Drug pairs with common pharmacological targets that reduce the overall side effect of 50% for both drugs Drug1 : DB00221 Isoetarine Drug2 : DB00521 Carteolol Pharmacological target (+,+) : BE0000172 Beta-1 adrenergic receptor Common off-target (+,-) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB00921 Buprenorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB01192 Oxymorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB00921 Buprenorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB01192 Oxymorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB00921 Buprenorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB01192 Oxymorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01618 Molindone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB00921 Buprenorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0004899 Kappa-type opioid receptor 2b (1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB00841 Dobutamine Pharmacological target (+,+) : BE0000172 Beta-1 adrenergic receptor Common off-target (+,-) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB00960 Pindolol Pharmacological target (+,+) : BE0000172 Beta-1 adrenergic receptor Common off-target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB01102 Arbutamine Pharmacological target (+,+) : BE0000172 Beta-1 adrenergic receptor Common off-target (+,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB01193 Acebutolol Pharmacological target (+,+) : BE0000172 Beta-1 adrenergic receptor Common off-target (+,-) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00521 Carteolol Drug2 : DB08807 Bopindolol Pharmacological target (+,+) : BE0000172 Beta-1 adrenergic receptor Common off-target (+,-) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00611 Butorphanol Drug2 : DB01548 Diprenorphine Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000420 Delta-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor --------------------------------------------------- Drug1 : DB00611 Butorphanol Drug2 : DB06274 Alvimopan Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00611 Butorphanol Drug2 : DB06800 Methylnaltrexone Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB00813 Fentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB00921 Buprenorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (-,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB01192 Oxymorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB01535 Carfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB01548 Diprenorphine Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB06274 Alvimopan Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB06800 Methylnaltrexone Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00708 Sufentanil Drug2 : DB00921 Buprenorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00708 Sufentanil Drug2 : DB01192 Oxymorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00745 Modafinil Drug2 : DB01255 Lisdexamfetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Common off-target (+,-) : BE0000575 Alpha-1B adrenergic receptor --------------------------------------------------- Drug1 : DB00813 Fentanyl Drug2 : DB00921 Buprenorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00813 Fentanyl Drug2 : DB01192 Oxymorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00813 Fentanyl Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00844 Nalbuphine Drug2 : DB01548 Diprenorphine Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Pharmacological target (-,-) : BE0000420 Delta-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor --------------------------------------------------- Drug1 : DB00844 Nalbuphine Drug2 : DB06800 Methylnaltrexone Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00854 Levorphanol Drug2 : DB00921 Buprenorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00854 Levorphanol Drug2 : DB01192 Oxymorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00854 Levorphanol Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00899 Remifentanil Drug2 : DB00921 Buprenorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00899 Remifentanil Drug2 : DB01192 Oxymorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00899 Remifentanil Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00921 Buprenorphine Drug2 : DB00956 Hydrocodone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00921 Buprenorphine Drug2 : DB01081 Diphenoxylate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00921 Buprenorphine Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00921 Buprenorphine Drug2 : DB01444 Dimethylthiambutene Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00921 Buprenorphine Drug2 : DB01452 Heroin Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00921 Buprenorphine Drug2 : DB01535 Carfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00921 Buprenorphine Drug2 : DB01565 Dihydromorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000947 Pro-opiomelanocortin (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00921 Buprenorphine Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00921 Buprenorphine Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00956 Hydrocodone Drug2 : DB01192 Oxymorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB01081 Diphenoxylate Drug2 : DB01192 Oxymorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB01192 Oxymorphone Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01192 Oxymorphone Drug2 : DB01444 Dimethylthiambutene Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB01192 Oxymorphone Drug2 : DB01452 Heroin Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01192 Oxymorphone Drug2 : DB01535 Carfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01192 Oxymorphone Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01209 Dezocine Drug2 : DB01452 Heroin Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01209 Dezocine Drug2 : DB01535 Carfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) ---------------------------------------------------