-51
COG1481,May be required for sporulation (By similarity),K,341,38,3.23046E-51
COG0240,glycerol-3-phosphate dehydrogenase,C,342,38,3.00177E-51
COG0154,Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity),J,343,36,2.87152E-51
COG0557,3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity),K,364,36,2.6396E-51
COG0283,Cytidine monophosphate kinase,F,334,38,2.45868E-51
NOG02813,[NoAnn],S,263,36,1.71004E-51
COG1476,Transcriptional regulator,K,447,39,1.35436E-51
COG0062,"Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity)",G,262,37,1.03198E-51
COG1854,"Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)",T,221,37,9.93806E-52
NOG58069,"Transposase, YhgA-like",S,189,37,8.97617E-52
COG4992,Acetylornithine aminotransferase,E,266,37,8.55748E-52
COG4866,conserved protein,S,243,37,7.11059E-52
COG1534,Rna-binding protein,J,210,38,5.88144E-52
COG5545,Virulence-associated protein e,S,316,38,5.55581E-52
COG0693,PfpI family,R,279,39,4.51136E-52
COG0497,May be involved in recombinational repair of damaged DNA (By similarity),L,315,39,4.02299E-52
COG0287,prephenate dehydrogenase,E,270,38,3.50913E-52
COG0142,synthase,H,259,38,3.40895E-52
COG0005,"The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)",F,284,37,3.23858E-52
COG0615,cytidylyltransferase,I,178,39,2.4898E-52
COG0363,Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity),G,306,40,2.43906E-52
COG0538,isocitrate dehydrogenase (NADp),C,181,37,2.1476E-52
COG1210,utp--glucose-1-phosphate uridylyltransferase,M,191,38,2.10717E-52
COG0213,"The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)",F,261,37,2.07281E-52
COG1203,"CRISPR-associated helicase, cas3",L,310,37,1.97942E-52
COG0221,Pyrophosphate phospho-hydrolase,C,300,37,1.76225E-52
COG0090,"One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity",J,512,37,1.64889E-52
COG2407,Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity),G,337,39,1.28916E-52
NOG80567,[NoAnn],S,226,38,1.244E-52
COG2033,Superoxide reductase,C,271,38,1.0785E-52
NOG50254,4Fe-4S ferredoxin iron-sulfur binding domain protein,C,262,37,8.7758E-53
NOG51448,Recombinase,S,288,39,7.72503E-53
COG1768,ser Thr protein phosphatase family protein,R,291,38,5.82147E-53
NOG34850,Dipicolinate synthase subunit A,R,216,44,5.1805E-53
NOG48337,Polysaccharide deacetylase,S,242,38,3.44898E-53
COG1177,Binding-protein-dependent transport systems inner membrane component,P,247,38,1.97192E-53
COG1573,uracil-dna glycosylase,L,253,38,1.97105E-53
NOG09006,[NoAnn],S,235,38,1.72215E-53
COG0332,Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity),I,251,38,1.48729E-53
COG1051,NUDiX hydrolase,F,210,38,1.09841E-53
COG1057,Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity),H,302,38,8.55316E-54
COG3669,alpha-l-fucosidase,G,262,38,8.5244E-54
COG4824,toxin secretion phage lysis holin,S,285,38,7.88276E-54
COG2035,Membrane,S,279,38,7.34071E-54
COG1680,Beta-lactamase,V,307,40,5.12287E-54
COG1035,Coenzyme F420 hydrogenase,C,225,38,4.78727E-54
COG3663,U mismatch-specific DNA glycosylase,L,242,39,4.66214E-54
NOG62802,conserved domain protein,S,225,38,4.31255E-54
COG1250,Dehydrogenase,I,252,38,4.09804E-54
COG0594,RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity),J,342,38,3.95393E-54
COG2358,"TRAP transporter, solute receptor (TAXI family",P,202,38,3.93324E-54
COG1434,conserved protein,S,279,40,3.09731E-54
COG1363,Peptidase m42 family protein,E,369,45,2.36984E-54
COG1381,Involved in DNA repair and RecF pathway recombination (By similarity),L,442,41,1.92031E-54
COG1482,mannose-6-phosphate isomerase,G,342,39,1.7994E-54
COG0325,alanine racemase domain protein,R,257,41,1.53952E-54
COG0646,methionine synthase,E,273,43,1.47379E-54
COG0335,This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity),J,481,40,1.38315E-54
COG1234,"Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)",R,287,39,1.22497E-54
NOG36531,Bacterial group 2 Ig-like protein,S,280,40,7.88394E-55
COG4193,endo-beta-N-acetylglucosaminidase,G,180,39,7.83236E-55
NOG07842,amidoligase enzyme,S,299,41,7.26224E-55
COG2510,Membrane,S,243,40,5.7734E-55
NOG04055,Glycosyl transferase group 1,M,217,39,5.62569E-55
COG3884,acyl-ACP thioesterase,I,258,39,5.16427E-55
COG0097,"This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)",J,464,40,4.75243E-55
COG0324,"Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)",J,334,39,4.21009E-55
COG1838,fumarate,C,225,39,3.99472E-55
COG1773,rubredoxin,C,238,39,3.19148E-55
COG3513,"Crispr-associated protein, Csn1 family",L,287,40,2.67105E-55
COG1893,Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity),H,297,39,2.01338E-55
COG0164,Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity),L,379,40,1.69241E-55
COG0351,phosphomethylpyrimidine kinase,H,214,41,1.56595E-55
COG0514,atp-dependent dna helicase,L,314,43,1.51025E-55
COG0518,Catalyzes the synthesis of GMP from XMP (By similarity),F,456,45,1.18128E-55
COG2262,GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity),R,308,40,6.43826E-56
COG2208,protein serine threonine phosphatase,T,369,44,5.12287E-56
COG1932,Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity),E,399,41,5.10752E-56
COG4186,Phosphoesterase,R,292,43,3.80921E-56
COG1080,General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity),G,307,40,2.78542E-56
NOG11267,Replication initiator protein A,L,348,40,2.46758E-56
COG4948,mandelate racemase muconate lactonizing,M,240,40,2.32837E-56
COG1385,Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity),S,340,40,1.96056E-56
COG0295,cytidine deaminase,F,376,41,1.75403E-56
COG3854,stage iii sporulation protein aa,R,377,40,1.65739E-56
COG1268,bioY protein,R,376,42,1.51971E-56
COG0669,"Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)",H,292,40,1.38906E-56
COG0116,Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity),L,318,40,1.30417E-56
COG0059,Alpha-keto-beta-hydroxylacyl reductoisomerase,E,218,40,1.01892E-56
NOG79923,PTS HPr component phosphorylation site,S,222,40,9.44187E-57
COG3619,membrAne,S,240,40,9.32895E-57
COG2804,type ii secretion system protein e,U,237,41,7.2997E-57
COG0301,"Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)",H,332,42,7.08261E-57
COG1874,beta-galactosidase,G,274,40,6.55851E-57
COG3858,"hydrolase, family 18",G,301,41,6.06134E-57
COG0072,phenylalanyl-tRNA synthetase (beta subunit),J,466,42,5.94869E-57
NOG62139,"transcriptional regulator, CarD family",K,218,41,5.55303E-57
COG5632,n-acetylmuramoyl-l-alanine amidase,M,344,42,5.48523E-57
COG1015,Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity),G,258,42,4.9826E-57
COG0050,This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity),J,490,44,2.65869E-57
COG4667,"Phospholipase, patatin family",R,303,41,2.1943E-57
COG2890,Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity),J,402,41,1.80835E-57
COG1939,Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc),S,381,44,1.22434E-57
COG2309,aminopeptidase,E,302,41,1.18294E-57
COG3886,type iii restriction protein res subunit,L,232,43,9.99329E-58
COG1502,Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity),I,436,58,9.46197E-58
COG4096,type I restriction-modification system R subunit,V,348,41,7.42172E-58
COG0718,"Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)",S,331,41,7.26378E-58
COG0092,"Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)",J,397,41,6.7746E-58
COG1792,Involved in formation and maintenance of cell shape (By similarity),M,294,42,6.64249E-58
COG1285,mgtC SapB transporter,S,289,45,6.29484E-58
COG4886,leucine Rich Repeat,S,258,43,5.69496E-58
COG1989,Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity),N,191,42,4.08875E-58
COG0041,Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity),F,321,41,3.88229E-58
COG1120,(ABC) transporter,P,326,43,3.20583E-58
COG0252,L-asparaginase,E,269,45,3.15525E-58
NOG38252,domain) protein,S,228,43,2.65445E-58
COG1522,transcriptional regulator AsnC family,K,368,45,2.33241E-58
COG1847,Single-stranded nucleic acid binding R3H domain-containing protein,R,385,42,1.80476E-58
COG0345,pyrroline-5-carboxylate reductase,E,314,42,1.72487E-58
COG2340,Scp-like extracellular,S,298,43,1.67287E-58
COG1366,stage II sporulation protein,T,398,42,1.51142E-58
COG0125,Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity),F,316,44,1.04668E-58
NOG55962,S-layer homology domain,S,327,42,1.03651E-58
COG0685,Methylenetetrahydrofolate reductase,E,293,42,1.02076E-58
COG0576,"Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ",O,411,42,8.36695E-59
COG0687,extracellular solute-binding protein family 1,E,281,42,8.19021E-59
COG0185,Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity),J,323,42,8.0416E-59
NOG04681,(LipO)protein,S,203,42,6.1332E-59
COG1775,2-hydroxyglutaryl-CoA dehydratase,E,332,42,5.12155E-59
COG1490,Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity),J,297,42,5.08695E-59
COG4962,type ii secretion system protein E,U,385,43,4.57678E-59
COG0263,Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity),E,315,42,3.39774E-59
COG0458,carbamoyl-phosphate synthetase ammonia chain,F,319,42,3.17765E-59
COG1074,"The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation",L,355,43,3.10818E-59
COG3049,Choloylglycine hydrolase,M,281,42,2.45617E-59
COG0737,5-Nucleotidase,F,326,43,2.45008E-59
COG4868,UPF0371 protein,S,333,44,2.41147E-59
NOG05968,[NoAnn],S,233,42,2.30144E-59
NOG01056,Transposase,L,236,44,2.16871E-59
NOG00672,transcriptional regulator laci family,K,289,42,2.12441E-59
COG0203,50S ribosomal protein l17,J,419,42,2.00334E-59
COG3728,terminase (Small subunit),L,243,47,1.97224E-59
NOG82246,DNA-binding helix-turn-helix protein,K,216,43,1.7446E-59
COG1079,ABC transporter (permease),R,356,42,1.72643E-59
COG0575,phosphatidate Cytidylyltransferase,I,369,45,7.14326E-60
COG2740,Nucleic-acid-binding protein implicated in transcription termination,K,362,43,6.02512E-60
NOG06203,DNA polymerase,L,404,44,4.47797E-60
COG1840,"extracellular solute-binding protein, family 1",P,303,45,4.35486E-60
NOG17130,coenzyme F420 hydrogenase dehydrogenase beta subunit domain protein,C,277,43,4.31574E-60
COG1091,Dtdp-4-dehydrorhamnose reductase,M,319,51,3.48316E-60
NOG09578,Plasmid recombination enzyme,S,322,43,2.77774E-60
NOG06896,Transposase (IS4 family) protein,L,234,44,2.72934E-60
COG4695,Phage Portal Protein,R,303,43,2.55561E-60
COG5016,Oxaloacetate decarboxylase,C,285,43,2.42279E-60
NOG88152,HNH endonuclease,V,228,43,2.34877E-60
COG3599,"Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)",D,245,44,2.33852E-60
NOG01649,[NoAnn],S,296,44,2.21045E-60
NOG00681,domain protein,S,220,43,1.95483E-60
NOG14860,"Transcriptional regulator, TetR family",K,203,43,1.32229E-60
COG0700,nucleoside recognition domain protein,S,335,45,1.1986E-60
COG1690,"Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs (By similarity)",S,196,44,1.14129E-60
COG2894,site-determining protein,D,348,44,1.01603E-60
COG1493,"Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)",T,350,43,9.86173E-61
NOG48681,TraX protein,S,268,49,9.6129E-61
COG1066,May play a role in the repair of endogenous alkylation damage (By similarity),O,400,43,9.28633E-61
COG0821,"Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)",I,295,44,9.13925E-61
COG0035,Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity),F,334,43,8.1235E-61
NOG00088,[NoAnn],S,314,45,6.82907E-61
COG0150,phosphoribosylaminoimidazole synthetase,F,260,43,6.48818E-61
NOG04858,sporulation protein yqfd,S,313,43,6.34295E-61
NOG12195,phage protein,R,224,43,6.2204E-61
COG1694,MazG family,R,324,43,4.55274E-61
COG0552,Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC),U,333,48,4.18644E-61
COG1364,"Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)",E,220,45,2.90292E-61
NOG100039,DNA binding,L,234,44,2.21252E-61
COG1397,ADP-ribosylation Crystallin J1,O,399,45,1.7424E-61
COG0597,This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity),M,345,45,1.54186E-61
COG1960,acyl-CoA dehydrogenase,I,321,44,1.20644E-61
COG4177,(ABC) transporter,E,268,46,1.14909E-61
COG0268,Binds directly to 16S ribosomal RNA (By similarity),J,274,46,1.09937E-61
COG0708,Exodeoxyribonuclease III,L,306,44,7.98278E-62
COG4468,UDP-glucose-hexose-1-phosphate uridylyltransferase,G,245,44,7.36693E-62
COG0381,UDP-N-acetylglucosamine 2-epimerase,M,372,44,6.72601E-62
COG2220,Hydrolase,R,391,44,6.01367E-62
NOG02184,Two component transcriptional regulator (Winged helix family,T,256,47,5.48432E-62
COG5001,Diguanylate cyclase phosphodiesterase,T,311,45,5.26201E-62
COG0201,"The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)",U,470,44,4.88793E-62
COG0289,Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity),E,324,46,4.82677E-62
COG0082,5-enolpyruvylshikimate-3-phosphate phospholyase,E,291,45,4.46858E-62
COG0858,Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity),J,352,44,3.87857E-62
COG0761,Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity),I,312,44,3.74369E-62
COG0091,"The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)",J,351,45,2.28726E-62
COG0274,Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity),F,355,45,1.60194E-62
COG0262,"Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)",H,312,45,1.48858E-62
NOG67733,Abortive infection protein AbiGI,S,298,45,1.27459E-62
COG0251,Endoribonuclease LPSP,J,355,46,1.15442E-62
COG0047,phosphoribosylformylglycinamidine synthase,F,257,45,9.80341E-63
COG1523,Glycogen debranching enzyme,G,221,45,9.0462E-63
COG4464,Capsular polysaccharide biosynthesis protein,G,333,45,7.61406E-63
COG1272,Channel protein (Hemolysin III family,R,300,46,6.60906E-63
NOG00312,[NoAnn],S,250,48,4.52911E-63
COG1576,Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity),S,325,45,4.12224E-63
COG0361,"however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)",J,307,45,3.89585E-63
COG0096,"One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)",J,510,45,3.84677E-63
COG1533,radical SAM domain protein,L,265,47,3.75313E-63
NOG34330,[NoAnn],S,444,45,3.68054E-63
COG3437,Response Regulator,T,312,56,3.00903E-63
COG0089,One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity),J,290,45,2.10119E-63
COG5377,phage-type endonuclease,L,371,45,1.8592E-63
NOG32713,Cpl-7 lysozyme C-terminal domain protein,M,224,45,1.72911E-63
COG1135,Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity),P,335,46,1.50697E-63
COG3848,Pyruvate kinase,G,200,45,1.22064E-63
COG0424,Maf-like protein,D,330,49,1.06652E-63
NOG51563,stage ii sporulation protein r,S,394,48,8.79129E-64
COG1464,(Lipo)protein,P,339,46,8.07362E-64
COG2348,Methicillin resistance protein,V,221,48,7.49527E-64
COG1883,decarboxylase beta subunit,C,402,49,5.12863E-64
COG0046,phosphoribosylformylglycinamidine synthase,F,259,46,4.41995E-64
COG0513,atp-dependent rna helicase,L,345,47,4.05406E-64
COG0356,it plays a direct role in the translocation of protons across the membrane (By similarity),C,329,49,3.98369E-64
COG0337,3-dehydroquinate synthase,E,294,47,3.7896E-64
COG1269,ATPase 116 kDa subunit,C,212,47,2.67062E-64
COG0016,"phenylalanyL-tRNA synthetase, alpha subunit",J,527,49,2.645E-64
NOG01781,Histidine kinase,T,294,47,2.32499E-64
NOG01009,[NoAnn],S,334,46,1.73798E-64
COG3830,UPF0237 protein,E,274,47,1.56907E-64
COG0502,Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity),H,320,55,1.07635E-64
COG1466,DNA polymerase III (delta' subunit),L,323,48,1.02109E-64
COG1739,"protein family UPF0029, Impact, N-terminal protein",S,410,49,9.89031E-65
COG0347,Nitrogen regulatory protein pii,E,314,46,8.57228E-65
COG4120,ABC transporter (permease),R,405,46,5.92553E-65
COG1624,TIGR00159 family,S,528,47,5.19941E-65
COG0519,Catalyzes the synthesis of GMP from XMP (By similarity),F,478,52,4.24671E-65
COG0024,Removes the N-terminal methionine from nascent proteins (By similarity),J,403,48,3.3159E-65
COG1264,pts system,G,371,48,3.12953E-65
NOG79200,[NoAnn],S,350,51,1.6038E-65
COG0692,Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity),L,286,47,1.55074E-65
COG1970,Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity),M,275,51,8.98843E-66
COG1351,Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity),F,347,48,6.56823E-66
COG0326,Molecular chaperone. Has ATPase activity (By similarity),O,460,48,6.44261E-66
NOG18658,DNA-binding helix-turn-helix protein,S,437,47,4.15284E-66
COG0352,Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity),H,280,47,3.89665E-66
COG0223,Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity),J,373,47,3.89243E-66
COG1897,Homoserine O-transsuccinylase,E,301,51,3.62658E-66
NOG26875,Polysaccharide deacetylase,S,297,47,3.27012E-66
COG0336,Specifically methylates guanosine-37 in various tRNAs (By similarity),J,469,53,3.26061E-66
NOG80504,VRR-NUC domain protein,S,221,47,3.24897E-66
COG0009,sua5 ycio yrdc ywlc family protein,J,409,47,2.89497E-66
COG0151,Phosphoribosylglycinamide synthetase,F,263,47,2.44792E-66
COG0015,adenylosuccinate lyase,F,383,48,2.28474E-66
NOG41036,Ser Thr phosphatase family protein,R,307,48,2.20605E-66
COG3935,DNA replication protein DnaD,L,395,49,1.86383E-66
COG1435,THymidine Kinase,F,271,47,1.79854E-66
NOG34670,"von Willebrand factor, type A",R,258,47,1.70493E-66
COG0341,Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity),U,264,48,1.2467E-66
NOG64437,Stage v sporulation protein ae,S,332,49,6.43738E-67
COG4656,Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity),C,425,51,5.39451E-67
NOG79057,[NoAnn],S,374,50,4.74909E-67
COG0573,phosphate abc transporter,P,372,48,4.33057E-67
NOG01264,[NoAnn],S,284,48,4.01311E-67
NOG08851,(ABC) transporter,R,271,48,3.66056E-67
COG1186,Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity),J,503,50,3.23324E-67
NOG33236,[NoAnn],S,166,49,3.06282E-67
COG0803,periplasmic solute binding protein,P,350,49,2.95213E-67
COG0600,Binding-protein-dependent transport systems inner membrane component,P,453,49,2.14267E-67
COG0609,permease protein,P,406,50,2.01977E-67
COG0236,Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity),I,363,48,1.7809E-67
COG0169,shikimate dehydrogenase,E,354,48,1.34762E-67
COG2755,lipolytic protein G-D-S-L family,E,416,51,1.31516E-67
COG1887,CDP-glycerol poly(glycerophosphate) glycerophosphotransferase,M,386,49,1.06406E-67
COG0845,Efflux transporter RND family MFP subunit,M,382,48,8.44062E-68
COG0215,Cysteinyl-tRNA synthetase,J,492,51,8.00886E-68
COG1176,"Binding-protein-dependent transport systems, inner membrane component",P,274,51,7.39763E-68
COG0816,Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity),L,458,49,3.20318E-68
COG0696,Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity),G,485,49,2.15023E-68
COG3459,Glycosyltransferase 36,G,342,50,2.0302E-68
COG1947,Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity),I,348,50,1.99097E-68
COG2384,sam-dependent methyltransferase,R,353,51,1.65952E-68
COG0598,magnesium and cobalt transport protein CorA,P,364,49,1.25377E-68
NOG104557,[NoAnn],S,316,50,1.03594E-68
COG1215,"Glycosyl transferase, family 2",M,358,50,9.59702E-69
COG1619,"Peptidase U61, LD-carboxypeptidase A",V,290,53,8.88212E-69
NOG58177,relaxase Mobilization nuclease,S,345,50,6.84992E-69
COG0486,"Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)",R,488,53,6.20674E-69
COG0793,protease,M,407,50,5.5903E-69
COG0004,ammonium Transporter,P,270,49,4.16469E-69
COG1804,l-carnitine dehydratase bile acid-inducible protein F,C,207,54,4.13984E-69
COG0300,Dehydrogenase reductase,R,372,50,3.83928E-69
COG0207,Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity),F,323,51,2.56856E-69
COG1196,Required for chromosome condensation and partitioning (By similarity),D,369,51,2.00186E-69
COG4123,Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity),R,383,51,9.14956E-70
COG0427,Acetyl-CoA hydrolase,C,298,50,8.31784E-70
COG0828,30S ribosomal protein S21,J,350,52,7.72368E-70
COG0184,Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity),J,425,52,7.2101E-70
COG1242,radical SAM protein,R,292,50,6.43046E-70
COG1236,cleavage and polyadenylation,J,301,51,5.90011E-70
COG1022,Amp-dependent synthetase and ligase,I,385,51,5.58795E-70
COG4485,Membrane,S,304,54,5.13092E-70
COG0290,"IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)",J,442,51,3.28515E-70
COG0292,Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity),J,510,52,3.06559E-70
COG0648,Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity),L,367,50,2.97059E-70
COG0127,"Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)",F,317,50,2.79656E-70
COG2264,Methylates ribosomal protein L11 (By similarity),J,337,51,2.74918E-70
COG0136,Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity),E,399,51,2.56766E-70
COG1982,decarboxylase,E,462,50,2.43908E-70
COG0523,cobalamin synthesis protein,R,548,54,2.12215E-70
COG1477,(LipO)protein,H,390,50,2.01686E-70
COG2177,Part of the ABC transporter FtsEX involved in,D,341,50,1.74174E-70
COG1518,"CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)",L,416,51,1.72685E-70
COG0039,Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity),C,387,52,1.70376E-70
COG1555,Competence protein,L,347,68,9.28162E-71
COG4472,UPF0297 protein,S,411,51,6.73328E-71
NOG61847,"Glycosyl transferase, family 2",M,343,51,4.99419E-71
COG0130,Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity),J,403,52,4.88944E-71
COG0138,bifunctional purine biosynthesis protein PURH,F,268,52,4.85308E-71
NOG09289,relaxase Mobilization nuclease domain protein,S,360,52,3.84228E-71
COG0313,Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity),R,353,51,3.79647E-71
COG2252,Xanthine uracil vitamin C permease,R,368,51,3.77055E-71
COG2610,Gluconate,E,262,51,3.33917E-71
COG4474,UPF0398 protein,S,229,51,3.28614E-71
COG4632,Exopolysaccharide biosynthesis protein,G,317,54,2.92825E-71
COG0065,"Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)",E,300,53,2.80551E-71
COG0344,"Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)",S,361,53,2.71012E-71
COG0253,"Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)",E,455,53,2.62756E-71
COG2848,UPF0210 protein,S,332,54,1.93728E-71
COG0254,50S ribosomal protein L3-1,J,376,51,1.60152E-71
NOG07441,nuclease,S,330,52,1.60088E-71
COG0445,"NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)",D,425,56,1.28541E-71
COG0078,ornithine carbamoyltransferase,E,403,52,1.23335E-71
COG0228,30s ribosomal protein S16,J,410,52,1.14055E-71
COG0775,"Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)",F,328,52,1.11391E-71
COG0683,ABC transporter substrate-binding protein,E,384,51,9.77684E-72
COG0048,"Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)",J,413,53,9.38775E-72
COG0572,uridine kinase,F,502,57,6.52815E-72
COG1442,Glycosyl transferase family 8,M,409,52,6.2505E-72
NOG00535,"Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity)",O,410,53,5.87503E-72
COG1211,Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity),I,490,55,5.57237E-72
COG1803,Methylglyoxal synthase,G,327,52,4.25463E-72
COG2200,Diguanylate cyclase phosphodiesterase,T,306,53,3.48103E-72
NOG101208,"Transcriptional regulator, MarR Family",K,410,53,2.21949E-72
COG0806,"An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)",J,477,54,1.95713E-72
COG0020,Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity),I,455,56,1.88976E-72
COG1994,peptidase (M50,R,421,54,1.74802E-72
COG0211,50S ribosomal protein l27,J,407,52,1.48499E-72
COG0460,homoserine dehydrogenase,E,355,59,1.28735E-72
NOG08746,Helix-turn-helix,S,260,52,1.04693E-72
COG2723,beta-glucosidase,G,451,54,8.93002E-73
COG2172,anti-sigma regulatory factor serine threonine protein kinase,T,527,54,8.01113E-73
COG0153,Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity),G,398,52,8.00858E-73
COG0820,Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs,J,352,52,6.39688E-73
COG1281,Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity),O,317,52,6.33175E-73
COG1020,non-ribosomal peptide synthetase,Q,289,53,5.48402E-73
COG0658,DNA internalization-related competence protein ComEC Rec2,R,410,54,5.01273E-73
COG0353,May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity),L,367,52,4.96378E-73
COG0297,"Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)",G,362,55,3.65737E-73
COG0607,Rhodanese domain protein,P,278,56,3.53314E-73
COG0800,Aldolase,G,359,55,2.85326E-73
COG0719,Fe-S assembly protein,O,527,66,2.57861E-73
COG0402,deaminase,F,581,53,8.77367E-74
COG1193,muts2 protein,L,423,59,6.44807E-74
COG0218,Necessary for normal cell division and for the maintenance of normal septation (By similarity),R,360,55,6.27354E-74
COG2315,"protein, conserved in bacteria",S,309,53,3.13311E-74
COG0532,One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity),J,425,54,3.00589E-74
COG4823,Abortive infection bacteriophage resistance protein,V,266,53,2.95393E-74
COG0846,NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form,K,599,56,2.68959E-74
COG0456,#NAME?,R,436,54,2.60372E-74
COG0174,glutamine synthetase,E,364,55,2.36063E-74
COG0340,Biotin- acetyl-CoA-carboxylase ligase,H,414,56,2.32257E-74
COG0285,Folylpolyglutamate synthase,H,396,53,1.81109E-74
COG1087,udp-glucose 4-epimerase,M,463,54,1.80853E-74
COG1197,transcriptioN-repair coupling factor,L,395,55,1.21279E-74
COG4481,"protein, conserved in bacteria",S,302,58,8.83981E-75
COG2190,pts system,G,409,58,8.26827E-75
COG3958,Transketolase,G,407,55,7.42015E-75
COG3409,Peptidoglycan-binding domain 1 protein,M,431,54,7.39304E-75
COG3857,"The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination",L,464,54,6.75686E-75
COG0559,(ABC) transporter,E,397,54,6.63161E-75
COG4100,aluminum resistance protein,P,387,57,6.07399E-75
COG0357,Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity),M,402,54,5.51852E-75
COG0233,Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity),J,426,58,4.46064E-75
COG0216,Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity),J,453,55,2.58888E-75
COG2344,Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity),K,367,57,2.47659E-75
COG0742,methyltransferase,L,410,54,1.90176E-75
COG3345,alpha-galactosidase,G,380,55,1.74431E-75
COG0584,glycerophosphoryl diester phosphodiesterase,C,442,56,1.14042E-75
COG0741,transglycosylase,M,384,54,7.86455E-76
NOG03660,transposase,L,283,55,7.18958E-76
COG1313,radical SAM domain protein,R,355,56,5.90378E-76
NOG08821,[NoAnn],S,430,58,5.34978E-76
COG2183,domain) protein,K,427,56,4.83556E-76
COG0281,malic enzyme,C,360,55,3.11289E-76
NOG07385,terminase (large subunit),R,372,55,2.53719E-76
COG0422,Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity),H,138,57,1.54263E-76
COG1561,YicC domain protein,S,358,55,1.28523E-76
COG1546,competence damage-inducible protein,R,361,55,1.20786E-76
COG0703,Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity),E,414,55,8.86609E-77
COG3887,domain protein,T,396,65,8.39336E-77
COG0802,"protein family UPF0079, ATPase",R,436,56,8.34503E-77
COG0219,Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity),J,418,55,7.63605E-77
COG1951,fumarate,C,272,57,3.32483E-77
COG0367,asparagine synthetase,E,436,55,3.31112E-77
COG0419,Involved in DNA double-strand break repair (DSBR). The Rad50 Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and or repositioning DNA ends into the Mre11 active site (By similarity),L,305,57,3.04022E-77
COG1866,Phosphoenolpyruvate Carboxylase,C,289,59,2.99803E-77
COG1386,Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity),K,386,55,2.837E-77
COG1544,sigma 54 modulation protein ribosomal protein S30ea,J,479,57,2.63578E-77
COG0342,Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity),U,331,56,2.38601E-77
COG0618,phosphoesterase RecJ domain protein,R,504,57,2.24691E-77
COG1511,domain protein,S,386,56,2.19913E-77
COG0013,Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity),J,439,59,2.14918E-77
COG0323,"This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)",L,463,56,1.23664E-77
COG1393,Arsenate Reductase,P,400,58,1.08057E-77
COG1401,ATPase associated with various cellular activities aaa_5,V,420,56,9.68352E-78
COG2856,Transcriptional regulator,E,287,57,9.58932E-78
COG0149,triosephosphate isomerase,G,479,56,5.67602E-78
COG1335,isochorismatase,Q,403,56,2.42542E-78
COG0250,"Participates in transcription elongation, termination and antitermination (By similarity)",K,591,70,1.95341E-78
COG1459,Type ii secretion system,U,249,59,1.64515E-78
COG3314,nucleoside recognition domain protein,S,375,57,1.35777E-78
NOG41045,[NoAnn],S,343,66,6.9842E-79
COG0562,UDP-galactopyranose mutase,M,351,57,4.57814E-79
COG0620,Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity),E,197,63,3.69375E-79
COG0049,"One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)",J,466,58,3.44641E-79
COG0115,brancheD-chain amino acid aminotransferase,E,434,60,3.44531E-79
COG1116,(ABC) transporter,P,510,61,2.41049E-79
COG0019,Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity),E,530,59,2.08378E-79
NOG09567,domain protein,S,466,62,2.07571E-79
COG3829,Transcriptional regulator,K,378,57,1.91923E-79
COG1162,May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity),R,381,57,1.47683E-79
COG2715,nucleoside recognition domain protein,S,386,57,1.34054E-79
COG2720,VanW family,V,439,59,1.16565E-79
COG4603,ABC transporter (permease),R,423,57,9.98975E-80
COG1168,Aminotransferase,E,387,57,8.45358E-80
NOG04916,(ABC) transporter,R,272,59,6.83883E-80
COG1388,domain protein,M,385,59,6.76646E-80
COG1640,4-alpha-glucanotransferase,G,421,58,6.31088E-80
COG2502,asparagine synthetase a,E,312,61,4.20614E-80
COG1048,aconitate hydratase,C,366,58,3.71413E-80
COG4728,Protein of unknown function (DUF1653),S,345,58,2.84675E-80
COG0100,"Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)",J,478,58,1.80821E-80
COG2739,Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity),S,433,61,1.30903E-80
NOG48404,RNA polymerase sigma factor,K,575,61,1.30622E-80
COG0632,"The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)",L,442,58,1.10044E-80
COG0781,Involved in the transcription termination process (By similarity),K,419,59,1.07839E-80
COG1228,amidohydrolase,Q,412,58,9.27842E-81
COG3666,transposase,L,494,59,8.18239E-81
COG0248,ppx gppa phosphatase,F,321,58,8.02814E-81
COG0051,Involved in the binding of tRNA to the ribosomes (By similarity),J,429,58,6.41103E-81
COG0525,"amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)",J,522,60,6.16961E-81
COG0758,DNA protecting protein DprA,L,415,59,4.56483E-81
NOG00981,(ABC) transporter,R,464,58,3.25037E-81
COG0086,DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity),K,420,59,2.38082E-81
COG0675,Transposase,L,301,61,1.61829E-81
COG0173,aspartyl-trna synthetase,J,595,59,1.58505E-81
COG0372,citrate synthase,C,418,61,1.48692E-81
COG0617,"Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate",J,538,62,1.41451E-81
COG3727,DNA mismatch endonuclease (vsr),L,315,59,1.19461E-81
COG2302,s4 domain protein,J,316,61,1.1441E-81
COG0350,Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity),L,465,61,9.03962E-82
COG1896,Metal Dependent Phosphohydrolase,R,442,60,8.70819E-82
COG3581,coA-substrate-specific enzyme activase,S,399,59,6.63788E-82
NOG00810,Cytidylate kinase,S,507,60,6.61744E-82
NOG31427,"transcriptional regulator, araC family",K,274,59,4.83699E-82
NOG03773,Plasmid segregation actin-type ATPase ParM,S,392,59,3.01541E-82
NOG38081,[NoAnn],S,275,61,2.41698E-82
COG0776,"This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)",L,617,61,2.19761E-82
COG2206,Metal Dependent Phosphohydrolase,T,415,60,2.11885E-82
COG2214,DNAj domain protein,O,340,60,9.41009E-83
COG0554,Key enzyme in the regulation of glycerol uptake and metabolism (By similarity),C,361,60,9.16402E-83
COG2255,"The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)",L,449,60,7.42245E-83
COG1902,"NADH flavin oxidoreductase, NADH oxidase",C,560,61,5.89406E-83
COG2267,alpha beta hydrolase fold,I,438,71,3.89014E-83
COG0177,endonuclease III,L,482,65,3.68694E-83
NOG82793,Hydrid cluster protein-associated redox disulfide domain protein,S,301,63,3.66528E-83
COG4219,Peptidase m56,K,449,66,3.51296E-83
COG0817,Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity),L,324,62,2.9896E-83
COG0537,histidine triad (hIT) protein,F,431,60,2.49841E-83
COG2884,Cell division ATP-binding protein ftsE,D,460,60,2.09147E-83
COG1106,Abortive infection protein,S,436,61,1.96022E-83
COG1086,polysaccharide biosynthesis protein,M,428,60,1.70675E-83
COG1420,Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity),K,587,63,1.53314E-83
COG0464,Aaa atpase,O,396,61,1.0213E-83
COG1461,dak2 domain fusion protein ylov,R,379,65,9.85622E-84
COG0261,This protein binds to 23S rRNA in the presence of protein L20 (By similarity),J,507,62,9.62239E-84
COG1879,Periplasmic binding protein LacI transcriptional regulator,G,568,66,4.87631E-84
NOG19788,Polysaccharide pyruvyl transferase,S,361,61,2.73208E-84
COG1451,metaL-dependent hydrolase,R,396,61,2.49782E-84
COG0190,"Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)",H,444,63,2.45108E-84
COG2001,Cell division protein mraZ,S,533,65,2.39418E-84
COG0416,"Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)",I,375,61,9.07593E-85
NOG10832,"site-specific recombinase, phage integrase family",L,393,64,8.41208E-85
COG0129,Dihydroxy-acid dehydratase,E,364,64,8.27567E-85
COG0235,Class II aldolase adducin,G,510,62,7.0569E-85
COG0522,"One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)",J,408,62,5.18396E-85
NOG00136,stage V sporulation protein ad,S,451,62,4.79172E-85
COG0563,Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity),F,465,64,4.39235E-85
COG2730,Glycoside hydrolase Family 5,G,430,73,3.70587E-85
COG1278,Cold shock protein,K,319,64,3.29212E-85
COG1161,Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity),R,564,62,1.49938E-85
COG0536,"An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control",R,482,64,1.40454E-85
COG2071,Glutamine amidotransferase,R,342,66,8.89747E-86
COG0459,Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity),O,500,63,7.23634E-86
COG1774,psp1 domain protein,S,401,63,2.8873E-86
COG3959,Transketolase,G,518,63,2.73307E-86
COG0343,"Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)",J,498,62,1.90687E-86
COG0359,Binds to the 23S rRNA (By similarity),J,435,65,1.69319E-86
COG0282,Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity),C,513,62,1.32636E-86
COG2843,Capsule synthesis protein,M,446,62,1.08827E-86
COG1846,Transcriptional regulator,K,437,63,7.20683E-87
COG1760,L-serine dehydratase,E,502,67,6.47075E-87
NOG39676,"site-specific recombinase, phage integrase family",L,393,67,6.29261E-87
COG1033,RND superfamily,R,402,64,6.21753E-87
NOG08156,Toprim domain protein,S,486,63,5.76389E-87
COG1925,phosphocarrier protein (HPr),G,517,63,5.4125E-87
COG1354,Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity),S,404,63,5.28019E-87
COG0631,Phosphatase,T,506,66,4.59916E-87
COG2240,Pyridoxal kinase,H,315,64,4.30385E-87
NOG35516,Transcriptional regulator,K,396,63,3.28553E-87
COG0735,"Ferric uptake regulator, Fur family",K,496,63,2.86611E-87
COG0706,"Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins",U,532,65,2.13642E-87
COG1198,Primosomal protein n',L,499,63,1.66938E-87
COG1052,Dehydrogenase,C,441,63,1.59238E-87
COG2131,deaminase,F,501,65,1.57031E-87
COG0101,"Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)",J,547,66,1.4322E-87
COG0264,Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity),J,479,67,7.79964E-88
COG2186,GntR family transcriptional regulator,K,416,64,7.42999E-88
COG0112,"Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)",E,491,64,7.32963E-88
COG0452,Phosphopantothenoylcysteine decarboxylase,H,413,71,6.81669E-88
COG0036,ribulose-phosphate 3-epimerase,G,457,63,6.31185E-88
COG2017,"converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)",G,484,64,5.21252E-88
COG0527,Aspartokinase,E,465,67,2.82861E-88
COG0396,feS assembly ATPase SufC,O,456,78,2.57853E-88
COG0473,Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity),E,334,66,1.45421E-88
COG0220,Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity),R,449,65,9.03473E-89
COG0296,"Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)",G,494,64,8.37241E-89
COG0504,Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity),F,448,66,5.44748E-89
COG1593,trap dicarboxylate transporter dctm subunit,G,465,64,4.13816E-89
COG2323,Membrane,S,528,65,4.08648E-89
COG1479,conserved protein,S,416,66,3.68539E-89
COG0606,Mg chelatase subunit ChlI,O,420,66,3.51499E-89
COG1783,phage terminase (large subunit),R,416,68,3.45367E-89
COG5283,Phage Tail Tape Measure Protein,S,483,66,2.81206E-89
NOG19511,DNA repair protein RadA domain,S,659,64,2.68885E-89
COG1214,Peptidase M22 Glycoprotease,O,420,67,2.43327E-89
COG3546,Catalase,P,536,68,2.39869E-89
COG1154,Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity),H,435,67,2.23421E-89
NOG87500,Helix-turn-helix,K,456,64,1.92221E-89
COG0541,Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY,U,543,68,1.52015E-89
COG0639,serine threonine-protein phosphatase,T,393,66,1.39149E-89
COG1151,Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity),C,336,67,1.21485E-89
COG0796,Provides the (R)-glutamate required for cell wall biosynthesis (By similarity),M,368,64,1.21049E-89
COG1971,Probably functions as a manganese efflux pump (By similarity),S,480,67,8.09003E-90
COG1376,ErfK ybiS ycfS ynhG family protein,S,368,65,6.70938E-90
COG0217,transcriptional regulatory protein,K,429,65,3.19938E-90
COG1344,Flagellin,N,565,65,1.99551E-90
COG1636,DNA integration recombination invertion protein,S,397,65,1.89331E-90
COG0571,"Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)",K,410,67,1.32827E-90
COG2179,had superfamily (subfamily IIIa) phosphatase,R,377,66,6.46714E-91
COG0175,Reduction of activated sulfate into sulfite (By similarity),P,395,65,6.3041E-91
COG0698,Isomerase,G,558,66,5.98318E-91
COG0498,threonine synthase,E,403,68,5.71209E-91
COG1570,"Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)",L,436,67,2.65582E-91
COG0280,phosphate acetyltransferase,C,469,66,1.78742E-91
COG0682,Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity),M,508,70,1.59073E-91
COG2088,Could be involved in septation (By similarity),M,435,66,1.11373E-91
COG0148,Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity),G,434,67,8.60515E-92
NOG06038,domain protein,S,457,67,7.36108E-92
COG1501,"hydrolase, family 31",G,438,67,7.04862E-92
COG0516,"Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)",F,418,76,5.59542E-92
COG2239,Magnesium transporter,P,488,66,4.59406E-92
COG0691,Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity),O,474,67,4.38458E-92
COG1968,Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity),V,525,71,3.39412E-92
COG0668,Mechanosensitive ion channel,M,456,67,3.02381E-92
COG1918,ferrous iron transport protein,P,636,67,2.92272E-92
COG0194,"Essential for recycling GMP and indirectly, cGMP (By similarity)",F,492,67,2.80014E-92
NOG31688,Conserved domain protein,S,312,67,1.27854E-92
COG1894,Nadh dehydrogenase,C,420,70,8.25852E-93
COG0612,peptidase',O,589,68,7.34148E-93
COG1012,Dehydrogenase,C,552,71,6.57703E-93
COG2826,transposase,L,553,70,4.52313E-93
COG5295,domain protein,U,346,67,3.96426E-93
COG0030,Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity),J,468,69,2.6607E-93
COG0232,deoxyguanosinetriphosphate triphosphohydrolase-like protein,F,499,69,1.47992E-93
COG1208,nucleotidyl transferase,M,377,71,4.56857E-94
COG4166,"Extracellular solute-binding protein, family 5",E,429,69,4.19303E-94
COG0103,30S ribosomal protein S9,J,464,69,3.72963E-94
COG1898,"DTDP-4-dehydrorhamnose 3,5-epimerase",M,441,68,3.53434E-94
COG0809,Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity),J,470,68,3.39196E-94
COG0017,asparaginyl-tRNA synthetase,J,546,69,3.12954E-94
COG0551,"Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)",L,477,69,1.51527E-94
COG0042,Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity),J,569,69,7.45348E-95
COG0053,cation diffusion facilitator family transporter,P,513,75,4.70066E-95
COG1876,Carboxypeptidase,M,517,80,4.36639E-95
COG4496,"protein, YerC YecD",S,430,70,2.86135E-95
COG0034,glutamine phosphoribosylpyrophosphate amidotransferase,F,438,71,1.78825E-95
COG0423,Catalyzes the attachment of glycine to tRNA(Gly) (By similarity),J,500,71,1.34761E-95
COG0044,Dihydroorotase,F,412,69,1.25052E-95
COG0244,50s ribosomal protein L10,J,523,78,1.02551E-95
COG1134,(ABC) transporter,G,515,70,8.5029E-96
COG0238,"Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)",J,358,71,8.19155E-96
COG2385,SpoIID LytB domain protein,D,544,71,7.92765E-96
COG1327,Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity),K,358,70,4.62744E-96
COG1802,GntR Family Transcriptional Regulator,K,442,73,3.55588E-96
COG0779,Required for maturation of 30S ribosomal subunits (By similarity),S,531,70,2.91884E-96
COG0482,"Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)",J,466,70,2.84904E-96
NOG03878,Antirestriction protein,S,462,73,1.53137E-96
COG0166,phosphohexose isomerase,G,502,71,7.88296E-97
COG1004,Udp-glucose 6-dehydrogenase,M,437,71,6.85482E-97
COG0664,"transcriptional regulator, crp fnr family",T,676,74,5.22001E-97
COG0202,DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity),K,587,70,4.14378E-97
COG0144,nOP2 Sun,J,513,70,2.13462E-97
COG1045,serine acetyltransferase,E,549,72,1.141E-97
NOG03632,(ABC) transporter,R,497,78,8.8852E-98
COG0590,deaminase,F,505,75,7.33352E-98
COG1349,transcriptional regulator DeoR family,K,651,72,7.25449E-98
COG0119,Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity),E,537,71,7.10557E-98
COG1799,"Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)",S,362,73,7.0891E-98
COG2984,(ABC) transporter,R,499,72,4.82679E-98
COG0671,PHOsphatase,I,607,74,2.43842E-98
COG3773,Cell wall hydrolase,M,493,71,2.20135E-98
COG1216,"Glycosyl transferase, family 2",M,462,72,1.29806E-98
COG1219,ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity),O,602,74,1.08344E-98
COG0195,Transcription elongation factor NusA,K,531,72,1.01776E-98
COG0258,"Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA (By similarity)",L,577,72,9.2337E-99
NOG51518,Stage v sporulation protein ac,S,474,75,7.9409E-99
COG0099,"Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits",J,495,74,6.2989E-99
COG0533,Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity),O,580,72,2.3058E-99
COG0328,Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity),L,406,74,1.9142E-99
NOG00972,mucin-desulfating sulfatase,S,541,73,1.5794E-99
COG0592,"DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)",L,613,73,1.156E-99
COG1521,"Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)",K,419,75,3.8081E-100
COG3859,Proton-coupled thiamine transporter YuaJ,S,302,77,3.7672E-100
COG2059,Chromate,P,631,73,2.9699E-100
COG0081,"Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)",J,505,88,2.3109E-100
COG1301,sodium dicarboxylate symporter,C,466,73,1.4937E-100
COG0492,thioredoxin reductase,O,554,73,8.4835E-101
COG0079,Imidazole acetol-phosphate transaminase,E,441,76,3.7064E-101
COG0619,Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity),P,482,74,3.6752E-101
COG0443,heat shock protein 70,O,646,73,3.3436E-101
COG1190,lysyl-trna synthetase,J,634,77,2.7567E-101
COG1403,HNH endonuclease,V,333,73,2.3825E-101
COG0787,Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity),M,534,77,2.3449E-101
COG1217,gtp-binding protein typa,T,556,73,1.5069E-101
COG1979,alcohol dehydrogenase,C,384,77,8.22E-102
COG0122,Glycosylase,L,445,76,7.0456E-102
COG1088,dTDP-glucose 4-6-dehydratase,M,473,74,3.8854E-102
COG0528,Catalyzes the reversible phosphorylation of UMP to UDP (By similarity),F,501,78,3.8599E-102
COG1185,Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity),J,536,74,2.917E-102
COG0318,Amp-dependent synthetase and ligase,I,490,74,2.4437E-102
NOG00018,Spore germination protein,S,490,74,2.1633E-102
COG0599,Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity),S,331,75,1.8679E-102
COG0060,"amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)",J,532,76,1.7458E-102
COG1453,Aldo keto reductase,C,496,78,1.0242E-102
COG0394,PHOsphatase,T,646,74,8.5079E-103
COG0058,"Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)",G,513,75,8.6408E-104
COG3682,"transcriptional repressor, copy family",K,444,80,3.8027E-104
COG1682,Abc-2 type transporter,V,526,76,3.5536E-104
COG1164,Oligoendopeptidase f,E,518,78,9.1298E-105
COG3580,coA-substrate-specific enzyme activase,I,483,77,7.8838E-105
COG4584,Transposase,L,470,80,6.3714E-105
COG0539,thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity),J,628,76,6.3106E-105
COG3845,(ABC) transporter,R,635,77,4.4084E-105
COG1757,Na H antiporter,C,553,76,1.9341E-105
COG1905,Nadh dehydrogenase,C,498,79,1.9141E-105
COG1263,PTS System,G,544,82,1.4688E-105
COG0442,"Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)",J,572,80,7.071E-106
COG0272,DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity),L,598,77,2.008E-106
COG1129,(ABC) transporter,P,718,80,1.2687E-106
COG0715,(ABC) transporter,P,584,77,1.1913E-106
COG0322,The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity),L,534,78,1.0385E-106
COG0468,"Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)",L,543,78,1.0154E-106
COG0667,Aldo keto reductase,C,537,82,5.4877E-107
COG1408,metallophosphoesterase,R,487,78,5.1802E-107
COG0613,PHP domain protein,S,548,78,4.578E-107
COG0071,Heat shock protein,O,712,79,4.1799E-107
COG0812,cell wall formation (By similarity),M,461,77,4.0145E-107
COG0574,pyruvate phosphate dikinase,G,523,81,3.6832E-107
COG0102,"This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)",J,472,78,3.135E-107
COG3764,(sortase) family,M,610,78,2.2788E-107
COG1235,domain protein,R,524,78,1.4654E-107
COG1293,Fibronectin-binding A domain protein,K,416,81,1.294E-107
COG0462,Phosphoribosyl pyrophosphate synthase,F,506,81,1.113E-107
COG0558,cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase,I,511,79,7.1623E-108
COG0204,Acyltransferase,I,604,79,6.7178E-108
COG0084,tatd family,L,565,79,5.4778E-108
COG0495,Leucyl-trna synthetase,J,552,79,5.0204E-108
COG0088,"One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)",J,417,78,2.7261E-108
COG0028,acetolactate synthase,E,498,84,2.7064E-108
COG1321,"iron (metal) dependent repressor, dtxr family",K,595,89,2.249E-108
COG2759,formyltetrahydrofolate synthetase,F,509,79,2.0578E-108
COG0679,Auxin Efflux Carrier,R,648,79,1.5924E-108
COG0126,phosphoglycerate kinase,G,542,80,1.4177E-108
COG0637,HAD-superfamily hydrolase subfamily IA variant 3,R,639,79,7.8444E-109
COG0052,30S ribosomal protein S2,J,499,82,7.8238E-109
COG2188,GntR family transcriptional regulator,K,466,80,3.8129E-109
COG1488,Nicotinate phosphoribosyltransferase,H,441,80,2.4658E-109
COG0614,Periplasmic binding protein,P,562,82,2.137E-109
NOG00382,[NoAnn],S,481,82,1.247E-109
COG0275,Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity),M,645,80,8.9173E-110
COG0652,PPIases accelerate the folding of proteins,O,571,81,5.3889E-110
COG0317,In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity),K,589,82,2.8206E-110
COG0172,"Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)",J,559,82,1.2583E-110
COG0749,DNA polymerase,L,614,82,1.1617E-110
COG1473,amidohydrolase,E,705,80,1.0934E-110
COG1737,Transcriptional regulator,K,693,84,8.7981E-111
COG0057,glyceraldehyde3phosphate dehydrogenase,G,504,80,6.9984E-111
COG0124,Histidyl-trna synthetase,J,551,81,3.8183E-111
COG2357,relA SpoT domain protein,S,501,81,3.0998E-111
COG0226,phosphate abc transporter,P,446,83,4.2139E-112
COG5412,Tape measure protein,S,563,82,4.042E-112
COG0822,"sUF system Fes assembly protein, NifU family",C,671,95,3.0068E-112
COG2176,Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity),L,644,85,1.9382E-112
COG2873,o-acetylhomoserine,E,467,82,1.7094E-112
COG4804,Conserved protein,S,651,87,1.424E-112
COG0002,N-acetylglutamate semialdehyde dehydrogenase,E,268,86,1.144E-112
COG3475,licD family,M,496,83,7.0491E-113
COG3968,glutamine synthetase,E,459,86,5.1711E-113
COG1283,Na Pi-cotransporter,P,707,86,3.3232E-113
COG1179,uba thif-type nad fad binding protein,H,509,85,3.126E-113
COG0484,"ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)",O,617,82,2.7469E-113
COG0193,The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity),J,475,84,2.5223E-113
COG1362,M18 family aminopeptidase,E,611,87,1.2069E-113
COG3328,transposase,L,516,87,1.1865E-113
COG0771,Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity),M,516,83,1.0963E-113
COG1296,AzlC Family,E,446,82,5.6502E-114
COG1002,"Type II restriction enzyme, methylase",V,481,84,3.8441E-114
COG0469,Pyruvate kinase,G,503,92,2.5783E-114
COG2081,hi0933 family,R,578,84,2.449E-114
COG0481,"Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)",M,558,86,1.1833E-114
NOG65634,Sporulation transcriptional regulator spoiiid,K,459,85,9.7044E-115
COG1409,"Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)",R,590,89,5.6679E-115
COG3943,"Toxin-antitoxin system, toxin component, Fic family",S,761,85,4.724E-115
COG1597,diacylglycerol kinase,I,621,83,3.3252E-115
COG1209,"Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)",M,415,89,1.9188E-115
COG1073,Hydrolase,R,715,89,1.8952E-115
COG1187,Pseudouridine synthase,J,676,86,1.2244E-115
COG0491,Beta-lactamase domain protein,R,763,85,1.195E-115
COG0591,symporter,E,558,84,9.5419E-116
COG0329,Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity),E,672,84,4.0794E-116
COG0472,First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity),M,644,94,3.7316E-116
COG1200,ATP-dependent DNA helicase recG,L,484,85,2.8195E-116
COG0770,Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity),M,432,88,2.0531E-116
NOG01848,Plasmid recombination enzyme,S,570,84,1.7889E-116
COG1368,Sulfatase,M,639,87,1.5678E-116
COG4260,virion core protein (Lumpy skin disease,S,594,88,1.5384E-116
COG0622,"Phosphodiesterase, mj0936 family",R,540,87,1.413E-116
COG4608,(ABC) transporter,E,591,86,1.2155E-116
COG0426,domain protein,C,564,86,8.1686E-117
COG5279,domain protein,D,537,88,3.6808E-117
COG0104,Plays an important role in the de novo pathway of purine nucleotide biosynthesis,F,519,88,2.8355E-117
COG0448,"Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)",G,684,87,3.2875E-118
COG0018,arginyL-tRNA synthetase,J,544,87,3.0889E-118
COG1180,activating enzyme,O,645,89,9.7372E-119
COG0234,Binds to cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity),O,520,93,6.5801E-119
COG1638,"Trap dicarboxylate transporter, dctp subunit",G,449,87,1.9376E-119
COG0012,gtp-binding protein,J,562,89,1.609E-119
COG2110,appr-1-p processing domain protein,R,749,91,5.8631E-120
COG0171,nh(3)-dependent nad( ) synthetase,H,455,91,5.8435E-120
COG0137,Citrulline--aspartate ligase,E,362,94,5.766E-120
COG1077,"Rod shape-determining protein, MreB",D,692,87,3.3769E-120
COG1181,Cell wall formation (By similarity),M,579,92,8.8857E-121
COG3645,Antirepressor,K,605,93,2.1817E-121
COG0192,Catalyzes the formation of S-adenosylmethionine from methionine and ATP,H,794,90,3.463E-122
COG0596,Alpha beta hydrolase,R,596,91,2.2485E-122
COG3601,Membrane,S,350,89,1.8165E-122
COG0231,"Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)",J,508,94,1.3771E-122
COG0330,Band 7 protein,O,632,90,3.5334E-123
COG1063,Dehydrogenase,C,641,91,8.53E-124
COG0206,Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity),D,522,97,5.2897E-124
COG2606,YbaK ebsC protein,S,586,94,2.485E-124
COG3378,"phage plasmid primase, p4 family",R,685,96,1.4323E-124
COG2184,cell filamentation protein,D,474,91,1.383E-124
NOG02831,ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity),S,505,91,5.6736E-125
COG1924,coA-substrate-specific enzyme activase,I,590,92,5.4368E-125
COG0162,Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity),J,519,91,4.2618E-125
COG0733,Transporter,P,704,95,4.2006E-125
COG3481,Metal Dependent Phosphohydrolase,R,605,91,2.6272E-125
COG3842,Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity),E,584,91,1.3809E-125
COG0466,"ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)",O,543,96,6.7224E-126
COG2233,permease,F,636,92,3.027E-126
COG1195,"it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)",L,559,93,2.4304E-126
COG0608,Single-stranded-DNA-specific exonuclease (RecJ),L,577,92,1.6556E-126
COG1917,Cupin 2 Conserved Barrel Domain Protein,S,559,93,7.3866E-127
COG0503,"Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)",F,738,98,1.5298E-127
COG0840,Methyl-accepting chemotaxis,N,562,101,4.6583E-128
COG0489,ATP-binding protein,D,686,95,1.9239E-128
COG1323,UPF0348 protein,S,541,96,1.4844E-128
COG0526,Thioredoxin,O,587,98,6.1276E-129
COG0556,"damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)",L,642,99,4.1231E-129
COG0610,Type I site-specific deoxyribonuclease,V,730,96,3.2983E-129
COG0143,Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity),J,631,94,2.2705E-129
COG0006,peptidase M24,E,592,95,3.6102E-130
COG1253,CBS Domain protein,P,691,101,3.2137E-130
COG1387,"histidinol phosphate phosphatase, hisj family",E,608,98,1.3041E-130
COG0769,Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity),M,755,102,9.8198E-131
COG2256,Recombination factor protein RarA,L,645,98,3.0102E-131
COG0520,cysteine desulfurase,E,589,98,2.9599E-131
COG0178,"The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)",L,741,99,1.6832E-131
COG0747,"Extracellular solute-binding protein, family 5",E,758,101,2.1461E-132
COG0180,tryptophanyltRNA synthetase,J,620,96,1.5501E-132
COG1092,Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity),R,704,100,1.0836E-132
COG0587,DNA polymerase III (alpha subunit),L,697,98,1.8906E-133
COG0242,Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity),J,618,97,1.4845E-133
COG0087,"One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)",J,523,97,7.7408E-134
COG0249,that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity),L,650,100,3.3392E-134
COG1882,formate acetyltransferase,C,600,101,1.2109E-134
COG0346,glyoxalase bleomycin resistance protein dioxygenase,E,504,101,1.0557E-134
COG0640,"Transcriptional regulator, arsr family",K,863,106,1.0067E-134
COG0543,Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity),C,622,99,8.9904E-135
COG2211,Transporter,G,583,100,5.8803E-135
COG0085,DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity),K,555,100,4.646E-135
COG4974,"Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)",L,732,106,6.9834E-136
COG2509,fad dependent oxidoreductase,R,683,103,2.111E-137
COG0593,it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity),L,617,104,1.1142E-137
COG4626,"Terminase, large subunit",R,723,112,1.6342E-138
COG0334,glutamate dehydrogenase,E,473,113,1.4281E-138
NOG01346,conjugative transposon membrane protein,S,734,103,1.2399E-138
COG0338,Dna adenine methylase,L,797,103,4.4934E-139
COG0784,response regulator,T,824,105,2.4214E-139
COG1126,"ABC transporter, (ATP-binding protein)",E,948,103,1.3032E-139
COG0657,alpha beta hydrolase fold-3 domain protein,I,750,103,6.6134E-140
COG2003,DNA repair protein (RadC,L,642,107,1.8961E-140
COG3436,Transposase,L,824,104,1.1683E-140
COG2199,Diguanylate cyclase,T,668,105,9.9228E-141
COG1160,GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity),R,634,106,7.8433E-141
COG0441,Threonyl-trna synthetase,J,840,109,3.3231E-141
COG0628,Membrane,S,791,107,3.4904E-142
COG2189,DNA Methylase,L,742,105,2.781E-142
COG1082,Xylose isomerase domain protein TIM barrel,G,708,104,5.262E-143
COG0602,"Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)",O,792,105,4.5553E-143
COG5263,cell wall binding,R,661,111,3.6153E-143
COG3617,Antirepressor,K,667,110,4.5679E-144
COG1011,Hydrolase,R,632,110,3.2411E-144
COG0444,(ABC) transporter,E,733,106,2.494E-144
COG0031,cysteine synthase,E,631,106,1.1896E-144
NOG02827,ATPase (AAA,S,729,106,9.6824E-145
COG0420,Exonuclease,L,497,109,4.0539E-145
COG0750,Membrane-associated zinc metalloprotease,M,801,107,2.5774E-145
COG0635,Coproporphyrinogen III oxidase,H,776,107,6.428E-146
COG1744,basic membrane,R,784,108,4.413E-146
COG0790,Sel1 domain protein repeat-containing protein,R,891,107,2.4534E-146
COG2508,Transcriptional regulator,K,771,107,1.4415E-146
COG0714,ATPase associated with various cellular activities,R,635,108,7.9253E-147
COG0656,reductase,R,507,113,2.7335E-147
COG0773,Cell wall formation (By similarity),M,503,115,1.4642E-148
COG1733,Transcriptional regulator,K,621,109,4.3198E-149
COG0765,amino acid AbC transporter,E,1034,111,2.9872E-150
COG0515,Serine Threonine protein kinase,T,895,115,1.7988E-150
COG4646,helicase,L,852,115,1.701E-150
COG4905,membrane,S,772,114,7.3351E-151
COG0446,pyridine nucleotide-disulfide oxidoreductase,C,994,115,4.9941E-151
COG0653,"Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving",U,673,112,3.5611E-151
COG0568,Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity),K,754,111,2.4174E-151
COG0305,Replicative dna helicase,L,749,119,9.2275E-152
COG0826,Peptidase U32,O,926,111,4.9482E-152
COG0569,Potassium uptake protein,P,756,113,3.1066E-152
COG0358,DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity),L,872,120,2.2352E-153
COG0778,nitroreductase,C,938,118,1.7782E-153
COG0782,"Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)",K,643,116,5.1638E-154
COG0471,Transporter,P,674,115,4.5018E-154
COG0517,"Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)",R,777,122,3.1977E-154
COG0406,Phosphoglycerate mutase,G,790,113,1.5708E-154
COG2195,Cleaves the N-terminal amino acid of tripeptides (By similarity),E,668,118,1.736E-155
COG2801,Retrotransposon protein,L,767,116,3.437E-156
COG0188,"DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)",L,872,116,1.464E-157
COG1173,ABC transporter (Permease,P,731,116,1.3112E-158
COG1302,alkaline shock protein,S,648,124,7.4014E-159
COG0546,"had-superfamily hydrolase, subfamily ia, variant",R,911,119,4.3247E-159
COG0111,Dehydrogenase,E,714,119,9.1633E-161
COG1696,Membrane bOund o-acyl transferase mboat family protein,M,925,120,2.3701E-161
COG0577,ABC transporter (permease),V,1004,124,1.3096E-162
COG0399,DegT DnrJ EryC1 StrS aminotransferase,E,744,119,4.3325E-163
COG0493,glutamate synthase,E,900,120,1.7488E-164
COG1674,cell division protein FtsK,D,821,124,1.1154E-164
COG0168,Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity),P,793,122,5.9661E-165
COG0454,acetyltransferase,K,920,125,4.9513E-165
COG0863,DNA methylase n-4 n-6 domain protein,L,961,136,2.0409E-165
COG0624,"Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)",E,752,126,1.5105E-165
NOG00011,Histidine kinase,T,882,127,1.0179E-165
COG1316,transcriptional,K,914,122,1.9436E-166
COG0535,radical SAM domain protein,R,873,123,1.29E-166
COG1061,type iii restriction protein res subunit,L,746,126,4.0535E-167
COG1484,IstB domain protein ATP-binding protein,L,1008,126,2.2986E-167
COG0726,polysaccharide deacetylase,G,1090,130,2.4279E-168
COG0388,nitrilase cyanide hydratase and apolipoprotein n-acyltransferase,R,737,132,1.4239E-169
COG0265,serine protease,O,872,124,1.5532E-170
COG1404,"peptidase (S8 and S53, subtilisin, kexin, sedolisin",O,789,127,6.987E-171
COG0641,radical SAM domain protein,R,836,127,2.5803E-171
COG1670,acetyltransferase,J,899,126,2.1246E-171
COG1328,Anaerobic ribonucleoside-triphosphate reductase,F,904,137,1.3014E-171
COG0697,membrane,E,879,129,7.2633E-173
COG1940,ROK family,G,932,131,3.8281E-173
COG1013,Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity),C,722,136,2.651E-173
COG1070,Carbohydrate kinase,G,881,127,2.5568E-173
COG0553,helicase,L,934,133,1.7648E-173
COG1472,hydrolase family 3,G,1126,132,1.2369E-173
COG2333,DNA internalization-related competence protein ComEC Rec2,R,897,140,1.168E-173
COG1032,radical SAM domain protein,C,974,129,4.8514E-174
COG0428,zinc transporter,P,660,130,4.0586E-174
COG0542,ATP-dependent CLP protease ATP-binding subunit,O,1166,131,1.1531E-176
COG1725,Transcriptional regulator GntR family,K,857,130,7.1854E-177
COG0744,penicillin-binding protein,M,747,134,2.539E-177
COG4209,Binding-protein-dependent transport systems inner membrane component,G,1014,133,2.3247E-177
COG3757,"hydrolase, family 25",M,911,132,9.5834E-178
COG0544,Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation,O,836,132,4.7393E-178
COG0037,"Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)",D,1123,140,5.0962E-180
COG0756,"This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)",F,917,134,4.449E-180
COG0791,NLP P60 protein,M,1022,137,3.2488E-180
COG1959,"Transcriptional regulator, BadM Rrf2 family",K,764,140,2.4853E-180
COG0360,Binds together with S18 to 16S ribosomal RNA (By similarity),J,504,138,3.9812E-181
COG0674,Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity),C,776,144,6.2591E-184
COG0191,Aldolase,G,814,138,2.5439E-184
COG3839,(ABC) transporter,G,766,139,4.3962E-185
COG1115,amino acid carrier protein,E,883,136,8.1285E-186
COG0210,helicase,L,1114,138,3.3447E-186
COG0601,ABC transporter (permease),P,927,141,3.2576E-187
COG0740,Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity),O,1150,142,2.1814E-188
COG2002,Transcriptional regulator AbrB family,K,1107,150,1.1967E-188
COG1145,"4Fe-4S ferredoxin, iron-sulfur binding",C,945,159,8.42E-189
COG2812,dna polymerase iii subunits gamma and tau,L,884,138,8.3561E-189
COG1695,Transcriptional regulator,K,730,141,4.5181E-189
COG0507,exodeoxyribonuclease v alpha,L,1221,139,1.5853E-189
COG0827,DNA Methylase,L,1027,145,8.1507E-191
COG0451,Nad-dependent epimerase dehydratase,M,1039,144,5.2046E-191
COG1014,oxidoreductase,C,822,153,3.3567E-192
COG0187,"DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)",L,1012,144,3.4397E-193
NOG00179,[NoAnn],S,781,141,1.8913E-193
COG1104,cysteine desulfurase,E,1069,152,4.0986E-194
COG0008,Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity),J,1074,143,1.5744E-194
COG0707,Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity),M,836,153,1.9312E-197
COG2865,Transcriptional regulator,K,1061,149,1.0444E-197
COG0500,methyltransferase,Q,1243,150,9.3213E-198
COG2265,catalyzes the formation of 5-methyl-uridine at position,J,1010,146,1.4553E-198
COG0480,"Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)",J,1115,148,7.2984E-199
COG3655,Transcriptional regulator,K,920,157,4.3163E-199
COG0449,"Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)",M,761,153,2.7121E-199
COG1284,membrane,S,1093,154,2.3317E-199
COG0789,Transcriptional regulator,K,937,151,1.7145E-200
COG3843,relaxase Mobilization nuclease domain protein,U,1345,150,4.5678E-202
COG0673,oxidoreductase,R,1058,149,2.0797E-202
NOG07089,"Two component transcriptional regulator, winged helix family",T,1056,155,4.1933E-204
COG0595,Metallo-Beta-Lactamase,R,643,167,1.2522E-204
COG0465,"Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)",O,1049,161,5.0025E-205
COG1592,Rubrerythrin,C,1073,156,1.2585E-206
COG1853,"flavin reductase domain protein, FMN-binding",R,935,155,8.108E-208
COG0766,Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity),M,895,157,4.7408E-208
COG3250,hydrolase family 2,G,1102,161,1.2806E-208
COG1028,short-chain dehydrogenase reductase,I,1072,159,5.2645E-209
COG1418,Endoribonuclease that initiates mRNA decay (By similarity),R,945,154,3.3741E-209
COG0566,methyltransferase,J,1155,158,4.6765E-210
COG1167,"Transcriptional regulator, gntR family",K,884,158,3.664E-212
COG0073,Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity),J,1357,160,3.8054E-213
COG4509,"sortase, SrtB family",S,999,156,2.1749E-213
COG1943,transposase,L,766,173,6.0805E-214
COG0768,penicillin-binding protein,M,1333,164,1.3549E-215
COG4624,hydrogenase,C,1013,161,4.4351E-217
COG0564,Pseudouridine synthase,J,1550,160,3.8986E-217
COG0205,phosphohexokinase,G,1016,162,2.7656E-217
COG3209,YD repeat protein,M,1193,169,4.2553E-220
COG0474,P-type atpase,P,1051,168,2.0855E-221
COG0370,Ferrous iron transport protein b,P,1164,171,2.3449E-223
COG2337,Toxic component of a toxin-antitoxin (TA) module (By similarity),T,1030,168,1.1401E-226
COG0772,Cell Division Protein,D,1151,178,4.701E-229
COG1454,alcohol dehydrogenase,C,1182,173,3.4133E-230
COG0860,n-acetylmuramoyl-l-alanine amidase,M,1380,180,5.8169E-231
COG0524,pfkb domain protein,G,1109,173,1.0757E-231
COG0681,Signal peptidase i,U,1227,171,1.2204E-232
COG0366,"alpha amylase, catalytic",G,1347,188,4.2827E-235
COG0655,Nadph-dependent fmn reductase,R,1002,181,1.8328E-238
COG0561,",hydrolase",R,1337,192,3.4497E-241
NOG05542,integrase family,L,1657,180,3.3218E-242
COG1175,binding-protein-dependent transport systems inner membrane Component,P,1470,187,7.5956E-243
COG3344,RNA-directed DNA polymerase,L,1279,181,2.566E-245
COG0389,Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity),L,1173,183,3.1533E-246
COG0550,"Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)",L,1331,188,2.3976E-248
COG1122,(ABC) transporter,P,1299,184,1.4137E-248
COG0436,aminotransferase,E,1307,192,8.0717E-249
COG0110,acetyltransferase,R,1346,193,1.0206E-254
COG3177,Filamentation induced by cAMP protein fic,S,1186,188,9.5304E-256
COG2148,sugar transferase,M,1293,197,2.6503E-268
COG0716,Low-potential electron donor to a number of redox enzymes (By similarity),C,1151,200,4.3981E-271
COG1974,"Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)",K,1363,221,3.526E-274
COG0395,Binding-protein-dependent transport systems inner membrane component,G,1809,210,2.481E-275
COG5492,ig domain protein group 2 domain protein,N,1515,209,4.2147E-278
COG4932,domain protein,M,1211,215,2.3218E-279
COG1309,Transcriptional regulator,K,1310,210,6.7359E-280
COG3547,Transposase,L,916,233,3.317E-286
COG0488,(ABC) transporter,R,1395,220,1.1121E-290
COG1686,Carboxypeptidase,M,1658,217,9.2672E-291
COG1109,Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity),G,1397,215,3.0358E-291
COG0834,(ABC) transporter,E,1384,231,1.1007E-291
COG2244,Polysaccharide biosynthesis protein,M,1506,224,4.869E-292
COG1192,"cobyrinic Acid a,c-diamide synthase",D,1920,220,2.0469E-292
COG1609,Transcriptional regulator,K,1518,220,1.6598E-292
COG1307,degv family,S,1581,224,1.6148E-292
COG0739,peptidase',M,1782,224,2.0673E-295
COG0621,"Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)",J,1419,224,1.7069E-296
NOG00044,(ABC) transporter,V,1706,221,6.1071E-297
COG4753,Transcriptional regulator (AraC family),T,1668,224,5.0246E-297
COG1595,RNA Polymerase,K,1843,254,0
COG3279,regulator,T,1856,290,0
COG0286,type I restriction-modification system,V,1601,240,0
COG0494,NUDiX hydrolase,L,1874,260,0
COG2972,Histidine kinase,T,1858,250,0
COG1191,Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity),K,1847,233,0
COG1136,(ABC) transporter,V,1769,304,0
NOG02992,surface antigen,S,1879,250,0
COG1373,ATPase (AAA,R,2393,307,0
COG0583,Transcriptional regulator,K,2626,457,0
COG3505,trag family,U,2255,290,0
COG0270,Cytosine-specific methyltransferase,L,2330,379,0
COG0642,Histidine kinase,T,2315,366,0
COG3451,type IV secretion system protein,U,1770,269,0
COG0745,regulatoR,T,2899,404,0
COG1475,parb-like partition protein,K,2714,344,0
COG1653,extracellular solute-binding protein family 1,G,1838,250,0
COG0438,Glycosyl transferase (Group 1,M,1964,312,0
COG1131,(ABC) transporter,V,2317,353,0
COG0629,single-stranded DNA-binding protein,L,1888,318,0
COG1396,Transcriptional regulator,K,1967,305,0
COG2207,"Transcriptional regulator, ARAC family",K,2574,420,0
COG0732,restriction modification system DNA specificity,V,1675,249,0
COG1132,(ABC) transporter,V,3378,453,0
COG0463,"Glycosyl transferase, family 2",M,3247,514,0
COG0534,Mate efflux family protein,V,5381,781,0
COG0582,Integrase,L,5870,805,0
COG1961,Resolvase,L,8951,1284,0
NOG101249,Transcriptional regulator,K,3755,682,0