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[null,"Supplementary 1: Mutations, MICs and Genotypic Data of Drug Resistant Strains \n"]
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[null,2519,"Mafric","Greater Accra","R","S",">1.00","<0.06","S315T","(-102G/A)",null,null,null,"L5",{"$nulls":6},"WA1"]
[null,2603,"Mafric","Greater Accra","R","R",">1.00",2,{"$nulls":5},"L5",{"$nulls":6},"WA1"]
[null,2660,"Mafric","Northern","R","S",1,"<0.06",{"$nulls":5},"L5",{"$nulls":6},"WA1"]
[null,2661,"Mafric","Greater Accra","R","S",">1.00","<0.06",{"$nulls":5},"L5",{"$nulls":6},"WA1"]
[null,2667,"Mafric","Northern","R","S",0.5,0.25,{"$nulls":5},"L5",{"$nulls":6},"WA1"]
[null,3064,"Mafric","Greater Accra","R","S",0.5,"<0.06",{"$nulls":5},"L5",{"$nulls":6},"WA1"]
[null,3082,"Mafric","Greater Accra","R","R",">1.00",">2.00",{"$nulls":5},"L5",{"$nulls":6},"WA1"]
[null,3110,"Mafric","Greater Accra","R","R",">1.00",1,{"$nulls":5},"L5",{"$nulls":6},"WA1"]
[null,3132,"Mafric","Greater Accra","R","S",0.5,0.25,{"$nulls":5},"L5",{"$nulls":6},"WA1"]
[null,"2428B","Mafric","Greater Accra","R","R",">1.00",0.5,{"$nulls":5},"L5",{"$nulls":6},"WA1"]
[null,1861,"Mafric","Greater Accra","R","S",0.5,"<0.06",{"$nulls":5},"L6",{"$nulls":6},"WA2"]
[null,1916,"Mafric","Greater Accra","R","R",1,1,{"$nulls":5},"L6",{"$nulls":6},"WA2"]
[null,1358,"Mafric","Northern","R","R",">1.00",">2.00",{"$nulls":5},"L6",{"$nulls":6},"WA2"]
[null,1401,"Mafric","Greater Accra","R","S",">1.00",0.25,"S315T","(-8T/C)","V117I",null,null,"L6",{"$nulls":6},"WA2"]
[null,3145,"Mafric","Greater Accra","R","S",">1.00","<0.06",{"$nulls":5},"L6",{"$nulls":6},"WA2"]
[null,2137,"Mafric","Greater Accra","R","S",">1.00","<0.06","S315T","(-8T/C)","V117I",null,null,"L6",{"$nulls":6},"WA2"]
[null,2656,"M.bovis","Northern","R","S",">1.00","<0.06",{"$nulls":5},"Animal",{"$nulls":6},"M. bovis"]
[null,2785,"M.bovis","Greater Accra","R","R",1,">2.00",{"$nulls":5},"Animal",{"$nulls":6},"M. bovis"]
[null,1898,"Mtbss","Greater Accra","S","S","<0.03","<0.06",null,"(-102G/A)",null,null,null,"L4",{"$nulls":6},"Ghana"]
[null,3286,"Mtbss","Greater Accra","S","S","<0.03","<0.06",null,"(-47G/C)",null,null,null,"L4",{"$nulls":6},"Cameroon"]
[]
[]
[null,"Legend:   Spoligotyping MIC data of all MTBC strains resistant to at least one drug are shown. However, mutations are shown for only those isolates with hypothesized compensatory mutations. Isolates with specific mutations are coloured to show that hypothesized spoligotype specific compensatory mutations are not phylogenetic markers (Olive green: Ghana spoligotype with katG S315T and G204D, Bright green : Cameroon spoligotype with katG S315T, inhA -8T/C and ndh V117I , Pink: Cameroon spoligotype with rpoB S450L and rpoC G322R, Light Yellow: Cameroon spoligotype with katG S315T and inhA G204D, Light Orange: Ghana spoligotype with katG S315T, rpoB S315T and rpoC V483G, Dark Blue: LAM spoligotype with katG S315T and inhA G204D, Bright Yellow: Uganda 1 spoligotype with katG S315T and inhA G204D, Purple: MAF Lineage 6 with katG S315T, inhA -8T/C and ndh V117I, Dark Orange: Ghana spoligotype with katG S315T and inhA -8T/C or -102G/A, Grey: Ghana spoligotype with katG S315T and inhA -47G/C, Sea Blue: MAF L5 with katG S315T and inhA -102G/A, Bright Green: Ghana spoligotype with with inhA -102G/A but susceptible to INH, Bright blue: Cameroon spoligotype with inhA -47G/C but susceptible to INH ).\n"]