Drug pairs with common pharmacological targets that improve of at least 50% the overall side effect for one of the 2 drugs Drug1 : DB00159 Icosapent Drug2 : DB00412 Rosiglitazone Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Common off-target (+,-) : BE0000996 Long-chain-fatty-acid--CoA ligase 4 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000262 Prostaglandin G/H synthase 2 (-1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB00422 Methylphenidate Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Common off-target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB00579 Mazindol Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Common off-target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB00830 Phenmetrazine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Common off-target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB00937 Diethylpropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Common off-target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Common off-target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Common off-target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB06701 Dexmethylphenidate Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Common off-target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00574 Fenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0000393 5-hydroxytryptamine receptor 2B (1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00921 Buprenorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB01192 Oxymorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB00668 Epinephrine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000575 Alpha-1B adrenergic receptor Common off-target (+,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00246 Ziprasidone Drug2 : DB00490 Buspirone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00246 Ziprasidone Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Common off-target (+,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00246 Ziprasidone Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00268 Ropinirole Drug2 : DB09014 Captodiame Pharmacological target (+,+) : BE0000581 D(3) dopamine receptor Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Common off-target (+,-) : BE0000501 Alpha-1A adrenergic receptor Common off-target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB00921 Buprenorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB01192 Oxymorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00334 Olanzapine Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004889 D(1) dopamine receptor (-1) BE0000112 Histamine H2 receptor (-1) BE0000146 Histamine H4 receptor (-1) BE0004688 5-hydroxytryptamine receptor 5A (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00363 Clozapine Drug2 : DB00490 Buspirone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000146 Histamine H4 receptor (-1) --------------------------------------------------- Drug1 : DB00363 Clozapine Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Common off-target (+,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000146 Histamine H4 receptor (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00363 Clozapine Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000146 Histamine H4 receptor (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB01205 Flumazenil Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Common off-target (+,-) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) Non-common off-target(s) (drug2) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 (-1) --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB00574 Fenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000393 5-hydroxytryptamine receptor 2B (1) --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Common off-target (+,-) : BE0000501 Alpha-1A adrenergic receptor Common off-target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB00734 Risperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01224 Quetiapine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01267 Paliperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB04946 Iloperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB06216 Asenapine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) BE0004688 5-hydroxytryptamine receptor 5A (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB01192 Oxymorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0004899 Kappa-type opioid receptor 2b (1) --------------------------------------------------- Drug1 : DB00508 Triflupromazine Drug2 : DB00805 Minaprine Pharmacological target (-,-) : BE0000393 5-hydroxytryptamine receptor 2B Common off-target (+,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Common off-target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB00574 Fenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000393 5-hydroxytryptamine receptor 2B (1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Common off-target (+,-) : BE0000501 Alpha-1A adrenergic receptor Common off-target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00543 Amoxapine Drug2 : DB00574 Fenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Common off-target (+,-) : BE0000393 5-hydroxytryptamine receptor 2B Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0004890 Muscarinic acetylcholine receptor (-1) --------------------------------------------------- Drug1 : DB00543 Amoxapine Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0004890 Muscarinic acetylcholine receptor (-1) --------------------------------------------------- Drug1 : DB00574 Fenfluramine Drug2 : DB00589 Lisuride Pharmacological target (+,+) : BE0000533 5-hydroxytryptamine receptor 2C Common off-target (+,-) : BE0000393 5-hydroxytryptamine receptor 2B Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00574 Fenfluramine Drug2 : DB00726 Trimipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000393 5-hydroxytryptamine receptor 2B (1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00589 Lisuride Drug2 : DB00988 Dopamine Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Pharmacological target (+,+) : BE0000581 D(3) dopamine receptor Pharmacological target (+,+) : BE0000389 D(4) dopamine receptor Common off-target (+,-) : BE0000020 D(1A) dopamine receptor Common off-target (+,-) : BE0000145 D(1B) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00589 Lisuride Drug2 : DB01235 L-DOPA Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Pharmacological target (+,+) : BE0000581 D(3) dopamine receptor Pharmacological target (+,+) : BE0000389 D(4) dopamine receptor Common off-target (+,-) : BE0000020 D(1A) dopamine receptor Common off-target (+,-) : BE0000145 D(1B) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00714 Apomorphine Drug2 : DB09014 Captodiame Pharmacological target (+,+) : BE0000581 D(3) dopamine receptor Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0000666 Neuron-specific vesicular protein calcyon (1) Non-common off-target(s) (drug2) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00726 Trimipramine Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00726 Trimipramine Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Common off-target (+,-) : BE0000501 Alpha-1A adrenergic receptor Common off-target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00734 Risperidone Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00745 Modafinil Drug2 : DB01576 Dextroamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Common off-target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB00875 Flupentixol Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (+,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Common off-target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (+,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB01239 Chlorprothixene Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (-,-) : BE0000393 5-hydroxytryptamine receptor 2B Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (+,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Common off-target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (+,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (+,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) --------------------------------------------------- Drug1 : DB00836 Loperamide Drug2 : DB00921 Buprenorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00836 Loperamide Drug2 : DB01192 Oxymorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00921 Buprenorphine Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,-) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB01454 3,4-Methylenedioxymethamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Common off-target (+,-) : BE0000393 5-hydroxytryptamine receptor 2B Common off-target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01142 Doxepin Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Common off-target (+,-) : BE0000501 Alpha-1A adrenergic receptor Common off-target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB01149 Nefazodone Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01149 Nefazodone Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Common off-target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01186 Pergolide Drug2 : DB09014 Captodiame Pharmacological target (+,+) : BE0000581 D(3) dopamine receptor Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB01191 Dexfenfluramine Drug2 : DB01242 Clomipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug2) : BE0000814 Glutathione S-transferase P (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01192 Oxymorphone Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB01192 Oxymorphone Drug2 : DB01565 Dihydromorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000947 Pro-opiomelanocortin (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB01192 Oxymorphone Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01200 Bromocriptine Drug2 : DB09014 Captodiame Pharmacological target (+,+) : BE0000581 D(3) dopamine receptor Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB01209 Dezocine Drug2 : DB01565 Dihydromorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) BE0000947 Pro-opiomelanocortin (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB01224 Quetiapine Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01267 Paliperidone Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01267 Paliperidone Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB01454 3,4-Methylenedioxymethamphetamine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB01576 Dextroamphetamine Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Common off-target (+,-) : BE0000575 Alpha-1B adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB04946 Iloperidone Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB06216 Asenapine Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000172 Beta-1 adrenergic receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) BE0004688 5-hydroxytryptamine receptor 5A (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB08810 Cinitapride Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) ---------------------------------------------------