Drug pairs with common pharmacological targets that do not change the overall side effect on the 2 drugs Drug1 : DB00247 Methysergide Drug2 : DB00477 Chlorpromazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB00652 Pentazocine Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB00652 Pentazocine Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB00652 Pentazocine Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB00611 Butorphanol Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00521 Carteolol Pharmacological target (+,+) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB00521 Carteolol Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00490 Buspirone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB00521 Carteolol Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01622 Thioproperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB00652 Pentazocine Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) BE0004899 Kappa-type opioid receptor 2b (1) Non-common off-target(s) (drug2) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) BE0004899 Kappa-type opioid receptor 2b (1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB00598 Labetalol Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB00668 Epinephrine Pharmacological target (+,+) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB00866 Alprenolol Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB01064 Isoprenaline Pharmacological target (+,+) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB01210 Levobunolol Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB01214 Metipranolol Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB01363 Ephedra Pharmacological target (+,+) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB06262 Droxidopa Pharmacological target (+,+) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00574 Fenfluramine Drug2 : DB01149 Nefazodone Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000393 5-hydroxytryptamine receptor 2B (1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00589 Lisuride Drug2 : DB09014 Captodiame Pharmacological target (+,+) : BE0000581 D(3) dopamine receptor Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00611 Butorphanol Drug2 : DB00956 Hydrocodone Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB00704 Naltrexone Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (-1) BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB00836 Loperamide Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB01183 Naloxone Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (-1) BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB06698 Betahistine Pharmacological target (+,+) : BE0000442 Histamine H1 receptor Pharmacological target (+,-) : BE0000968 Histamine H3 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) --------------------------------------------------- Drug1 : DB00704 Naltrexone Drug2 : DB01209 Dezocine Pharmacological target (-,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (-1) BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00753 Isoflurane Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) Non-common off-target(s) (drug2) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00836 Loperamide Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB06706 Isometheptene Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01028 Methoxyflurane Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) Non-common off-target(s) (drug2) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01149 Nefazodone Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01183 Naloxone Drug2 : DB01209 Dezocine Pharmacological target (-,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (-1) BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB01185 Fluoxymesterone Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000132 Androgen receptor Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000557 Progesterone receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB01209 Dezocine Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01209 Dezocine Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB01209 Dezocine Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01209 Dezocine Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01239 Chlorprothixene Drug2 : DB09014 Captodiame Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB01267 Paliperidone Drug2 : DB09014 Captodiame Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB01395 Drospirenone Drug2 : DB01406 Danazol Pharmacological target (+,+) : BE0000557 Progesterone receptor Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000668 Mineralocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB01472 4-Methoxyamphetamine Drug2 : DB01576 Dextroamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (+,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01614 Acepromazine Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01621 Pipotiazine Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01622 Thioproperazine Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) ---------------------------------------------------