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{"sheet":"Table S6.1","index":0,"n_rows":21,"n_cols":2,"rows_kept":21,"cut":false,"hidden":false,"merged":[]}
["S6.1 Table. The primers used for qRT-PCR verification."]
["miRNAs","Primers"]
["U6 snRNA-F","GCTTCGGCAGCACATATACTAAAAT"]
["U6 snRNA-R","CGCTTCACGAATTTGCGTGTCAT"]
["miR156a,b,c,d,e,f,g,l-5p","GCCGTGACAGAAGAGAGTGAGCA"]
["miR159a,f-3p","GCTTTGGATTGAAGGGAGCTCTG"]
["miR159c_L-1R-1-3p","GGCGATTGGATTGAAGGGAGC"]
["miR166b,d,e,g,h,i-3p","GGCTCGGACCAGGCTTCATTC"]
["miR167g_R+1,h_R+1,i_R+1-5p","GGTGAAGCTGCCAGCATGATCT"]
["miR167g_L+1-3p ","CCGCAGGTCATGCTGTAGTTTCA"]
["miR169o_R-1-5p","CGCTAGCCAAGAATGACTTGCCT"]
["miR171c_1ss4CT,d,e,n_R+1_1ss12CT-3p","GGTGATTGAGCCGTGCCAATATC"]
["miR319a_R+1,b_R+1,c_R+1,d_R+1-3p","CGGTTGGACTGAAGGGTGCTC"]
["miR396a,b-5p","GCCCTTCCACAGCTTTCTTGAACT"]
["miR396c_L-1","CGCTCCACAGGCTTTCTTGAACT"]
["miR408a_R+3","TCTGCACTGCCTCTTCCCTGG"]
["miR444a_1ss12TC,b_1ss12TC","CCATGCAGTTGTTGCCTCAAGC"]
["miR827_R-1-3p","CCGCTTAGATGACCATCAGCAAAC"]
["PC-5p-1983_455","GCGGTAGGTCTTGTTTGGCTGC"]
["PC-5p-6152_162","GCCGTTTGTTAATGTTTGGAGTAGC"]
["PC-5p-9399_103","GCCCTTTGGAACTTTGGCACTC"]

{"sheet":"Table S6.2","index":1,"n_rows":55,"n_cols":11,"rows_kept":55,"cut":false,"hidden":false,"merged":[[0,0,0,10],[1,6,3,6],[1,7,3,7],[1,8,3,8],[1,9,3,9],[1,10,3,10]]}
["S6.2 Table. qRT-PCR verification of miRNAs in the PH6WC and PH4CV lines."]
["U6 snRNA","Ct1","Ct2","Ct3","Average Ct","SD","-","-","-","-","-"]
["PH6WC",19.93,19.95,19.94,{"$f":"AVERAGE(B3:D3)","v":19.94},{"$f":"STDEV(B3:D3)","v":0.00999999999999979}]
["PH4CV",20.59,20.4,20.51,{"$f":"AVERAGE(B4:D4)","v":20.5},{"$f":"STDEV(B4:D4)","v":0.0953939201416953}]
["zma-miR166b,d,e,g,h,i-3p","Ct1","Ct2","Ct3","Average Ct","SD","⊿Ct","⊿⊿Ct","2(-⊿⊿Ct)","2(-(⊿⊿Ct+SD))","2(-(⊿⊿Ct-SD))"]
["PH6WC",18.24,18.52,18.47,{"$f":"AVERAGE(B6:D6)","v":18.41},{"$f":"STDEV(B6:D6)","v":0.149331845230681},{"$f":"E6-E3","v":-1.53},0,{"$f":"POWER(2,-H6)","v":1},{"$f":"POWER(2,-(H6+F6))","v":0.901667955041238},{"$f":"POWER(2,-(H6-F6))","v":1.10905571658501}]
["PH4CV",18.88,18.89,18.88,{"$f":"AVERAGE(B7:D7)","v":18.8833333333333},{"$f":"STDEV(B7:D7)","v":0.00577350269189716},{"$f":"E7-E4","v":-1.61666666666667},{"$f":"G7-G6","v":-0.0866666666666731},{"$f":"POWER(2,-H7)","v":1.06191380396236},{"$f":"POWER(2,-(H7+F7))","v":1.05767263679168},{"$f":"POWER(2,-(H7-F7))","v":1.06617197781199}]
["zma-miR156a,b,c,d,e,f,g,l-5p","Ct1","Ct2","Ct3","Average Ct","SD","⊿Ct","⊿⊿Ct","2(-⊿⊿Ct)","2(-(⊿⊿Ct+SD))","2(-(⊿⊿Ct-SD))"]
["PH6WC",20.12,20.42,20.26,{"$f":"AVERAGE(B9:D9)","v":20.2666666666667},{"$f":"STDEV(B9:D9)","v":0.150111069989303},{"$f":"E9-E3","v":0.326666666666672},0,{"$f":"POWER(2,-H9)","v":1},{"$f":"POWER(2,-(H9+F9))","v":0.901181079946311},{"$f":"POWER(2,-(H9-F9))","v":1.10965489872421}]
["PH4CV",22.32,22.49,22.42,{"$f":"AVERAGE(B10:D10)","v":22.41},{"$f":"STDEV(B10:D10)","v":0.0854400374531745},{"$f":"E10-E4","v":1.91},{"$f":"G10-G9","v":1.58333333333333},{"$f":"POWER(2,-H10)","v":0.33370996354251},{"$f":"POWER(2,-(H10+F10))","v":0.314520646309271},{"$f":"POWER(2,-(H10-F10))","v":0.354070046193531}]
["zma-miR159a,f-3p","Ct1","Ct2","Ct3","Average Ct","SD","⊿Ct","⊿⊿Ct","2(-⊿⊿Ct)","2(-(⊿⊿Ct+SD))","2(-(⊿⊿Ct-SD))"]
["PH6WC",16.56,16.58,16.56,{"$f":"AVERAGE(B12:D12)","v":16.5666666666667},{"$f":"STDEV(B12:D12)","v":0.0115470053837923},{"$f":"E12-E3","v":-3.37333333333333},0,{"$f":"POWER(2,-H12)","v":1},{"$f":"POWER(2,-(H12+F12))","v":0.992028170691792},{"$f":"POWER(2,-(H12-F12))","v":1.00803589005204}]
["PH4CV",14.34,14.49,14.53,{"$f":"AVERAGE(B13:D13)","v":14.4533333333333},{"$f":"STDEV(B13:D13)","v":0.100166528008778},{"$f":"E13-E4","v":-6.04666666666667},{"$f":"G13-G12","v":-2.67333333333333},{"$f":"POWER(2,-H13)","v":6.37901350714557},{"$f":"POWER(2,-(H13+F13))","v":5.9511430849364},{"$f":"POWER(2,-(H13-F13))","v":6.83764660731231}]
["zma-miR159c_L-1R-1-3p","Ct1","Ct2","Ct3","Average Ct","SD","⊿Ct","⊿⊿Ct","2(-⊿⊿Ct)","2(-(⊿⊿Ct+SD))","2(-(⊿⊿Ct-SD))"]
["PH6WC",16.68,16.87,16.77,{"$f":"AVERAGE(B15:D15)","v":16.7733333333333},{"$f":"STDEV(B15:D15)","v":0.0950438495292223},{"$f":"E15-E3","v":-3.16666666666667},0,{"$f":"POWER(2,-H15)","v":1},{"$f":"POWER(2,-(H15+F15))","v":0.936243790642032},{"$f":"POWER(2,-(H15-F15))","v":1.06809787151085}]
["PH4CV",13.84,13.74,13.92,{"$f":"AVERAGE(B16:D16)","v":13.8333333333333},{"$f":"STDEV(B16:D16)","v":0.0901849950564577},{"$f":"E16-E4","v":-6.66666666666667},{"$f":"G16-G15","v":-3.49999999999999},{"$f":"POWER(2,-H16)","v":11.3137084989847},{"$f":"POWER(2,-(H16+F16))","v":10.6281235938373},{"$f":"POWER(2,-(H16-F16))","v":12.0435182061882}]
["zma-miR167g_R+1,h_R+1,i_R+1-5p","Ct1","Ct2","Ct3","Average Ct","SD","⊿Ct","⊿⊿Ct","2(-⊿⊿Ct)","2(-(⊿⊿Ct+SD))","2(-(⊿⊿Ct-SD))"]
["PH6WC",14.76,14.86,14.68,{"$f":"AVERAGE(B18:D18)","v":14.7666666666667},{"$f":"STDEV(B18:D18)","v":0.0901849950564577},{"$f":"E18-E3","v":-5.17333333333334},0,{"$f":"POWER(2,-H18)","v":1},{"$f":"POWER(2,-(H18+F18))","v":0.939402283061395},{"$f":"POWER(2,-(H18-F18))","v":1.06450667411742}]
["PH4CV",16.14,16.13,16.14,{"$f":"AVERAGE(B19:D19)","v":16.1366666666667},{"$f":"STDEV(B19:D19)","v":0.00577350269189716},{"$f":"E19-E4","v":-4.36333333333333},{"$f":"G19-G18","v":0.810000000000002},{"$f":"POWER(2,-H19)","v":0.570381857934211},{"$f":"POWER(2,-(H19+F19))","v":0.568103815402325},{"$f":"POWER(2,-(H19-F19))","v":0.572669035201045}]
["zma-miR167g_L+1-3p","Ct1","Ct2","Ct3","Average Ct","SD","⊿Ct","⊿⊿Ct","2(-⊿⊿Ct)","2(-(⊿⊿Ct+SD))","2(-(⊿⊿Ct-SD))"]
["PH6WC",24.76,24.854,24.69,{"$f":"AVERAGE(B21:D21)","v":24.768},{"$f":"STDEV(B21:D21)","v":0.0822921624457628},{"$f":"E21-E3","v":4.828},0,{"$f":"POWER(2,-H21)","v":1},{"$f":"POWER(2,-(H21+F21))","v":0.944555738156615},{"$f":"POWER(2,-(H21-F21))","v":1.05869877192381}]
["PH4CV",25.63,25.46,25.29,{"$f":"AVERAGE(B22:D22)","v":25.46},{"$f":"STDEV(B22:D22)","v":0.17},{"$f":"E22-E4","v":4.96},{"$f":"G22-G21","v":0.132000000000001},{"$f":"POWER(2,-H22)","v":0.912565488543452},{"$f":"POWER(2,-(H22+F22))","v":0.811127155577042},{"$f":"POWER(2,-(H22-F22))","v":1.02668954572}]
["zma-miR169o_R-1-5p","Ct1","Ct2","Ct3","Average Ct","SD","⊿Ct","⊿⊿Ct","2(-⊿⊿Ct)","2(-(⊿⊿Ct+SD))","2(-(⊿⊿Ct-SD))"]
["PH6WC",19.39,19.38,19.37,{"$f":"AVERAGE(B24:D24)","v":19.38},{"$f":"STDEV(B24:D24)","v":0.00999999999999979},{"$f":"E24-E3","v":-0.559999999999999},0,{"$f":"POWER(2,-H24)","v":1},{"$f":"POWER(2,-(H24+F24))","v":0.993092495437036},{"$f":"POWER(2,-(H24-F24))","v":1.00695555005672}]
["PH4CV",21.31,21.25,21.29,{"$f":"AVERAGE(B25:D25)","v":21.2833333333333},{"$f":"STDEV(B25:D25)","v":0.0305505046330383},{"$f":"E25-E4","v":0.783333333333335},{"$f":"G25-G24","v":1.34333333333333},{"$f":"POWER(2,-H25)","v":0.394109017989619},{"$f":"POWER(2,-(H25+F25))","v":0.385851110236841},{"$f":"POWER(2,-(H25-F25))","v":0.402543659821021}]
["zma-miR171c_1ss4CT,d,e,n_R+1_1ss12CT-3p","Ct1","Ct2","Ct3","Average Ct","SD","⊿Ct","⊿⊿Ct","2(-⊿⊿Ct)","2(-(⊿⊿Ct+SD))","2(-(⊿⊿Ct-SD))"]
["PH6WC",22.74,22.15,22.46,{"$f":"AVERAGE(B27:D27)","v":22.45},{"$f":"STDEV(B27:D27)","v":0.295127091267474},{"$f":"E27-E3","v":2.51},0,{"$f":"POWER(2,-H27)","v":1},{"$f":"POWER(2,-(H27+F27))","v":0.815000533435904},{"$f":"POWER(2,-(H27-F27))","v":1.22699306193601}]
["PH4CV",24.07,23.92,24.08,{"$f":"AVERAGE(B28:D28)","v":24.0233333333333},{"$f":"STDEV(B28:D28)","v":0.0896288643983236},{"$f":"E28-E4","v":3.52333333333333},{"$f":"G28-G27","v":1.01333333333333},{"$f":"POWER(2,-H28)","v":0.495400306632616},{"$f":"POWER(2,-(H28+F28))","v":0.465559608597571},{"$f":"POWER(2,-(H28-F28))","v":0.527153686186362}]
["zma-miR319a_R+1,b_R+1,c_R+1,d_R+1-3p","Ct1","Ct2","Ct3","Average Ct","SD","⊿Ct","⊿⊿Ct","2(-⊿⊿Ct)","2(-(⊿⊿Ct+SD))","2(-(⊿⊿Ct-SD))"]
["PH6WC",20.21,20.42,20.31,{"$f":"AVERAGE(B30:D30)","v":20.3133333333333},{"$f":"STDEV(B30:D30)","v":0.105039675043925},{"$f":"E30-E3","v":0.373333333333331},0,{"$f":"POWER(2,-H30)","v":1},{"$f":"POWER(2,-(H30+F30))","v":0.929779372729265},{"$f":"POWER(2,-(H30-F30))","v":1.07552396765333}]
["PH4CV",17.44,16.85,16.97,{"$f":"AVERAGE(B31:D31)","v":17.0866666666667},{"$f":"STDEV(B31:D31)","v":0.31182259913825},{"$f":"E31-E4","v":-3.41333333333333},{"$f":"G31-G30","v":-3.78666666666666},{"$f":"POWER(2,-H31)","v":13.800672511875},{"$f":"POWER(2,-(H31+F31))","v":11.1181439986168},{"$f":"POWER(2,-(H31-F31))","v":17.1304276868259}]
["zma-miR396a,b-5p","Ct1","Ct2","Ct3","Average Ct","SD","⊿Ct","⊿⊿Ct","2(-⊿⊿Ct)","2(-(⊿⊿Ct+SD))","2(-(⊿⊿Ct-SD))"]
["PH6WC",17.65,17.44,17.54,{"$f":"AVERAGE(B33:D33)","v":17.5433333333333},{"$f":"STDEV(B33:D33)","v":0.105039675043924},{"$f":"E33-E3","v":-2.39666666666667},0,{"$f":"POWER(2,-H33)","v":1},{"$f":"POWER(2,-(H33+F33))","v":0.929779372729265},{"$f":"POWER(2,-(H33-F33))","v":1.07552396765333}]
["PH4CV",20.48,20.26,20.38,{"$f":"AVERAGE(B34:D34)","v":20.3733333333333},{"$f":"STDEV(B34:D34)","v":0.110151410945721},{"$f":"E34-E4","v":-0.126666666666665},{"$f":"G34-G33","v":2.27},{"$f":"POWER(2,-H34)","v":0.20732988645361},{"$f":"POWER(2,-(H34+F34))","v":0.192089236824203},{"$f":"POWER(2,-(H34-F34))","v":0.223779752200311}]
["zma-miR396c_L-1","Ct1","Ct2","Ct3","Average Ct","SD","⊿Ct","⊿⊿Ct","2(-⊿⊿Ct)","2(-(⊿⊿Ct+SD))","2(-(⊿⊿Ct-SD))"]
["PH6WC",17.56,17.65,17.62,{"$f":"AVERAGE(B36:D36)","v":17.61},{"$f":"STDEV(B36:D36)","v":0.0458257569495586},{"$f":"E36-E3","v":-2.33},0,{"$f":"POWER(2,-H36)","v":1},{"$f":"POWER(2,-(H36+F36))","v":0.968735182198546},{"$f":"POWER(2,-(H36-F36))","v":1.03227385396543}]
["PH4CV",19.58,19.63,19.83,{"$f":"AVERAGE(B37:D37)","v":19.68},{"$f":"STDEV(B37:D37)","v":0.132287565553229},{"$f":"E37-E4","v":-0.820000000000004},{"$f":"G37-G36","v":1.50999999999999},{"$f":"POWER(2,-H37)","v":0.351111218934501},{"$f":"POWER(2,-(H37+F37))","v":0.320348121205693},{"$f":"POWER(2,-(H37-F37))","v":0.384828503434597}]
["zma-miR408b","Ct1","Ct2","Ct3","Average Ct","SD","⊿Ct","⊿⊿Ct","2(-⊿⊿Ct)","2(-(⊿⊿Ct+SD))","2(-(⊿⊿Ct-SD))"]
["PH6WC",16.09,16.14,16.11,{"$f":"AVERAGE(B39:D39)","v":16.1133333333333},{"$f":"STDEV(B39:D39)","v":0.0251661147842362},{"$f":"E39-E3","v":-3.82666666666666},0,{"$f":"POWER(2,-H39)","v":1},{"$f":"POWER(2,-(H39+F39))","v":0.982707441136163},{"$f":"POWER(2,-(H39-F39))","v":1.01759685348861}]
["PH4CV",17.75,17.76,17.81,{"$f":"AVERAGE(B40:D40)","v":17.7733333333333},{"$f":"STDEV(B40:D40)","v":0.0321455025366421},{"$f":"E40-E4","v":-2.72666666666666},{"$f":"G40-G39","v":1.1},{"$f":"POWER(2,-H40)","v":0.466516495768403},{"$f":"POWER(2,-(H40+F40))","v":0.456236728345239},{"$f":"POWER(2,-(H40-F40))","v":0.477027883338981}]
["zma-miR444a_1ss12TC,b_1ss12TC","Ct1","Ct2","Ct3","Average Ct","SD","⊿Ct","⊿⊿Ct","2(-⊿⊿Ct)","2(-(⊿⊿Ct+SD))","2(-(⊿⊿Ct-SD))"]
["PH6WC",21.33,20.88,20.48,{"$f":"AVERAGE(B42:D42)","v":20.8966666666667},{"$f":"STDEV(B42:D42)","v":0.425245027405768},{"$f":"E42-E3","v":0.956666666666667},0,{"$f":"POWER(2,-H42)","v":1},{"$f":"POWER(2,-(H42+F42))","v":0.744712238851936},{"$f":"POWER(2,-(H42-F42))","v":1.34280054473339}]
["PH4CV",23.39,23.01,23.1,{"$f":"AVERAGE(B43:D43)","v":23.1666666666667},{"$f":"STDEV(B43:D43)","v":0.198578280114753},{"$f":"E43-E4","v":2.66666666666667},{"$f":"G43-G42","v":1.71},{"$f":"POWER(2,-H43)","v":0.305660069423017},{"$f":"POWER(2,-(H43+F43))","v":0.26635489872219},{"$f":"POWER(2,-(H43-F43))","v":0.350765382907899}]
["zma-miR827_R-1-3p","Ct1","Ct2","Ct3","Average Ct","SD","⊿Ct","⊿⊿Ct","2(-⊿⊿Ct)","2(-(⊿⊿Ct+SD))","2(-(⊿⊿Ct-SD))"]
["PH6WC",21.94,21.96,21.96,{"$f":"AVERAGE(B45:D45)","v":21.9533333333333},{"$f":"STDEV(B45:D45)","v":0.0115470053837923},{"$f":"E45-E3","v":2.01333333333334},0,{"$f":"POWER(2,-H45)","v":1},{"$f":"POWER(2,-(H45+F45))","v":0.992028170691792},{"$f":"POWER(2,-(H45-F45))","v":1.00803589005204}]
["PH4CV",20.95,20.96,20.96,{"$f":"AVERAGE(B46:D46)","v":20.9566666666667},{"$f":"STDEV(B46:D46)","v":0.00577350269189716},{"$f":"E46-E4","v":0.456666666666667},{"$f":"G46-G45","v":-1.55666666666667},{"$f":"POWER(2,-H46)","v":2.94173372837191},{"$f":"POWER(2,-(H46+F46))","v":2.929984766764},{"$f":"POWER(2,-(H46-F46))","v":2.95352980220388}]
["PC-5p-1983_455","Ct1","Ct2","Ct3","Average Ct","SD","⊿Ct","⊿⊿Ct","2(-⊿⊿Ct)","2(-(⊿⊿Ct+SD))","2(-(⊿⊿Ct-SD))"]
["PH6WC",20.07,20.02,20.09,{"$f":"AVERAGE(B48:D48)","v":20.06},{"$f":"STDEV(B48:D48)","v":0.0360555127546401},{"$f":"E48-E3","v":0.120000000000005},0,{"$f":"POWER(2,-H48)","v":1},{"$f":"POWER(2,-(H48+F48))","v":0.975317932025427},{"$f":"POWER(2,-(H48-F48))","v":1.02530668940262}]
["PH4CV",21.86,21.84,21.82,{"$f":"AVERAGE(B49:D49)","v":21.84},{"$f":"STDEV(B49:D49)","v":0.0199999999999996},{"$f":"E49-E4","v":1.34},{"$f":"G49-G48","v":1.22},{"$f":"POWER(2,-H49)","v":0.429282718218877},{"$f":"POWER(2,-(H49+F49))","v":0.423372656181264},{"$f":"POWER(2,-(H49-F49))","v":0.435275281648062}]
["PC-5p-6152_162","Ct1","Ct2","Ct3","Average Ct","SD","⊿Ct","⊿⊿Ct","2(-⊿⊿Ct)","2(-(⊿⊿Ct+SD))","2(-(⊿⊿Ct-SD))"]
["PH6WC",20.67,20.71,20.68,{"$f":"AVERAGE(B51:D51)","v":20.6866666666667},{"$f":"STDEV(B51:D51)","v":0.0208166599946612},{"$f":"E51-E3","v":0.74666666666667},0,{"$f":"POWER(2,-H51)","v":1},{"$f":"POWER(2,-(H51+F51))","v":0.985674590092177},{"$f":"POWER(2,-(H51-F51))","v":1.01453360982602}]
["PH4CV",21.31,21.28,21.31,{"$f":"AVERAGE(B52:D52)","v":21.3},{"$f":"STDEV(B52:D52)","v":0.0173205080756874},{"$f":"E52-E4","v":0.800000000000001},{"$f":"G52-G51","v":0.053333333333331},{"$f":"POWER(2,-H52)","v":0.963707118391553},{"$f":"POWER(2,-(H52+F52))","v":0.952206352388608},{"$f":"POWER(2,-(H52-F52))","v":0.975346790859807}]
["PC-5p-9399_103","Ct1","Ct2","Ct3","Average Ct","SD","⊿Ct","⊿⊿Ct","2(-⊿⊿Ct)","2(-(⊿⊿Ct+SD))","2(-(⊿⊿Ct-SD))"]
["PH6WC",22.36,22.32,22.33,{"$f":"AVERAGE(B54:D54)","v":22.3366666666667},{"$f":"STDEV(B54:D54)","v":0.0208166599946612},{"$f":"E54-E3","v":2.39666666666666},0,{"$f":"POWER(2,-H54)","v":1},{"$f":"POWER(2,-(H54+F54))","v":0.985674590092177},{"$f":"POWER(2,-(H54-F54))","v":1.01453360982602}]
["PH4CV",24.13,24.16,24.15,{"$f":"AVERAGE(B55:D55)","v":24.1466666666667},{"$f":"STDEV(B55:D55)","v":0.0152752523165199},{"$f":"E55-E4","v":3.6466666666667},{"$f":"G55-G54","v":1.25000000000004},{"$f":"POWER(2,-H55)","v":0.420448207626847},{"$f":"POWER(2,-(H55+F55))","v":0.416019987177414},{"$f":"POWER(2,-(H55-F55))","v":0.424923563158612}]