Drug pairs with common pharmacological targets that improve of at least 50% the overall side effect for one of the 2 drugs Drug1 : DB00002 Cetuximab Drug2 : DB08916 Afatinib Pharmacological target (-,-) : BE0000767 Epidermal growth factor receptor Non-common off-target(s) (drug2) : BE0000511 Receptor tyrosine-protein kinase erbB-2 (-1) BE0004772 Receptor tyrosine-protein kinase erbB-4 (-1) --------------------------------------------------- Drug1 : DB00004 Denileukin diftitox Drug2 : DB00041 Aldesleukin Pharmacological target (+,+) : BE0000651 Interleukin-2 receptor subunit beta Non-common off-target(s) (drug2) : BE0000658 Interleukin-2 receptor subunit alpha (1) BE0002102 Cytokine receptor common subunit gamma (1) --------------------------------------------------- Drug1 : DB00050 Cetrorelix Drug2 : DB01406 Danazol Pharmacological target (-,-) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00065 Infliximab Drug2 : DB01041 Thalidomide Pharmacological target (-,-) : BE0000704 Tumor necrosis factor Non-common off-target(s) (drug2) : BE0000748 Fibroblast growth factor receptor 2 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0004755 Protein cereblon (-1) BE0001086 Nuclear factor NF-kappa-B p105 subunit (-1) --------------------------------------------------- Drug1 : DB00065 Infliximab Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000704 Tumor necrosis factor Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00106 Abarelix Drug2 : DB01406 Danazol Pharmacological target (-,-) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB00159 Icosapent Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB00244 Mesalazine Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB00586 Diclofenac Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB00795 Sulfasalazine Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB00812 Phenylbutazone Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB00939 Meclofenamic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB01014 Balsalazide Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB08814 Triflusal Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) BE0001086 Nuclear factor NF-kappa-B p105 subunit (-1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB00316 Acetaminophen Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB00482 Celecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) Non-common off-target(s) (drug2) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB00533 Rofecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB00580 Valdecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB00788 Naproxen Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB00812 Phenylbutazone Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) Non-common off-target(s) (drug2) : BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB00870 Suprofen Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB00936 Salicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) Non-common off-target(s) (drug2) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB00939 Meclofenamic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) Non-common off-target(s) (drug2) : BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB00945 Acetylsalicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) Non-common off-target(s) (drug2) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB00966 Telmisartan Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) Non-common off-target(s) (drug2) : BE0000062 Type-1 angiotensin II receptor (-1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB00991 Oxaprozin Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB01132 Pioglitazone Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB01393 Bezafibrate Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Pharmacological target (+,+) : BE0001007 Peroxisome proliferator-activated receptor delta Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) Non-common off-target(s) (drug2) : BE0000071 Peroxisome proliferator-activated receptor alpha (1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB08915 Aleglitazar Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) Non-common off-target(s) (drug2) : BE0000071 Peroxisome proliferator-activated receptor alpha (1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00191 Phentermine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00193 Tramadol Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00321 Amitriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00540 Nortriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00574 Fenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00579 Mazindol Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00656 Trazodone Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00852 Pseudoephedrine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB01149 Nefazodone Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB01242 Clomipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000814 Glutathione S-transferase P (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB01454 3,4-Methylenedioxymethamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00179 Masoprocol Drug2 : DB00244 Mesalazine Pharmacological target (-,-) : BE0000248 Arachidonate 5-lipoxygenase Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00179 Masoprocol Drug2 : DB00795 Sulfasalazine Pharmacological target (-,-) : BE0000248 Arachidonate 5-lipoxygenase Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00179 Masoprocol Drug2 : DB00939 Meclofenamic acid Pharmacological target (-,-) : BE0000248 Arachidonate 5-lipoxygenase Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) --------------------------------------------------- Drug1 : DB00179 Masoprocol Drug2 : DB01014 Balsalazide Pharmacological target (-,-) : BE0000248 Arachidonate 5-lipoxygenase Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB00206 Reserpine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB00245 Benzatropine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB00386 Alseroxylon Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB00745 Modafinil Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB01089 Deserpidine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB01255 Lisdexamfetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB01463 Fencamfamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB04844 Tetrabenazine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB06706 Isometheptene Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00411 Carbachol Pharmacological target (+,+) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00228 Enflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0004857 Glycine receptor (alpha-1/beta) (1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00231 Temazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00241 Butalbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00273 Topiramate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00292 Etomidate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00306 Talbutal Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00312 Pentobarbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00371 Meprobamate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00402 Eszopiclone Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00463 Metharbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00659 Acamprosate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0004852 Glutamate (NMDA) receptor (-1) BE0001192 Metabotropic glutamate receptor 5 (-1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00753 Isoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00794 Primidone Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00818 Propofol Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB01028 Methoxyflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB01189 Desflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB00489 Sotalol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB00598 Labetalol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB00866 Alprenolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB01118 Amiodarone Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00228 Enflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0004857 Glycine receptor (alpha-1/beta) (1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00231 Temazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00241 Butalbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00273 Topiramate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00292 Etomidate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00306 Talbutal Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00312 Pentobarbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00371 Meprobamate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00402 Eszopiclone Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00463 Metharbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00659 Acamprosate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0004852 Glutamate (NMDA) receptor (-1) BE0001192 Metabotropic glutamate receptor 5 (-1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00753 Isoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00794 Primidone Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00818 Propofol Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB01028 Methoxyflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB01189 Desflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00193 Tramadol Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00215 Citalopram Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00234 Reboxetine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00245 Benzatropine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00321 Amitriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00344 Protriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00458 Imipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00472 Fluoxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00540 Nortriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00745 Modafinil Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00752 Tranylcypromine Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00780 Phenelzine Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000253 4-aminobutyrate aminotransferase, mitochondrial (-1) BE0000667 Alanine aminotransferase 1 (-1) BE0002166 Alanine aminotransferase 2 (-1) BE0002173 Glutamic acid decarboxylase (-1) BE0001002 Membrane primary amine oxidase (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00830 Phenmetrazine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00934 Maprotiline Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00937 Diethylpropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB01171 Moclobemide Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB01247 Isocarboxazid Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB01255 Lisdexamfetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB01367 Rasagiline Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000246 Apoptosis regulator Bcl-2 (1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB01463 Fencamfamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB01576 Dextroamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB00281 Lidocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00215 Citalopram Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00234 Reboxetine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00472 Fluoxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00504 Levallorphan Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00802 Alfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00830 Phenmetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00852 Pseudoephedrine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00913 Anileridine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00937 Diethylpropion Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB01104 Sertraline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00195 Betaxolol Drug2 : DB01118 Amiodarone Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB00197 Troglitazone Drug2 : DB00244 Mesalazine Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000240 Plasminogen activator inhibitor 1 (-1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (-1) BE0001204 Equilibrative nucleoside transporter 1 (-1) BE0002088 Estrogen-related receptor gamma (-1) BE0003722 Steroid hormone receptor ERR1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00197 Troglitazone Drug2 : DB00795 Sulfasalazine Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000240 Plasminogen activator inhibitor 1 (-1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (-1) BE0001204 Equilibrative nucleoside transporter 1 (-1) BE0002088 Estrogen-related receptor gamma (-1) BE0003722 Steroid hormone receptor ERR1 (-1) Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00197 Troglitazone Drug2 : DB01014 Balsalazide Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000240 Plasminogen activator inhibitor 1 (-1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (-1) BE0001204 Equilibrative nucleoside transporter 1 (-1) BE0002088 Estrogen-related receptor gamma (-1) BE0003722 Steroid hormone receptor ERR1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00197 Troglitazone Drug2 : DB01393 Bezafibrate Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000240 Plasminogen activator inhibitor 1 (-1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (-1) BE0001204 Equilibrative nucleoside transporter 1 (-1) BE0002088 Estrogen-related receptor gamma (-1) BE0003722 Steroid hormone receptor ERR1 (-1) Non-common off-target(s) (drug2) : BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000071 Peroxisome proliferator-activated receptor alpha (1) --------------------------------------------------- Drug1 : DB00201 Caffeine Drug2 : DB01223 Aminophylline Pharmacological target (-,-) : BE0000013 Adenosine receptor A1 Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000924 Adenosine receptor A2a (-1) BE0004922 Cyclic nucleotide phosphodiesterase (-1) Non-common off-target(s) (drug2) : BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0000354 Adenosine receptor A3 (-1) --------------------------------------------------- Drug1 : DB00201 Caffeine Drug2 : DB01303 Oxtriphylline Pharmacological target (-,-) : BE0000013 Adenosine receptor A1 Pharmacological target (-,-) : BE0000924 Adenosine receptor A2a Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0004922 Cyclic nucleotide phosphodiesterase (-1) Non-common off-target(s) (drug2) : BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB00202 Succinylcholine Drug2 : DB01233 Metoclopramide Pharmacological target (+,+) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (1) BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00203 Sildenafil Drug2 : DB00277 Theophylline Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0003556 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (-1) BE0003557 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (-1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0000241 Adenosine receptor A2b (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB00203 Sildenafil Drug2 : DB00806 Pentoxifylline Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0003556 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (-1) BE0003557 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (-1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0001096 5'-nucleotidase (-1) --------------------------------------------------- Drug1 : DB00203 Sildenafil Drug2 : DB00975 Dipyridamole Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0003556 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (-1) BE0003557 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (-1) Non-common off-target(s) (drug2) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002214 Adenosine deaminase (-1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) --------------------------------------------------- Drug1 : DB00204 Dofetilide Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000090 Potassium voltage-gated channel subfamily H member 2 Non-common off-target(s) (drug1) : BE0000210 Potassium channel subfamily K member 2 (-1) BE0001131 ATP-sensitive inward rectifier potassium channel 12 (-1) Non-common off-target(s) (drug2) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00204 Dofetilide Drug2 : DB01218 Halofantrine Pharmacological target (-,-) : BE0000090 Potassium voltage-gated channel subfamily H member 2 Non-common off-target(s) (drug1) : BE0000210 Potassium channel subfamily K member 2 (-1) BE0001131 ATP-sensitive inward rectifier potassium channel 12 (-1) --------------------------------------------------- Drug1 : DB00205 Pyrimethamine Drug2 : DB00642 Pemetrexed Pharmacological target (-,-) : BE0000330 Dihydrofolate reductase Non-common off-target(s) (drug2) : BE0001240 Bifunctional purine biosynthesis protein PURH (-1) BE0000324 Thymidylate synthase (-1) BE0000882 Trifunctional purine biosynthetic protein adenosine-3 (-1) --------------------------------------------------- Drug1 : DB00206 Reserpine Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00206 Reserpine Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00206 Reserpine Drug2 : DB01454 3,4-Methylenedioxymethamphetamine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00206 Reserpine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00206 Reserpine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB00449 Dipivefrin Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB00865 Benzphetamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00214 Torasemide Drug2 : DB00887 Bumetanide Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000281 Solute carrier family 12 member 2 (-1) BE0000047 Solute carrier family 12 member 5 (-1) BE0000601 Solute carrier family 12 member 4 (-1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00214 Torasemide Drug2 : DB01325 Quinethazone Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000419 Solute carrier family 12 member 3 (-1) BE0000281 Solute carrier family 12 member 2 (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB00321 Amitriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB00540 Nortriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB00574 Fenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB00579 Mazindol Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB00656 Trazodone Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB00852 Pseudoephedrine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB01149 Nefazodone Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB01242 Clomipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000814 Glutathione S-transferase P (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB01454 3,4-Methylenedioxymethamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00217 Bethanidine Drug2 : DB00222 Glimepiride Pharmacological target (-,-) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 Non-common off-target(s) (drug1) : BE0004872 Beta adrenergic receptor (-1) BE0004864 Alpha-2 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000207 ATP-binding cassette sub-family C member 8 (1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) --------------------------------------------------- Drug1 : DB00217 Bethanidine Drug2 : DB08838 Agmatine Pharmacological target (-,-) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 Non-common off-target(s) (drug1) : BE0004872 Beta adrenergic receptor (-1) BE0004864 Alpha-2 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000342 Alpha-2C adrenergic receptor (1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0004661 Acetylcholine receptor subunit alpha (-1) BE0003580 Nischarin (1) BE0004768 Acid-sensing ion channel 3 (1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00332 Ipratropium bromide Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00340 Metixene Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00383 Oxyphencyclimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00387 Procyclidine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00505 Tridihexethyl Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00508 Triflupromazine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00517 Anisotropine Methylbromide Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00572 Atropine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00725 Homatropine Methylbromide Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00785 Cryptenamine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00222 Glimepiride Drug2 : DB00414 Acetohexamide Pharmacological target (-,-) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 Non-common off-target(s) (drug1) : BE0000207 ATP-binding cassette sub-family C member 8 (1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) --------------------------------------------------- Drug1 : DB00222 Glimepiride Drug2 : DB00839 Tolazamide Pharmacological target (-,-) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 Non-common off-target(s) (drug1) : BE0000207 ATP-binding cassette sub-family C member 8 (1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) --------------------------------------------------- Drug1 : DB00228 Enflurane Drug2 : DB00237 Butabarbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0004857 Glycine receptor (alpha-1/beta) (1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00228 Enflurane Drug2 : DB00349 Clobazam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0004857 Glycine receptor (alpha-1/beta) (1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00228 Enflurane Drug2 : DB00404 Alprazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0004857 Glycine receptor (alpha-1/beta) (1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00228 Enflurane Drug2 : DB00475 Chlordiazepoxide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0004857 Glycine receptor (alpha-1/beta) (1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00228 Enflurane Drug2 : DB00628 Clorazepate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0004857 Glycine receptor (alpha-1/beta) (1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00228 Enflurane Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0004857 Glycine receptor (alpha-1/beta) (1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00228 Enflurane Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0004857 Glycine receptor (alpha-1/beta) (1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00228 Enflurane Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0004857 Glycine receptor (alpha-1/beta) (1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00228 Enflurane Drug2 : DB08883 Perampanel Pharmacological target (-,-) : BE0000640 Glutamate receptor 1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0004857 Glycine receptor (alpha-1/beta) (1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00230 Pregabalin Drug2 : DB01244 Bepridil Pharmacological target (-,-) : BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A Non-common off-target(s) (drug2) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 (-1) BE0003565 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (-1) BE0003323 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (-1) BE0000672 Potassium voltage-gated channel subfamily KQT member 1 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00237 Butabarbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00241 Butalbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00292 Etomidate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00306 Talbutal Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00312 Pentobarbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00349 Clobazam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00371 Meprobamate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00404 Alprazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00418 Secobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00463 Metharbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00475 Chlordiazepoxide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00592 Piperazine Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00599 Thiopental Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0002194 Fatty-acid amide hydrolase 1 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00628 Clorazepate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00794 Primidone Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00818 Propofol Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00849 Methylphenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01351 Amobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01352 Aprobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01353 Butethal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01354 Heptabarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01355 Hexobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01440 Gamma Hydroxybutyric Acid Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01483 Barbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00232 Methyclothiazide Drug2 : DB00887 Bumetanide Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) Non-common off-target(s) (drug2) : BE0000281 Solute carrier family 12 member 2 (-1) BE0000047 Solute carrier family 12 member 5 (-1) BE0000601 Solute carrier family 12 member 4 (-1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB00321 Amitriptyline Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB00540 Nortriptyline Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB00579 Mazindol Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB00852 Pseudoephedrine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB01149 Nefazodone Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB01454 3,4-Methylenedioxymethamphetamine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB01576 Dextroamphetamine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00235 Milrinone Drug2 : DB00277 Theophylline Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0002366 Histone deacetylase 2 (1) BE0000241 Adenosine receptor A2b (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB00235 Milrinone Drug2 : DB01223 Aminophylline Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug2) : BE0000013 Adenosine receptor A1 (-1) BE0002366 Histone deacetylase 2 (1) BE0000354 Adenosine receptor A3 (-1) --------------------------------------------------- Drug1 : DB00235 Milrinone Drug2 : DB01303 Oxtriphylline Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug2) : BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0002366 Histone deacetylase 2 (1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB00273 Topiramate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB00292 Etomidate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB00371 Meprobamate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB00402 Eszopiclone Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB00659 Acamprosate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0004852 Glutamate (NMDA) receptor (-1) BE0001192 Metabotropic glutamate receptor 5 (-1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB00753 Isoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB00818 Propofol Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB01028 Methoxyflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB01189 Desflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB00292 Etomidate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB00349 Clobazam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB00404 Alprazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB00475 Chlordiazepoxide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB00546 Adinazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB00628 Clorazepate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB00683 Midazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB00690 Flurazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00242 Cladribine Drug2 : DB00441 Gemcitabine Pharmacological target (-,-) : BE0000325 Ribonucleoside-diphosphate reductase large subunit Non-common off-target(s) (drug1) : BE0002450 Ribonucleoside-diphosphate reductase subunit M2 (-1) BE0003613 Ribonucleoside-diphosphate reductase subunit M2 B (-1) BE0000546 DNA polymerase alpha catalytic subunit (-1) BE0003614 DNA polymerase epsilon catalytic subunit A (-1) BE0003615 DNA polymerase epsilon subunit 2 (-1) BE0003617 DNA polymerase epsilon subunit 3 (-1) BE0003616 DNA polymerase epsilon subunit 4 (-1) BE0000250 Purine nucleoside phosphorylase (1) Non-common off-target(s) (drug2) : BE0000324 Thymidylate synthase (-1) BE0000637 UMP-CMP kinase (-1) --------------------------------------------------- Drug1 : DB00242 Cladribine Drug2 : DB00631 Clofarabine Pharmacological target (-,-) : BE0000325 Ribonucleoside-diphosphate reductase large subunit Pharmacological target (-,-) : BE0000546 DNA polymerase alpha catalytic subunit Non-common off-target(s) (drug1) : BE0002450 Ribonucleoside-diphosphate reductase subunit M2 (-1) BE0003613 Ribonucleoside-diphosphate reductase subunit M2 B (-1) BE0003614 DNA polymerase epsilon catalytic subunit A (-1) BE0003615 DNA polymerase epsilon subunit 2 (-1) BE0003617 DNA polymerase epsilon subunit 3 (-1) BE0003616 DNA polymerase epsilon subunit 4 (-1) BE0000250 Purine nucleoside phosphorylase (1) --------------------------------------------------- Drug1 : DB00242 Cladribine Drug2 : DB01005 Hydroxyurea Pharmacological target (-,-) : BE0000325 Ribonucleoside-diphosphate reductase large subunit Non-common off-target(s) (drug1) : BE0002450 Ribonucleoside-diphosphate reductase subunit M2 (-1) BE0003613 Ribonucleoside-diphosphate reductase subunit M2 B (-1) BE0000546 DNA polymerase alpha catalytic subunit (-1) BE0003614 DNA polymerase epsilon catalytic subunit A (-1) BE0003615 DNA polymerase epsilon subunit 2 (-1) BE0003617 DNA polymerase epsilon subunit 3 (-1) BE0003616 DNA polymerase epsilon subunit 4 (-1) BE0000250 Purine nucleoside phosphorylase (1) --------------------------------------------------- Drug1 : DB00242 Cladribine Drug2 : DB01073 Fludarabine Pharmacological target (-,-) : BE0000325 Ribonucleoside-diphosphate reductase large subunit Pharmacological target (-,-) : BE0000546 DNA polymerase alpha catalytic subunit Non-common off-target(s) (drug1) : BE0002450 Ribonucleoside-diphosphate reductase subunit M2 (-1) BE0003613 Ribonucleoside-diphosphate reductase subunit M2 B (-1) BE0003614 DNA polymerase epsilon catalytic subunit A (-1) BE0003615 DNA polymerase epsilon subunit 2 (-1) BE0003617 DNA polymerase epsilon subunit 3 (-1) BE0003616 DNA polymerase epsilon subunit 4 (-1) BE0000250 Purine nucleoside phosphorylase (1) Non-common off-target(s) (drug2) : BE0002804 Deoxycytidine kinase (1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB00412 Rosiglitazone Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) Non-common off-target(s) (drug2) : BE0000996 Long-chain-fatty-acid--CoA ligase 4 (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB00482 Celecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) Non-common off-target(s) (drug2) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB00533 Rofecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB00580 Valdecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB00744 Zileuton Pharmacological target (-,-) : BE0000248 Arachidonate 5-lipoxygenase Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB00966 Telmisartan Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) Non-common off-target(s) (drug2) : BE0000062 Type-1 angiotensin II receptor (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB01132 Pioglitazone Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB08915 Aleglitazar Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) Non-common off-target(s) (drug2) : BE0000071 Peroxisome proliferator-activated receptor alpha (1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00332 Ipratropium bromide Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00340 Metixene Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00383 Oxyphencyclimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00387 Procyclidine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00505 Tridihexethyl Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00508 Triflupromazine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00517 Anisotropine Methylbromide Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00572 Atropine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00579 Mazindol Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00721 Procaine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00725 Homatropine Methylbromide Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00785 Cryptenamine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00852 Pseudoephedrine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB01576 Dextroamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB00434 Cyproheptadine Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB00490 Buspirone Pharmacological target (+,+) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB00924 Cyclobenzaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB08810 Cinitapride Pharmacological target (+,+) : BE0000291 5-hydroxytryptamine receptor 1A Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB00273 Topiramate Pharmacological target (-,-) : BE0000141 Sodium channel protein type 1 subunit alpha Non-common off-target(s) (drug1) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB00281 Lidocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Pharmacological target (-,-) : BE0000141 Sodium channel protein type 1 subunit alpha Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00255 Diethylstilbestrol Drug2 : DB00269 Chlorotrianisene Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0002088 Estrogen-related receptor gamma (1) BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00255 Diethylstilbestrol Drug2 : DB00286 Conjugated Estrogens Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0002088 Estrogen-related receptor gamma (1) BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00255 Diethylstilbestrol Drug2 : DB00294 Etonogestrel Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0002088 Estrogen-related receptor gamma (1) BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00255 Diethylstilbestrol Drug2 : DB00304 Desogestrel Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0002088 Estrogen-related receptor gamma (1) BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00255 Diethylstilbestrol Drug2 : DB00603 Medroxyprogesterone Acetate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0002088 Estrogen-related receptor gamma (1) BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00255 Diethylstilbestrol Drug2 : DB00655 Estrone Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0002088 Estrogen-related receptor gamma (1) BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00255 Diethylstilbestrol Drug2 : DB00823 Ethynodiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0002088 Estrogen-related receptor gamma (1) BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00255 Diethylstilbestrol Drug2 : DB00890 Dienestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0002088 Estrogen-related receptor gamma (1) BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00255 Diethylstilbestrol Drug2 : DB00957 Norgestimate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0002088 Estrogen-related receptor gamma (1) BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00255 Diethylstilbestrol Drug2 : DB00977 Ethinyl Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0002088 Estrogen-related receptor gamma (1) BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00255 Diethylstilbestrol Drug2 : DB01357 Mestranol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0002088 Estrogen-related receptor gamma (1) BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00255 Diethylstilbestrol Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0002088 Estrogen-related receptor gamma (1) BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00261 Anagrelide Drug2 : DB00277 Theophylline Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0002366 Histone deacetylase 2 (1) BE0000241 Adenosine receptor A2b (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB00261 Anagrelide Drug2 : DB01223 Aminophylline Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug2) : BE0000013 Adenosine receptor A1 (-1) BE0002366 Histone deacetylase 2 (1) BE0000354 Adenosine receptor A3 (-1) --------------------------------------------------- Drug1 : DB00261 Anagrelide Drug2 : DB01303 Oxtriphylline Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug2) : BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0002366 Histone deacetylase 2 (1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB00264 Metoprolol Drug2 : DB01118 Amiodarone Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB00396 Progesterone Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB01196 Estramustine Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00270 Isradipine Drug2 : DB00996 Gabapentin Pharmacological target (-,-) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 Pharmacological target (-,-) : BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) Non-common off-target(s) (drug2) : BE0000013 Adenosine receptor A1 (1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) --------------------------------------------------- Drug1 : DB00270 Isradipine Drug2 : DB01244 Bepridil Pharmacological target (-,-) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H Pharmacological target (-,-) : BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) Non-common off-target(s) (drug2) : BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 (-1) BE0003565 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (-1) BE0003323 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (-1) BE0000672 Potassium voltage-gated channel subfamily KQT member 1 (-1) --------------------------------------------------- Drug1 : DB00270 Isradipine Drug2 : DB01388 Mibefradil Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00272 Betazole Drug2 : DB00667 Histamine Phosphate Pharmacological target (+,+) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB00292 Etomidate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB00311 Ethoxzolamide Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Pharmacological target (-,-) : BE0000535 Carbonic anhydrase 4 Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0003629 Carbonic anhydrase 7 (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB00349 Clobazam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB00402 Eszopiclone Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB00404 Alprazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB00425 Zolpidem Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB00475 Chlordiazepoxide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB00628 Clorazepate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB00703 Methazolamide Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Pharmacological target (-,-) : BE0000535 Carbonic anhydrase 4 Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0003629 Carbonic anhydrase 7 (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB00880 Chlorothiazide Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Pharmacological target (-,-) : BE0000535 Carbonic anhydrase 4 Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000419 Solute carrier family 12 member 3 (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB01031 Ethinamate Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB01121 Phenacemide Pharmacological target (-,-) : BE0000141 Sodium channel protein type 1 subunit alpha Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB01144 Diclofenamide Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Pharmacological target (-,-) : BE0000535 Carbonic anhydrase 4 Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0003629 Carbonic anhydrase 7 (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB01438 Phenazopyridine Pharmacological target (-,-) : BE0000141 Sodium channel protein type 1 subunit alpha Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB04930 Permethrin Pharmacological target (-,-) : BE0000141 Sodium channel protein type 1 subunit alpha Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) --------------------------------------------------- Drug1 : DB00276 Amsacrine Drug2 : DB01179 Podofilox Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000143 Tubulin beta chain (-1) BE0001391 Tubulin alpha-4A chain (-1) --------------------------------------------------- Drug1 : DB00276 Amsacrine Drug2 : DB04967 Lucanthone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000971 DNA topoisomerase 1 (-1) BE0002414 DNA-(apurinic or apyrimidinic site) lyase (-1) --------------------------------------------------- Drug1 : DB00277 Theophylline Drug2 : DB00820 Tadalafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0000241 Adenosine receptor A2b (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) Non-common off-target(s) (drug2) : BE0003558 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (-1) --------------------------------------------------- Drug1 : DB00277 Theophylline Drug2 : DB00824 Enprofylline Pharmacological target (-,-) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Pharmacological target (-,-) : BE0000241 Adenosine receptor A2b Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) --------------------------------------------------- Drug1 : DB00277 Theophylline Drug2 : DB00862 Vardenafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0000241 Adenosine receptor A2b (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB00277 Theophylline Drug2 : DB00975 Dipyridamole Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0000241 Adenosine receptor A2b (-1) Non-common off-target(s) (drug2) : BE0002214 Adenosine deaminase (-1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) --------------------------------------------------- Drug1 : DB00277 Theophylline Drug2 : DB01113 Papaverine Pharmacological target (-,-) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Non-common off-target(s) (drug1) : BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0000241 Adenosine receptor A2b (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) Non-common off-target(s) (drug2) : BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) --------------------------------------------------- Drug1 : DB00277 Theophylline Drug2 : DB01166 Cilostazol Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0002366 Histone deacetylase 2 (1) BE0000241 Adenosine receptor A2b (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB00277 Theophylline Drug2 : DB01223 Aminophylline Pharmacological target (+,+) : BE0002366 Histone deacetylase 2 Pharmacological target (-,-) : BE0000013 Adenosine receptor A1 Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000924 Adenosine receptor A2a (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0000241 Adenosine receptor A2b (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) Non-common off-target(s) (drug2) : BE0000354 Adenosine receptor A3 (-1) --------------------------------------------------- Drug1 : DB00277 Theophylline Drug2 : DB04880 Enoximone Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0002366 Histone deacetylase 2 (1) BE0000241 Adenosine receptor A2b (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB00277 Theophylline Drug2 : DB06237 Avanafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0000241 Adenosine receptor A2b (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB00277 Theophylline Drug2 : DB06267 Udenafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0000241 Adenosine receptor A2b (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB00277 Theophylline Drug2 : DB06751 Drotaverine Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0000241 Adenosine receptor A2b (-1) Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB00281 Lidocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB00296 Ropivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB00297 Bupivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB00379 Mexiletine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB00532 Mephenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB00564 Carbamazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB00645 Dyclonine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB00680 Moricizine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB00740 Riluzole Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB00750 Prilocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB00754 Ethotoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB00776 Oxcarbazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB00807 Proparacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB00892 Oxybuprocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB00908 Quinidine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Pharmacological target (-,-) : BE0001143 Sodium channel protein type 9 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB00961 Mepivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB01002 Levobupivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB01086 Benzocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB01161 Chloroprocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00282 Pamidronate Drug2 : DB00720 Clodronate Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0000776 Farnesyl pyrophosphate synthase (-1) Non-common off-target(s) (drug2) : BE0000599 ADP/ATP translocase 1 (-1) BE0000709 ADP/ATP translocase 2 (-1) BE0000624 ADP/ATP translocase 3 (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00434 Cyproheptadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00568 Cinnarizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00284 Acarbose Drug2 : DB04878 Voglibose Pharmacological target (-,-) : BE0000837 Maltase-glucoamylase, intestinal Non-common off-target(s) (drug1) : BE0002639 Pancreatic alpha-amylase (-1) BE0000876 Lysosomal alpha-glucosidase (-1) BE0001176 Sucrase-isomaltase, intestinal (-1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB00574 Fenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB00656 Trazodone Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB00396 Progesterone Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB01196 Estramustine Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00287 Travoprost Drug2 : DB00905 Bimatoprost Pharmacological target (+,+) : BE0000610 Prostaglandin F2-alpha receptor Non-common off-target(s) (drug2) : BE0000064 Prostaglandin E2 receptor EP1 subtype (1) BE0002375 Prostaglandin E2 receptor EP3 subtype (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00306 Talbutal Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00312 Pentobarbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00349 Clobazam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00371 Meprobamate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00404 Alprazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00425 Zolpidem Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00463 Metharbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00475 Chlordiazepoxide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00628 Clorazepate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00697 Tizanidine Pharmacological target (+,+) : BE0000572 Alpha-2B adrenergic receptor Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0003580 Nischarin (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00753 Isoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00794 Primidone Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB01028 Methoxyflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00293 Raltitrexed Drug2 : DB00642 Pemetrexed Pharmacological target (-,-) : BE0000324 Thymidylate synthase Non-common off-target(s) (drug1) : BE0000700 Folylpolyglutamate synthase, mitochondrial (-1) Non-common off-target(s) (drug2) : BE0001240 Bifunctional purine biosynthesis protein PURH (-1) BE0000330 Dihydrofolate reductase (-1) BE0000882 Trifunctional purine biosynthetic protein adenosine-3 (-1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB01196 Estramustine Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB01395 Drospirenone Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) Non-common off-target(s) (drug2) : BE0000132 Androgen receptor (-1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB00504 Levallorphan Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB00802 Alfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB00913 Anileridine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00296 Ropivacaine Drug2 : DB00721 Procaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00297 Bupivacaine Drug2 : DB00721 Procaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB00450 Droperidol Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB00679 Thioridazine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB00692 Phentolamine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB00699 Nicergoline Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB00797 Tolazoline Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB01196 Estramustine Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB01395 Drospirenone Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) Non-common off-target(s) (drug2) : BE0000132 Androgen receptor (-1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB00349 Clobazam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB00404 Alprazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB00475 Chlordiazepoxide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB00546 Adinazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB00628 Clorazepate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB00683 Midazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB00690 Flurazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00308 Ibutilide Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000090 Potassium voltage-gated channel subfamily H member 2 Non-common off-target(s) (drug1) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00308 Ibutilide Drug2 : DB01218 Halofantrine Pharmacological target (-,-) : BE0000090 Potassium voltage-gated channel subfamily H member 2 Non-common off-target(s) (drug1) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00310 Chlorthalidone Drug2 : DB00887 Bumetanide Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000281 Solute carrier family 12 member 2 (-1) BE0000047 Solute carrier family 12 member 5 (-1) BE0000601 Solute carrier family 12 member 4 (-1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00310 Chlorthalidone Drug2 : DB01325 Quinethazone Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000419 Solute carrier family 12 member 3 (-1) BE0000281 Solute carrier family 12 member 2 (-1) --------------------------------------------------- Drug1 : DB00311 Ethoxzolamide Drug2 : DB01325 Quinethazone Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Non-common off-target(s) (drug1) : BE0000535 Carbonic anhydrase 4 (-1) BE0003629 Carbonic anhydrase 7 (-1) Non-common off-target(s) (drug2) : BE0000502 Solute carrier family 12 member 1 (-1) BE0000419 Solute carrier family 12 member 3 (-1) BE0000281 Solute carrier family 12 member 2 (-1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB00349 Clobazam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB00404 Alprazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB00475 Chlordiazepoxide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB00546 Adinazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB00628 Clorazepate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB00683 Midazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB00690 Flurazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00315 Zolmitriptan Drug2 : DB00490 Buspirone Pharmacological target (+,+) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00315 Zolmitriptan Drug2 : DB08810 Cinitapride Pharmacological target (+,+) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB00586 Diclofenac Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB08814 Triflusal Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug1) : BE0000262 Prostaglandin G/H synthase 2 (-1) Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) BE0001086 Nuclear factor NF-kappa-B p105 subunit (-1) --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00317 Gefitinib Drug2 : DB08916 Afatinib Pharmacological target (-,-) : BE0000767 Epidermal growth factor receptor Non-common off-target(s) (drug2) : BE0000511 Receptor tyrosine-protein kinase erbB-2 (-1) BE0004772 Receptor tyrosine-protein kinase erbB-4 (-1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB00504 Levallorphan Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB00802 Alfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB00913 Anileridine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB00408 Loxapine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB00472 Fluoxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB00830 Phenmetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB00924 Cyclobenzaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB00937 Diethylpropion Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB01104 Sertraline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB00504 Levallorphan Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB00802 Alfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB00913 Anileridine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00328 Indomethacin Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000962 Lactoylglutathione lyase (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0003560 Prostaglandin reductase 2 (-1) BE0000071 Peroxisome proliferator-activated receptor alpha (1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00354 Buclizine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00483 Gallamine Triethiodide Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00508 Triflupromazine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00670 Pirenzepine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00728 Rocuronium Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00729 Diphemanil Methylsulfate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB01625 Isopropamide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB00392 Ethopropazine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000770 Mu-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB00504 Levallorphan Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000420 Delta-type opioid receptor (1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB00802 Alfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000420 Delta-type opioid receptor (1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB00913 Anileridine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000420 Delta-type opioid receptor (1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB00915 Amantadine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000770 Mu-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB01116 Trimethaphan Pharmacological target (-,-) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000770 Mu-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000420 Delta-type opioid receptor (1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB01221 Ketamine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000770 Mu-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000632 Kappa-type opioid receptor (1) BE0000384 Substance-P receptor (-1) BE0004957 5-hydroxytryptamine receptor 2 (-1) BE0004958 5-hydroxytryptamine receptor 1 (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000420 Delta-type opioid receptor (1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000420 Delta-type opioid receptor (1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000420 Delta-type opioid receptor (1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB03575 Phencyclidine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000770 Mu-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000420 Delta-type opioid receptor (1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB00489 Sotalol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB00598 Labetalol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB00866 Alprenolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB01118 Amiodarone Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB00340 Metixene Drug2 : DB00354 Buclizine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00340 Metixene Drug2 : DB00670 Pirenzepine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00340 Metixene Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00340 Metixene Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00340 Metixene Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00340 Metixene Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00340 Metixene Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00434 Cyproheptadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00568 Cinnarizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00568 Cinnarizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00343 Diltiazem Drug2 : DB01054 Nitrendipine Pharmacological target (-,-) : BE0000679 Voltage-dependent calcium channel gamma-1 subunit Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB00574 Fenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB00656 Trazodone Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB00852 Pseudoephedrine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB01149 Nefazodone Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB01576 Dextroamphetamine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB00450 Droperidol Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB00679 Thioridazine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB00692 Phentolamine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB00699 Nicergoline Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB00797 Tolazoline Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00347 Trimethadione Drug2 : DB00568 Cinnarizine Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00347 Trimethadione Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00347 Trimethadione Drug2 : DB01388 Mibefradil Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00347 Trimethadione Drug2 : DB04841 Flunarizine Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB00371 Meprobamate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB00402 Eszopiclone Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB00463 Metharbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB00659 Acamprosate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0004852 Glutamate (NMDA) receptor (-1) BE0001192 Metabotropic glutamate receptor 5 (-1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB00753 Isoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB00794 Primidone Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB00818 Propofol Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB01028 Methoxyflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB01189 Desflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00351 Megestrol acetate Drug2 : DB00396 Progesterone Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (1) Non-common off-target(s) (drug2) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000123 Estrogen receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00351 Megestrol acetate Drug2 : DB01395 Drospirenone Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (1) Non-common off-target(s) (drug2) : BE0000132 Androgen receptor (-1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00351 Megestrol acetate Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (1) Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00353 Methylergometrine Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00353 Methylergometrine Drug2 : DB00508 Triflupromazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) --------------------------------------------------- Drug1 : DB00353 Methylergometrine Drug2 : DB00679 Thioridazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00353 Methylergometrine Drug2 : DB00875 Flupentixol Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00353 Methylergometrine Drug2 : DB01038 Carphenazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00353 Methylergometrine Drug2 : DB01239 Chlorprothixene Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00353 Methylergometrine Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00353 Methylergometrine Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00353 Methylergometrine Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00353 Methylergometrine Drug2 : DB01624 Zuclopenthixol Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00383 Oxyphencyclimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00387 Procyclidine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00505 Tridihexethyl Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00508 Triflupromazine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00517 Anisotropine Methylbromide Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00568 Cinnarizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00572 Atropine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00725 Homatropine Methylbromide Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00785 Cryptenamine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00361 Vinorelbine Drug2 : DB01179 Podofilox Pharmacological target (-,-) : BE0000143 Tubulin beta chain Non-common off-target(s) (drug2) : BE0000742 DNA topoisomerase 2-alpha (-1) BE0001391 Tubulin alpha-4A chain (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00568 Cinnarizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00449 Dipivefrin Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00484 Brimonidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (+,+) : BE0000572 Alpha-2B adrenergic receptor Pharmacological target (+,+) : BE0000342 Alpha-2C adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00610 Metaraminol Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00629 Guanabenz Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00633 Dexmedetomidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00816 Orciprenaline Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00865 Benzphetamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00867 Ritodrine Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00871 Terbutaline Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00938 Salmeterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00983 Formoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB01018 Guanfacine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB01064 Isoprenaline Pharmacological target (+,+) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Pharmacological target (+,+) : BE0001012 Beta-3 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB01253 Ergonovine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB01274 Arformoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB01363 Ephedra Pharmacological target (+,+) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (+,+) : BE0000572 Alpha-2B adrenergic receptor Pharmacological target (+,+) : BE0000342 Alpha-2C adrenergic receptor Pharmacological target (+,+) : BE0001012 Beta-3 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB01366 Procaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB01408 Bambuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB04948 Lofexidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB05039 Indacaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB06706 Isometheptene Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB06707 Levonordefrin Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB08893 Mirabegron Pharmacological target (+,+) : BE0001012 Beta-3 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00377 Palonosetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00692 Phentolamine Pharmacological target (-,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00757 Dolasetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00889 Granisetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00904 Ondansetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00924 Cyclobenzaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00925 Phenoxybenzamine Pharmacological target (-,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00969 Alosetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB01199 Tubocurarine Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB01608 Propericiazine Pharmacological target (-,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00404 Alprazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00475 Chlordiazepoxide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00546 Adinazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00628 Clorazepate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00683 Midazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00690 Flurazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB01118 Amiodarone Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB00374 Treprostinil Drug2 : DB01088 Iloprost Pharmacological target (+,+) : BE0000475 Prostacyclin receptor Non-common off-target(s) (drug1) : BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000110 P2Y purinoceptor 12 (1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (1) BE0000064 Prostaglandin E2 receptor EP1 subtype (1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (1) --------------------------------------------------- Drug1 : DB00377 Palonosetron Drug2 : DB00721 Procaine Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00378 Dydrogesterone Drug2 : DB00396 Progesterone Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug2) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000123 Estrogen receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00378 Dydrogesterone Drug2 : DB01395 Drospirenone Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug2) : BE0000132 Androgen receptor (-1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00378 Dydrogesterone Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00380 Dexrazoxane Drug2 : DB01179 Podofilox Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0000143 Tubulin beta chain (-1) BE0001391 Tubulin alpha-4A chain (-1) --------------------------------------------------- Drug1 : DB00380 Dexrazoxane Drug2 : DB04967 Lucanthone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0000971 DNA topoisomerase 1 (-1) BE0002414 DNA-(apurinic or apyrimidinic site) lyase (-1) --------------------------------------------------- Drug1 : DB00381 Amlodipine Drug2 : DB00568 Cinnarizine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 (-1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0003563 Voltage-dependent calcium channel subunit alpha-2/delta-3 (-1) BE0003564 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00381 Amlodipine Drug2 : DB01388 Mibefradil Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0003563 Voltage-dependent calcium channel subunit alpha-2/delta-3 (-1) BE0003564 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d (-1) Non-common off-target(s) (drug2) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00382 Tacrine Drug2 : DB00805 Minaprine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00483 Gallamine Triethiodide Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00508 Triflupromazine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00670 Pirenzepine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00728 Rocuronium Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00729 Diphemanil Methylsulfate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB01625 Isopropamide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00385 Valrubicin Drug2 : DB01179 Podofilox Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0000143 Tubulin beta chain (-1) BE0001391 Tubulin alpha-4A chain (-1) --------------------------------------------------- Drug1 : DB00385 Valrubicin Drug2 : DB04967 Lucanthone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0000971 DNA topoisomerase 1 (-1) BE0002414 DNA-(apurinic or apyrimidinic site) lyase (-1) --------------------------------------------------- Drug1 : DB00386 Alseroxylon Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00386 Alseroxylon Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00386 Alseroxylon Drug2 : DB01454 3,4-Methylenedioxymethamphetamine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00386 Alseroxylon Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00386 Alseroxylon Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB00483 Gallamine Triethiodide Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB00508 Triflupromazine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB00670 Pirenzepine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB00728 Rocuronium Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB00729 Diphemanil Methylsulfate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB00508 Triflupromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB00679 Thioridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB00831 Trifluoperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB00875 Flupentixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB01038 Carphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB01624 Zuclopenthixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB00514 Dextromethorphan Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000850 Neuronal acetylcholine receptor subunit beta-2 (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) BE0003584 Neuronal acetylcholine receptor subunit beta-4 (-1) BE0000770 Mu-type opioid receptor (1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) BE0000290 HCG20471, isoform CRA_c (1) BE0004904 NADPH oxidase (-1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB00721 Procaine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB00898 Ethanol Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000433 Glycine receptor subunit alpha-1 (1) BE0000745 Glycine receptor subunit alpha-2 (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB00949 Felbamate Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB01043 Memantine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000756 D(2) dopamine receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB01520 Tenocyclidine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000454 Glutamate receptor ionotropic, NMDA 2C (-1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00393 Nimodipine Drug2 : DB00622 Nicardipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Non-common off-target(s) (drug1) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0003721 Aryl hydrocarbon receptor (1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000668 Mineralocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0003565 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (-1) BE0003323 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (-1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB00481 Raloxifene Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB00655 Estrone Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB00700 Eplerenone Pharmacological target (-,-) : BE0000668 Mineralocorticoid receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB00783 Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB00890 Dienestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB00977 Ethinyl Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB01357 Mestranol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000668 Mineralocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB04573 Estriol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB04574 Estropipate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB06713 Norelgestromin Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000123 Estrogen receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB00484 Brimonidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB01577 Methamphetamine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00398 Sorafenib Drug2 : DB06589 Pazopanib Pharmacological target (-,-) : BE0000205 Platelet-derived growth factor receptor beta Pharmacological target (-,-) : BE0000369 Vascular endothelial growth factor receptor 2 Pharmacological target (-,-) : BE0000453 Mast/stem cell growth factor receptor Kit Pharmacological target (-,-) : BE0000029 Vascular endothelial growth factor receptor 1 Non-common off-target(s) (drug1) : BE0002131 Fibroblast growth factor receptor 1 (-1) BE0000634 Serine/threonine-protein kinase B-raf (-1) BE0000036 RAF proto-oncogene serine/threonine-protein kinase (-1) BE0000023 Vascular endothelial growth factor receptor 3 (-1) BE0000147 Receptor-type tyrosine-protein kinase FLT3 (-1) BE0002411 Proto-oncogene tyrosine-protein kinase receptor Ret (-1) Non-common off-target(s) (drug2) : BE0002133 Fibroblast growth factor receptor 3 (-1) BE0000852 Platelet-derived growth factor receptor alpha (-1) BE0000689 Fibroblast growth factor 1 (-1) BE0001341 Tyrosine-protein kinase ITK/TSK (-1) BE0004714 SH2B adapter protein 3 (-1) --------------------------------------------------- Drug1 : DB00398 Sorafenib Drug2 : DB06626 Axitinib Pharmacological target (-,-) : BE0000023 Vascular endothelial growth factor receptor 3 Pharmacological target (-,-) : BE0000369 Vascular endothelial growth factor receptor 2 Pharmacological target (-,-) : BE0000029 Vascular endothelial growth factor receptor 1 Non-common off-target(s) (drug1) : BE0002131 Fibroblast growth factor receptor 1 (-1) BE0000205 Platelet-derived growth factor receptor beta (-1) BE0000634 Serine/threonine-protein kinase B-raf (-1) BE0000036 RAF proto-oncogene serine/threonine-protein kinase (-1) BE0000147 Receptor-type tyrosine-protein kinase FLT3 (-1) BE0000453 Mast/stem cell growth factor receptor Kit (-1) BE0002411 Proto-oncogene tyrosine-protein kinase receptor Ret (-1) --------------------------------------------------- Drug1 : DB00398 Sorafenib Drug2 : DB08875 Cabozantinib Pharmacological target (-,-) : BE0000369 Vascular endothelial growth factor receptor 2 Pharmacological target (-,-) : BE0002411 Proto-oncogene tyrosine-protein kinase receptor Ret Non-common off-target(s) (drug1) : BE0002131 Fibroblast growth factor receptor 1 (-1) BE0000205 Platelet-derived growth factor receptor beta (-1) BE0000634 Serine/threonine-protein kinase B-raf (-1) BE0000036 RAF proto-oncogene serine/threonine-protein kinase (-1) BE0000023 Vascular endothelial growth factor receptor 3 (-1) BE0000147 Receptor-type tyrosine-protein kinase FLT3 (-1) BE0000453 Mast/stem cell growth factor receptor Kit (-1) BE0000029 Vascular endothelial growth factor receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000915 Hepatocyte growth factor receptor (-1) --------------------------------------------------- Drug1 : DB00398 Sorafenib Drug2 : DB08881 Vemurafenib Pharmacological target (-,-) : BE0000634 Serine/threonine-protein kinase B-raf Non-common off-target(s) (drug1) : BE0002131 Fibroblast growth factor receptor 1 (-1) BE0000205 Platelet-derived growth factor receptor beta (-1) BE0000036 RAF proto-oncogene serine/threonine-protein kinase (-1) BE0000023 Vascular endothelial growth factor receptor 3 (-1) BE0000369 Vascular endothelial growth factor receptor 2 (-1) BE0000147 Receptor-type tyrosine-protein kinase FLT3 (-1) BE0000453 Mast/stem cell growth factor receptor Kit (-1) BE0002411 Proto-oncogene tyrosine-protein kinase receptor Ret (-1) BE0000029 Vascular endothelial growth factor receptor 1 (-1) --------------------------------------------------- Drug1 : DB00398 Sorafenib Drug2 : DB08912 Dabrafenib Pharmacological target (-,-) : BE0000634 Serine/threonine-protein kinase B-raf Pharmacological target (-,-) : BE0000036 RAF proto-oncogene serine/threonine-protein kinase Non-common off-target(s) (drug1) : BE0002131 Fibroblast growth factor receptor 1 (-1) BE0000205 Platelet-derived growth factor receptor beta (-1) BE0000023 Vascular endothelial growth factor receptor 3 (-1) BE0000369 Vascular endothelial growth factor receptor 2 (-1) BE0000147 Receptor-type tyrosine-protein kinase FLT3 (-1) BE0000453 Mast/stem cell growth factor receptor Kit (-1) BE0002411 Proto-oncogene tyrosine-protein kinase receptor Ret (-1) BE0000029 Vascular endothelial growth factor receptor 1 (-1) Non-common off-target(s) (drug2) : BE0004757 Serine/threonine-protein kinase SIK1 (-1) BE0004758 Serine/threonine-protein kinase Nek11 (-1) BE0004759 LIM domain kinase 1 (-1) --------------------------------------------------- Drug1 : DB00399 Zoledronate Drug2 : DB01077 Etidronic acid Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0000776 Farnesyl pyrophosphate synthase (-1) BE0003570 Geranylgeranyl pyrophosphate synthase (-1) Non-common off-target(s) (drug2) : BE0003567 Receptor-type tyrosine-protein phosphatase S (-1) BE0003569 V-type proton ATPase catalytic subunit A (-1) --------------------------------------------------- Drug1 : DB00399 Zoledronate Drug2 : DB01133 Tiludronate Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0000776 Farnesyl pyrophosphate synthase (-1) BE0003570 Geranylgeranyl pyrophosphate synthase (-1) Non-common off-target(s) (drug2) : BE0003569 V-type proton ATPase catalytic subunit A (-1) BE0000623 Tyrosine-protein phosphatase non-receptor type 1 (-1) --------------------------------------------------- Drug1 : DB00401 Nisoldipine Drug2 : DB00568 Cinnarizine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00401 Nisoldipine Drug2 : DB01388 Mibefradil Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) Non-common off-target(s) (drug2) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB00404 Alprazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB00475 Chlordiazepoxide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB00753 Isoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB01028 Methoxyflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB01178 Chlormezanone Pharmacological target (+,+) : BE0000736 Translocator protein Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000736 Translocator protein Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB00463 Metharbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB00659 Acamprosate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0004852 Glutamate (NMDA) receptor (-1) BE0001192 Metabotropic glutamate receptor 5 (-1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB00753 Isoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB00794 Primidone Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB00818 Propofol Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB01028 Methoxyflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB01189 Desflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00434 Cyproheptadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00568 Cinnarizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00407 Ardeparin Drug2 : DB06779 Dalteparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000775 Heparin cofactor 2 (1) Non-common off-target(s) (drug2) : BE0000967 Tissue factor pathway inhibitor (-1) BE0000163 Vascular endothelial growth factor A (-1) BE0001159 P-selectin (-1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB00831 Trifluoperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB01100 Pimozide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000581 D(3) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB00508 Triflupromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB00679 Thioridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB00831 Trifluoperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB00875 Flupentixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB01038 Carphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB01624 Zuclopenthixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB01019 Bethanechol Pharmacological target (+,+) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB01233 Metoclopramide Pharmacological target (+,+) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB01245 Decamethonium Pharmacological target (+,+) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00412 Rosiglitazone Drug2 : DB00795 Sulfasalazine Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000996 Long-chain-fatty-acid--CoA ligase 4 (-1) Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00412 Rosiglitazone Drug2 : DB01014 Balsalazide Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000996 Long-chain-fatty-acid--CoA ligase 4 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00412 Rosiglitazone Drug2 : DB01393 Bezafibrate Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000996 Long-chain-fatty-acid--CoA ligase 4 (-1) Non-common off-target(s) (drug2) : BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000071 Peroxisome proliferator-activated receptor alpha (1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB00915 Amantadine Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00414 Acetohexamide Drug2 : DB08838 Agmatine Pharmacological target (-,-) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 Non-common off-target(s) (drug2) : BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000342 Alpha-2C adrenergic receptor (1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0004661 Acetylcholine receptor subunit alpha (-1) BE0003580 Nischarin (1) BE0004768 Acid-sensing ion channel 3 (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB00546 Adinazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB00683 Midazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB00690 Flurazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00420 Promazine Drug2 : DB01100 Pimozide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000581 D(3) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00422 Methylphenidate Drug2 : DB00721 Procaine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00424 Hyoscyamine Drug2 : DB00508 Triflupromazine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00425 Zolpidem Drug2 : DB00753 Isoflurane Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00425 Zolpidem Drug2 : DB00898 Ethanol Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000745 Glycine receptor subunit alpha-2 (1) --------------------------------------------------- Drug1 : DB00425 Zolpidem Drug2 : DB01028 Methoxyflurane Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00425 Zolpidem Drug2 : DB01154 Thiamylal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) Non-common off-target(s) (drug2) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) --------------------------------------------------- Drug1 : DB00425 Zolpidem Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00425 Zolpidem Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00434 Cyproheptadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00568 Cinnarizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00429 Carboprost Tromethamine Drug2 : DB00905 Bimatoprost Pharmacological target (+,+) : BE0000064 Prostaglandin E2 receptor EP1 subtype Non-common off-target(s) (drug2) : BE0000610 Prostaglandin F2-alpha receptor (1) BE0002375 Prostaglandin E2 receptor EP3 subtype (1) --------------------------------------------------- Drug1 : DB00429 Carboprost Tromethamine Drug2 : DB00917 Dinoprostone Pharmacological target (+,+) : BE0000064 Prostaglandin E2 receptor EP1 subtype Non-common off-target(s) (drug2) : BE0000368 Prostaglandin E2 receptor EP2 subtype (1) BE0002375 Prostaglandin E2 receptor EP3 subtype (1) BE0003522 Prostaglandin E2 receptor EP4 subtype (1) --------------------------------------------------- Drug1 : DB00432 Trifluridine Drug2 : DB00642 Pemetrexed Pharmacological target (-,-) : BE0000324 Thymidylate synthase Non-common off-target(s) (drug2) : BE0001240 Bifunctional purine biosynthesis protein PURH (-1) BE0000330 Dihydrofolate reductase (-1) BE0000882 Trifunctional purine biosynthetic protein adenosine-3 (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB00508 Triflupromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB00679 Thioridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB00831 Trifluoperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB00875 Flupentixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01038 Carphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01100 Pimozide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000581 D(3) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01239 Chlorprothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01267 Paliperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01624 Zuclopenthixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00455 Loratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00557 Hydroxyzine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00637 Astemizole Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00719 Azatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00737 Meclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00748 Carbinoxamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00924 Cyclobenzaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB01149 Nefazodone Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00441 Gemcitabine Drug2 : DB01073 Fludarabine Pharmacological target (-,-) : BE0000325 Ribonucleoside-diphosphate reductase large subunit Non-common off-target(s) (drug1) : BE0000324 Thymidylate synthase (-1) BE0000637 UMP-CMP kinase (-1) Non-common off-target(s) (drug2) : BE0000546 DNA polymerase alpha catalytic subunit (-1) BE0002804 Deoxycytidine kinase (1) --------------------------------------------------- Drug1 : DB00444 Teniposide Drug2 : DB01179 Podofilox Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0000143 Tubulin beta chain (-1) BE0001391 Tubulin alpha-4A chain (-1) --------------------------------------------------- Drug1 : DB00444 Teniposide Drug2 : DB04967 Lucanthone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0000971 DNA topoisomerase 1 (-1) BE0002414 DNA-(apurinic or apyrimidinic site) lyase (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00610 Metaraminol Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00629 Guanabenz Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00633 Dexmedetomidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00723 Methoxamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00733 Pralidoxime Pharmacological target (+,+) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00816 Orciprenaline Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00867 Ritodrine Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00871 Terbutaline Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00938 Salmeterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00983 Formoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01001 Salbutamol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01018 Guanfacine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01253 Ergonovine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01274 Arformoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01288 Fenoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01291 Pirbuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01363 Ephedra Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01366 Procaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01407 Clenbuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0001094 Beta-nerve growth factor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01408 Bambuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01579 Phendimetrazine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB04948 Lofexidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB05039 Indacaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB06706 Isometheptene Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB06707 Levonordefrin Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00457 Prazosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00508 Triflupromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00590 Doxazosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00679 Thioridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB01038 Carphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB01100 Pimozide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000581 D(3) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB01162 Terazosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB01239 Chlorprothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00568 Cinnarizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00457 Prazosin Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00457 Prazosin Drug2 : DB00692 Phentolamine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00457 Prazosin Drug2 : DB00699 Nicergoline Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00457 Prazosin Drug2 : DB00797 Tolazoline Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) --------------------------------------------------- Drug1 : DB00457 Prazosin Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00459 Acitretin Drug2 : DB04942 Tamibarotene Pharmacological target (+,+) : BE0000206 Retinoic acid receptor beta Pharmacological target (+,+) : BE0000663 Retinoic acid receptor alpha Non-common off-target(s) (drug1) : BE0000301 Retinol-binding protein 1 (1) BE0000144 Retinoic acid receptor gamma (1) BE0000707 Retinoic acid receptor RXR-gamma (1) BE0000078 Retinoic acid receptor RXR-beta (1) BE0000412 Retinoic acid receptor RXR-alpha (1) --------------------------------------------------- Drug1 : DB00461 Nabumetone Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00462 Methylscopolamine bromide Drug2 : DB00508 Triflupromazine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB00475 Chlordiazepoxide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB00546 Adinazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB00628 Clorazepate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB00683 Midazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB00690 Flurazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00465 Ketorolac Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01205 Flumazenil Pharmacological target (-,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00469 Tenoxicam Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB00540 Nortriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB00574 Fenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB00579 Mazindol Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB00656 Trazodone Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB00852 Pseudoephedrine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB01149 Nefazodone Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB01242 Clomipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000814 Glutathione S-transferase P (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB01454 3,4-Methylenedioxymethamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00473 Hexylcaine Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00473 Hexylcaine Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01205 Flumazenil Pharmacological target (-,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB00659 Acamprosate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0004852 Glutamate (NMDA) receptor (-1) BE0001192 Metabotropic glutamate receptor 5 (-1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB00753 Isoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB00794 Primidone Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB00818 Propofol Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB01028 Methoxyflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB01189 Desflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00476 Duloxetine Drug2 : DB00574 Fenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) --------------------------------------------------- Drug1 : DB00476 Duloxetine Drug2 : DB00656 Trazodone Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00476 Duloxetine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00476 Duloxetine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00476 Duloxetine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00557 Hydroxyzine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00590 Doxazosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00623 Fluphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00637 Astemizole Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00692 Phentolamine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00699 Nicergoline Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00719 Azatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00737 Meclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00748 Carbinoxamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00831 Trifluoperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00835 Brompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00850 Perphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00924 Cyclobenzaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01038 Carphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01063 Acetophenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01162 Terazosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01184 Domperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01359 Penbutolol Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000797 5-hydroxytryptamine receptor 1B (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01616 Alverine Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00481 Raloxifene Drug2 : DB01196 Estramustine Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) --------------------------------------------------- Drug1 : DB00481 Raloxifene Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00586 Diclofenac Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00795 Sulfasalazine Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00812 Phenylbutazone Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00939 Meclofenamic acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB01014 Balsalazide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB00505 Tridihexethyl Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB00508 Triflupromazine Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB00517 Anisotropine Methylbromide Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB00572 Atropine Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB00725 Homatropine Methylbromide Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB00785 Cryptenamine Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB00805 Minaprine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00484 Brimonidine Drug2 : DB00629 Guanabenz Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00484 Brimonidine Drug2 : DB00633 Dexmedetomidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00484 Brimonidine Drug2 : DB01018 Guanfacine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00484 Brimonidine Drug2 : DB01363 Ephedra Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (+,+) : BE0000572 Alpha-2B adrenergic receptor Pharmacological target (+,+) : BE0000342 Alpha-2C adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00484 Brimonidine Drug2 : DB01577 Methamphetamine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (+,+) : BE0000572 Alpha-2B adrenergic receptor Pharmacological target (+,+) : BE0000342 Alpha-2C adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00484 Brimonidine Drug2 : DB04948 Lofexidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00484 Brimonidine Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (+,+) : BE0000572 Alpha-2B adrenergic receptor Pharmacological target (+,+) : BE0000342 Alpha-2C adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00484 Brimonidine Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000090 Potassium voltage-gated channel subfamily H member 2 Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB01218 Halofantrine Pharmacological target (-,-) : BE0000090 Potassium voltage-gated channel subfamily H member 2 Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB01297 Practolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB00508 Triflupromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB00656 Trazodone Pharmacological target (+,+) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB00669 Sumatriptan Pharmacological target (+,+) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB00679 Thioridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB00831 Trifluoperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB00875 Flupentixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB00952 Naratriptan Pharmacological target (+,+) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01038 Carphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01100 Pimozide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000581 D(3) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01239 Chlorprothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01624 Zuclopenthixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00491 Miglitol Drug2 : DB04878 Voglibose Pharmacological target (-,-) : BE0000837 Maltase-glucoamylase, intestinal Non-common off-target(s) (drug1) : BE0000876 Lysosomal alpha-glucosidase (-1) BE0004698 Neutral alpha-glucosidase AB (-1) BE0004699 Neutral alpha-glucosidase C (-1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB00504 Levallorphan Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0004899 Kappa-type opioid receptor 2b (1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB00802 Alfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0004899 Kappa-type opioid receptor 2b (1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB00913 Anileridine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0004899 Kappa-type opioid receptor 2b (1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0004899 Kappa-type opioid receptor 2b (1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0004899 Kappa-type opioid receptor 2b (1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0004899 Kappa-type opioid receptor 2b (1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0004899 Kappa-type opioid receptor 2b (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00499 Flutamide Drug2 : DB01395 Drospirenone Pharmacological target (-,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00500 Tolmetin Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00501 Cimetidine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00502 Haloperidol Drug2 : DB00831 Trifluoperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00502 Haloperidol Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB00647 Dextropropoxyphene Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB00836 Loperamide Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB00508 Triflupromazine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB00670 Pirenzepine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB00728 Rocuronium Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB00729 Diphemanil Methylsulfate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB01625 Isopropamide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB00517 Anisotropine Methylbromide Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB00623 Fluphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB00670 Pirenzepine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB00728 Rocuronium Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB00850 Perphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB00986 Glycopyrrolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB01038 Carphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB01063 Acetophenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB01184 Domperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB01608 Propericiazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB01618 Molindone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB01624 Zuclopenthixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB04842 Fluspirilene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB06288 Amisulpride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00514 Dextromethorphan Drug2 : DB00915 Amantadine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000850 Neuronal acetylcholine receptor subunit beta-2 (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) BE0003584 Neuronal acetylcholine receptor subunit beta-4 (-1) BE0000770 Mu-type opioid receptor (1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) BE0000290 HCG20471, isoform CRA_c (1) BE0004904 NADPH oxidase (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00514 Dextromethorphan Drug2 : DB03575 Phencyclidine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000850 Neuronal acetylcholine receptor subunit beta-2 (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) BE0003584 Neuronal acetylcholine receptor subunit beta-4 (-1) BE0000770 Mu-type opioid receptor (1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) BE0000290 HCG20471, isoform CRA_c (1) BE0004904 NADPH oxidase (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB00670 Pirenzepine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB00728 Rocuronium Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB00729 Diphemanil Methylsulfate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB01625 Isopropamide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00523 Alitretinoin Drug2 : DB04942 Tamibarotene Pharmacological target (+,+) : BE0000206 Retinoic acid receptor beta Pharmacological target (+,+) : BE0000663 Retinoic acid receptor alpha Non-common off-target(s) (drug1) : BE0000144 Retinoic acid receptor gamma (1) BE0000707 Retinoic acid receptor RXR-gamma (1) BE0000078 Retinoic acid receptor RXR-beta (1) BE0000412 Retinoic acid receptor RXR-alpha (1) --------------------------------------------------- Drug1 : DB00524 Metolazone Drug2 : DB00880 Chlorothiazide Pharmacological target (-,-) : BE0000419 Solute carrier family 12 member 3 Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) --------------------------------------------------- Drug1 : DB00524 Metolazone Drug2 : DB01325 Quinethazone Pharmacological target (-,-) : BE0000419 Solute carrier family 12 member 3 Non-common off-target(s) (drug2) : BE0000502 Solute carrier family 12 member 1 (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000281 Solute carrier family 12 member 2 (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB00721 Procaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00528 Lercanidipine Drug2 : DB01054 Nitrendipine Pharmacological target (-,-) : BE0000679 Voltage-dependent calcium channel gamma-1 subunit Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) --------------------------------------------------- Drug1 : DB00530 Erlotinib Drug2 : DB08916 Afatinib Pharmacological target (-,-) : BE0000767 Epidermal growth factor receptor Non-common off-target(s) (drug1) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) Non-common off-target(s) (drug2) : BE0000511 Receptor tyrosine-protein kinase erbB-2 (-1) BE0004772 Receptor tyrosine-protein kinase erbB-4 (-1) --------------------------------------------------- Drug1 : DB00532 Mephenytoin Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00532 Mephenytoin Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00532 Mephenytoin Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00586 Diclofenac Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00795 Sulfasalazine Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00812 Phenylbutazone Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00939 Meclofenamic acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB01014 Balsalazide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB00830 Phenmetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB00924 Cyclobenzaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB00937 Diethylpropion Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB01104 Sertraline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00545 Pyridostigmine Drug2 : DB00805 Minaprine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB00592 Piperazine Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB00599 Thiopental Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB00794 Primidone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB00818 Propofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB00849 Methylphenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01351 Amobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01352 Aprobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01353 Butethal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01354 Heptabarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01355 Hexobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01440 Gamma Hydroxybutyric Acid Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01483 Barbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00548 Azelaic Acid Drug2 : DB01126 Dutasteride Pharmacological target (-,-) : BE0000585 3-oxo-5-alpha-steroid 4-dehydrogenase 2 Non-common off-target(s) (drug1) : BE0000252 Tyrosinase (-1) BE0003610 3-oxo-5-beta-steroid 4-dehydrogenase (-1) Non-common off-target(s) (drug2) : BE0000539 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (-1) --------------------------------------------------- Drug1 : DB00552 Pentostatin Drug2 : DB00975 Dipyridamole Pharmacological target (-,-) : BE0002214 Adenosine deaminase Non-common off-target(s) (drug2) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) --------------------------------------------------- Drug1 : DB00554 Piroxicam Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00568 Cinnarizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00563 Methotrexate Drug2 : DB00642 Pemetrexed Pharmacological target (-,-) : BE0000330 Dihydrofolate reductase Non-common off-target(s) (drug2) : BE0001240 Bifunctional purine biosynthesis protein PURH (-1) BE0000324 Thymidylate synthase (-1) BE0000882 Trifunctional purine biosynthetic protein adenosine-3 (-1) --------------------------------------------------- Drug1 : DB00564 Carbamazepine Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00564 Carbamazepine Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00564 Carbamazepine Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00593 Ethosuximide Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00617 Paramethadione Pharmacological target (-,-) : BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00622 Nicardipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 (-1) BE0003565 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (-1) BE0003323 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00637 Astemizole Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00719 Azatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00737 Meclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00748 Carbinoxamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00751 Epinastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00777 Propiomazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00835 Brompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB05246 Methsuximide Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00569 Fondaparinux sodium Drug2 : DB06779 Dalteparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000216 Coagulation factor X (-1) Non-common off-target(s) (drug2) : BE0000967 Tissue factor pathway inhibitor (-1) BE0000163 Vascular endothelial growth factor A (-1) BE0001159 P-selectin (-1) --------------------------------------------------- Drug1 : DB00571 Propranolol Drug2 : DB01118 Amiodarone Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) BE0001012 Beta-3 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB00670 Pirenzepine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB00728 Rocuronium Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB00729 Diphemanil Methylsulfate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00573 Fenoprofen Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00574 Fenfluramine Drug2 : DB00715 Paroxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00574 Fenfluramine Drug2 : DB01104 Sertraline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00574 Fenfluramine Drug2 : DB01175 Escitalopram Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00574 Fenfluramine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00574 Fenfluramine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00574 Fenfluramine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00575 Clonidine Drug2 : DB00629 Guanabenz Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00575 Clonidine Drug2 : DB00633 Dexmedetomidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00575 Clonidine Drug2 : DB01018 Guanfacine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00575 Clonidine Drug2 : DB01363 Ephedra Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (+,+) : BE0000572 Alpha-2B adrenergic receptor Pharmacological target (+,+) : BE0000342 Alpha-2C adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00575 Clonidine Drug2 : DB01577 Methamphetamine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (+,+) : BE0000572 Alpha-2B adrenergic receptor Pharmacological target (+,+) : BE0000342 Alpha-2C adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00575 Clonidine Drug2 : DB04948 Lofexidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB00745 Modafinil Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB00934 Maprotiline Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB01255 Lisdexamfetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB01463 Fencamfamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB00586 Diclofenac Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB00795 Sulfasalazine Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB00812 Phenylbutazone Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB00939 Meclofenamic acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB01014 Balsalazide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00585 Nizatidine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB00788 Naproxen Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB00812 Phenylbutazone Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) Non-common off-target(s) (drug2) : BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB00870 Suprofen Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB00936 Salicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) Non-common off-target(s) (drug2) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB00945 Acetylsalicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) Non-common off-target(s) (drug2) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB00991 Oxaprozin Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0002083 Sodium channel protein type 4 subunit alpha Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0000353 Acid-sensing ion channel 1 (-1) Non-common off-target(s) (drug2) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00589 Lisuride Drug2 : DB00915 Amantadine Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00590 Doxazosin Drug2 : DB00692 Phentolamine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00590 Doxazosin Drug2 : DB00699 Nicergoline Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00590 Doxazosin Drug2 : DB00797 Tolazoline Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) --------------------------------------------------- Drug1 : DB00590 Doxazosin Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00592 Piperazine Drug2 : DB00683 Midazolam Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00592 Piperazine Drug2 : DB00690 Flurazepam Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00592 Piperazine Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00592 Piperazine Drug2 : DB00818 Propofol Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00592 Piperazine Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00592 Piperazine Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00592 Piperazine Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00592 Piperazine Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00592 Piperazine Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00592 Piperazine Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00592 Piperazine Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00592 Piperazine Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00592 Piperazine Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00592 Piperazine Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00592 Piperazine Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00593 Ethosuximide Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00593 Ethosuximide Drug2 : DB01388 Mibefradil Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00593 Ethosuximide Drug2 : DB04841 Flunarizine Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB01297 Practolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB00683 Midazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB00690 Flurazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00603 Medroxyprogesterone Acetate Drug2 : DB01196 Estramustine Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) --------------------------------------------------- Drug1 : DB00603 Medroxyprogesterone Acetate Drug2 : DB01395 Drospirenone Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) Non-common off-target(s) (drug2) : BE0000132 Androgen receptor (-1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00603 Medroxyprogesterone Acetate Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00605 Sulindac Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000747 Aldose reductase (-1) BE0001007 Peroxisome proliferator-activated receptor delta (-1) BE0003561 Prostaglandin D2 receptor 2 (-1) BE0001062 Mitogen-activated protein kinase 3 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB00668 Epinephrine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB00696 Ergotamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB00865 Benzphetamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB06694 Xylometazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00611 Butorphanol Drug2 : DB09049 Naloxegol Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00612 Bisoprolol Drug2 : DB01118 Amiodarone Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB00617 Paramethadione Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00617 Paramethadione Drug2 : DB01388 Mibefradil Pharmacological target (-,-) : BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) --------------------------------------------------- Drug1 : DB00617 Paramethadione Drug2 : DB04841 Flunarizine Pharmacological target (-,-) : BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) --------------------------------------------------- Drug1 : DB00621 Oxandrolone Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000123 Estrogen receptor (-1) --------------------------------------------------- Drug1 : DB00621 Oxandrolone Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00622 Nicardipine Drug2 : DB00661 Verapamil Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0003565 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (-1) BE0003323 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00622 Nicardipine Drug2 : DB01388 Mibefradil Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0003565 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (-1) BE0003323 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (-1) Non-common off-target(s) (drug2) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB00679 Thioridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB01239 Chlorprothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00624 Testosterone Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000123 Estrogen receptor (-1) --------------------------------------------------- Drug1 : DB00624 Testosterone Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB00659 Acamprosate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0004852 Glutamate (NMDA) receptor (-1) BE0001192 Metabotropic glutamate receptor 5 (-1) --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB00753 Isoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB00794 Primidone Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB00818 Propofol Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB01028 Methoxyflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB01189 Desflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB00668 Epinephrine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB00865 Benzphetamine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB01363 Ephedra Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB01577 Methamphetamine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB06694 Xylometazoline Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00630 Alendronate Drug2 : DB00720 Clodronate Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0000776 Farnesyl pyrophosphate synthase (-1) BE0000980 Tyrosine-protein phosphatase non-receptor type 4 (-1) BE0003567 Receptor-type tyrosine-protein phosphatase S (-1) BE0003568 Receptor-type tyrosine-protein phosphatase epsilon (-1) BE0003569 V-type proton ATPase catalytic subunit A (-1) Non-common off-target(s) (drug2) : BE0000599 ADP/ATP translocase 1 (-1) BE0000709 ADP/ATP translocase 2 (-1) BE0000624 ADP/ATP translocase 3 (-1) --------------------------------------------------- Drug1 : DB00633 Dexmedetomidine Drug2 : DB00668 Epinephrine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00633 Dexmedetomidine Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00633 Dexmedetomidine Drug2 : DB00865 Benzphetamine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00633 Dexmedetomidine Drug2 : DB01363 Ephedra Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00633 Dexmedetomidine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00633 Dexmedetomidine Drug2 : DB01577 Methamphetamine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00633 Dexmedetomidine Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00633 Dexmedetomidine Drug2 : DB06694 Xylometazoline Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00636 Clofibrate Drug2 : DB01393 Bezafibrate Pharmacological target (+,+) : BE0000071 Peroxisome proliferator-activated receptor alpha Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00640 Adenosine Drug2 : DB06213 Regadenoson Pharmacological target (+,+) : BE0000924 Adenosine receptor A2a Non-common off-target(s) (drug1) : BE0000013 Adenosine receptor A1 (1) BE0000241 Adenosine receptor A2b (1) BE0000354 Adenosine receptor A3 (1) --------------------------------------------------- Drug1 : DB00642 Pemetrexed Drug2 : DB00650 Leucovorin Pharmacological target (-,-) : BE0000324 Thymidylate synthase Non-common off-target(s) (drug1) : BE0001240 Bifunctional purine biosynthesis protein PURH (-1) BE0000330 Dihydrofolate reductase (-1) BE0000882 Trifunctional purine biosynthetic protein adenosine-3 (-1) --------------------------------------------------- Drug1 : DB00642 Pemetrexed Drug2 : DB01101 Capecitabine Pharmacological target (-,-) : BE0000324 Thymidylate synthase Non-common off-target(s) (drug1) : BE0001240 Bifunctional purine biosynthesis protein PURH (-1) BE0000330 Dihydrofolate reductase (-1) BE0000882 Trifunctional purine biosynthetic protein adenosine-3 (-1) --------------------------------------------------- Drug1 : DB00642 Pemetrexed Drug2 : DB01131 Proguanil Pharmacological target (-,-) : BE0000330 Dihydrofolate reductase Non-common off-target(s) (drug1) : BE0001240 Bifunctional purine biosynthesis protein PURH (-1) BE0000324 Thymidylate synthase (-1) BE0000882 Trifunctional purine biosynthetic protein adenosine-3 (-1) --------------------------------------------------- Drug1 : DB00642 Pemetrexed Drug2 : DB01157 Trimetrexate Pharmacological target (-,-) : BE0000330 Dihydrofolate reductase Non-common off-target(s) (drug1) : BE0001240 Bifunctional purine biosynthesis protein PURH (-1) BE0000324 Thymidylate synthase (-1) BE0000882 Trifunctional purine biosynthetic protein adenosine-3 (-1) --------------------------------------------------- Drug1 : DB00645 Dyclonine Drug2 : DB00721 Procaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB00802 Alfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB00913 Anileridine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00651 Dyphylline Drug2 : DB00824 Enprofylline Pharmacological target (-,-) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) Non-common off-target(s) (drug2) : BE0000241 Adenosine receptor A2b (-1) --------------------------------------------------- Drug1 : DB00651 Dyphylline Drug2 : DB01113 Papaverine Pharmacological target (-,-) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Non-common off-target(s) (drug1) : BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) Non-common off-target(s) (drug2) : BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) --------------------------------------------------- Drug1 : DB00651 Dyphylline Drug2 : DB01303 Oxtriphylline Pharmacological target (-,-) : BE0000013 Adenosine receptor A1 Pharmacological target (-,-) : BE0000924 Adenosine receptor A2a Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) Non-common off-target(s) (drug2) : BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) --------------------------------------------------- Drug1 : DB00651 Dyphylline Drug2 : DB06751 Drotaverine Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB09049 Naloxegol Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00654 Latanoprost Drug2 : DB00905 Bimatoprost Pharmacological target (+,+) : BE0000610 Prostaglandin F2-alpha receptor Non-common off-target(s) (drug2) : BE0000064 Prostaglandin E2 receptor EP1 subtype (1) BE0002375 Prostaglandin E2 receptor EP3 subtype (1) --------------------------------------------------- Drug1 : DB00655 Estrone Drug2 : DB01196 Estramustine Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) --------------------------------------------------- Drug1 : DB00655 Estrone Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB00715 Paroxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB00924 Cyclobenzaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB01104 Sertraline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00659 Acamprosate Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0004852 Glutamate (NMDA) receptor (-1) BE0001192 Metabotropic glutamate receptor 5 (-1) --------------------------------------------------- Drug1 : DB00659 Acamprosate Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0004852 Glutamate (NMDA) receptor (-1) BE0001192 Metabotropic glutamate receptor 5 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00659 Acamprosate Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0004852 Glutamate (NMDA) receptor (-1) BE0001192 Metabotropic glutamate receptor 5 (-1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00659 Acamprosate Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0004852 Glutamate (NMDA) receptor (-1) BE0001192 Metabotropic glutamate receptor 5 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00665 Nilutamide Drug2 : DB01395 Drospirenone Pharmacological target (-,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB00816 Orciprenaline Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB00865 Benzphetamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB00867 Ritodrine Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB00871 Terbutaline Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB00938 Salmeterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB00983 Formoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB01018 Guanfacine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB01253 Ergonovine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB01274 Arformoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB01366 Procaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB01408 Bambuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB04948 Lofexidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB05039 Indacaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB06706 Isometheptene Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB06707 Levonordefrin Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00669 Sumatriptan Drug2 : DB08810 Cinitapride Pharmacological target (+,+) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB00725 Homatropine Methylbromide Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB00785 Cryptenamine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00674 Galantamine Drug2 : DB00805 Minaprine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00677 Isoflurophate Drug2 : DB00805 Minaprine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB00692 Phentolamine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB00699 Nicergoline Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB00797 Tolazoline Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB00831 Trifluoperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB00850 Perphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB00924 Cyclobenzaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB01038 Carphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB01063 Acetophenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB01184 Domperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00680 Moricizine Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00680 Moricizine Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00680 Moricizine Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB00794 Primidone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB00818 Propofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB00849 Methylphenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01351 Amobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01352 Aprobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01353 Butethal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01354 Heptabarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01355 Hexobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01440 Gamma Hydroxybutyric Acid Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01483 Barbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB00794 Primidone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB00818 Propofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB00849 Methylphenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01351 Amobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01352 Aprobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01353 Butethal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01354 Heptabarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01355 Hexobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01440 Gamma Hydroxybutyric Acid Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01483 Barbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB00831 Trifluoperazine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB00875 Flupentixol Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB01162 Terazosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB01392 Yohimbine Pharmacological target (-,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00694 Daunorubicin Drug2 : DB01179 Podofilox Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) Non-common off-target(s) (drug2) : BE0000143 Tubulin beta chain (-1) BE0001391 Tubulin alpha-4A chain (-1) --------------------------------------------------- Drug1 : DB00694 Daunorubicin Drug2 : DB04967 Lucanthone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) Non-common off-target(s) (drug2) : BE0000971 DNA topoisomerase 1 (-1) BE0002414 DNA-(apurinic or apyrimidinic site) lyase (-1) --------------------------------------------------- Drug1 : DB00695 Furosemide Drug2 : DB00887 Bumetanide Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000281 Solute carrier family 12 member 2 (-1) BE0000047 Solute carrier family 12 member 5 (-1) BE0000601 Solute carrier family 12 member 4 (-1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00695 Furosemide Drug2 : DB01325 Quinethazone Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000419 Solute carrier family 12 member 3 (-1) BE0000281 Solute carrier family 12 member 2 (-1) --------------------------------------------------- Drug1 : DB00696 Ergotamine Drug2 : DB00998 Frovatriptan Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00696 Ergotamine Drug2 : DB01253 Ergonovine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00696 Ergotamine Drug2 : DB06706 Isometheptene Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB00831 Trifluoperazine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB00875 Flupentixol Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB01162 Terazosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00700 Eplerenone Drug2 : DB01395 Drospirenone Pharmacological target (-,-) : BE0000668 Mineralocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (-1) --------------------------------------------------- Drug1 : DB00703 Methazolamide Drug2 : DB01325 Quinethazone Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Non-common off-target(s) (drug1) : BE0000535 Carbonic anhydrase 4 (-1) BE0003629 Carbonic anhydrase 7 (-1) Non-common off-target(s) (drug2) : BE0000502 Solute carrier family 12 member 1 (-1) BE0000419 Solute carrier family 12 member 3 (-1) BE0000281 Solute carrier family 12 member 2 (-1) --------------------------------------------------- Drug1 : DB00704 Naltrexone Drug2 : DB09049 Naloxegol Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00706 Tamsulosin Drug2 : DB00831 Trifluoperazine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00706 Tamsulosin Drug2 : DB00875 Flupentixol Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00710 Ibandronate Drug2 : DB00720 Clodronate Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0000776 Farnesyl pyrophosphate synthase (-1) Non-common off-target(s) (drug2) : BE0000599 ADP/ATP translocase 1 (-1) BE0000709 ADP/ATP translocase 2 (-1) BE0000624 ADP/ATP translocase 3 (-1) --------------------------------------------------- Drug1 : DB00712 Flurbiprofen Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00714 Apomorphine Drug2 : DB00915 Amantadine Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0000666 Neuron-specific vesicular protein calcyon (1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00715 Paroxetine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00715 Paroxetine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00720 Clodronate Drug2 : DB00884 Risedronate Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0000599 ADP/ATP translocase 1 (-1) BE0000709 ADP/ATP translocase 2 (-1) BE0000624 ADP/ATP translocase 3 (-1) Non-common off-target(s) (drug2) : BE0000776 Farnesyl pyrophosphate synthase (-1) --------------------------------------------------- Drug1 : DB00720 Clodronate Drug2 : DB01077 Etidronic acid Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0000599 ADP/ATP translocase 1 (-1) BE0000709 ADP/ATP translocase 2 (-1) BE0000624 ADP/ATP translocase 3 (-1) Non-common off-target(s) (drug2) : BE0003567 Receptor-type tyrosine-protein phosphatase S (-1) BE0003569 V-type proton ATPase catalytic subunit A (-1) --------------------------------------------------- Drug1 : DB00720 Clodronate Drug2 : DB01133 Tiludronate Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0000599 ADP/ATP translocase 1 (-1) BE0000709 ADP/ATP translocase 2 (-1) BE0000624 ADP/ATP translocase 3 (-1) Non-common off-target(s) (drug2) : BE0003569 V-type proton ATPase catalytic subunit A (-1) BE0000623 Tyrosine-protein phosphatase non-receptor type 1 (-1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB00745 Modafinil Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB00757 Dolasetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB00807 Proparacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB00830 Phenmetrazine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB00889 Granisetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB00892 Oxybuprocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB00904 Ondansetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB00915 Amantadine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB00937 Diethylpropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB00961 Mepivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB00969 Alosetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB01002 Levobupivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB01086 Benzocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB01221 Ketamine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000632 Kappa-type opioid receptor (1) BE0000384 Substance-P receptor (-1) BE0004957 5-hydroxytryptamine receptor 2 (-1) BE0004958 5-hydroxytryptamine receptor 1 (-1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB01255 Lisdexamfetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB01463 Fencamfamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB03575 Phencyclidine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB06701 Dexmethylphenidate Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00723 Methoxamine Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00723 Methoxamine Drug2 : DB00865 Benzphetamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00723 Methoxamine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB00728 Rocuronium Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB00729 Diphemanil Methylsulfate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00728 Rocuronium Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00728 Rocuronium Drug2 : DB00785 Cryptenamine Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00728 Rocuronium Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00728 Rocuronium Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00728 Rocuronium Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00728 Rocuronium Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00728 Rocuronium Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00729 Diphemanil Methylsulfate Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00729 Diphemanil Methylsulfate Drug2 : DB00785 Cryptenamine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00729 Diphemanil Methylsulfate Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00729 Diphemanil Methylsulfate Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00729 Diphemanil Methylsulfate Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00729 Diphemanil Methylsulfate Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00729 Diphemanil Methylsulfate Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00740 Riluzole Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00740 Riluzole Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (1) Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00740 Riluzole Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00744 Zileuton Drug2 : DB00795 Sulfasalazine Pharmacological target (-,-) : BE0000248 Arachidonate 5-lipoxygenase Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00744 Zileuton Drug2 : DB00939 Meclofenamic acid Pharmacological target (-,-) : BE0000248 Arachidonate 5-lipoxygenase Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) --------------------------------------------------- Drug1 : DB00744 Zileuton Drug2 : DB01014 Balsalazide Pharmacological target (-,-) : BE0000248 Arachidonate 5-lipoxygenase Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00745 Modafinil Drug2 : DB00852 Pseudoephedrine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00745 Modafinil Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00745 Modafinil Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00745 Modafinil Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00745 Modafinil Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00745 Modafinil Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00745 Modafinil Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00749 Etodolac Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00750 Prilocaine Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00750 Prilocaine Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00750 Prilocaine Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00752 Tranylcypromine Drug2 : DB00805 Minaprine Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00752 Tranylcypromine Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00752 Tranylcypromine Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00752 Tranylcypromine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00753 Isoflurane Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00753 Isoflurane Drug2 : DB00898 Ethanol Pharmacological target (+,+) : BE0000433 Glycine receptor subunit alpha-1 Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000745 Glycine receptor subunit alpha-2 (1) --------------------------------------------------- Drug1 : DB00753 Isoflurane Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00753 Isoflurane Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00753 Isoflurane Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00753 Isoflurane Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00753 Isoflurane Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00753 Isoflurane Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00753 Isoflurane Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00753 Isoflurane Drug2 : DB08883 Perampanel Pharmacological target (-,-) : BE0000640 Glutamate receptor 1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00754 Ethotoin Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00754 Ethotoin Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00754 Ethotoin Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00762 Irinotecan Drug2 : DB04967 Lucanthone Pharmacological target (-,-) : BE0000971 DNA topoisomerase 1 Non-common off-target(s) (drug1) : BE0000091 DNA topoisomerase I, mitochondrial (-1) Non-common off-target(s) (drug2) : BE0000742 DNA topoisomerase 2-alpha (-1) BE0002414 DNA-(apurinic or apyrimidinic site) lyase (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00770 Alprostadil Drug2 : DB00905 Bimatoprost Pharmacological target (+,+) : BE0000064 Prostaglandin E2 receptor EP1 subtype Non-common off-target(s) (drug1) : BE0000368 Prostaglandin E2 receptor EP2 subtype (1) Non-common off-target(s) (drug2) : BE0000610 Prostaglandin F2-alpha receptor (1) BE0002375 Prostaglandin E2 receptor EP3 subtype (1) --------------------------------------------------- Drug1 : DB00771 Clidinium Drug2 : DB00785 Cryptenamine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00771 Clidinium Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00771 Clidinium Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00771 Clidinium Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00771 Clidinium Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00771 Clidinium Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00773 Etoposide Drug2 : DB01179 Podofilox Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) Non-common off-target(s) (drug2) : BE0000143 Tubulin beta chain (-1) BE0001391 Tubulin alpha-4A chain (-1) --------------------------------------------------- Drug1 : DB00773 Etoposide Drug2 : DB04967 Lucanthone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) Non-common off-target(s) (drug2) : BE0000971 DNA topoisomerase 1 (-1) BE0002414 DNA-(apurinic or apyrimidinic site) lyase (-1) --------------------------------------------------- Drug1 : DB00774 Hydroflumethiazide Drug2 : DB00887 Bumetanide Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) Non-common off-target(s) (drug2) : BE0000281 Solute carrier family 12 member 2 (-1) BE0000047 Solute carrier family 12 member 5 (-1) BE0000601 Solute carrier family 12 member 4 (-1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00776 Oxcarbazepine Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00776 Oxcarbazepine Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00776 Oxcarbazepine Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00780 Phenelzine Drug2 : DB00805 Minaprine Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug1) : BE0000253 4-aminobutyrate aminotransferase, mitochondrial (-1) BE0000667 Alanine aminotransferase 1 (-1) BE0002166 Alanine aminotransferase 2 (-1) BE0002173 Glutamic acid decarboxylase (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0001002 Membrane primary amine oxidase (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00780 Phenelzine Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug1) : BE0000253 4-aminobutyrate aminotransferase, mitochondrial (-1) BE0000667 Alanine aminotransferase 1 (-1) BE0002166 Alanine aminotransferase 2 (-1) BE0002173 Glutamic acid decarboxylase (-1) BE0001002 Membrane primary amine oxidase (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00780 Phenelzine Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug1) : BE0000253 4-aminobutyrate aminotransferase, mitochondrial (-1) BE0000667 Alanine aminotransferase 1 (-1) BE0002166 Alanine aminotransferase 2 (-1) BE0002173 Glutamic acid decarboxylase (-1) BE0001002 Membrane primary amine oxidase (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00780 Phenelzine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug1) : BE0000253 4-aminobutyrate aminotransferase, mitochondrial (-1) BE0000667 Alanine aminotransferase 1 (-1) BE0002166 Alanine aminotransferase 2 (-1) BE0002173 Glutamic acid decarboxylase (-1) BE0001002 Membrane primary amine oxidase (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00782 Propantheline Drug2 : DB00785 Cryptenamine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00782 Propantheline Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00782 Propantheline Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00782 Propantheline Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00782 Propantheline Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00782 Propantheline Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00783 Estradiol Drug2 : DB01196 Estramustine Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) --------------------------------------------------- Drug1 : DB00783 Estradiol Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00784 Mefenamic acid Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00785 Cryptenamine Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00785 Cryptenamine Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00785 Cryptenamine Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00785 Cryptenamine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00785 Cryptenamine Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00785 Cryptenamine Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00785 Cryptenamine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00786 Marimastat Drug2 : DB01296 Glucosamine Pharmacological target (-,-) : BE0000058 Matrix metalloproteinase-9 Non-common off-target(s) (drug1) : BE0001198 Macrophage metalloelastase (-1) BE0000920 Interstitial collagenase (-1) BE0000642 72 kDa type IV collagenase (-1) BE0001116 Stromelysin-1 (-1) BE0003690 Matrilysin (-1) BE0001182 Neutrophil collagenase (-1) BE0003689 Stromelysin-2 (-1) BE0003691 Stromelysin-3 (-1) BE0000966 Collagenase 3 (-1) BE0003692 Matrix metalloproteinase-14 (-1) BE0003693 Matrix metalloproteinase-15 (-1) BE0001637 Matrix metalloproteinase-16 (-1) BE0003694 Matrix metalloproteinase-17 (-1) BE0003695 Matrix metalloproteinase-19 (-1) BE0003696 Matrix metalloproteinase-20 (-1) BE0003697 Matrix metalloproteinase-21 (-1) BE0003698 Matrix metalloproteinase-23 (-1) BE0003699 Matrix metalloproteinase-24 (-1) BE0003700 Matrix metalloproteinase-25 (-1) BE0003701 Matrix metalloproteinase-26 (-1) BE0003702 Matrix metalloproteinase-27 (-1) BE0003703 Matrix metalloproteinase-28 (-1) Non-common off-target(s) (drug2) : BE0002387 Nuclear factor NF-kappa-B p100 subunit (-1) --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB08814 Triflusal Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug1) : BE0000262 Prostaglandin G/H synthase 2 (-1) Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) BE0001086 Nuclear factor NF-kappa-B p105 subunit (-1) --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB00966 Telmisartan Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) Non-common off-target(s) (drug2) : BE0000062 Type-1 angiotensin II receptor (-1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB01132 Pioglitazone Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB08915 Aleglitazar Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) Non-common off-target(s) (drug2) : BE0000071 Peroxisome proliferator-activated receptor alpha (1) --------------------------------------------------- Drug1 : DB00797 Tolazoline Drug2 : DB00831 Trifluoperazine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00797 Tolazoline Drug2 : DB00875 Flupentixol Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00797 Tolazoline Drug2 : DB01162 Terazosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00797 Tolazoline Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00800 Fenoldopam Drug2 : DB00988 Dopamine Pharmacological target (+,+) : BE0000020 D(1A) dopamine receptor Pharmacological target (+,+) : BE0000145 D(1B) dopamine receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000756 D(2) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00800 Fenoldopam Drug2 : DB01235 L-DOPA Pharmacological target (+,+) : BE0000020 D(1A) dopamine receptor Pharmacological target (+,+) : BE0000145 D(1B) dopamine receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB00818 Propofol Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB00849 Methylphenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01351 Amobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01352 Aprobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01353 Butethal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01354 Heptabarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01355 Hexobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01440 Gamma Hydroxybutyric Acid Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01483 Barbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB00836 Loperamide Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB00843 Donepezil Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB00924 Cyclobenzaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB00944 Demecarium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB00981 Physostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB00989 Rivastigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB01010 Edrophonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB01122 Ambenonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB01171 Moclobemide Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB01247 Isocarboxazid Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB01400 Neostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB08996 Dimetacrine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00806 Pentoxifylline Drug2 : DB00820 Tadalafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0001096 5'-nucleotidase (-1) Non-common off-target(s) (drug2) : BE0003558 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (-1) --------------------------------------------------- Drug1 : DB00806 Pentoxifylline Drug2 : DB00824 Enprofylline Pharmacological target (-,-) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0001096 5'-nucleotidase (-1) Non-common off-target(s) (drug2) : BE0000241 Adenosine receptor A2b (-1) --------------------------------------------------- Drug1 : DB00806 Pentoxifylline Drug2 : DB00862 Vardenafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0001096 5'-nucleotidase (-1) --------------------------------------------------- Drug1 : DB00806 Pentoxifylline Drug2 : DB00975 Dipyridamole Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0001096 5'-nucleotidase (-1) Non-common off-target(s) (drug2) : BE0002214 Adenosine deaminase (-1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) --------------------------------------------------- Drug1 : DB00806 Pentoxifylline Drug2 : DB01113 Papaverine Pharmacological target (-,-) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Non-common off-target(s) (drug1) : BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0001096 5'-nucleotidase (-1) Non-common off-target(s) (drug2) : BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) --------------------------------------------------- Drug1 : DB00806 Pentoxifylline Drug2 : DB05266 Ibudilast Pharmacological target (-,-) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0001096 5'-nucleotidase (-1) Non-common off-target(s) (drug2) : BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) --------------------------------------------------- Drug1 : DB00806 Pentoxifylline Drug2 : DB06237 Avanafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0001096 5'-nucleotidase (-1) --------------------------------------------------- Drug1 : DB00806 Pentoxifylline Drug2 : DB06267 Udenafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0001096 5'-nucleotidase (-1) --------------------------------------------------- Drug1 : DB00806 Pentoxifylline Drug2 : DB06751 Drotaverine Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0001096 5'-nucleotidase (-1) Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00812 Phenylbutazone Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000117 Prostacyclin synthase (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00812 Phenylbutazone Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00812 Phenylbutazone Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000117 Prostacyclin synthase (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00812 Phenylbutazone Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00814 Meloxicam Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB01064 Isoprenaline Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB01363 Ephedra Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00818 Propofol Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00818 Propofol Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00818 Propofol Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00818 Propofol Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00818 Propofol Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00818 Propofol Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00818 Propofol Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00818 Propofol Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00818 Propofol Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00818 Propofol Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00818 Propofol Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00818 Propofol Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00818 Propofol Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00818 Propofol Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00818 Propofol Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00819 Acetazolamide Drug2 : DB01031 Ethinamate Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Non-common off-target(s) (drug1) : BE0000535 Carbonic anhydrase 4 (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000880 Aquaporin-1 (-1) --------------------------------------------------- Drug1 : DB00819 Acetazolamide Drug2 : DB01119 Diazoxide Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Non-common off-target(s) (drug1) : BE0000535 Carbonic anhydrase 4 (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000880 Aquaporin-1 (-1) Non-common off-target(s) (drug2) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (1) --------------------------------------------------- Drug1 : DB00820 Tadalafil Drug2 : DB00975 Dipyridamole Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0003558 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (-1) Non-common off-target(s) (drug2) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002214 Adenosine deaminase (-1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) --------------------------------------------------- Drug1 : DB00821 Carprofen Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00823 Ethynodiol Drug2 : DB01196 Estramustine Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) --------------------------------------------------- Drug1 : DB00823 Ethynodiol Drug2 : DB01395 Drospirenone Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) Non-common off-target(s) (drug2) : BE0000132 Androgen receptor (-1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00823 Ethynodiol Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00824 Enprofylline Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000241 Adenosine receptor A2b (-1) Non-common off-target(s) (drug2) : BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0000442 Histamine H1 receptor (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00824 Enprofylline Drug2 : DB01113 Papaverine Pharmacological target (-,-) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Non-common off-target(s) (drug1) : BE0000241 Adenosine receptor A2b (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) Non-common off-target(s) (drug2) : BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) --------------------------------------------------- Drug1 : DB00824 Enprofylline Drug2 : DB06751 Drotaverine Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000241 Adenosine receptor A2b (-1) Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB00849 Methylphenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01351 Amobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01352 Aprobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01353 Butethal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01354 Heptabarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01355 Hexobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01440 Gamma Hydroxybutyric Acid Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01483 Barbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB00852 Pseudoephedrine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB01063 Acetophenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB01136 Carvedilol Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000173 NADH dehydrogenase [ubiquinone] 1 subunit C2 (-1) BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0001114 Vascular cell adhesion protein 1 (-1) BE0001074 E-selectin (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB01184 Domperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB01618 Molindone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB04842 Fluspirilene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB06207 Silodosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB06288 Amisulpride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00836 Loperamide Drug2 : DB00913 Anileridine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00836 Loperamide Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00836 Loperamide Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00836 Loperamide Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00836 Loperamide Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB00849 Methylphenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB00898 Ethanol Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000745 Glycine receptor subunit alpha-2 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01028 Methoxyflurane Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01154 Thiamylal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01351 Amobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01352 Aprobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01353 Butethal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01354 Heptabarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01355 Hexobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01483 Barbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00839 Tolazamide Drug2 : DB08838 Agmatine Pharmacological target (-,-) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 Non-common off-target(s) (drug2) : BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000342 Alpha-2C adrenergic receptor (1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0004661 Acetylcholine receptor subunit alpha (-1) BE0003580 Nischarin (1) BE0004768 Acid-sensing ion channel 3 (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB00849 Methylphenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01351 Amobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01352 Aprobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01353 Butethal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01354 Heptabarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01355 Hexobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01440 Gamma Hydroxybutyric Acid Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01483 Barbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00844 Nalbuphine Drug2 : DB09049 Naloxegol Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00849 Methylphenobarbital Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00849 Methylphenobarbital Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00849 Methylphenobarbital Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00849 Methylphenobarbital Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00849 Methylphenobarbital Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00849 Methylphenobarbital Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00849 Methylphenobarbital Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00849 Methylphenobarbital Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00849 Methylphenobarbital Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00849 Methylphenobarbital Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00849 Methylphenobarbital Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00849 Methylphenobarbital Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00849 Methylphenobarbital Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB01239 Chlorprothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB00934 Maprotiline Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB00935 Oxymetazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB00937 Diethylpropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB00964 Apraclonidine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB01018 Guanfacine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB01253 Ergonovine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB01255 Lisdexamfetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB01463 Fencamfamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB01576 Dextroamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB01577 Methamphetamine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB01579 Phendimetrazine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB04948 Lofexidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB06694 Xylometazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB06706 Isometheptene Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00858 Drostanolone Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000123 Estrogen receptor (-1) --------------------------------------------------- Drug1 : DB00858 Drostanolone Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00861 Diflunisal Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00862 Vardenafil Drug2 : DB00975 Dipyridamole Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug2) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002214 Adenosine deaminase (-1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) --------------------------------------------------- Drug1 : DB00863 Ranitidine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB01018 Guanfacine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB01253 Ergonovine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB01579 Phendimetrazine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB04948 Lofexidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB06707 Levonordefrin Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB01297 Practolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB01359 Penbutolol Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000797 5-hydroxytryptamine receptor 1B (-1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB01616 Alverine Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00867 Ritodrine Drug2 : DB01064 Isoprenaline Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB00867 Ritodrine Drug2 : DB01363 Ephedra Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00867 Ritodrine Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00870 Suprofen Drug2 : DB08814 Triflusal Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug1) : BE0000262 Prostaglandin G/H synthase 2 (-1) Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) BE0001086 Nuclear factor NF-kappa-B p105 subunit (-1) --------------------------------------------------- Drug1 : DB00870 Suprofen Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00871 Terbutaline Drug2 : DB01064 Isoprenaline Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB00871 Terbutaline Drug2 : DB01363 Ephedra Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00871 Terbutaline Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB00924 Cyclobenzaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB00925 Phenoxybenzamine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB01136 Carvedilol Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000173 NADH dehydrogenase [ubiquinone] 1 subunit C2 (-1) BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0001114 Vascular cell adhesion protein 1 (-1) BE0001074 E-selectin (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB01184 Domperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB01608 Propericiazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB06207 Silodosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00880 Chlorothiazide Drug2 : DB01324 Polythiazide Pharmacological target (-,-) : BE0000419 Solute carrier family 12 member 3 Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) --------------------------------------------------- Drug1 : DB00887 Bumetanide Drug2 : DB00903 Ethacrynic acid Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug1) : BE0000281 Solute carrier family 12 member 2 (-1) BE0000047 Solute carrier family 12 member 5 (-1) BE0000601 Solute carrier family 12 member 4 (-1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) Non-common off-target(s) (drug2) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 (-1) --------------------------------------------------- Drug1 : DB00887 Bumetanide Drug2 : DB01021 Trichlormethiazide Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug1) : BE0000281 Solute carrier family 12 member 2 (-1) BE0000047 Solute carrier family 12 member 5 (-1) BE0000601 Solute carrier family 12 member 4 (-1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 (-1) --------------------------------------------------- Drug1 : DB00887 Bumetanide Drug2 : DB01325 Quinethazone Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Pharmacological target (-,-) : BE0000281 Solute carrier family 12 member 2 Non-common off-target(s) (drug1) : BE0000047 Solute carrier family 12 member 5 (-1) BE0000601 Solute carrier family 12 member 4 (-1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000419 Solute carrier family 12 member 3 (-1) --------------------------------------------------- Drug1 : DB00890 Dienestrol Drug2 : DB01196 Estramustine Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) --------------------------------------------------- Drug1 : DB00890 Dienestrol Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01351 Amobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01352 Aprobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01353 Butethal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01354 Heptabarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01355 Hexobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01440 Gamma Hydroxybutyric Acid Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01483 Barbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00898 Ethanol Drug2 : DB00915 Amantadine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (1) BE0000745 Glycine receptor subunit alpha-2 (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00898 Ethanol Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000745 Glycine receptor subunit alpha-2 (1) --------------------------------------------------- Drug1 : DB00898 Ethanol Drug2 : DB01028 Methoxyflurane Pharmacological target (+,+) : BE0000433 Glycine receptor subunit alpha-1 Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000745 Glycine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00898 Ethanol Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000745 Glycine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00898 Ethanol Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000745 Glycine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00898 Ethanol Drug2 : DB01221 Ketamine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (1) BE0000745 Glycine receptor subunit alpha-2 (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000632 Kappa-type opioid receptor (1) BE0000384 Substance-P receptor (-1) BE0004957 5-hydroxytryptamine receptor 2 (-1) BE0004958 5-hydroxytryptamine receptor 1 (-1) --------------------------------------------------- Drug1 : DB00898 Ethanol Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0000433 Glycine receptor subunit alpha-1 Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000745 Glycine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00898 Ethanol Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000745 Glycine receptor subunit alpha-2 (1) --------------------------------------------------- Drug1 : DB00898 Ethanol Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000745 Glycine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00898 Ethanol Drug2 : DB03575 Phencyclidine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (1) BE0000745 Glycine receptor subunit alpha-2 (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00903 Ethacrynic acid Drug2 : DB01325 Quinethazone Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug1) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 (-1) Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000419 Solute carrier family 12 member 3 (-1) BE0000281 Solute carrier family 12 member 2 (-1) --------------------------------------------------- Drug1 : DB00905 Bimatoprost Drug2 : DB00929 Misoprostol Pharmacological target (+,+) : BE0002375 Prostaglandin E2 receptor EP3 subtype Non-common off-target(s) (drug1) : BE0000610 Prostaglandin F2-alpha receptor (1) BE0000064 Prostaglandin E2 receptor EP1 subtype (1) Non-common off-target(s) (drug2) : BE0000368 Prostaglandin E2 receptor EP2 subtype (1) BE0003522 Prostaglandin E2 receptor EP4 subtype (1) --------------------------------------------------- Drug1 : DB00905 Bimatoprost Drug2 : DB01088 Iloprost Pharmacological target (+,+) : BE0000064 Prostaglandin E2 receptor EP1 subtype Non-common off-target(s) (drug1) : BE0000610 Prostaglandin F2-alpha receptor (1) BE0002375 Prostaglandin E2 receptor EP3 subtype (1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (1) BE0000475 Prostacyclin receptor (1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (1) --------------------------------------------------- Drug1 : DB00905 Bimatoprost Drug2 : DB01160 Dinoprost Tromethamine Pharmacological target (+,+) : BE0000610 Prostaglandin F2-alpha receptor Non-common off-target(s) (drug1) : BE0000064 Prostaglandin E2 receptor EP1 subtype (1) BE0002375 Prostaglandin E2 receptor EP3 subtype (1) Non-common off-target(s) (drug2) : BE0000475 Prostacyclin receptor (-1) --------------------------------------------------- Drug1 : DB00905 Bimatoprost Drug2 : DB08819 Tafluprost Pharmacological target (+,+) : BE0000610 Prostaglandin F2-alpha receptor Non-common off-target(s) (drug1) : BE0000064 Prostaglandin E2 receptor EP1 subtype (1) BE0002375 Prostaglandin E2 receptor EP3 subtype (1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB00908 Quinidine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01255 Lisdexamfetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01463 Fencamfamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00908 Quinidine Drug2 : DB00909 Zonisamide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00909 Zonisamide Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00909 Zonisamide Drug2 : DB01121 Phenacemide Pharmacological target (-,-) : BE0000141 Sodium channel protein type 1 subunit alpha Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00909 Zonisamide Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00909 Zonisamide Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Pharmacological target (-,-) : BE0002083 Sodium channel protein type 4 subunit alpha Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00909 Zonisamide Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00909 Zonisamide Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00909 Zonisamide Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00909 Zonisamide Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00909 Zonisamide Drug2 : DB01438 Phenazopyridine Pharmacological target (-,-) : BE0000141 Sodium channel protein type 1 subunit alpha Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00909 Zonisamide Drug2 : DB04841 Flunarizine Pharmacological target (-,-) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G Pharmacological target (-,-) : BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00909 Zonisamide Drug2 : DB04930 Permethrin Pharmacological target (-,-) : BE0000141 Sodium channel protein type 1 subunit alpha Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00909 Zonisamide Drug2 : DB05246 Methsuximide Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0003629 Carbonic anhydrase 7 (-1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) BE0002082 Sodium channel protein type 3 subunit alpha (-1) BE0003635 Sodium channel subunit beta-1 (-1) BE0003636 Sodium channel subunit beta-2 (-1) BE0003637 Sodium channel subunit beta-3 (-1) BE0003638 Sodium channel subunit beta-4 (-1) BE0003626 Carbonic anhydrase 5A, mitochondrial (-1) BE0003627 Carbonic anhydrase 5B, mitochondrial (-1) BE0003628 Carbonic anhydrase 6 (-1) BE0003630 Carbonic anhydrase-related protein (-1) BE0003631 Carbonic anhydrase-related protein 10 (-1) BE0003632 Carbonic anhydrase-related protein 11 (-1) BE0003633 Carbonic anhydrase 13 (-1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB00949 Felbamate Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB00988 Dopamine Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01235 L-DOPA Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01520 Tenocyclidine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000454 Glutamate receptor ionotropic, NMDA 2C (-1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB05271 Rotigotine Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000572 Alpha-2B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00917 Dinoprostone Drug2 : DB01088 Iloprost Pharmacological target (+,+) : BE0000064 Prostaglandin E2 receptor EP1 subtype Non-common off-target(s) (drug1) : BE0000368 Prostaglandin E2 receptor EP2 subtype (1) BE0002375 Prostaglandin E2 receptor EP3 subtype (1) BE0003522 Prostaglandin E2 receptor EP4 subtype (1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (1) BE0000475 Prostacyclin receptor (1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB01113 Papaverine Pharmacological target (-,-) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Non-common off-target(s) (drug1) : BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0000442 Histamine H1 receptor (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) Non-common off-target(s) (drug2) : BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB06751 Drotaverine Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0000442 Histamine H1 receptor (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB01149 Nefazodone Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB01239 Chlorprothixene Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB01242 Clomipramine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000814 Glutathione S-transferase P (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB01267 Paliperidone Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00926 Etretinate Drug2 : DB04942 Tamibarotene Pharmacological target (+,+) : BE0000206 Retinoic acid receptor beta Pharmacological target (+,+) : BE0000663 Retinoic acid receptor alpha Non-common off-target(s) (drug1) : BE0000144 Retinoic acid receptor gamma (1) BE0000707 Retinoic acid receptor RXR-gamma (1) BE0000078 Retinoic acid receptor RXR-beta (1) BE0000412 Retinoic acid receptor RXR-alpha (1) --------------------------------------------------- Drug1 : DB00927 Famotidine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01038 Carphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01100 Pimozide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000581 D(3) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01149 Nefazodone Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01239 Chlorprothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01242 Clomipramine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000814 Glutathione S-transferase P (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01267 Paliperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00934 Maprotiline Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00934 Maprotiline Drug2 : DB01149 Nefazodone Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00934 Maprotiline Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00934 Maprotiline Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00934 Maprotiline Drug2 : DB01454 3,4-Methylenedioxymethamphetamine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00934 Maprotiline Drug2 : DB01576 Dextroamphetamine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00934 Maprotiline Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00935 Oxymetazoline Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00936 Salicylic acid Drug2 : DB08814 Triflusal Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug1) : BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) BE0001086 Nuclear factor NF-kappa-B p105 subunit (-1) --------------------------------------------------- Drug1 : DB00936 Salicylic acid Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00938 Salmeterol Drug2 : DB01064 Isoprenaline Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB00938 Salmeterol Drug2 : DB01363 Ephedra Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00938 Salmeterol Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00939 Meclofenamic acid Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00939 Meclofenamic acid Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00939 Meclofenamic acid Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00939 Meclofenamic acid Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00942 Cycrimine Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00942 Cycrimine Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00942 Cycrimine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00942 Cycrimine Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00942 Cycrimine Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00945 Acetylsalicylic acid Drug2 : DB08814 Triflusal Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug1) : BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) BE0001086 Nuclear factor NF-kappa-B p105 subunit (-1) --------------------------------------------------- Drug1 : DB00945 Acetylsalicylic acid Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00947 Fulvestrant Drug2 : DB01185 Fluoxymesterone Pharmacological target (-,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00949 Felbamate Drug2 : DB01221 Ketamine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000632 Kappa-type opioid receptor (1) BE0000384 Substance-P receptor (-1) BE0004957 5-hydroxytryptamine receptor 2 (-1) BE0004958 5-hydroxytryptamine receptor 1 (-1) --------------------------------------------------- Drug1 : DB00949 Felbamate Drug2 : DB03575 Phencyclidine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) --------------------------------------------------- Drug1 : DB00949 Felbamate Drug2 : DB08954 Ifenprodil Pharmacological target (-,-) : BE0000417 Glutamate receptor ionotropic, NMDA 2B Non-common off-target(s) (drug1) : BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00952 Naratriptan Drug2 : DB08810 Cinitapride Pharmacological target (+,+) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00957 Norgestimate Drug2 : DB01196 Estramustine Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) --------------------------------------------------- Drug1 : DB00957 Norgestimate Drug2 : DB01395 Drospirenone Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) Non-common off-target(s) (drug2) : BE0000132 Androgen receptor (-1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00957 Norgestimate Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01028 Methoxyflurane Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01154 Thiamylal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01351 Amobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01352 Aprobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01353 Butethal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01354 Heptabarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01355 Hexobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01483 Barbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00963 Bromfenac Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00964 Apraclonidine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00966 Telmisartan Drug2 : DB01014 Balsalazide Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000062 Type-1 angiotensin II receptor (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00966 Telmisartan Drug2 : DB01393 Bezafibrate Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000062 Type-1 angiotensin II receptor (-1) Non-common off-target(s) (drug2) : BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000071 Peroxisome proliferator-activated receptor alpha (1) --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00975 Dipyridamole Drug2 : DB06237 Avanafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002214 Adenosine deaminase (-1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) --------------------------------------------------- Drug1 : DB00975 Dipyridamole Drug2 : DB06267 Udenafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002214 Adenosine deaminase (-1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) --------------------------------------------------- Drug1 : DB00975 Dipyridamole Drug2 : DB06751 Drotaverine Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0002214 Adenosine deaminase (-1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) --------------------------------------------------- Drug1 : DB00977 Ethinyl Estradiol Drug2 : DB01196 Estramustine Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) Non-common off-target(s) (drug2) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) --------------------------------------------------- Drug1 : DB00977 Ethinyl Estradiol Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00979 Cyclopentolate Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00979 Cyclopentolate Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00979 Cyclopentolate Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00979 Cyclopentolate Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00979 Cyclopentolate Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00983 Formoterol Drug2 : DB01064 Isoprenaline Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB00983 Formoterol Drug2 : DB01363 Ephedra Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00983 Formoterol Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00984 Nandrolone phenpropionate Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000123 Estrogen receptor (-1) --------------------------------------------------- Drug1 : DB00984 Nandrolone phenpropionate Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00991 Oxaprozin Drug2 : DB08814 Triflusal Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug1) : BE0000262 Prostaglandin G/H synthase 2 (-1) Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) BE0001086 Nuclear factor NF-kappa-B p105 subunit (-1) --------------------------------------------------- Drug1 : DB00991 Oxaprozin Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB00996 Gabapentin Drug2 : DB01202 Levetiracetam Pharmacological target (-,-) : BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B Non-common off-target(s) (drug1) : BE0000013 Adenosine receptor A1 (1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000993 Synaptic vesicle glycoprotein 2A (1) --------------------------------------------------- Drug1 : DB00997 Doxorubicin Drug2 : DB01179 Podofilox Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0000143 Tubulin beta chain (-1) BE0001391 Tubulin alpha-4A chain (-1) --------------------------------------------------- Drug1 : DB00997 Doxorubicin Drug2 : DB04967 Lucanthone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0000971 DNA topoisomerase 1 (-1) BE0002414 DNA-(apurinic or apyrimidinic site) lyase (-1) --------------------------------------------------- Drug1 : DB01005 Hydroxyurea Drug2 : DB01073 Fludarabine Pharmacological target (-,-) : BE0000325 Ribonucleoside-diphosphate reductase large subunit Non-common off-target(s) (drug2) : BE0000546 DNA polymerase alpha catalytic subunit (-1) BE0002804 Deoxycytidine kinase (1) --------------------------------------------------- Drug1 : DB01009 Ketoprofen Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB01014 Balsalazide Drug2 : DB01132 Pioglitazone Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB01014 Balsalazide Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB01014 Balsalazide Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB01014 Balsalazide Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB01014 Balsalazide Drug2 : DB08915 Aleglitazar Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) Non-common off-target(s) (drug2) : BE0000071 Peroxisome proliferator-activated receptor alpha (1) --------------------------------------------------- Drug1 : DB01018 Guanfacine Drug2 : DB01363 Ephedra Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01018 Guanfacine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01018 Guanfacine Drug2 : DB01577 Methamphetamine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01018 Guanfacine Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01018 Guanfacine Drug2 : DB06694 Xylometazoline Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01019 Bethanechol Drug2 : DB01085 Pilocarpine Pharmacological target (+,+) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) --------------------------------------------------- Drug1 : DB01028 Methoxyflurane Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB01028 Methoxyflurane Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB01028 Methoxyflurane Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB01028 Methoxyflurane Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01028 Methoxyflurane Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB01028 Methoxyflurane Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB01028 Methoxyflurane Drug2 : DB08883 Perampanel Pharmacological target (-,-) : BE0000640 Glutamate receptor 1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB01030 Topotecan Drug2 : DB04967 Lucanthone Pharmacological target (-,-) : BE0000971 DNA topoisomerase 1 Non-common off-target(s) (drug1) : BE0000091 DNA topoisomerase I, mitochondrial (-1) Non-common off-target(s) (drug2) : BE0000742 DNA topoisomerase 2-alpha (-1) BE0002414 DNA-(apurinic or apyrimidinic site) lyase (-1) --------------------------------------------------- Drug1 : DB01031 Ethinamate Drug2 : DB01325 Quinethazone Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Non-common off-target(s) (drug2) : BE0000502 Solute carrier family 12 member 1 (-1) BE0000419 Solute carrier family 12 member 3 (-1) BE0000281 Solute carrier family 12 member 2 (-1) --------------------------------------------------- Drug1 : DB01034 Cerulenin Drug2 : DB01083 Orlistat Pharmacological target (-,-) : BE0000959 Fatty acid synthase Non-common off-target(s) (drug2) : BE0000683 Pancreatic triacylglycerol lipase (-1) BE0003620 Gastric triacylglycerol lipase (-1) --------------------------------------------------- Drug1 : DB01036 Tolterodine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01036 Tolterodine Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01036 Tolterodine Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01036 Tolterodine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB01038 Carphenazine Drug2 : DB01184 Domperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01038 Carphenazine Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01038 Carphenazine Drug2 : DB01239 Chlorprothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000145 D(1B) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01038 Carphenazine Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01038 Carphenazine Drug2 : DB01608 Propericiazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01038 Carphenazine Drug2 : DB01618 Molindone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01038 Carphenazine Drug2 : DB04842 Fluspirilene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB01038 Carphenazine Drug2 : DB06288 Amisulpride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01038 Carphenazine Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01038 Carphenazine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01039 Fenofibrate Drug2 : DB01393 Bezafibrate Pharmacological target (+,+) : BE0000071 Peroxisome proliferator-activated receptor alpha Non-common off-target(s) (drug1) : BE0001020 Metalloproteinase (-1) Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) --------------------------------------------------- Drug1 : DB01041 Thalidomide Drug2 : DB08904 Certolizumab pegol Pharmacological target (-,-) : BE0000704 Tumor necrosis factor Non-common off-target(s) (drug1) : BE0000748 Fibroblast growth factor receptor 2 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0004755 Protein cereblon (-1) BE0001086 Nuclear factor NF-kappa-B p105 subunit (-1) --------------------------------------------------- Drug1 : DB01043 Memantine Drug2 : DB03575 Phencyclidine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000756 D(2) dopamine receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB01043 Memantine Drug2 : DB08954 Ifenprodil Pharmacological target (-,-) : BE0000417 Glutamate receptor ionotropic, NMDA 2B Non-common off-target(s) (drug1) : BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000756 D(2) dopamine receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) --------------------------------------------------- Drug1 : DB01050 Ibuprofen Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB01056 Tocainide Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB01062 Oxybutynin Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01062 Oxybutynin Drug2 : DB01625 Isopropamide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB01062 Oxybutynin Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB01063 Acetophenazine Drug2 : DB01100 Pimozide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000581 D(3) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01063 Acetophenazine Drug2 : DB01239 Chlorprothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01063 Acetophenazine Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB01064 Isoprenaline Drug2 : DB01274 Arformoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB01064 Isoprenaline Drug2 : DB01363 Ephedra Pharmacological target (+,+) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Pharmacological target (+,+) : BE0001012 Beta-3 adrenergic receptor Non-common off-target(s) (drug1) : BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01064 Isoprenaline Drug2 : DB01366 Procaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB01064 Isoprenaline Drug2 : DB01408 Bambuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB01064 Isoprenaline Drug2 : DB05039 Indacaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB01064 Isoprenaline Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Pharmacological target (+,+) : BE0001012 Beta-3 adrenergic receptor Non-common off-target(s) (drug1) : BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01064 Isoprenaline Drug2 : DB08893 Mirabegron Pharmacological target (+,+) : BE0001012 Beta-3 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB01064 Isoprenaline Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB01068 Clonazepam Drug2 : DB01189 Desflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB01068 Clonazepam Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB01068 Clonazepam Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01068 Clonazepam Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB01068 Clonazepam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01068 Clonazepam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01085 Pilocarpine Drug2 : DB01233 Metoclopramide Pharmacological target (+,+) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01085 Pilocarpine Drug2 : DB06709 Methacholine Pharmacological target (+,+) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB01088 Iloprost Drug2 : DB01240 Epoprostenol Pharmacological target (+,+) : BE0000475 Prostacyclin receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (1) BE0000064 Prostaglandin E2 receptor EP1 subtype (1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (1) Non-common off-target(s) (drug2) : BE0000110 P2Y purinoceptor 12 (1) BE0000117 Prostacyclin synthase (1) --------------------------------------------------- Drug1 : DB01089 Deserpidine Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01089 Deserpidine Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01089 Deserpidine Drug2 : DB01454 3,4-Methylenedioxymethamphetamine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01089 Deserpidine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01089 Deserpidine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01090 Pentolinium Drug2 : DB01116 Trimethaphan Pharmacological target (-,-) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) BE0003584 Neuronal acetylcholine receptor subunit beta-4 (-1) --------------------------------------------------- Drug1 : DB01100 Pimozide Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000090 Potassium voltage-gated channel subfamily H member 2 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01100 Pimozide Drug2 : DB01218 Halofantrine Pharmacological target (-,-) : BE0000090 Potassium voltage-gated channel subfamily H member 2 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01100 Pimozide Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000581 D(3) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01100 Pimozide Drug2 : DB01239 Chlorprothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01100 Pimozide Drug2 : DB01267 Paliperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01100 Pimozide Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000581 D(3) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01100 Pimozide Drug2 : DB01618 Molindone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000581 D(3) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01100 Pimozide Drug2 : DB04842 Fluspirilene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000581 D(3) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB01100 Pimozide Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000581 D(3) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01100 Pimozide Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000581 D(3) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01104 Sertraline Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01104 Sertraline Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB01104 Sertraline Drug2 : DB01242 Clomipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000814 Glutathione S-transferase P (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01104 Sertraline Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01105 Sibutramine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01105 Sibutramine Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) --------------------------------------------------- Drug1 : DB01105 Sibutramine Drug2 : DB01255 Lisdexamfetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01105 Sibutramine Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01105 Sibutramine Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01105 Sibutramine Drug2 : DB01463 Fencamfamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01105 Sibutramine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01105 Sibutramine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01105 Sibutramine Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01154 Thiamylal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01189 Desflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01351 Amobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01352 Aprobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01353 Butethal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01354 Heptabarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01355 Hexobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01483 Barbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01113 Papaverine Drug2 : DB05266 Ibudilast Pharmacological target (-,-) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Non-common off-target(s) (drug1) : BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) Non-common off-target(s) (drug2) : BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) --------------------------------------------------- Drug1 : DB01118 Amiodarone Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000090 Potassium voltage-gated channel subfamily H member 2 Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01118 Amiodarone Drug2 : DB01203 Nadolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01118 Amiodarone Drug2 : DB01210 Levobunolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01118 Amiodarone Drug2 : DB01214 Metipranolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01118 Amiodarone Drug2 : DB01218 Halofantrine Pharmacological target (-,-) : BE0000090 Potassium voltage-gated channel subfamily H member 2 Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB01118 Amiodarone Drug2 : DB01295 Bevantolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01118 Amiodarone Drug2 : DB01297 Practolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB01118 Amiodarone Drug2 : DB01580 Oxprenolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01118 Amiodarone Drug2 : DB04861 Nebivolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01118 Amiodarone Drug2 : DB08808 Bupranolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) BE0001012 Beta-3 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01119 Diazoxide Drug2 : DB01325 Quinethazone Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Non-common off-target(s) (drug1) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (1) Non-common off-target(s) (drug2) : BE0000502 Solute carrier family 12 member 1 (-1) BE0000419 Solute carrier family 12 member 3 (-1) BE0000281 Solute carrier family 12 member 2 (-1) --------------------------------------------------- Drug1 : DB01128 Bicalutamide Drug2 : DB01395 Drospirenone Pharmacological target (-,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB01132 Pioglitazone Drug2 : DB01393 Bezafibrate Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug2) : BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000071 Peroxisome proliferator-activated receptor alpha (1) --------------------------------------------------- Drug1 : DB01137 Levofloxacin Drug2 : DB01179 Podofilox Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0000143 Tubulin beta chain (-1) BE0001391 Tubulin alpha-4A chain (-1) --------------------------------------------------- Drug1 : DB01137 Levofloxacin Drug2 : DB04967 Lucanthone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0000971 DNA topoisomerase 1 (-1) BE0002414 DNA-(apurinic or apyrimidinic site) lyase (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB01359 Penbutolol Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0000797 5-hydroxytryptamine receptor 1B (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB01616 Alverine Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB08805 Metiamide Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB08806 Roxatidine acetate Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01144 Diclofenamide Drug2 : DB01325 Quinethazone Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Non-common off-target(s) (drug1) : BE0000535 Carbonic anhydrase 4 (-1) BE0003629 Carbonic anhydrase 7 (-1) Non-common off-target(s) (drug2) : BE0000502 Solute carrier family 12 member 1 (-1) BE0000419 Solute carrier family 12 member 3 (-1) BE0000281 Solute carrier family 12 member 2 (-1) --------------------------------------------------- Drug1 : DB01146 Diphenylpyraline Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01146 Diphenylpyraline Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01148 Flavoxate Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01149 Nefazodone Drug2 : DB01359 Penbutolol Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000797 5-hydroxytryptamine receptor 1B (-1) --------------------------------------------------- Drug1 : DB01149 Nefazodone Drug2 : DB01616 Alverine Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01149 Nefazodone Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01149 Nefazodone Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01149 Nefazodone Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB01149 Nefazodone Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01149 Nefazodone Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01149 Nefazodone Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB01151 Desipramine Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB01151 Desipramine Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) --------------------------------------------------- Drug1 : DB01151 Desipramine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01151 Desipramine Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01151 Desipramine Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01151 Desipramine Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01154 Thiamylal Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01154 Thiamylal Drug2 : DB01251 Gliquidone Pharmacological target (-,-) : BE0002441 ATP-sensitive inward rectifier potassium channel 8 Non-common off-target(s) (drug1) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000207 ATP-binding cassette sub-family C member 8 (-1) --------------------------------------------------- Drug1 : DB01154 Thiamylal Drug2 : DB01289 Glisoxepide Pharmacological target (-,-) : BE0002441 ATP-sensitive inward rectifier potassium channel 8 Non-common off-target(s) (drug1) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB01154 Thiamylal Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) --------------------------------------------------- Drug1 : DB01154 Thiamylal Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01156 Bupropion Drug2 : DB01173 Orphenadrine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01156 Bupropion Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01156 Bupropion Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01156 Bupropion Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01156 Bupropion Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01159 Halothane Drug2 : DB01189 Desflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB01159 Halothane Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB01159 Halothane Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01159 Halothane Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB01159 Halothane Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01159 Halothane Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01162 Terazosin Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01166 Cilostazol Drug2 : DB01223 Aminophylline Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug2) : BE0000013 Adenosine receptor A1 (-1) BE0002366 Histone deacetylase 2 (1) BE0000354 Adenosine receptor A3 (-1) --------------------------------------------------- Drug1 : DB01166 Cilostazol Drug2 : DB01303 Oxtriphylline Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug2) : BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0002366 Histone deacetylase 2 (1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB01171 Moclobemide Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01171 Moclobemide Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01171 Moclobemide Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB01221 Ketamine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000632 Kappa-type opioid receptor (1) BE0000384 Substance-P receptor (-1) BE0004957 5-hydroxytryptamine receptor 2 (-1) BE0004958 5-hydroxytryptamine receptor 1 (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB03575 Phencyclidine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB06204 Tapentadol Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000770 Mu-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB06701 Dexmethylphenidate Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB08954 Ifenprodil Pharmacological target (-,-) : BE0000365 Glutamate receptor ionotropic, NMDA 1 Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) --------------------------------------------------- Drug1 : DB01174 Phenobarbital Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB01174 Phenobarbital Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01174 Phenobarbital Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB01174 Phenobarbital Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01174 Phenobarbital Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01174 Phenobarbital Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01174 Phenobarbital Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) --------------------------------------------------- Drug1 : DB01174 Phenobarbital Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01174 Phenobarbital Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01174 Phenobarbital Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01174 Phenobarbital Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01176 Cyclizine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000951 Estrogen sulfotransferase (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01177 Idarubicin Drug2 : DB01179 Podofilox Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0000143 Tubulin beta chain (-1) BE0001391 Tubulin alpha-4A chain (-1) --------------------------------------------------- Drug1 : DB01177 Idarubicin Drug2 : DB04967 Lucanthone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0000971 DNA topoisomerase 1 (-1) BE0002414 DNA-(apurinic or apyrimidinic site) lyase (-1) --------------------------------------------------- Drug1 : DB01178 Chlormezanone Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000736 Translocator protein Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01178 Chlormezanone Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000736 Translocator protein Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) --------------------------------------------------- Drug1 : DB01179 Podofilox Drug2 : DB01204 Mitoxantrone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000143 Tubulin beta chain (-1) BE0001391 Tubulin alpha-4A chain (-1) --------------------------------------------------- Drug1 : DB01179 Podofilox Drug2 : DB01208 Sparfloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000143 Tubulin beta chain (-1) BE0001391 Tubulin alpha-4A chain (-1) --------------------------------------------------- Drug1 : DB01179 Podofilox Drug2 : DB01394 Colchicine Pharmacological target (-,-) : BE0000143 Tubulin beta chain Non-common off-target(s) (drug1) : BE0000742 DNA topoisomerase 2-alpha (-1) BE0001391 Tubulin alpha-4A chain (-1) Non-common off-target(s) (drug2) : BE0000026 Tubulin beta-1 chain (-1) --------------------------------------------------- Drug1 : DB01179 Podofilox Drug2 : DB04576 Fleroxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000143 Tubulin beta chain (-1) BE0001391 Tubulin alpha-4A chain (-1) --------------------------------------------------- Drug1 : DB01179 Podofilox Drug2 : DB09047 Finafloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000143 Tubulin beta chain (-1) BE0001391 Tubulin alpha-4A chain (-1) --------------------------------------------------- Drug1 : DB01182 Propafenone Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB01183 Naloxone Drug2 : DB09049 Naloxegol Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB01239 Chlorprothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB01267 Paliperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB01624 Zuclopenthixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB01185 Fluoxymesterone Drug2 : DB01420 Testosterone Propionate Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000123 Estrogen receptor (-1) --------------------------------------------------- Drug1 : DB01185 Fluoxymesterone Drug2 : DB01481 Delta1-dihydrotestosterone Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000123 Estrogen receptor (-1) --------------------------------------------------- Drug1 : DB01185 Fluoxymesterone Drug2 : DB01541 Boldenone Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000123 Estrogen receptor (-1) --------------------------------------------------- Drug1 : DB01185 Fluoxymesterone Drug2 : DB06710 Methyltestosterone Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000123 Estrogen receptor (-1) --------------------------------------------------- Drug1 : DB01185 Fluoxymesterone Drug2 : DB08804 Nandrolone decanoate Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000123 Estrogen receptor (-1) --------------------------------------------------- Drug1 : DB01189 Desflurane Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB01189 Desflurane Drug2 : DB08883 Perampanel Pharmacological target (-,-) : BE0000640 Glutamate receptor 1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB01191 Dexfenfluramine Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01191 Dexfenfluramine Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01191 Dexfenfluramine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01191 Dexfenfluramine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01191 Dexfenfluramine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01195 Flecainide Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB01196 Estramustine Drug2 : DB01357 Mestranol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) --------------------------------------------------- Drug1 : DB01196 Estramustine Drug2 : DB04573 Estriol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB01196 Estramustine Drug2 : DB04574 Estropipate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB01196 Estramustine Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01202 Levetiracetam Drug2 : DB08838 Agmatine Pharmacological target (-,-) : BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B Non-common off-target(s) (drug1) : BE0000993 Synaptic vesicle glycoprotein 2A (1) Non-common off-target(s) (drug2) : BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) BE0000342 Alpha-2C adrenergic receptor (1) BE0004661 Acetylcholine receptor subunit alpha (-1) BE0003580 Nischarin (1) BE0004768 Acid-sensing ion channel 3 (1) --------------------------------------------------- Drug1 : DB01204 Mitoxantrone Drug2 : DB04967 Lucanthone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0000971 DNA topoisomerase 1 (-1) BE0002414 DNA-(apurinic or apyrimidinic site) lyase (-1) --------------------------------------------------- Drug1 : DB01208 Sparfloxacin Drug2 : DB04967 Lucanthone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0000971 DNA topoisomerase 1 (-1) BE0002414 DNA-(apurinic or apyrimidinic site) lyase (-1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01351 Amobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01352 Aprobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01353 Butethal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01354 Heptabarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01355 Hexobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01440 Gamma Hydroxybutyric Acid Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01483 Barbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01221 Ketamine Drug2 : DB01520 Tenocyclidine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000632 Kappa-type opioid receptor (1) BE0000384 Substance-P receptor (-1) BE0004957 5-hydroxytryptamine receptor 2 (-1) BE0004958 5-hydroxytryptamine receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000454 Glutamate receptor ionotropic, NMDA 2C (-1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB01223 Aminophylline Drug2 : DB01412 Theobromine Pharmacological target (-,-) : BE0000013 Adenosine receptor A1 Non-common off-target(s) (drug1) : BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0000354 Adenosine receptor A3 (-1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000924 Adenosine receptor A2a (-1) --------------------------------------------------- Drug1 : DB01223 Aminophylline Drug2 : DB01427 Amrinone Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug1) : BE0000013 Adenosine receptor A1 (-1) BE0002366 Histone deacetylase 2 (1) BE0000354 Adenosine receptor A3 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) --------------------------------------------------- Drug1 : DB01223 Aminophylline Drug2 : DB04880 Enoximone Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug1) : BE0000013 Adenosine receptor A1 (-1) BE0002366 Histone deacetylase 2 (1) BE0000354 Adenosine receptor A3 (-1) --------------------------------------------------- Drug1 : DB01225 Enoxaparin Drug2 : DB06779 Dalteparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000216 Coagulation factor X (-1) Non-common off-target(s) (drug2) : BE0000967 Tissue factor pathway inhibitor (-1) BE0000163 Vascular endothelial growth factor A (-1) BE0001159 P-selectin (-1) --------------------------------------------------- Drug1 : DB01227 Levomethadyl Acetate Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01227 Levomethadyl Acetate Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB01227 Levomethadyl Acetate Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01227 Levomethadyl Acetate Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01228 Encainide Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB01231 Diphenidol Drug2 : DB01625 Isopropamide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB01231 Diphenidol Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB01267 Paliperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB01624 Zuclopenthixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB01236 Sevoflurane Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB01236 Sevoflurane Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB01236 Sevoflurane Drug2 : DB08883 Perampanel Pharmacological target (-,-) : BE0000640 Glutamate receptor 1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB01237 Bromodiphenhydramine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01238 Aripiprazole Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01238 Aripiprazole Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01239 Chlorprothixene Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01239 Chlorprothixene Drug2 : DB01608 Propericiazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01239 Chlorprothixene Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01239 Chlorprothixene Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01239 Chlorprothixene Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01241 Gemfibrozil Drug2 : DB01393 Bezafibrate Pharmacological target (+,+) : BE0000071 Peroxisome proliferator-activated receptor alpha Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) --------------------------------------------------- Drug1 : DB01242 Clomipramine Drug2 : DB01267 Paliperidone Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000814 Glutathione S-transferase P (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01242 Clomipramine Drug2 : DB04946 Iloperidone Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000814 Glutathione S-transferase P (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01242 Clomipramine Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000814 Glutathione S-transferase P (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01242 Clomipramine Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000814 Glutathione S-transferase P (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01246 Alimemazine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01247 Isocarboxazid Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01247 Isocarboxazid Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01247 Isocarboxazid Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01253 Ergonovine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01253 Ergonovine Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01253 Ergonovine Drug2 : DB06694 Xylometazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01255 Lisdexamfetamine Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01255 Lisdexamfetamine Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01255 Lisdexamfetamine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01255 Lisdexamfetamine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01267 Paliperidone Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01267 Paliperidone Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01269 Panitumumab Drug2 : DB08916 Afatinib Pharmacological target (-,-) : BE0000767 Epidermal growth factor receptor Non-common off-target(s) (drug2) : BE0000511 Receptor tyrosine-protein kinase erbB-2 (-1) BE0004772 Receptor tyrosine-protein kinase erbB-4 (-1) --------------------------------------------------- Drug1 : DB01274 Arformoterol Drug2 : DB01363 Ephedra Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01274 Arformoterol Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01283 Lumiracoxib Drug2 : DB08814 Triflusal Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug1) : BE0000262 Prostaglandin G/H synthase 2 (-1) Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) BE0001086 Nuclear factor NF-kappa-B p105 subunit (-1) --------------------------------------------------- Drug1 : DB01283 Lumiracoxib Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB01303 Oxtriphylline Drug2 : DB01412 Theobromine Pharmacological target (-,-) : BE0000013 Adenosine receptor A1 Pharmacological target (-,-) : BE0000924 Adenosine receptor A2a Non-common off-target(s) (drug1) : BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) --------------------------------------------------- Drug1 : DB01303 Oxtriphylline Drug2 : DB01427 Amrinone Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug1) : BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0002366 Histone deacetylase 2 (1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) --------------------------------------------------- Drug1 : DB01303 Oxtriphylline Drug2 : DB04880 Enoximone Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug1) : BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0002366 Histone deacetylase 2 (1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB01303 Oxtriphylline Drug2 : DB06751 Drotaverine Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) --------------------------------------------------- Drug1 : DB01320 Fosphenytoin Drug2 : DB01346 Quinidine barbiturate Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB01324 Polythiazide Drug2 : DB01325 Quinethazone Pharmacological target (-,-) : BE0000419 Solute carrier family 12 member 3 Non-common off-target(s) (drug2) : BE0000502 Solute carrier family 12 member 1 (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000281 Solute carrier family 12 member 2 (-1) --------------------------------------------------- Drug1 : DB01341 Dihydroquinidine barbiturate Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB01341 Dihydroquinidine barbiturate Drug2 : DB01351 Amobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01341 Dihydroquinidine barbiturate Drug2 : DB01352 Aprobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01341 Dihydroquinidine barbiturate Drug2 : DB01353 Butethal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01341 Dihydroquinidine barbiturate Drug2 : DB01354 Heptabarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01341 Dihydroquinidine barbiturate Drug2 : DB01355 Hexobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01341 Dihydroquinidine barbiturate Drug2 : DB01483 Barbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01341 Dihydroquinidine barbiturate Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01341 Dihydroquinidine barbiturate Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01341 Dihydroquinidine barbiturate Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01341 Dihydroquinidine barbiturate Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01341 Dihydroquinidine barbiturate Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) --------------------------------------------------- Drug1 : DB01341 Dihydroquinidine barbiturate Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01341 Dihydroquinidine barbiturate Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01341 Dihydroquinidine barbiturate Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01341 Dihydroquinidine barbiturate Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01346 Quinidine barbiturate Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB01346 Quinidine barbiturate Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01346 Quinidine barbiturate Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01346 Quinidine barbiturate Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) Non-common off-target(s) (drug2) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01346 Quinidine barbiturate Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) Non-common off-target(s) (drug2) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01346 Quinidine barbiturate Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) Non-common off-target(s) (drug2) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01346 Quinidine barbiturate Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01346 Quinidine barbiturate Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01346 Quinidine barbiturate Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) Non-common off-target(s) (drug2) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01346 Quinidine barbiturate Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) Non-common off-target(s) (drug2) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01351 Amobarbital Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01351 Amobarbital Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01351 Amobarbital Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01351 Amobarbital Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01351 Amobarbital Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01351 Amobarbital Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01351 Amobarbital Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01351 Amobarbital Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01352 Aprobarbital Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01352 Aprobarbital Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01352 Aprobarbital Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01352 Aprobarbital Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01352 Aprobarbital Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01352 Aprobarbital Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01352 Aprobarbital Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01352 Aprobarbital Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01353 Butethal Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01353 Butethal Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01353 Butethal Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01353 Butethal Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01353 Butethal Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01353 Butethal Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01353 Butethal Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01353 Butethal Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01354 Heptabarbital Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01354 Heptabarbital Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01354 Heptabarbital Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01354 Heptabarbital Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01354 Heptabarbital Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01354 Heptabarbital Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01354 Heptabarbital Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01354 Heptabarbital Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01355 Hexobarbital Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01355 Hexobarbital Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01355 Hexobarbital Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01355 Hexobarbital Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01355 Hexobarbital Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01355 Hexobarbital Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01355 Hexobarbital Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01355 Hexobarbital Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01357 Mestranol Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB01359 Penbutolol Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000797 5-hydroxytryptamine receptor 1B (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01359 Penbutolol Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000797 5-hydroxytryptamine receptor 1B (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01359 Penbutolol Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000797 5-hydroxytryptamine receptor 1B (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB01366 Procaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB01367 Rasagiline Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000246 Apoptosis regulator Bcl-2 (1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB01408 Bambuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB01463 Fencamfamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB04844 Tetrabenazine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB04948 Lofexidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB05039 Indacaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (+,+) : BE0000572 Alpha-2B adrenergic receptor Pharmacological target (+,+) : BE0000342 Alpha-2C adrenergic receptor Pharmacological target (+,+) : BE0001012 Beta-3 adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB06706 Isometheptene Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB08893 Mirabegron Pharmacological target (+,+) : BE0001012 Beta-3 adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01366 Procaterol Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01367 Rasagiline Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Non-common off-target(s) (drug1) : BE0000246 Apoptosis regulator Bcl-2 (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01367 Rasagiline Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Non-common off-target(s) (drug1) : BE0000246 Apoptosis regulator Bcl-2 (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01388 Mibefradil Drug2 : DB04841 Flunarizine Pharmacological target (-,-) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G Pharmacological target (-,-) : BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB01388 Mibefradil Drug2 : DB05246 Methsuximide Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB01392 Yohimbine Drug2 : DB01608 Propericiazine Pharmacological target (-,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01395 Drospirenone Drug2 : DB01431 Allylestrenol Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000132 Androgen receptor (-1) BE0000668 Mineralocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB01395 Drospirenone Drug2 : DB04839 Cyproterone acetate Pharmacological target (-,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB01395 Drospirenone Drug2 : DB06713 Norelgestromin Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000132 Androgen receptor (-1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB01395 Drospirenone Drug2 : DB08899 Enzalutamide Pharmacological target (-,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB01397 Magnesium salicylate Drug2 : DB08814 Triflusal Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug1) : BE0000262 Prostaglandin G/H synthase 2 (-1) Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) BE0001086 Nuclear factor NF-kappa-B p105 subunit (-1) --------------------------------------------------- Drug1 : DB01397 Magnesium salicylate Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB01398 Salicylate-sodium Drug2 : DB08814 Triflusal Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug1) : BE0000262 Prostaglandin G/H synthase 2 (-1) Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) BE0001086 Nuclear factor NF-kappa-B p105 subunit (-1) --------------------------------------------------- Drug1 : DB01398 Salicylate-sodium Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB01399 Salsalate Drug2 : DB08814 Triflusal Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug1) : BE0000262 Prostaglandin G/H synthase 2 (-1) Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) BE0001086 Nuclear factor NF-kappa-B p105 subunit (-1) --------------------------------------------------- Drug1 : DB01399 Salsalate Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB01406 Danazol Drug2 : DB01420 Testosterone Propionate Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB01406 Danazol Drug2 : DB01481 Delta1-dihydrotestosterone Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB01406 Danazol Drug2 : DB01541 Boldenone Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB01406 Danazol Drug2 : DB04573 Estriol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB01406 Danazol Drug2 : DB04574 Estropipate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB01406 Danazol Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB01406 Danazol Drug2 : DB06699 Degarelix Pharmacological target (-,-) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB01406 Danazol Drug2 : DB06710 Methyltestosterone Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB01406 Danazol Drug2 : DB06713 Norelgestromin Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB01406 Danazol Drug2 : DB08804 Nandrolone decanoate Pharmacological target (+,+) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB01408 Bambuterol Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01425 Alizapride Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01425 Alizapride Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01425 Alizapride Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01425 Alizapride Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01425 Alizapride Drug2 : DB01624 Zuclopenthixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01425 Alizapride Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB01433 Methadyl Acetate Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01433 Methadyl Acetate Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB01433 Methadyl Acetate Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01433 Methadyl Acetate Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01437 Glutethimide Drug2 : DB01483 Barbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01437 Glutethimide Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01437 Glutethimide Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01437 Glutethimide Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01437 Glutethimide Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01437 Glutethimide Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) --------------------------------------------------- Drug1 : DB01437 Glutethimide Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01437 Glutethimide Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01437 Glutethimide Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01437 Glutethimide Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01439 3-Methylthiofentanyl Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01439 3-Methylthiofentanyl Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01440 Gamma Hydroxybutyric Acid Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01440 Gamma Hydroxybutyric Acid Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01440 Gamma Hydroxybutyric Acid Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01440 Gamma Hydroxybutyric Acid Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) --------------------------------------------------- Drug1 : DB01440 Gamma Hydroxybutyric Acid Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01440 Gamma Hydroxybutyric Acid Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01440 Gamma Hydroxybutyric Acid Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01440 Gamma Hydroxybutyric Acid Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB01463 Fencamfamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB04844 Tetrabenazine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB06706 Isometheptene Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01454 3,4-Methylenedioxymethamphetamine Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01454 3,4-Methylenedioxymethamphetamine Drug2 : DB04844 Tetrabenazine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01454 3,4-Methylenedioxymethamphetamine Drug2 : DB06706 Isometheptene Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01463 Fencamfamine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01463 Fencamfamine Drug2 : DB01576 Dextroamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01463 Fencamfamine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01466 Ethylmorphine Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB01466 Ethylmorphine Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01466 Ethylmorphine Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01472 4-Methoxyamphetamine Drug2 : DB01579 Phendimetrazine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01472 4-Methoxyamphetamine Drug2 : DB04844 Tetrabenazine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01472 4-Methoxyamphetamine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01472 4-Methoxyamphetamine Drug2 : DB04948 Lofexidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01472 4-Methoxyamphetamine Drug2 : DB06694 Xylometazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01472 4-Methoxyamphetamine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01472 4-Methoxyamphetamine Drug2 : DB06706 Isometheptene Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01472 4-Methoxyamphetamine Drug2 : DB06707 Levonordefrin Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01472 4-Methoxyamphetamine Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB01472 4-Methoxyamphetamine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01483 Barbital Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01483 Barbital Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01483 Barbital Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01483 Barbital Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01483 Barbital Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01483 Barbital Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01483 Barbital Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01496 Barbituric acid derivative Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01496 Barbituric acid derivative Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01496 Barbituric acid derivative Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01496 Barbituric acid derivative Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01496 Barbituric acid derivative Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01496 Barbituric acid derivative Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01496 Barbituric acid derivative Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01497 Etorphine Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01520 Tenocyclidine Drug2 : DB03575 Phencyclidine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000454 Glutamate receptor ionotropic, NMDA 2C (-1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB01520 Tenocyclidine Drug2 : DB08954 Ifenprodil Pharmacological target (-,-) : BE0000417 Glutamate receptor ionotropic, NMDA 2B Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000454 Glutamate receptor ionotropic, NMDA 2C (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) --------------------------------------------------- Drug1 : DB01544 Flunitrazepam Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01544 Flunitrazepam Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01544 Flunitrazepam Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01544 Flunitrazepam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01544 Flunitrazepam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01544 Flunitrazepam Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01544 Flunitrazepam Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01558 Bromazepam Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB01558 Bromazepam Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01559 Clotiazepam Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB01559 Clotiazepam Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01567 Fludiazepam Drug2 : DB01587 Ketazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB01567 Fludiazepam Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01571 3-Methylfentanyl Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01576 Dextroamphetamine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01576 Dextroamphetamine Drug2 : DB06204 Tapentadol Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000770 Mu-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01576 Dextroamphetamine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB01576 Dextroamphetamine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB01577 Methamphetamine Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01577 Methamphetamine Drug2 : DB04844 Tetrabenazine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01577 Methamphetamine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01577 Methamphetamine Drug2 : DB04948 Lofexidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01577 Methamphetamine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01577 Methamphetamine Drug2 : DB06706 Isometheptene Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01577 Methamphetamine Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01577 Methamphetamine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01587 Ketazolam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01587 Ketazolam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01587 Ketazolam Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01587 Ketazolam Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01588 Prazepam Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01589 Quazepam Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) --------------------------------------------------- Drug1 : DB01594 Cinolazepam Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01595 Nitrazepam Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01600 Tiaprofenic acid Drug2 : DB08814 Triflusal Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug1) : BE0000262 Prostaglandin G/H synthase 2 (-1) Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) BE0001086 Nuclear factor NF-kappa-B p105 subunit (-1) --------------------------------------------------- Drug1 : DB01600 Tiaprofenic acid Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB01608 Propericiazine Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01608 Propericiazine Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01614 Acepromazine Drug2 : DB01616 Alverine Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01614 Acepromazine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01615 Aceprometazine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01616 Alverine Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01616 Alverine Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01619 Phenindamine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01620 Pheniramine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01621 Pipotiazine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01622 Thioproperazine Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB01622 Thioproperazine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01623 Thiothixene Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01623 Thiothixene Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01624 Zuclopenthixol Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01628 Etoricoxib Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB04552 Niflumic Acid Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB04576 Fleroxacin Drug2 : DB04967 Lucanthone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0000971 DNA topoisomerase 1 (-1) BE0002414 DNA-(apurinic or apyrimidinic site) lyase (-1) --------------------------------------------------- Drug1 : DB04743 Nimesulide Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB04837 Clofedanol Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB04841 Flunarizine Drug2 : DB05246 Methsuximide Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB04843 Mepenzolate Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB04890 Bepotastine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB04896 Milnacipran Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB04948 Lofexidine Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB04948 Lofexidine Drug2 : DB06694 Xylometazoline Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB04967 Lucanthone Drug2 : DB05630 Sodium stibogluconate Pharmacological target (-,-) : BE0000971 DNA topoisomerase 1 Non-common off-target(s) (drug1) : BE0000742 DNA topoisomerase 2-alpha (-1) BE0002414 DNA-(apurinic or apyrimidinic site) lyase (-1) --------------------------------------------------- Drug1 : DB04967 Lucanthone Drug2 : DB09047 Finafloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000971 DNA topoisomerase 1 (-1) BE0002414 DNA-(apurinic or apyrimidinic site) lyase (-1) --------------------------------------------------- Drug1 : DB05039 Indacaterol Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB05266 Ibudilast Drug2 : DB06751 Drotaverine Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) Non-common off-target(s) (drug2) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) --------------------------------------------------- Drug1 : DB06144 Sertindole Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB06144 Sertindole Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB06204 Tapentadol Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB06262 Droxidopa Drug2 : DB06706 Isometheptene Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB06262 Droxidopa Drug2 : DB06707 Levonordefrin Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB06262 Droxidopa Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB06262 Droxidopa Drug2 : DB08893 Mirabegron Pharmacological target (+,+) : BE0001012 Beta-3 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB06262 Droxidopa Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB06271 Sulodexide Drug2 : DB06779 Dalteparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000775 Heparin cofactor 2 (1) Non-common off-target(s) (drug2) : BE0000967 Tissue factor pathway inhibitor (-1) BE0000163 Vascular endothelial growth factor A (-1) BE0001159 P-selectin (-1) --------------------------------------------------- Drug1 : DB06589 Pazopanib Drug2 : DB06626 Axitinib Pharmacological target (-,-) : BE0000369 Vascular endothelial growth factor receptor 2 Pharmacological target (-,-) : BE0000029 Vascular endothelial growth factor receptor 1 Non-common off-target(s) (drug1) : BE0002133 Fibroblast growth factor receptor 3 (-1) BE0000205 Platelet-derived growth factor receptor beta (-1) BE0000852 Platelet-derived growth factor receptor alpha (-1) BE0000453 Mast/stem cell growth factor receptor Kit (-1) BE0000689 Fibroblast growth factor 1 (-1) BE0001341 Tyrosine-protein kinase ITK/TSK (-1) BE0004714 SH2B adapter protein 3 (-1) Non-common off-target(s) (drug2) : BE0000023 Vascular endothelial growth factor receptor 3 (-1) --------------------------------------------------- Drug1 : DB06589 Pazopanib Drug2 : DB08896 Regorafenib Pharmacological target (-,-) : BE0000205 Platelet-derived growth factor receptor beta Pharmacological target (-,-) : BE0000852 Platelet-derived growth factor receptor alpha Pharmacological target (-,-) : BE0000369 Vascular endothelial growth factor receptor 2 Pharmacological target (-,-) : BE0000453 Mast/stem cell growth factor receptor Kit Pharmacological target (-,-) : BE0000029 Vascular endothelial growth factor receptor 1 Non-common off-target(s) (drug1) : BE0002133 Fibroblast growth factor receptor 3 (-1) BE0000689 Fibroblast growth factor 1 (-1) BE0001341 Tyrosine-protein kinase ITK/TSK (-1) BE0004714 SH2B adapter protein 3 (-1) Non-common off-target(s) (drug2) : BE0000748 Fibroblast growth factor receptor 2 (-1) BE0002131 Fibroblast growth factor receptor 1 (-1) BE0000014 Tyrosine-protein kinase ABL1 (-1) BE0001039 High affinity nerve growth factor receptor (-1) BE0000634 Serine/threonine-protein kinase B-raf (-1) BE0000036 RAF proto-oncogene serine/threonine-protein kinase (-1) BE0000023 Vascular endothelial growth factor receptor 3 (-1) BE0002411 Proto-oncogene tyrosine-protein kinase receptor Ret (-1) BE0003379 Angiopoietin-1 receptor (-1) BE0000841 Ephrin type-A receptor 2 (-1) BE0003390 Mitogen-activated protein kinase 11 (-1) BE0004741 Discoidin domain-containing receptor 2 (-1) BE0004742 Tyrosine-protein kinase FRK (-1) --------------------------------------------------- Drug1 : DB06616 Bosutinib Drug2 : DB08896 Regorafenib Pharmacological target (-,-) : BE0000014 Tyrosine-protein kinase ABL1 Non-common off-target(s) (drug1) : BE0000838 Proto-oncogene tyrosine-protein kinase Src (-1) BE0001072 Cyclin-dependent kinase 2 (-1) BE0001424 Tyrosine-protein kinase HCK (-1) BE0000870 Dual specificity mitogen-activated protein kinase kinase 1 (-1) BE0004743 Breakpoint cluster region protein (-1) BE0004744 Dual specificity mitogen-activated protein kinase kinase 2 (-1) BE0004745 Mitogen-activated protein kinase kinase kinase 2 (-1) BE0004384 Calcium/calmodulin-dependent protein kinase type II subunit gamma (-1) Non-common off-target(s) (drug2) : BE0000748 Fibroblast growth factor receptor 2 (-1) BE0002131 Fibroblast growth factor receptor 1 (-1) BE0000205 Platelet-derived growth factor receptor beta (-1) BE0000852 Platelet-derived growth factor receptor alpha (-1) BE0001039 High affinity nerve growth factor receptor (-1) BE0000634 Serine/threonine-protein kinase B-raf (-1) BE0000036 RAF proto-oncogene serine/threonine-protein kinase (-1) BE0000023 Vascular endothelial growth factor receptor 3 (-1) BE0000369 Vascular endothelial growth factor receptor 2 (-1) BE0000453 Mast/stem cell growth factor receptor Kit (-1) BE0002411 Proto-oncogene tyrosine-protein kinase receptor Ret (-1) BE0000029 Vascular endothelial growth factor receptor 1 (-1) BE0003379 Angiopoietin-1 receptor (-1) BE0000841 Ephrin type-A receptor 2 (-1) BE0003390 Mitogen-activated protein kinase 11 (-1) BE0004741 Discoidin domain-containing receptor 2 (-1) BE0004742 Tyrosine-protein kinase FRK (-1) --------------------------------------------------- Drug1 : DB06626 Axitinib Drug2 : DB08896 Regorafenib Pharmacological target (-,-) : BE0000023 Vascular endothelial growth factor receptor 3 Pharmacological target (-,-) : BE0000369 Vascular endothelial growth factor receptor 2 Pharmacological target (-,-) : BE0000029 Vascular endothelial growth factor receptor 1 Non-common off-target(s) (drug2) : BE0000748 Fibroblast growth factor receptor 2 (-1) BE0002131 Fibroblast growth factor receptor 1 (-1) BE0000205 Platelet-derived growth factor receptor beta (-1) BE0000852 Platelet-derived growth factor receptor alpha (-1) BE0000014 Tyrosine-protein kinase ABL1 (-1) BE0001039 High affinity nerve growth factor receptor (-1) BE0000634 Serine/threonine-protein kinase B-raf (-1) BE0000036 RAF proto-oncogene serine/threonine-protein kinase (-1) BE0000453 Mast/stem cell growth factor receptor Kit (-1) BE0002411 Proto-oncogene tyrosine-protein kinase receptor Ret (-1) BE0003379 Angiopoietin-1 receptor (-1) BE0000841 Ephrin type-A receptor 2 (-1) BE0003390 Mitogen-activated protein kinase 11 (-1) BE0004741 Discoidin domain-containing receptor 2 (-1) BE0004742 Tyrosine-protein kinase FRK (-1) --------------------------------------------------- Drug1 : DB06626 Axitinib Drug2 : DB09078 Lenvatinib Pharmacological target (-,-) : BE0000023 Vascular endothelial growth factor receptor 3 Pharmacological target (-,-) : BE0000369 Vascular endothelial growth factor receptor 2 Pharmacological target (-,-) : BE0000029 Vascular endothelial growth factor receptor 1 Non-common off-target(s) (drug2) : BE0000748 Fibroblast growth factor receptor 2 (-1) BE0002131 Fibroblast growth factor receptor 1 (-1) BE0001203 Fibroblast growth factor receptor 4 (-1) BE0002133 Fibroblast growth factor receptor 3 (-1) BE0000453 Mast/stem cell growth factor receptor Kit (-1) BE0008625 Platelet derived growth factor receptor alpha (-1) BE0008626 RET (-1) --------------------------------------------------- Drug1 : DB06626 Axitinib Drug2 : DB09079 Nintedanib Pharmacological target (-,-) : BE0000023 Vascular endothelial growth factor receptor 3 Pharmacological target (-,-) : BE0000369 Vascular endothelial growth factor receptor 2 Pharmacological target (-,-) : BE0000029 Vascular endothelial growth factor receptor 1 Non-common off-target(s) (drug2) : BE0000748 Fibroblast growth factor receptor 2 (-1) BE0002131 Fibroblast growth factor receptor 1 (-1) BE0002133 Fibroblast growth factor receptor 3 (-1) BE0000147 Receptor-type tyrosine-protein kinase FLT3 (-1) BE0000838 Proto-oncogene tyrosine-protein kinase Src (-1) BE0000842 Tyrosine-protein kinase Lck (-1) BE0004315 Tyrosine-protein kinase Lyn (-1) BE0008625 Platelet derived growth factor receptor alpha (-1) BE0008628 Platelet derived growth factor receptor beta (-1) --------------------------------------------------- Drug1 : DB06691 Mepyramine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB06694 Xylometazoline Drug2 : DB06706 Isometheptene Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB06694 Xylometazoline Drug2 : DB06707 Levonordefrin Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB06700 Desvenlafaxine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB06725 Lornoxicam Drug2 : DB08814 Triflusal Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug1) : BE0000262 Prostaglandin G/H synthase 2 (-1) Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (1) BE0000631 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (-1) BE0001086 Nuclear factor NF-kappa-B p105 subunit (-1) --------------------------------------------------- Drug1 : DB06725 Lornoxicam Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB06779 Dalteparin Drug2 : DB06822 Tinzaparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000967 Tissue factor pathway inhibitor (-1) BE0000163 Vascular endothelial growth factor A (-1) BE0001159 P-selectin (-1) Non-common off-target(s) (drug2) : BE0000590 Integrin alpha-4 (-1) --------------------------------------------------- Drug1 : DB08799 Antazoline Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB08800 Chloropyramine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB08801 Dimetindene Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB08801 Dimetindene Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB08802 Isothipendyl Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB08810 Cinitapride Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB08815 Lurasidone Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB08838 Agmatine Drug2 : DB08954 Ifenprodil Pharmacological target (-,-) : BE0000365 Glutamate receptor ionotropic, NMDA 1 Non-common off-target(s) (drug1) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) BE0000342 Alpha-2C adrenergic receptor (1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0004661 Acetylcholine receptor subunit alpha (-1) BE0003580 Nischarin (1) BE0004768 Acid-sensing ion channel 3 (1) Non-common off-target(s) (drug2) : BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) --------------------------------------------------- Drug1 : DB08865 Crizotinib Drug2 : DB08875 Cabozantinib Pharmacological target (-,-) : BE0000915 Hepatocyte growth factor receptor Non-common off-target(s) (drug1) : BE0000359 ALK tyrosine kinase receptor (-1) Non-common off-target(s) (drug2) : BE0000369 Vascular endothelial growth factor receptor 2 (-1) BE0002411 Proto-oncogene tyrosine-protein kinase receptor Ret (-1) --------------------------------------------------- Drug1 : DB08875 Cabozantinib Drug2 : DB08896 Regorafenib Pharmacological target (-,-) : BE0000369 Vascular endothelial growth factor receptor 2 Pharmacological target (-,-) : BE0002411 Proto-oncogene tyrosine-protein kinase receptor Ret Non-common off-target(s) (drug1) : BE0000915 Hepatocyte growth factor receptor (-1) Non-common off-target(s) (drug2) : BE0000748 Fibroblast growth factor receptor 2 (-1) BE0002131 Fibroblast growth factor receptor 1 (-1) BE0000205 Platelet-derived growth factor receptor beta (-1) BE0000852 Platelet-derived growth factor receptor alpha (-1) BE0000014 Tyrosine-protein kinase ABL1 (-1) BE0001039 High affinity nerve growth factor receptor (-1) BE0000634 Serine/threonine-protein kinase B-raf (-1) BE0000036 RAF proto-oncogene serine/threonine-protein kinase (-1) BE0000023 Vascular endothelial growth factor receptor 3 (-1) BE0000453 Mast/stem cell growth factor receptor Kit (-1) BE0000029 Vascular endothelial growth factor receptor 1 (-1) BE0003379 Angiopoietin-1 receptor (-1) BE0000841 Ephrin type-A receptor 2 (-1) BE0003390 Mitogen-activated protein kinase 11 (-1) BE0004741 Discoidin domain-containing receptor 2 (-1) BE0004742 Tyrosine-protein kinase FRK (-1) --------------------------------------------------- Drug1 : DB08881 Vemurafenib Drug2 : DB08896 Regorafenib Pharmacological target (-,-) : BE0000634 Serine/threonine-protein kinase B-raf Non-common off-target(s) (drug2) : BE0000748 Fibroblast growth factor receptor 2 (-1) BE0002131 Fibroblast growth factor receptor 1 (-1) BE0000205 Platelet-derived growth factor receptor beta (-1) BE0000852 Platelet-derived growth factor receptor alpha (-1) BE0000014 Tyrosine-protein kinase ABL1 (-1) BE0001039 High affinity nerve growth factor receptor (-1) BE0000036 RAF proto-oncogene serine/threonine-protein kinase (-1) BE0000023 Vascular endothelial growth factor receptor 3 (-1) BE0000369 Vascular endothelial growth factor receptor 2 (-1) BE0000453 Mast/stem cell growth factor receptor Kit (-1) BE0002411 Proto-oncogene tyrosine-protein kinase receptor Ret (-1) BE0000029 Vascular endothelial growth factor receptor 1 (-1) BE0003379 Angiopoietin-1 receptor (-1) BE0000841 Ephrin type-A receptor 2 (-1) BE0003390 Mitogen-activated protein kinase 11 (-1) BE0004741 Discoidin domain-containing receptor 2 (-1) BE0004742 Tyrosine-protein kinase FRK (-1) --------------------------------------------------- Drug1 : DB08896 Regorafenib Drug2 : DB08912 Dabrafenib Pharmacological target (-,-) : BE0000634 Serine/threonine-protein kinase B-raf Pharmacological target (-,-) : BE0000036 RAF proto-oncogene serine/threonine-protein kinase Non-common off-target(s) (drug1) : BE0000748 Fibroblast growth factor receptor 2 (-1) BE0002131 Fibroblast growth factor receptor 1 (-1) BE0000205 Platelet-derived growth factor receptor beta (-1) BE0000852 Platelet-derived growth factor receptor alpha (-1) BE0000014 Tyrosine-protein kinase ABL1 (-1) BE0001039 High affinity nerve growth factor receptor (-1) BE0000023 Vascular endothelial growth factor receptor 3 (-1) BE0000369 Vascular endothelial growth factor receptor 2 (-1) BE0000453 Mast/stem cell growth factor receptor Kit (-1) BE0002411 Proto-oncogene tyrosine-protein kinase receptor Ret (-1) BE0000029 Vascular endothelial growth factor receptor 1 (-1) BE0003379 Angiopoietin-1 receptor (-1) BE0000841 Ephrin type-A receptor 2 (-1) BE0003390 Mitogen-activated protein kinase 11 (-1) BE0004741 Discoidin domain-containing receptor 2 (-1) BE0004742 Tyrosine-protein kinase FRK (-1) Non-common off-target(s) (drug2) : BE0004757 Serine/threonine-protein kinase SIK1 (-1) BE0004758 Serine/threonine-protein kinase Nek11 (-1) BE0004759 LIM domain kinase 1 (-1) --------------------------------------------------- Drug1 : DB08896 Regorafenib Drug2 : DB09078 Lenvatinib Pharmacological target (-,-) : BE0000748 Fibroblast growth factor receptor 2 Pharmacological target (-,-) : BE0002131 Fibroblast growth factor receptor 1 Pharmacological target (-,-) : BE0000023 Vascular endothelial growth factor receptor 3 Pharmacological target (-,-) : BE0000369 Vascular endothelial growth factor receptor 2 Pharmacological target (-,-) : BE0000453 Mast/stem cell growth factor receptor Kit Pharmacological target (-,-) : BE0000029 Vascular endothelial growth factor receptor 1 Non-common off-target(s) (drug1) : BE0000205 Platelet-derived growth factor receptor beta (-1) BE0000852 Platelet-derived growth factor receptor alpha (-1) BE0000014 Tyrosine-protein kinase ABL1 (-1) BE0001039 High affinity nerve growth factor receptor (-1) BE0000634 Serine/threonine-protein kinase B-raf (-1) BE0000036 RAF proto-oncogene serine/threonine-protein kinase (-1) BE0002411 Proto-oncogene tyrosine-protein kinase receptor Ret (-1) BE0003379 Angiopoietin-1 receptor (-1) BE0000841 Ephrin type-A receptor 2 (-1) BE0003390 Mitogen-activated protein kinase 11 (-1) BE0004741 Discoidin domain-containing receptor 2 (-1) BE0004742 Tyrosine-protein kinase FRK (-1) Non-common off-target(s) (drug2) : BE0001203 Fibroblast growth factor receptor 4 (-1) BE0002133 Fibroblast growth factor receptor 3 (-1) BE0008625 Platelet derived growth factor receptor alpha (-1) BE0008626 RET (-1) --------------------------------------------------- Drug1 : DB08896 Regorafenib Drug2 : DB09079 Nintedanib Pharmacological target (-,-) : BE0000748 Fibroblast growth factor receptor 2 Pharmacological target (-,-) : BE0002131 Fibroblast growth factor receptor 1 Pharmacological target (-,-) : BE0000023 Vascular endothelial growth factor receptor 3 Pharmacological target (-,-) : BE0000369 Vascular endothelial growth factor receptor 2 Pharmacological target (-,-) : BE0000029 Vascular endothelial growth factor receptor 1 Non-common off-target(s) (drug1) : BE0000205 Platelet-derived growth factor receptor beta (-1) BE0000852 Platelet-derived growth factor receptor alpha (-1) BE0000014 Tyrosine-protein kinase ABL1 (-1) BE0001039 High affinity nerve growth factor receptor (-1) BE0000634 Serine/threonine-protein kinase B-raf (-1) BE0000036 RAF proto-oncogene serine/threonine-protein kinase (-1) BE0000453 Mast/stem cell growth factor receptor Kit (-1) BE0002411 Proto-oncogene tyrosine-protein kinase receptor Ret (-1) BE0003379 Angiopoietin-1 receptor (-1) BE0000841 Ephrin type-A receptor 2 (-1) BE0003390 Mitogen-activated protein kinase 11 (-1) BE0004741 Discoidin domain-containing receptor 2 (-1) BE0004742 Tyrosine-protein kinase FRK (-1) Non-common off-target(s) (drug2) : BE0002133 Fibroblast growth factor receptor 3 (-1) BE0000147 Receptor-type tyrosine-protein kinase FLT3 (-1) BE0000838 Proto-oncogene tyrosine-protein kinase Src (-1) BE0000842 Tyrosine-protein kinase Lck (-1) BE0004315 Tyrosine-protein kinase Lyn (-1) BE0008625 Platelet derived growth factor receptor alpha (-1) BE0008628 Platelet derived growth factor receptor beta (-1) --------------------------------------------------- Drug1 : DB08904 Certolizumab pegol Drug2 : DB08910 Pomalidomide Pharmacological target (-,-) : BE0000704 Tumor necrosis factor Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) BE0004755 Protein cereblon (-1) --------------------------------------------------- Drug1 : DB08918 Levomilnacipran Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB08936 Chlorcyclizine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) ---------------------------------------------------