Drug pairs with common pharmacological targets that worsen the overall side effect on the 2 drugs Drug1 : DB00007 Leuprolide Drug2 : DB00050 Cetrorelix Pharmacological target (+,-) : BE0000203 Gonadotropin-releasing hormone receptor --------------------------------------------------- Drug1 : DB00007 Leuprolide Drug2 : DB00106 Abarelix Pharmacological target (+,-) : BE0000203 Gonadotropin-releasing hormone receptor --------------------------------------------------- Drug1 : DB00007 Leuprolide Drug2 : DB01406 Danazol Pharmacological target (+,-) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00007 Leuprolide Drug2 : DB06699 Degarelix Pharmacological target (+,-) : BE0000203 Gonadotropin-releasing hormone receptor --------------------------------------------------- Drug1 : DB00009 Alteplase Drug2 : DB00302 Tranexamic Acid Pharmacological target (+,-) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00009 Alteplase Drug2 : DB00513 Aminocaproic Acid Pharmacological target (+,-) : BE0000211 Plasminogen Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) --------------------------------------------------- Drug1 : DB00013 Urokinase Drug2 : DB00302 Tranexamic Acid Pharmacological target (+,-) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00013 Urokinase Drug2 : DB00513 Aminocaproic Acid Pharmacological target (+,-) : BE0000211 Plasminogen Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) --------------------------------------------------- Drug1 : DB00014 Goserelin Drug2 : DB00050 Cetrorelix Pharmacological target (+,-) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug1) : BE0000134 Lutropin-choriogonadotropic hormone receptor (1) --------------------------------------------------- Drug1 : DB00014 Goserelin Drug2 : DB00106 Abarelix Pharmacological target (+,-) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug1) : BE0000134 Lutropin-choriogonadotropic hormone receptor (1) --------------------------------------------------- Drug1 : DB00014 Goserelin Drug2 : DB01406 Danazol Pharmacological target (+,-) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug1) : BE0000134 Lutropin-choriogonadotropic hormone receptor (1) Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00014 Goserelin Drug2 : DB06699 Degarelix Pharmacological target (+,-) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug1) : BE0000134 Lutropin-choriogonadotropic hormone receptor (1) --------------------------------------------------- Drug1 : DB00015 Reteplase Drug2 : DB00302 Tranexamic Acid Pharmacological target (+,-) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00015 Reteplase Drug2 : DB00513 Aminocaproic Acid Pharmacological target (+,-) : BE0000211 Plasminogen Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) --------------------------------------------------- Drug1 : DB00025 Antihemophilic Factor Drug2 : DB00569 Fondaparinux sodium Pharmacological target (+,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug1) : BE0002117 Phytanoyl-CoA dioxygenase, peroxisomal (-1) Non-common off-target(s) (drug2) : BE0000280 Antithrombin-III (1) --------------------------------------------------- Drug1 : DB00025 Antihemophilic Factor Drug2 : DB01109 Heparin Pharmacological target (+,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug1) : BE0002117 Phytanoyl-CoA dioxygenase, peroxisomal (-1) Non-common off-target(s) (drug2) : BE0000280 Antithrombin-III (1) BE0001159 P-selectin (-1) --------------------------------------------------- Drug1 : DB00025 Antihemophilic Factor Drug2 : DB01225 Enoxaparin Pharmacological target (+,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug1) : BE0002117 Phytanoyl-CoA dioxygenase, peroxisomal (-1) Non-common off-target(s) (drug2) : BE0000280 Antithrombin-III (1) --------------------------------------------------- Drug1 : DB00025 Antihemophilic Factor Drug2 : DB06228 Rivaroxaban Pharmacological target (+,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug1) : BE0002117 Phytanoyl-CoA dioxygenase, peroxisomal (-1) --------------------------------------------------- Drug1 : DB00025 Antihemophilic Factor Drug2 : DB06605 Apixaban Pharmacological target (+,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug1) : BE0002117 Phytanoyl-CoA dioxygenase, peroxisomal (-1) --------------------------------------------------- Drug1 : DB00025 Antihemophilic Factor Drug2 : DB09075 Edoxaban Pharmacological target (+,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug1) : BE0002117 Phytanoyl-CoA dioxygenase, peroxisomal (-1) --------------------------------------------------- Drug1 : DB00029 Anistreplase Drug2 : DB00302 Tranexamic Acid Pharmacological target (+,-) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00029 Anistreplase Drug2 : DB00513 Aminocaproic Acid Pharmacological target (+,-) : BE0000211 Plasminogen Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) --------------------------------------------------- Drug1 : DB00031 Tenecteplase Drug2 : DB00302 Tranexamic Acid Pharmacological target (+,-) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00031 Tenecteplase Drug2 : DB00513 Aminocaproic Acid Pharmacological target (+,-) : BE0000211 Plasminogen Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) --------------------------------------------------- Drug1 : DB00035 Desmopressin Drug2 : DB00872 Conivaptan Pharmacological target (+,-) : BE0000293 Vasopressin V2 receptor Non-common off-target(s) (drug2) : BE0000165 Vasopressin V1a receptor (-1) --------------------------------------------------- Drug1 : DB00035 Desmopressin Drug2 : DB06212 Tolvaptan Pharmacological target (+,-) : BE0000293 Vasopressin V2 receptor Non-common off-target(s) (drug2) : BE0000165 Vasopressin V1a receptor (-1) --------------------------------------------------- Drug1 : DB00050 Cetrorelix Drug2 : DB00644 Gonadorelin Pharmacological target (+,-) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug2) : BE0000472 Putative gonadotropin-releasing hormone II receptor (1) --------------------------------------------------- Drug1 : DB00050 Cetrorelix Drug2 : DB00666 Nafarelin Pharmacological target (+,-) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug2) : BE0000472 Putative gonadotropin-releasing hormone II receptor (1) --------------------------------------------------- Drug1 : DB00066 Follitropin beta Drug2 : DB04786 Suramin Pharmacological target (+,-) : BE0000387 Follicle-stimulating hormone receptor Non-common off-target(s) (drug2) : BE0000048 Prothrombin (-1) BE0000739 Ryanodine receptor 1 (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0003362 NAD-dependent protein deacylase sirtuin-5, mitochondrial (-1) BE0002401 P2Y purinoceptor 2 (-1) --------------------------------------------------- Drug1 : DB00067 Vasopressin Drug2 : DB00872 Conivaptan Pharmacological target (+,-) : BE0000293 Vasopressin V2 receptor Non-common off-target(s) (drug2) : BE0000165 Vasopressin V1a receptor (-1) --------------------------------------------------- Drug1 : DB00067 Vasopressin Drug2 : DB06212 Tolvaptan Pharmacological target (+,-) : BE0000293 Vasopressin V2 receptor Non-common off-target(s) (drug2) : BE0000165 Vasopressin V1a receptor (-1) --------------------------------------------------- Drug1 : DB00086 Streptokinase Drug2 : DB00302 Tranexamic Acid Pharmacological target (+,-) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00086 Streptokinase Drug2 : DB00513 Aminocaproic Acid Pharmacological target (+,-) : BE0000211 Plasminogen Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) --------------------------------------------------- Drug1 : DB00093 Felypressin Drug2 : DB00872 Conivaptan Pharmacological target (+,-) : BE0000165 Vasopressin V1a receptor Non-common off-target(s) (drug2) : BE0000293 Vasopressin V2 receptor (-1) --------------------------------------------------- Drug1 : DB00094 Urofollitropin Drug2 : DB04786 Suramin Pharmacological target (+,-) : BE0000387 Follicle-stimulating hormone receptor Non-common off-target(s) (drug2) : BE0000048 Prothrombin (-1) BE0000739 Ryanodine receptor 1 (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0003362 NAD-dependent protein deacylase sirtuin-5, mitochondrial (-1) BE0002401 P2Y purinoceptor 2 (-1) --------------------------------------------------- Drug1 : DB00100 Coagulation Factor IX Drug2 : DB00569 Fondaparinux sodium Pharmacological target (+,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug2) : BE0000280 Antithrombin-III (1) --------------------------------------------------- Drug1 : DB00100 Coagulation Factor IX Drug2 : DB01109 Heparin Pharmacological target (+,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug2) : BE0000280 Antithrombin-III (1) BE0001159 P-selectin (-1) --------------------------------------------------- Drug1 : DB00100 Coagulation Factor IX Drug2 : DB01225 Enoxaparin Pharmacological target (+,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug2) : BE0000280 Antithrombin-III (1) --------------------------------------------------- Drug1 : DB00100 Coagulation Factor IX Drug2 : DB06228 Rivaroxaban Pharmacological target (+,-) : BE0000216 Coagulation factor X --------------------------------------------------- Drug1 : DB00100 Coagulation Factor IX Drug2 : DB06605 Apixaban Pharmacological target (+,-) : BE0000216 Coagulation factor X --------------------------------------------------- Drug1 : DB00100 Coagulation Factor IX Drug2 : DB09075 Edoxaban Pharmacological target (+,-) : BE0000216 Coagulation factor X --------------------------------------------------- Drug1 : DB00106 Abarelix Drug2 : DB00644 Gonadorelin Pharmacological target (+,-) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug2) : BE0000472 Putative gonadotropin-releasing hormone II receptor (1) --------------------------------------------------- Drug1 : DB00106 Abarelix Drug2 : DB00666 Nafarelin Pharmacological target (+,-) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug2) : BE0000472 Putative gonadotropin-releasing hormone II receptor (1) --------------------------------------------------- Drug1 : DB00136 Calcitriol Drug2 : DB00146 Calcidiol Pharmacological target (+,-) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00136 Calcitriol Drug2 : DB00153 Ergocalciferol Pharmacological target (+,-) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00136 Calcitriol Drug2 : DB00169 Cholecalciferol Pharmacological target (+,-) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00136 Calcitriol Drug2 : DB00910 Paricalcitol Pharmacological target (+,-) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00136 Calcitriol Drug2 : DB01070 Dihydrotachysterol Pharmacological target (+,-) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00136 Calcitriol Drug2 : DB01436 Alfacalcidol Pharmacological target (+,-) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00179 Masoprocol Drug2 : DB00586 Diclofenac Pharmacological target (+,-) : BE0000248 Arachidonate 5-lipoxygenase Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00219 Oxyphenonium Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00245 Benzatropine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00332 Ipratropium bromide Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00354 Buclizine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00383 Oxyphencyclimine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00387 Procyclidine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00392 Ethopropazine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00505 Tridihexethyl Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00508 Triflupromazine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00517 Anisotropine Methylbromide Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00572 Atropine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00670 Pirenzepine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00725 Homatropine Methylbromide Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00729 Diphemanil Methylsulfate Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00767 Benzquinamide Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00771 Clidinium Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00782 Propantheline Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00785 Cryptenamine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00804 Dicyclomine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00810 Biperiden Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00942 Cycrimine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB00979 Cyclopentolate Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB01036 Tolterodine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB01062 Oxybutynin Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB01142 Doxepin Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB01148 Flavoxate Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB01231 Diphenidol Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB01625 Isopropamide Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB04843 Mepenzolate Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB08897 Aclidinium Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB00221 Isoetarine Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB00368 Norepinephrine Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB00521 Carteolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB00668 Epinephrine Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB00841 Dobutamine Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB00960 Pindolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB01064 Isoprenaline Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB01102 Arbutamine Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB01193 Acebutolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB01363 Ephedra Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB08807 Bopindolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00226 Guanadrel Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00226 Guanadrel Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00201 Caffeine Drug2 : DB00640 Adenosine Pharmacological target (+,-) : BE0000013 Adenosine receptor A1 Pharmacological target (+,-) : BE0000924 Adenosine receptor A2a Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0004922 Cyclic nucleotide phosphodiesterase (-1) Non-common off-target(s) (drug2) : BE0000241 Adenosine receptor A2b (1) BE0000354 Adenosine receptor A3 (1) --------------------------------------------------- Drug1 : DB00201 Caffeine Drug2 : DB06213 Regadenoson Pharmacological target (+,-) : BE0000924 Adenosine receptor A2a Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0004922 Cyclic nucleotide phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00202 Succinylcholine Drug2 : DB00219 Oxyphenonium Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (1) BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00202 Succinylcholine Drug2 : DB00245 Benzatropine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (1) BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00202 Succinylcholine Drug2 : DB00333 Methadone Pharmacological target (+,-) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000770 Mu-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00202 Succinylcholine Drug2 : DB00354 Buclizine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (1) BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00202 Succinylcholine Drug2 : DB00670 Pirenzepine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (1) BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00202 Succinylcholine Drug2 : DB00771 Clidinium Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (1) BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00202 Succinylcholine Drug2 : DB00782 Propantheline Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (1) BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00202 Succinylcholine Drug2 : DB00810 Biperiden Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (1) BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00202 Succinylcholine Drug2 : DB00942 Cycrimine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (1) BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00202 Succinylcholine Drug2 : DB00979 Cyclopentolate Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (1) BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00202 Succinylcholine Drug2 : DB01090 Pentolinium Pharmacological target (+,-) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) BE0003584 Neuronal acetylcholine receptor subunit beta-4 (-1) --------------------------------------------------- Drug1 : DB00202 Succinylcholine Drug2 : DB01116 Trimethaphan Pharmacological target (+,-) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00206 Reserpine Drug2 : DB00865 Benzphetamine Pharmacological target (+,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00206 Reserpine Drug2 : DB01576 Dextroamphetamine Pharmacological target (+,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00208 Ticlopidine Drug2 : DB00374 Treprostinil Pharmacological target (+,-) : BE0000110 P2Y purinoceptor 12 Non-common off-target(s) (drug2) : BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000475 Prostacyclin receptor (1) --------------------------------------------------- Drug1 : DB00208 Ticlopidine Drug2 : DB01240 Epoprostenol Pharmacological target (+,-) : BE0000110 P2Y purinoceptor 12 Non-common off-target(s) (drug2) : BE0000475 Prostacyclin receptor (1) BE0000117 Prostacyclin synthase (1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB00450 Droperidol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB00477 Chlorpromazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB00679 Thioridazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB00692 Phentolamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB00699 Nicergoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB00797 Tolazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB00831 Trifluoperazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB00875 Flupentixol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB01622 Thioproperazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00214 Torasemide Drug2 : DB00534 Chlormerodrin Pharmacological target (+,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000152 Succinate-semialdehyde dehydrogenase, mitochondrial (-1) --------------------------------------------------- Drug1 : DB00217 Bethanidine Drug2 : DB00350 Minoxidil Pharmacological target (+,-) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 Non-common off-target(s) (drug1) : BE0004872 Beta adrenergic receptor (-1) BE0004864 Alpha-2 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (1) --------------------------------------------------- Drug1 : DB00217 Bethanidine Drug2 : DB01049 Ergoloid mesylate Pharmacological target (+,-) : BE0004864 Alpha-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0004872 Beta adrenergic receptor (-1) BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0001042 Solute carrier organic anion transporter family member 2B1 (-1) BE0004862 Serotonin Receptors (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00411 Carbachol Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00221 Isoetarine Drug2 : DB00335 Atenolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00221 Isoetarine Drug2 : DB01118 Amiodarone Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB00221 Isoetarine Drug2 : DB01297 Practolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00222 Glimepiride Drug2 : DB00350 Minoxidil Pharmacological target (+,-) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 Non-common off-target(s) (drug1) : BE0000207 ATP-binding cassette sub-family C member 8 (1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (1) --------------------------------------------------- Drug1 : DB00222 Glimepiride Drug2 : DB00672 Chlorpropamide Pharmacological target (+,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug1) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) --------------------------------------------------- Drug1 : DB00222 Glimepiride Drug2 : DB00731 Nateglinide Pharmacological target (+,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug1) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00222 Glimepiride Drug2 : DB00912 Repaglinide Pharmacological target (+,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug1) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00222 Glimepiride Drug2 : DB00922 Levosimendan Pharmacological target (+,-) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 Non-common off-target(s) (drug1) : BE0000207 ATP-binding cassette sub-family C member 8 (1) BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) Non-common off-target(s) (drug2) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0001024 Troponin C, slow skeletal and cardiac muscles (1) BE0002441 ATP-sensitive inward rectifier potassium channel 8 (1) --------------------------------------------------- Drug1 : DB00222 Glimepiride Drug2 : DB01067 Glipizide Pharmacological target (+,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug1) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00222 Glimepiride Drug2 : DB01119 Diazoxide Pharmacological target (+,-) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 Non-common off-target(s) (drug1) : BE0000207 ATP-binding cassette sub-family C member 8 (1) BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) --------------------------------------------------- Drug1 : DB00222 Glimepiride Drug2 : DB01251 Gliquidone Pharmacological target (+,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug1) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) Non-common off-target(s) (drug2) : BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) --------------------------------------------------- Drug1 : DB00222 Glimepiride Drug2 : DB01252 Mitiglinide Pharmacological target (+,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug1) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB00234 Reboxetine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB00285 Venlafaxine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB00321 Amitriptyline Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB00344 Protriptyline Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB00458 Imipramine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB00476 Duloxetine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB00540 Nortriptyline Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB00579 Mazindol Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB00726 Trimipramine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB00830 Phenmetrazine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB00907 Cocaine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB00934 Maprotiline Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB00937 Diethylpropion Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB01105 Sibutramine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB01142 Doxepin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB01149 Nefazodone Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB01151 Desipramine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB01156 Bupropion Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB01173 Orphenadrine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB01363 Ephedra Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB01454 3,4-Methylenedioxymethamphetamine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB01576 Dextroamphetamine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB01577 Methamphetamine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB01579 Phendimetrazine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB04896 Milnacipran Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB06204 Tapentadol Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000770 Mu-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB06700 Desvenlafaxine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB06701 Dexmethylphenidate Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB08918 Levomilnacipran Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00228 Enflurane Drug2 : DB01373 Calcium Pharmacological target (+,-) : BE0000218 Calcium-transporting ATPase type 2C member 1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0004857 Glycine receptor (alpha-1/beta) (1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) Non-common off-target(s) (drug2) : BE0001024 Troponin C, slow skeletal and cardiac muscles (1) BE0003566 Troponin C, skeletal muscle (1) BE0004593 Spectrin beta chain, non-erythrocytic 1 (1) --------------------------------------------------- Drug1 : DB00228 Enflurane Drug2 : DB06637 Dalfampridine Pharmacological target (+,-) : BE0000781 Potassium voltage-gated channel subfamily A member 1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0004857 Glycine receptor (alpha-1/beta) (1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) Non-common off-target(s) (drug2) : BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0004502 Potassium voltage-gated channel subfamily A member 4 (-1) BE0004715 Potassium voltage-gated channel subfamily A member 2 (-1) BE0004716 Potassium voltage-gated channel subfamily A member 3 (-1) BE0004717 Potassium voltage-gated channel subfamily A member 5 (-1) BE0004718 Potassium voltage-gated channel subfamily A member 6 (-1) BE0004719 Potassium voltage-gated channel subfamily A member 7 (-1) BE0004720 Potassium voltage-gated channel subfamily A member 10 (-1) BE0004721 Potassium voltage-gated channel subfamily B member 1 (-1) BE0004722 Potassium voltage-gated channel subfamily B member 2 (-1) BE0004723 Potassium voltage-gated channel subfamily C member 1 (-1) BE0004724 Potassium voltage-gated channel subfamily C member 2 (-1) BE0004725 Potassium voltage-gated channel subfamily C member 3 (-1) BE0004726 Potassium voltage-gated channel subfamily D member 1 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00431 Lindane Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00466 Picrotoxin Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00474 Methohexital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,-) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00232 Methyclothiazide Drug2 : DB00534 Chlormerodrin Pharmacological target (+,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) Non-common off-target(s) (drug2) : BE0000152 Succinate-semialdehyde dehydrogenase, mitochondrial (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB00466 Picrotoxin Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB00474 Methohexital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00411 Carbachol Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00246 Ziprasidone Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00246 Ziprasidone Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB00574 Fenfluramine Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (+,-) : BE0000393 5-hydroxytryptamine receptor 2B Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB00604 Cisapride Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB00866 Alprenolol Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB01359 Penbutolol Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000797 5-hydroxytryptamine receptor 1B (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB01616 Alverine Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00248 Cabergoline Drug2 : DB00433 Prochlorperazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0004889 D(1) dopamine receptor (1) BE0004916 D(2S) dopamine receptor (1) BE0004915 D(2L) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00248 Cabergoline Drug2 : DB00450 Droperidol Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0004889 D(1) dopamine receptor (1) BE0004916 D(2S) dopamine receptor (1) BE0004915 D(2L) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00248 Cabergoline Drug2 : DB00831 Trifluoperazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0004889 D(1) dopamine receptor (1) BE0004916 D(2S) dopamine receptor (1) BE0004915 D(2L) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00248 Cabergoline Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0004889 D(1) dopamine receptor (1) BE0004916 D(2S) dopamine receptor (1) BE0004915 D(2L) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00248 Cabergoline Drug2 : DB01425 Alizapride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0004889 D(1) dopamine receptor (1) BE0004916 D(2S) dopamine receptor (1) BE0004915 D(2L) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00248 Cabergoline Drug2 : DB09018 Bromopride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0004889 D(1) dopamine receptor (1) BE0004916 D(2S) dopamine receptor (1) BE0004915 D(2L) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00255 Diethylstilbestrol Drug2 : DB00947 Fulvestrant Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0002088 Estrogen-related receptor gamma (1) BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00255 Diethylstilbestrol Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0002088 Estrogen-related receptor gamma (1) BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00268 Ropinirole Drug2 : DB00433 Prochlorperazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00268 Ropinirole Drug2 : DB00450 Droperidol Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00268 Ropinirole Drug2 : DB00831 Trifluoperazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00268 Ropinirole Drug2 : DB01100 Pimozide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00268 Ropinirole Drug2 : DB01184 Domperidone Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00268 Ropinirole Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00268 Ropinirole Drug2 : DB01425 Alizapride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00268 Ropinirole Drug2 : DB09018 Bromopride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB00947 Fulvestrant Pharmacological target (+,-) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00272 Betazole Drug2 : DB00501 Cimetidine Pharmacological target (+,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00272 Betazole Drug2 : DB00585 Nizatidine Pharmacological target (+,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00272 Betazole Drug2 : DB00751 Epinastine Pharmacological target (+,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00272 Betazole Drug2 : DB00863 Ranitidine Pharmacological target (+,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00272 Betazole Drug2 : DB00927 Famotidine Pharmacological target (+,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00272 Betazole Drug2 : DB00940 Methantheline Pharmacological target (+,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00272 Betazole Drug2 : DB01142 Doxepin Pharmacological target (+,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00272 Betazole Drug2 : DB08805 Metiamide Pharmacological target (+,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00272 Betazole Drug2 : DB08806 Roxatidine acetate Pharmacological target (+,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB00466 Picrotoxin Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) --------------------------------------------------- Drug1 : DB00273 Topiramate Drug2 : DB00474 Methohexital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000346 Glutamate receptor ionotropic, kainate 1 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00277 Theophylline Drug2 : DB00640 Adenosine Pharmacological target (+,-) : BE0000013 Adenosine receptor A1 Pharmacological target (+,-) : BE0000924 Adenosine receptor A2a Pharmacological target (+,-) : BE0000241 Adenosine receptor A2b Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) Non-common off-target(s) (drug2) : BE0000354 Adenosine receptor A3 (1) --------------------------------------------------- Drug1 : DB00277 Theophylline Drug2 : DB02546 Vorinostat Pharmacological target (+,-) : BE0002366 Histone deacetylase 2 Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0000241 Adenosine receptor A2b (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) Non-common off-target(s) (drug2) : BE0002365 Histone deacetylase 1 (-1) BE0002367 Histone deacetylase 3 (-1) BE0002368 Histone deacetylase 6 (-1) --------------------------------------------------- Drug1 : DB00277 Theophylline Drug2 : DB06213 Regadenoson Pharmacological target (+,-) : BE0000924 Adenosine receptor A2a Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0000241 Adenosine receptor A2b (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00667 Histamine Phosphate Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB00947 Fulvestrant Pharmacological target (+,-) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00466 Picrotoxin Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00474 Methohexital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB01392 Yohimbine Pharmacological target (+,-) : BE0000572 Alpha-2B adrenergic receptor Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) Non-common off-target(s) (drug2) : BE0000794 Glucocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB00947 Fulvestrant Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB00704 Naltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB00844 Nalbuphine Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB01183 Naloxone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB00368 Norepinephrine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (+,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB00397 Phenylpropanolamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB00449 Dipivefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB00610 Metaraminol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB00696 Ergotamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (+,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB00865 Benzphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB00964 Apraclonidine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB01253 Ergonovine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (+,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) Non-common off-target(s) (drug2) : BE0000794 Glucocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB00947 Fulvestrant Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB00466 Picrotoxin Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB00474 Methohexital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00308 Ibutilide Drug2 : DB00393 Nimodipine Pharmacological target (+,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (+,-) : BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0003721 Aryl hydrocarbon receptor (1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00308 Ibutilide Drug2 : DB00568 Cinnarizine Pharmacological target (+,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00308 Ibutilide Drug2 : DB01388 Mibefradil Pharmacological target (+,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (+,-) : BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00310 Chlorthalidone Drug2 : DB00534 Chlormerodrin Pharmacological target (+,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000152 Succinate-semialdehyde dehydrogenase, mitochondrial (-1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB00466 Picrotoxin Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB00474 Methohexital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00315 Zolmitriptan Drug2 : DB00477 Chlorpromazine Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00315 Zolmitriptan Drug2 : DB00866 Alprenolol Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00315 Zolmitriptan Drug2 : DB01142 Doxepin Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00315 Zolmitriptan Drug2 : DB01149 Nefazodone Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00315 Zolmitriptan Drug2 : DB01614 Acepromazine Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00315 Zolmitriptan Drug2 : DB01616 Alverine Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) --------------------------------------------------- Drug1 : DB00315 Zolmitriptan Drug2 : DB01621 Pipotiazine Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00315 Zolmitriptan Drug2 : DB01622 Thioproperazine Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB00704 Naltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB00844 Nalbuphine Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB01183 Naloxone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB00604 Cisapride Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB00704 Naltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB00844 Nalbuphine Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB01183 Naloxone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00411 Carbachol Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB01019 Bethanechol Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB00652 Pentazocine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000420 Delta-type opioid receptor (1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB00704 Naltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB00844 Nalbuphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB01183 Naloxone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB01548 Diprenorphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB06800 Methylnaltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000420 Delta-type opioid receptor (1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000420 Delta-type opioid receptor (1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00334 Olanzapine Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004889 D(1) dopamine receptor (-1) BE0000112 Histamine H2 receptor (-1) BE0000146 Histamine H4 receptor (-1) BE0004688 5-hydroxytryptamine receptor 5A (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB00368 Norepinephrine Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB00521 Carteolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB00668 Epinephrine Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB00841 Dobutamine Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB00960 Pindolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB01064 Isoprenaline Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB01102 Arbutamine Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB01193 Acebutolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB01363 Ephedra Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB08807 Bopindolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00337 Pimecrolimus Drug2 : DB00877 Sirolimus Pharmacological target (+,-) : BE0002386 Serine/threonine-protein kinase mTOR Non-common off-target(s) (drug1) : BE0000695 Peptidyl-prolyl cis-trans isomerase FKBP1A (1) --------------------------------------------------- Drug1 : DB00337 Pimecrolimus Drug2 : DB01590 Everolimus Pharmacological target (+,-) : BE0002386 Serine/threonine-protein kinase mTOR Non-common off-target(s) (drug1) : BE0000695 Peptidyl-prolyl cis-trans isomerase FKBP1A (1) --------------------------------------------------- Drug1 : DB00337 Pimecrolimus Drug2 : DB06287 Temsirolimus Pharmacological target (+,-) : BE0002386 Serine/threonine-protein kinase mTOR Non-common off-target(s) (drug1) : BE0000695 Peptidyl-prolyl cis-trans isomerase FKBP1A (1) --------------------------------------------------- Drug1 : DB00340 Metixene Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00667 Histamine Phosphate Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00667 Histamine Phosphate Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB00368 Norepinephrine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (+,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB00397 Phenylpropanolamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB00449 Dipivefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB00610 Metaraminol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB00696 Ergotamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (+,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB00865 Benzphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB00964 Apraclonidine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB01253 Ergonovine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (+,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00350 Minoxidil Drug2 : DB00414 Acetohexamide Pharmacological target (+,-) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (1) --------------------------------------------------- Drug1 : DB00350 Minoxidil Drug2 : DB00839 Tolazamide Pharmacological target (+,-) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (1) --------------------------------------------------- Drug1 : DB00350 Minoxidil Drug2 : DB08838 Agmatine Pharmacological target (+,-) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (1) Non-common off-target(s) (drug2) : BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000342 Alpha-2C adrenergic receptor (1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0004661 Acetylcholine receptor subunit alpha (-1) BE0003580 Nischarin (1) BE0004768 Acid-sensing ion channel 3 (1) --------------------------------------------------- Drug1 : DB00353 Methylergometrine Drug2 : DB00800 Fenoldopam Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00353 Methylergometrine Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000756 D(2) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00353 Methylergometrine Drug2 : DB01235 L-DOPA Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00411 Carbachol Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00667 Histamine Phosphate Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00358 Mefloquine Drug2 : DB00893 Iron Dextran Pharmacological target (+,-) : BE0000130 Hemoglobin subunit alpha Non-common off-target(s) (drug1) : BE0000924 Adenosine receptor A2a (-1) Non-common off-target(s) (drug2) : BE0000629 Hemoglobin subunit beta (1) --------------------------------------------------- Drug1 : DB00363 Clozapine Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000146 Histamine H4 receptor (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00363 Clozapine Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000146 Histamine H4 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00364 Sucralfate Drug2 : DB00686 Pentosan Polysulfate Pharmacological target (+,-) : BE0001015 Fibroblast growth factor 2 Non-common off-target(s) (drug1) : BE0000538 Fibrinogen alpha chain (-1) BE0004791 Pepsin (-1) BE0000953 Pro-epidermal growth factor (1) BE0002091 Fibrinogen beta chain (-1) BE0002092 Fibrinogen gamma chain (-1) Non-common off-target(s) (drug2) : BE0000689 Fibroblast growth factor 1 (-1) BE0000326 Fibroblast growth factor 4 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00667 Histamine Phosphate Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00370 Mirtazapine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00373 Timolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00450 Droperidol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00457 Prazosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (+,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00477 Chlorpromazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00489 Sotalol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00590 Doxazosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (+,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00598 Labetalol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00679 Thioridazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00692 Phentolamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00699 Nicergoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00831 Trifluoperazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00866 Alprenolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB00875 Flupentixol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB01118 Amiodarone Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB01162 Terazosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (+,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB01210 Levobunolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB01214 Metipranolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB01297 Practolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB01392 Yohimbine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (+,-) : BE0000572 Alpha-2B adrenergic receptor Pharmacological target (+,-) : BE0000342 Alpha-2C adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00368 Norepinephrine Drug2 : DB01622 Thioproperazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00397 Phenylpropanolamine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00449 Dipivefrin Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00484 Brimonidine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00575 Clonidine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00604 Cisapride Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (+,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00629 Guanabenz Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00633 Dexmedetomidine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00668 Epinephrine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00865 Benzphetamine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00935 Oxymetazoline Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB00964 Apraclonidine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB01018 Guanfacine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB01363 Ephedra Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB01577 Methamphetamine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB04948 Lofexidine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB06694 Xylometazoline Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00370 Mirtazapine Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00466 Picrotoxin Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00474 Methohexital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB00449 Dipivefrin Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB00668 Epinephrine Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB00816 Orciprenaline Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB00867 Ritodrine Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB00871 Terbutaline Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB00938 Salmeterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB00983 Formoterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB01064 Isoprenaline Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB01274 Arformoterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB01363 Ephedra Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB01366 Procaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB01408 Bambuterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB05039 Indacaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB09080 Olodaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00374 Treprostinil Drug2 : DB00758 Clopidogrel Pharmacological target (+,-) : BE0000110 P2Y purinoceptor 12 Non-common off-target(s) (drug1) : BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000475 Prostacyclin receptor (1) --------------------------------------------------- Drug1 : DB00374 Treprostinil Drug2 : DB06209 Prasugrel Pharmacological target (+,-) : BE0000110 P2Y purinoceptor 12 Non-common off-target(s) (drug1) : BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000475 Prostacyclin receptor (1) --------------------------------------------------- Drug1 : DB00374 Treprostinil Drug2 : DB08816 Ticagrelor Pharmacological target (+,-) : BE0000110 P2Y purinoceptor 12 Non-common off-target(s) (drug1) : BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000475 Prostacyclin receptor (1) --------------------------------------------------- Drug1 : DB00376 Trihexyphenidyl Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00377 Palonosetron Drug2 : DB00604 Cisapride Pharmacological target (+,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00378 Dydrogesterone Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000557 Progesterone receptor Non-common off-target(s) (drug2) : BE0000794 Glucocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00382 Tacrine Drug2 : DB00449 Dipivefrin Pharmacological target (+,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00382 Tacrine Drug2 : DB00733 Pralidoxime Pharmacological target (+,-) : BE0000426 Acetylcholinesterase Pharmacological target (+,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00411 Carbachol Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB01019 Bethanechol Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00386 Alseroxylon Drug2 : DB00865 Benzphetamine Pharmacological target (+,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00386 Alseroxylon Drug2 : DB01576 Dextroamphetamine Pharmacological target (+,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB00411 Carbachol Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB01019 Bethanechol Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB00687 Fludrocortisone Pharmacological target (+,-) : BE0000668 Mineralocorticoid receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000794 Glucocorticoid receptor (1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000123 Estrogen receptor (1) BE0000668 Mineralocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000794 Glucocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB00947 Fulvestrant Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB01134 Desoxycorticosterone Pivalate Pharmacological target (+,-) : BE0000668 Mineralocorticoid receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB00450 Droperidol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB00457 Prazosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB00590 Doxazosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB00692 Phentolamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB00699 Nicergoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB00706 Tamsulosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB00831 Trifluoperazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB00925 Phenoxybenzamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB01162 Terazosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB01392 Yohimbine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB06207 Silodosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB00466 Picrotoxin Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) Non-common off-target(s) (drug2) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB00474 Methohexital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00667 Histamine Phosphate Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB00413 Pramipexole Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB00604 Cisapride Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00416 Metocurine Iodide Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00424 Hyoscyamine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00462 Methylscopolamine bromide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00505 Tridihexethyl Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00508 Triflupromazine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00517 Anisotropine Methylbromide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00565 Cisatracurium Besylate Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00572 Atropine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00657 Mecamylamine Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00670 Pirenzepine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00725 Homatropine Methylbromide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00728 Rocuronium Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) Non-common off-target(s) (drug2) : BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00732 Atracurium Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00767 Benzquinamide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00771 Clidinium Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00782 Propantheline Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00785 Cryptenamine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00810 Biperiden Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00942 Cycrimine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00979 Cyclopentolate Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB00986 Glycopyrrolate Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB01036 Tolterodine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB01062 Oxybutynin Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB01142 Doxepin Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB01148 Flavoxate Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB01199 Tubocurarine Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB01226 Mivacurium Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB01231 Diphenidol Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB01339 Vecuronium Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB04843 Mepenzolate Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB08801 Dimetindene Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB08897 Aclidinium Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB00433 Prochlorperazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB00450 Droperidol Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB00477 Chlorpromazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB00490 Buspirone Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB00508 Triflupromazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB00623 Fluphenazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB00679 Thioridazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB00831 Trifluoperazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB00850 Perphenazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB00875 Flupentixol Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB00933 Mesoridazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB01038 Carphenazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB01063 Acetophenazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB01100 Pimozide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB01184 Domperidone Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB01239 Chlorprothixene Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB01425 Alizapride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB01614 Acepromazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB01618 Molindone Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB01621 Pipotiazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB01622 Thioproperazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB01623 Thiothixene Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB04842 Fluspirilene Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB06144 Sertindole Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB08815 Lurasidone Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB09018 Bromopride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00416 Metocurine Iodide Drug2 : DB01245 Decamethonium Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB00466 Picrotoxin Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB00474 Methohexital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB01205 Flumazenil Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00420 Promazine Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00421 Spironolactone Drug2 : DB01134 Desoxycorticosterone Pivalate Pharmacological target (+,-) : BE0000668 Mineralocorticoid receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (-1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (-1) BE0003542 Cytochrome P450 11B2, mitochondrial (-1) BE0004886 17alpha-hydroxylase (-1) BE0004885 17,20-desmolase (-1) --------------------------------------------------- Drug1 : DB00422 Methylphenidate Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00424 Hyoscyamine Drug2 : DB01019 Bethanechol Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00424 Hyoscyamine Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00425 Zolpidem Drug2 : DB00466 Picrotoxin Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) Non-common off-target(s) (drug2) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) --------------------------------------------------- Drug1 : DB00425 Zolpidem Drug2 : DB00474 Methohexital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) --------------------------------------------------- Drug1 : DB00425 Zolpidem Drug2 : DB01205 Flumazenil Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00667 Histamine Phosphate Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00431 Lindane Drug2 : DB00546 Adinazolam Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00431 Lindane Drug2 : DB00683 Midazolam Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00431 Lindane Drug2 : DB00690 Flurazepam Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00431 Lindane Drug2 : DB00801 Halazepam Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00431 Lindane Drug2 : DB00829 Diazepam Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00431 Lindane Drug2 : DB00842 Oxazepam Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00431 Lindane Drug2 : DB00897 Triazolam Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00431 Lindane Drug2 : DB01215 Estazolam Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00431 Lindane Drug2 : DB01440 Gamma Hydroxybutyric Acid Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0004841 Gamma-hydroxybutyrate (GHB) receptor (1) --------------------------------------------------- Drug1 : DB00431 Lindane Drug2 : DB01558 Bromazepam Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00431 Lindane Drug2 : DB01559 Clotiazepam Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00431 Lindane Drug2 : DB01567 Fludiazepam Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00431 Lindane Drug2 : DB01587 Ketazolam Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) --------------------------------------------------- Drug1 : DB00431 Lindane Drug2 : DB01588 Prazepam Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00431 Lindane Drug2 : DB01589 Quazepam Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00431 Lindane Drug2 : DB01594 Cinolazepam Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00431 Lindane Drug2 : DB01595 Nitrazepam Pharmacological target (+,-) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Non-common off-target(s) (drug1) : BE0000433 Glycine receptor subunit alpha-1 (-1) BE0000055 Glycine receptor subunit beta (-1) BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB00589 Lisuride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB00714 Apomorphine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0000666 Neuron-specific vesicular protein calcyon (1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01186 Pergolide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01200 Bromocriptine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01235 L-DOPA Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB05271 Rotigotine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000572 Alpha-2B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00574 Fenfluramine Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000393 5-hydroxytryptamine receptor 2B (1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00589 Lisuride Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00604 Cisapride Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB00667 Histamine Phosphate Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00436 Bendroflumethiazide Drug2 : DB01003 Cromoglicic acid Pharmacological target (+,-) : BE0000553 Calcium-activated potassium channel subunit alpha-1 Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000419 Solute carrier family 12 member 3 (-1) Non-common off-target(s) (drug2) : BE0001191 Protein S100-P (-1) --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00450 Droperidol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00457 Prazosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00477 Chlorpromazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00489 Sotalol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00521 Carteolol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00545 Pyridostigmine Pharmacological target (+,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00590 Doxazosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00598 Labetalol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00677 Isoflurophate Pharmacological target (+,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00679 Thioridazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00692 Phentolamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00699 Nicergoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00706 Tamsulosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00772 Malathion Pharmacological target (+,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00831 Trifluoperazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00866 Alprenolol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00875 Flupentixol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00925 Phenoxybenzamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00941 Hexafluronium Pharmacological target (+,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00989 Rivastigmine Pharmacological target (+,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01010 Edrophonium Pharmacological target (+,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01057 Echothiophate Pharmacological target (+,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01162 Terazosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01210 Levobunolol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01214 Metipranolol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01392 Yohimbine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01608 Propericiazine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB01622 Thioproperazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB06207 Silodosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00589 Lisuride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00610 Metaraminol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00668 Epinephrine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00714 Apomorphine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0000666 Neuron-specific vesicular protein calcyon (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00723 Methoxamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00865 Benzphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00935 Oxymetazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00964 Apraclonidine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB01235 L-DOPA Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB01253 Ergonovine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB01579 Phendimetrazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB05271 Rotigotine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000572 Alpha-2B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB06694 Xylometazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00667 Histamine Phosphate Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00457 Prazosin Drug2 : DB00610 Metaraminol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00457 Prazosin Drug2 : DB00696 Ergotamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (+,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00457 Prazosin Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00457 Prazosin Drug2 : DB00865 Benzphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00457 Prazosin Drug2 : DB00964 Apraclonidine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00457 Prazosin Drug2 : DB01253 Ergonovine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00457 Prazosin Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00457 Prazosin Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (+,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00457 Prazosin Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00457 Prazosin Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00457 Prazosin Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00462 Methylscopolamine bromide Drug2 : DB01019 Bethanechol Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00462 Methylscopolamine bromide Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB00466 Picrotoxin Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB00474 Methohexital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB00546 Adinazolam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB00599 Thiopental Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB00683 Midazolam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB00690 Flurazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB00753 Isoflurane Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB00794 Primidone Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB00801 Halazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB00829 Diazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB00837 Progabide Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB00842 Oxazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB00849 Methylphenobarbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB00897 Triazolam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB00962 Zaleplon Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01028 Methoxyflurane Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01107 Methyprylon Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01154 Thiamylal Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01174 Phenobarbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01198 Zopiclone Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01215 Estazolam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01236 Sevoflurane Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01351 Amobarbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01352 Aprobarbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01353 Butethal Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01354 Heptabarbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01355 Hexobarbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01437 Glutethimide Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01483 Barbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01558 Bromazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01559 Clotiazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01567 Fludiazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01587 Ketazolam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01588 Prazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01589 Quazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01594 Cinolazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB01595 Nitrazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00470 Dronabinol Drug2 : DB06155 Rimonabant Pharmacological target (+,-) : BE0000061 Cannabinoid receptor 1 Non-common off-target(s) (drug1) : BE0000095 Cannabinoid receptor 2 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB00546 Adinazolam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB00599 Thiopental Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB00683 Midazolam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB00690 Flurazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB00753 Isoflurane Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB00794 Primidone Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB00801 Halazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB00829 Diazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB00837 Progabide Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB00842 Oxazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB00849 Methylphenobarbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB00897 Triazolam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB00898 Ethanol Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000745 Glycine receptor subunit alpha-2 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB00962 Zaleplon Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01028 Methoxyflurane Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01107 Methyprylon Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01154 Thiamylal Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01174 Phenobarbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01198 Zopiclone Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01215 Estazolam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01236 Sevoflurane Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01351 Amobarbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01352 Aprobarbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01353 Butethal Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01354 Heptabarbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01355 Hexobarbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01437 Glutethimide Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01483 Barbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01558 Bromazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01559 Clotiazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01567 Fludiazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01587 Ketazolam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01588 Prazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01589 Quazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01594 Cinolazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00474 Methohexital Drug2 : DB01595 Nitrazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00476 Duloxetine Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00476 Duloxetine Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00604 Cisapride Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00610 Metaraminol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00667 Histamine Phosphate Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00668 Epinephrine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00669 Sumatriptan Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00800 Fenoldopam Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00865 Benzphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00952 Naratriptan Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00964 Apraclonidine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01235 L-DOPA Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01253 Ergonovine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00481 Raloxifene Drug2 : DB00947 Fulvestrant Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00481 Raloxifene Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB00733 Pralidoxime Pharmacological target (+,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB01019 Bethanechol Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) --------------------------------------------------- Drug1 : DB00484 Brimonidine Drug2 : DB00692 Phentolamine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00484 Brimonidine Drug2 : DB01392 Yohimbine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (+,-) : BE0000572 Alpha-2B adrenergic receptor Pharmacological target (+,-) : BE0000342 Alpha-2C adrenergic receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00484 Brimonidine Drug2 : DB01608 Propericiazine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00486 Nabilone Drug2 : DB06155 Rimonabant Pharmacological target (+,-) : BE0000061 Cannabinoid receptor 1 Non-common off-target(s) (drug1) : BE0000095 Cannabinoid receptor 2 (1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB00668 Epinephrine Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB00816 Orciprenaline Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB00867 Ritodrine Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB00871 Terbutaline Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB00938 Salmeterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB00983 Formoterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB01064 Isoprenaline Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB01274 Arformoterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB01363 Ephedra Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB01366 Procaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB01408 Bambuterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB05039 Indacaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB09080 Olodaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB00866 Alprenolol Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01149 Nefazodone Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01235 L-DOPA Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01359 Penbutolol Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000797 5-hydroxytryptamine receptor 1B (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01616 Alverine Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00496 Darifenacin Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB00704 Naltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0004899 Kappa-type opioid receptor 2b (1) Non-common off-target(s) (drug2) : BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB00844 Nalbuphine Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0004899 Kappa-type opioid receptor 2b (1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB01183 Naloxone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0004899 Kappa-type opioid receptor 2b (1) Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0004899 Kappa-type opioid receptor 2b (1) --------------------------------------------------- Drug1 : DB00499 Flutamide Drug2 : DB00621 Oxandrolone Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00499 Flutamide Drug2 : DB00624 Testosterone Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00499 Flutamide Drug2 : DB00858 Drostanolone Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00499 Flutamide Drug2 : DB00984 Nandrolone phenpropionate Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00499 Flutamide Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000123 Estrogen receptor (-1) --------------------------------------------------- Drug1 : DB00499 Flutamide Drug2 : DB01406 Danazol Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00499 Flutamide Drug2 : DB01420 Testosterone Propionate Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00499 Flutamide Drug2 : DB01481 Delta1-dihydrotestosterone Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00499 Flutamide Drug2 : DB01541 Boldenone Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00499 Flutamide Drug2 : DB06710 Methyltestosterone Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00499 Flutamide Drug2 : DB08804 Nandrolone decanoate Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00501 Cimetidine Drug2 : DB00667 Histamine Phosphate Pharmacological target (+,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00502 Haloperidol Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB00611 Butorphanol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB00652 Pentazocine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB00704 Naltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB00844 Nalbuphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB01183 Naloxone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB01548 Diprenorphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB06274 Alvimopan Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB06800 Methylnaltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB01019 Bethanechol Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB00574 Fenfluramine Pharmacological target (+,-) : BE0000393 5-hydroxytryptamine receptor 2B Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB00800 Fenoldopam Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB01019 Bethanechol Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB01235 L-DOPA Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB01019 Bethanechol Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB00816 Orciprenaline Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB00867 Ritodrine Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB00871 Terbutaline Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB00938 Salmeterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB00983 Formoterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB01118 Amiodarone Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB01274 Arformoterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB01297 Practolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB01366 Procaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB01408 Bambuterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB05039 Indacaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB09080 Olodaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00534 Chlormerodrin Drug2 : DB00695 Furosemide Pharmacological target (+,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug1) : BE0000152 Succinate-semialdehyde dehydrogenase, mitochondrial (-1) --------------------------------------------------- Drug1 : DB00534 Chlormerodrin Drug2 : DB00774 Hydroflumethiazide Pharmacological target (+,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug1) : BE0000152 Succinate-semialdehyde dehydrogenase, mitochondrial (-1) Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) --------------------------------------------------- Drug1 : DB00534 Chlormerodrin Drug2 : DB00887 Bumetanide Pharmacological target (+,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug1) : BE0000152 Succinate-semialdehyde dehydrogenase, mitochondrial (-1) Non-common off-target(s) (drug2) : BE0000281 Solute carrier family 12 member 2 (-1) BE0000047 Solute carrier family 12 member 5 (-1) BE0000601 Solute carrier family 12 member 4 (-1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00534 Chlormerodrin Drug2 : DB00903 Ethacrynic acid Pharmacological target (+,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug1) : BE0000152 Succinate-semialdehyde dehydrogenase, mitochondrial (-1) Non-common off-target(s) (drug2) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 (-1) --------------------------------------------------- Drug1 : DB00534 Chlormerodrin Drug2 : DB01021 Trichlormethiazide Pharmacological target (+,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug1) : BE0000152 Succinate-semialdehyde dehydrogenase, mitochondrial (-1) Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 (-1) --------------------------------------------------- Drug1 : DB00534 Chlormerodrin Drug2 : DB01325 Quinethazone Pharmacological target (+,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug1) : BE0000152 Succinate-semialdehyde dehydrogenase, mitochondrial (-1) Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000419 Solute carrier family 12 member 3 (-1) BE0000281 Solute carrier family 12 member 2 (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB00604 Cisapride Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00545 Pyridostigmine Drug2 : DB00733 Pralidoxime Pharmacological target (+,-) : BE0000426 Acetylcholinesterase Pharmacological target (+,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01205 Flumazenil Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,-) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00667 Histamine Phosphate Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00565 Cisatracurium Besylate Drug2 : DB01245 Decamethonium Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB00667 Histamine Phosphate Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) Non-common off-target(s) (drug2) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB01019 Bethanechol Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00574 Fenfluramine Drug2 : DB01142 Doxepin Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (+,-) : BE0000393 5-hydroxytryptamine receptor 2B Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00574 Fenfluramine Drug2 : DB01239 Chlorprothixene Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (+,-) : BE0000393 5-hydroxytryptamine receptor 2B Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00574 Fenfluramine Drug2 : DB01242 Clomipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (+,-) : BE0000393 5-hydroxytryptamine receptor 2B Non-common off-target(s) (drug2) : BE0000814 Glutathione S-transferase P (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00574 Fenfluramine Drug2 : DB01267 Paliperidone Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000393 5-hydroxytryptamine receptor 2B (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00574 Fenfluramine Drug2 : DB06144 Sertindole Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000393 5-hydroxytryptamine receptor 2B (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00574 Fenfluramine Drug2 : DB06594 Agomelatine Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000393 5-hydroxytryptamine receptor 2B (1) Non-common off-target(s) (drug2) : BE0000515 Melatonin receptor type 1A (1) BE0000327 Melatonin receptor type 1B (1) --------------------------------------------------- Drug1 : DB00574 Fenfluramine Drug2 : DB09014 Captodiame Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000393 5-hydroxytryptamine receptor 2B (1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00575 Clonidine Drug2 : DB01392 Yohimbine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (+,-) : BE0000572 Alpha-2B adrenergic receptor Pharmacological target (+,-) : BE0000342 Alpha-2C adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00585 Nizatidine Drug2 : DB00667 Histamine Phosphate Pharmacological target (+,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00586 Diclofenac Drug2 : DB00744 Zileuton Pharmacological target (+,-) : BE0000248 Arachidonate 5-lipoxygenase Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0001640 Phospholipase A2, membrane associated (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) BE0000353 Acid-sensing ion channel 1 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00589 Lisuride Drug2 : DB00831 Trifluoperazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00589 Lisuride Drug2 : DB00924 Cyclobenzaprine Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00589 Lisuride Drug2 : DB00933 Mesoridazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00589 Lisuride Drug2 : DB01100 Pimozide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00589 Lisuride Drug2 : DB01151 Desipramine Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00589 Lisuride Drug2 : DB01184 Domperidone Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00589 Lisuride Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00589 Lisuride Drug2 : DB01425 Alizapride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00589 Lisuride Drug2 : DB06144 Sertindole Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00589 Lisuride Drug2 : DB06594 Agomelatine Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000515 Melatonin receptor type 1A (1) BE0000327 Melatonin receptor type 1B (1) --------------------------------------------------- Drug1 : DB00589 Lisuride Drug2 : DB09016 Butriptyline Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00589 Lisuride Drug2 : DB09018 Bromopride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00590 Doxazosin Drug2 : DB00610 Metaraminol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00590 Doxazosin Drug2 : DB00696 Ergotamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (+,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00590 Doxazosin Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00590 Doxazosin Drug2 : DB00865 Benzphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00590 Doxazosin Drug2 : DB00964 Apraclonidine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00590 Doxazosin Drug2 : DB01253 Ergonovine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00590 Doxazosin Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00590 Doxazosin Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (+,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00590 Doxazosin Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00590 Doxazosin Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00590 Doxazosin Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB00668 Epinephrine Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB00816 Orciprenaline Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB00867 Ritodrine Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB00871 Terbutaline Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB00938 Salmeterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB00983 Formoterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB01064 Isoprenaline Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB01274 Arformoterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB01363 Ephedra Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB01366 Procaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB01408 Bambuterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB05039 Indacaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB09080 Olodaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB01205 Flumazenil Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00603 Medroxyprogesterone Acetate Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) Non-common off-target(s) (drug2) : BE0000794 Glucocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00603 Medroxyprogesterone Acetate Drug2 : DB00947 Fulvestrant Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00603 Medroxyprogesterone Acetate Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB00656 Trazodone Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB00721 Procaine Pharmacological target (+,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB00734 Risperidone Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB00757 Dolasetron Pharmacological target (+,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB00805 Minaprine Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB00875 Flupentixol Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB00889 Granisetron Pharmacological target (+,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB00924 Cyclobenzaprine Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB00933 Mesoridazine Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB00969 Alosetron Pharmacological target (+,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB01142 Doxepin Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB01149 Nefazodone Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB01151 Desipramine Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB01199 Tubocurarine Pharmacological target (+,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB01224 Quetiapine Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB01239 Chlorprothixene Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB01242 Clomipramine Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000814 Glutathione S-transferase P (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB01267 Paliperidone Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB01614 Acepromazine Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB01621 Pipotiazine Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB01622 Thioproperazine Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB01623 Thiothixene Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB04946 Iloperidone Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB06216 Asenapine Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000172 Beta-1 adrenergic receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) BE0004688 5-hydroxytryptamine receptor 5A (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB08815 Lurasidone Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00604 Cisapride Drug2 : DB09016 Butriptyline Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB00679 Thioridazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB00692 Phentolamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB00699 Nicergoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB00706 Tamsulosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB00797 Tolazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB00831 Trifluoperazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB00875 Flupentixol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB00925 Phenoxybenzamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB01136 Carvedilol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000173 NADH dehydrogenase [ubiquinone] 1 subunit C2 (-1) BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0001114 Vascular cell adhesion protein 1 (-1) BE0001074 E-selectin (-1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB01162 Terazosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB01622 Thioproperazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB06207 Silodosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00611 Butorphanol Drug2 : DB00647 Dextropropoxyphene Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor --------------------------------------------------- Drug1 : DB00611 Butorphanol Drug2 : DB00704 Naltrexone Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00611 Butorphanol Drug2 : DB00802 Alfentanil Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00611 Butorphanol Drug2 : DB00913 Anileridine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00611 Butorphanol Drug2 : DB01183 Naloxone Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB00611 Butorphanol Drug2 : DB01209 Dezocine Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00611 Butorphanol Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00611 Butorphanol Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00611 Butorphanol Drug2 : DB01466 Ethylmorphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00611 Butorphanol Drug2 : DB06204 Tapentadol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00621 Oxandrolone Drug2 : DB00665 Nilutamide Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00621 Oxandrolone Drug2 : DB01128 Bicalutamide Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00621 Oxandrolone Drug2 : DB01395 Drospirenone Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00621 Oxandrolone Drug2 : DB04839 Cyproterone acetate Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00621 Oxandrolone Drug2 : DB08899 Enzalutamide Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB00800 Fenoldopam Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB01235 L-DOPA Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00624 Testosterone Drug2 : DB00665 Nilutamide Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00624 Testosterone Drug2 : DB01128 Bicalutamide Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00624 Testosterone Drug2 : DB01395 Drospirenone Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00624 Testosterone Drug2 : DB04839 Cyproterone acetate Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00624 Testosterone Drug2 : DB08899 Enzalutamide Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB00692 Phentolamine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB00925 Phenoxybenzamine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB01392 Yohimbine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB01608 Propericiazine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00633 Dexmedetomidine Drug2 : DB00692 Phentolamine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00633 Dexmedetomidine Drug2 : DB00925 Phenoxybenzamine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00633 Dexmedetomidine Drug2 : DB01392 Yohimbine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00633 Dexmedetomidine Drug2 : DB01608 Propericiazine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB00667 Histamine Phosphate Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00640 Adenosine Drug2 : DB00651 Dyphylline Pharmacological target (+,-) : BE0000013 Adenosine receptor A1 Pharmacological target (+,-) : BE0000924 Adenosine receptor A2a Non-common off-target(s) (drug1) : BE0000241 Adenosine receptor A2b (1) BE0000354 Adenosine receptor A3 (1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) --------------------------------------------------- Drug1 : DB00640 Adenosine Drug2 : DB00806 Pentoxifylline Pharmacological target (+,-) : BE0000013 Adenosine receptor A1 Pharmacological target (+,-) : BE0000924 Adenosine receptor A2a Non-common off-target(s) (drug1) : BE0000241 Adenosine receptor A2b (1) BE0000354 Adenosine receptor A3 (1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0001096 5'-nucleotidase (-1) --------------------------------------------------- Drug1 : DB00640 Adenosine Drug2 : DB00824 Enprofylline Pharmacological target (+,-) : BE0000241 Adenosine receptor A2b Non-common off-target(s) (drug1) : BE0000013 Adenosine receptor A1 (1) BE0000924 Adenosine receptor A2a (1) BE0000354 Adenosine receptor A3 (1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB00640 Adenosine Drug2 : DB01223 Aminophylline Pharmacological target (+,-) : BE0000013 Adenosine receptor A1 Pharmacological target (+,-) : BE0000354 Adenosine receptor A3 Non-common off-target(s) (drug1) : BE0000924 Adenosine receptor A2a (1) BE0000241 Adenosine receptor A2b (1) Non-common off-target(s) (drug2) : BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) --------------------------------------------------- Drug1 : DB00640 Adenosine Drug2 : DB01303 Oxtriphylline Pharmacological target (+,-) : BE0000013 Adenosine receptor A1 Pharmacological target (+,-) : BE0000924 Adenosine receptor A2a Non-common off-target(s) (drug1) : BE0000241 Adenosine receptor A2b (1) BE0000354 Adenosine receptor A3 (1) Non-common off-target(s) (drug2) : BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB00640 Adenosine Drug2 : DB01412 Theobromine Pharmacological target (+,-) : BE0000013 Adenosine receptor A1 Pharmacological target (+,-) : BE0000924 Adenosine receptor A2a Non-common off-target(s) (drug1) : BE0000241 Adenosine receptor A2b (1) BE0000354 Adenosine receptor A3 (1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) --------------------------------------------------- Drug1 : DB00644 Gonadorelin Drug2 : DB01406 Danazol Pharmacological target (+,-) : BE0000203 Gonadotropin-releasing hormone receptor Pharmacological target (+,-) : BE0000472 Putative gonadotropin-releasing hormone II receptor Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00644 Gonadorelin Drug2 : DB06699 Degarelix Pharmacological target (+,-) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug1) : BE0000472 Putative gonadotropin-releasing hormone II receptor (1) --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB00652 Pentazocine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB00704 Naltrexone Pharmacological target (-,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB00844 Nalbuphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB01183 Naloxone Pharmacological target (-,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00648 Mitotane Drug2 : DB01011 Metyrapone Pharmacological target (+,-) : BE0000731 Cytochrome P450 11B1, mitochondrial --------------------------------------------------- Drug1 : DB00651 Dyphylline Drug2 : DB06213 Regadenoson Pharmacological target (+,-) : BE0000924 Adenosine receptor A2a Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0000013 Adenosine receptor A1 (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB00708 Sufentanil Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB00802 Alfentanil Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB00913 Anileridine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB00921 Buprenorphine Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB00956 Hydrocodone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB01081 Diphenoxylate Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB01192 Oxymorphone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB01209 Dezocine Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB01444 Dimethylthiambutene Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB01466 Ethylmorphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB06204 Tapentadol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00655 Estrone Drug2 : DB00947 Fulvestrant Pharmacological target (+,-) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00655 Estrone Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB00866 Alprenolol Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB01359 Penbutolol Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000797 5-hydroxytryptamine receptor 1B (-1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB01616 Alverine Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB06594 Agomelatine Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000515 Melatonin receptor type 1A (1) BE0000327 Melatonin receptor type 1B (1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB09014 Captodiame Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00657 Mecamylamine Drug2 : DB01245 Decamethonium Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00665 Nilutamide Drug2 : DB00858 Drostanolone Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00665 Nilutamide Drug2 : DB00984 Nandrolone phenpropionate Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00665 Nilutamide Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000123 Estrogen receptor (-1) --------------------------------------------------- Drug1 : DB00665 Nilutamide Drug2 : DB01406 Danazol Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00665 Nilutamide Drug2 : DB01420 Testosterone Propionate Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00665 Nilutamide Drug2 : DB01481 Delta1-dihydrotestosterone Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00665 Nilutamide Drug2 : DB01541 Boldenone Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00665 Nilutamide Drug2 : DB06710 Methyltestosterone Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00665 Nilutamide Drug2 : DB08804 Nandrolone decanoate Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00666 Nafarelin Drug2 : DB01406 Danazol Pharmacological target (+,-) : BE0000203 Gonadotropin-releasing hormone receptor Pharmacological target (+,-) : BE0000472 Putative gonadotropin-releasing hormone II receptor Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00666 Nafarelin Drug2 : DB06699 Degarelix Pharmacological target (+,-) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug1) : BE0000472 Putative gonadotropin-releasing hormone II receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00719 Azatadine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00737 Meclizine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00748 Carbinoxamine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00751 Epinastine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Pharmacological target (+,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug1) : BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00767 Benzquinamide Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00768 Olopatadine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00777 Propiomazine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00792 Tripelennamine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00835 Brompheniramine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00863 Ranitidine Pharmacological target (+,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00902 Methdilazine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00920 Ketotifen Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00927 Famotidine Pharmacological target (+,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00940 Methantheline Pharmacological target (+,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00950 Fexofenadine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00967 Desloratadine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00972 Azelastine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB00985 Dimenhydrinate Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB01069 Promethazine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB01071 Mequitazine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB01075 Diphenhydramine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB01084 Emedastine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB01106 Levocabastine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB01114 Chlorphenamine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB01142 Doxepin Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Pharmacological target (+,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug1) : BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB01146 Diphenylpyraline Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB01173 Orphenadrine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB01176 Cyclizine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB01246 Alimemazine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB01615 Aceprometazine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB01619 Phenindamine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB01620 Pheniramine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB04837 Clofedanol Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB04890 Bepotastine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB06691 Mepyramine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB08799 Antazoline Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB08800 Chloropyramine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB08801 Dimetindene Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB08802 Isothipendyl Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB08805 Metiamide Pharmacological target (+,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB08806 Roxatidine acetate Pharmacological target (+,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB08936 Chlorcyclizine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) --------------------------------------------------- Drug1 : DB00667 Histamine Phosphate Drug2 : DB09016 Butriptyline Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000112 Histamine H2 receptor (1) BE0000146 Histamine H4 receptor (1) BE0000968 Histamine H3 receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB00679 Thioridazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB00692 Phentolamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB00699 Nicergoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB00831 Trifluoperazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB00866 Alprenolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB00875 Flupentixol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB01118 Amiodarone Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB01210 Levobunolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB01214 Metipranolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB01297 Practolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00668 Epinephrine Drug2 : DB01622 Thioproperazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00669 Sumatriptan Drug2 : DB00866 Alprenolol Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00669 Sumatriptan Drug2 : DB01142 Doxepin Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00669 Sumatriptan Drug2 : DB01149 Nefazodone Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00669 Sumatriptan Drug2 : DB01614 Acepromazine Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00669 Sumatriptan Drug2 : DB01616 Alverine Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) --------------------------------------------------- Drug1 : DB00669 Sumatriptan Drug2 : DB01621 Pipotiazine Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00669 Sumatriptan Drug2 : DB01622 Thioproperazine Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00677 Isoflurophate Drug2 : DB00733 Pralidoxime Pharmacological target (+,-) : BE0000426 Acetylcholinesterase Pharmacological target (+,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB00800 Fenoldopam Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB00865 Benzphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB00964 Apraclonidine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB01235 L-DOPA Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB01253 Ergonovine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01205 Flumazenil Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,-) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00687 Fludrocortisone Drug2 : DB00700 Eplerenone Pharmacological target (+,-) : BE0000668 Mineralocorticoid receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01205 Flumazenil Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,-) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB00723 Methoxamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB00865 Benzphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB00935 Oxymetazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB00964 Apraclonidine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB01018 Guanfacine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB01253 Ergonovine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB01363 Ephedra Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB01577 Methamphetamine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB01579 Phendimetrazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB04948 Lofexidine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB06694 Xylometazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor --------------------------------------------------- Drug1 : DB00696 Ergotamine Drug2 : DB00699 Nicergoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00696 Ergotamine Drug2 : DB00924 Cyclobenzaprine Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00696 Ergotamine Drug2 : DB01162 Terazosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (+,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00696 Ergotamine Drug2 : DB09016 Butriptyline Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB00723 Methoxamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB00865 Benzphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB00935 Oxymetazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB00964 Apraclonidine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB01253 Ergonovine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB01579 Phendimetrazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB06694 Xylometazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00700 Eplerenone Drug2 : DB01134 Desoxycorticosterone Pivalate Pharmacological target (+,-) : BE0000668 Mineralocorticoid receptor --------------------------------------------------- Drug1 : DB00704 Naltrexone Drug2 : DB00802 Alfentanil Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00704 Naltrexone Drug2 : DB00836 Loperamide Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000290 HCG20471, isoform CRA_c (-1) Non-common off-target(s) (drug2) : BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00704 Naltrexone Drug2 : DB00913 Anileridine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00704 Naltrexone Drug2 : DB00956 Hydrocodone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00704 Naltrexone Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) BE0000290 HCG20471, isoform CRA_c (-1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00704 Naltrexone Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00704 Naltrexone Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00704 Naltrexone Drug2 : DB01466 Ethylmorphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00704 Naltrexone Drug2 : DB01497 Etorphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000290 HCG20471, isoform CRA_c (-1) Non-common off-target(s) (drug2) : BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00704 Naltrexone Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000290 HCG20471, isoform CRA_c (-1) --------------------------------------------------- Drug1 : DB00704 Naltrexone Drug2 : DB06204 Tapentadol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) BE0000290 HCG20471, isoform CRA_c (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00704 Naltrexone Drug2 : DB06738 Ketobemidone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000290 HCG20471, isoform CRA_c (-1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00706 Tamsulosin Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00706 Tamsulosin Drug2 : DB00865 Benzphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00706 Tamsulosin Drug2 : DB00964 Apraclonidine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00706 Tamsulosin Drug2 : DB01253 Ergonovine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00706 Tamsulosin Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00706 Tamsulosin Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00706 Tamsulosin Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00706 Tamsulosin Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00708 Sufentanil Drug2 : DB06800 Methylnaltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00708 Sufentanil Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00714 Apomorphine Drug2 : DB01100 Pimozide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0000666 Neuron-specific vesicular protein calcyon (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00714 Apomorphine Drug2 : DB01184 Domperidone Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0000666 Neuron-specific vesicular protein calcyon (1) --------------------------------------------------- Drug1 : DB00714 Apomorphine Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0000666 Neuron-specific vesicular protein calcyon (1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00714 Apomorphine Drug2 : DB01425 Alizapride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0000666 Neuron-specific vesicular protein calcyon (1) --------------------------------------------------- Drug1 : DB00714 Apomorphine Drug2 : DB09018 Bromopride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0000666 Neuron-specific vesicular protein calcyon (1) --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00721 Procaine Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00723 Methoxamine Drug2 : DB00797 Tolazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) --------------------------------------------------- Drug1 : DB00723 Methoxamine Drug2 : DB00831 Trifluoperazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00723 Methoxamine Drug2 : DB00875 Flupentixol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00724 Imiquimod Drug2 : DB01611 Hydroxychloroquine Pharmacological target (+,-) : BE0000155 Toll-like receptor 7 Non-common off-target(s) (drug1) : BE0003518 Toll-like receptor 8 (1) Non-common off-target(s) (drug2) : BE0001171 Toll-like receptor 9 (-1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB01019 Bethanechol Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00726 Trimipramine Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00726 Trimipramine Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00728 Rocuronium Drug2 : DB01019 Bethanechol Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00728 Rocuronium Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) --------------------------------------------------- Drug1 : DB00728 Rocuronium Drug2 : DB01245 Decamethonium Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00729 Diphemanil Methylsulfate Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00729 Diphemanil Methylsulfate Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 --------------------------------------------------- Drug1 : DB00732 Atracurium Drug2 : DB01245 Decamethonium Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00733 Pralidoxime Drug2 : DB00772 Malathion Pharmacological target (+,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (1) --------------------------------------------------- Drug1 : DB00733 Pralidoxime Drug2 : DB00805 Minaprine Pharmacological target (+,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00733 Pralidoxime Drug2 : DB00843 Donepezil Pharmacological target (+,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) --------------------------------------------------- Drug1 : DB00733 Pralidoxime Drug2 : DB00941 Hexafluronium Pharmacological target (+,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (1) --------------------------------------------------- Drug1 : DB00733 Pralidoxime Drug2 : DB00981 Physostigmine Pharmacological target (+,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) --------------------------------------------------- Drug1 : DB00733 Pralidoxime Drug2 : DB00989 Rivastigmine Pharmacological target (+,-) : BE0000426 Acetylcholinesterase Pharmacological target (+,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00733 Pralidoxime Drug2 : DB01010 Edrophonium Pharmacological target (+,-) : BE0000426 Acetylcholinesterase Pharmacological target (+,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00733 Pralidoxime Drug2 : DB01057 Echothiophate Pharmacological target (+,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (1) --------------------------------------------------- Drug1 : DB00733 Pralidoxime Drug2 : DB01122 Ambenonium Pharmacological target (+,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) --------------------------------------------------- Drug1 : DB00733 Pralidoxime Drug2 : DB01400 Neostigmine Pharmacological target (+,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) --------------------------------------------------- Drug1 : DB00733 Pralidoxime Drug2 : DB08996 Dimetacrine Pharmacological target (+,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) --------------------------------------------------- Drug1 : DB00734 Risperidone Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00734 Risperidone Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00745 Modafinil Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00747 Scopolamine Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0001176 Sucrase-isomaltase, intestinal (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00753 Isoflurane Drug2 : DB01373 Calcium Pharmacological target (+,-) : BE0000218 Calcium-transporting ATPase type 2C member 1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0001024 Troponin C, slow skeletal and cardiac muscles (1) BE0003566 Troponin C, skeletal muscle (1) BE0004593 Spectrin beta chain, non-erythrocytic 1 (1) --------------------------------------------------- Drug1 : DB00753 Isoflurane Drug2 : DB06637 Dalfampridine Pharmacological target (+,-) : BE0000781 Potassium voltage-gated channel subfamily A member 1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0004502 Potassium voltage-gated channel subfamily A member 4 (-1) BE0004715 Potassium voltage-gated channel subfamily A member 2 (-1) BE0004716 Potassium voltage-gated channel subfamily A member 3 (-1) BE0004717 Potassium voltage-gated channel subfamily A member 5 (-1) BE0004718 Potassium voltage-gated channel subfamily A member 6 (-1) BE0004719 Potassium voltage-gated channel subfamily A member 7 (-1) BE0004720 Potassium voltage-gated channel subfamily A member 10 (-1) BE0004721 Potassium voltage-gated channel subfamily B member 1 (-1) BE0004722 Potassium voltage-gated channel subfamily B member 2 (-1) BE0004723 Potassium voltage-gated channel subfamily C member 1 (-1) BE0004724 Potassium voltage-gated channel subfamily C member 2 (-1) BE0004725 Potassium voltage-gated channel subfamily C member 3 (-1) BE0004726 Potassium voltage-gated channel subfamily D member 1 (-1) --------------------------------------------------- Drug1 : DB00758 Clopidogrel Drug2 : DB01240 Epoprostenol Pharmacological target (+,-) : BE0000110 P2Y purinoceptor 12 Non-common off-target(s) (drug2) : BE0000475 Prostacyclin receptor (1) BE0000117 Prostacyclin synthase (1) --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01019 Bethanechol Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00771 Clidinium Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00771 Clidinium Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00782 Propantheline Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00782 Propantheline Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00783 Estradiol Drug2 : DB00947 Fulvestrant Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00783 Estradiol Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00785 Cryptenamine Drug2 : DB01019 Bethanechol Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00785 Cryptenamine Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00785 Cryptenamine Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00785 Cryptenamine Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00797 Tolazoline Drug2 : DB01253 Ergonovine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) --------------------------------------------------- Drug1 : DB00797 Tolazoline Drug2 : DB01579 Phendimetrazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00797 Tolazoline Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00797 Tolazoline Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00800 Fenoldopam Drug2 : DB00850 Perphenazine Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000145 D(1B) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00800 Fenoldopam Drug2 : DB00875 Flupentixol Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000145 D(1B) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00800 Fenoldopam Drug2 : DB01038 Carphenazine Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Pharmacological target (+,-) : BE0000145 D(1B) dopamine receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00800 Fenoldopam Drug2 : DB01063 Acetophenazine Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000145 D(1B) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00800 Fenoldopam Drug2 : DB01239 Chlorprothixene Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000145 D(1B) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00800 Fenoldopam Drug2 : DB01614 Acepromazine Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000145 D(1B) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00800 Fenoldopam Drug2 : DB01621 Pipotiazine Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000145 D(1B) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00800 Fenoldopam Drug2 : DB01623 Thiothixene Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000145 D(1B) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,-) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB00844 Nalbuphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB01183 Naloxone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB01548 Diprenorphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB06274 Alvimopan Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB06800 Methylnaltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor --------------------------------------------------- Drug1 : DB00804 Dicyclomine Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00806 Pentoxifylline Drug2 : DB06213 Regadenoson Pharmacological target (+,-) : BE0000924 Adenosine receptor A2a Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0001096 5'-nucleotidase (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB01245 Decamethonium Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00812 Phenylbutazone Drug2 : DB01240 Epoprostenol Pharmacological target (+,-) : BE0000117 Prostacyclin synthase Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) Non-common off-target(s) (drug2) : BE0000110 P2Y purinoceptor 12 (1) BE0000475 Prostacyclin receptor (1) --------------------------------------------------- Drug1 : DB00813 Fentanyl Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB00866 Alprenolol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB01210 Levobunolol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB01214 Metipranolol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00823 Ethynodiol Drug2 : DB00834 Mifepristone Pharmacological target (+,-) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) Non-common off-target(s) (drug2) : BE0000794 Glucocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00823 Ethynodiol Drug2 : DB00947 Fulvestrant Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00823 Ethynodiol Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,-) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB00852 Pseudoephedrine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB00865 Benzphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB00935 Oxymetazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB00964 Apraclonidine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB01235 L-DOPA Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB01253 Ergonovine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB01579 Phendimetrazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB05271 Rotigotine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000572 Alpha-2B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB06694 Xylometazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB00838 Clocortolone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB00846 Flurandrenolide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB00860 Prednisolone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB00873 Loteprednol Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB00896 Rimexolone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB00957 Norgestimate Pharmacological target (+,-) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB00959 Methylprednisolone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB01047 Fluocinonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (-1) Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB01130 Prednicarbate Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB01234 Dexamethasone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (-1) Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB01260 Desonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB01380 Cortisone acetate Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB01384 Paramethasone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB01395 Drospirenone Pharmacological target (+,-) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000132 Androgen receptor (-1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB01406 Danazol Pharmacological target (+,-) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB01410 Ciclesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB01431 Allylestrenol Pharmacological target (+,-) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB06713 Norelgestromin Pharmacological target (+,-) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB06781 Difluprednate Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00836 Loperamide Drug2 : DB00844 Nalbuphine Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00836 Loperamide Drug2 : DB01183 Naloxone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB00836 Loperamide Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01205 Flumazenil Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00838 Clocortolone Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00841 Dobutamine Drug2 : DB01118 Amiodarone Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB00841 Dobutamine Drug2 : DB01297 Practolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,-) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00844 Nalbuphine Drug2 : DB00913 Anileridine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00844 Nalbuphine Drug2 : DB00956 Hydrocodone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00844 Nalbuphine Drug2 : DB01209 Dezocine Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00844 Nalbuphine Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (-1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00844 Nalbuphine Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00844 Nalbuphine Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00844 Nalbuphine Drug2 : DB01466 Ethylmorphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00844 Nalbuphine Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00844 Nalbuphine Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00844 Nalbuphine Drug2 : DB06204 Tapentadol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00844 Nalbuphine Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00846 Flurandrenolide Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00848 Levamisole Drug2 : DB01090 Pentolinium Pharmacological target (+,-) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 Non-common off-target(s) (drug1) : BE0000896 Alkaline phosphatase, placental-like (-1) Non-common off-target(s) (drug2) : BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0003584 Neuronal acetylcholine receptor subunit beta-4 (-1) --------------------------------------------------- Drug1 : DB00849 Methylphenobarbital Drug2 : DB01205 Flumazenil Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB01235 L-DOPA Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB00875 Flupentixol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB00925 Phenoxybenzamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB01162 Terazosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB01392 Yohimbine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB01608 Propericiazine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB01622 Thioproperazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB06207 Silodosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00854 Levorphanol Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00858 Drostanolone Drug2 : DB01128 Bicalutamide Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00858 Drostanolone Drug2 : DB01395 Drospirenone Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00858 Drostanolone Drug2 : DB04839 Cyproterone acetate Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00858 Drostanolone Drug2 : DB08899 Enzalutamide Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00860 Prednisolone Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB00875 Flupentixol Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB00925 Phenoxybenzamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB01089 Deserpidine Pharmacological target (+,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB01162 Terazosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB01392 Yohimbine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000501 Alpha-1A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB01608 Propericiazine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000501 Alpha-1A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB01622 Thioproperazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB04844 Tetrabenazine Pharmacological target (+,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB06207 Silodosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB00867 Ritodrine Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB00871 Terbutaline Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB00938 Salmeterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB00952 Naratriptan Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB00983 Formoterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB01064 Isoprenaline Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (-1) Non-common off-target(s) (drug2) : BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB01274 Arformoterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB01363 Ephedra Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB01366 Procaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB01408 Bambuterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB05039 Indacaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (-1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB08810 Cinitapride Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB09080 Olodaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00867 Ritodrine Drug2 : DB01210 Levobunolol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00867 Ritodrine Drug2 : DB01214 Metipranolol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00871 Terbutaline Drug2 : DB01210 Levobunolol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00871 Terbutaline Drug2 : DB01214 Metipranolol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00873 Loteprednol Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB00915 Amantadine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB00935 Oxymetazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB00964 Apraclonidine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB01235 L-DOPA Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB01253 Ergonovine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB01579 Phendimetrazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB06694 Xylometazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00890 Dienestrol Drug2 : DB00947 Fulvestrant Pharmacological target (+,-) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00890 Dienestrol Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00896 Rimexolone Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,-) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00898 Ethanol Drug2 : DB01205 Flumazenil Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0000745 Glycine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00899 Remifentanil Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB01183 Naloxone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB01548 Diprenorphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB06274 Alvimopan Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB06800 Methylnaltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB00933 Mesoridazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01038 Carphenazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01063 Acetophenazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01100 Pimozide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000581 D(3) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01184 Domperidone Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01224 Quetiapine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01239 Chlorprothixene Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01267 Paliperidone Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01403 Methotrimeprazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01425 Alizapride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01614 Acepromazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01618 Molindone Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01621 Pipotiazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01622 Thioproperazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01623 Thiothixene Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01624 Zuclopenthixol Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB04842 Fluspirilene Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB04946 Iloperidone Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB06144 Sertindole Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB06216 Asenapine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) BE0004688 5-hydroxytryptamine receptor 5A (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB06288 Amisulpride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB08815 Lurasidone Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB09018 Bromopride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00920 Ketotifen Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00921 Buprenorphine Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00922 Levosimendan Drug2 : DB01154 Thiamylal Pharmacological target (+,-) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 Pharmacological target (+,-) : BE0002441 ATP-sensitive inward rectifier potassium channel 8 Non-common off-target(s) (drug1) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0001024 Troponin C, slow skeletal and cardiac muscles (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00922 Levosimendan Drug2 : DB01251 Gliquidone Pharmacological target (+,-) : BE0002441 ATP-sensitive inward rectifier potassium channel 8 Non-common off-target(s) (drug1) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0001024 Troponin C, slow skeletal and cardiac muscles (1) Non-common off-target(s) (drug2) : BE0000207 ATP-binding cassette sub-family C member 8 (-1) --------------------------------------------------- Drug1 : DB00922 Levosimendan Drug2 : DB01289 Glisoxepide Pharmacological target (+,-) : BE0002441 ATP-sensitive inward rectifier potassium channel 8 Non-common off-target(s) (drug1) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0001024 Troponin C, slow skeletal and cardiac muscles (1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00925 Phenoxybenzamine Drug2 : DB01018 Guanfacine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00925 Phenoxybenzamine Drug2 : DB01253 Ergonovine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00925 Phenoxybenzamine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00925 Phenoxybenzamine Drug2 : DB04948 Lofexidine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00925 Phenoxybenzamine Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00925 Phenoxybenzamine Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00925 Phenoxybenzamine Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01235 L-DOPA Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB05271 Rotigotine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000572 Alpha-2B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00934 Maprotiline Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00934 Maprotiline Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB00988 Dopamine Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00938 Salmeterol Drug2 : DB01210 Levobunolol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00938 Salmeterol Drug2 : DB01214 Metipranolol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00942 Cycrimine Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00942 Cycrimine Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00947 Fulvestrant Drug2 : DB00957 Norgestimate Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00947 Fulvestrant Drug2 : DB00977 Ethinyl Estradiol Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00947 Fulvestrant Drug2 : DB01196 Estramustine Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) --------------------------------------------------- Drug1 : DB00947 Fulvestrant Drug2 : DB01357 Mestranol Pharmacological target (+,-) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00947 Fulvestrant Drug2 : DB01406 Danazol Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB00947 Fulvestrant Drug2 : DB04573 Estriol Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00947 Fulvestrant Drug2 : DB04574 Estropipate Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00947 Fulvestrant Drug2 : DB04575 Quinestrol Pharmacological target (+,-) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00952 Naratriptan Drug2 : DB01142 Doxepin Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00952 Naratriptan Drug2 : DB01149 Nefazodone Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00952 Naratriptan Drug2 : DB01614 Acepromazine Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00952 Naratriptan Drug2 : DB01616 Alverine Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) --------------------------------------------------- Drug1 : DB00952 Naratriptan Drug2 : DB01621 Pipotiazine Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00952 Naratriptan Drug2 : DB01622 Thioproperazine Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000460 5-hydroxytryptamine receptor 1F (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00956 Hydrocodone Drug2 : DB01183 Naloxone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB00956 Hydrocodone Drug2 : DB01548 Diprenorphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00956 Hydrocodone Drug2 : DB06800 Methylnaltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00956 Hydrocodone Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00957 Norgestimate Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00959 Methylprednisolone Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00960 Pindolol Drug2 : DB01118 Amiodarone Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) BE0000291 5-hydroxytryptamine receptor 1A (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB00960 Pindolol Drug2 : DB01297 Practolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01205 Flumazenil Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00964 Apraclonidine Drug2 : DB01162 Terazosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00964 Apraclonidine Drug2 : DB01608 Propericiazine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00964 Apraclonidine Drug2 : DB01622 Thioproperazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00964 Apraclonidine Drug2 : DB06207 Silodosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00977 Ethinyl Estradiol Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00979 Cyclopentolate Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00979 Cyclopentolate Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00983 Formoterol Drug2 : DB01210 Levobunolol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00983 Formoterol Drug2 : DB01214 Metipranolol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00984 Nandrolone phenpropionate Drug2 : DB01128 Bicalutamide Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00984 Nandrolone phenpropionate Drug2 : DB01395 Drospirenone Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00984 Nandrolone phenpropionate Drug2 : DB04839 Cyproterone acetate Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00984 Nandrolone phenpropionate Drug2 : DB08899 Enzalutamide Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB00986 Glycopyrrolate Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01038 Carphenazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Pharmacological target (+,-) : BE0000145 D(1B) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01063 Acetophenazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01100 Pimozide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01105 Sibutramine Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01156 Bupropion Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01184 Domperidone Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01239 Chlorprothixene Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01255 Lisdexamfetamine Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01363 Ephedra Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01425 Alizapride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01463 Fencamfamine Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01576 Dextroamphetamine Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01577 Methamphetamine Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01608 Propericiazine Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000756 D(2) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01614 Acepromazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01618 Molindone Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01621 Pipotiazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01623 Thiothixene Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01624 Zuclopenthixol Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Pharmacological target (+,-) : BE0000145 D(1B) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB04842 Fluspirilene Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB06144 Sertindole Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB06701 Dexmethylphenidate Pharmacological target (+,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB08815 Lurasidone Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB09018 Bromopride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00995 Auranofin Drug2 : DB01169 Arsenic trioxide Pharmacological target (+,-) : BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta Non-common off-target(s) (drug1) : BE0000907 Peroxiredoxin-5, mitochondrial (-1) Non-common off-target(s) (drug2) : BE0000428 RAC-alpha serine/threonine-protein kinase (1) BE0001040 Transcription factor AP-1 (1) BE0001062 Mitogen-activated protein kinase 3 (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0001979 Thioredoxin reductase 1, cytoplasmic (-1) BE0001027 G1/S-specific cyclin-D1 (-1) --------------------------------------------------- Drug1 : DB01013 Clobetasol propionate Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01018 Guanfacine Drug2 : DB01392 Yohimbine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01018 Guanfacine Drug2 : DB01608 Propericiazine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01019 Bethanechol Drug2 : DB01036 Tolterodine Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01019 Bethanechol Drug2 : DB01062 Oxybutynin Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB01019 Bethanechol Drug2 : DB01142 Doxepin Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01019 Bethanechol Drug2 : DB01148 Flavoxate Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB01019 Bethanechol Drug2 : DB01231 Diphenidol Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB01019 Bethanechol Drug2 : DB08801 Dimetindene Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB01019 Bethanechol Drug2 : DB08897 Aclidinium Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01019 Bethanechol Drug2 : DB09076 Umeclidinium Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01022 Phylloquinone Drug2 : DB01125 Anisindione Pharmacological target (+,-) : BE0000403 Vitamin K-dependent gamma-carboxylase Non-common off-target(s) (drug1) : BE0000724 Osteocalcin (1) --------------------------------------------------- Drug1 : DB01028 Methoxyflurane Drug2 : DB06637 Dalfampridine Pharmacological target (+,-) : BE0000781 Potassium voltage-gated channel subfamily A member 1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0004502 Potassium voltage-gated channel subfamily A member 4 (-1) BE0004715 Potassium voltage-gated channel subfamily A member 2 (-1) BE0004716 Potassium voltage-gated channel subfamily A member 3 (-1) BE0004717 Potassium voltage-gated channel subfamily A member 5 (-1) BE0004718 Potassium voltage-gated channel subfamily A member 6 (-1) BE0004719 Potassium voltage-gated channel subfamily A member 7 (-1) BE0004720 Potassium voltage-gated channel subfamily A member 10 (-1) BE0004721 Potassium voltage-gated channel subfamily B member 1 (-1) BE0004722 Potassium voltage-gated channel subfamily B member 2 (-1) BE0004723 Potassium voltage-gated channel subfamily C member 1 (-1) BE0004724 Potassium voltage-gated channel subfamily C member 2 (-1) BE0004725 Potassium voltage-gated channel subfamily C member 3 (-1) BE0004726 Potassium voltage-gated channel subfamily D member 1 (-1) --------------------------------------------------- Drug1 : DB01036 Tolterodine Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01036 Tolterodine Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01036 Tolterodine Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01038 Carphenazine Drug2 : DB01235 L-DOPA Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Pharmacological target (+,-) : BE0000145 D(1B) dopamine receptor Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB01047 Fluocinonide Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB01062 Oxybutynin Drug2 : DB01085 Pilocarpine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB01062 Oxybutynin Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01062 Oxybutynin Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01063 Acetophenazine Drug2 : DB01235 L-DOPA Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB01064 Isoprenaline Drug2 : DB01118 Amiodarone Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB01064 Isoprenaline Drug2 : DB01210 Levobunolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB01064 Isoprenaline Drug2 : DB01214 Metipranolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB01064 Isoprenaline Drug2 : DB01297 Practolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0000923 Mitogen-activated protein kinase 1 (1) BE0000955 Phosphatidylinositol 3-kinase regulatory subunit alpha (1) BE0002383 Phosphatidylinositol 3-kinase regulatory subunit beta (1) BE0002384 Phosphatidylinositol 3-kinase regulatory subunit gamma (1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB01081 Diphenoxylate Drug2 : DB06800 Methylnaltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01081 Diphenoxylate Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB01085 Pilocarpine Drug2 : DB01142 Doxepin Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01085 Pilocarpine Drug2 : DB01148 Flavoxate Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) --------------------------------------------------- Drug1 : DB01085 Pilocarpine Drug2 : DB01231 Diphenidol Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB01085 Pilocarpine Drug2 : DB01625 Isopropamide Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000560 Muscarinic acetylcholine receptor M2 (1) Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB01085 Pilocarpine Drug2 : DB04843 Mepenzolate Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB01085 Pilocarpine Drug2 : DB08801 Dimetindene Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB01085 Pilocarpine Drug2 : DB08897 Aclidinium Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01089 Deserpidine Drug2 : DB01576 Dextroamphetamine Pharmacological target (+,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01100 Pimozide Drug2 : DB01186 Pergolide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01100 Pimozide Drug2 : DB01200 Bromocriptine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01100 Pimozide Drug2 : DB01235 L-DOPA Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB01100 Pimozide Drug2 : DB05271 Rotigotine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000572 Alpha-2B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01100 Pimozide Drug2 : DB09014 Captodiame Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB01102 Arbutamine Drug2 : DB01118 Amiodarone Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB01102 Arbutamine Drug2 : DB01297 Practolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01105 Sibutramine Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01105 Sibutramine Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB01108 Trilostane Drug2 : DB01536 4-Androstenedione Pharmacological target (+,-) : BE0000051 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 Non-common off-target(s) (drug1) : BE0000059 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (-1) Non-common off-target(s) (drug2) : BE0000194 Estradiol 17-beta-dehydrogenase 1 (1) BE0000592 Aldo-keto reductase family 1 member C3 (1) --------------------------------------------------- Drug1 : DB01114 Chlorphenamine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB01118 Amiodarone Drug2 : DB01193 Acebutolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01118 Amiodarone Drug2 : DB01363 Ephedra Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01118 Amiodarone Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01118 Amiodarone Drug2 : DB08807 Bopindolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01119 Diazoxide Drug2 : DB01154 Thiamylal Pharmacological target (+,-) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) --------------------------------------------------- Drug1 : DB01128 Bicalutamide Drug2 : DB01185 Fluoxymesterone Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000123 Estrogen receptor (-1) --------------------------------------------------- Drug1 : DB01128 Bicalutamide Drug2 : DB01406 Danazol Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug2) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB01128 Bicalutamide Drug2 : DB01420 Testosterone Propionate Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01128 Bicalutamide Drug2 : DB01481 Delta1-dihydrotestosterone Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01128 Bicalutamide Drug2 : DB01541 Boldenone Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01128 Bicalutamide Drug2 : DB06710 Methyltestosterone Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01128 Bicalutamide Drug2 : DB08804 Nandrolone decanoate Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01130 Prednicarbate Drug2 : DB01222 Budesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01134 Desoxycorticosterone Pivalate Drug2 : DB01395 Drospirenone Pharmacological target (+,-) : BE0000668 Mineralocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (-1) --------------------------------------------------- Drug1 : DB01135 Doxacurium chloride Drug2 : DB01245 Decamethonium Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB01136 Carvedilol Drug2 : DB01253 Ergonovine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000173 NADH dehydrogenase [ubiquinone] 1 subunit C2 (-1) BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0001114 Vascular cell adhesion protein 1 (-1) BE0001074 E-selectin (-1) --------------------------------------------------- Drug1 : DB01136 Carvedilol Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000173 NADH dehydrogenase [ubiquinone] 1 subunit C2 (-1) BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0001114 Vascular cell adhesion protein 1 (-1) BE0001074 E-selectin (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB01136 Carvedilol Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000173 NADH dehydrogenase [ubiquinone] 1 subunit C2 (-1) BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0001114 Vascular cell adhesion protein 1 (-1) BE0001074 E-selectin (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01146 Diphenylpyraline Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB01148 Flavoxate Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01149 Nefazodone Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01149 Nefazodone Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01151 Desipramine Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB01151 Desipramine Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB01154 Thiamylal Drug2 : DB01205 Flumazenil Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB01156 Bupropion Drug2 : DB01170 Guanethidine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB01156 Bupropion Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB01162 Terazosin Drug2 : DB01253 Ergonovine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB01162 Terazosin Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01162 Terazosin Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (+,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01162 Terazosin Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB01162 Terazosin Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01162 Terazosin Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01170 Guanethidine Drug2 : DB01173 Orphenadrine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01170 Guanethidine Drug2 : DB01363 Ephedra Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01170 Guanethidine Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01170 Guanethidine Drug2 : DB01454 3,4-Methylenedioxymethamphetamine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01170 Guanethidine Drug2 : DB01576 Dextroamphetamine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01170 Guanethidine Drug2 : DB01577 Methamphetamine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01170 Guanethidine Drug2 : DB01579 Phendimetrazine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01170 Guanethidine Drug2 : DB04896 Milnacipran Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01170 Guanethidine Drug2 : DB06204 Tapentadol Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000770 Mu-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01170 Guanethidine Drug2 : DB06700 Desvenlafaxine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB01170 Guanethidine Drug2 : DB06701 Dexmethylphenidate Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01170 Guanethidine Drug2 : DB08918 Levomilnacipran Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000442 Histamine H1 receptor (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01173 Orphenadrine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB01174 Phenobarbital Drug2 : DB01205 Flumazenil Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB01176 Cyclizine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000951 Estrogen sulfotransferase (-1) Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB01183 Naloxone Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB01183 Naloxone Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB01183 Naloxone Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB01183 Naloxone Drug2 : DB01466 Ethylmorphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB01183 Naloxone Drug2 : DB01497 Etorphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) Non-common off-target(s) (drug2) : BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB01183 Naloxone Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB01183 Naloxone Drug2 : DB06204 Tapentadol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01183 Naloxone Drug2 : DB06738 Ketobemidone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB01186 Pergolide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB01200 Bromocriptine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB01235 L-DOPA Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB05271 Rotigotine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000572 Alpha-2B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB09014 Captodiame Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB01185 Fluoxymesterone Drug2 : DB01196 Estramustine Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) Non-common off-target(s) (drug2) : BE0001100 Microtubule-associated protein 2 (-1) BE0001169 Microtubule-associated protein 1A (-1) --------------------------------------------------- Drug1 : DB01185 Fluoxymesterone Drug2 : DB01357 Mestranol Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB01185 Fluoxymesterone Drug2 : DB01395 Drospirenone Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000123 Estrogen receptor (-1) Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB01185 Fluoxymesterone Drug2 : DB04573 Estriol Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB01185 Fluoxymesterone Drug2 : DB04574 Estropipate Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB01185 Fluoxymesterone Drug2 : DB04575 Quinestrol Pharmacological target (+,-) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB01185 Fluoxymesterone Drug2 : DB04839 Cyproterone acetate Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000123 Estrogen receptor (-1) --------------------------------------------------- Drug1 : DB01185 Fluoxymesterone Drug2 : DB08899 Enzalutamide Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000345 Prolactin receptor (-1) BE0000794 Glucocorticoid receptor (-1) BE0000123 Estrogen receptor (-1) --------------------------------------------------- Drug1 : DB01186 Pergolide Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01186 Pergolide Drug2 : DB01425 Alizapride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01186 Pergolide Drug2 : DB09018 Bromopride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01189 Desflurane Drug2 : DB01373 Calcium Pharmacological target (+,-) : BE0000218 Calcium-transporting ATPase type 2C member 1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) Non-common off-target(s) (drug2) : BE0001024 Troponin C, slow skeletal and cardiac muscles (1) BE0003566 Troponin C, skeletal muscle (1) BE0004593 Spectrin beta chain, non-erythrocytic 1 (1) --------------------------------------------------- Drug1 : DB01189 Desflurane Drug2 : DB06637 Dalfampridine Pharmacological target (+,-) : BE0000781 Potassium voltage-gated channel subfamily A member 1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) Non-common off-target(s) (drug2) : BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0004502 Potassium voltage-gated channel subfamily A member 4 (-1) BE0004715 Potassium voltage-gated channel subfamily A member 2 (-1) BE0004716 Potassium voltage-gated channel subfamily A member 3 (-1) BE0004717 Potassium voltage-gated channel subfamily A member 5 (-1) BE0004718 Potassium voltage-gated channel subfamily A member 6 (-1) BE0004719 Potassium voltage-gated channel subfamily A member 7 (-1) BE0004720 Potassium voltage-gated channel subfamily A member 10 (-1) BE0004721 Potassium voltage-gated channel subfamily B member 1 (-1) BE0004722 Potassium voltage-gated channel subfamily B member 2 (-1) BE0004723 Potassium voltage-gated channel subfamily C member 1 (-1) BE0004724 Potassium voltage-gated channel subfamily C member 2 (-1) BE0004725 Potassium voltage-gated channel subfamily C member 3 (-1) BE0004726 Potassium voltage-gated channel subfamily D member 1 (-1) --------------------------------------------------- Drug1 : DB01192 Oxymorphone Drug2 : DB06800 Methylnaltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01192 Oxymorphone Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01193 Acebutolol Drug2 : DB01297 Practolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01205 Flumazenil Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB01200 Bromocriptine Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01200 Bromocriptine Drug2 : DB01425 Alizapride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01200 Bromocriptine Drug2 : DB09018 Bromopride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,-) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01351 Amobarbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01352 Aprobarbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01353 Butethal Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01354 Heptabarbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01355 Hexobarbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01483 Barbital Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01544 Flunitrazepam Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01558 Bromazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,-) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01559 Clotiazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,-) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01567 Fludiazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,-) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01587 Ketazolam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (-1) BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,-) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,-) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01594 Cinolazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,-) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) --------------------------------------------------- Drug1 : DB01205 Flumazenil Drug2 : DB01595 Nitrazepam Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,-) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 (1) BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 (1) BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 (1) BE0003599 Gamma-aminobutyric acid receptor subunit delta (1) BE0003595 Gamma-aminobutyric acid receptor subunit epsilon (1) BE0003596 Gamma-aminobutyric acid receptor subunit pi (1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (1) BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 (1) BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01209 Dezocine Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01210 Levobunolol Drug2 : DB01274 Arformoterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01210 Levobunolol Drug2 : DB01363 Ephedra Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01210 Levobunolol Drug2 : DB01366 Procaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01210 Levobunolol Drug2 : DB01408 Bambuterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01210 Levobunolol Drug2 : DB05039 Indacaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01210 Levobunolol Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01210 Levobunolol Drug2 : DB09080 Olodaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01214 Metipranolol Drug2 : DB01274 Arformoterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01214 Metipranolol Drug2 : DB01363 Ephedra Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01214 Metipranolol Drug2 : DB01366 Procaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01214 Metipranolol Drug2 : DB01408 Bambuterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01214 Metipranolol Drug2 : DB05039 Indacaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01214 Metipranolol Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01214 Metipranolol Drug2 : DB09080 Olodaterol Pharmacological target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01222 Budesonide Drug2 : DB01234 Dexamethasone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB01222 Budesonide Drug2 : DB01260 Desonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01222 Budesonide Drug2 : DB01380 Cortisone acetate Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01222 Budesonide Drug2 : DB01384 Paramethasone Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01222 Budesonide Drug2 : DB01410 Ciclesonide Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01222 Budesonide Drug2 : DB06781 Difluprednate Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01222 Budesonide Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,-) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01223 Aminophylline Drug2 : DB02546 Vorinostat Pharmacological target (+,-) : BE0002366 Histone deacetylase 2 Non-common off-target(s) (drug1) : BE0000013 Adenosine receptor A1 (-1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0000354 Adenosine receptor A3 (-1) Non-common off-target(s) (drug2) : BE0002365 Histone deacetylase 1 (-1) BE0002367 Histone deacetylase 3 (-1) BE0002368 Histone deacetylase 6 (-1) --------------------------------------------------- Drug1 : DB01224 Quetiapine Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB01226 Mivacurium Drug2 : DB01245 Decamethonium Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB01227 Levomethadyl Acetate Drug2 : DB01548 Diprenorphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01227 Levomethadyl Acetate Drug2 : DB06274 Alvimopan Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01227 Levomethadyl Acetate Drug2 : DB06800 Methylnaltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01227 Levomethadyl Acetate Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB01229 Paclitaxel Drug2 : DB01367 Rasagiline Pharmacological target (+,-) : BE0000246 Apoptosis regulator Bcl-2 Non-common off-target(s) (drug1) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) BE0000026 Tubulin beta-1 chain (-1) Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) --------------------------------------------------- Drug1 : DB01231 Diphenidol Drug2 : DB01233 Metoclopramide Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01231 Diphenidol Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB01235 L-DOPA Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB04843 Mepenzolate Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB05271 Rotigotine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000572 Alpha-2B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB08897 Aclidinium Pharmacological target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01235 L-DOPA Drug2 : DB01239 Chlorprothixene Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Pharmacological target (+,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01235 L-DOPA Drug2 : DB01425 Alizapride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB01235 L-DOPA Drug2 : DB01608 Propericiazine Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01235 L-DOPA Drug2 : DB01614 Acepromazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01235 L-DOPA Drug2 : DB01618 Molindone Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01235 L-DOPA Drug2 : DB01621 Pipotiazine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01235 L-DOPA Drug2 : DB01623 Thiothixene Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01235 L-DOPA Drug2 : DB01624 Zuclopenthixol Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Pharmacological target (+,-) : BE0000020 D(1A) dopamine receptor Pharmacological target (+,-) : BE0000145 D(1B) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01235 L-DOPA Drug2 : DB04842 Fluspirilene Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB01235 L-DOPA Drug2 : DB06144 Sertindole Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB01235 L-DOPA Drug2 : DB08815 Lurasidone Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01235 L-DOPA Drug2 : DB09018 Bromopride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB01236 Sevoflurane Drug2 : DB01373 Calcium Pharmacological target (+,-) : BE0000218 Calcium-transporting ATPase type 2C member 1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0001024 Troponin C, slow skeletal and cardiac muscles (1) BE0003566 Troponin C, skeletal muscle (1) BE0004593 Spectrin beta chain, non-erythrocytic 1 (1) --------------------------------------------------- Drug1 : DB01236 Sevoflurane Drug2 : DB06637 Dalfampridine Pharmacological target (+,-) : BE0000781 Potassium voltage-gated channel subfamily A member 1 Non-common off-target(s) (drug1) : BE0000640 Glutamate receptor 1 (-1) BE0000433 Glycine receptor subunit alpha-1 (1) BE0004797 GABA-A receptor (anion channel) (1) BE0000218 Calcium-transporting ATPase type 2C member 1 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0004502 Potassium voltage-gated channel subfamily A member 4 (-1) BE0004715 Potassium voltage-gated channel subfamily A member 2 (-1) BE0004716 Potassium voltage-gated channel subfamily A member 3 (-1) BE0004717 Potassium voltage-gated channel subfamily A member 5 (-1) BE0004718 Potassium voltage-gated channel subfamily A member 6 (-1) BE0004719 Potassium voltage-gated channel subfamily A member 7 (-1) BE0004720 Potassium voltage-gated channel subfamily A member 10 (-1) BE0004721 Potassium voltage-gated channel subfamily B member 1 (-1) BE0004722 Potassium voltage-gated channel subfamily B member 2 (-1) BE0004723 Potassium voltage-gated channel subfamily C member 1 (-1) BE0004724 Potassium voltage-gated channel subfamily C member 2 (-1) BE0004725 Potassium voltage-gated channel subfamily C member 3 (-1) BE0004726 Potassium voltage-gated channel subfamily D member 1 (-1) --------------------------------------------------- Drug1 : DB01237 Bromodiphenhydramine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB01238 Aripiprazole Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB01239 Chlorprothixene Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB01240 Epoprostenol Drug2 : DB06209 Prasugrel Pharmacological target (+,-) : BE0000110 P2Y purinoceptor 12 Non-common off-target(s) (drug1) : BE0000475 Prostacyclin receptor (1) BE0000117 Prostacyclin synthase (1) --------------------------------------------------- Drug1 : DB01240 Epoprostenol Drug2 : DB08816 Ticagrelor Pharmacological target (+,-) : BE0000110 P2Y purinoceptor 12 Non-common off-target(s) (drug1) : BE0000475 Prostacyclin receptor (1) BE0000117 Prostacyclin synthase (1) --------------------------------------------------- Drug1 : DB01245 Decamethonium Drug2 : DB01336 Metocurine Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01245 Decamethonium Drug2 : DB01337 Pancuronium Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01245 Decamethonium Drug2 : DB01338 Pipecuronium Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01245 Decamethonium Drug2 : DB01339 Vecuronium Pharmacological target (+,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB01246 Alimemazine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB01253 Ergonovine Drug2 : DB01622 Thioproperazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01253 Ergonovine Drug2 : DB06207 Silodosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01267 Paliperidone Drug2 : DB01442 MMDA Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB01284 Cosyntropin Drug2 : DB01285 Corticotropin Pharmacological target (+,-) : BE0000848 Adrenocorticotropic hormone receptor Non-common off-target(s) (drug2) : BE0001026 Corticoliberin (1) --------------------------------------------------- Drug1 : DB01297 Practolol Drug2 : DB01363 Ephedra Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01297 Practolol Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01297 Practolol Drug2 : DB08807 Bopindolol Pharmacological target (+,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01303 Oxtriphylline Drug2 : DB02546 Vorinostat Pharmacological target (+,-) : BE0002366 Histone deacetylase 2 Non-common off-target(s) (drug1) : BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) Non-common off-target(s) (drug2) : BE0002365 Histone deacetylase 1 (-1) BE0002367 Histone deacetylase 3 (-1) BE0002368 Histone deacetylase 6 (-1) --------------------------------------------------- Drug1 : DB01303 Oxtriphylline Drug2 : DB06213 Regadenoson Pharmacological target (+,-) : BE0000924 Adenosine receptor A2a Non-common off-target(s) (drug1) : BE0000013 Adenosine receptor A1 (-1) BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB01359 Penbutolol Drug2 : DB08810 Cinitapride Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000797 5-hydroxytryptamine receptor 1B (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB01392 Yohimbine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (+,-) : BE0000572 Alpha-2B adrenergic receptor Pharmacological target (+,-) : BE0000342 Alpha-2C adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB01608 Propericiazine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01392 Yohimbine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01392 Yohimbine Drug2 : DB01577 Methamphetamine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (+,-) : BE0000572 Alpha-2B adrenergic receptor Pharmacological target (+,-) : BE0000342 Alpha-2C adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB01392 Yohimbine Drug2 : DB04948 Lofexidine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01392 Yohimbine Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (+,-) : BE0000572 Alpha-2B adrenergic receptor Pharmacological target (+,-) : BE0000342 Alpha-2C adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01392 Yohimbine Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01392 Yohimbine Drug2 : DB08838 Agmatine Pharmacological target (+,-) : BE0000342 Alpha-2C adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000365 Glutamate receptor ionotropic, NMDA 1 (-1) BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0004661 Acetylcholine receptor subunit alpha (-1) BE0003580 Nischarin (1) BE0004768 Acid-sensing ion channel 3 (1) --------------------------------------------------- Drug1 : DB01395 Drospirenone Drug2 : DB01420 Testosterone Propionate Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB01395 Drospirenone Drug2 : DB01481 Delta1-dihydrotestosterone Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB01395 Drospirenone Drug2 : DB01541 Boldenone Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB01395 Drospirenone Drug2 : DB06710 Methyltestosterone Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB01395 Drospirenone Drug2 : DB08804 Nandrolone decanoate Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB01406 Danazol Drug2 : DB04839 Cyproterone acetate Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB01406 Danazol Drug2 : DB08899 Enzalutamide Pharmacological target (+,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0000203 Gonadotropin-releasing hormone receptor (-1) BE0000123 Estrogen receptor (1) BE0000557 Progesterone receptor (1) BE0000472 Putative gonadotropin-releasing hormone II receptor (-1) BE0001047 C-C motif chemokine 2 (-1) --------------------------------------------------- Drug1 : DB01409 Tiotropium Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01412 Theobromine Drug2 : DB06213 Regadenoson Pharmacological target (+,-) : BE0000924 Adenosine receptor A2a Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000013 Adenosine receptor A1 (-1) --------------------------------------------------- Drug1 : DB01420 Testosterone Propionate Drug2 : DB04839 Cyproterone acetate Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01420 Testosterone Propionate Drug2 : DB08899 Enzalutamide Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01425 Alizapride Drug2 : DB05271 Rotigotine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000572 Alpha-2B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01433 Methadyl Acetate Drug2 : DB01548 Diprenorphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01433 Methadyl Acetate Drug2 : DB06274 Alvimopan Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01433 Methadyl Acetate Drug2 : DB06800 Methylnaltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01433 Methadyl Acetate Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor --------------------------------------------------- Drug1 : DB01439 3-Methylthiofentanyl Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB01614 Acepromazine Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB01621 Pipotiazine Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB01622 Thioproperazine Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB01623 Thiothixene Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB04946 Iloperidone Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB06144 Sertindole Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB06216 Asenapine Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000172 Beta-1 adrenergic receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) BE0004688 5-hydroxytryptamine receptor 5A (-1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB08810 Cinitapride Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB08815 Lurasidone Pharmacological target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01444 Dimethylthiambutene Drug2 : DB06800 Methylnaltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01444 Dimethylthiambutene Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01452 Heroin Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01454 3,4-Methylenedioxymethamphetamine Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01466 Ethylmorphine Drug2 : DB01548 Diprenorphine Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01466 Ethylmorphine Drug2 : DB06274 Alvimopan Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01466 Ethylmorphine Drug2 : DB06800 Methylnaltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01466 Ethylmorphine Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor --------------------------------------------------- Drug1 : DB01472 4-Methoxyamphetamine Drug2 : DB01608 Propericiazine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000501 Alpha-1A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01472 4-Methoxyamphetamine Drug2 : DB01622 Thioproperazine Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01472 4-Methoxyamphetamine Drug2 : DB06207 Silodosin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01481 Delta1-dihydrotestosterone Drug2 : DB04839 Cyproterone acetate Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01481 Delta1-dihydrotestosterone Drug2 : DB08899 Enzalutamide Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01497 Etorphine Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB01535 Carfentanil Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01541 Boldenone Drug2 : DB04839 Cyproterone acetate Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01541 Boldenone Drug2 : DB08899 Enzalutamide Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01548 Diprenorphine Drug2 : DB06204 Tapentadol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01565 Dihydromorphine Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000947 Pro-opiomelanocortin (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB01571 3-Methylfentanyl Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01576 Dextroamphetamine Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01576 Dextroamphetamine Drug2 : DB04844 Tetrabenazine Pharmacological target (+,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01576 Dextroamphetamine Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01577 Methamphetamine Drug2 : DB01608 Propericiazine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01577 Methamphetamine Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01579 Phendimetrazine Drug2 : DB04840 Debrisoquin Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01591 Solifenacin Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01608 Propericiazine Drug2 : DB04948 Lofexidine Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01608 Propericiazine Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01615 Aceprometazine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB01616 Alverine Drug2 : DB08810 Cinitapride Pharmacological target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01619 Phenindamine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB01620 Pheniramine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB01622 Thioproperazine Drug2 : DB06262 Droxidopa Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01622 Thioproperazine Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB01622 Thioproperazine Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01622 Thioproperazine Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01625 Isopropamide Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB04837 Clofedanol Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB04839 Cyproterone acetate Drug2 : DB06710 Methyltestosterone Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB04839 Cyproterone acetate Drug2 : DB08804 Nandrolone decanoate Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB04840 Debrisoquin Drug2 : DB04896 Milnacipran Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB04840 Debrisoquin Drug2 : DB06204 Tapentadol Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000770 Mu-type opioid receptor (1) --------------------------------------------------- Drug1 : DB04840 Debrisoquin Drug2 : DB06700 Desvenlafaxine Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB04840 Debrisoquin Drug2 : DB06701 Dexmethylphenidate Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB04840 Debrisoquin Drug2 : DB08918 Levomilnacipran Pharmacological target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB04842 Fluspirilene Drug2 : DB05271 Rotigotine Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000572 Alpha-2B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB04843 Mepenzolate Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB04890 Bepotastine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB04941 Crofelemer Drug2 : DB08820 Ivacaftor Pharmacological target (+,-) : BE0001195 Cystic fibrosis transmembrane conductance regulator Non-common off-target(s) (drug1) : BE0004746 Anoctamin-1 (-1) --------------------------------------------------- Drug1 : DB05271 Rotigotine Drug2 : DB06144 Sertindole Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000572 Alpha-2B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB05271 Rotigotine Drug2 : DB09018 Bromopride Pharmacological target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000572 Alpha-2B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB06204 Tapentadol Drug2 : DB06274 Alvimopan Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB06204 Tapentadol Drug2 : DB06800 Methylnaltrexone Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB06204 Tapentadol Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB06207 Silodosin Drug2 : DB06706 Isometheptene Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB06207 Silodosin Drug2 : DB06707 Levonordefrin Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB06207 Silodosin Drug2 : DB06711 Naphazoline Pharmacological target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB06691 Mepyramine Drug2 : DB06698 Betahistine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB06698 Betahistine Drug2 : DB08799 Antazoline Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB06698 Betahistine Drug2 : DB08800 Chloropyramine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB06698 Betahistine Drug2 : DB08801 Dimetindene Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB06698 Betahistine Drug2 : DB08802 Isothipendyl Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB06698 Betahistine Drug2 : DB08936 Chlorcyclizine Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000968 Histamine H3 receptor (-1) --------------------------------------------------- Drug1 : DB06698 Betahistine Drug2 : DB09016 Butriptyline Pharmacological target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000968 Histamine H3 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB06702 Fesoterodine Drug2 : DB06709 Methacholine Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB06709 Methacholine Drug2 : DB08897 Aclidinium Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB06709 Methacholine Drug2 : DB09076 Umeclidinium Pharmacological target (+,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB06710 Methyltestosterone Drug2 : DB08899 Enzalutamide Pharmacological target (+,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB06738 Ketobemidone Drug2 : DB09049 Naloxegol Pharmacological target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB08804 Nandrolone decanoate Drug2 : DB08899 Enzalutamide Pharmacological target (+,-) : BE0000132 Androgen receptor ---------------------------------------------------