"Mutation" "Drug" "P_Raw" "FDR_Raw" "Beta_Raw" "P_PC_Corrected" "FDR_PC_Corrected" "Beta_PC_Corrected" "P_correct_for_65_genes" "FDR_correct_for_65_genes" "beta_correct_for_65_genes" "TP53 MUT" "Nutlin.3a_IC_50" 2.95200641941258e-54 2.62167690108032e-50 2.41979824114707 2.3556109706785e-53 2.09201810305957e-49 2.26435411668203 1.1553316874031e-46 1.02605007158269e-42 2.34201221129414 "BCR_ABL MUT" "Imatinib_IC_50" 2.36507750065335e-30 7.00141776110081e-27 -7.20647335593213 1.877838270912e-30 8.33854084198475e-27 -7.36126183623511 2.00789889862252e-27 4.45803752966666e-24 -7.29328236134297 "BCR_ABL MUT" "GNF.2_IC_50" 9.41585648519033e-24 1.39370369074959e-20 -5.83335298972611 1.92819463110621e-28 5.70809883961809e-25 -6.23258196403343 1.96101318873882e-24 2.90262635486492e-21 -6.02359300979744 "BCR_ABL MUT" "WH.4.023_IC_50" 1.59453474277128e-21 2.02300900722168e-18 -15.7978418972605 7.94188248300585e-27 1.76329645828937e-23 -15.6942972600082 8.43033167203356e-28 2.49565918597767e-24 -16.5491049485497 "BCR_ABL MUT" "Nilotinib_IC_50" 1.66103253388763e-32 7.37581496672802e-29 -9.14416804190488 5.4648940149279e-26 8.78977301004289e-23 -6.88656143355321 5.02198346458703e-29 2.23001175744987e-25 -7.98363505639836 "BCR_ABL MUT" "AP.24534_IC_50" 3.03524232120894e-25 6.73899676366415e-22 -13.7711143425605 5.93836708256473e-26 8.78977301004289e-23 -12.9604069002852 6.3199554660811e-24 8.01821778489518e-21 -12.7861288420718 "BRAF MUT" "PLX4720_IC_50" 2.57383894364766e-24 4.57165273170697e-21 -2.61064676441005 8.78047892609977e-26 1.1139919048956e-22 -2.56151411569845 1.41390750733452e-13 1.56961407157974e-10 -2.09249434263509 "BCR_ABL MUT" "Dasatinib_IC_50" 8.44695345661727e-17 8.33526596091311e-14 -15.4644493493153 5.44035337463551e-25 6.03947229001725e-22 -15.8788122082912 4.09044122468114e-25 7.26544170327864e-22 -16.2728122657452 "BRAF MUT" "SB590885_IC_50" 2.7314729355133e-19 3.03227639253671e-16 -2.36215712710589 1.95907865744356e-19 1.93317528408403e-16 -2.1104688717717 1.07846398631452e-11 1.06420429582881e-08 -1.86068122099786 "RB1 MUT" "PD.0332991_IC_50" 4.77211688330646e-12 3.8528336400586e-09 1.96754173997124 4.76103659709656e-15 4.22827660188145e-12 1.80882524722426 7.11754448133334e-11 6.32109125387214e-08 1.93579082756172 "BCR_ABL MUT" "AZD.0530_IC_50" 1.80947761628981e-07 5.35665690342328e-05 -5.19129487796604 3.9769239530368e-11 3.08382824469164e-08 -5.80467986870712 3.9292147782764e-09 2.90794637048939e-06 -5.54505678503775 "ERBB2 MUT" "Lapatinib_IC_50" 1.98510581004345e-09 9.27880247315573e-07 -5.21707159722223 4.16686622410761e-11 3.08382824469164e-08 -4.9391048441791 5.05544243227892e-08 3.4536449416207e-05 -4.32089231040879 "CDKN2A MUT" "PD.0332991_IC_50" 3.36100082050655e-14 2.98490482869187e-11 -1.32214883115246 5.47474090106368e-10 3.74009030325743e-07 -0.909836548324121 1.62055948571511e-09 1.30838079933054e-06 -1.13262605612748 "EWS_FLI1 MUT" "OSI.906_IC_50" 8.99016202706871e-08 2.85148674865704e-05 -2.81575297591936 4.37653754363215e-09 2.77628785178551e-06 -3.1044445155617 1.49622044741587e-06 0.000927333782151731 -2.91067487912718 "KRAS MUT" "AZD6244_IC_50" 0.000750949709066624 0.0370510242567816 -0.937312628633624 5.97482434789767e-08 3.53749433557861e-05 -1.42016277505647 0.0544780337355186 0.697305726351784 -0.569134867483931 "BRAF MUT" "PD.0325901_IC_50" 1.15931628927668e-11 8.02835695395118e-09 -2.20044110307016 6.91760313936339e-08 3.83970209254289e-05 -1.75463302019576 0.000660224556413134 0.136359401988489 -1.16036786059193 "EWS_FLI1 MUT" "BMS.754807_IC_50" 7.44680156613945e-06 0.00129676558252715 -2.67517390118626 7.89525608524424e-08 4.11741935226154e-05 -2.83972700001619 1.0573623719992e-05 0.00552378542689699 -2.94419397951688 "BCR_ABL MUT" "AZD6482_IC_50" 0.000584674925166011 0.0332380402971253 3.37522180449824 8.34518053605537e-08 4.11741935226154e-05 5.25436137292699 0.000161554669528048 0.0478255673359533 3.679525739527 "BRAF MUT" "RDEA119_IC_50" 1.17519018580526e-11 8.02835695395118e-09 -2.29034047368419 1.21980046576692e-07 5.70160417709264e-05 -1.72455124825364 0.00215948549460144 0.262338505131915 -1.06477251488036 "CDKN2a(p14) MUT" "PD.0332991_IC_50" 1.41987992576122e-10 9.00710972906098e-08 -1.15938676760944 3.0955153688847e-07 0.000137456359955325 -0.776032375950621 1.56626581829478e-06 0.000927333782151731 -0.917474272280979 "CDK6 MUT" "PF.02341066_IC_50" 3.45870065172332e-05 0.0047256493058392 -3.85258740404039 4.03055978195367e-07 0.000170454292493002 -4.34460726850349 0.00559876936119276 0.358956332448686 -3.11377337080046 "FGFR2 MUT" "PD.173074_IC_50" 3.5604873550003e-06 0.000718652004539948 -4.68190248046871 4.26999732135536e-07 0.000172372028231623 -4.37935322869774 0.00233316704157953 0.262338505131915 -4.01009490761225 "BCR_ABL MUT" "PF.02341066_IC_50" 1.27415920042925e-07 3.90200271000419e-05 -4.22551362837843 5.26047238973552e-07 0.000203122849101048 -3.85294796730246 1.68047208231422e-05 0.00710679645858694 -3.45361191937952 "BCR_ABL MUT" "A.770041_IC_50" 5.58289110400296e-05 0.00636696518389764 -5.11689702047777 1.12925800410546e-06 0.000417872513935859 -5.18338240910552 1.22383082106129e-05 0.00580906641412144 -5.33891055203571 "BCR_ABL MUT" "Sunitinib_IC_50" 0.121891452426481 0.580982694522287 -1.83210007876715 1.36106235752099e-06 0.000483503791885758 5.41111427593036 0.652637479881759 0.958313128388245 -0.475348431806671 "PIK3CA MUT" "MK.2206_IC_50" 0.0120619941978534 0.197279135305959 -0.699056157365507 1.5018956795715e-06 0.000513012905010557 -1.06905411278684 0.0965350579150392 0.77097828178369 -0.49666589616601 "APC MUT" "DMOG_IC_50" 5.72658331649563e-07 0.000137453476848102 1.61012367045456 1.70949090787585e-06 0.000562295879735014 1.45063731820691 0.0174520645424557 0.513211661128791 0.88882177667178 "BRAF MUT" "CI.1040_IC_50" 1.2658868379508e-09 6.24574500435614e-07 -1.52028279386218 1.85214597618309e-06 0.00058746101480293 -1.14112632631778 0.00766625896943008 0.389051690900049 -0.711743272823152 "PDGFRA MUT" "AMG.706_IC_50" 0.000165321259489928 0.0138511142031137 -2.1558901886051 5.25476593542367e-06 0.00160922676801716 -2.39087405680389 0.000140161869247317 0.0429233641650145 -2.03800110975827 "ERBB2 MUT" "BIBW2992_IC_50" 1.10336458245357e-05 0.00181462608458707 -2.03663834271598 7.77174407812089e-06 0.00230069530525972 -2.03234355352069 0.000957757091983501 0.160771667262499 -1.51286734997842 "CDKN2a(p14) MUT" "Midostaurin_IC_50" 5.58295637345891e-09 2.25373797966766e-06 -0.927420189578867 9.97778703766786e-06 0.00285847505424285 -0.56193424209534 0.00267773020631848 0.272034735859731 -0.490569512571944 "KRAS MUT" "RDEA119_IC_50" 0.0037067235810061 0.100059003413116 -0.811408371646964 1.39829316518959e-05 0.00385797674409602 -1.13835538738839 0.756665197942224 0.969901216545994 -0.0874469472039591 "EWS_FLI1 MUT" "RDEA119_IC_50" 5.35816688098423e-06 0.0010124655334047 2.8553956406839 1.43354613844352e-05 0.00385797674409602 2.60376867492905 0.0288788883825048 0.597840111247145 1.3728688740732 "MYCN MUT" "NVP.BEZ235_IC_50" 0.00053701542664002 0.0313829878366845 1.18363214807164 1.5557597657771e-05 0.00406373602349011 1.10021251061216 0.0139522899376637 0.482141194305023 0.972489732060307 "MYCN MUT" "OSI.906_IC_50" 6.45617547778103e-05 0.0069081077612257 -1.84065640718131 1.86124411264767e-05 0.00465983312798958 -1.87889005592319 0.000833202061844741 0.15419478704823 -1.79651642107563 "KRAS MUT" "CI.1040_IC_50" 0.0565308178024864 0.428370471760992 -0.401341048467234 1.88890882341656e-05 0.00465983312798958 -0.832569434521384 0.865347321095045 0.987077901072027 0.0367710421729073 "BRAF MUT" "AZD6244_IC_50" 3.81413424253838e-08 1.35493304831934e-05 -1.8795366955536 2.03000602320399e-05 0.00487256310596612 -1.4047607360174 0.013802045378197 0.482141194305023 -0.890360807126917 "KRAS MUT" "PD.0325901_IC_50" 0.0010035717658332 0.0454730655732888 -0.882338719368036 2.16940826663814e-05 0.00507013547789824 -1.11173468270088 0.784764027322756 0.974617441847769 -0.0757474608929769 "PTEN MUT" "AZD6482_IC_50" 1.05585569065736e-05 0.0017720778507382 -0.998666481574371 2.36433410338969e-05 0.0053840131210779 -0.822496331664833 0.00223379646511353 0.262338505131915 -0.739735529854261 "CDKN2a(p14) MUT" "Dasatinib_IC_50" 5.75748871720143e-10 3.19576608109162e-07 -2.91267592375001 2.82503374686222e-05 0.00627228117647084 -1.73794013365665 0.000485504975640164 0.119771380240564 -1.65694615065993 "NRAS MUT" "RDEA119_IC_50" 8.4951281919841e-05 0.00846528803194268 -1.66614501342106 2.95322881691835e-05 0.00639698173732972 -1.63539036725754 4.36781641175997e-06 0.00242441109705252 -1.90599042429466 "BCR_ABL MUT" "Pazopanib_IC_50" 0.739403548483216 0.929570057037101 -0.314467403141367 3.45509410212158e-05 0.00730587874308137 4.06560651234949 0.75577856834548 0.969901216545994 -0.273841029282055 "BRAF MUT" "BIBW2992_IC_50" 0.00499275679720185 0.121149380098223 0.755664091484471 3.8882840867581e-05 0.00803066301732527 1.15123741092562 0.496173071128202 0.933676180352967 0.202567732918551 "MYCN MUT" "Vorinostat_IC_50" 4.12801105786709e-05 0.00539130385366435 -1.23524961991869 4.04536932004969e-05 0.00816521021167302 -0.968682194974553 0.0215545418154849 0.549211893050681 -0.746313578017338 "PTEN MUT" "OSI.906_IC_50" 1.27739257402545e-05 0.00202580775891429 1.03622366499283 4.34185532133279e-05 0.00856889269083478 0.935526678482039 0.000112455222661861 0.0399485932983994 0.998323138672409 "RB1 MUT" "PD.0325901_IC_50" 4.20350952116864e-07 0.000106661051592853 1.64309671978021 5.30124113821435e-05 0.0102348527279308 1.25596520167424 0.00115415756776897 0.179825848409759 1.03375281335147 "BRAF MUT" "Gefitinib_IC_50" 0.00161523038198465 0.0592029235061749 0.72587001208286 5.46170237940562e-05 0.0103202933684045 0.907684932283186 0.422263987712439 0.922428741067589 0.199462873630399 "APC MUT" "PD.0325901_IC_50" 0.00493283000719847 0.120023187106657 -1.20325607062474 7.55156449514758e-05 0.0139719675586262 -1.65418664765717 0.180351753260662 0.848722027112292 -0.626286864758345 "NRAS MUT" "PD.0325901_IC_50" 4.056988303259e-05 0.00537762882406614 -1.67009616769738 7.73292838526679e-05 0.0140155381611335 -1.54674180148233 1.24279092296259e-05 0.00580906641412144 -1.7840788028119 "KDR MUT" "FTI.277_IC_50" 4.67040108274682e-05 0.00577339405687434 -2.5785373644214 0.000101865570525356 0.0180933626367137 -2.24188185320077 0.000238321762523382 0.0622510462638281 -2.23262368408904 "BRAF MUT" "CHIR.99021_IC_50" 3.90627567101016e-05 0.00525630821730928 -0.830145374159046 0.000106260039566539 0.0185038315958908 -0.798608322973074 0.000569072798326074 0.129588090305996 -0.804227252129261 "NRAS MUT" "CI.1040_IC_50" 4.23980800110019e-06 0.000818559453429801 -1.37127354907247 0.000116466684518286 0.0198911658693635 -1.05628821788556 0.00180978928818699 0.238839985796005 -0.936876530418564 "PTEN MUT" "Temsirolimus_IC_50" 3.68510219005418e-06 0.000727275389997138 -1.30242228516886 0.000131549359722259 0.0220432049753468 -0.837357072925023 0.000310771996601695 0.0788561743377044 -1.04994111989204 "PTEN MUT" "Bosutinib_IC_50" 0.08206601133434 0.497724838837149 0.389086286283184 0.000139908832522096 0.0230098211412728 0.716349144941921 0.559850034493006 0.949294892873838 0.131346824848365 "CDKN2A MUT" "Dasatinib_IC_50" 5.1366821850737e-09 2.17232735645903e-06 -2.68535250783762 0.000159354997934391 0.0257314861210059 -1.5222415783281 0.0103858322021507 0.450367315182713 -1.21360067195452 "KDR MUT" "AMG.706_IC_50" 0.00193417519981129 0.0658551428387413 -2.29125424005218 0.000176884173115394 0.0280519346685324 -2.54454154924606 0.0024408143592678 0.262338505131915 -2.08596350478679 "VHL MUT" "WH.4.023_IC_50" 0.000698764071685078 0.0355041590677904 -5.37723217182133 0.000191732413885785 0.0298732555740291 -5.18925598153007 0.234996075370787 0.869962136993019 -2.07490691304625 "NOTCH1 MUT" "Obatoclax.Mesylate_IC_50" 0.000142707504457068 0.0123047121076041 -2.20713080637256 0.000196988647739642 0.0301630375961338 -1.62015832093411 0.00717395885895311 0.381508554648877 -1.65473029854346 "APC MUT" "BMS.754807_IC_50" 0.00164725067965709 0.0594684279920107 -1.33207520719601 0.000219355666015105 0.0330186045742398 -1.35248176657468 0.00709962625120246 0.381508554648877 -1.36152231216479 "BCR_ABL MUT" "AMG.706_IC_50" 0.411081232158356 0.812480994891775 -0.528940764705884 0.00022548421201148 0.0331261315742944 2.71923422144423 0.967848198601905 0.997173634484198 -0.0246848957665392 "NRAS MUT" "AZD6244_IC_50" 2.66370902215192e-05 0.00394273330428853 -1.70554178722526 0.000230860979347239 0.0331261315742944 -1.39392729081874 0.000706524805187627 0.142605608974348 -1.41638299658161 "NOTCH1 MUT" "ABT.263_IC_50" 2.72188659935751e-08 1.00721145370392e-05 -3.22802466657141 0.000231417559956862 0.0331261315742944 -1.99911020675699 0.00304249397237065 0.290541816866922 -1.6435301414481 "PIK3CA MUT" "AKT.inhibitor.VIII_IC_50" 8.37358028237823e-05 0.00845065528270467 -0.893966955176773 0.000234990011167723 0.0331261315742944 -0.722953349767583 0.00264408060766278 0.272034735859731 -0.734313235211359 "APC MUT" "RDEA119_IC_50" 0.045363010139992 0.38006499344648 -0.89349368547108 0.000244954464632737 0.0339912593813021 -1.53655026375166 0.563584532315172 0.949294892873838 -0.274952647073794 "EZH2 MUT" "Metformin_IC_50" 0.000836996726222523 0.0397506306180868 2.15011567877631 0.000250684895633127 0.0342512701248893 2.18388776290498 0.0015541798041548 0.215666731885918 1.99198993442393 "CTNNB1 MUT" "Nutlin.3a_IC_50" 0.000931939146166479 0.0435607976689711 -1.79464844754317 0.000257469058967665 0.034645192616543 -1.8157996305716 0.000619394848939378 0.136359401988489 -1.9675810523908 "CDK6 MUT" "S.Trityl.L.cysteine_IC_50" 0.0183465803803863 0.247999970103821 2.84263512059158 0.00031620793629906 0.0416137792699119 2.34208782747694 0.148651793348173 0.831473272394224 2.17357405469647 "TP53 MUT" "JNK.Inhibitor.VIII_IC_50" 0.0132777950750589 0.207974322383477 -0.259818761791312 0.000318628193936945 0.0416137792699119 -0.376172202610225 0.00240044474459145 0.262338505131915 -0.34471426860728 "MYCN MUT" "ABT.263_IC_50" 4.44366401913047e-05 0.00563774002198538 -1.96330216932287 0.000339128166671855 0.0425974663355701 -1.59624918941284 0.685548525759476 0.961100601384891 -0.2069367402295 "EWS_FLI1 MUT" "Gemcitabine_IC_50" 0.00044732328513577 0.0275880423284081 -3.70228951245556 0.000339960660261149 0.0425974663355701 -2.69059457500599 0.556773424436714 0.948995333915792 -0.666436042052011 "APC MUT" "JNJ.26854165_IC_50" 7.15933913958249e-08 2.35489225550489e-05 1.17856933333334 0.000340549500036648 0.0425974663355701 0.777301665010732 0.0012785039329463 0.192447346245696 0.817717014670043 "KIT MUT" "AMG.706_IC_50" 0.00262777050689982 0.0792783302091417 -1.92785727450981 0.000360293982275126 0.0442447036575882 -2.10354575321494 0.00236097114726238 0.262338505131915 -1.80962359062909 "EWS_FLI1 MUT" "AZD6244_IC_50" 0.000581370587482512 0.0332380402971253 2.07742548716399 0.000366816966043387 0.0442447036575882 2.06729135286568 0.0194905371889104 0.524531699317313 1.47474429476189 "MLL_AFF1 MUT" "CHIR.99021_IC_50" 0.000673784938562014 0.0351701883538398 -3.4382717586207 0.000370119458175262 0.0442447036575882 -3.46424223208174 0.000118752273292185 0.0405630361195346 -3.77165438328103 "NF1 MUT" "AZD8055_IC_50" 0.000436393990791082 0.0274186162288596 1.08169839044049 0.000373646298200553 0.0442447036575882 0.857305232023663 0.0206131366550025 0.537895789994757 0.751459562535988 "RB1 MUT" "BI.D1870_IC_50" 0.00191178056848857 0.0656214899931353 -0.702780602289967 0.000389090677320563 0.0454672934905779 -0.709492784878735 0.00565276368018946 0.358956332448686 -0.659736791704611 "FGFR2 MUT" "Doxorubicin_IC_50" 5.46261205660585e-08 1.86590221825833e-05 5.25057507329848 0.000413192282922331 0.0476566320082237 2.17052753504856 0.000103896798889973 0.0384461446225773 4.13664269186081 "MET MUT" "PHA.665752_IC_50" 0.0011979455796179 0.0504215862207894 -3.12192506711406 0.000430235898117526 0.0484175650487013 -3.34987410951627 0.00661914409819726 0.370691368090687 -2.68666749358269 "EWS_FLI1 MUT" "X17.AAG_IC_50" 0.000276267370997609 0.0198775318300914 2.14862621832361 0.000430693349718208 0.0484175650487013 1.95386294843917 0.0112559000677066 0.450437967177441 1.52920816240929 "RB1 MUT" "VX.702_IC_50" 0.000188913349788125 0.015204607912249 -0.779586263045672 0.000469652446835239 0.0517326330493993 -0.603225854324503 7.20675836767091e-05 0.0278274874188197 -0.853136884335897 "CDH1 MUT" "X681640_IC_50" 0.00043124702191578 0.0273564628688146 2.03363371560572 0.000471832369890929 0.0517326330493993 1.74981928686597 0.00585187552711753 0.363430115778537 1.61095019184264 "EWS_FLI1 MUT" "MG.132_IC_50" 0.231026993472207 0.703760072600075 -0.869003551472908 0.000486818722400747 0.0521875653318632 -2.4074654890797 0.0327614682700112 0.618827479917328 -1.64849213192813 "STK11 MUT" "Camptothecin_IC_50" 0.00524910923817087 0.12435456197272 1.36095687789133 0.000487734255437974 0.0521875653318632 1.07287770254118 0.0341529567549314 0.618827479917328 0.975222611598844 "SMAD4 MUT" "JW.7.52.1_IC_50" 0.634180161363825 0.89399270048764 -0.489550679802954 0.000521345865772916 0.0544920488269118 2.19391014694052 0.931900933804979 0.994235539701634 -0.094413987798594 "BCR_ABL MUT" "BMS.536924_IC_50" 0.851425602601536 0.963639744191413 -0.233056051194537 0.000521543086396521 0.0544920488269118 4.06828550385029 0.919827949634071 0.993794649720217 0.120845169577388 "ALK MUT" "PF.02341066_IC_50" 0.0158010836091032 0.22780750573449 -1.96637148310812 0.000533234865570599 0.05501054263112 -2.61860063349166 0.000850753807607618 0.15419478704823 -3.09625292474064 "TP53 MUT" "AG.014699_IC_50" 0.00999340755190258 0.177502904936894 0.370094848802497 0.000550388361461513 0.05501054263112 0.459497986339145 0.0189246767584603 0.516564999115032 0.336402643821347 "MET MUT" "PF.02341066_IC_50" 0.00604046785522674 0.135468169248153 -3.14836731208051 0.000550695286201441 0.05501054263112 -3.62370830744155 0.00559876936119276 0.358956332448686 -3.11377337080046 "CDKN2A MUT" "Midostaurin_IC_50" 5.03543108812573e-07 0.000124221287482346 -0.778138674083727 0.000551282321154113 0.05501054263112 -0.429934809866162 0.0772808414454556 0.741811190933953 -0.287746108456427 "MYCN MUT" "BMS.754807_IC_50" 0.0400139139816776 0.361141839503332 -1.0739902854578 0.00056360541384068 0.0556153297813231 -1.51393403277031 0.0104742412315163 0.450367315182713 -1.52122836222334 "MYCN MUT" "AZD8055_IC_50" 0.0133433821532725 0.208631297364812 0.780560325102889 0.000584039641100843 0.0569984181606218 0.873182523539502 0.0830752495348213 0.745860856369627 0.643691729384223 "PDGFRA MUT" "FTI.277_IC_50" 0.000251494303422877 0.0186126742391548 -1.80136961871749 0.000596944244831814 0.0576245851994711 -1.53871889283861 0.00236364937250414 0.262338505131915 -1.44405723942126 "CCND1 MUT" "Gefitinib_IC_50" 0.0650487108521662 0.457401109325485 -0.61280817055556 0.000616366377490456 0.0588596752526101 -1.02205274517986 0.291150700818085 0.891022884087089 -0.341105558451906 "TP53 MUT" "Docetaxel_IC_50" 0.0178295666369999 0.245008564936728 -0.396892297388878 0.000673857266023799 0.0636651742506102 -0.440157634803782 0.0146223082628721 0.490024700267999 -0.424018962684112 "CCND1 MUT" "BIBW2992_IC_50" 0.00760124684047499 0.153207816483996 -1.03382058769842 0.000711308514429475 0.0664961149120859 -1.25739949093896 0.244736349373525 0.875707386589409 -0.450057409473718 "TP53 MUT" "Gefitinib_IC_50" 0.0768521824659233 0.485436865206163 -0.264313343525294 0.000786540214737858 0.0719386648971232 -0.467805428061238 0.0776557738577269 0.741811190933953 -0.255153989567794 "CDKN2C MUT" "AZD.2281_IC_50" 0.096300195914391 0.530089096130627 -0.886237440239047 0.000788262003360686 0.0719386648971232 -1.35018691320665 0.0963927863757696 0.77097828178369 -0.834302724667795 "EZH2 MUT" "CGP.082996_IC_50" 0.0782119972746568 0.486980385654137 -1.44641441780822 0.000793828303109793 0.0719386648971232 -2.29423797586815 0.156199727745518 0.837288218996252 -1.3215995005726 "BCR_ABL MUT" "Nutlin.3a_IC_50" 0.579715728215491 0.874695104023408 -0.518619321568627 0.000820549308359958 0.0736090748236847 3.5063867322248 0.400015046956303 0.916480913435499 0.7871778839148 "PTEN MUT" "SB590885_IC_50" 0.0536271558863783 0.413543213551623 -0.46347365433404 0.000843479704741373 0.0749094325780814 -0.684004870716838 0.0189615464904563 0.516564999115032 -0.535807290965563 "PTEN MUT" "X17.AAG_IC_50" 0.00380850752965039 0.101571637750225 -0.793165273462206 0.000870170507474252 0.0765146958106815 -0.818575235863136 0.0191458893502731 0.519983618714908 -0.615384908412922 "MAP2K4 MUT" "ABT.263_IC_50" 0.042733047118326 0.372070775939072 -1.2851417805445 0.000926298543713264 0.0806515428109558 -1.88556149097861 0.000811332132268469 0.15419478704823 -2.03259883070408 "APC MUT" "AZD6244_IC_50" 0.120396882629202 0.578908887184593 -0.688160155475042 0.000935677943450206 0.0806772409299154 -1.37786682648502 0.715063172560172 0.962630898212352 -0.178529994811424 "CCND1 MUT" "Lapatinib_IC_50" 0.00157488872625003 0.0582774449076104 -1.79610065957447 0.000951441969857178 0.0812476551375154 -1.64633730984632 0.0439373235237533 0.659657620288543 -1.19594204644044 "NOTCH1 MUT" "ZM.447439_IC_50" 1.77266469557266e-06 0.000383976467350751 -2.04630941914285 0.000972950838325573 0.0821238958585027 -1.17153342661011 0.00287307774086417 0.278978425995064 -1.32220229184672 "VHL MUT" "TW.37_IC_50" 0.0104712430282554 0.181986515330599 1.31108997278913 0.000980197383290315 0.0821238958585027 1.52835042144282 0.000630103840509759 0.136359401988489 1.69392033133068 "KDM5C MUT" "LFM.A13_IC_50" 0.000816399357322865 0.039404579849915 1.84838800174523 0.00100971770047153 0.0822472010873563 1.71409958922761 0.00123196617944839 0.188639511028986 1.77004052952881 "APC MUT" "AKT.inhibitor.VIII_IC_50" 0.11487285128278 0.567167686753817 -0.458639843863641 0.00101223379761015 0.0822472010873563 -0.856735166463962 0.681745217059343 0.961100601384891 -0.142440865096146 "RB1 MUT" "CI.1040_IC_50" 0.000537125791146948 0.0313829878366845 0.856761635794276 0.00101690143639499 0.0822472010873563 0.73488958877509 0.349701195861051 0.909999728614578 0.226983701756825 "EWS_FLI1 MUT" "NSC.87877_IC_50" 0.00292964660648125 0.0851452377513044 -0.867895908289233 0.00101987852368488 0.0822472010873563 -1.010395421447 0.000740925937211714 0.146225849963938 -1.13739590199863 "TET2 MUT" "Bicalutamide_IC_50" 0.0476209945036764 0.386936918743962 -0.710042311265962 0.00102797425072588 0.0822472010873563 -1.13078342077137 0.0451823555009761 0.666726767128739 -0.824308902780267 "CDH1 MUT" "PHA.665752_IC_50" 0.00173097245834389 0.0612460812850682 -1.9203480338983 0.00105299647152849 0.0826920585509319 -2.0397090577357 0.00145631192643258 0.205968687037918 -2.04423021672267 "CDKN2a(p14) MUT" "WH.4.023_IC_50" 2.3194230837413e-07 6.43712387709579e-05 -2.22938000166667 0.00105744481507602 0.0826920585509319 -1.3103303066318 0.000841994353699504 0.15419478704823 -1.5466881259693 "APC MUT" "AUY922_IC_50" 0.0903231471221723 0.515195805775217 0.591404882606634 0.00106146770350256 0.0826920585509319 0.797419678032393 0.20497774450118 0.853446327418758 0.515050961305537 "STK11 MUT" "X17.AAG_IC_50" 0.00400711951098421 0.103752852411227 -1.34140616157695 0.00109399733484408 0.0844031762759266 -1.33162569928573 0.276270956567035 0.884207634152307 -0.477391298191349 "BRAF MUT" "AZ628_IC_50" 3.94973672893709e-10 2.33850745931269e-07 -3.87343521774654 0.00110243986578172 0.0844031762759266 -1.6639605123905 0.0120514944261254 0.459749370120074 -1.78736805654929 "CDKN2A MUT" "Vorinostat_IC_50" 0.75828717055146 0.934762260113025 0.0346134195466367 0.00111291681539477 0.0844770447651364 0.290538477297339 0.886814569632287 0.988301482344111 -0.0165358940520702 "STK11 MUT" "GW.441756_IC_50" 0.00606460589998806 0.135471782539943 -0.724371636901556 0.00117976837197091 0.0887925670463868 -0.838809239299948 0.0438321981970679 0.659657620288543 -0.56458936504772 "EWS_FLI1 MUT" "CI.1040_IC_50" 0.0207706650084407 0.261651455233988 1.11715924469866 0.00125664689910567 0.0937838748819956 1.46741656473327 0.201642602672012 0.851539683466542 0.629154008710347 "BRAF MUT" "ZM.447439_IC_50" 0.080518150945599 0.492819916297632 0.401203539694045 0.001304515819114 0.0965450415795956 0.64462199070343 0.213314005468404 0.858767761815455 0.325037121625783 "BRCA1 MUT" "Thapsigargin_IC_50" 0.120282005434405 0.578669821377548 -2.2407691431065 0.00132854035119311 0.0975104699086446 -3.54050192438323 0.0927978047951223 0.768046723169691 -2.37239764390005 "KDM6A MUT" "BIBW2992_IC_50" 0.000989543494782336 0.0450673629598048 -1.57763472222221 0.00134451363609961 0.097873980345907 -1.47467399724614 0.0426017644898278 0.658180729724545 -0.930948199427722 "EWS_FLI1 MUT" "AG.014699_IC_50" 2.58174870972817e-09 1.14642551455479e-06 -2.36354795702921 0.00139246777300358 0.0999790301613851 -1.2608872112913 0.148475151899268 0.831473272394224 -0.700783426244558 "ALK MUT" "X17.AAG_IC_50" 0.0106226372137432 0.183539522152152 3.23678770038173 0.0013959463731575 0.0999790301613851 3.55527599366542 0.503217449728033 0.934042323734638 0.919013706674194 "CDK6 MUT" "QS11_IC_50" 0.0113539447625714 0.189538314730069 1.76274077855888 0.00144279736572866 0.10250786724029 1.6290545548828 0.0324556083711069 0.618827479917328 1.55515160854879 "MSH6 MUT" "Obatoclax.Mesylate_IC_50" 0.00678093272949637 0.142704889977861 -2.2130571318102 0.00148542376059219 0.10469879696682 -1.90168826900307 0.00471525915116389 0.349220649476767 -2.20059144242873 "FGFR2 MUT" "JNJ.26854165_IC_50" 0.00105074554067247 0.0473009282089722 2.62944017937215 0.00153195352947867 0.107128183427559 2.40297037964288 0.0598331140464453 0.70215997387469 2.0242684594544 "ALK MUT" "PLX4720_IC_50" 0.0340736494444114 0.341159053794609 2.31452995785441 0.00156141048614585 0.108148628134083 3.06069528135615 0.0940301380927823 0.768683143653123 2.0420022136844 "KIT MUT" "Sunitinib_IC_50" 0.00791872411703724 0.156679237330372 -4.41523715306124 0.00157090114055813 0.108148628134083 -3.97366615623025 0.00545861151766465 0.358956332448686 -4.06637621323394 "MSH6 MUT" "VX.702_IC_50" 6.57076169789071e-05 0.0069470160284485 -2.25868568951278 0.0015922630211427 0.108776060698218 -1.46444350142504 0.000137347361315236 0.0429233641650145 -1.99588256616231 "MYCN MUT" "SB.216763_IC_50" 0.000597960776662984 0.0332380402971253 -1.16107163730899 0.00168190977453792 0.114023211508941 -1.05701604885434 0.000232475040820876 0.0622510462638281 -1.41174182536288 "KRAS MUT" "PLX4720_IC_50" 0.00360692764197355 0.0977698296213311 0.646201385760454 0.00169476063274415 0.114024008934854 0.657066173058788 0.0176125584109927 0.513211661128791 0.555804838946623 "NF2 MUT" "Pyrimethamine_IC_50" 0.010095726673432 0.178250792418986 1.91328484320558 0.00171553652027231 0.114345225616401 2.02603766575047 0.0667349234438996 0.714925036315166 1.50736543303311 "CDKN2A MUT" "LFM.A13_IC_50" 0.000374850316345724 0.0248436243243759 -0.329192570236779 0.00173606952397921 0.114345225616401 -0.283425180833129 0.0471337669145546 0.673636396626734 -0.210089800463018 "TP53 MUT" "BIBW2992_IC_50" 0.0901406140705724 0.514691890245822 -0.295756787220723 0.00173816073169848 0.114345225616401 -0.54333594206081 0.357420290407802 0.91161229252998 -0.1595540273968 "MYC MUT" "DMOG_IC_50" 0.000681147663197888 0.0351701883538398 0.948683651571484 0.001798908117162 0.117471345503792 0.789715976513659 0.0178028088928348 0.513211661128791 0.66122786625926 "HRAS MUT" "JNK.9L_IC_50" 0.00483076405154159 0.118938844209653 1.73257372097052 0.00184494251295129 0.119598061733725 1.50054644060067 0.00160724088187098 0.219598558029172 1.92257279814219 "CDK4 MUT" "AS601245_IC_50" 0.105486786003744 0.549178497675936 1.03702971968366 0.00187445098849449 0.120630429194345 1.59757485872868 0.0290471885191393 0.59799127175549 1.46542527189318 "EWS_FLI1 MUT" "AZD.2281_IC_50" 1.90501208971474e-08 7.35583146467679e-06 -2.24579201180879 0.00201431143606381 0.128449804133413 -1.00962398595339 0.00465605917729145 0.349220649476767 -1.16245294878804 "CCND1 MUT" "SB.216763_IC_50" 0.00146382243715302 0.0562779526595497 0.963236247454182 0.00202488149743023 0.128449804133413 0.911659176983915 0.0167939648434807 0.513211661128791 0.758097208758979 "TP53 MUT" "Thapsigargin_IC_50" 0.0460953174795369 0.382890359661179 -0.504268194093166 0.00205339321020842 0.128819688749646 -0.612291032779827 0.0211881961437377 0.544537742310648 -0.610680598979191 "CDH1 MUT" "TW.37_IC_50" 0.0340159472754711 0.340965719812031 -1.08699583219956 0.00205972253152232 0.128819688749646 -1.44057909143686 0.00425517214580831 0.343606196353575 -1.53021544402178 "MYCL1 MUT" "KIN001.135_IC_50" 0.00562702468614423 0.129130765471956 -0.881705460750858 0.00221851761162022 0.137780803558036 -0.963512329098034 0.00106728786576183 0.169260420282694 -1.01095344879258 "TSC1 MUT" "MK.2206_IC_50" 0.041974448543176 0.368354819675836 2.56744181855664 0.00235089720588662 0.144988320038049 3.06704821814899 0.00520399189493285 0.358956332448686 3.42714454097426 "NF2 MUT" "Z.LLNle.CHO_IC_50" 0.00150558248984815 0.0569603689624804 -1.83782167482517 0.00240822900098155 0.147499874191153 -1.66529026700345 0.00785552663036137 0.393484070559031 -1.64480399168833 "EWS_FLI1 MUT" "Mitomycin.C_IC_50" 5.18547828068606e-05 0.00620421400982985 -2.32969494128116 0.00257813599684108 0.156824834164011 -1.44881929510061 0.0513883082618903 0.689395114310948 -1.25195452085455 "NOTCH1 MUT" "Temsirolimus_IC_50" 0.832106679302058 0.958611936552287 0.13096134895978 0.00264845337059688 0.160006220301162 1.47383829861511 0.00983239466302651 0.441633528381952 1.63890295240093 "PIK3CA MUT" "GDC0941_IC_50" 0.171815604120235 0.649869838241826 -0.380393105660927 0.00275448895344391 0.164671048554606 -0.67616163495308 0.0774967833869283 0.741811190933953 -0.533559470349431 "NOTCH1 MUT" "AZD7762_IC_50" 0.000152335759659647 0.013008595014782 -1.82120061389587 0.0027627503923698 0.164671048554606 -1.170015758145 0.114490670654928 0.799692247086917 -0.754730103497133 "MLLT3 MUT" "PD.0325901_IC_50" 0.017094441459616 0.240174702440681 -1.31805112148858 0.00288302453404763 0.17069427257918 -1.54320712775511 0.216079609416633 0.860576337437605 -0.632491590226901 "MYCN MUT" "NU.7441_IC_50" 0.00199096005116498 0.0662499796990626 -0.981144428766582 0.002970966905393 0.17473613964765 -0.860055292949197 0.00790969092572868 0.393484070559031 -1.00725589196374 "CCND1 MUT" "GDC.0449_IC_50" 0.00373963393026366 0.100641481620217 0.723301959595962 0.00299362683729153 0.174910525934119 0.665144085984771 0.0137349129417378 0.482141194305023 0.657684495038003 "MLH1 MUT" "NVP.BEZ235_IC_50" 0.0722593358174226 0.474889173046706 0.884550995959596 0.00301936026148157 0.175261035831489 1.06987678376523 0.0241553793434865 0.569786836641336 1.06558176600919 "SMARCA4 MUT" "PF.4708671_IC_50" 0.00263338671452503 0.0792783302091417 -1.12448641552511 0.00310593472004869 0.179115624991899 -1.08278544240637 0.0183801348121794 0.513871228544795 -1.0242152284415 "NOTCH1 MUT" "ATRA_IC_50" 8.02204153995851e-10 4.19080887743362e-07 -2.82031732421876 0.00312809534934578 0.179229772887354 -1.12623583198654 0.00146109979544971 0.205968687037918 -1.41230655381292 "MYCN MUT" "AS601245_IC_50" 0.00108007592229421 0.0477221605268402 1.33388414362656 0.00323168208647998 0.183978003910441 0.985219633189331 0.149060737527732 0.831473272394224 0.677739558931451 "MDM2 MUT" "AS601245_IC_50" 0.00947445321650215 0.171369896162435 1.48652193650793 0.00325396848055495 0.184066841247188 1.34667039619686 0.00385715749033916 0.323164298789642 1.62948893765113 "CDKN2A MUT" "WH.4.023_IC_50" 1.2081222978322e-06 0.000268233353176193 -2.04439090570144 0.00330951494232094 0.186024064574382 -1.14038720214101 0.00793082407725104 0.393484070559031 -1.22453396781486 "SMARCA4 MUT" "S.Trityl.L.cysteine_IC_50" 0.170192694516181 0.649721929411943 -1.65828228555175 0.00347097142594775 0.193872309646805 -1.91789183468999 0.0963205320628654 0.77097828178369 -3.50917018416572 "EWS_FLI1 MUT" "Nutlin.3a_IC_50" 0.0957703166317791 0.529259917882996 0.841082634857139 0.00361368671994304 0.199505050483295 1.44548069673953 0.00677122192943633 0.375845137220775 1.53269487820183 "NOTCH1 MUT" "Elesclomol_IC_50" 0.0111864515428713 0.187804952756533 1.49219340166438 0.0036167450881444 0.199505050483295 1.46261926989176 0.05534179325018 0.697813103075383 1.15820728749951 "CDKN2a(p14) MUT" "LFM.A13_IC_50" 0.000419971106636801 0.0268328302017369 -0.336770253296773 0.00369042445521599 0.201232474184625 -0.2694929083128 0.0403820053732305 0.652059254035745 -0.218171566573565 "BRAF MUT" "WZ.1.84_IC_50" 0.131850243619872 0.596996700655848 0.570494722077924 0.00369337836866276 0.201232474184625 0.991623133191597 0.0738602738262055 0.741621865836141 0.828214768205763 "TP53 MUT" "Bleomycin_IC_50" 0.0190759896380026 0.251111880766628 0.678819016431736 0.00375266493988415 0.201301593493327 0.703460201443064 0.0327416026888721 0.618827479917328 0.64325094079643 "MLLT3 MUT" "CI.1040_IC_50" 0.0184262452593747 0.248320916765564 -0.982260472230869 0.00376143021341192 0.201301593493327 -1.07709386704066 0.111222622888497 0.797376436030023 -0.614078122293402 "NOTCH1 MUT" "GSK269962A_IC_50" 0.0169263320939201 0.239099918343183 -1.61924740350878 0.00377272814887988 0.201301593493327 -1.92244310475639 0.00868656144695055 0.410347618140255 -2.03776011072652 "RB1 MUT" "Nutlin.3a_IC_50" 0.000285021694616071 0.0202502213590826 0.967706347987127 0.00378531315317932 0.201301593493327 0.726058016612226 0.000186568024937707 0.0517784571709931 1.06831846111667 "BRCA1 MUT" "Bleomycin_IC_50" 0.102660850776102 0.543667868659847 -2.69779100218154 0.00382300562135998 0.202095910257726 -3.8948227511814 0.0274482778924523 0.588860092297546 -3.53356743892468 "TP53 MUT" "EHT.1864_IC_50" 0.0198228280154921 0.254402508100556 0.29329394006512 0.00390325482114533 0.205117195660306 0.380721558554712 0.0431676708174285 0.658180729724545 0.267696716238275 "APC MUT" "CI.1040_IC_50" 0.665231864351844 0.904120604106079 -0.145464859005375 0.00395158648764581 0.206435527039897 -0.894146166714362 0.807223607754276 0.977383317127464 0.0880604320167658 "NOTCH1 MUT" "Cytarabine_IC_50" 0.00884296657520819 0.165335549798787 -1.40240788821084 0.00398736406256284 0.206675124770733 -1.23333232671813 0.189037368616839 0.851001889249827 -0.709335960131094 "BRAF MUT" "DMOG_IC_50" 0.0395167039502981 0.361141839503332 0.521220355356216 0.00401024181191102 0.206675124770733 0.719345650913758 0.0297328028552353 0.59799127175549 0.620793720670844 "EP300 MUT" "AZD8055_IC_50" 0.0644562529553129 0.455761132560616 1.51738805158727 0.00402598767991632 0.206675124770733 1.8408442782426 0.0621198150711147 0.702860976445846 1.47178482322233 "SMAD4 MUT" "Doxorubicin_IC_50" 0.0413632680012506 0.367141466987459 -0.756585540964014 0.00408799790214775 0.208109940663123 -0.680053003724789 0.0162887729089955 0.511430874476493 -0.909977948375167 "NOTCH1 MUT" "CEP.701_IC_50" 0.0017985996269707 0.0626406403416737 -1.55416193314843 0.00410080392028448 0.208109940663123 -1.08907207262496 0.349952681564887 0.910234471297282 -0.460477334489469 "RUNX1 MUT" "Vorinostat_IC_50" 0.0657318027043093 0.457742485196035 1.34661619723867 0.00419167895293469 0.211218000142207 1.58956158974935 0.055047094423292 0.697305726351784 1.26871314467569 "MYCN MUT" "Metformin_IC_50" 0.00534373793289276 0.124888780479002 0.958531960784316 0.00420961446066555 0.211218000142207 0.942829238892175 0.00624909147861978 0.369987876144149 1.0837875655153 "CDK6 MUT" "PHA.665752_IC_50" 0.0100354757234892 0.177539959960772 -2.03592144781144 0.00426749436958427 0.212919199417292 -2.25808475815789 0.00661914409819726 0.370691368090687 -2.68666749358269 "HRAS MUT" "FTI.277_IC_50" 0.00386125549786795 0.102363612168852 -1.42484688734834 0.00436502849879807 0.21656881618897 -1.28615208876751 0.0427357740766515 0.658180729724545 -0.950788779105351 "APC MUT" "Cytarabine_IC_50" 0.148218224736328 0.62208225608853 0.530482856328539 0.00441649917632654 0.217842667767246 -0.83021900904986 0.817976529023464 0.977383317127464 -0.0961576956800313 "VHL MUT" "Dasatinib_IC_50" 0.00824901642039723 0.159584363220549 -4.63123054982821 0.00444434630456568 0.217842667767246 -4.1514739442228 0.609872204497706 0.949930222127033 -0.9159755226263 "STK11 MUT" "KU.55933_IC_50" 0.0406360543486786 0.364166295328572 -0.547198890678113 0.00446429068051331 0.217842667767246 -0.67467269154449 0.0590988145248535 0.70215997387469 -0.531171219284091 "MLH1 MUT" "GDC.0449_IC_50" 0.00125749030649537 0.0516237563356707 -1.19514313806035 0.00456436687896691 0.219827002130248 -0.948709595570939 0.0105641799765967 0.450367315182713 -0.950065841563232 "MLLT3 MUT" "DMOG_IC_50" 0.00610033281772451 0.135517083280976 -1.06341551948051 0.0045743918902323 0.219827002130248 -0.984118163453315 0.0331203763601133 0.618827479917328 -0.813263205281032 "MYCL1 MUT" "CI.1040_IC_50" 0.00254407585038776 0.0777226391106888 1.91443252702701 0.00459356295612361 0.219827002130248 1.60184121115709 0.0281377660458988 0.594003885301891 1.34753258416279 "CDKN2A MUT" "MG.132_IC_50" 6.41282711806627e-05 0.0069081077612257 -1.13072181041204 0.00460396603943544 0.219827002130248 -0.759755098980046 0.115429133983504 0.802355750183445 -0.484331916735177 "MSH2 MUT" "PAC.1_IC_50" 0.00152646861987055 0.0569603689624804 -2.07148360701757 0.00469338381121173 0.222292806078126 -1.5595074249741 0.0166129094838046 0.513211661128791 -1.5262391670637 "CDH1 MUT" "JW.7.52.1_IC_50" 0.0893729326501254 0.514272513671442 -2.05607275342465 0.00470566912990516 0.222292806078126 -2.11251077279598 0.272562737055146 0.881832301561657 -1.38421910295593 "ERBB2 MUT" "KU.55933_IC_50" 0.00528212490109919 0.124415842357912 0.885944333164306 0.00475977039612416 0.223658840677136 0.82305906843312 0.0175467173994194 0.513211661128791 0.791974396298439 "NOTCH1 MUT" "BIRB.0796_IC_50" 0.253143386248908 0.717874556377469 0.376174686716797 0.00482521074655223 0.224421577388044 0.925697224340234 0.0565258611048721 0.697813103075383 0.675674838393454 "RB1 MUT" "AUY922_IC_50" 0.00622782346038427 0.13690420829622 0.675330366275279 0.00482654220032839 0.224421577388044 0.478395631414437 0.636329288962309 0.953101495776253 0.126988228642014 "CDH1 MUT" "Lapatinib_IC_50" 0.00389657696673896 0.102686943743646 -2.30275815331011 0.00492838148443293 0.227354562644077 -1.95911614952445 0.0718196060861306 0.733981497872182 -1.29922066400932 "EWS_FLI1 MUT" "PD.0325901_IC_50" 0.00197322034754094 0.0662499796990626 1.87524226195308 0.00496134786141717 0.227354562644077 1.69301999964686 0.305547197157974 0.896453471410625 0.633941047005049 "TP53 MUT" "Cyclopamine_IC_50" 0.0573206504388783 0.430077283009252 0.341718299595142 0.00496642102836965 0.227354562644077 0.483535698452672 0.0992239664259161 0.774133667469059 0.323855843658329 "TP53 MUT" "Nilotinib_IC_50" 0.7765453238082 0.941591338606299 -0.0428485245570114 0.00511510660018656 0.232960316493625 -0.361050347934175 0.0495428367654574 0.679896345274018 -0.285953746160111 "SETD2 MUT" "CHIR.99021_IC_50" 0.00110164243901797 0.0479592475535227 -3.30119068965524 0.00515501038326062 0.233579832723151 -2.69768092945188 0.00819935874808637 0.397959104863583 -2.58633232689063 "PTEN MUT" "AUY922_IC_50" 0.193740652418844 0.668979131185171 -0.288844931252989 0.005237972464189 0.236134179971891 -0.425428985749639 0.0618314065312545 0.702860976445846 -0.428992029010925 "FBXW7 MUT" "BIRB.0796_IC_50" 0.0319460992123209 0.329263246012996 0.554939302967566 0.00546156848085863 0.244222430476193 0.688750176071123 0.0351271820527163 0.622683640339667 0.572522806061602 "CDKN2a(p14) MUT" "AP.24534_IC_50" 3.22442152713723e-05 0.00447438868476652 -0.986821760945132 0.0054723864052204 0.244222430476193 -0.614713274967248 0.0112596811973192 0.450437967177441 -0.635278216911533 "TP53 MUT" "BIRB.0796_IC_50" 0.266330909594022 0.729152786837712 -0.124418075721966 0.00562505834386555 0.248989357581169 -0.309513292138576 0.242374083786987 0.875707386589409 -0.139319473413948 "ALK MUT" "Bosutinib_IC_50" 0.138591880902528 0.606920362078576 1.88381748761907 0.00563527315322767 0.248989357581169 2.91659971297619 0.224533284033161 0.86643108387559 1.43863916794726 "IDH1 MUT" "BX.795_IC_50" 0.221470133677224 0.694028319402763 1.38287790283399 0.00567751868280271 0.24961407634639 2.39215764228347 0.0484405622329518 0.676839988046433 1.97608056236472 "SETD2 MUT" "FH535_IC_50" 0.0146570378580482 0.219880326380618 2.74154618608699 0.00577877014749454 0.251599251875297 2.67136196697732 0.00536258162273079 0.358956332448686 2.99307790170158 "BCR_ABL MUT" "A.443654_IC_50" 0.644921580717962 0.896610607131532 -0.470398650684939 0.00577933198767713 0.251599251875297 2.31043145018303 0.749988751523744 0.968780465757047 -0.338232307970479 "BRAF MUT" "Metformin_IC_50" 0.000597224359760268 0.0332380402971253 0.70038008456659 0.00584778218555004 0.252548558412676 0.575617345713597 0.0134606784223147 0.482141194305023 0.591164099081313 "BCR_ABL MUT" "FH535_IC_50" 0.00592484898228457 0.13354970510576 2.18798644328101 0.00585801182670997 0.252548558412676 2.24967796240599 0.00555975227368987 0.358956332448686 2.15100383337041 "PIK3CA MUT" "X17.AAG_IC_50" 0.0498504743897351 0.397773641559063 -0.638723376939211 0.0060149858113176 0.256600324448559 -0.793538949800276 0.450185573865764 0.925809648901546 -0.239104635363491 "RB1 MUT" "SB.216763_IC_50" 0.00482665892380344 0.118938844209653 -0.582923436758892 0.00602949254364577 0.256600324448559 -0.565875426104885 0.0167087538071211 0.513211661128791 -0.524910433865085 "APC MUT" "NSC.87877_IC_50" 0.00511814965076586 0.122849424455275 -0.567973534090913 0.00603867445217304 0.256600324448559 -0.572864280311197 0.0216018503739954 0.549211893050681 -0.578005143476377 "SMAD4 MUT" "WZ.1.84_IC_50" 0.000321700753750913 0.0221474759229601 -2.28029400889768 0.00610424958012715 0.258151621529092 -1.49074363504309 0.0484709190854106 0.676839988046433 -1.266023613791 "RUNX1 MUT" "Temsirolimus_IC_50" 0.0831359298593141 0.498552626562699 2.28482310012673 0.00615048361006575 0.258516212987134 2.73984878543793 0.0989771433557145 0.774133667469059 2.04836702160678 "ALK MUT" "Obatoclax.Mesylate_IC_50" 0.0632675322414142 0.450893824743909 -3.02556070956523 0.00617108852080535 0.258516212987134 -3.26532386419591 0.126431532654734 0.817150972850516 -3.36585563498745 "MSH2 MUT" "Sorafenib_IC_50" 0.0157676120001566 0.22780750573449 1.83324227147767 0.00631191627965071 0.263174312110695 1.97738488992799 0.00430340297332366 0.344311007262049 2.27199411877265 "ERBB2 MUT" "DMOG_IC_50" 0.00218409307867877 0.0704826253139796 1.34454748568452 0.00636310536756386 0.263421139925596 1.10829600585305 0.101357508295607 0.774414870229822 0.721283757072332 "MYCN MUT" "Pyrimethamine_IC_50" 0.0120944982097574 0.19730222875419 1.31364770703934 0.00638005763949226 0.263421139925596 1.24183009711556 0.252819900881652 0.875707386589409 0.717420760980935 "VHL MUT" "Epothilone.B_IC_50" 0.0740313200344665 0.47955663984398 -1.48255373989455 0.00641784683734532 0.263421139925596 -1.29540308606426 0.172186562111726 0.842832361237713 -1.19860849864716 "CDKN2a(p14) MUT" "CHIR.99021_IC_50" 2.01139902580555e-06 0.00042251682899365 -0.58345177764665 0.00651411290508341 0.263421139925596 -0.333354391916618 0.0237763027165769 0.568899552891211 -0.301656581736682 "PIK3CA MUT" "CI.1040_IC_50" 0.000499743220103639 0.0301919696444927 0.911928269432408 0.00654065222474567 0.263421139925596 0.642853519037433 0.00220736028644668 0.262338505131915 0.780824836656243 "TP53 MUT" "Epothilone.B_IC_50" 0.0263445957953815 0.300365361459014 -0.4553204335884 0.00658108826848871 0.263421139925596 -0.326382501311745 0.0754416678933582 0.741811190933953 -0.384027454670374 "FBXW7 MUT" "JNK.Inhibitor.VIII_IC_50" 0.0469135175198635 0.384922051833884 0.483158576604557 0.00659091285420686 0.263421139925596 0.631324065685051 0.0413443393216228 0.658180729724545 0.530537616709211 "FGFR2 MUT" "MK.2206_IC_50" 0.0401050040190829 0.36159648801368 -2.59118852164946 0.00659150669888439 0.263421139925596 -2.75480632402324 0.196280530386207 0.851001889249827 -2.24619779545862 "MSH6 MUT" "PAC.1_IC_50" 0.00858222294158379 0.162860516974798 -1.61035777416521 0.00661736217141578 0.263421139925596 -1.39014522757021 0.0125877504843776 0.475709838518119 -1.46493714805692 "NRAS MUT" "Gefitinib_IC_50" 0.090176847339545 0.514691890245822 0.462638166470148 0.00663991780958193 0.263421139925596 0.689830755591016 0.135638182921029 0.828937189282754 0.417519436782362 "EGFR MUT" "Gefitinib_IC_50" 0.0181984460466289 0.247069557579196 -0.815347843873515 0.00664410937319372 0.263421139925596 -0.840176022018357 0.0117774334993444 0.459749370120074 -0.820338670243828 "SMO MUT" "BIBW2992_IC_50" 0.0278594919984387 0.309275185547668 -2.94823693548386 0.00675965650161162 0.266241915891135 -3.45970129843245 0.0768519558701603 0.741811190933953 -2.18310282174878 "TP53 MUT" "PF.4708671_IC_50" 0.139794574913294 0.609482385765814 0.173766345312115 0.00677521371370302 0.266241915891135 0.334212079855118 0.0287958018349203 0.597512888074595 0.280626491437157 "BRAF MUT" "X681640_IC_50" 0.146321240113487 0.619919550890177 0.344024865363271 0.00686416045510241 0.266826428617175 0.602903028781233 0.244086357309234 0.875707386589409 0.313638364242557 "CDKN2a(p14) MUT" "Salubrinal_IC_50" 0.0006139873986682 0.0334674144960997 -0.726829526315791 0.00687338953602448 0.266826428617175 -0.509128153084301 0.0322327423531835 0.618827479917328 -0.516935703020653 "BRAF MUT" "GSK.650394_IC_50" 0.802743029302473 0.951554805207856 0.0736979905956104 0.00688022206433206 0.266826428617175 0.553137367358789 0.908530666946898 0.989534075687441 -0.040380167420035 "MS-HL MUT" "JNK.9L_IC_50" 0.000680490116847366 0.0351701883538398 -0.591680155747772 0.00714697795016087 0.275966570327734 -0.368706097112742 0.00329682851169705 0.304990979295641 -0.565141022942075 "KRAS MUT" "JNJ.26854165_IC_50" 6.43563118468928e-05 0.0069081077612257 0.562159672903677 0.00724557601945715 0.276655409845321 0.375658073568607 0.0034025598830047 0.307545333416453 0.454487300408986 "NF1 MUT" "Methotrexate_IC_50" 0.00878912412691226 0.164675551415839 1.28971182886903 0.00725827958085493 0.276655409845321 1.01227242658056 0.0340088029727711 0.618827479917328 0.88033946067352 "SETD2 MUT" "DMOG_IC_50" 0.052237941587396 0.407309182824991 -2.45710224137936 0.00728315340559892 0.276655409845321 -3.07171913983522 0.0378966480150036 0.645472009508728 -2.47988687865476 "TP53 MUT" "GNF.2_IC_50" 0.116125496978252 0.570433713690719 -0.238322505561073 0.00728942302711464 0.276655409845321 -0.416180217258093 0.0400266573568921 0.650999329179205 -0.347972304370795 "CDKN2C MUT" "PF.02341066_IC_50" 0.015681289926174 0.227586688087166 -1.61281958843537 0.00739055091622574 0.278555369968349 -1.65042531982841 0.0639571639455499 0.70585538398383 -1.4757003249396 "BRAF MUT" "PD.173074_IC_50" 0.00484808710774624 0.118938844209653 0.581490064412242 0.00740221453806219 0.278555369968349 0.515431185169571 0.014680684425981 0.490024700267999 0.557914053619663 "TP53 MUT" "S.Trityl.L.cysteine_IC_50" 0.71705207493393 0.921306561002511 -0.0916721709036743 0.00756896233815346 0.283317316769696 0.388637791447252 0.678243217445569 0.961100601384891 -0.117619401166471 "SMAD4 MUT" "S.Trityl.L.cysteine_IC_50" 0.416012416836985 0.814099702076568 -0.648881493326742 0.007592559553112 0.283317316769696 1.1995544496404 0.632710942379812 0.952523560833852 -0.410559415644212 "EWS_FLI1 MUT" "Bortezomib_IC_50" 0.510466845823979 0.849393770898084 -0.455167542264745 0.00762663091998303 0.28339794644506 -1.622946971007 0.119633740404675 0.807345933536413 -1.17405114666107 "MDM2 MUT" "X681640_IC_50" 0.000550745590965044 0.0319684417866703 1.78923047835053 0.00773332247338196 0.286089929533362 1.18150659181843 0.000533828916242129 0.124761436977535 1.67235757111965 "EGFR MUT" "BIBW2992_IC_50" 0.00445682840094037 0.112086532892633 -1.14553595849802 0.00776350332367304 0.286089929533362 -1.02556771797167 0.0139109499661147 0.482141194305023 -0.959404371175541 "CCND1 MUT" "AZD.2281_IC_50" 0.00134786599749558 0.0536789144563151 0.979494773195873 0.00787492562281768 0.288996753951421 0.61800490295009 0.0293575033211768 0.59799127175549 0.633801475817103 "MLH1 MUT" "Docetaxel_IC_50" 0.00113596249186438 0.0487366323200363 1.78353036756561 0.00792738384202064 0.289326955944587 1.10309162707954 0.000994946693964645 0.160771667262499 1.75246314140114 "MLL_AFF1 MUT" "RO.3306_IC_50" 0.00520017174144493 0.123814276771508 -2.89886474609371 0.00794907974895612 0.289326955944587 -2.66860239988815 0.00818526963044758 0.397959104863583 -2.77506645128867 "SETD2 MUT" "WO2009093972_IC_50" 0.000616358326984145 0.0334674144960997 -3.71609037788021 0.0080557355973316 0.290053320210952 -2.6130776447321 0.00368884268783663 0.31500588375651 -3.11529326279428 "CDK6 MUT" "Mitomycin.C_IC_50" 0.20347891786984 0.675665259036525 -1.00261806502636 0.00805781774718771 0.290053320210952 -1.63049192728437 0.36902839873886 0.913948248824328 -0.736542710918789 "CDKN2a(p14) MUT" "Vorinostat_IC_50" 0.579116677960364 0.874194311383525 0.0639052445729881 0.00806701611216136 0.290053320210952 0.241128463216976 0.783995368517901 0.974078058737889 0.0320630170060893 "CDKN2A MUT" "GDC.0449_IC_50" 0.273380633882537 0.734000646544246 0.117741329340247 0.00833752930809034 0.29857095881109 0.26282557284477 0.19888971451193 0.851001889249827 0.155309726490387 "CDK6 MUT" "AZD6482_IC_50" 0.0785662166470908 0.486980385654137 -1.16045240314136 0.00850063164101099 0.303175604339425 -1.46156469256485 0.227112758490337 0.867648638924452 -0.824069615260805 "MSH6 MUT" "A.770041_IC_50" 0.036513470730622 0.349245910703174 -2.68202918771329 0.00856627255198138 0.303175604339425 -2.73445018628253 0.00704745633018662 0.381508554648877 -3.25060939217584 "ERBB2 MUT" "PAC.1_IC_50" 0.147066265697969 0.619919550890177 -0.615606285924368 0.00856852569408801 0.303175604339425 -0.957685609681599 0.00635063780166337 0.370691368090687 -1.18150518807743 "CCND1 MUT" "VX.702_IC_50" 0.00760777469535435 0.153207816483996 0.816868259481042 0.00862594491641494 0.303996098423338 0.663050256031839 0.110978405653115 0.797376436030023 0.490236467350678 "MYCN MUT" "X17.AAG_IC_50" 0.00211955608322443 0.0691892172474566 1.49533751599851 0.00866855112405983 0.304290128588045 1.15578841912051 0.0483884024171054 0.676839988046433 -1.02641357766865 "RB1 MUT" "Z.LLNle.CHO_IC_50" 0.00188887770604245 0.0655278238568866 0.922906110763854 0.00872463881746653 0.304591221190217 0.745656558462634 0.323725777969811 0.900918773778407 0.337001252005104 "MYCN MUT" "Temsirolimus_IC_50" 0.178029847067586 0.656868746076954 0.717076121568624 0.00874572248660121 0.304591221190217 1.09609532068132 0.0598275134524065 0.70215997387469 1.1144067806979 "MYCN MUT" "ZM.447439_IC_50" 0.00982164894195712 0.175505159463825 -0.916519921858386 0.00889271139564383 0.308500663690285 -0.762914472365528 0.0975570716286929 0.772625185318248 -0.676269615611966 "CDKN2a(p14) MUT" "BIBW2992_IC_50" 0.05415050082326 0.416012627864509 0.326258756880735 0.00906234727927307 0.313162280884141 0.438991968472641 0.156751565255901 0.837288218996252 0.247547603161795 "MSH6 MUT" "GDC.0449_IC_50" 0.000584673891685781 0.0332380402971253 -1.58985405458088 0.00913338601449214 0.314393803080251 -1.07633313251147 0.00142146079263685 0.205968687037918 -1.45475773600147 "MSH2 MUT" "Bortezomib_IC_50" 0.0151364427065417 0.22367179313943 2.45462416838489 0.00919839761312725 0.315409147498776 2.14567977844412 0.0912303340562185 0.764454987127048 1.64847629261471 "ALK MUT" "ABT.263_IC_50" 0.00664902102735048 0.14099460473473 -3.40662675603395 0.00936734023996756 0.319966725658277 -2.93776001822485 0.610995142608961 0.949930222127033 -0.684156386164062 "NRAS MUT" "BIBW2992_IC_50" 0.0313565115259127 0.328006099954806 0.68590278593633 0.00943287993843167 0.320730738304343 0.821173714109275 0.435361833831132 0.922569292988365 0.26157911803593 "NRAS MUT" "Pyrimethamine_IC_50" 0.230261204783962 0.703215185586782 0.604774520787054 0.00946193597970249 0.320730738304343 1.14441587465897 0.0385612240979311 0.646945958867072 1.16875467863453 "FBXW7 MUT" "Vinblastine_IC_50" 0.177349388350222 0.656513564381252 -0.513357039525688 0.00963581918018677 0.325376937667219 -0.718572169641254 0.0743417962285847 0.741811190933953 -0.674619109164952 "MYC MUT" "Z.LLNle.CHO_IC_50" 0.00128651372513306 0.0519342199677576 1.23354161642156 0.0096722791965033 0.325376937667219 0.935393973794464 0.0168050695988831 0.513211661128791 0.949617132858694 "BRAF MUT" "WO2009093972_IC_50" 0.476916174533783 0.835993679974334 -0.166210555080949 0.009749997516368 0.326434822784242 -0.59754449879727 0.324433100297306 0.900918773778407 -0.26544830451731 "HRAS MUT" "Tipifarnib_IC_50" 0.316653010995564 0.761258739353268 -1.0064762132867 0.00977723937176087 0.326434822784242 -1.73074618503199 0.518717190496544 0.939635632721979 -0.638952030138095 "CDKN2C MUT" "DMOG_IC_50" 0.0781007741828879 0.486980385654137 -1.00455905594406 0.00986555192906005 0.328149687947499 -1.32646321382746 0.204014288020845 0.853438950500765 -0.815734593894536 "ERBB2 MUT" "Midostaurin_IC_50" 0.0123764086879351 0.200541834057986 1.14734416730868 0.0100573838284604 0.330714528810643 0.936606520819285 0.126740481565268 0.817150972850516 0.676466036755321 "PIK3CA MUT" "ABT.888_IC_50" 0.563655168996099 0.871754997395969 -0.08993355882353 0.010094419340281 0.330714528810643 -0.34136180632126 0.156754314934801 0.837288218996252 -0.226945615820043 "NOTCH1 MUT" "Gemcitabine_IC_50" 0.285120544910508 0.740302864659114 -1.09778962477719 0.0101669825335365 0.330714528810643 1.83581675810586 0.663795545689975 0.959206771190239 0.461165005778987 "CCND1 MUT" "ABT.888_IC_50" 0.00255545666257416 0.0777226391106888 0.650751549800793 0.0102339311462635 0.330714528810643 0.470921350051727 0.0177899270882787 0.513211661128791 0.516670390096336 "NF1 MUT" "Camptothecin_IC_50" 0.358385122599921 0.786601117838604 -0.449280268423882 0.0102895958640918 0.330714528810643 -0.794559598705945 0.105926169383245 0.788168661441703 -0.740640397057372 "CTNNB1 MUT" "PF.4708671_IC_50" 0.0399575905702977 0.361141839503332 -0.704618310397565 0.0102991623046452 0.330714528810643 -0.872782646245321 0.0427980126592733 0.658180729724545 -0.781114463333642 "TET2 MUT" "Obatoclax.Mesylate_IC_50" 0.0533798867733476 0.413242516911974 -2.5714097119628 0.010305166754114 0.330714528810643 -2.53842925052795 0.0838135816468 0.747337769683966 -2.70586909196026 "MET MUT" "SB.216763_IC_50" 0.0646750938205021 0.456581485071446 -0.784042210072899 0.0103286673055374 0.330714528810643 -1.0529707774213 0.0239680561037056 0.569786836641336 -0.922852441550683 "BRCA1 MUT" "Erlotinib_IC_50" 0.0171227014736733 0.240174702440681 -2.89448840000001 0.0103392566463348 0.330714528810643 -2.79439077181111 0.021650187336333 0.549211893050681 -2.75819265919881 "SMO MUT" "Mitomycin.C_IC_50" 0.0131186926780248 0.207480784061478 -3.88320693739132 0.0103657737162504 0.330714528810643 -3.12298631299716 0.00350484821910917 0.307545333416453 -4.41769277185181 "NRAS MUT" "Epothilone.B_IC_50" 0.825755739133645 0.957177484110155 0.0823446563862925 0.0103808553002656 0.330714528810643 0.564335303147786 0.678839600404934 0.961100601384891 0.172702541550212 "KRAS MUT" "BMS.754807_IC_50" 0.000523145275626726 0.030973687952273 -0.947107517147072 0.0103895229746841 0.330714528810643 -0.617024444287925 0.0594897631497227 0.70215997387469 -0.579343617621652 "NRAS MUT" "AP.24534_IC_50" 0.175730717495453 0.654035305374445 0.59989443783069 0.0104803400758125 0.331915773533808 1.04873819869101 0.022044404346707 0.552040423342173 1.08871348668246 "CDKN2C MUT" "PD.0332991_IC_50" 0.124502246140417 0.585102471530182 -1.07807355375783 0.010502007922869 0.331915773533808 -1.43517094458337 0.345785204196719 0.908824622216945 -0.664390868130775 "MLH1 MUT" "GW843682X_IC_50" 0.00676833259184697 0.142704889977861 2.35236626297579 0.0105931954452027 0.33209527714368 1.15557522118307 0.00752208644751965 0.387627335508924 2.43941531917129 "MS-HL MUT" "DMOG_IC_50" 0.286101791247265 0.741088279034661 0.243189587053573 0.0105979245084908 0.33209527714368 0.526515361699493 0.300673563665646 0.894167310052 0.247622614646337 "CDKN2a(p14) MUT" "MG.132_IC_50" 0.000201873141551011 0.0157266260536362 -1.08280016958699 0.0106198692386899 0.33209527714368 -0.71389387207476 0.15845618569677 0.83854630828105 -0.43901617656307 "STK11 MUT" "BIRB.0796_IC_50" 0.0836060690233016 0.500295367140933 -0.447933695652175 0.0108108201255954 0.336880328194431 -0.631302631724585 0.131959094129276 0.824721122422311 -0.412038701322151 "TSC1 MUT" "AP.24534_IC_50" 0.0442012100676794 0.376006653842012 -3.93817074137937 0.0110779204921593 0.342850506184841 -4.47805225954903 0.101114182441629 0.774133667469059 -3.01044081315694 "MLL_AFF1 MUT" "Rapamycin_IC_50" 0.270635090660851 0.733000988154624 2.35540402348991 0.0110796188801992 0.342850506184841 4.7169350081305 0.249980234496524 0.875707386589409 2.50251146252286 "PTEN MUT" "Erlotinib_IC_50" 0.0532076870525355 0.412696479225824 0.539680890804597 0.0112757998595371 0.345753146192306 0.649119935523501 0.0115895448634832 0.45915934099059 0.762729089869684 "MLH1 MUT" "Salubrinal_IC_50" 0.00352261684181023 0.0963814374491735 1.78605000000001 0.0113206787572234 0.345753146192306 1.29309112445402 0.000653607688196876 0.136359401988489 2.09295144327057 "NOTCH1 MUT" "Vinblastine_IC_50" 0.000354423805374806 0.0242125985810281 -1.71805830069351 0.0113247743305117 0.345753146192306 -0.933544676191189 0.0513761247024246 0.689395114310948 -0.959479872020203 "MSH2 MUT" "PHA.665752_IC_50" 0.00654610375035861 0.140500515172104 -1.52716554421768 0.0113598490970657 0.345753146192306 -1.42315743668922 0.00400517949361515 0.332429897970058 -1.68539736634156 "EGFR MUT" "NU.7441_IC_50" 0.20096446952976 0.674012093366938 0.407430716627632 0.0114907604243924 0.345753146192306 0.709401486686527 0.180817020411052 0.848722027112292 0.431941384812525 "CDK6 MUT" "MG.132_IC_50" 0.0891471028579774 0.514272513671442 -2.32662065536723 0.0114922814922121 0.345753146192306 -3.03257597282335 0.372027938985865 0.913948248824328 -1.39263025053835 "KIT MUT" "Thapsigargin_IC_50" 0.0103718367328318 0.181016440658339 -3.30353705244758 0.0115240272415694 0.345753146192306 -2.48886241298601 0.0218404083588575 0.549474976303153 -2.87858111170731 "PTEN MUT" "PLX4720_IC_50" 0.0280369463334622 0.309508303338214 -0.519634199916105 0.0115291267194905 0.345753146192306 -0.54226528224572 0.048146742619427 0.676839988046433 -0.462092320056494 "FBXW7 MUT" "AZD7762_IC_50" 0.0622227560011211 0.448539201336004 -0.709468305814357 0.0115953357117008 0.345753146192306 -0.75209328599819 0.368992960545251 0.913948248824328 -0.330009690995662 "FLT3 MUT" "A.770041_IC_50" 0.00821611001822284 0.159584363220549 -3.89898291496603 0.011645181432496 0.345753146192306 -3.04901905792228 0.00528583195765245 0.358956332448686 -3.92543528534382 "CDKN2A MUT" "PHA.665752_IC_50" 0.00194313051081512 0.0658661910936987 -0.506685202546297 0.0116848128623458 0.345753146192306 -0.42919578517918 0.128424485688826 0.820169751013594 -0.295611973560099 "MYC MUT" "PF.562271_IC_50" 0.0367349203105018 0.350045952014557 0.501705855694495 0.011719259196665 0.345753146192306 0.498313886561609 0.131598243797207 0.824721122422311 0.376069546310639 "NOTCH1 MUT" "Cisplatin_IC_50" 0.205755238925712 0.678793564970003 0.567898835228858 0.0117375013554354 0.345753146192306 1.03237190539329 0.013156487504366 0.482141194305023 1.15536499504692 "NRAS MUT" "AZD.0530_IC_50" 0.0185556468768257 0.248885968328711 1.02834659782608 0.0117411589598485 0.345753146192306 0.982150395612152 0.0995370981763696 0.774133667469059 0.757175729210066 "MSH2 MUT" "Tipifarnib_IC_50" 0.00477365640318208 0.118778793432633 -2.39409477393486 0.0117573978324599 0.345753146192306 -1.43246896108433 0.00915024538158969 0.425462456721979 -2.19730904437631 "CDKN2A MUT" "ABT.263_IC_50" 0.0291875358349227 0.316210068663154 0.419283131715505 0.011909769073961 0.348298888332223 0.453640586395805 0.830615189838521 0.981482581683432 0.0406430603576848 "FLCN MUT" "AICAR_IC_50" 0.0202516448958619 0.258412152758836 2.29949922480621 0.0119224031137255 0.348298888332223 2.22483531955316 0.138176198179061 0.831473272394224 2.43153892878103 "FGFR3 MUT" "CGP.082996_IC_50" 0.00237757980012209 0.0742339630995983 -3.49885921768708 0.0119856774334242 0.348758938305477 -2.43282070825214 0.0072712148033596 0.383871009534609 -3.06382486886714 "ALK MUT" "X681640_IC_50" 0.190149628805233 0.664991779417723 1.51266619066936 0.0120174567230939 0.348758938305477 2.47823426504775 0.0842846790499981 0.747749574262573 1.88029901016951 "EWS_FLI1 MUT" "Cytarabine_IC_50" 0.000101100366501978 0.00975948211852247 -2.07450627683777 0.0120932543130069 0.348758938305477 -1.08146586132918 0.0766694511594994 0.741811190933953 -1.01511528056798 "HRAS MUT" "KU.55933_IC_50" 0.0524470619208975 0.408581014841659 -0.997865175613001 0.012107533879104 0.348758938305477 -1.15128811282899 0.0591694913565531 0.70215997387469 -0.956435792257766 "BRCA1 MUT" "GW843682X_IC_50" 0.151551467537809 0.625830613280407 2.47702818644067 0.0121345019633366 0.348758938305477 2.22129499720717 0.263542163034146 0.877052916121269 2.02978401241131 "PTEN MUT" "BIBW2992_IC_50" 0.149907135369462 0.62474203154209 0.340045625374446 0.012227297425087 0.350292349781281 0.578398545754129 0.180911624163661 0.848722027112292 -0.317149254166236 "KIT MUT" "Imatinib_IC_50" 0.00115869938760638 0.0492364079489582 -3.17766597643093 0.0122717861508189 0.350405756651538 -2.52339686172995 0.0106678661190046 0.450367315182713 -2.66758344266134 "FBXW7 MUT" "Embelin_IC_50" 0.0145451269601549 0.219273935922674 -0.758498879606871 0.0123101673319761 0.350405756651538 -0.619321305895938 0.0135390336981313 0.482141194305023 -0.788432719944938 "FBXW7 MUT" "Temsirolimus_IC_50" 0.0673201189910752 0.460513103960953 0.888165343873512 0.0123655421254918 0.350857442864195 0.929939533680587 0.0622232315802956 0.702860976445846 0.909957064872115 "NOTCH1 MUT" "Mitomycin.C_IC_50" 6.46961850133091e-06 0.00117258534510857 -2.51188305080215 0.012442708909263 0.351211114629107 -1.14102061381397 0.00562881307255415 0.358956332448686 -1.66111681263307 "BCR_ABL MUT" "BIRB.0796_IC_50" 0.41303799219872 0.812625256694026 -0.499416347992356 0.0124570995505201 0.351211114629107 1.76944611802735 0.545663000421257 0.946853280734584 -0.376402695568073 "APC MUT" "Pazopanib_IC_50" 0.0006025587757952 0.0332380402971253 1.1873526187522 0.0124987402790378 0.351269976006756 0.767816694708383 0.0270038821381612 0.588860092297546 0.853413656446673 "EWS_FLI1 MUT" "Docetaxel_IC_50" 0.00434758753222926 0.110002634967886 -1.39105162732921 0.0125659093472505 0.352043662185904 -0.971143443325662 0.146606053552361 0.831473272394224 -0.790822114371566 "KDM5C MUT" "BIRB.0796_IC_50" 0.00617022361991665 0.136590680167686 -1.92124592875323 0.0127192941930473 0.353673947624865 -1.67279973642578 0.00356684712778907 0.307545333416453 -2.00716657375034 "NOTCH1 MUT" "BI.D1870_IC_50" 0.000168468068173985 0.0139828496584408 -1.6290598098023 0.012728365128014 0.353673947624865 -0.971830120140106 0.0284579663252468 0.595164254286719 -0.984560161499328 "TSC1 MUT" "Mitomycin.C_IC_50" 0.0633307425922584 0.450893824743909 -2.91028960695655 0.0127435720346759 0.353673947624865 -3.05181846225978 0.217151174152069 0.860928912580141 -1.87669669310458 "SOCS1 MUT" "BI.D1870_IC_50" 0.00425564594242534 0.107983976041941 -3.24647796380959 0.0128148577900551 0.354544398858191 -2.44402865210597 0.0109305053665034 0.450437967177441 -2.73891966607984 "ERBB2 MUT" "Vorinostat_IC_50" 0.741900009061832 0.929570057037101 0.105889232287449 0.0129946567310506 0.358402318100807 -0.628969346741343 0.115990029116084 0.802355750183445 -0.491999191465119 "CDKN2C MUT" "AZD8055_IC_50" 0.103012697775721 0.543909494022696 0.823760492234464 0.0130687496616813 0.359175049550997 0.977283099827031 0.0386383650941124 0.646945958867072 1.08246265384882 "CCND1 MUT" "Lenalidomide_IC_50" 0.00150813502638674 0.0569603689624804 0.686897869047624 0.0131035599656033 0.359175049550997 0.475469072137728 0.00471866658453012 0.349220649476767 0.632861087905205 "MSH2 MUT" "Cisplatin_IC_50" 0.0367124463694921 0.350045952014557 1.31525783004926 0.0132501408814244 0.361555082579032 1.35223053625117 0.0427765505766403 0.658180729724545 1.23028020151997 "CDKN2A MUT" "AZD6244_IC_50" 7.08780861369306e-05 0.00725859663615262 -0.804310400207867 0.0133084184373372 0.361555082579032 -0.475862207791354 0.0431778009277578 0.658180729724545 -0.41989200381851 "MYCN MUT" "JNK.Inhibitor.VIII_IC_50" 0.00268419175078635 0.079461023129112 -0.76050035196688 0.013312522464063 0.361555082579032 -0.622193597612379 0.029725981576506 0.59799127175549 -0.674758957120935 "CDKN2a(p14) MUT" "Imatinib_IC_50" 0.000512622926510825 0.0305543906734405 -0.592481906814448 0.0136623596111996 0.368740908313843 -0.437701774630104 0.0131961481361148 0.482141194305023 -0.508496090346304 "NOTCH1 MUT" "RO.3306_IC_50" 0.0825334061982942 0.498292292071189 0.690485451428569 0.0137416029491678 0.368740908313843 0.967773166781466 0.0511874626181002 0.689395114310948 0.843574669012075 "NRAS MUT" "Imatinib_IC_50" 0.0424114597943428 0.370724581135392 0.610493152173909 0.0137697454226423 0.368740908313843 0.754304943498648 0.0184000732662138 0.513871228544795 0.834197846383108 "PTEN MUT" "Vorinostat_IC_50" 0.588160625704314 0.876506729771444 0.086654792514342 0.0137729056471499 0.368740908313843 0.307059243930092 0.922368255850757 0.993931766508607 -0.0154235477169168 "FBXW7 MUT" "PAC.1_IC_50" 0.00546233719643322 0.126330772503967 -1.03906382325961 0.0138170145392047 0.368740908313843 -0.769948510702747 0.107676169354282 0.792785095696032 -0.604723960961226 "CDKN2A MUT" "CCT018159_IC_50" 0.239139056617315 0.711012374227778 0.158746516054288 0.0138810505878211 0.368740908313843 0.319475768472454 0.0697832178147869 0.724728470922855 0.279633395288148 "MSH2 MUT" "A.770041_IC_50" 0.0978396361208193 0.534387336032593 -1.7419110378007 0.0139054879009316 0.368740908313843 -2.11217964533434 0.0369051288941376 0.6397150794459 -2.12503331992497 "KRAS MUT" "SB590885_IC_50" 0.411131279212856 0.812480994891775 0.184445083732056 0.0139314247541462 0.368740908313843 0.494029332770421 0.0216261395582897 0.549211893050681 0.530013981443724 "MSH2 MUT" "X17.AAG_IC_50" 0.089410308819388 0.514272513671442 1.41658667719779 0.0139855237093886 0.368740908313843 1.80226533359096 0.56610629701601 0.949294892873838 0.423762991300574 "CDKN2A MUT" "PLX4720_IC_50" 6.38217435019953e-05 0.0069081077612257 -0.657118941228073 0.0141108315137643 0.368740908313843 -0.37487721634129 0.0251820954264457 0.576397395572846 -0.382247721694155 "IDH1 MUT" "BMS.708163_IC_50" 0.0155207268110518 0.227586688087166 -2.074886890625 0.0141381852962928 0.368740908313843 -2.10623526546253 0.00534756525049309 0.358956332448686 -2.42823851054896 "PIK3CA MUT" "Midostaurin_IC_50" 0.551379478426586 0.865580796066258 0.159002431818183 0.0141426221475008 0.368740908313843 0.51181990290453 0.526340084752776 0.941286003360735 0.168756325024296 "KIT MUT" "Axitinib_IC_50" 0.0112702372283557 0.188850899669862 -2.25508490571431 0.0141741799885128 0.368740908313843 -1.84510824345911 0.0120618852874651 0.459749370120074 -1.97701966468519 "APC MUT" "JNK.Inhibitor.VIII_IC_50" 0.000904480133595498 0.0425009950606435 0.698290806451618 0.0141885850848371 0.368740908313843 0.512421498598349 0.0854966166635584 0.749680540483183 0.449476331978169 "PTEN MUT" "Rapamycin_IC_50" 0.0124195483314821 0.200541834057986 -1.18153735515872 0.0142261360170451 0.368740908313843 -1.00228691411057 0.0440114896143743 0.659657620288543 -1.04275821594391 "SMAD4 MUT" "Temsirolimus_IC_50" 0.00333477698788221 0.0937220076879173 1.31702163258079 0.0142414290678582 0.368740908313843 0.856011977866051 0.144478623899712 0.831473272394224 0.662061269483069 "MYCN MUT" "Rapamycin_IC_50" 0.00378051572420749 0.101434320684854 1.96303112800818 0.014369665438886 0.370979647566124 1.4557182358393 0.197215006587559 0.851001889249827 1.06872522558545 "MDM2 MUT" "Bexarotene_IC_50" 0.0457805967037408 0.382012167839182 -1.02167857319224 0.0144516115994407 0.372013804680096 -1.11202824333081 0.106777338898656 0.792410790279379 -0.785835235688518 "MS-HL MUT" "CEP.701_IC_50" 0.0630670872099997 0.450893824743909 -0.459969420771166 0.0144965754862927 0.372092736687183 -0.444839608794192 0.0119042375999974 0.459749370120074 -0.616021872276559 "FLCN MUT" "Paclitaxel_IC_50" 0.102809052649384 0.543688489044222 2.46005494557824 0.0146078265209913 0.37263143726533 1.58907091271934 0.456313179095034 0.925809648901546 1.98370912893024 "CDKN2a(p14) MUT" "GDC.0449_IC_50" 0.0994921140026267 0.5374999166548 0.181553614718615 0.0146254432456005 0.37263143726533 0.248971051340596 0.0441666660268454 0.659657620288543 0.24473225056852 "BCR_ABL MUT" "FTI.277_IC_50" 0.0753515822494246 0.480779116570693 0.981832051903104 0.0146434378567279 0.37263143726533 1.47014041749672 0.103257430803485 0.780450419545322 0.870333605788905 "PIK3CA MUT" "PF.02341066_IC_50" 0.0373412695237568 0.351300651102208 0.956778352452429 0.0146869485947031 0.372670829913022 1.03652739306463 0.0680804004475103 0.719539038493615 0.900841765832386 "MYCN MUT" "IPA.3_IC_50" 0.0262829746731296 0.300365361459014 -1.04163095870735 0.0147765654438536 0.373876574663429 -0.980374421670308 0.0551027636758049 0.697305726351784 -0.969819036604361 "TP53 MUT" "WO2009093972_IC_50" 0.113032697310564 0.563938179281427 0.247541846197449 0.0149223842343143 0.375795575831836 0.363919369814526 0.0373213453057896 0.643593917787801 0.346950251082569 "RB1 MUT" "AZD6244_IC_50" 0.00832757985233516 0.160289453825376 0.871680742669553 0.0149370384268256 0.375795575831836 0.741651194412838 0.315818407146277 0.900294798053993 0.331204742293135 "VHL MUT" "AZD6482_IC_50" 0.00107825087315314 0.0477221605268402 -2.27810348344944 0.0150187349480841 0.376783573655184 -1.43796985792287 0.00647201876824274 0.370691368090687 -2.01031721537612 "FBXW7 MUT" "Elesclomol_IC_50" 0.00845287754936225 0.161440872077175 1.2189388715415 0.0151966210809093 0.377300823838217 0.931794241217409 0.147471162549548 0.831473272394224 0.672453519691081 "KDM5C MUT" "GDC0941_IC_50" 0.069681965124779 0.467745102207087 1.90480931893001 0.0152381806524969 0.377300823838217 2.04605013563373 0.0617518183508729 0.702860976445846 1.93449915710372 "MS-HL MUT" "MG.132_IC_50" 0.00812744573969549 0.158981783709833 1.09282420648235 0.0152493810956912 0.377300823838217 0.901166467567027 0.267666036101783 0.877052916121269 0.476919437443175 "TP53 MUT" "CGP.60474_IC_50" 0.313219765716095 0.759215564942334 0.22721239285005 0.0152631312298368 0.377300823838217 0.429916325455318 0.324067198430018 0.900918773778407 0.238264208442196 "TP53 MUT" "Salubrinal_IC_50" 0.353557859364521 0.785062892590933 0.194314267015707 0.0152645034600012 0.377300823838217 0.436714595803508 0.237326243030488 0.873248794735437 0.26779799016969 "FGFR3 MUT" "JW.7.52.1_IC_50" 0.0102554286595347 0.179996960326734 -4.8724578983051 0.0153576596113172 0.377300823838217 -2.77365214666334 0.0162971441816065 0.511430874476493 -4.63703476397486 "BRCA2 MUT" "Cytarabine_IC_50" 0.861881862617877 0.966461214887546 0.155100713740461 0.0153730143310896 0.377300823838217 -1.63595765025576 0.336839224900949 0.905430766021494 -0.799889049585572 "PIK3CA MUT" "A.443654_IC_50" 0.121215826686323 0.580333022534361 -0.889648947540092 0.015482005314751 0.377300823838217 -0.899688964004502 0.188227481540241 0.851001889249827 -0.84606238377976 "BRAF MUT" "AZD7762_IC_50" 0.308681990989712 0.75674113273833 0.259118739522339 0.0155132310738361 0.377300823838217 0.529214945662136 0.593568518769402 0.949294892873838 0.147577794334118 "CCND1 MUT" "Camptothecin_IC_50" 0.018790207253158 0.24981411768757 1.07903640515874 0.0155169203547448 0.377300823838217 0.708834140992517 0.329511949149675 0.902810042912437 0.427152987784034 "TP53 MUT" "PD.0332991_IC_50" 0.726350584313814 0.92547791524492 0.0665493807912857 0.0156208836942857 0.377300823838217 -0.387517040559045 0.444887487227124 0.925809648901546 -0.146622335186975 "NF1 MUT" "Pyrimethamine_IC_50" 0.0035379291305518 0.0963814374491735 1.84329824331145 0.0157065607468119 0.377300823838217 1.30078172599205 0.0697149058490989 0.724728470922855 1.30790490083492 "NF2 MUT" "AZD6482_IC_50" 0.317806482837325 0.761258739353268 0.436415398777692 0.0157181923210571 0.377300823838217 0.896588545856036 0.017253109887997 0.513211661128791 1.09223467165527 "PIK3CA MUT" "Nilotinib_IC_50" 0.889610129794922 0.975627014412041 0.0332107303660704 0.0157619401895628 0.377300823838217 -0.476480127362292 0.808790286882479 0.977383317127464 -0.0572885386489085 "APC MUT" "AZD.2281_IC_50" 0.163146862643691 0.638639513991862 0.392619593750002 0.0157665214272815 0.377300823838217 -0.539038399930437 0.23453332980925 0.869962136993019 -0.360407426073277 "SMO MUT" "Metformin_IC_50" 0.0271030494964526 0.305459622560908 2.24957585551327 0.0157939801366126 0.377300823838217 2.27950537857243 0.0274149687560901 0.588860092297546 2.1915548053149 "KRAS MUT" "AZD6482_IC_50" 0.00140218564246137 0.0548424861786086 0.745048309414629 0.0158473589794103 0.377300823838217 0.502842663325291 0.0541518685287451 0.697305726351784 0.503749074760551 "ALK MUT" "AS601245_IC_50" 0.0466029547522781 0.384195372885338 2.53467469217392 0.015854274077265 0.377300823838217 2.4553837657249 0.27545639857457 0.883780956691668 1.93684459428446 "SMAD4 MUT" "X17.AAG_IC_50" 0.00407208871768784 0.104965206135984 -1.26320228849993 0.0158830616731267 0.377300823838217 -0.952342398597233 0.0230280978785984 0.562231369976192 -0.935509281905783 "FGFR2 MUT" "Cisplatin_IC_50" 0.0120610678649079 0.197279135305959 2.9402413149905 0.0159241853095728 0.377300823838217 2.46061602763742 0.040935276086366 0.656220554012665 3.23825087799036 "MYCN MUT" "Bexarotene_IC_50" 0.00265147868623866 0.079403115828963 1.09436094973069 0.0160220929145704 0.377300823838217 0.800026722212647 0.505553206734118 0.93586286551405 0.269660634804517 "MSH2 MUT" "WO2009093972_IC_50" 0.00537263292922673 0.125234522426411 -2.14600723148149 0.0160243668397346 0.377300823838217 -1.67189235435117 0.000178496021101514 0.0511362310775015 -2.84052206447958 "NOTCH1 MUT" "Nilotinib_IC_50" 0.335778208055212 0.773352247338781 -0.426993973370325 0.0160373123209623 0.377300823838217 0.896756761497762 0.314043686567214 0.900294798053993 0.436414344762739 "KDM6A MUT" "JNK.Inhibitor.VIII_IC_50" 0.00111330994932447 0.0482307593168321 -0.888840043658587 0.0160589698694793 0.377300823838217 -0.635117469476887 0.00163471778332821 0.219968615662695 -0.891733183306292 "CDK4 MUT" "CCT018159_IC_50" 0.141968677702475 0.614480736917568 -0.663680697674422 0.0161987271051478 0.379580198999519 -1.01148122449605 0.141949968806386 0.831473272394224 -0.701184641182057 "KIT MUT" "FTI.277_IC_50" 0.00320752043137503 0.0910095493643503 -1.45315811091853 0.0162725360422434 0.380306296292536 -1.08285283315881 0.0116327949243196 0.45915934099059 -1.18369581969464 "TET2 MUT" "X681640_IC_50" 0.000191748236254013 0.015204607912249 -3.49790501626026 0.0163264963208484 0.380565915552375 -1.95878978045623 0.0673204419681691 0.71773450794635 -1.9911528765585 "KDM5C MUT" "Bortezomib_IC_50" 0.168327483363866 0.647446641789 -1.7971211433447 0.0164711279425158 0.382932165595505 -2.54394629030969 0.128188781434038 0.820169751013594 -1.87377212004642 "KDM6A MUT" "Nilotinib_IC_50" 0.00124382579056145 0.0513786830045408 -1.3363348780458 0.0165398232323976 0.383525248373168 -0.809645471006989 0.0107347853973883 0.450367315182713 -0.984078449747763 "PIK3CA MUT" "LFM.A13_IC_50" 0.129951721774668 0.592095424437004 0.239147068196304 0.016683301840885 0.384705722191275 0.361344217005599 0.240784141310218 0.875707386589409 0.202492836775974 "TP53 MUT" "BAY.61.3606_IC_50" 0.0741899891895929 0.479604504293387 0.299974729507315 0.0166950594875175 0.384705722191275 0.293462046770701 0.252172622763256 0.875707386589409 0.195165936672448 "MSH2 MUT" "Vinblastine_IC_50" 0.104976772103492 0.548411007677126 -1.10063254625068 0.0167206855946214 0.384705722191275 -1.17563032407012 0.122069416171596 0.809590452621284 -0.992003922235043 "TP53 MUT" "Vinblastine_IC_50" 0.375656814185054 0.795051761241315 -0.14578490716487 0.0172499562520854 0.395079446750018 -0.291985041371692 0.157068142421772 0.837288218996252 -0.234644100124413 "ERBB2 MUT" "X17.AAG_IC_50" 0.291165719556682 0.746581806188469 -0.570909166666664 0.0173067796187027 0.395079446750018 -1.16625288411959 0.296262081572873 0.894167310052 -0.528971665168231 "PIK3CA MUT" "JNK.Inhibitor.VIII_IC_50" 0.000787312145918813 0.0384182371862911 0.567121895178203 0.0173200754056704 0.395079446750018 0.388075633804203 0.0344313579848278 0.618827479917328 0.399145816876397 "NF2 MUT" "WO2009093972_IC_50" 0.00762700383435685 0.153247558943265 -0.916219101319574 0.0173495084148752 0.395079446750018 -0.740344443854368 0.0772688199983329 0.741811190933953 -0.638559116672427 "SMO MUT" "EHT.1864_IC_50" 0.0288985489997635 0.316210068663154 1.95325758928571 0.0174723426685615 0.395711320887196 2.10047073174434 0.0345267930359913 0.618827479917328 1.82993521930498 "MYC MUT" "Bleomycin_IC_50" 0.0264512681211041 0.301171425876315 1.15797509463462 0.0174954623187073 0.395711320887196 1.01842864745672 0.187670242180649 0.851001889249827 0.701123528958171 "SETD2 MUT" "WH.4.023_IC_50" 0.0195593547008885 0.252811438707561 -5.85529535374152 0.0175109277230794 0.395711320887196 -5.23868623017004 0.156282835404984 0.837288218996252 -3.3628984741476 "VHL MUT" "CHIR.99021_IC_50" 0.00270811095764087 0.079902768819962 -1.52598589285711 0.0176430912283607 0.396836832625835 -1.1496933876652 0.0939447658156781 0.768683143653123 -0.893644183015589 "NF2 MUT" "Methotrexate_IC_50" 0.00622743854474014 0.13690420829622 1.37791092827442 0.0177012553445728 0.396836832625835 0.909951391581138 0.159501168228456 0.838901067822678 0.601788924778053 "MDM2 MUT" "PD.173074_IC_50" 0.186483960883404 0.662380873013605 -0.607231809523812 0.0177355082183357 0.396836832625835 -0.929178068736217 0.145289771853837 0.831473272394224 -0.611946292672984 "MLLT3 MUT" "GDC.0449_IC_50" 0.038435619325475 0.355199516367891 0.605588275785746 0.0177651441223366 0.396836832625835 0.615093274142352 0.0473673048573223 0.673636396626734 0.604892741776022 "MET MUT" "MG.132_IC_50" 0.0727899609409728 0.476610463578666 -3.00155462837836 0.0178294239372077 0.396836832625835 -3.47219744062789 0.372027938985865 0.913948248824328 -1.39263025053835 "MYC MUT" "GSK.650394_IC_50" 0.301313267461305 0.751119785777076 -0.340838411549518 0.0179128238672121 0.396836832625835 -0.509651393561817 0.168243238007991 0.84067330207935 -0.478017381483139 "FLCN MUT" "AUY922_IC_50" 0.00255036170913822 0.0777226391106888 2.55614702622377 0.0179158638477578 0.396836832625835 1.34826153628697 0.0202613881294566 0.533950706165295 2.41839170522912 "NOTCH1 MUT" "GDC.0449_IC_50" 0.720630119707371 0.922822998769296 -0.122735956607497 0.0179182040178989 0.396836832625835 0.750929037603412 0.496537844815568 0.933676180352967 0.250441944101906 "NOTCH1 MUT" "Embelin_IC_50" 0.0254625392291933 0.297006639954736 -0.809255365418897 0.0182032035922643 0.401475027219617 -0.697240244526128 0.0465314148583679 0.673636396626734 -0.786462546049363 "BRCA2 MUT" "BIBW2992_IC_50" 0.0485872982630794 0.392276178067643 -1.6776472614504 0.0182180425593408 0.401475027219617 -1.93824990095456 0.186569730091329 0.851001889249827 -1.04877099760926 "MYCL1 MUT" "XMD8.85_IC_50" 0.00892964833616743 0.165782266868126 1.95220704861111 0.0183592525476498 0.403349561877387 1.53781688925261 0.175189725914418 0.846738869764556 1.04021811168291 "MDM2 MUT" "Nutlin.3a_IC_50" 0.151539554335077 0.625830613280407 -0.853705428571431 0.0184317709897983 0.403349561877387 -1.28260412206221 0.105862938736802 0.788168661441703 -0.925875828361818 "RB1 MUT" "JNK.9L_IC_50" 0.042479135732331 0.370951036813011 0.356679163234175 0.0184393561673482 0.403349561877387 0.327724951663389 0.322034437116721 0.900918773778407 0.197262906314356 "NOTCH1 MUT" "IPA.3_IC_50" 0.000238173859634499 0.017925610571305 -1.91192796613191 0.0186109832661428 0.404611348633927 -1.06081982883305 0.283590574489329 0.8879937007725 -0.574702028711271 "CDKN2C MUT" "PHA.665752_IC_50" 0.0358193020033583 0.347105523744792 -1.18183221088435 0.0186539825920531 0.404611348633927 -1.31688814360925 0.142213965721437 0.831473272394224 -1.02980688770065 "EWS_FLI1 MUT" "Etoposide_IC_50" 0.00245368799998703 0.0759275370309575 -1.93304179188711 0.018662130953131 0.404611348633927 -1.04084090890633 0.718606954765317 0.964721180904622 -0.249427463061846 "MS-HL MUT" "CCT018159_IC_50" 0.0039480366450371 0.103125039542866 -0.632274564113882 0.0187563708292522 0.404611348633927 -0.482519921759083 0.00145410204610545 0.205968687037918 -0.763391769820713 "NOTCH1 MUT" "Pazopanib_IC_50" 0.0818995926527072 0.497724838837149 0.830048300802141 0.0188076596803629 0.404611348633927 0.981785458926926 0.25898041773621 0.877052916121269 0.542690852734149 "ERBB2 MUT" "Rapamycin_IC_50" 0.0511624903573544 0.403529375544995 -2.6447478 0.0188126337917494 0.404611348633927 -2.79857552671149 0.175373189503461 0.846738869764556 -1.94326378078935 "MYCN MUT" "Tipifarnib_IC_50" 0.0221699893050978 0.271944247685126 1.16280097755834 0.0188373611045617 0.404611348633927 0.810574958086763 0.614312547508635 0.950059945073224 0.29310510367957 "CDKN2A MUT" "CHIR.99021_IC_50" 2.93298417977359e-05 0.00427013647550316 -0.498534562393722 0.0188792007942389 0.404611348633927 -0.279796527128666 0.194728497525273 0.851001889249827 -0.172275006051239 "PIK3R1 MUT" "GSK269962A_IC_50" 0.104569640007398 0.547249836715204 -1.6886233349315 0.0189070723660714 0.404611348633927 -2.26833852881492 0.107217588381145 0.792785095696032 -1.65255431904676 "TSC1 MUT" "Shikonin_IC_50" 0.0258824889583814 0.299299979738783 3.22137816206901 0.019388840856353 0.413923787608825 2.84354069148252 0.0106174092970766 0.450367315182713 3.59076965483886 "VHL MUT" "LFM.A13_IC_50" 0.00393839760397144 0.103125039542866 -1.13114641915641 0.0197706145039484 0.420304331825242 -0.862605511811162 0.106692523411451 0.792410790279379 -0.684644692838211 "ERBB2 MUT" "BMS.536924_IC_50" 0.193741056796336 0.668979131185171 1.86144354421769 0.0197823680557315 0.420304331825242 2.47563071015736 0.185492948380907 0.851001889249827 1.84470522011242 "CCND1 MUT" "JW.7.52.1_IC_50" 0.240074266557159 0.711340033600749 0.930251258771931 0.0198925429238969 0.420408699512993 1.12458676484881 0.260059559551938 0.877052916121269 1.05242856394427 "FGFR2 MUT" "NVP.BEZ235_IC_50" 0.372086690398405 0.79168708611122 -0.975508264413496 0.0199509743217979 0.420408699512993 -1.84909014271204 0.113435380469319 0.799692247086917 -2.31423767938795 "ALK MUT" "Cisplatin_IC_50" 0.371132825825517 0.790604611694991 1.05024577419354 0.0199683869467847 0.420408699512993 2.37227753605628 0.380929588669153 0.915134825237766 0.991563292970125 "CCND1 MUT" "NSC.87877_IC_50" 0.0232758782347202 0.277593371444066 -0.49944654654655 0.0199766322705194 0.420408699512993 -0.507360977158019 0.0172656868036689 0.513211661128791 -0.570059430861592 "BCR_ABL MUT" "AZD7762_IC_50" 0.0992337685992207 0.5374999166548 -1.47702618355642 0.0203494158189262 0.427241517465447 1.97491083450359 0.769594292939406 0.969901216545994 0.246327323400438 "FLT3 MUT" "LFM.A13_IC_50" 0.0300383337720346 0.32084814026273 -1.201479930192 0.0204678721866208 0.428715030399479 -1.21791431381564 0.00535781277293346 0.358956332448686 -1.54302451218916 "MYCN MUT" "MG.132_IC_50" 0.00580111615578548 0.131763970791639 1.46694358604091 0.0205977520921276 0.430416799506587 1.1227970834604 0.287636170424483 0.888563331668781 0.626711812045445 "RB1 MUT" "PD.173074_IC_50" 0.00530068515007277 0.124415842357912 -0.575592634460552 0.0206460484843831 0.430416799506587 -0.419049329218795 0.00515108210343861 0.358956332448686 -0.588771614399425 "TSC1 MUT" "Temsirolimus_IC_50" 0.0653675287164244 0.457742485196035 -2.97252927134723 0.0208078380362314 0.432706839011463 -2.85131475486659 0.134682009787021 0.828635349589072 -2.28798764500457 "BRCA1 MUT" "AZD.2281_IC_50" 0.45971605200905 0.828966839128293 -0.555568073122525 0.0208533416391066 0.432706839011463 -1.31119285653936 0.218475687077969 0.861199545911868 -0.809433218729099 "MYCL1 MUT" "Temsirolimus_IC_50" 0.0330522527175828 0.335087963909649 1.72805594577735 0.0209720637652297 0.43370391411865 1.42378040520977 0.0582952021859269 0.70215997387469 1.59685204492483 "ALK MUT" "Bexarotene_IC_50" 0.0432337052685449 0.374123126127403 2.29579585913045 0.0209990635143587 0.43370391411865 2.33701162866139 0.229183914861304 0.868145256417768 1.83971892314836 "TET2 MUT" "RDEA119_IC_50" 0.00705198011708066 0.146642555554916 3.63648513492054 0.0211405278801467 0.435612594207849 2.84363238508486 0.0487859356832651 0.679896345274018 2.80186150691445 "STK11 MUT" "Shikonin_IC_50" 0.00638514511161741 0.138397665983245 1.15934187992833 0.0213109451969425 0.437003916247973 0.825284834952203 0.0147813135576085 0.490024700267999 1.07637133896299 "CCND1 MUT" "BIRB.0796_IC_50" 0.259066088270381 0.723189643810247 -0.281052366533862 0.0214551868359114 0.437003916247973 -0.551372177067231 0.254026865750438 0.875707386589409 -0.303550378603939 "VHL MUT" "Bosutinib_IC_50" 0.0665809364507947 0.458731804980223 -1.17275444894026 0.0215501861301438 0.437003916247973 -1.20551352540603 0.0680231427818085 0.719539038493615 -1.1703236623768 "CDKN2A MUT" "AZD.0530_IC_50" 1.67493214718158e-05 0.00256466765502062 -1.03377961268497 0.0215706054255597 0.437003916247973 -0.503607450854601 0.0805104662653587 0.741811190933953 -0.461450835309945 "MYC MUT" "LFM.A13_IC_50" 0.0166154046911573 0.235721100738288 0.418864419475657 0.0216099776761418 0.437003916247973 0.382087583060871 0.190754185147019 0.851001889249827 0.241253277850315 "KDM6A MUT" "AS601245_IC_50" 0.0252733181943194 0.2955449111082 -0.893927241349784 0.0216122530866704 0.437003916247973 -0.738767679346637 0.0118669946345331 0.459749370120074 -1.05165653713042 "HRAS MUT" "SL.0101.1_IC_50" 0.310385631760427 0.757046299071613 -0.506670116054156 0.0216207830346109 0.437003916247973 -1.0003414445345 0.202735299924785 0.852959543285214 -0.610945734334139 "MYC MUT" "AZD.2281_IC_50" 0.07551265417051 0.480779116570693 -0.442773825739018 0.0216224281773419 0.437003916247973 -0.432870106758766 0.0542318018488422 0.697305726351784 -0.44208028300074 "PTEN MUT" "AZD.2281_IC_50" 0.0362549615656467 0.348463542926957 -0.395620567850542 0.0216542188978167 0.437003916247973 -0.335435219019938 0.0658999983157874 0.711992560878964 -0.331477567582554 "FGFR2 MUT" "Shikonin_IC_50" 8.57871774434007e-05 0.00846528803194268 4.0044526453287 0.0217001156474897 0.437003916247973 2.01034146590872 1.33205217795564e-05 0.00591497769621204 4.98138818106374 "BRAF MUT" "Vinorelbine_IC_50" 0.0730222530499552 0.476846050982832 -0.513655844919785 0.0217601576186089 0.437221628531371 -0.532285270851158 0.0987816640408965 0.774133667469059 -0.556101518916689 "MLL_AFF1 MUT" "Cyclopamine_IC_50" 0.00283451792737992 0.0830803752906306 -3.10744280821916 0.0219892520235264 0.43967028665604 -2.24149323654997 0.00688145580499252 0.379591360274153 -2.83299075454697 "CCND1 MUT" "Nutlin.3a_IC_50" 0.00133680121301839 0.0536789144563151 1.22123522699387 0.0219896897965161 0.43967028665604 0.80363197217616 0.0886532636438953 0.758159640835928 0.680356664169087 "TP53 MUT" "TW.37_IC_50" 0.044883798920112 0.378674422837037 0.27079789980023 0.0220305458351467 0.43967028665604 0.295578216125719 0.252000558181234 0.875707386589409 0.159783843629849 "MS-HL MUT" "Sorafenib_IC_50" 0.0358400816658005 0.347105523744792 0.672046878784799 0.0221491396069706 0.440442201262396 0.706873022822268 0.0082649435553185 0.398918281058606 0.972395565314652 "TP53 MUT" "NU.7441_IC_50" 0.0393816904000336 0.360565765404844 0.275634885308123 0.0221684116613322 0.440442201262396 0.281945074482981 0.486122816345541 0.933639405738697 0.0965973202813911 "FLT3 MUT" "PAC.1_IC_50" 0.00361091139689186 0.0977698296213311 -2.51124694764403 0.0223230103553447 0.44252378340584 -1.66578926171919 0.028365620412362 0.595164254286719 -1.83867790169745 "PIK3CA MUT" "PD.0325901_IC_50" 0.0238641590134627 0.282638654010318 0.775352787141534 0.0224750161508169 0.444544807205802 0.742060970499338 0.00935141975319873 0.428092571279165 0.853458672866105 "KRAS MUT" "WO2009093972_IC_50" 8.6359909096013e-07 0.000201832198074129 0.944301883625727 0.0225444257963685 0.44492676777233 0.420487701307938 0.00189417615373701 0.243799687265774 0.685760507817575 "ALK MUT" "NVP.TAE684_IC_50" 0.0467613347359768 0.38471575603508 -2.44919454729731 0.0226273227072866 0.44557262297874 -2.32469440880681 0.00663156795848853 0.370691368090687 -3.9036394820975 "CDKN2a(p14) MUT" "ABT.263_IC_50" 0.0602987498198623 0.443886947376523 0.370153786145493 0.0226832703479574 0.445686114956216 0.421469175258184 0.797701500803383 0.976360691959787 0.0490855757545062 "NF2 MUT" "AKT.inhibitor.VIII_IC_50" 0.326915604789953 0.76909602281843 0.348788867583397 0.0228407101751357 0.44778884561894 0.698833059572407 0.0755360299492131 0.741811190933953 0.664856390052204 "BRCA2 MUT" "MS.275_IC_50" 0.249392593779252 0.71580012538195 -1.79074944709899 0.022943882469631 0.448820749367385 -2.93552338655407 0.32927914581707 0.902810042912437 -1.59923467955231 "RB1 MUT" "Bosutinib_IC_50" 0.107054423208698 0.551794991672845 0.402651092493203 0.0231941169681271 0.452718577569091 0.478118531191685 0.74226968467188 0.96672489654949 0.0842265968032324 "EZH2 MUT" "BIRB.0796_IC_50" 0.0227970077257962 0.276060433616212 -1.24098980842911 0.0233669252791837 0.452950805613533 -1.17836228820912 0.0138835157891734 0.482141194305023 -1.32171273970292 "CTNNB1 MUT" "VX.702_IC_50" 0.209524323587879 0.683860903264959 -0.527730113960118 0.0234484071178427 0.452950805613533 -0.778768309038825 0.381534558619435 0.915134825237766 -0.373905365527976 "NF1 MUT" "AZ628_IC_50" 0.278502503141017 0.736660995953974 0.828595765969012 0.0234549025820473 0.452950805613533 1.29012169384053 0.366752619894182 0.913948248824328 0.678637136059714 "SETD2 MUT" "FTI.277_IC_50" 0.0157993745300096 0.22780750573449 -1.87907774655176 0.0234821750942603 0.452950805613533 -1.61666364996724 0.0615174612662339 0.702860976445846 -1.38400180465886 "BCR_ABL MUT" "Cytarabine_IC_50" 0.171297063779346 0.649721929411943 -1.36106638380954 0.0235009605484999 0.452950805613533 -2.07736079782493 0.891866036867367 0.988301482344111 -0.129078268213461 "BRAF MUT" "SB.216763_IC_50" 0.148828354183103 0.623758666116159 -0.301881074154411 0.0235120280810538 0.452950805613533 -0.489684213386262 0.564144527925353 0.949294892873838 -0.137645987072971 "CDKN2a(p14) MUT" "PLX4720_IC_50" 0.00109353575108515 0.04784084239107 -0.551389137829372 0.0235857869994882 0.453131635816167 -0.353727022269534 0.199934285221505 0.851001889249827 -0.220662427369505 "EZH2 MUT" "BMS.509744_IC_50" 0.9813647339518 0.996512714638228 -0.0203687030716724 0.0236366050610484 0.453131635816167 -1.46103688648242 0.925657183601154 0.994026707431102 -0.0916730498636933 "MLLT3 MUT" "CCT007093_IC_50" 0.0458104896688131 0.382012167839182 -0.513287471198159 0.0236744824928163 0.453131635816167 -0.581037829765601 0.13745977449408 0.831473272394224 -0.396158719919152 "EZH2 MUT" "ABT.263_IC_50" 0.0439096640463683 0.375324087002692 -2.19607446078432 0.0238367395171475 0.454570438357544 -2.20109434330108 0.076100782104757 0.741811190933953 -1.67410200108447 "FBXW7 MUT" "RO.3306_IC_50" 0.0146428778070899 0.219880326380618 0.779609283074658 0.0238520239021073 0.454570438357544 0.691244474134533 0.076931894728044 0.741811190933953 0.604068975687976 "MLLT3 MUT" "VX.680_IC_50" 0.241724442372211 0.711340033600749 -0.989052486013981 0.0241058920083856 0.457669769354229 -1.22785207402921 0.421333022247495 0.922428741067589 -0.740382390266031 "SMAD4 MUT" "BIBW2992_IC_50" 0.0664415971284942 0.458546662429304 -0.686615109561753 0.0241177178310752 0.457669769354229 -0.826151046357296 0.597945685253491 0.949294892873838 -0.193823306427577 "IDH1 MUT" "FTI.277_IC_50" 0.017741707162139 0.244548698860748 -1.84610995517244 0.0243391764921249 0.460887476389257 -1.58871859697791 0.044173861952284 0.659657620288543 -1.49710392924956 "CDKN2A MUT" "PD.0325901_IC_50" 0.000117119673391178 0.0107498600656142 -0.766398251357715 0.0244541583422433 0.461393159320682 -0.438491615485136 0.33170466952182 0.902810042912437 -0.194422251904021 "PIK3CA MUT" "PF.562271_IC_50" 0.243172814485777 0.712490868125953 0.255766946759261 0.0244697869654364 0.461393159320682 0.40797227418337 0.222456166835346 0.865601665610206 0.288092811861814 "APC MUT" "Vorinostat_IC_50" 0.143987586135059 0.617457147496601 0.347695254166668 0.0245337541797335 0.461619217945367 -0.429563316368408 0.974331366632267 0.99742775226181 0.0085569178429157 "NOTCH1 MUT" "PAC.1_IC_50" 0.00112653879562835 0.0485669468154143 -1.4187775801025 0.0247135281512013 0.46401869664021 -0.838279901206257 0.306429125291359 0.896682870760742 -0.475582331295177 "PIK3CA MUT" "RDEA119_IC_50" 0.0191474591751344 0.251179593699216 0.836871142738205 0.0251868828554078 0.470681072534139 0.728939164413854 0.0169297499784353 0.513211661128791 0.798502417194756 "KDM6A MUT" "Gefitinib_IC_50" 0.00719384839384894 0.147954795123546 -1.10411090058479 0.0252148971622369 0.470681072534139 -0.829354523546307 0.013700501110486 0.482141194305023 -0.944159313535266 "PTEN MUT" "AICAR_IC_50" 0.677430387026738 0.908720747099578 0.0890552432432429 0.0252273607168394 0.470681072534139 0.438615900070238 0.73462927238757 0.96672489654949 -0.0756477833900662 "MSH6 MUT" "RO.3306_IC_50" 0.0648574062052134 0.456953003353045 1.11251982939631 0.0253866351345934 0.47160994812281 1.28474166377541 0.0616330105747131 0.702860976445846 1.11765391908723 "MYCL1 MUT" "FTI.277_IC_50" 0.0175134983690554 0.243027154711845 0.833027248251739 0.0253964449306209 0.47160994812281 0.713698327793173 0.664271336397588 0.959206771190239 0.158135276587172 "CCND3 MUT" "PD.0325901_IC_50" 0.0566650728245678 0.428656313249563 3.02833580792083 0.0254364559341094 0.47160994812281 3.32899646848541 0.00968765801090444 0.438959646912461 3.57149373032265 "FGFR2 MUT" "Cytarabine_IC_50" 0.0212819414809079 0.266579580101471 3.22881999240985 0.0255758299610993 0.473206137259423 2.38598672819846 0.0551131571142193 0.697305726351784 3.5141716736141 "RB1 MUT" "SB590885_IC_50" 0.454378032824927 0.828966839128293 -0.201243668869793 0.0256913706539777 0.473861173133253 -0.51537913513538 0.035750970562897 0.627231492353831 -0.549879810314771 "MSH2 MUT" "Temsirolimus_IC_50" 0.393817234952736 0.803073858340542 0.739695628899834 0.0257179467909276 0.473861173133253 1.47580197121133 0.256295843175216 0.875707386589409 0.940855301222391 "RUNX1 MUT" "Etoposide_IC_50" 0.163439127218309 0.638865708109947 1.5317838613518 0.0257714151262418 0.473863225126611 1.59120106847042 0.655105769582477 0.958313128388245 0.517114073367795 "MS-HL MUT" "BAY.61.3606_IC_50" 0.000444772175360465 0.0275880423284081 -0.856761319867633 0.0258651282651022 0.473920807492233 -0.381718946337423 0.0174041264827737 0.513211661128791 -0.608367267954563 "MDM2 MUT" "CCT018159_IC_50" 0.337909257114116 0.775607549993217 -0.433407209302328 0.0259148096212428 0.473920807492233 -0.935586967083858 0.374101508516372 0.913948248824328 -0.403994268864042 "KDM5C MUT" "PF.562271_IC_50" 0.06735280864572 0.460513103960953 -1.40661488927338 0.0259814531984137 0.473920807492233 -1.39878630148338 0.0522487374794883 0.690946762417053 -1.45993130098602 "MSH6 MUT" "Erlotinib_IC_50" 0.241102627042972 0.711340033600749 1.42879665454546 0.0260941734573492 0.473920807492233 2.43455756678157 0.494579795362111 0.933639405738697 0.822386831347895 "SMAD4 MUT" "Etoposide_IC_50" 0.221292684901746 0.693717025983906 -0.570316886948934 0.0261873891060801 0.473920807492233 -0.691422408479515 0.0467561308818718 0.673636396626734 -0.94220672696101 "APC MUT" "OSI.906_IC_50" 0.0201508613562928 0.257496114683793 -0.872382746425606 0.0262358483226517 0.473920807492233 -0.818699630840986 0.0256798626001502 0.578646945543191 -1.02421958146481 "CDKN2C MUT" "Bleomycin_IC_50" 0.0179118961961122 0.245008564936728 2.48486671957671 0.0263088374476731 0.473920807492233 1.89599675035796 0.0297615293453357 0.59799127175549 2.62306152828853 "FBXW7 MUT" "AUY922_IC_50" 0.383494634801887 0.798569876743396 0.358610061097457 0.0263799484256458 0.473920807492233 0.611718119542843 0.208258514963296 0.853446327418758 0.514449281517155 "BRCA2 MUT" "Mitomycin.C_IC_50" 0.221188959850022 0.693711036770013 -1.11183179042616 0.0264100302556476 0.473920807492233 -1.57971773267221 0.0638873619018762 0.70585538398383 -1.65158364633949 "SETD2 MUT" "BI.D1870_IC_50" 0.0363441644997318 0.348943270186073 2.38138013142864 0.0264449003436407 0.473920807492233 2.19279458811327 0.0417029592809057 0.658180729724545 2.19777181742159 "VHL MUT" "AZ628_IC_50" 0.36935355519523 0.789535578103719 1.40465132309443 0.0264481824041341 0.473920807492233 2.58780149446643 0.299971648433989 0.894167310052 1.4546049112624 "MYC MUT" "CEP.701_IC_50" 0.028698511471884 0.314656148619508 0.65534689944022 0.026487633408054 0.473920807492233 0.48982157959719 0.0261225297706891 0.584368228950855 0.631956549576811 "AKT2 MUT" "NU.7441_IC_50" 0.0311361747169238 0.326856226549646 1.26350468654739 0.0265095463439299 0.473920807492233 1.13953596637021 0.13172842928721 0.824721122422311 0.858632835232948 "CTNNB1 MUT" "AZD7762_IC_50" 0.2002811820261 0.674012093366938 0.642382110146671 0.0265303575561374 0.473920807492233 0.869926208193117 0.342239333326496 0.907180409180092 0.473721902809606 "CDKN2A MUT" "Vinblastine_IC_50" 0.000135722003488664 0.0119341298315131 -0.59085293840528 0.0265749985509663 0.473920807492233 -0.259882144690059 0.00450196289297712 0.347668977848085 -0.470664010444174 "MYCN MUT" "PD.0332991_IC_50" 0.0332741021673223 0.336031521689191 -0.933826516452076 0.0266452554165865 0.474221469648708 -0.802847363808773 0.00346765412344562 0.307545333416453 -1.45441374811089 "MYCN MUT" "Salubrinal_IC_50" 0.00878464214092825 0.164675551415839 1.0145436392075 0.0268109721166319 0.476216486735617 0.7290691995524 0.118921714372133 0.80678720253446 0.716536989233096 "RB1 MUT" "Methotrexate_IC_50" 0.844963709223402 0.960835173061848 -0.0634616835703276 0.0269266746321482 0.476978778557718 0.560387238745382 0.191351631774872 0.851001889249827 -0.369581327251841 "FLT3 MUT" "Mitomycin.C_IC_50" 0.00200233342798916 0.0663534446789991 -3.42128972774876 0.0269613046769479 0.476978778557718 -1.9487949610626 0.0226620800569833 0.559060924961302 -2.47395024244684 "RUNX1 MUT" "Epothilone.B_IC_50" 0.217555783332363 0.689975030887399 1.29194072482519 0.0270745183889671 0.477654788498175 1.31639980852657 0.642500975751856 0.955787464933372 0.527411044237556 "TET2 MUT" "ATRA_IC_50" 3.18370860274135e-05 0.00447438868476652 -4.12086571383053 0.0271070840449364 0.477654788498175 -1.75688485668315 0.0889831843843697 0.758159640835928 -1.83018947244247 "MLLT3 MUT" "AZD6244_IC_50" 0.0733217356991994 0.477424621155859 -1.05052436723163 0.0273799158000711 0.479875819073463 -1.17238936062453 0.722969176439036 0.965402608571648 -0.198306723220489 "EWS_FLI1 MUT" "Doxorubicin_IC_50" 0.00654962428569431 0.140500515172104 -1.38266523072362 0.0274398503639833 0.479875819073463 -0.744323701765046 0.550419199380153 0.947060194029534 -0.331181538581113 "EZH2 MUT" "BI.2536_IC_50" 0.00842096097660051 0.161177919037045 2.99056816382253 0.0274806953023124 0.479875819073463 1.48577184483485 0.00531967270531982 0.358956332448686 3.75271987049139 "NRAS MUT" "Bryostatin.1_IC_50" 0.0471144089546989 0.384922051833884 -0.400370750556295 0.0274832451534408 0.479875819073463 -0.432640481382473 0.0248526870837336 0.571841777133554 -0.493835019044283 "PIK3CA MUT" "Epothilone.B_IC_50" 0.0221477028327703 0.271944247685126 -0.761583483181081 0.0275149556639042 0.479875819073463 -0.421780690245661 0.0316465983981359 0.617683870699155 -0.765889780627114 "MYC MUT" "Bortezomib_IC_50" 0.0224853386235582 0.274192156774193 1.06930321372693 0.0275573322517133 0.479875819073463 0.85630102825886 0.159904232105873 0.838901067822678 0.662823292912151 "ALK MUT" "JW.7.52.1_IC_50" 0.0908164544830737 0.516289683341382 2.28460485494881 0.0277433617489125 0.480006117955699 1.81090710059623 0.267417609312848 0.877052916121269 1.78051167968337 "RUNX1 MUT" "Vinorelbine_IC_50" 0.105556547183067 0.549178497675936 1.47028757885614 0.0277953678892543 0.480006117955699 1.46443324065861 0.766744437936224 0.969901216545994 0.294545809632329 "PTEN MUT" "Tipifarnib_IC_50" 0.213938660310808 0.688117861819268 0.326592396245816 0.0279165305236004 0.480006117955699 0.392546859803025 0.385050748905904 0.915331032347709 0.243305177994433 "RUNX1 MUT" "AS601245_IC_50" 0.302815451393998 0.752537231223384 -0.833332258741268 0.0279996668650402 0.480006117955699 -1.41734523417333 0.265733138812104 0.877052916121269 -0.988342852062509 "KDM6A MUT" "AZD7762_IC_50" 0.021244012072762 0.266480326579378 -1.04271131568003 0.0280112863078857 0.480006117955699 -0.784879672207654 0.0308250066613994 0.608744701904523 -0.920428749550433 "NRAS MUT" "VX.702_IC_50" 0.0225071593613767 0.274192156774193 -0.58155715525341 0.0280194613597862 0.480006117955699 -0.469382062418805 0.0639808111819596 0.70585538398383 -0.500667997743844 "FLCN MUT" "DMOG_IC_50" 0.0023268886138507 0.0735422758442113 2.43821830155977 0.0280285622130445 0.480006117955699 1.58334431516931 0.179587718837201 0.848722027112292 1.3070288759034 "EP300 MUT" "KU.55933_IC_50" 0.0503810521109874 0.399494753390785 -1.41948550724639 0.028042485684871 0.480006117955699 -1.423336367441 0.0418215409099831 0.658180729724545 -1.4458360482622 "MYCN MUT" "AKT.inhibitor.VIII_IC_50" 0.00221456896440474 0.0710021190356624 1.13833467804058 0.0280571320672153 0.480006117955699 0.715631121963719 0.424609840616457 0.922428741067589 0.336315429807401 "ERBB2 MUT" "XMD8.85_IC_50" 0.0542693291716385 0.41656517923364 1.75858406896552 0.0282360019139008 0.480006117955699 1.76268904542804 0.0657656260877658 0.711992560878964 1.71549648969385 "BRAF MUT" "GDC0941_IC_50" 0.0236968091060597 0.281352087795343 0.606268276524311 0.0282603984628693 0.480006117955699 0.517528418546106 0.294478693679837 0.894167310052 0.330347139895854 "TET2 MUT" "BMS.536924_IC_50" 0.303889519659693 0.753445791205397 -1.47340849659866 0.0284046898910044 0.480006117955699 -2.34100132131862 0.0753813139887234 0.741811190933953 -2.94032000228294 "PIK3CA MUT" "GSK269962A_IC_50" 0.0591266351645855 0.439785298908445 1.23373903575298 0.0284093539212566 0.480006117955699 1.33851135789036 0.249234974369641 0.875707386589409 0.82370136475244 "EWS_FLI1 MUT" "GSK.650394_IC_50" 0.980682626235624 0.996332002460735 -0.0131834911032025 0.0284364183980719 0.480006117955699 0.819143641646811 0.190496879807111 0.851001889249827 0.809858027655836 "RB1 MUT" "PAC.1_IC_50" 0.145979626570397 0.619919550890177 0.327948604459469 0.0284732733595129 0.480006117955699 0.422941632403841 0.260690182907203 0.877052916121269 0.277743812208129 "NOTCH1 MUT" "Bortezomib_IC_50" 0.264607588092607 0.72664811065258 -0.77102361881977 0.0284740969853136 0.480006117955699 -1.28182807965122 0.0142146118055102 0.48705019394989 -1.84942855853271 "CDKN2a(p14) MUT" "PHA.665752_IC_50" 0.00384647204764775 0.102277000763951 -0.485510588085928 0.0284836419505296 0.480006117955699 -0.384977840353465 0.165623883916669 0.84067330207935 -0.272144823260757 "MSH6 MUT" "Z.LLNle.CHO_IC_50" 0.070516008397603 0.469481816691404 1.64837929109591 0.0286927904321635 0.482614908765236 1.83547992552465 0.0690234469607419 0.722874094880129 1.60259758905696 "AKT2 MUT" "AKT.inhibitor.VIII_IC_50" 0.00805923517451623 0.158000149193993 -1.60854872273294 0.0291087598785248 0.488686004690319 -1.13482701985443 0.0188863549488418 0.516564999115032 -1.40983171128145 "CDH1 MUT" "DMOG_IC_50" 0.00815952586706594 0.158981783709833 1.58590459569518 0.0292275664519888 0.488787298145592 1.19507852230014 0.0531943607663883 0.694899360941831 1.17233370084821 "NRAS MUT" "Mitomycin.C_IC_50" 0.0104285084928933 0.181599184167423 -0.90693208758344 0.0293243907819242 0.488787298145592 -0.625822765812164 0.101751093708019 0.775001254906449 -0.64497701937537 "TP53 MUT" "Shikonin_IC_50" 0.021667133429189 0.269127009768709 0.411038698001483 0.0294177961806552 0.488787298145592 0.341212697344012 0.0273401159274654 0.588860092297546 0.415780165477712 "MYC MUT" "Shikonin_IC_50" 0.00739268687061036 0.150245705138803 0.85652658482596 0.0294362207777498 0.488787298145592 0.59030936368176 0.0286964861299554 0.597512888074595 0.721744652754979 "SMARCA4 MUT" "Bosutinib_IC_50" 0.226601427228143 0.699276507734018 -0.693349257253385 0.029482307333597 0.488787298145592 -1.01841088035282 0.0179340481771031 0.513211661128791 -1.42971845639258 "AKT2 MUT" "JNK.Inhibitor.VIII_IC_50" 0.0896499425199498 0.514272513671442 -0.795105841330782 0.0295393499635078 0.488787298145592 -0.970983765462212 0.0633523509990663 0.70501719149803 -0.882304228549276 "TP53 MUT" "AICAR_IC_50" 0.00739301578039151 0.150245705138803 -0.426279190751445 0.0295517501197019 0.488787298145592 -0.321713078964475 0.0154951933472105 0.498597145349916 -0.395707802290284 "CDH1 MUT" "VX.702_IC_50" 0.0617137755166763 0.448143941425676 -0.995846481660242 0.0295550927940753 0.488787298145592 -0.960315641501581 0.275078314605383 0.883780956691668 -0.582318737207204 "MLH1 MUT" "AZD6482_IC_50" 0.0693046900061874 0.466280108629924 -1.04038831842105 0.0297199882599833 0.490087320277749 -1.06243202043553 0.0210893248004479 0.544460155676679 -1.29721086931027 "NF1 MUT" "Metformin_IC_50" 0.00515251085355611 0.123340832588765 0.874102964426871 0.0297440677434644 0.490087320277749 0.637002064153029 0.0691195358761509 0.723027795189748 0.592827029468879 "FBXW7 MUT" "Metformin_IC_50" 0.0163635277683421 0.233354840019847 -0.735119698665513 0.0298263935994607 0.490533706586686 -0.622306490597846 0.285739531830619 0.8879937007725 -0.340317777021777 "FGFR2 MUT" "AP.24534_IC_50" 0.240633007472549 0.711340033600749 -1.62859057093424 0.0299376028074028 0.49145258878474 -2.7462640083353 0.0564192225152278 0.697813103075383 -2.86729645021768 "MLH1 MUT" "PD.173074_IC_50" 0.0114840000445889 0.190612249988411 -1.10635871679018 0.0301172063526384 0.493302893945958 -0.823239325530339 0.0424223127235159 0.658180729724545 -0.825784560400327 "BCR_ABL MUT" "Bosutinib_IC_50" 5.89475499144257e-05 0.00662674925050652 -3.59586481644363 0.0301614087842197 0.493302893945958 -1.65558432940272 0.0100216514861852 0.44724767260709 -2.20619530490431 "KRAS MUT" "BX.795_IC_50" 1.05753998523955e-05 0.0017720778507382 0.846498615618033 0.0302335007555676 0.493573015092273 0.34360658367719 0.0835435590790214 0.746428921711055 0.347660408212856 "EP300 MUT" "NU.7441_IC_50" 0.0840988467291022 0.500926799330085 -1.42899833201582 0.0304020524340447 0.494660588375232 -1.57382602322468 0.0597850760836628 0.70215997387469 -1.49007273155561 "KIT MUT" "Bosutinib_IC_50" 0.123759324636818 0.583699714338599 1.38686980114722 0.0304949170574424 0.494660588375232 1.60056767134757 0.333899942418535 0.903569160603576 0.812623993494374 "SMO MUT" "WO2009093972_IC_50" 0.0322522670767589 0.331135703940689 2.33328404608295 0.0305691237554103 0.494660588375232 2.1050259817383 0.059830505664996 0.70215997387469 2.01711000095372 "MDM2 MUT" "CEP.701_IC_50" 0.944454676344657 0.990147156460271 -0.0410737928709046 0.0305775014509603 0.494660588375232 -0.934728652215168 0.70052866384432 0.961100601384891 -0.204524016751551 "MDM2 MUT" "CHIR.99021_IC_50" 0.0797841177094804 0.490694424776936 0.800747150349651 0.0305786131086592 0.494660588375232 0.934900945858516 0.0199607165903924 0.528982201860999 1.02177528031673 "NOTCH1 MUT" "Z.LLNle.CHO_IC_50" 0.0246182013646355 0.289581783204407 -1.2483426720893 0.0308727979016649 0.495499291485935 -1.15253141284676 0.0844621112408536 0.747749574262573 -1.07785047253117 "APC MUT" "GSK269962A_IC_50" 0.0292484836509906 0.316389504633919 1.54236657342658 0.0309255832270267 0.495499291485935 1.47667327722542 0.413584261866424 0.921714070263062 0.701191208848733 "FBXW7 MUT" "CI.1040_IC_50" 0.0501167583967569 0.398392473033632 -0.745579166133624 0.0309591347708246 0.495499291485935 -0.735632536131564 0.217382327332358 0.860928912580141 -0.439381189347969 "CTNNB1 MUT" "Bortezomib_IC_50" 0.011384541297029 0.189692516433236 -2.33747159195404 0.0309888485842849 0.495499291485935 -1.60921853261821 0.00715395627454143 0.381508554648877 -2.62015120348051 "VHL MUT" "Vinorelbine_IC_50" 0.195031539537126 0.670441006096806 0.933448144599286 0.030990741940747 0.495499291485935 1.14663653571927 0.725123506655877 0.965402608571648 0.269937068497224 "KRAS MUT" "AZD7762_IC_50" 0.360124460618081 0.786601117838604 0.192735390971894 0.0310892649780432 0.495499291485935 -0.377583787794554 0.88921814582389 0.988301482344111 0.0310461470137619 "CDH1 MUT" "AG.014699_IC_50" 0.0118773205881009 0.195700341638078 1.37329308616782 0.0311486621796939 0.495499291485935 1.04641588246966 0.105524900283616 0.788168661441703 0.895754402361716 "SETD2 MUT" "CCT018159_IC_50" 0.0299349718198009 0.320690572655792 2.17061940639271 0.0311771601859478 0.495499291485935 2.02729245812785 0.0359934865873505 0.62924833539815 2.11542139364873 "KDM5C MUT" "WZ.1.84_IC_50" 0.0329734071966531 0.335007231085929 -1.79170609589041 0.0312122996335915 0.495499291485935 -1.51569898504731 0.0542390712856735 0.697305726351784 -1.53142653923623 "MS-HL MUT" "Imatinib_IC_50" 0.0460654460198596 0.382890359661179 0.469772654440154 0.031235703218595 0.495499291485935 0.50127311102919 0.00654762803322624 0.370691368090687 0.763039362807114 "CDKN2a(p14) MUT" "AZD.0530_IC_50" 1.19363618146918e-05 0.00192739689593232 -1.0791880466954 0.0312441845774264 0.495499291485935 -0.487338275199475 0.0230438259960966 0.562231369976192 -0.604647772538046 "SMAD4 MUT" "NU.7441_IC_50" 0.0121078386072552 0.19730222875419 0.720456929765885 0.0313546267306089 0.496364420667625 0.560048716087967 0.116263702508172 0.802355750183445 0.463262074219778 "MYC MUT" "GDC.0449_IC_50" 0.063361726526337 0.450893824743909 -0.372744854166663 0.0314942122927484 0.497687009558538 -0.385620740495614 0.193642944327427 0.851001889249827 -0.271141740424502 "MLLT3 MUT" "RDEA119_IC_50" 0.0814499832730202 0.495658818759118 -1.00395797046818 0.0317115862077537 0.499502933792341 -1.116346944921 0.481321374096403 0.930646356603431 -0.366581127629507 "MYCL1 MUT" "A.443654_IC_50" 0.438138592799517 0.824038297893374 -0.648219326436786 0.0317216140816215 0.499502933792341 -1.17766312086629 0.199840671836098 0.851001889249827 -1.13972268626746 "ALK MUT" "PD.0332991_IC_50" 0.00525086822877718 0.12435456197272 -3.17340051170794 0.0318503846335553 0.500454418187997 -1.95659498530297 0.00540938815720256 0.358956332448686 -3.63860006780997 "FGFR2 MUT" "Bleomycin_IC_50" 4.68060322142724e-05 0.00577339405687434 6.6887808027924 0.0318947416613452 0.500454418187997 2.92923905804479 0.00341648110915297 0.307545333416453 5.35868443572274 "EZH2 MUT" "GW843682X_IC_50" 0.0111589159675903 0.187804952756533 3.09846553754267 0.0320437643618516 0.501710951704638 1.34876894459239 0.00565858422957055 0.358956332448686 4.00662000197846 "FBXW7 MUT" "FTI.277_IC_50" 0.0347652822982805 0.344203424850646 0.504636962012981 0.0320878077432986 0.501710951704638 0.467785704940753 0.0519933217159533 0.690213288728522 0.458441203469183 "EWS_FLI1 MUT" "S.Trityl.L.cysteine_IC_50" 0.0232153694822233 0.277593371444066 1.44912135470492 0.0322398400999479 0.503201815148937 0.812741343587523 0.156873791389563 0.837288218996252 1.06221562271807 "MLH1 MUT" "VX.702_IC_50" 0.00661234682793339 0.140825544793469 -1.23575432127098 0.0322964795220014 0.503201815148937 -0.807306813347813 0.0647639336756015 0.710962292920911 -0.790116901752399 "BRCA1 MUT" "S.Trityl.L.cysteine_IC_50" 0.457432561828737 0.828966839128293 -1.09968735714286 0.032360580163992 0.503317534914909 -1.71982930539778 0.43632957628638 0.922569292988365 -1.18828796455232 "MLL_AFF1 MUT" "SB.216763_IC_50" 0.00219042952220002 0.0704826253139796 -3.14382395711501 0.0324391761078572 0.503657907366923 -2.16440601009813 0.00408973334622618 0.336304831924395 -2.88413654275864 "CDH1 MUT" "BIBW2992_IC_50" 0.00646700555592483 0.139740818350775 -1.83348415571014 0.0327407922563575 0.507337453422493 -1.39149705984707 0.0394127675414169 0.64992634601437 -1.37913686103822 "TSC1 MUT" "NVP.BEZ235_IC_50" 0.152591085198895 0.625940613233895 -1.56238251888666 0.0327904175503334 0.507337453422493 -1.68441891891993 0.176840431916661 0.848618686837376 -1.39892778302086 "CDKN2a(p14) MUT" "GSK269962A_IC_50" 0.00018436018589717 0.0150211267059887 -1.0628706591975 0.0328949172625027 0.507911319488675 -0.612800084776654 0.0128003533618459 0.4776467991872 -0.806726955037065 "NRAS MUT" "IPA.3_IC_50" 0.0234897218505784 0.279266693112433 -0.747675515798838 0.0329901322794169 0.507911319488675 -0.60939934138097 0.755558862283222 0.969901216545994 -0.109398837115561 "FBXW7 MUT" "Obatoclax.Mesylate_IC_50" 0.0191127172866402 0.251111880766628 -1.17047058280097 0.0330445383190951 0.507911319488675 -0.780776629643144 0.0345612464856429 0.618827479917328 -1.05371102200283 "SETD2 MUT" "AZD8055_IC_50" 0.255364702457566 0.720311238267775 1.14326936237625 0.0330562709902549 0.507911319488675 1.67728500395641 0.220950908631964 0.864815645798718 1.19070785349062 "AKT2 MUT" "RDEA119_IC_50" 0.0487836958279544 0.393504089598604 2.06756431872508 0.0331436454822743 0.508202625591557 2.01373382479236 0.0924571247338174 0.76758746139711 1.52486221431851 "EWS_FLI1 MUT" "Midostaurin_IC_50" 0.969827017398883 0.995036245554468 0.0184886402116401 0.0333049606277895 0.508202625591557 0.877523165083842 0.553728464571428 0.947891768284281 0.30012312401283 "CDH1 MUT" "Shikonin_IC_50" 0.535100328665593 0.859397667178979 -0.426166514252473 0.0333075296694265 0.508202625591557 -1.24665101888587 0.222207378966241 0.865601665610206 -0.875781394663152 "KDM6A MUT" "JNJ.26854165_IC_50" 0.0127965954522039 0.204033328924638 -0.795432841732987 0.0333544362014016 0.508202625591557 -0.635149422811975 0.00637610020930042 0.370691368090687 -0.82607661540194 "NF2 MUT" "Gemcitabine_IC_50" 0.0534176792495154 0.413242516911974 -1.7373767088044 0.0333613479022495 0.508202625591557 -1.28619311447701 0.482361513769114 0.931217392063982 -0.638932931168619 "PIK3R1 MUT" "BX.795_IC_50" 0.0177608276956629 0.244548698860748 1.34604213934425 0.0334263358133463 0.508320699243713 0.932061913157764 0.0680154573368395 0.719539038493615 0.910325036693536 "MLLT3 MUT" "SB590885_IC_50" 0.350480118815648 0.784966682190403 0.431663614583335 0.0335367003685834 0.509127240980152 0.819967908462108 0.267405603546548 0.877052916121269 0.475476772187594 "PIK3CA MUT" "WH.4.023_IC_50" 0.0930107070968953 0.521674050404563 1.68791822723566 0.0337615675852996 0.510501526529407 1.85857461427359 0.188569594168451 0.851001889249827 1.35348447667144 "MS-HL MUT" "Cytarabine_IC_50" 0.0526785987605056 0.410025096925548 -0.515096457081541 0.0338106950504736 0.510501526529407 -0.431189611813478 0.100608543102097 0.774133667469059 -0.441919137133569 "CDK4 MUT" "CHIR.99021_IC_50" 0.171703340651934 0.649721929411943 0.697569695121953 0.0338499563770414 0.510501526529407 1.03021451446454 0.0824924829059188 0.745860856369627 0.907240301327322 "SMARCB1 MUT" "OSI.906_IC_50" 0.0341195288667347 0.341233711560215 -3.05295124521742 0.033857155627274 0.510501526529407 -2.87464004323035 0.0573125154044805 0.700127165484445 -2.78639482654771 "MYC MUT" "AZD7762_IC_50" 0.033163367989017 0.335831095907024 0.624868029825455 0.0340032667293696 0.511484150226521 0.488097335298237 0.0210006025003392 0.543750293893623 0.644538006868726 "MS-HL MUT" "FTI.277_IC_50" 0.10561979351815 0.549185823322416 0.22697146763393 0.0340914634546005 0.511484150226521 0.27216988825139 0.889120910434889 0.988301482344111 0.0206709347533659 "PTEN MUT" "AZD8055_IC_50" 0.909813471141138 0.981755900994977 -0.0207016820529585 0.0340951038097174 0.511484150226521 0.304557597556244 0.575815039575249 0.949294892873838 0.107692047882906 "CDK6 MUT" "BI.2536_IC_50" 0.798844317523028 0.949864290255993 -0.335393326530612 0.0342120308304933 0.512053251754425 -1.64557431556531 0.953665759938382 0.99568364368633 0.096975940343361 "CCND1 MUT" "BI.D1870_IC_50" 0.160484632676314 0.636336191287136 -0.462396271314738 0.0342483539626313 0.512053251754425 -0.604593724218122 0.0477609585224607 0.675422090187856 -0.66761404716725 "FGFR2 MUT" "AZD8055_IC_50" 0.208480713386308 0.681958458778563 -1.26404695445545 0.034432311914716 0.513938423722004 -1.66381759594244 0.338758774919639 0.90661482665324 -1.31218331984426 "SETD2 MUT" "Obatoclax.Mesylate_IC_50" 0.010643266964121 0.183539522152152 4.15524442956526 0.0345798022474296 0.514173263355312 2.54240660939496 0.0196934313127698 0.526799287616593 3.64331712578477 "CDKN2a(p14) MUT" "Mitomycin.C_IC_50" 0.0103746614452308 0.181016440658339 -0.491578937433083 0.0346340253339244 0.514173263355312 -0.332344495725235 0.126287733041432 0.817150972850516 -0.318676811164646 "MYCN MUT" "BI.D1870_IC_50" 0.0300024775014622 0.32084814026273 -0.775998803500853 0.034669087540881 0.514173263355312 -0.675981416947407 0.760953144507996 0.969901216545994 -0.125559716540213 "MSH2 MUT" "EHT.1864_IC_50" 0.0226742476537896 0.275471947213824 -1.44347948430495 0.0347369933515958 0.514173263355312 -1.3328287320826 0.024367518543001 0.569786836641336 -1.38719545761081 "VHL MUT" "Doxorubicin_IC_50" 0.221887930136515 0.694197984755969 0.847519137961333 0.0348397105028742 0.514173263355312 0.917247022189968 0.242082942353391 0.875707386589409 0.837413174253221 "CDKN2A MUT" "RDEA119_IC_50" 5.12288995926102e-05 0.00620421400982985 -0.838271048501022 0.0349169266266599 0.514173263355312 -0.411793936981025 0.251627776277523 0.875707386589409 -0.233600954563812 "MSH2 MUT" "BIBW2992_IC_50" 0.0113206830462511 0.189338956937394 -1.82209422687466 0.0349342939087212 0.514173263355312 -1.45054810607756 0.0224184292367929 0.556343546214722 -1.52834624604782 "ALK MUT" "OSI.906_IC_50" 0.0389421506266964 0.358017846496574 -2.97563324521741 0.0351406825951508 0.514173263355312 -2.86712376711318 0.0641423780865192 0.706338462496173 -3.77567945295226 "PTEN MUT" "Bryostatin.1_IC_50" 0.0765557227804257 0.483908451254776 -0.261896733094213 0.0351771300560816 0.514173263355312 -0.30024342139232 0.105008878941984 0.788057589876989 -0.248017481672518 "TP53 MUT" "Cytarabine_IC_50" 0.00191374461301903 0.0656214899931353 0.564750073510531 0.0351852277316963 0.514173263355312 0.300557402774995 0.00755089843970767 0.387627335508924 0.483975727134622 "KDM6A MUT" "NU.7441_IC_50" 0.00332300574293587 0.09368766350163 -1.06259848706897 0.0352213589112694 0.514173263355312 -0.673951895082802 0.00599931193514051 0.367447512386089 -0.990279195563171 "CDKN2A MUT" "Paclitaxel_IC_50" 0.0084019986487864 0.161162311014842 -0.823119322751319 0.0352447228471479 0.514173263355312 -0.303856555578261 0.382307142735045 0.915134825237766 -0.317180261482052 "TP53 MUT" "CEP.701_IC_50" 0.00218370487778991 0.0704826253139796 0.519031423327556 0.0352589875100313 0.514173263355312 0.27741824349366 0.0511475448224916 0.689395114310948 0.322718752445919 "MLLT3 MUT" "GSK269962A_IC_50" 0.0282780838003086 0.311199085787534 -1.62458786062719 0.0353808737665369 0.514173263355312 -1.4450225721748 0.0682903249960185 0.72029260842 -1.42113908491354 "PTEN MUT" "Cisplatin_IC_50" 0.0017122135353724 0.0608246736305692 -0.645164643318644 0.0354785567784298 0.514173263355312 -0.383610715925712 0.00590133278823159 0.363956503418644 -0.589913463802099 "FGFR3 MUT" "Rapamycin_IC_50" 0.0171589259358433 0.240174702440681 -5.0767939630872 0.035490203019945 0.514173263355312 -3.82899499077109 0.0312338496348719 0.613689864175437 -4.66167905421377 "RB1 MUT" "BMS.536924_IC_50" 0.0298787448331893 0.32047479814439 0.881679069859 0.0355453294081307 0.514173263355312 0.648824828605971 0.974285459244508 0.99742775226181 -0.0146103364022878 "MSH6 MUT" "JNK.Inhibitor.VIII_IC_50" 0.18652514316821 0.662380873013605 0.57377021428571 0.035601096302911 0.514173263355312 0.870396733531391 0.170819771973927 0.842832361237713 0.5960250677438 "TP53 MUT" "CCT007093_IC_50" 0.407324402939977 0.809352267869285 0.0836730093689782 0.0356266457106619 0.514173263355312 0.226878502306304 0.139061041007538 0.831473272394224 0.163255998631905 "BRCA2 MUT" "CMK_IC_50" 0.393997136401687 0.803095838508923 -1.03231121088436 0.0356970119623356 0.514173263355312 -2.34027910174919 0.351996974348182 0.91110953125066 -1.16966977060126 "FLT3 MUT" "Vorinostat_IC_50" 0.225065834150915 0.696809397503067 -0.88858202761343 0.0357057494422935 0.514173263355312 -1.1857586532314 0.711696032715862 0.962630898212352 -0.24793423771268 "CCND3 MUT" "NVP.BEZ235_IC_50" 0.457657705236072 0.828966839128293 -0.811819994035787 0.0357217546999468 0.514173263355312 -1.65353526470427 0.583248921662074 0.949294892873838 -0.566436179512685 "EZH2 MUT" "SB590885_IC_50" 0.0745253840384333 0.480000945545953 -1.62689803861791 0.0358641096420243 0.515386986619446 -1.58952275289275 0.282155908062315 0.887872038823822 -0.857468804930014 "MSH2 MUT" "Metformin_IC_50" 0.00706711111108029 0.146642555554916 -1.47094644913626 0.0361402012307739 0.516413038198387 -1.06713938607831 0.0792320722077657 0.741811190933953 -0.948109947090144 "PTEN MUT" "MG.132_IC_50" 0.0252915361380737 0.2955449111082 -0.823090980739283 0.0361626322144762 0.516413038198387 -0.692249583946186 0.249107840237707 0.875707386589409 -0.4337415848185 "CCND2 MUT" "Mitomycin.C_IC_50" 0.179781498588047 0.658614416960816 -1.71936311091752 0.0361951448197355 0.516413038198387 -2.08642788844716 0.00984612528089478 0.441633528381952 -3.91981640422854 "FLT3 MUT" "PF.02341066_IC_50" 0.00728260099370726 0.148682251551987 -2.51757393602689 0.0362881748677752 0.516413038198387 -1.8308636587526 0.0756806416315222 0.741811190933953 -1.65003030623443 "MYCL1 MUT" "PF.562271_IC_50" 0.119189542989063 0.577057450057752 0.762033424825166 0.0362955761063217 0.516413038198387 0.83360377676911 0.341925673195815 0.907180409180092 0.498697227313407 "PIK3CA MUT" "GW.441756_IC_50" 0.0822162299937053 0.497724838837149 -0.308290571198197 0.0363787427023797 0.516413038198387 -0.370645365536122 0.329903929986317 0.902810042912437 -0.188714303170427 "PIK3CA MUT" "PAC.1_IC_50" 0.117157634415473 0.572601844763368 0.386158513419731 0.0364051826909719 0.516413038198387 0.435237917220127 0.732571972076593 0.96672489654949 0.0892124128798713 "PTEN MUT" "NU.7441_IC_50" 0.0182499301623637 0.247069557579196 -0.428374167683701 0.0364420741502705 0.516413038198387 -0.340559799079849 0.0916126722773376 0.765392420032959 -0.322905407544057 "FLT3 MUT" "CGP.082996_IC_50" 0.517591589932031 0.852353345422823 0.613987906712166 0.0364588419041086 0.516413038198387 1.68275560056497 0.151942263089967 0.832065593775825 1.35104363667634 "FLT3 MUT" "ZM.447439_IC_50" 0.104205612710957 0.546977702834026 -1.50173382452709 0.0366351361025827 0.517034212848115 -1.55215114098726 0.273889798735367 0.882167181782537 -0.960161773788262 "CCND1 MUT" "Temsirolimus_IC_50" 0.0592745790218566 0.439862785571841 0.879915870396831 0.0366408089655825 0.517034212848115 0.749857358639729 0.162097990890052 0.839927262232576 0.668130214612655 "PTEN MUT" "JW.7.52.1_IC_50" 0.233726694941302 0.707628390886945 -0.50438080245984 0.036677350984609 0.517034212848115 -0.539110314625543 0.280435985891489 0.887264692092026 -0.501410393279974 "PIK3CA MUT" "AMG.706_IC_50" 0.00109265300160846 0.04784084239107 0.62569827474216 0.03679905608189 0.517927760797568 0.374710191734369 0.00203090477171417 0.257663789679908 0.601434082569051 "BRAF MUT" "Erlotinib_IC_50" 0.13422028265728 0.60172151957562 0.610972505099958 0.036899252839269 0.518516241242956 0.835046930482535 0.455825576066083 0.925809648901546 0.387736817958817 "RUNX1 MUT" "Bexarotene_IC_50" 0.189152519920799 0.664176494768233 -0.946624826923084 0.0371786266037567 0.52161671859078 -1.33295444300674 0.0664441665893863 0.713091135801027 -1.40285298904265 "CCND1 MUT" "AZD6244_IC_50" 0.0436778561733826 0.374825086237107 0.926037435497839 0.0372925446867972 0.522193795971315 0.876146085083278 0.0338145537296164 0.618827479917328 0.941770451958554 "CDH1 MUT" "X17.AAG_IC_50" 0.181193068962877 0.658636992153339 -1.04467980298651 0.0373373562033313 0.522193795971315 -1.44800729305742 0.454143610664653 0.925809648901546 -0.552266102717824 "EZH2 MUT" "Bicalutamide_IC_50" 0.0142680778445944 0.217349570047758 0.576553523809532 0.0374208437184906 0.522538542553326 0.464489748921093 0.0977852390831788 0.772625185318248 0.393577159109735 "VHL MUT" "DMOG_IC_50" 0.185977868526733 0.661726542622564 0.842142247386745 0.0376306047759141 0.523563747938021 1.19558866671267 0.0792585816592143 0.741811190933953 1.14173007122485 "RB1 MUT" "AZD.2281_IC_50" 0.00797150558915949 0.156679237330372 -0.565224230769227 0.0376698920205139 0.523563747938021 -0.343254952674921 0.0159305095944956 0.507092672791094 -0.50141333719874 "JAK2 MUT" "JNK.9L_IC_50" 0.437736634974336 0.823808548892323 -0.405201635031065 0.0377492359555725 0.523563747938021 -0.84691754660326 0.460577848631534 0.928368559622481 -0.415648540843926 "GNAS MUT" "BMS.509744_IC_50" 0.049399017267197 0.396208990300351 -1.96891574829933 0.0377877986752939 0.523563747938021 -1.54097737391831 0.0264402058664348 0.585472903331568 -2.19412606592338 "BCR_ABL MUT" "X17.AAG_IC_50" 0.147259741099293 0.619919550890177 1.59498813575527 0.0378436452605095 0.523563747938021 2.42747069432138 0.544362054540718 0.946853280734584 0.605016323875085 "CDKN2A MUT" "GSK269962A_IC_50" 0.000645897620129612 0.0346229488231849 -0.945896339029932 0.0378479817786521 0.523563747938021 -0.574315142295541 0.0436262443822825 0.659657620288543 -0.649330520284618 "MS-HL MUT" "Doxorubicin_IC_50" 0.272281939395475 0.734000646544246 -0.274523078483399 0.0380341045399047 0.524722468659587 0.32677596252238 0.31640852384115 0.900648750074761 -0.265650386044506 "SETD2 MUT" "JNK.9L_IC_50" 0.232194458616413 0.704757001699372 -1.16162276379313 0.0380499121514215 0.524722468659587 -1.59200032068092 0.231205884036732 0.869273594856142 -1.15549387795867 "HRAS MUT" "PD.0325901_IC_50" 0.0160114206399523 0.230092923468311 -2.42515500597611 0.0382148509660225 0.52588686694024 -1.96887498205051 0.0494136398702856 0.679896345274018 -1.72903995269704 "PIK3R1 MUT" "CGP.082996_IC_50" 0.67032146089941 0.906882709825482 -0.31403288659794 0.0382621282668114 0.52588686694024 -1.27746200386939 0.752972825927746 0.968780465757047 -0.227520182285553 "CTNNB1 MUT" "S.Trityl.L.cysteine_IC_50" 0.177601992925134 0.656513564381252 -1.15857857126438 0.0383668404502338 0.52588686694024 -0.961177217509417 0.378992060312894 0.915134825237766 -0.856082644755697 "NRAS MUT" "Vinorelbine_IC_50" 0.571595955490677 0.872389778906173 0.183468678571429 0.0384007770641683 0.52588686694024 0.509935058788073 0.208300131970345 0.853446327418758 0.458221547469239 "CCND1 MUT" "Parthenolide_IC_50" 0.0081630101758455 0.158981783709833 1.41911801532567 0.0384915619370732 0.52588686694024 1.0461277475637 0.0675923386270407 0.719539038493615 1.20334180660341 "BRCA2 MUT" "Methotrexate_IC_50" 0.160575257094837 0.636336191287136 1.55903035211268 0.0385165641200581 0.52588686694024 1.74815537519219 0.169157953148106 0.84067330207935 1.21517202640361 "PTEN MUT" "GSK269962A_IC_50" 0.0263466520185308 0.300365361459014 -0.799387199637919 0.0385488515232628 0.52588686694024 -0.709005917238011 0.447846205313577 0.925809648901546 -0.299210857527595 "CDKN2C MUT" "Mitomycin.C_IC_50" 0.0327258300958259 0.333904808801746 1.50657045855379 0.0386909992773378 0.527016510095148 1.1377079319979 0.136654444988638 0.830541253822459 1.21936551758672 "CDK6 MUT" "GW843682X_IC_50" 0.944441680099568 0.990147156460271 0.0986206972789113 0.0388131383326448 0.527845297827068 -1.49881797000977 0.703673952214292 0.962139809888331 0.682528510066528 "KRAS MUT" "NSC.87877_IC_50" 0.317961258005813 0.761258739353268 0.133139765853658 0.0388806020497247 0.527845297827068 0.286614313463024 0.0568087910734717 0.697813103075383 0.294775923591663 "KDM5C MUT" "Gemcitabine_IC_50" 0.470297068490848 0.832012966658205 1.46782222600351 0.0389737703195501 0.527845297827068 2.80528999384105 0.331654257450257 0.902810042912437 1.84160481548408 "RB1 MUT" "AICAR_IC_50" 0.810938039294098 0.952889749533063 0.0585048315047023 0.0389925523253754 0.527845297827068 0.466010755186337 0.735955290868247 0.96672489654949 -0.0869221062106681 "CDKN2C MUT" "SL.0101.1_IC_50" 0.210122003247983 0.684261946425694 -0.543000898058258 0.0390490215822975 0.527845297827068 -0.782202899109491 0.330611533074628 0.902810042912437 -0.433822574110614 "CDKN2a(p14) MUT" "Z.LLNle.CHO_IC_50" 0.000767894390672653 0.0376777352683085 -0.751096362500001 0.039144843920937 0.528065486845851 -0.45932936127413 0.323806874822529 0.900918773778407 -0.246174578271691 "NF1 MUT" "A.443654_IC_50" 0.0105736901997435 0.183050570494975 1.51951678638498 0.0391842310360788 0.528065486845851 0.801987228109216 0.0160683704653143 0.507840562642194 1.68655338925778 "PIK3R1 MUT" "Pazopanib_IC_50" 0.159963827741364 0.636336191287136 -0.94186111950791 0.0393338376675427 0.529278503523404 -1.17269013185106 0.0998659799711107 0.774133667469059 -1.00270835284448 "CDKN2C MUT" "CEP.701_IC_50" 0.177101328564791 0.656442779208643 0.887154981765833 0.0394453674152997 0.529976260234912 0.995000136761846 0.0169355521718606 0.513211661128791 1.52135446945257 "CCND1 MUT" "X681640_IC_50" 0.374231134757705 0.794193236181393 -0.309334811532794 0.0396431716197884 0.531829315944624 -0.614924495537508 0.22331047163744 0.866413411363959 -0.432165745508426 "BRAF MUT" "Embelin_IC_50" 0.000651056463627056 0.0346229488231849 -0.688484508881918 0.039854733693239 0.532195270402514 -0.365355918222764 0.00862284254032987 0.409515853479517 -0.628864079317592 "RUNX1 MUT" "PAC.1_IC_50" 0.334242535827712 0.773264085106582 -0.74833970279721 0.0398554450311576 0.532195270402514 -1.32806273129696 0.0800352514412056 0.741811190933953 -1.45156663704394 "CDH1 MUT" "Rapamycin_IC_50" 0.102336141883364 0.542595388696212 -2.21764339322033 0.0398827379657932 0.532195270402514 -2.44689088727115 0.177426542244901 0.848722027112292 -1.89999399117016 "FBXW7 MUT" "Nilotinib_IC_50" 0.810866405278282 0.952889749533063 0.0835927332015805 0.0399101508938267 0.532195270402514 0.582705683170683 0.0777712413331023 0.741811190933953 0.586072960587544 "MYCL1 MUT" "DMOG_IC_50" 0.126254312498161 0.587206821914858 -0.872123531468523 0.0399885706708875 0.532249498464297 -1.05321549226659 0.00229826050518273 0.262338505131915 -1.7854044143299 "PIK3CA MUT" "JNJ.26854165_IC_50" 0.0194642855042126 0.252787916799651 0.409124894147613 0.0400340800556413 0.532249498464297 0.340978871231604 0.360730315078723 0.91161229252998 0.166395168648713 "MLLT3 MUT" "CHIR.99021_IC_50" 0.0189858637957435 0.251111880766628 -0.729803464285709 0.0402017280932099 0.533015290102047 -0.602470387773375 0.018961849984405 0.516564999115032 -0.7340419632721 "BCR_ABL MUT" "ABT.888_IC_50" 0.00208795076241306 0.0684246890073447 -1.62568417590824 0.0402117153888494 0.533015290102047 1.11414376460546 0.266702716748761 0.877052916121269 -0.567527552458285 "NRAS MUT" "GNF.2_IC_50" 0.0931623740504039 0.521674050404563 0.475425241038962 0.0403126738232778 0.533557162778733 0.574081904761887 0.147985808156397 0.831473272394224 0.46813869529173 "EWS_FLI1 MUT" "Camptothecin_IC_50" 4.01531069160379e-07 0.000104882277212157 -3.0476498360611 0.0405611566350821 0.535210517278034 -0.839052634154212 0.0654800676362794 0.711992560878964 -1.14022299227565 "SMAD4 MUT" "Z.LLNle.CHO_IC_50" 0.17890768609317 0.658614416960816 0.932016248640631 0.0406575967021908 0.535210517278034 1.350837117637 0.0574909489846927 0.700319715214265 1.35356148780995 "CDKN2A MUT" "Imatinib_IC_50" 0.00190607732575707 0.0656214899931353 -0.51671691929517 0.0406899335802065 0.535210517278034 -0.352666571037963 0.0405231246902033 0.653150399952261 -0.417004756738974 "IDH1 MUT" "Nutlin.3a_IC_50" 0.0620106503392222 0.448539201336004 -2.46291670703122 0.0407063750897245 0.535210517278034 -2.45822883426878 0.0973565955019684 0.772625185318248 -2.13107543993604 "CDKN2A MUT" "Bosutinib_IC_50" 0.000132099846285674 0.0117804301702479 -0.596561566244962 0.0407470311736272 0.535210517278034 -0.272259013463816 0.00616855800619991 0.368388397903175 -0.450802207346763 "KIT MUT" "PD.0325901_IC_50" 0.199530402904164 0.674012093366938 1.44567543339961 0.0408006642897592 0.535210517278034 2.16493674211453 0.122403015869821 0.810576117427226 1.53613618215187 "FLT3 MUT" "PHA.665752_IC_50" 0.0423903822938896 0.370724581135392 -1.60837936026934 0.0408594449627865 0.535210517278034 -1.62199777841215 0.029474431735422 0.59799127175549 -1.77515144693248 "RB1 MUT" "BAY.61.3606_IC_50" 0.250623543198902 0.717470497840808 -0.28708925843563 0.0409301077765223 0.535346520122672 -0.363901062045008 0.171941724984946 0.842832361237713 -0.363694920633018 "TSC1 MUT" "Pazopanib_IC_50" 0.0472195073885202 0.384922051833884 2.6439019182609 0.0413052238132588 0.537717426910152 2.31278225669019 0.0350276678641413 0.622161436602877 2.55694445750668 "MSH2 MUT" "JNJ.26854165_IC_50" 0.0376320118404981 0.352542085607029 1.18654576576577 0.0413764691196386 0.537717426910152 1.09082870974202 0.191386734767491 0.851001889249827 0.707027337984273 "EWS_FLI1 MUT" "Bexarotene_IC_50" 0.133185435633506 0.599882846645128 -0.630410322064064 0.0413846808010734 0.537717426910152 -0.818491976239292 0.0333954561849148 0.618827479917328 -0.973192635299777 "MYC MUT" "CHIR.99021_IC_50" 0.00398918669794148 0.103752852411227 0.645393026360261 0.0414018492872284 0.537717426910152 0.439439959607206 0.0668842473876015 0.715661447047336 0.41974858698036 "SMARCB1 MUT" "DMOG_IC_50" 0.110049832621193 0.558806497146265 2.02374586206897 0.0414141110242703 0.537717426910152 2.31387567918986 0.351978415106433 0.91110953125066 1.12635701504735 "ERBB2 MUT" "Bryostatin.1_IC_50" 0.0464849835025653 0.384030826498868 0.616857178361343 0.0415102733566883 0.537876248974556 0.612361811752108 0.0248395183858614 0.571841777133554 0.70387177124143 "CDH1 MUT" "Metformin_IC_50" 0.013435834986718 0.209707645899898 -1.26461865384616 0.0415474728968073 0.537876248974556 -0.985592991104726 0.00443412482255998 0.347668977848085 -1.53246584312716 "SETD2 MUT" "AZD6482_IC_50" 0.0408091057250528 0.364613348032389 -2.84382318448283 0.0417926533945438 0.540262816298317 -2.40006159199001 0.139425198065478 0.831473272394224 -2.00995855585083 "KIT MUT" "BAY.61.3606_IC_50" 0.386927596963512 0.799351737348069 0.742649692307698 0.0419983705957657 0.54192080501181 1.21438337593419 0.518630879207843 0.939635632721979 0.521370199327188 "CDH1 MUT" "Parthenolide_IC_50" 0.111724783721021 0.563072279454009 -1.14123635374151 0.0420933377580955 0.54192080501181 -1.38588036601063 0.0636666802816597 0.70501719149803 -1.40056813896765 "APC MUT" "PLX4720_IC_50" 0.00826213222273226 0.159584363220549 0.92134607404989 0.0422285973918698 0.54192080501181 0.66213368034124 0.0246921766903383 0.571841777133554 0.873401562090487 "TP53 MUT" "BI.D1870_IC_50" 0.150112699218819 0.624794485146659 -0.213107452303531 0.0422830973614821 0.54192080501181 -0.271266696118822 0.0182539512469657 0.513871228544795 -0.356185979906512 "SMARCA4 MUT" "GDC0941_IC_50" 0.114508482894912 0.567167686753817 0.914714524008348 0.0424290422223459 0.54192080501181 0.939902030326137 0.0224266399667684 0.556343546214722 1.49901264152631 "MYCN MUT" "CCT007093_IC_50" 0.081484278278157 0.495658818759118 -0.435114237196032 0.0424317858540524 0.54192080501181 -0.539170188187639 0.0933853071628169 0.768046723169691 -0.544234681356589 "CDH1 MUT" "Salubrinal_IC_50" 0.0657967691090026 0.457742485196035 -1.42323793103449 0.0424339398582132 0.54192080501181 -1.32593869707535 0.131253717452607 0.824721122422311 -1.19143084511645 "MAP2K4 MUT" "AG.014699_IC_50" 0.314543444025455 0.760194346847454 -0.462276139269401 0.0424820193172179 0.54192080501181 -0.819860459633625 0.0166574668950105 0.513211661128791 -1.07973361707916 "APC MUT" "LFM.A13_IC_50" 0.149986384692238 0.62477911934886 0.293699539170503 0.0425295749896003 0.54192080501181 0.407824171948727 0.25990013855034 0.877052916121269 0.278681831308667 "MYCN MUT" "VX.680_IC_50" 0.824501457047569 0.957177484110155 -0.1319943991342 0.042531111484431 0.54192080501181 -0.80531192328828 0.136267113271112 0.830541253822459 -1.10125263651062 "ALK MUT" "KU.55933_IC_50" 0.141978884377305 0.614480736917568 1.06616469038209 0.0427391210317966 0.542310785528594 1.31166254986983 0.144830326110305 0.831473272394224 1.28591242587442 "TP53 MUT" "QS11_IC_50" 0.159875455772351 0.636336191287136 -0.242386446570007 0.0427827363790748 0.542310785528594 -0.266833069565873 0.0836905683502874 0.746990891978797 -0.314093005721814 "FLT3 MUT" "Camptothecin_IC_50" 0.244464920010231 0.713407040228131 -1.51333546324459 0.042797564735456 0.542310785528594 -1.68093496136289 0.730067754274265 0.966278945709352 -0.397889574463993 "BCR_ABL MUT" "BI.2536_IC_50" 0.541343633060024 0.861616652986104 -0.697148047781564 0.0428059746262295 0.542310785528594 1.74017743553795 0.553069094979387 0.947568031460906 -0.71395019399493 "CDKN2C MUT" "Z.LLNle.CHO_IC_50" 0.0454138557224122 0.380132377635007 -1.49313570229886 0.0430685458801418 0.544860051227264 -1.39261725584101 0.0107941090043544 0.450367315182713 -2.24338295007907 "STK11 MUT" "Vorinostat_IC_50" 0.00751901221834803 0.152110131004895 0.769139578571437 0.0432950058006974 0.546476256079555 0.44502378986465 0.0655748300596919 0.711992560878964 0.520258162658138 "FBXW7 MUT" "FH535_IC_50" 0.0569226893709809 0.429686097336203 -0.656976293366087 0.0433502767865127 0.546476256079555 -0.599103294939732 0.0274577897493893 0.588860092297546 -0.75714256892475 "CCND1 MUT" "Erlotinib_IC_50" 0.156944145162023 0.632778052170647 -0.782562936329589 0.043504968039145 0.546476256079555 -1.02213554803965 0.508046785652893 0.937648275848574 -0.42421387517594 "MYCN MUT" "SB590885_IC_50" 0.578826742425174 0.874194311383525 0.225255938345864 0.0435745887438281 0.546476256079555 0.707651756168559 0.197321076149795 0.851001889249827 0.555590499176772 "EWS_FLI1 MUT" "Cisplatin_IC_50" 0.000123522293348966 0.0111938927268588 -1.71233225963943 0.0436412693512209 0.546476256079555 -0.831670105260904 0.00288999157657312 0.278978425995064 -1.47287123199322 "PIK3CA MUT" "GSK.650394_IC_50" 0.0477421056912641 0.387212457209239 -0.58788951873097 0.0436794306096712 0.546476256079555 -0.390026386403671 0.0279945175678064 0.593383856475215 -0.712510204668486 "MET MUT" "PD.0325901_IC_50" 0.0367799836859609 0.350099716093267 1.49521921327967 0.0437021083465513 0.546476256079555 1.35918866139007 0.000914754379320621 0.15929281652444 2.06073467556131 "PIK3R1 MUT" "CCT018159_IC_50" 0.194805425565722 0.670441006096806 -0.698095974925777 0.0437306907523358 0.546476256079555 -1.00866726481549 0.0721458429619155 0.735136682279868 -0.976789149930884 "APC MUT" "KU.55933_IC_50" 5.25860386713795e-05 0.00620421400982985 0.933170279389929 0.043750097744912 0.546476256079555 0.437811605673167 0.00346968511918163 0.307545333416453 0.821158856435438 "PIK3R1 MUT" "AG.014699_IC_50" 0.0193427704782505 0.252622271496092 1.27733662358278 0.0440081903176485 0.548141266417824 0.967341638065448 0.0830808554914736 0.745860856369627 0.878778871251058 "EWS_FLI1 MUT" "SB.216763_IC_50" 0.294549224648518 0.747036827777118 0.413122731679492 0.0440701672125893 0.548141266417824 0.818181886720046 0.126859200774577 0.817150972850516 0.672788841271532 "JAK2 MUT" "SL.0101.1_IC_50" 0.147284118047323 0.619919550890177 -0.723457156673104 0.0441452683060822 0.548141266417824 -0.874924858729954 0.123628271158313 0.814000156875798 -0.815057915932871 "CDKN2a(p14) MUT" "BIRB.0796_IC_50" 0.509956863898095 0.849206188535564 0.0717707875095206 0.0441908290620131 0.548141266417824 0.217520874514715 0.213504859053219 0.859146648505501 0.14995925313654 "NOTCH1 MUT" "PF.4708671_IC_50" 0.034700454919811 0.34394502248085 1.24316340090091 0.0441919994094316 0.548141266417824 1.16787124285964 0.0278229368248701 0.592555160531585 1.30224080473986 "FBXW7 MUT" "JNJ.26854165_IC_50" 0.0190330629735182 0.251111880766628 0.723120552995385 0.0443139371623007 0.54888713519999 0.579056379761727 0.10816641962011 0.792785095696032 0.491479542168216 "FLCN MUT" "VX.702_IC_50" 0.411860947145803 0.812480994891775 -0.617031532567051 0.0444718513860319 0.549758491527206 -1.23305273810358 0.108176231325797 0.792785095696032 -1.58192170405743 "PIK3CA MUT" "Bexarotene_IC_50" 0.0263131746165746 0.300365361459014 -0.508943916401107 0.0445157264916922 0.549758491527206 -0.414731430352067 0.0333425843482174 0.618827479917328 -0.511035095529853 "FGFR3 MUT" "ZM.447439_IC_50" 0.128243581442119 0.588664235316545 1.7204086894531 0.0445894746895185 0.549758491527206 1.80426180417847 0.219446723844714 0.862485161824651 1.3084222637569 "TP53 MUT" "Parthenolide_IC_50" 0.0361709735786203 0.348410429882567 0.404086320512824 0.0446318964521017 0.549758491527206 0.376482805994618 0.0998496033182252 0.774133667469059 0.356771874621448 "MSH2 MUT" "JNK.Inhibitor.VIII_IC_50" 0.188189442735713 0.663245512002727 0.571612989010985 0.0448222371796905 0.551338349574559 0.830710417841682 0.14582043678417 0.831473272394224 0.640914948502109 "FBXW7 MUT" "Cytarabine_IC_50" 0.492633569069463 0.842990705166559 -0.290162460474306 0.0449974008837885 0.552727409749551 -0.648085893192163 0.938737922680017 0.994831655017307 -0.0318819670197364 "BRCA1 MUT" "AS601245_IC_50" 0.113885497748117 0.565669522092299 1.42735902792324 0.0451265727355484 0.553548470254704 1.45263865337759 0.124325402900767 0.817150972850516 1.38174390874719 "ERBB2 MUT" "BMS.754807_IC_50" 0.0151862039328403 0.224034347387965 1.37253396439075 0.0456745357708379 0.558272818896274 0.962354007633236 0.034456245503139 0.618827479917328 1.24386352556416 "EWS_FLI1 MUT" "LFM.A13_IC_50" 0.0105531290282136 0.183050570494975 -0.737811316725986 0.0456799581971565 0.558272818896274 -0.59607131381606 0.00466227772920176 0.349220649476767 -0.927405383893379 "SMAD4 MUT" "Cytarabine_IC_50" 0.0452777289212176 0.38006499344648 0.783234488564261 0.0457422608987657 0.558272818896274 0.605445380645501 0.236039901706758 0.87163009025269 0.456319917868684 "FGFR2 MUT" "JW.7.52.1_IC_50" 0.00507316905915668 0.122431560908615 4.3456655442177 0.0457665506790276 0.558272818896274 1.93347997239576 0.102560973332067 0.77902126462978 3.14802238571477 "FGFR3 MUT" "Gefitinib_IC_50" 0.101119969915167 0.541317934187221 -1.88346007400378 0.0458515841123091 0.558272818896274 -2.06083381704517 0.0453431213661534 0.667814694614939 -2.06389050934342 "CDKN2a(p14) MUT" "Nutlin.3a_IC_50" 0.000649650644089303 0.0346229488231849 -0.57398752265048 0.045888881634307 0.558272818896274 -0.321672698953425 0.00182874890599351 0.238839985796005 -0.567942661567867 "MYCN MUT" "Methotrexate_IC_50" 0.459549814010158 0.828966839128293 -0.393234630779846 0.0460576814597646 0.558933456302032 0.832692857232004 0.521748236641359 0.939635632721979 0.318318238789155 "SMARCA4 MUT" "Erlotinib_IC_50" 0.158272184037996 0.634384322036726 1.71874010909092 0.0461085540617389 0.558933456302032 2.18955075531881 0.277290327630601 0.884414807088842 1.81601752497606 "TET2 MUT" "AZD6244_IC_50" 0.167770729650995 0.647446641789 1.78800974655642 0.0461319922834579 0.558933456302032 2.37074034793215 0.103594511995218 0.78166768141846 2.31656615567447 "CDKN2a(p14) MUT" "JNJ.26854165_IC_50" 0.00208786399143483 0.0684246890073447 -0.336372091129987 0.0462775607734774 0.559685940814837 -0.210560581334645 0.025650665224405 0.578646945543191 -0.257302012816651 "HRAS MUT" "CEP.701_IC_50" 0.592326814291041 0.877813673424837 0.40591779859783 0.0463605728752527 0.559685940814837 1.109729615774 0.356403751021755 0.91161229252998 0.633712880572464 "NRAS MUT" "MS.275_IC_50" 0.43793159828859 0.823997992457832 0.376930920579421 0.0465530127783592 0.559685940814837 0.827673143098499 0.584975039732401 0.949294892873838 0.308172981763175 "BRAF MUT" "Sorafenib_IC_50" 0.45049797050566 0.828077050034054 0.330905967247255 0.0465593714852245 0.559685940814837 0.89979886147725 0.205042059055912 0.853446327418758 0.734176306074226 "FLCN MUT" "CEP.701_IC_50" 0.310322850635856 0.757046299071613 -0.939810165714291 0.0465889424527515 0.559685940814837 -1.3467480122282 0.539674604800402 0.944569766818715 -0.726609436792072 "KRAS MUT" "Shikonin_IC_50" 0.211061751908647 0.684851815382059 0.304608508390242 0.0466047261677388 0.559685940814837 0.431463638084583 0.59283857257542 0.949294892873838 0.145614408499146 "ERBB2 MUT" "CI.1040_IC_50" 0.00268119291316606 0.079461023129112 1.31791093874958 0.0467354499308639 0.559685940814837 0.805815687725009 0.0580324687649391 0.70215997387469 0.785066563669412 "NRAS MUT" "WO2009093972_IC_50" 0.0115559864087879 0.191114926064144 0.784445948968108 0.0468009073266702 0.559685940814837 0.575536152945184 0.0203687061169168 0.535190766344195 0.828144738146063 "MS-HL MUT" "Docetaxel_IC_50" 0.358717521916883 0.786601117838604 0.224398414424566 0.0468686722167575 0.559685940814837 0.367302355226841 0.934776651228009 0.994729228933513 -0.021053195481771 "MLLT3 MUT" "Cyclopamine_IC_50" 0.0778332718608955 0.486980385654137 -0.836547746478874 0.0468702786331754 0.559685940814837 -0.858256777748621 0.11230177700187 0.797376436030023 -0.797825775472228 "PTEN MUT" "SB.216763_IC_50" 0.0743471626897605 0.479852581284712 -0.325726452779308 0.046887325747803 0.559685940814837 -0.358617886359792 0.34753882516839 0.909999728614578 -0.179802902313119 "CTNNB1 MUT" "Temsirolimus_IC_50" 0.0735720444455821 0.477424621155859 1.14419902951698 0.0470522921088967 0.560901216401492 0.97158373754371 0.234908626209223 0.869962136993019 0.787966350716881 "PIK3CA MUT" "OSI.906_IC_50" 0.0839324212796025 0.500607006973909 0.502881978825864 0.0471641045242469 0.561269894103917 0.552382334538786 0.294051178268517 0.894167310052 0.336824263464459 "BRAF MUT" "CEP.701_IC_50" 0.00252598702976366 0.0776238436378238 -0.791004463022638 0.0472096172610772 0.561269894103917 -0.421457958711782 0.0446221417958854 0.662691038945248 -0.570356968209445 "SOCS1 MUT" "BIBW2992_IC_50" 0.0149821257426283 0.222362081732929 -3.25965431688802 0.047447572974773 0.563344780199143 -2.54447050511603 0.056063508536362 0.697813103075383 -2.36360489755293 "NOTCH1 MUT" "Tipifarnib_IC_50" 0.0214481769021476 0.267529858241534 -1.30248707486631 0.0477147291462479 0.56375758635278 -0.768032238508491 0.0707792613902368 0.728378470923167 -1.11098129458303 "TP53 MUT" "Midostaurin_IC_50" 0.0290170820222697 0.316210068663154 0.357067847308874 0.0477181647488858 0.56375758635278 0.262354715414716 0.111353541515153 0.797376436030023 0.255642391468446 "AKT2 MUT" "KU.55933_IC_50" 0.0531284146497899 0.412441827364322 0.995009807819757 0.0477622803598925 0.56375758635278 0.9053805550435 0.094645299272284 0.770131561879207 0.854453501634565 "CDKN2a(p14) MUT" "CI.1040_IC_50" 0.000848467154233071 0.040081046791191 -0.53204148655421 0.0478383264719781 0.56375758635278 -0.293222738877515 0.968724671903829 0.997173634484198 -0.00618285484398541 "PIK3CA MUT" "CHIR.99021_IC_50" 0.0652830113835299 0.457742485196035 0.377310094696972 0.0478528228952155 0.56375758635278 0.386523885770991 0.197875593629356 0.851001889249827 0.279376073935889 "RB1 MUT" "RDEA119_IC_50" 0.00294099606940234 0.0851452377513044 1.01383883956043 0.047863215866456 0.56375758635278 0.619539969742239 0.634420393140987 0.952678811939519 0.154793225799996 "GNAS MUT" "Shikonin_IC_50" 0.497484727208688 0.844923707565453 -0.442614933566434 0.0480115395384773 0.563863096491194 -1.08359381248629 0.302829473109879 0.894219632947544 -0.66067874770742 "MAP2K4 MUT" "AZD6244_IC_50" 0.132474115727959 0.598424527863686 -0.98403871438596 0.0480692603676098 0.563863096491194 -1.17496879171942 0.492148961507082 0.933639405738697 -0.445247132991509 "TET2 MUT" "PD.0325901_IC_50" 0.0168475598362699 0.238633459180084 3.10060314087294 0.0480856569954124 0.563863096491194 2.43633146432772 0.0976202959641281 0.772625185318248 2.31625742563449 "TET2 MUT" "Bexarotene_IC_50" 0.227304925846507 0.699478533070972 -1.12182789953541 0.0481490302472326 0.563863096491194 -1.65392293579552 0.00874821422715081 0.411073494980562 -2.84372610470141 "CDKN2A MUT" "EHT.1864_IC_50" 0.0249597215843653 0.292437054605208 0.266934531918263 0.0481896284468884 0.563863096491194 0.242921714994642 0.903739046914607 0.988746233284632 0.015908140487505 "MLLT3 MUT" "Camptothecin_IC_50" 0.291600695932763 0.746611418788718 -0.553421594736837 0.0485044256056105 0.566799741846614 -0.652376847816914 0.323688416161356 0.900918773778407 -0.47899421573863 "SMARCB1 MUT" "QS11_IC_50" 0.308602950509626 0.75674113273833 1.41375104869567 0.0488717715752892 0.570132122378789 2.00164365779308 0.23974900864974 0.875707386589409 1.61284959714194 "FLT3 MUT" "CMK_IC_50" 0.0257074984330709 0.298052602590212 -2.20149862116039 0.0489179909078524 0.570132122378789 -1.79994756154685 0.02848156829995 0.595164254286719 -2.22746633321317 "SMARCA4 MUT" "CHIR.99021_IC_50" 0.0819886119368858 0.497724838837149 0.79496784965035 0.0490616539721017 0.570568620575083 0.849901534561607 0.0451941801386669 0.666726767128739 1.00947891094218 "MYC MUT" "Pazopanib_IC_50" 0.996615714571514 0.998977896287767 -0.00126691777719731 0.0491413515406992 0.570568620575083 -0.503308297040377 0.382551150889225 0.915134825237766 -0.251764274464854 "MYC MUT" "Elesclomol_IC_50" 0.0214201485610792 0.267529858241534 0.812752041633341 0.0491881160662537 0.570568620575083 0.579317503428261 0.00509250829656699 0.358956332448686 0.97631907612064 "MYCN MUT" "EHT.1864_IC_50" 0.0353686397443493 0.347105523744792 -0.656406425757368 0.0492354961709101 0.570568620575083 -0.644461904569332 0.803747175416102 0.976660896667097 -0.096974302785494 "NF1 MUT" "ZM.447439_IC_50" 0.537164418944153 0.860800650422776 -0.214887101071695 0.0493215127129094 0.570568620575083 -0.547633549983771 0.162857025824513 0.839927262232576 -0.498599572102143 "NF2 MUT" "FH535_IC_50" 0.017455855961578 0.242606348661619 -0.838022230472772 0.049340918883196 0.570568620575083 -0.599849372843578 0.0861847142971289 0.750982975021974 -0.625042932519245 "MYC MUT" "Temsirolimus_IC_50" 0.0883067154577111 0.511579869523766 0.631180548780483 0.0494295531273899 0.570850274804096 0.560247949526781 0.149955367843636 0.831473272394224 0.529477225238202 "SMAD4 MUT" "IPA.3_IC_50" 0.0063892628142248 0.138397665983245 1.06918401044552 0.0498016738718199 0.573839375461086 0.664625366543323 0.237461529026695 0.873248794735437 0.463449354479882 "SMARCB1 MUT" "BMS.754807_IC_50" 0.0399049586690788 0.361141839503332 -3.34450030782611 0.0498176059543404 0.573839375461086 -2.65142400034394 0.1117878431766 0.797376436030023 -2.57209928615111 "NRAS MUT" "PD.173074_IC_50" 0.239015915468674 0.710884241553012 0.305027452907453 0.0499461957342401 0.574561430181358 0.448634353968623 0.210590664911125 0.855272470862467 0.341920182904576 "TET2 MUT" "AZD.2281_IC_50" 0.232051114819336 0.704757001699372 -1.03552701183434 0.0500096819648902 0.574561430181358 1.2988264259711 0.19864917296345 0.851001889249827 1.20386089788708 "FGFR2 MUT" "X17.AAG_IC_50" 0.598158354784939 0.879232253518807 -0.819447895238105 0.0501093108536812 0.574962260583389 -2.69955930062568 0.273842698689552 0.882167181782537 -2.10596011382361 "CDK6 MUT" "Elesclomol_IC_50" 0.0416194768263284 0.368149973799425 1.48904126303418 0.0504645681618436 0.577809542676924 1.18586393690836 0.0506567243711058 0.687603690567731 1.34759535391262 "TET2 MUT" "Methotrexate_IC_50" 3.16156490905891e-05 0.00447438868476652 -5.29302844377503 0.0504875808036587 0.577809542676924 -1.92833582355901 0.0843629313469544 0.747749574262573 -2.15707692278474 "VHL MUT" "Camptothecin_IC_50" 0.517342791301489 0.852353345422823 -0.518210891554692 0.0506027619255496 0.578205269078378 -0.99092375928833 0.474410177665764 0.929844139269115 -0.547843398246465 "RUNX1 MUT" "Embelin_IC_50" 0.352357905935201 0.784969887597353 -0.597825472027977 0.0506523701545972 0.578205269078378 -0.999414492337059 0.0993204890094351 0.774133667469059 -1.16311814709239 "FBXW7 MUT" "Pyrimethamine_IC_50" 0.00144970943971622 0.0559776936266077 -2.25547150349652 0.050743098884903 0.578497382794382 -1.20302512264825 0.0559106314194411 0.697813103075383 -1.42094377349398 "CDK4 MUT" "Methotrexate_IC_50" 0.0222823126124848 0.272504078959254 1.69877209010841 0.0508769022848766 0.578657430116152 1.10342640213959 0.0611331277690564 0.702860976445846 1.16250031425148 "PIK3CA MUT" "Mitomycin.C_IC_50" 0.0826896100733104 0.498552626562699 -0.548923729835 0.0508874510664018 0.578657430116152 -0.487125145572562 0.0233225075241611 0.565154616698372 -0.764624635469306 "MYC MUT" "BMS.536924_IC_50" 0.430479527037655 0.820918238409269 -0.414681444139193 0.0510778309611086 0.57991306324473 -0.777397082329776 0.0145611674267739 0.489839878474164 -1.28632208348592 "MAP2K4 MUT" "Docetaxel_IC_50" 0.749883913712428 0.932697982453688 -0.16828127034121 0.0511284684743411 0.57991306324473 -0.771873491640609 0.529328440032794 0.943054040048671 -0.354154557737591 "SMAD4 MUT" "X681640_IC_50" 0.364735838587779 0.787556280694886 -0.297713450713466 0.0512522404409695 0.580335883150179 -0.562668175523871 0.0558251812430216 0.697813103075383 -0.628090113562255 "VHL MUT" "CEP.701_IC_50" 0.239384014152686 0.711026565113714 -0.773470446257182 0.051339117596996 0.580335883150179 -0.938768075122217 0.139714577898981 0.831473272394224 -0.954338324708133 "MAP2K4 MUT" "BI.D1870_IC_50" 0.0115041285884234 0.190612249988411 1.18396618414238 0.0513617840508997 0.580335883150179 0.788288631972234 0.0179701681431334 0.513211661128791 1.1639872252935 "CTNNB1 MUT" "Cisplatin_IC_50" 0.180130132156776 0.658614416960816 0.623619566040543 0.051677734790672 0.582461814565951 0.784668401254978 0.570271418402019 0.949294892873838 0.276488045520091 "NOTCH1 MUT" "Sorafenib_IC_50" 0.516777817432799 0.852353345422823 0.353367898245616 0.0517751126655724 0.582461814565951 1.05815310200534 0.286616312621939 0.888460548829126 0.689338284179387 "MS-HL MUT" "JNK.Inhibitor.VIII_IC_50" 0.185244809547262 0.660550500647272 0.203058436644771 0.0518054426025762 0.582461814565951 0.284847806361422 0.0999982704829407 0.774133667469059 0.278295121638352 "RB1 MUT" "BMS.708163_IC_50" 0.0405677881481122 0.363921743983217 0.420445137583037 0.0518122771655333 0.582461814565951 0.41045838762556 0.0358074953972968 0.627231492353831 0.472824372694312 "FBXW7 MUT" "GW843682X_IC_50" 0.00294331584164513 0.0851452377513044 -2.31543283972127 0.051942404376266 0.582670810907131 -0.799929129261372 0.00447345527558534 0.347668977848085 -2.37216614524787 "BCR_ABL MUT" "ATRA_IC_50" 7.38424540997189e-06 0.00129676558252715 -3.84394461206889 0.052064912400403 0.582670810907131 -1.67980242269893 0.0180875182899799 0.513211661128791 -1.84601024959162 "FGFR2 MUT" "VX.680_IC_50" 0.393895926914919 0.803073858340542 1.29998025824801 0.0521312495022699 0.582670810907131 -1.97541775724357 0.880729474013784 0.988301482344111 -0.288357295790122 "SMAD4 MUT" "Bexarotene_IC_50" 0.279904852542486 0.737882141891724 0.330537153976847 0.0522326514972553 0.582670810907131 0.544731460664397 0.374738324567561 0.914299741891349 0.278582633303737 "GNAS MUT" "AZ628_IC_50" 0.29466169044981 0.747036827777118 1.42216510616438 0.0524986581259353 0.582670810907131 1.95117016698073 0.285248847845461 0.8879937007725 1.28863580358982 "KDM6A MUT" "VX.702_IC_50" 0.794086364909992 0.948646027682356 -0.102459458577951 0.0525151109581776 0.582670810907131 0.625451917571197 0.680497413977264 0.961100601384891 -0.155790616080295 "PTEN MUT" "Bleomycin_IC_50" 0.0879812090325882 0.511142337432447 0.660159652725969 0.0525575767911946 0.582670810907131 0.622593217341098 0.381932173961465 0.915134825237766 0.353267547361736 "KRAS MUT" "VX.680_IC_50" 0.965049779165866 0.994434372972651 0.0250133121516161 0.0525582988109815 0.582670810907131 0.769979939335666 0.631662875383514 0.952523560833852 0.309700637295738 "MS-HL MUT" "WO2009093972_IC_50" 0.095994078332277 0.529517645757113 -0.41151653068229 0.0525783029441291 0.582670810907131 -0.432406157870924 0.00583283986636789 0.363430115778537 -0.741186483982858 "SMAD4 MUT" "Lapatinib_IC_50" 0.00339551511131329 0.094828835545828 -1.98170103759398 0.0526026392769951 0.582670810907131 -1.16269691882711 0.511260110304314 0.939086342216131 -0.416266218800587 "FBXW7 MUT" "AZD6244_IC_50" 0.0559833020751252 0.42507280266688 -0.975877474197004 0.0526339844461418 0.582670810907131 -0.904273919516478 0.277813004911402 0.885251188642035 -0.529829384551444 "BRAF MUT" "Midostaurin_IC_50" 0.068719642906251 0.464105816464194 -0.481267481076418 0.0527178215179363 0.582670810907131 -0.435555559180691 0.19616152006677 0.851001889249827 -0.371927647051271 "MDM2 MUT" "Methotrexate_IC_50" 0.0189113177398682 0.250673750519059 1.65658864562118 0.0527496658573496 0.582670810907131 1.03903163279521 0.0112587698461211 0.450437967177441 1.40848136991021 "MET MUT" "Obatoclax.Mesylate_IC_50" 0.439048717025075 0.824179170555842 0.542418138772891 0.0528168317702098 0.582670810907131 0.999373179491521 0.54924014668559 0.947060194029534 0.403625615375864 "MLL_AFF1 MUT" "CMK_IC_50" 0.163074328169333 0.638639513991862 1.68746565986395 0.0528219566746454 0.582670810907131 2.16925997553029 0.126895518590285 0.817150972850516 1.89795149121936 "MS-HL MUT" "Metformin_IC_50" 0.0178697990551467 0.245008564936728 -0.456669114183308 0.0528806073179988 0.582670810907131 -0.348955230029562 0.225732637807949 0.86643108387559 -0.250909184305184 "TP53 MUT" "GSK269962A_IC_50" 0.0820175024146431 0.497724838837149 0.486744636458334 0.0529731153073486 0.582966836486447 0.529482599336852 0.339407189074712 0.907039453844874 0.290937951784527 "KDM6A MUT" "Erlotinib_IC_50" 0.0156832623701549 0.227586688087166 -1.17418010780886 0.053239850894139 0.585177123503525 -0.843612871870553 0.0240021165370564 0.569786836641336 -1.17497499836124 "ALK MUT" "Embelin_IC_50" 0.0656208688035942 0.457742485196035 1.86419667826088 0.0533714331551543 0.58523840791892 1.55971652159565 0.120048705755134 0.80757178183218 2.19426977167789 "TSC1 MUT" "CEP.701_IC_50" 0.187454011868598 0.663090109477269 1.72296519544591 0.053411864755627 0.58523840791892 1.8551480355165 0.0432067746232868 0.658180729724545 2.39004502210225 "PTEN MUT" "MK.2206_IC_50" 0.00127460563766819 0.0516884596718321 -0.762345607728767 0.0534577371894601 0.58523840791892 -0.374600079195847 0.00234768867731825 0.262338505131915 -0.762485186621283 "APC MUT" "Elesclomol_IC_50" 5.309314995463e-05 0.00620421400982985 1.61705236552662 0.0536203746074829 0.58523840791892 0.675365538743945 0.0601013511848968 0.70215997387469 0.87840950630271 "ALK MUT" "AZD.2281_IC_50" 0.0138370884268379 0.212607581866345 -2.60364605314957 0.0538268690104445 0.58523840791892 -1.54393706233656 0.0331861257202362 0.618827479917328 -1.99320009351033 "SMAD4 MUT" "MG.132_IC_50" 0.610821833809155 0.884818029552257 0.431146948275863 0.0538272645573187 0.58523840791892 1.49801276312745 0.40110127690301 0.916589616820582 0.703240947377255 "GNAS MUT" "PLX4720_IC_50" 0.013761186884775 0.212607581866345 1.65428725918764 0.0539202013442142 0.58523840791892 1.14622747954745 0.0551186375294395 0.697305726351784 1.16696380574479 "AKT2 MUT" "BIBW2992_IC_50" 0.274886551426512 0.73402283606276 -0.849777119184191 0.0539455670561738 0.58523840791892 -1.43691662690607 0.38404981871051 0.915331032347709 -0.630912938308144 "TSC1 MUT" "GSK.650394_IC_50" 0.134752015054412 0.601893367640051 2.20264404869567 0.0540157799200107 0.58523840791892 1.83463412698063 0.0938376859433678 0.768683143653123 2.44869944915391 "TP53 MUT" "BMS.708163_IC_50" 0.131889148371442 0.596996700655848 0.182349209882833 0.0540577480936744 0.58523840791892 0.248469687217537 0.212045055769741 0.855697514393537 0.165155384764796 "FLT3 MUT" "Vinblastine_IC_50" 0.368856708195108 0.789246419666677 -0.929156778200238 0.0540738684346545 0.58523840791892 -1.45708879683275 0.854588078275137 0.984631915507353 -0.178690056961151 "CCND1 MUT" "MS.275_IC_50" 0.0192608207000072 0.251922457491553 1.73002555672107 0.0541682100868319 0.58523840791892 1.20589660606393 0.23498950426066 0.869962136993019 1.08977551260121 "CDH1 MUT" "Sunitinib_IC_50" 0.0281616693020915 0.310302462868331 2.32448040206187 0.0542409406019865 0.58523840791892 1.54451442106667 0.0438206994205712 0.659657620288543 1.91362779558966 "FGFR3 MUT" "GSK269962A_IC_50" 0.372611003200945 0.792043637967351 1.46145149152543 0.0542724419661904 0.58523840791892 2.93285567758859 0.432008485627776 0.922569292988365 1.28539239208041 "TP53 MUT" "Roscovitine_IC_50" 0.308918055426001 0.75674113273833 0.208703942208461 0.0542785189745146 0.58523840791892 0.367604933919265 0.0746630472564047 0.741811190933953 0.39746304609062 "PIK3CA MUT" "Pyrimethamine_IC_50" 0.049655918603705 0.397265947733618 1.29017043066089 0.0542997914790215 0.58523840791892 1.07035577450374 0.0600362789394883 0.70215997387469 1.35931829067325 "MSH2 MUT" "AZD7762_IC_50" 0.172644319728105 0.650961807890931 -0.92666471236263 0.054596901498161 0.586720425180961 -1.02136013390375 0.383377025275326 0.915134825237766 -0.543155407676273 "VHL MUT" "BMS.536924_IC_50" 0.158361927128264 0.634384322036726 -1.56998192123288 0.0546039525338335 0.586720425180961 -1.62928293080218 0.727112719386149 0.965402608571648 -0.431539974265349 "FLCN MUT" "PAC.1_IC_50" 0.742698833388797 0.929570057037101 -0.254508402097901 0.0546354905556418 0.586720425180961 -1.24418560487978 0.37636396377209 0.914419412871569 -0.849684268762527 "EP300 MUT" "MK.2206_IC_50" 0.035559683657948 0.347105523744792 2.65309357113397 0.0547434798210882 0.587170101800826 1.94496749357809 0.0393147280162183 0.64992634601437 2.51963161972212 "EGFR MUT" "VX.680_IC_50" 0.0441567884304861 0.376006653842012 1.69646754195803 0.0548826747530113 0.587952996961995 1.04462851572944 0.0659915694090049 0.712070726599122 1.61749385804615 "GNAS MUT" "WZ.1.84_IC_50" 0.0119362441099172 0.196307007296619 -2.43130209328781 0.0550098446834631 0.588605338113055 -1.54585753078486 0.0217465401096144 0.549211893050681 -2.12140252805524 "EZH2 MUT" "GNF.2_IC_50" 0.340651602973031 0.778503205456979 -0.600957441780824 0.0551479251516878 0.588966049465146 -1.15402741959169 0.161250742950226 0.839927262232576 -1.02904420192276 "VHL MUT" "A.770041_IC_50" 0.137973480731387 0.606087209949663 -1.7077139760274 0.0552027176720272 0.588966049465146 -1.81277380602964 0.699747133911266 0.961100601384891 0.494227811677324 "MS-HL MUT" "Salubrinal_IC_50" 0.206089639714457 0.679195190041394 0.37746347532255 0.0552549390941879 0.588966049465146 0.478056678408528 0.0706999960635693 0.728378470923167 0.599908173137498 "CDH1 MUT" "SB590885_IC_50" 0.421710851676793 0.816306467685614 -0.521069108606553 0.0553288127111017 0.588966049465146 -1.05302793673913 0.0566620359535506 0.697813103075383 -1.16031133171775 "MET MUT" "WO2009093972_IC_50" 0.0605317050635694 0.443915832097077 0.923758018779332 0.0553751437116762 0.588966049465146 0.843772851422876 0.0925186178758901 0.76758746139711 0.813897851386578 "FGFR2 MUT" "KU.55933_IC_50" 0.131841150867983 0.596996700655848 -1.33854536489155 0.0556617364024799 0.589714527055918 -1.52331461670106 0.43492382172661 0.922569292988365 -0.965130267829706 "KIT MUT" "AZD6482_IC_50" 0.00975840368737188 0.175079561914242 -2.27582435181974 0.0557509707341303 0.589714527055918 -1.42684511068729 0.0430924261407422 0.658180729724545 -1.74440222314998 "SMAD4 MUT" "Paclitaxel_IC_50" 0.00166217529444829 0.0594903724931988 -3.10675733103447 0.05580328562692 0.589714527055918 -0.852787594531413 0.0320690455242684 0.618827479917328 -2.24561295375342 "FGFR3 MUT" "Bicalutamide_IC_50" 0.170198350360442 0.649721929411943 0.492108037166081 0.0558089614599387 0.589714527055918 0.652104104758017 0.0875427243550765 0.755326311453013 0.572430992565392 "NF2 MUT" "AZ628_IC_50" 0.558081999928461 0.86900908342163 0.508273045454543 0.0558845334651679 0.589714527055918 1.27289499668829 0.165953670022528 0.84067330207935 1.14003133472408 "KDR MUT" "Axitinib_IC_50" 0.0432336465913258 0.374123126127403 -2.07740015462612 0.0559714522445432 0.589714527055918 -1.65745013852783 0.077381651468338 0.741811190933953 -1.61142348649814 "MSH2 MUT" "FTI.277_IC_50" 0.210160421907989 0.684261946425694 0.49126180487805 0.0560671901594688 0.589714527055918 0.68514221367534 0.662144439383668 0.958689538788368 0.164034591940757 "APC MUT" "Salubrinal_IC_50" 0.127965649681675 0.588664235316545 0.802960179257354 0.0560696599759751 0.589714527055918 0.858228148850237 0.0294470194779052 0.59799127175549 1.38205073628174 "JAK2 MUT" "SB.216763_IC_50" 0.0470225698092465 0.384922051833884 1.09783567772779 0.05611053312755 0.589714527055918 1.02101270882636 0.091249798151474 0.764454987127048 0.982070203579091 "PIK3R1 MUT" "PHA.665752_IC_50" 0.175702270009558 0.654035305374445 -0.835588711864404 0.0562135903907278 0.589714527055918 -1.16705065806076 0.166011939965616 0.84067330207935 -0.867337555317633 "PDGFRA MUT" "PLX4720_IC_50" 0.0569463502493763 0.429686097336203 1.6142983423077 0.0562345474179298 0.589714527055918 1.43417775566174 0.0186876149945657 0.516564999115032 1.83288794507199 "FAM123B MUT" "NSC.87877_IC_50" 0.0673927222721992 0.460513103960953 -0.918323500866543 0.0562423380718796 0.589714527055918 -0.941440427215641 0.116274276600168 0.802355750183445 -0.811433483145399 "BRAF MUT" "Vorinostat_IC_50" 0.203957629652634 0.675781408528279 0.231237031676414 0.0564547236610929 0.59092928952945 0.29089617133806 0.624204500943866 0.950496524771391 -0.097665087676869 "FGFR3 MUT" "S.Trityl.L.cysteine_IC_50" 0.685235236161447 0.911150491443302 -0.600046404761906 0.0564959895879468 0.59092928952945 1.53287722583205 0.788009528850741 0.975265472692061 -0.405961375177146 "MYC MUT" "Epothilone.B_IC_50" 0.32145213011433 0.762412610935476 -0.366710646023867 0.0565578083661787 0.59092928952945 -0.404591140604189 0.137454337040808 0.831473272394224 -0.566267163096802 "NRAS MUT" "JW.7.52.1_IC_50" 0.120960536276267 0.580044291137328 -0.922437236363633 0.0568760519606436 0.593146725903235 -0.71354774522219 0.255875482912724 0.875707386589409 -0.769145236109286 "BRCA1 MUT" "CCT018159_IC_50" 0.0276750027204155 0.308798590144762 1.56016123853209 0.0569166096607217 0.593146725903235 1.26151135239353 0.0432929213024538 0.658363756998446 1.43914073712323 "BRCA1 MUT" "Parthenolide_IC_50" 0.0998819346263081 0.5374999166548 1.85705161616161 0.0569704039179664 0.593146725903235 1.98973086581213 0.145683613647725 0.831473272394224 1.70974110432037 "RUNX1 MUT" "Doxorubicin_IC_50" 0.278177808805624 0.736582325582214 0.949344494755253 0.0570500887446269 0.593280840914557 1.03567617855831 0.68384760258284 0.961100601384891 0.377158354675846 "KDM5C MUT" "X681640_IC_50" 0.078332443491605 0.486980385654137 -1.66012026016264 0.0571729824087243 0.593863458212726 -1.53074984524467 0.0975138931253665 0.772625185318248 -1.45673033509134 "MSH2 MUT" "Vorinostat_IC_50" 0.0796889033876671 0.490694424776936 -0.842991015620566 0.057290919328549 0.594393288033695 -0.697703859672221 0.343639895142362 0.907180409180092 -0.418640680395166 "FBXW7 MUT" "Rapamycin_IC_50" 0.00851963156780461 0.162018946367608 -2.67053012943875 0.0574607556594173 0.595265913457896 -1.68319257195605 0.0150118701093736 0.492634387965361 -2.5681550306022 "HRAS MUT" "X17.AAG_IC_50" 0.0448324981539567 0.378674422837037 -1.80456672104928 0.0575090816064492 0.595265913457896 -1.50804183641428 0.398492614828822 0.916480913435499 -0.667500101510913 "NF1 MUT" "Cisplatin_IC_50" 0.244221423026044 0.713407040228131 -0.420253744306973 0.0576966704490856 0.596296225844423 -0.595858736038669 0.046898188050643 0.673636396626734 -0.728638390786519 "FGFR2 MUT" "BMS.708163_IC_50" 0.0622019175194244 0.448539201336004 1.60103554241071 0.0577429066801265 0.596296225844423 1.66196072284551 0.16781276233461 0.84067330207935 1.69131222837239 "MLL_AFF1 MUT" "Elesclomol_IC_50" 0.170522670302206 0.649721929411943 2.11304557685008 0.0579955803612998 0.598209929371317 2.45829460769449 0.18964500479059 0.851001889249827 1.932707168214 "KRAS MUT" "BI.D1870_IC_50" 0.000656354958502639 0.0346969546813211 0.642802666350267 0.0581957160528472 0.599036803365063 0.328315993043617 0.325600065846282 0.900918773778407 0.205502076467486 "FGFR2 MUT" "NU.7441_IC_50" 0.0846389684117921 0.502459009669202 1.74540221696256 0.0582106475964474 0.599036803365063 1.69554377577182 0.33532861285916 0.904908359405106 1.3263601712491 "MLH1 MUT" "GDC0941_IC_50" 0.381024735754866 0.797708787892259 0.508163599164922 0.0583443041215135 0.5992755691239 0.900667608185996 0.15504542847366 0.836658903934028 0.832125906926539 "MLH1 MUT" "NSC.87877_IC_50" 0.143044805059853 0.61606176606809 0.477797368421054 0.0584043298502728 0.5992755691239 0.613733610904511 0.186496571032137 0.851001889249827 0.440281281461964 "BRAF MUT" "Nutlin.3a_IC_50" 0.000703606800577763 0.0355041590677904 -0.90434207391305 0.0584761055015002 0.5992755691239 -0.509442811508526 0.0265674563723254 0.585472903331568 -0.691545450552742 "EGFR MUT" "QS11_IC_50" 0.125493951112609 0.586857535554275 0.638751319965467 0.0585725970826607 0.5992755691239 0.582332439066223 0.149490054986632 0.831473272394224 0.616762067184623 "TET2 MUT" "Parthenolide_IC_50" 0.0613142588495745 0.447070552416314 -1.7261055855856 0.0585951294332828 0.5992755691239 -1.64182358722812 0.387905108765118 0.915926348152589 -1.00072404327821 "PIK3CA MUT" "Lenalidomide_IC_50" 0.918423559031705 0.985394748720982 -0.0158776265924854 0.0586387196902003 0.5992755691239 -0.26008157092096 0.714410911525443 0.962630898212352 -0.0598262607029453 "TP53 MUT" "Mitomycin.C_IC_50" 0.339592084057421 0.778100438213095 0.186176945979327 0.058730598023084 0.599464227712133 0.296374588844087 0.506332713417289 0.935912793170426 0.135999513851027 "CCND1 MUT" "Cyclopamine_IC_50" 0.0148569066986579 0.221903658213912 1.15276598591548 0.0587921790718689 0.599464227712133 0.838128124178816 0.0768119652996271 0.741811190933953 0.99623341873641 "MSH2 MUT" "NU.7441_IC_50" 0.0240015810921385 0.283730743483931 -1.44769895634923 0.0589005749164713 0.599880740634383 -1.06475757215425 0.00763800312466359 0.389051690900049 -1.64646132291373 "EZH2 MUT" "IPA.3_IC_50" 0.0452398647546442 0.38006499344648 -1.56911481152885 0.0590993565003714 0.600344792546199 -1.23665137111977 0.13571384677594 0.828937189282754 -1.17067247924238 "FGFR2 MUT" "Vorinostat_IC_50" 0.0364419157824485 0.349245910703174 1.87209313385823 0.0591136122637462 0.600344792546199 1.29919082311237 0.249615481760384 0.875707386589409 1.32689201247485 "PIK3R1 MUT" "FH535_IC_50" 0.021010625009325 0.263925545555608 1.30327839411248 0.0591489351962531 0.600344792546199 0.913672589680748 0.0151434734730935 0.492634387965361 1.30699929621456 "MLL_AFF1 MUT" "ABT.263_IC_50" 0.000805071135239657 0.0390701461861388 -5.1369987089843 0.0593341145076375 0.601536838975261 -2.64796335650506 0.0630716262290332 0.70501719149803 -2.51226569217781 "TET2 MUT" "Mitomycin.C_IC_50" 0.867445101257104 0.968419854715819 -0.214093418699183 0.0594754579844245 0.602282260387314 1.9068074465316 0.731042572722263 0.96639568318693 0.525283742680649 "JAK2 MUT" "BIBW2992_IC_50" 0.124517922665471 0.585102471530182 -1.10725366037219 0.0596992306707096 0.603859758071266 -1.30106956204715 0.334598248635017 0.904036217258164 -0.699921441196676 "MET MUT" "BMS.708163_IC_50" 0.0759480604701953 0.482126322398717 0.687681643181821 0.0600574745068424 0.606792299312022 0.73227762185359 0.0721809691417683 0.735136682279868 0.701479647469811 "KDM5C MUT" "AZD8055_IC_50" 0.231739553939215 0.704757001699372 0.982372277777758 0.0601617146537477 0.606980488072414 1.19773955470401 0.228345757666306 0.86812443229215 0.950744546433458 "PIK3CA MUT" "JW.7.52.1_IC_50" 0.416589249400605 0.814099702076568 -0.619481308234019 0.0602127924774008 0.606980488072414 -0.86381425414493 0.242610937041403 0.875707386589409 -0.991058717691285 "CDKN2A MUT" "Salubrinal_IC_50" 0.00651577863205676 0.140452985512855 -0.564271608265947 0.0603385443389642 0.607558517317847 -0.341886959091954 0.175933442072551 0.847235321998113 -0.324577579469337 "MLLT3 MUT" "NVP.BEZ235_IC_50" 0.150814874806642 0.625297340409797 0.562668376533742 0.0607399501876486 0.610108883040762 0.528097715564311 0.0393016881477202 0.64992634601437 0.811388368660529 "HRAS MUT" "AMG.706_IC_50" 0.115017340822388 0.567167686753817 -0.907179194499021 0.0607946727728738 0.610108883040762 -0.997740287420472 0.0491399853496482 0.679896345274018 -1.04057733684697 "MYCN MUT" "PLX4720_IC_50" 0.148214443460479 0.62208225608853 0.608119321428578 0.0607979238251407 0.610108883040762 0.723828021711531 0.254489066802666 0.875707386589409 0.527764246444281 "FLT3 MUT" "Midostaurin_IC_50" 0.0951641701089745 0.527890690029858 -1.56257203114187 0.0609035406312001 0.610478943956759 -1.36322821547662 0.0383612326870355 0.645472009508728 -1.7732542397927 "NRAS MUT" "JNJ.26854165_IC_50" 0.18920915795109 0.664176494768233 -0.296642512536291 0.0613870800915249 0.61456349458426 -0.40954571963322 0.0297212829164094 0.59799127175549 -0.538694058664574 "PTEN MUT" "PD.0325901_IC_50" 0.182260490329745 0.658636992153339 0.385457344197451 0.061449429477629 0.61456349458426 0.518236942184086 0.43914153181369 0.923517865033716 0.213154860321048 "GNAS MUT" "Vorinostat_IC_50" 0.973726925632711 0.995472410100622 -0.0158661789264417 0.0618096484084518 0.617470739612441 -0.685366106659468 0.317389981481245 0.900918773778407 -0.439296703046159 "NOTCH1 MUT" "WO2009093972_IC_50" 0.0711956585697313 0.472209592052116 1.60833073749039 0.0620776671327417 0.618406161923125 1.48357192090406 0.0578033690146693 0.70215997387469 1.65184428205815 "CDKN2A MUT" "Mitomycin.C_IC_50" 0.0107609956863491 0.184249532340571 -0.474160712771436 0.0621208488305334 0.618406161923125 -0.285360529050705 0.141462147924636 0.831473272394224 -0.304732214225129 "KDM5C MUT" "DMOG_IC_50" 0.110398883080953 0.559686423710509 -1.43207603806231 0.062130229731038 0.618406161923125 -1.50648459698624 0.179252782958673 0.848722027112292 -1.13305310968887 "NF2 MUT" "MK.2206_IC_50" 0.416201724107843 0.814099702076568 0.331355748608137 0.0623082517910395 0.618406161923125 0.611206728146847 0.469105726427022 0.929276781658587 0.308556687205851 "RB1 MUT" "BMS.509744_IC_50" 0.033353456430242 0.336222527306446 0.605487384178721 0.0623216267480696 0.618406161923125 0.411421773722022 0.910443603701467 0.990141873133243 0.0370147848317996 "CDKN2C MUT" "GSK.650394_IC_50" 0.0348381690685213 0.344540957124207 1.39827273015872 0.0623289870814622 0.618406161923125 0.802388556940356 0.138699198594288 0.831473272394224 1.1665942433717 "RB1 MUT" "Docetaxel_IC_50" 0.472559899121108 0.834010894215077 -0.18362354495074 0.0624471121572755 0.618406161923125 -0.365151266204892 0.430117799313653 0.922428741067589 -0.215894157667437 "FGFR2 MUT" "GDC0941_IC_50" 0.377750504092583 0.795731078473964 -1.13467910882959 0.0625418819739265 0.618406161923125 -1.94385255614798 0.109575034732822 0.795960407011784 -2.87973548354525 "FLT3 MUT" "PD.0325901_IC_50" 0.0260308185679825 0.299843968485412 2.88858191071421 0.0625421712678693 0.618406161923125 2.29202343431824 0.0303338176598892 0.604023844478645 2.47022879785267 "RB1 MUT" "Embelin_IC_50" 0.0216188270012745 0.269073219819667 0.429148829982805 0.0625996103556908 0.618406161923125 0.284599814899928 0.7708430983569 0.969901216545994 0.0612360467846404 "CDKN2a(p14) MUT" "CCT018159_IC_50" 0.122463641948623 0.580982694522287 0.212124338897124 0.0627188813756598 0.618895983885817 0.244932455617798 0.081224487796635 0.741811190933953 0.269000315411454 "MYC MUT" "PAC.1_IC_50" 0.0672810538227677 0.460513103960953 0.49994637322533 0.0630069834070047 0.619426147189003 0.427828805348643 0.139681720871957 0.831473272394224 0.411551655765729 "CTNNB1 MUT" "Dasatinib_IC_50" 0.757841148346061 0.934762260113025 0.497174218390808 0.0630297428867012 0.619426147189003 2.45129895016864 0.994872762988495 0.999545005862799 0.0100268741696773 "FLT3 MUT" "Epothilone.B_IC_50" 0.821734828697191 0.95646487728175 -0.263877710296688 0.0631558130841972 0.619426147189003 1.25688124035052 0.735460668272287 0.96672489654949 -0.388625591779257 "MLLT3 MUT" "GW.441756_IC_50" 0.0629664884661258 0.450893824743909 0.527602053560366 0.0631816967412684 0.619426147189003 0.515356720455003 0.0998904427129002 0.774133667469059 0.485299177165768 "FLT3 MUT" "AZD7762_IC_50" 0.220835262245504 0.693711036770013 -1.26612456552167 0.0631881068314441 0.619426147189003 -1.51714515076635 0.663670313553038 0.959206771190239 -0.411363947662241 "AKT2 MUT" "Elesclomol_IC_50" 0.417599259322706 0.814099702076568 -0.72471980433397 0.0631910921465192 0.619426147189003 -1.38032959903315 0.792773727853432 0.975393509832241 -0.223738153397361 "STK11 MUT" "Cisplatin_IC_50" 0.0360653083083611 0.347769818769332 0.755399668818358 0.0633800606573858 0.620593515654072 0.579487349550155 0.0572803580647323 0.700127165484445 0.701393010144456 "NF1 MUT" "WZ.1.84_IC_50" 0.0110828530399437 0.187804952756533 1.24741884976526 0.0635549112350502 0.62060490613657 0.767208093999346 0.0267305415406686 0.587608760947223 1.19416443705181 "RB1 MUT" "A.443654_IC_50" 0.0882419600422384 0.511538411968094 -0.568875383583048 0.0636662622004143 0.62060490613657 -0.415028775415587 0.00932902755123715 0.428092571279165 -1.03420263614475 "ALK MUT" "GW.441756_IC_50" 0.080284651624845 0.492069006956693 -1.50504578557874 0.0636729697794465 0.62060490613657 -1.57969293361279 0.0387857060999349 0.646945958867072 -1.77261538973322 "SETD2 MUT" "ZM.447439_IC_50" 0.283506854849743 0.739564104351618 -1.21371814648436 0.0636942122183073 0.62060490613657 -1.67637068651988 0.194155738755504 0.851001889249827 -1.38826832974006 "PIK3CA MUT" "NU.7441_IC_50" 0.00971475666021469 0.174676355778303 0.549152952941172 0.0637998539949628 0.62060490613657 0.348730165720351 0.113820630136364 0.799692247086917 0.358185310681093 "RUNX1 MUT" "FH535_IC_50" 0.269429453482111 0.732006752858616 -0.788226963286721 0.0638005043691802 0.62060490613657 -1.12880980715324 0.234134855959293 0.869962136993019 -0.902998774131836 "CDKN2a(p14) MUT" "AZD6244_IC_50" 0.00389499683131797 0.102686943743646 -0.603137215222485 0.0640217329911182 0.621477686160705 -0.367245334624782 0.362198225965192 0.91161229252998 -0.191401425069164 "CDKN2C MUT" "Rapamycin_IC_50" 0.137999396230186 0.606087209949663 -1.84195442517007 0.0640452103769392 0.621477686160705 -1.97263876293294 0.0767802542587318 0.741811190933953 -2.70282972910992 "CDKN2a(p14) MUT" "PD.0325901_IC_50" 0.00121667528884649 0.0507290762452849 -0.661338330781161 0.0641273018321817 0.621477686160705 -0.370627300588742 0.668531284173311 0.959230524020512 -0.0864115904762317 "EWS_FLI1 MUT" "PD.0332991_IC_50" 0.00411282270913498 0.105218450412766 -1.52723938900633 0.064170142800289 0.621477686160705 -0.850030150859186 0.297932482551243 0.894167310052 -0.606904749378955 "NF1 MUT" "AZD6244_IC_50" 0.743712691022549 0.929570057037101 -0.171409124381468 0.0643727885741497 0.621578440069374 -0.891371608208891 0.365107416446659 0.913900497593792 -0.467484084384485 "VHL MUT" "FH535_IC_50" 0.378931097385815 0.795952477739693 0.497871321616869 0.0644811821990313 0.621578440069374 0.90022142216162 0.116737801781835 0.803058417989523 0.920249371472323 "MLLT3 MUT" "BAY.61.3606_IC_50" 0.0847515897022244 0.502791495087144 -0.731574360739985 0.0644907508104745 0.621578440069374 -0.542544607422353 0.213881486757063 0.859314544932072 -0.517750634817583 "BRAF MUT" "LFM.A13_IC_50" 0.101248143681402 0.541677568695501 -0.256653315917797 0.0645078161041459 0.621578440069374 -0.300731993395607 0.175481446194862 0.846738869764556 -0.252834853032632 "MYC MUT" "JW.7.52.1_IC_50" 0.360420983713955 0.786781278801733 0.523451094322343 0.0645304945100735 0.621578440069374 0.659783624128075 0.833522291934563 0.981482581683432 -0.129715392986406 "ERBB2 MUT" "RDEA119_IC_50" 0.0357297701349328 0.347105523744792 1.20922119279711 0.0646340825360904 0.62168003433908 0.992169375533246 0.0974642024385707 0.772625185318248 0.87208105999296 "BRCA2 MUT" "CCT007093_IC_50" 0.061964361993973 0.448539201336004 -0.847725168539336 0.0646810439960939 0.62168003433908 -0.850730711912782 0.0447759846754694 0.662759199838072 -0.931693222138573 "STK11 MUT" "Bryostatin.1_IC_50" 0.0485294288535694 0.392165475567379 -0.517662983423752 0.0653039518767234 0.623925763551496 -0.456633162967413 0.184783374640596 0.851001889249827 -0.354116485884192 "EGFR MUT" "Epothilone.B_IC_50" 0.459255998004109 0.828966839128293 -0.367521660100455 0.0653448889131747 0.623925763551496 -0.523445777594261 0.693230244917154 0.961100601384891 -0.201006185941002 "SMARCA4 MUT" "X17.AAG_IC_50" 0.169607761912509 0.648981703380007 0.961619003868472 0.0654314787285692 0.623925763551496 1.12588242858702 0.18984085086767 0.851001889249827 0.918690585292122 "APC MUT" "ZM.447439_IC_50" 6.26535040487282e-06 0.00115922035303491 1.34491940013775 0.0654329892325585 0.623925763551496 0.462268616342357 0.018056744011439 0.513211661128791 0.820018176540679 "BRCA2 MUT" "Midostaurin_IC_50" 0.553918884398014 0.866925654369292 -0.453790119791672 0.0655205873365123 0.623925763551496 -1.09291450111538 0.163727488660503 0.839927262232576 -0.979346086385168 "MYCN MUT" "QS11_IC_50" 0.392423319714913 0.803073858340542 -0.381597242369835 0.0655621498005873 0.623925763551496 -0.61664998495127 0.156916054055395 0.837288218996252 -0.714713642071409 "AKT2 MUT" "MG.132_IC_50" 0.133735179391833 0.600456080980218 2.5107356081081 0.0655976976436567 0.623925763551496 2.69929869349987 0.085805575472936 0.750751691327456 2.68424392461803 "MYC MUT" "Salubrinal_IC_50" 0.120941043411022 0.580044291137328 0.556501925925924 0.0656777808169096 0.623925763551496 0.553609009584556 0.349558130106484 0.909999728614578 0.353018714774181 "CTNNB1 MUT" "CI.1040_IC_50" 0.0843935214213256 0.5016791346675 -0.865443608187141 0.0656932683772606 0.623925763551496 -0.82662124615822 0.300142827957423 0.894167310052 -0.500881359297718 "BCR_ABL MUT" "AICAR_IC_50" 0.00114583552980318 0.0489238718277981 -2.78519184466014 0.0657605430708906 0.623925763551496 -1.80649660210813 0.0317848810842826 0.617683870699155 -1.83126843496063 "SETD2 MUT" "MG.132_IC_50" 0.242825365229656 0.712432133665204 1.95701939189188 0.0657626547031977 0.623925763551496 2.75596024352275 0.0108338225182393 0.450367315182713 3.99069417876884 "MDM2 MUT" "AZD7762_IC_50" 0.0124126172276041 0.200541834057986 1.42251432301741 0.0658218650771419 0.623925763551496 0.819063575388164 0.0138615853769329 0.482141194305023 1.26725824386407 "KRAS MUT" "Docetaxel_IC_50" 0.00164359660467511 0.0594684279920107 0.678044453806075 0.0659844633238333 0.623925763551496 0.314684287896004 0.0611182247037188 0.702860976445846 0.454772065788244 "HRAS MUT" "Temsirolimus_IC_50" 0.0619152050668947 0.448539201336004 -1.74525931038877 0.0661411012619726 0.623925763551496 -1.31525929076782 0.0579121329090729 0.70215997387469 -1.68181555635285 "MDM2 MUT" "S.Trityl.L.cysteine_IC_50" 0.0880966419105406 0.511142337432447 -1.6013156886598 0.0661703572228607 0.623925763551496 -0.940043129299257 0.162546808650423 0.839927262232576 -1.33662880327884 "CDKN2a(p14) MUT" "DMOG_IC_50" 0.00140795933439058 0.0548424861786086 -0.491655099606191 0.0661885935580202 0.623925763551496 -0.267247182282394 0.316666536911918 0.900918773778407 -0.163264690034707 "BRAF MUT" "S.Trityl.L.cysteine_IC_50" 0.235004188251877 0.707962074581044 -0.560384728484851 0.0662188936719258 0.623925763551496 -0.515776314744761 0.272166267989885 0.881191624505346 -0.680089794755106 "ERBB2 MUT" "OSI.906_IC_50" 0.0334113938381424 0.336424703714901 1.06529991365546 0.066255994270558 0.623925763551496 0.88702441854797 0.0713095755094546 0.730928846615752 0.962453334443339 "ERBB2 MUT" "Parthenolide_IC_50" 0.0429215671164104 0.372980858670099 1.4507193877551 0.0663189183844676 0.623925763551496 1.25787309059736 0.0455113355820535 0.668076316205317 1.53831064190837 "CDK6 MUT" "PLX4720_IC_50" 0.275072754240122 0.73402283606276 -0.693316916020667 0.066331465087152 0.623925763551496 -1.03317597055568 0.22780033904678 0.867648638924452 -0.693450417641763 "IDH1 MUT" "PF.4708671_IC_50" 0.0848970922957651 0.5031498528273 -1.43233060538115 0.0663900288882067 0.623925763551496 -1.49654872235036 0.104764989060661 0.788057589876989 -1.37773122676636 "FLT3 MUT" "Elesclomol_IC_50" 0.0228660583056283 0.27616813704753 2.86296953548791 0.066488542664433 0.624191064907854 1.93489404060705 0.0251312217576268 0.576397395572846 2.67265229272723 "RB1 MUT" "GSK.650394_IC_50" 0.64905235413102 0.898555566178892 -0.123868014054439 0.0669210284110414 0.626429322505683 -0.330053952958978 0.104495692036496 0.787129975382627 -0.498713389691346 "BRCA2 MUT" "GDC0941_IC_50" 0.0145672359187454 0.219273935922674 2.22084815257728 0.0669588963139781 0.626429322505683 1.34868867904572 0.076780808773413 0.741811190933953 1.60676042103196 "EZH2 MUT" "KIN001.135_IC_50" 0.0184082897893124 0.248320916765564 0.917892118644069 0.0669957222051728 0.626429322505683 0.697410934205291 0.0402952738882782 0.651924914099298 0.85973211667448 "SMARCA4 MUT" "AZD.0530_IC_50" 0.240374530881965 0.711340033600749 1.37591572409911 0.0670273746051964 0.626429322505683 1.853804662991 0.263136649554588 0.877052916121269 2.11887758688374 "NF1 MUT" "Thapsigargin_IC_50" 0.00698659251182056 0.145995124935243 1.6466061676346 0.0670796403223628 0.626429322505683 0.860008838762898 0.0136911887439685 0.482141194305023 1.58266984700724 "MET MUT" "S.Trityl.L.cysteine_IC_50" 0.182280925971031 0.658636992153339 1.97178080612245 0.0671577196884548 0.626499693858369 1.46532752803123 0.148651793348173 0.831473272394224 2.17357405469647 "GNAS MUT" "PF.02341066_IC_50" 0.137948903277214 0.606087209949663 -1.21233263175677 0.0674278332533188 0.627861458322138 -1.37496906218842 0.256237332304947 0.875707386589409 -0.934383091215118 "MSH2 MUT" "BAY.61.3606_IC_50" 0.00539259398836942 0.125370751860494 -2.01600911077697 0.0674450885304943 0.627861458322138 -0.929043261969231 0.047482984381076 0.673636396626734 -1.36333871323276 "EWS_FLI1 MUT" "NVP.TAE684_IC_50" 0.686429266442728 0.911730003936733 0.304428296319598 0.0678240434759421 0.630728094355856 1.24061537438464 0.794924136404775 0.975627957210581 -0.225618971782079 "RUNX1 MUT" "AUY922_IC_50" 0.0700904727460059 0.469083261836683 1.53837551573428 0.0679358331435672 0.631106834882867 1.03892804953843 0.0926532776283866 0.76758746139711 1.5159627851804 "FLCN MUT" "Pyrimethamine_IC_50" 0.511741674576291 0.850007572343239 -0.884893843537418 0.0680119185896988 0.631153447225826 -2.06993048440261 0.914081960871745 0.990992087087848 -0.257757438058326 "FBXW7 MUT" "Roscovitine_IC_50" 0.726840652935582 0.92560056809276 0.187988226950355 0.0681277748423914 0.631568651748724 0.879302541713388 0.588079201452951 0.949294892873838 0.301587944914067 "MET MUT" "XMD8.85_IC_50" 0.342624797121481 0.779440739135111 -1.22499051369863 0.0683242306362316 0.632729397581203 -2.01107131563387 0.43897028001377 0.923376375367667 -0.983382726607281 "PTEN MUT" "NSC.87877_IC_50" 0.189291770637404 0.664203956946181 -0.170703901079764 0.0690333056190027 0.637716331550798 -0.237178493105303 0.16777823715002 0.84067330207935 -0.198148290968782 "FGFR2 MUT" "JNK.9L_IC_50" 0.000204569904361479 0.0157981332229069 2.54379217474047 0.069116470679025 0.637716331550798 0.994031149771185 0.000877505640639729 0.155862551890429 2.60796806281423 "MDM2 MUT" "Metformin_IC_50" 0.0204095265939743 0.258938579544408 1.0633947876448 0.06911738096641 0.637716331550798 0.777882605535663 0.0398205412863664 0.650264437987822 0.919714853713678 "MS-HL MUT" "Nutlin.3a_IC_50" 0.09259964427321 0.521047790474527 -0.427411949987336 0.0691499636621347 0.637716331550798 -0.423524756382359 0.0978992925605906 0.772838770871649 -0.445157586224392 "PTEN MUT" "BMS.754807_IC_50" 0.070513970191919 0.469481816691404 0.488375562314682 0.0694083119504035 0.63920544003773 0.416866665188683 0.0894187017110674 0.760658515226043 0.487085377959505 "CCND1 MUT" "AG.014699_IC_50" 0.114726531413231 0.567167686753817 0.457685392453523 0.0694905726427076 0.63920544003773 0.4682396056561 0.686458200343441 0.961100601384891 0.11741670443516 "ALK MUT" "AG.014699_IC_50" 0.00874838477672044 0.164606790682318 -2.66154989461879 0.069527356725194 0.63920544003773 -1.63115955660541 0.0197738433055802 0.527361869059632 -2.22662861526917 "MYCN MUT" "GSK.650394_IC_50" 0.795512450160429 0.948769890110348 -0.122745371633751 0.0697122244077911 0.640034959120604 -0.566274057366945 0.0726089398195233 0.737687100586647 -0.98058911904541 "NRAS MUT" "FH535_IC_50" 0.0272423465438354 0.306640405140434 -0.56134437721406 0.0697617205752443 0.640034959120604 -0.407806850914273 0.0657724364188336 0.711992560878964 -0.512167760056531 "CDKN2A MUT" "AP.24534_IC_50" 0.00126805495690103 0.0516586975790735 -0.744090026194874 0.0698520626716524 0.640202444362173 -0.391976299421883 0.0850973100027178 0.749680540483183 -0.429712578163071 "MLH1 MUT" "Cisplatin_IC_50" 0.232823657977886 0.705702015870855 -0.602414207967704 0.0700871147764524 0.641651907775964 -0.798352111055173 0.4247236305577 0.922428741067589 -0.389558603587193 "ERBB2 MUT" "AKT.inhibitor.VIII_IC_50" 0.0922657986214475 0.520483603614995 -0.662834126704832 0.0701547125830943 0.641651907775964 -0.626800430061716 0.353719062249742 0.911252930312559 -0.378607078245338 "FGFR2 MUT" "Pazopanib_IC_50" 0.512805788307149 0.851098524753465 -0.618628472076797 0.0704000441323313 0.64227209180817 -1.47359323808547 0.242543150179123 0.875707386589409 -1.16253440887805 "KDM5C MUT" "CGP.60474_IC_50" 0.109375420815664 0.557261619917495 -1.49585941095891 0.070410382890907 0.64227209180817 -1.26101877851129 0.159183188250016 0.838901067822678 -1.27655236951351 "NOTCH1 MUT" "AZ628_IC_50" 0.281297041324512 0.738238482270387 -0.855931604460097 0.0704394794979346 0.64227209180817 -1.12837183006901 0.148636923350005 0.831473272394224 -1.14078234982624 "NF2 MUT" "Salubrinal_IC_50" 0.128192212679405 0.588664235316545 -0.840175789473685 0.0705214350255459 0.642359860986537 -0.848094938792257 0.0305208978725749 0.605035924121289 -1.30070110773263 "TSC1 MUT" "NU.7441_IC_50" 0.122539632558038 0.581032822609681 -1.5634792820513 0.0706730434380515 0.643081248743171 -1.61231511674234 0.153774264732189 0.835611501078903 -1.39134709774701 "FLCN MUT" "BI.D1870_IC_50" 0.188146298933816 0.663245512002727 -1.06216685181644 0.0708908182230352 0.64394506122294 -1.25623326791063 0.434670289629609 0.922569292988365 -0.843275928993852 "TET2 MUT" "RO.3306_IC_50" 0.334659835386797 0.773264085106582 0.820740195694729 0.0710554912033824 0.64394506122294 1.48176191361592 0.118694724388692 0.806524749270063 1.62979676944745 "MS-HL MUT" "NSC.87877_IC_50" 0.199163713705277 0.674012093366938 0.183029765624998 0.0711617860857043 0.64394506122294 0.254346202917391 0.556136382943007 0.948539891860351 0.094771681533509 "FLT3 MUT" "AZD.0530_IC_50" 0.0989620264835796 0.5374999166548 -1.93140139301803 0.0711708575081962 0.64394506122294 -1.83573299003069 0.0585207316982935 0.70215997387469 -2.09446507062143 "CDK6 MUT" "BAY.61.3606_IC_50" 0.066732514738608 0.459419739064789 1.24603023550088 0.0712180175127162 0.64394506122294 0.855928498581419 0.486636013164427 0.933639405738697 0.475333134121075 "BRAF MUT" "PD.0332991_IC_50" 0.626019902953757 0.891117608291764 -0.148810791974762 0.0713797932538152 0.64394506122294 0.473844781209072 0.418608894026808 0.922428741067589 -0.270280058949374 "GNAS MUT" "PHA.665752_IC_50" 0.0756916608265424 0.481186571081262 -1.22203097972974 0.071448451137424 0.64394506122294 -1.22997619955661 0.0496300508231436 0.679896345274018 -1.41911041659098 "CDKN2A MUT" "BI.D1870_IC_50" 0.571594637376888 0.872389778906173 -0.0795940870353717 0.0714620735297045 0.64394506122294 0.228681296647794 0.633735810633942 0.952523560833852 -0.0725153489583197 "BCR_ABL MUT" "Epothilone.B_IC_50" 0.362199853365232 0.787270200866664 1.06677189703317 0.0714974775904937 0.64394506122294 -1.45048855879315 0.241732418422414 0.875707386589409 1.3629688101276 "TET2 MUT" "GDC0941_IC_50" 0.0312468346777465 0.327244267421069 -2.26020961111106 0.0715073700931492 0.64394506122294 -1.54802892233647 0.135238883456035 0.828937189282754 -1.92246814834948 "SMARCA4 MUT" "GW843682X_IC_50" 0.526756333576159 0.855121165130409 -0.895450425170076 0.0715655641737464 0.64394506122294 -1.31264517235875 0.276446359192979 0.884207634152307 -2.73736756816359 "BRCA2 MUT" "Vorinostat_IC_50" 0.851789326438615 0.963906856282026 -0.118714501976284 0.0717757236672084 0.645182390575382 -0.875415844947328 0.32032271898381 0.900918773778407 -0.577437133375099 "CDK6 MUT" "Methotrexate_IC_50" 0.0825343949596576 0.498292292071189 1.29187930555556 0.0720156351736331 0.645199722215558 1.01560694733622 0.338410551856466 0.906340202363472 0.564115262876566 "MLL_AFF1 MUT" "BI.D1870_IC_50" 0.641995321107537 0.896094514063559 0.530004036190488 0.0720478266320363 0.645199722215558 1.79785675669795 0.130270576549382 0.824553892801908 1.65467166026262 "PIK3CA MUT" "Sunitinib_IC_50" 0.0276531175974 0.308798590144762 1.46653492824137 0.072099360961512 0.645199722215558 0.884047551398936 0.0341487815239206 0.618827479917328 1.3515662322145 "APC MUT" "RO.3306_IC_50" 0.000835917244100213 0.0397506306180868 0.918817355371904 0.0721357392009524 0.645199722215558 0.497799961593467 0.301449430115439 0.894167310052 0.349441108226629 "CDKN2A MUT" "CI.1040_IC_50" 0.000191131111641186 0.015204607912249 -0.579729557851243 0.0721408990158821 0.645199722215558 -0.260118795912323 0.676756368924093 0.960260954212314 -0.0653852443490584 "SMARCA4 MUT" "BI.2536_IC_50" 0.436212178650111 0.823808548892323 -1.02423465306123 0.0723313497390887 0.646252230415339 -1.40269461396835 0.318068227593307 0.900918773778407 -2.33586702766821 "KIT MUT" "Sorafenib_IC_50" 0.0403692260062961 0.36287357911125 -2.68148338644068 0.0727016445260864 0.647616784207117 -2.29912662716667 0.106804853567941 0.792410790279379 -2.19501916387514 "JAK2 MUT" "CCT007093_IC_50" 0.246592857364018 0.714668105985286 0.446278974524353 0.0727080058656765 0.647616784207117 0.696292009095052 0.223102717291513 0.866364334178367 0.517005384961425 "SMAD4 MUT" "Pazopanib_IC_50" 0.0203633120397847 0.258938579544408 0.830864053423113 0.0727300007462896 0.647616784207117 0.563335807789113 0.268134312813958 0.87741371853381 0.389744189505037 "PIK3CA MUT" "Pazopanib_IC_50" 0.201455737436262 0.674012093366938 0.343796162877984 0.0727757629364602 0.647616784207117 0.415185897612165 0.284957782098046 0.8879937007725 0.28850613411884 "MLLT3 MUT" "CGP.082996_IC_50" 0.10151847318423 0.542024654294532 -0.859764370629367 0.0731407721492636 0.650115024234446 -0.785700515613277 0.0885770189492808 0.758159640835928 -0.932024416000376 "MYCN MUT" "FTI.277_IC_50" 0.0100213559734395 0.177539959960772 0.659985238291115 0.0732029078070539 0.650115024234446 0.426697775627686 0.894081357020718 0.988301482344111 0.0375049291554433 "KRAS MUT" "BMS.536924_IC_50" 0.0290192511821561 0.316210068663154 -1.16681976832751 0.073392918185217 0.651151355047864 -0.748639983452897 0.147913559395291 0.831473272394224 -0.805469560845352 "EWS_FLI1 MUT" "PF.562271_IC_50" 0.982006735054866 0.996708778745401 0.00905477072310412 0.0736671122507351 0.652716461317589 0.641227153071868 0.499978885170961 0.934042323734638 0.303228699491667 "KRAS MUT" "X17.AAG_IC_50" 0.359928688706065 0.786601117838604 -0.236776101803514 0.0738001870787476 0.652716461317589 -0.431434354645367 0.613590148615724 0.950016406878704 -0.133319592758942 "ALK MUT" "BMS.536924_IC_50" 0.310456324875444 0.757046299071613 -1.26098014675768 0.0738772707360824 0.652716461317589 -1.64714000954049 0.138949229536268 0.831473272394224 -2.0368338958577 "ALK MUT" "Tipifarnib_IC_50" 0.260438792291852 0.723705201773835 1.78355759304349 0.0739058569707787 0.652716461317589 1.88293037386854 0.575100501485998 0.949294892873838 1.23215991693515 "MSH6 MUT" "CEP.701_IC_50" 0.135292320910544 0.602573270815716 -1.0482562014231 0.073936804423544 0.652716461317589 -0.916918005761976 0.120138206977959 0.80757178183218 -0.983835752978274 "KDM6A MUT" "AUY922_IC_50" 0.128165763659979 0.588664235316545 -0.639765165895859 0.0741344649392449 0.653811502607183 -0.507230120100807 0.190193532414562 0.851001889249827 -0.557557685657435 "FLT3 MUT" "BIBW2992_IC_50" 0.0549312527581461 0.418465152800335 -2.10406948986055 0.0743638883553537 0.655057527620993 -1.89430790113959 0.0623510123343241 0.702860976445846 -1.89532494975279 "FLT3 MUT" "Temsirolimus_IC_50" 0.15634710821862 0.63139838220137 1.86994026742709 0.0744549415276864 0.655057527620993 1.81437882390976 0.0199008241422962 0.528982201860999 2.92237296918562 "CDK6 MUT" "AZ628_IC_50" 0.368766578930813 0.789246419666677 -1.40637211262799 0.0744970276880084 0.655057527620993 -2.0681400601165 0.377261991176897 0.914419412871569 1.4606692571781 "NF1 MUT" "Z.LLNle.CHO_IC_50" 0.0280498022722783 0.309508303338214 1.17048472887324 0.0745797734242229 0.655136466647402 0.882112765229209 0.255481955040831 0.875707386589409 0.683011952467036 "KRAS MUT" "Pyrimethamine_IC_50" 0.0603842976026355 0.443886947376523 -0.964514690909091 0.0746688615690366 0.65527090869033 -0.832388231601268 0.174496888869642 0.84578207413725 -0.771693783361819 "NF2 MUT" "NSC.87877_IC_50" 0.211311312617225 0.685278387407167 0.310803284950344 0.0748651391699166 0.65605802959674 0.438939398553575 0.125606145794631 0.817150972850516 0.416255876407923 "MET MUT" "Lenalidomide_IC_50" 0.39542964360968 0.803801937490859 -0.26333172147002 0.0749172457312357 0.65605802959674 -0.484962617940833 0.114592973618789 0.799692247086917 -0.467817789542435 "CDKN2C MUT" "Thapsigargin_IC_50" 0.552027212915852 0.865716701025195 -0.545860536155201 0.0749801711564791 0.65605802959674 -1.24914216511974 0.242223634217772 0.875707386589409 -1.24405317407949 "MSH6 MUT" "Vinorelbine_IC_50" 0.542950010891229 0.862633715268747 0.438474381533101 0.0751217430331444 0.656454124565758 0.941286822225887 0.451861543902158 0.925809648901546 0.529464125752792 "EWS_FLI1 MUT" "A.443654_IC_50" 0.0354729252175428 0.347105523744792 1.30555723572565 0.0751732738073838 0.656454124565758 0.781103124719678 0.264345597403213 0.877052916121269 0.817330935142757 "SOCS1 MUT" "Lenalidomide_IC_50" 0.0242283448731408 0.285373913552206 -1.69065009487665 0.0752608756586061 0.656455410234945 -1.17363214844909 0.0876862320806279 0.755326311453013 -1.22778106192555 "SETD2 MUT" "Dasatinib_IC_50" 0.0499754581549057 0.398055644729792 -5.42009255102042 0.0753212547043586 0.656455410234945 -4.10129568629437 0.583650478257421 0.949294892873838 -1.33650144087403 "NF2 MUT" "Vinorelbine_IC_50" 0.564430493692075 0.871766547058339 0.259316647568118 0.0754799441837915 0.656477319783025 0.588972824997945 0.424081253839123 0.922428741067589 0.380821990762863 "CDKN2A MUT" "JNJ.26854165_IC_50" 0.00105725451573623 0.0473009282089722 -0.350753833373274 0.0755306039808385 0.656477319783025 -0.185507075933017 0.0158395079621139 0.506009605077458 -0.277054596880278 "MLL_AFF1 MUT" "BX.795_IC_50" 0.0268613352098273 0.303892379615893 -2.4993427125506 0.0756147237203126 0.656477319783025 -1.58246348115167 0.174399787555698 0.84578207413725 -1.37600390118475 "SMAD4 MUT" "EHT.1864_IC_50" 0.0490548431229148 0.394973764074892 0.501865420899853 0.0756194457986752 0.656477319783025 0.463808245585269 0.267893545497622 0.877052916121269 0.29207177665264 "SETD2 MUT" "BAY.61.3606_IC_50" 0.990117150889276 0.998036562927507 0.0167723895652183 0.0757202871560629 0.656710810774409 -1.67506557209682 0.746576719436948 0.968371047127272 -0.411221859293071 "BRCA2 MUT" "Roscovitine_IC_50" 0.236085926415304 0.70906038758165 -1.40435862068964 0.0759444240343287 0.657682622844886 -1.86283448783022 0.529269565976419 0.943054040048671 -0.757100250368368 "MSH6 MUT" "Cytarabine_IC_50" 0.321691581342602 0.762461418175513 -0.747747561029009 0.0759804493907053 0.657682622844886 -1.014522385178 0.22960456702994 0.868145256417768 -0.834481002222957 "CCND1 MUT" "AICAR_IC_50" 0.160189237932187 0.636336191287136 -0.493295854251019 0.0762029031092127 0.65843194719135 -0.56063981830402 0.451480907575214 0.925809648901546 -0.274106567796896 "KRAS MUT" "Obatoclax.Mesylate_IC_50" 0.748388341785348 0.9321790832252 -0.0880807741315586 0.0762696758543735 0.65843194719135 0.377622342339209 0.764980895850368 0.969901216545994 -0.0900823465077718 "CCND1 MUT" "CMK_IC_50" 0.122078912488494 0.580982694522287 0.776667032863848 0.0762894351604435 0.65843194719135 0.826974971601792 0.0473685761307845 0.673636396626734 1.1833089579249 "IDH1 MUT" "Bosutinib_IC_50" 0.0975790034984923 0.533291772350837 -2.1066817219048 0.0764314165662974 0.659016903422609 -1.84117866945613 0.0430381488603113 0.658180729724545 -2.39429009290818 "CTNNB1 MUT" "ZM.447439_IC_50" 0.0840522646506507 0.500926799330085 -0.805384082337321 0.0765134091583956 0.659083983254812 -0.656925198775224 0.00542456547534227 0.358956332448686 -1.33925890097237 "ERBB2 MUT" "TW.37_IC_50" 0.00954476264219477 0.172290725661243 0.887073699074079 0.0767034475882013 0.659227921217443 0.571609714847563 0.301203946891904 0.894167310052 0.36282915699624 "BCR_ABL MUT" "Embelin_IC_50" 0.187228130321398 0.662987649674773 0.946622364746964 0.0767590708962602 0.659227921217443 1.21240668000449 0.0426306121798847 0.658180729724545 1.46591128720688 "MLL_AFF1 MUT" "AZD6482_IC_50" 0.105240217464857 0.548889640439555 -2.25376047758621 0.0767961312769897 0.659227921217443 -2.11471571058494 0.0463473357070452 0.673636396626734 -2.72205696387066 "BCR_ABL MUT" "Paclitaxel_IC_50" 0.823953021872916 0.957177484110155 -0.291662204778153 0.0768727252035828 0.659227921217443 1.28938480577535 0.979146497831594 0.997827228172038 0.0348338708309173 "MS-HL MUT" "CHIR.99021_IC_50" 0.149660914386947 0.62466549367193 -0.263183638392859 0.0769012640897726 0.659227921217443 -0.308008623257475 0.027050358187519 0.588860092297546 -0.432926519447541 "FBXW7 MUT" "Shikonin_IC_50" 0.331467333426881 0.772603259108552 0.431619086688307 0.0770052403712482 0.659482680556466 0.662641717382368 0.284826248852469 0.8879937007725 0.482091682890642 "ERBB2 MUT" "JNK.Inhibitor.VIII_IC_50" 0.0165870205278514 0.235694926892558 0.672996352941174 0.0772078987683289 0.660399600127911 0.488830827298602 0.103411902707383 0.780953323081861 0.492169037463514 "MYCL1 MUT" "GSK.650394_IC_50" 0.269337291598053 0.732006752858616 -0.732947495590834 0.0773754778817996 0.660399600127911 -0.756663660279535 0.15825717149171 0.83854630828105 -1.01751661905767 "SMAD4 MUT" "Epothilone.B_IC_50" 0.0464491133347411 0.384030826498868 -0.884152060911159 0.077627110208631 0.660399600127911 -0.458619748015142 0.176727413200361 0.848618686837376 -0.62894054051095 "CCND1 MUT" "CCT007093_IC_50" 0.259731613923155 0.723189643810247 0.226203230890466 0.0776313844580941 0.660399600127911 0.359305359386959 0.221292300998926 0.864953081560998 0.267833513577297 "GNAS MUT" "SB.216763_IC_50" 0.051800763489484 0.405681287963057 1.16008394237066 0.0777341859946884 0.660399600127911 1.0113909150529 0.105328719646885 0.788057589876989 0.930628561901689 "GNAS MUT" "CCT018159_IC_50" 0.236075542335491 0.70906038758165 -0.638084097657548 0.0777616856817054 0.660399600127911 -0.881659363217903 0.215391391239524 0.860576337437605 -0.677102141180085 "CDKN2a(p14) MUT" "WZ.1.84_IC_50" 0.000237321703020834 0.017925610571305 -0.755948845833335 0.0778217854992945 0.660399600127911 -0.320752239121359 0.11021913083818 0.797376436030023 -0.358354537547338 "SMARCB1 MUT" "Bicalutamide_IC_50" 0.0444717257415732 0.376863927777587 -0.881489339130442 0.0778282040029669 0.660399600127911 -0.734033337692711 0.0411501392547632 0.658180729724545 -0.84965022337623 "NOTCH1 MUT" "GSK.650394_IC_50" 0.734321750109589 0.928593402067957 -0.179068778074867 0.0778778149955861 0.660399600127911 0.620098571404533 0.836236719192493 0.981626636221501 -0.119717685520954 "BRAF MUT" "TW.37_IC_50" 0.18550005252466 0.660621300857439 -0.26109958108431 0.0781092901083682 0.660399600127911 -0.348174788048904 0.0986834172719252 0.774133667469059 -0.367317296793371 "NRAS MUT" "BMS.754807_IC_50" 0.691747386190818 0.912974964595134 0.146257441210502 0.0781963092365193 0.660399600127911 0.557558590629486 0.685423182854344 0.961100601384891 0.167536242731306 "MYC MUT" "AZD6482_IC_50" 0.0125803365904931 0.202036110777883 0.767336556775943 0.0782830220217666 0.660399600127911 0.460795683292465 0.110362031631057 0.797376436030023 0.507418702123696 "EWS_FLI1 MUT" "BMS.509744_IC_50" 0.0732224798956518 0.477424621155859 -0.950896398601409 0.0784333623941433 0.660399600127911 -0.765406785246595 0.0244441824975058 0.569786836641336 -1.34775449987847 "FAM123B MUT" "Vinorelbine_IC_50" 0.0355972992308506 0.347105523744792 1.90758644194105 0.0784370324408095 0.660399600127911 1.17021279646038 0.098820546127011 0.774133667469059 1.4934566743465 "MLL_AFF1 MUT" "CGP.082996_IC_50" 0.0285365481022733 0.313405082763117 -2.53112044217688 0.0784508650990883 0.660399600127911 -1.74563777941619 0.0612906016145017 0.702860976445846 -2.14940699796932 "SMARCA4 MUT" "Methotrexate_IC_50" 0.0413814444831039 0.367141466987459 1.44048234663951 0.07860213710934 0.660399600127911 0.938486329716015 0.0931019431640735 0.768046723169691 1.07368441647856 "KRAS MUT" "Gemcitabine_IC_50" 0.180056527679059 0.658614416960816 -0.647274592387281 0.0787207356186493 0.660399600127911 -0.597571551626228 0.253575713166192 0.875707386589409 -0.590654036620758 "TP53 MUT" "ABT.888_IC_50" 0.383713777673265 0.798569876743396 -0.0850305405659147 0.0788424541407998 0.660399600127911 -0.150954088400373 0.03420995703867 0.618827479917328 -0.207357651698519 "MYCN MUT" "JW.7.52.1_IC_50" 0.0179321661084195 0.245008564936728 1.43460323964804 0.0789232112534088 0.660399600127911 0.659532839838911 0.869780721795172 0.98753907730331 0.122178174163406 "KRAS MUT" "CHIR.99021_IC_50" 0.0777971489297092 0.486980385654137 0.301077200487803 0.0789520191288652 0.660399600127911 0.301853529563146 0.108133555236444 0.792785095696032 0.303214237020887 "MYCL1 MUT" "VX.702_IC_50" 0.169022697078186 0.648365181185948 -0.733634720077214 0.0789531631076761 0.660399600127911 -0.762261504249531 0.17152074189312 0.842832361237713 -0.743112514001182 "ERBB2 MUT" "MK.2206_IC_50" 0.299902101462373 0.751119785777076 -0.456694187234045 0.0789790065096226 0.660399600127911 -0.637681724678067 0.221852164598429 0.865076203633533 -0.560734589951655 "APC MUT" "GSK.650394_IC_50" 0.37653871658162 0.795051761241315 -0.339675725629205 0.0789871163353172 0.660399600127911 -0.455300179429539 0.546088097592016 0.946853280734584 -0.281074108533283 "MS-HL MUT" "SL.0101.1_IC_50" 0.451632250801135 0.828509891052426 0.123026459627329 0.0790528385574451 0.660399600127911 0.250317043970479 0.0803776098826415 0.741811190933953 0.300958266256563 "MLH1 MUT" "WO2009093972_IC_50" 0.20520524177988 0.677986514972885 -0.802085296124025 0.0791026802719425 0.660399600127911 -1.00032386537689 0.0944705529531454 0.770131561879207 -1.0376006686566 "MAP2K4 MUT" "Cyclopamine_IC_50" 0.0492270355992981 0.395285084229084 1.45884448275864 0.0791585846026463 0.660399600127911 1.20484083101063 0.173322202033294 0.844239622796781 1.18189307983792 "KDM6A MUT" "Etoposide_IC_50" 0.661184196940563 0.90240922898865 0.238572393175453 0.079178546035055 0.660399600127911 0.624809101235627 0.363751359570178 0.91230607860569 0.495790516315364 "FBXW7 MUT" "RDEA119_IC_50" 0.440029689103795 0.824500931653809 -0.39359260365511 0.0791944121310917 0.660399600127911 -0.811852980783201 0.423487323076368 0.922428741067589 -0.373371093571106 "BRCA1 MUT" "Docetaxel_IC_50" 0.0291962905420321 0.316210068663154 1.97396986046512 0.0794167611003735 0.661632509692699 1.18858920365051 0.0137584068670538 0.482141194305023 2.13827301894881 "EWS_FLI1 MUT" "Methotrexate_IC_50" 0.000366731070055884 0.0244882603997466 -2.12623194485182 0.0796638221811526 0.663068795492799 -0.850080979368473 0.969475739973915 0.997173634484198 -0.0211415620302023 "MET MUT" "Salubrinal_IC_50" 0.367156853951139 0.788956157846227 -1.0997914675768 0.0799171322698975 0.66401816839496 -1.74467055729454 0.385467071886163 0.915331032347709 -1.05282752367426 "CDH1 MUT" "OSI.906_IC_50" 0.0153461258453228 0.225643946411112 1.65577985250393 0.0799799504115184 0.66401816839496 1.14490849368225 0.0493994773149524 0.679896345274018 1.44462599272606 "MLLT3 MUT" "Bryostatin.1_IC_50" 0.19192217013336 0.668023137615267 0.365427993319633 0.0800021889632482 0.66401816839496 0.459342314742886 0.0782871456608961 0.741811190933953 0.491751871955979 "NRAS MUT" "Thapsigargin_IC_50" 0.0259792442903975 0.299638530575351 -1.02450212140631 0.0801400601050285 0.664358408882489 -0.634038581580584 0.178142025261224 0.848722027112292 -0.689115788541327 "CCND3 MUT" "BMS.754807_IC_50" 0.117588542281143 0.573793320878478 -1.80576085863878 0.0801927952169832 0.664358408882489 -1.68396963982796 0.249010426498584 0.875707386589409 -1.30610649536798 "MET MUT" "Bortezomib_IC_50" 0.37298431558958 0.792457824581594 -1.42231732993198 0.0805348633596309 0.666520653795307 -2.24967242181496 0.985650689910071 0.998124818853736 -0.0273602479786376 "EWS_FLI1 MUT" "Bicalutamide_IC_50" 0.83573118641872 0.959122768755193 -0.0336520877817319 0.0806038939506992 0.666520653795307 -0.289224707364938 0.0333130792406743 0.618827479917328 -0.368901576669836 "MSH2 MUT" "Cytarabine_IC_50" 0.436917132546126 0.823808548892323 -0.586697897646414 0.0808910125653774 0.667152745860799 -0.998808801163768 0.524055314661756 0.940554660491705 -0.448255263625508 "NOTCH1 MUT" "Thapsigargin_IC_50" 0.925735132036704 0.98643792569589 0.0680068400178256 0.0809490456991205 0.667152745860799 1.0010484067578 0.928773992141086 0.994186152404781 0.0698710438656258 "TP53 MUT" "Bosutinib_IC_50" 0.988837617466803 0.998036562927507 0.00232240149896385 0.0810213991463937 0.667152745860799 -0.251195755962836 0.798731860930159 0.976360691959787 -0.0420848181747438 "SMAD4 MUT" "Rapamycin_IC_50" 0.831375209244767 0.958611936552287 0.230201152397261 0.081038502832847 0.667152745860799 1.66526264685435 0.746470484298522 0.968371047127272 0.375983339745747 "AKT2 MUT" "Bortezomib_IC_50" 0.159230905835133 0.635849673885708 2.24506226190477 0.0810654638008085 0.667152745860799 2.24213192875274 0.14129725694633 0.831473272394224 2.2397468657801 "FBXW7 MUT" "X17.AAG_IC_50" 0.121300203262499 0.580424086839576 0.724255171238788 0.0811310624400025 0.667152745860799 0.715346992889928 0.968518979171892 0.997173634484198 -0.0172230507039642 "JAK2 MUT" "BIRB.0796_IC_50" 0.296466160943018 0.747775056897173 -0.52099062699937 0.0814350882893272 0.668364066135772 -0.831199851008261 0.666484870748749 0.959230524020512 -0.234790121779221 "MSH2 MUT" "Z.LLNle.CHO_IC_50" 0.108521448391303 0.554852609765783 1.31131447766324 0.0814638924124009 0.668364066135772 1.31442164995389 0.111836408831445 0.797376436030023 1.28255923959386 "MLL_AFF1 MUT" "BMS.536924_IC_50" 0.101813336120804 0.542024654294532 -2.86288594237291 0.0815999971534195 0.668364066135772 -2.28961939571054 0.0497068084930327 0.679896345274018 -3.2640392161907 "CDH1 MUT" "Cyclopamine_IC_50" 0.0910792738579667 0.516507787943737 -1.12402989619377 0.0817720823682058 0.668364066135772 -1.09175871055243 0.0497615836536552 0.679896345274018 -1.34081431372018 "PIK3R1 MUT" "PAC.1_IC_50" 0.0285491174367032 0.313405082763117 1.34285295518454 0.0818877716186462 0.668364066135772 0.893886434464335 0.0494728185173613 0.679896345274018 1.15706208702253 "MSH6 MUT" "WH.4.023_IC_50" 0.122062165892708 0.580982694522287 -2.75850970547948 0.0819188632450042 0.668364066135772 -2.69693810645375 0.0403002790046745 0.651924914099298 -3.38735093392351 "TP53 MUT" "SB590885_IC_50" 0.00782027555333736 0.156071611661099 0.461102075296155 0.0820139889896581 0.668364066135772 0.268276406851888 0.401754884907403 0.916589616820582 0.137460714373279 "GNAS MUT" "Lapatinib_IC_50" 0.0418191465393745 0.368354819675836 -1.81880753472223 0.0820312405551777 0.668364066135772 -1.34669320140036 0.295596545301233 0.894167310052 -0.846012549870457 "NF2 MUT" "Midostaurin_IC_50" 0.0196618433738777 0.252951855857793 -0.966533406926404 0.0820422985857737 0.668364066135772 -0.557277756928951 0.843810330657109 0.983319714809839 -0.0801569754321444 "BCR_ABL MUT" "QS11_IC_50" 0.531154106434389 0.856734402332693 -0.616120500872611 0.082044091578837 0.668364066135772 -1.50984362932063 0.876702416889269 0.987838063957761 0.151938725477167 "CDKN2a(p14) MUT" "Erlotinib_IC_50" 0.000104045369301501 0.00983007366773009 -0.844589146167558 0.0821062038232325 0.668364066135772 -0.372221663949762 0.00848494787637803 0.405133452097383 -0.640944770750369 "MLH1 MUT" "CMK_IC_50" 0.626002698259953 0.891117608291764 -0.298298249999999 0.08278916862203 0.673046675279088 -0.976364947513581 0.428650410244367 0.922428741067589 -0.503359678303419 "TP53 MUT" "PD.0325901_IC_50" 0.0109422583118124 0.186024875233659 0.538478435452627 0.0829124677069587 0.673046675279088 0.363296365274308 0.0171366978211231 0.513211661128791 0.474905375577621 "KIT MUT" "Rapamycin_IC_50" 0.678087196377537 0.908720747099578 0.888274661073816 0.0830461541302764 0.673046675279088 3.25412012404536 0.314296869023999 0.900294798053993 2.19835711983227 "STK11 MUT" "DMOG_IC_50" 0.418606767813713 0.814099702076568 -0.301725896057351 0.0831949956971753 0.673046675279088 -0.582027746623518 0.118657959724877 0.806524749270063 -0.583975744824292 "MSH2 MUT" "CEP.701_IC_50" 0.216586515350574 0.689181240712449 -0.867539435686918 0.0833738511556708 0.673046675279088 -0.889614525010683 0.204464659374643 0.853446327418758 -0.813540859267768 "BRCA1 MUT" "PLX4720_IC_50" 0.044446300044597 0.376863927777587 1.90325506333971 0.083420562384444 0.673046675279088 1.45793102633627 0.0420357360156095 0.658180729724545 1.7384261242364 "MYC MUT" "Imatinib_IC_50" 0.0437923072544263 0.374825086237107 0.594802672727275 0.0834281707329276 0.673046675279088 0.518058376427597 0.0575648454122749 0.700319715214265 0.627904506470768 "KIT MUT" "X17.AAG_IC_50" 0.0571860725635149 0.430033455069073 -2.09158847036328 0.08343005547824 0.673046675279088 -1.6759925588036 0.18688411146438 0.851001889249827 -1.28517787008381 "CDK6 MUT" "Bortezomib_IC_50" 0.496320583130541 0.843896642253943 -0.888545944254837 0.0834635766665084 0.673046675279088 -1.82559022477276 0.985650689910071 0.998124818853736 -0.0273602479786376 "EWS_FLI1 MUT" "GNF.2_IC_50" 0.636796190147307 0.895268363706423 -0.181874801594893 0.0835076649489774 0.673046675279088 -0.700748848789443 0.268383957493132 0.877583919917713 -0.498773565538573 "KRAS MUT" "Dasatinib_IC_50" 0.312469870879708 0.759215564942334 0.856727098264049 0.083515081202292 0.673046675279088 1.27823049430874 0.105184450654887 0.788057589876989 1.30892391722481 "MYCL1 MUT" "JNK.9L_IC_50" 0.22576363316235 0.698134056525989 0.53038114510489 0.0840485551625597 0.676731838983402 0.590074661743073 0.328920087640336 0.902810042912437 0.46315324162991 "FBXW7 MUT" "AZ628_IC_50" 0.0674098677118837 0.460513103960953 -1.51209562966505 0.0841827542217893 0.677043146647168 -1.08693132469914 0.462702789853956 0.929276781658587 -0.546877469141023 "TP53 MUT" "MS.275_IC_50" 0.366860258969033 0.788882799008227 0.241603054915048 0.084274014098583 0.677043146647168 0.401769703312956 0.272790220919713 0.882167181782537 0.332689820532179 "MET MUT" "ABT.888_IC_50" 0.420608367949452 0.81523852373616 -0.248571761812296 0.0844294062641206 0.677043146647168 -0.449879883856137 0.104054922749576 0.78447518585652 -0.468347722262613 "CDH1 MUT" "BAY.61.3606_IC_50" 0.00610368576876368 0.135517083280976 1.75536767136152 0.0844873225907015 0.677043146647168 0.779668638421245 0.062363973588484 0.702860976445846 1.20144920273657 "GNAS MUT" "Sunitinib_IC_50" 0.252345894120354 0.717470497840808 -1.56422476564277 0.0845931713026089 0.677043146647168 -1.73664461076513 0.119854393335638 0.80757178183218 -1.86661094400528 "PIK3R1 MUT" "MS.275_IC_50" 0.673483974075285 0.908308454633653 -0.416873424137932 0.0846118823605678 0.677043146647168 -1.40661442428237 0.756977880281509 0.969901216545994 -0.315128072609952 "KRAS MUT" "WH.4.023_IC_50" 0.18359389088533 0.660385845878234 1.0237610629081 0.0846208639543246 0.677043146647168 1.22056821109997 0.131763981855637 0.824721122422311 1.18685942491207 "EGFR MUT" "BAY.61.3606_IC_50" 0.080234593468167 0.492069006956693 0.710664473552033 0.084901871074865 0.67868003331762 0.489826582724717 0.250477670084862 0.875707386589409 0.461333787583944 "CDK6 MUT" "Gemcitabine_IC_50" 0.816209670531525 0.955040590776084 -0.335360530755713 0.0851351166732153 0.679368139414081 -1.6608581059238 0.883128748825063 0.988301482344111 -0.212439609428141 "CTNNB1 MUT" "FTI.277_IC_50" 0.499719574956314 0.845174165908784 0.194513978835977 0.0852805216709395 0.679368139414081 0.450483604451574 0.369291350260249 0.913948248824328 0.275782780297068 "MYC MUT" "KIN001.135_IC_50" 0.158363927705824 0.634384322036726 0.228653839416058 0.0854416151787696 0.679368139414081 0.27960790800476 0.0835410048621997 0.746428921711055 0.277469802524302 "PIK3R1 MUT" "Bleomycin_IC_50" 0.0145111750638748 0.219273935922674 2.8629241102812 0.0854430799133636 0.679368139414081 1.64188383341409 0.0272841774795878 0.588860092297546 2.48126516585656 "MYCL1 MUT" "Vinorelbine_IC_50" 0.247659787105038 0.714668105985286 -0.746249921328664 0.0854945913995253 0.679368139414081 -0.815163169961617 0.119187570062517 0.80678720253446 -1.07887665510863 "MLH1 MUT" "AS601245_IC_50" 0.228454552044635 0.700676460618178 0.632489689675523 0.0855615694150497 0.679368139414081 0.730963638702425 0.248247617259463 0.875707386589409 0.6034513092551 "MYC MUT" "PF.4708671_IC_50" 0.0697325205857655 0.467745102207087 -0.384720514786417 0.0855623396502006 0.679368139414081 -0.361313508580242 0.114247569403055 0.799692247086917 -0.359158032657297 "MYCN MUT" "Pazopanib_IC_50" 0.0240249430356847 0.283730743483931 0.965606509874318 0.0855999265853346 0.679368139414081 0.641050650990584 0.214794133815676 0.859434499119166 0.563258238462481 "MDM2 MUT" "PF.4708671_IC_50" 0.126906652813321 0.587206821914858 -0.572853173515979 0.0857050080652743 0.679594800560447 -0.635348503961381 0.0935735338891573 0.768046723169691 -0.635797525165515 "CTNNB1 MUT" "WZ.1.84_IC_50" 0.712845606688032 0.919646314953749 0.254311103448277 0.0859179788865246 0.680162422640194 0.980308060489181 0.855045421128465 0.984631915507353 0.133358551962576 "RUNX1 MUT" "GDC0941_IC_50" 0.464311809265024 0.829490249358073 -0.769497471193407 0.0860013874389395 0.680162422640194 -1.44725536966491 0.413294886681558 0.921714070263062 -0.846832522343579 "SMARCA4 MUT" "BX.795_IC_50" 0.173057827544423 0.65113493295882 0.694686559670783 0.0860263119815933 0.680162422640194 0.671082999133487 0.220669174523373 0.864474168037968 0.628342735302545 "NF1 MUT" "Embelin_IC_50" 0.914623791875593 0.984411974629711 -0.0326612792340297 0.0860829369493951 0.680162422640194 -0.420467607505224 0.16348880588377 0.839927262232576 -0.45397148227143 "RB1 MUT" "Etoposide_IC_50" 0.294304577213907 0.747036827777118 -0.329207144503774 0.0864010633401941 0.68206919424379 -0.357941397775273 0.0188702841586787 0.516564999115032 -0.794768562159076 "FAM123B MUT" "Embelin_IC_50" 0.105983796667746 0.549516047897355 1.03831250000001 0.0865040193388538 0.682180895330985 0.879667554617079 0.147928028954513 0.831473272394224 0.932153816214309 "TP53 MUT" "Lenalidomide_IC_50" 0.391223705999885 0.80204472137234 -0.0838376741461232 0.0865832935887264 0.682180895330985 -0.153461054106018 0.0518223222524277 0.690213288728522 -0.195547800013172 "APC MUT" "Metformin_IC_50" 0.896028633122549 0.977117518088203 0.0348389108846626 0.0866456536351031 0.682180895330985 -0.446917458397392 0.34010617868234 0.907051943807165 0.306385043204246 "BRCA2 MUT" "NVP.BEZ235_IC_50" 0.00894152751152263 0.165782266868126 2.0183074785429 0.0869948656580819 0.683914604642979 0.959535951517298 0.132248154106863 0.824786416167871 1.1104123560619 "KRAS MUT" "A.443654_IC_50" 0.130562995651131 0.59349449267004 -0.664438868928169 0.0871124651440774 0.683914604642979 -0.523079178176528 0.167917732395965 0.84067330207935 -0.678500118005728 "CDKN2a(p14) MUT" "AMG.706_IC_50" 0.776530301746669 0.941591338606299 0.0330215073099649 0.087251702984261 0.683914604642979 0.191474234305182 0.113197914581755 0.799692247086917 0.189662103052105 "PIK3CA MUT" "CMK_IC_50" 0.151277079995034 0.625830613280407 0.694009391682523 0.0873070396147722 0.683914604642979 0.755670276866146 0.0833542027529198 0.746428921711055 0.938858182625529 "MS-HL MUT" "AMG.706_IC_50" 0.291285436149425 0.746581806188469 0.184469989867189 0.0873731351277828 0.683914604642979 0.275424998436891 0.0998561611925269 0.774133667469059 0.289675713760937 "EP300 MUT" "WZ.1.84_IC_50" 0.659352464409124 0.902400992643984 0.523946326530613 0.087443678920647 0.683914604642979 1.68514558918435 0.302973412401662 0.894219632947544 1.16284957288597 "MS-HL MUT" "PLX4720_IC_50" 0.292855500378338 0.747036827777118 0.266909389610388 0.0875004892141994 0.683914604642979 0.385116201395509 0.402935260754253 0.916850640727267 0.211139821529572 "MS-HL MUT" "JW.7.52.1_IC_50" 0.71017203733158 0.918723650916498 -0.169908538910506 0.0875353398516802 0.683914604642979 -0.474826076649758 0.739026744394335 0.96672489654949 -0.175601169677661 "NF1 MUT" "BI.D1870_IC_50" 0.539296374567966 0.861419263046422 -0.21060725672878 0.0876228896580294 0.683914604642979 -0.508579172296345 0.583699771085125 0.949294892873838 -0.193377879968123 "CDKN2A MUT" "BMS.509744_IC_50" 0.098992388285867 0.5374999166548 -0.343927552910051 0.0876359441598593 0.683914604642979 0.27584555248661 0.88910192747938 0.988301482344111 0.0331395876438456 "KDM6A MUT" "KU.55933_IC_50" 0.00490340974350367 0.119635115197956 -0.893510116632865 0.0877674953051548 0.684084239483078 -0.485777764795249 0.0064882212990091 0.370691368090687 -0.880706004701261 "TSC1 MUT" "VX.702_IC_50" 0.497759349777196 0.844923707565453 0.719672118320622 0.0878117366299638 0.684084239483078 1.48444724954842 0.156148141761184 0.837288218996252 1.39703211507695 "CTNNB1 MUT" "JNK.Inhibitor.VIII_IC_50" 0.0793892632492647 0.489962506543933 0.562043088895547 0.0880506378435754 0.685109155032003 0.522818513897546 0.503229952844636 0.934042323734638 0.236193721101107 "NOTCH1 MUT" "JNK.Inhibitor.VIII_IC_50" 0.941298699208078 0.989446598697723 0.0227901225285439 0.0881207030430123 0.685109155032003 0.526261856372761 0.246837940315692 0.875707386589409 0.393113930376778 "RB1 MUT" "MS.275_IC_50" 0.0946383235260057 0.526948558767685 -0.587030002444564 0.0881747285442607 0.685109155032003 -0.512435393119497 0.10890899492605 0.794794813806788 -0.690793167566636 "PIK3R1 MUT" "Metformin_IC_50" 0.322692230790197 0.764017515768525 -0.507154423076925 0.0884032066009608 0.685928051865914 -0.813804165013119 0.264489355201066 0.877052916121269 -0.559013082432464 "TET2 MUT" "IPA.3_IC_50" 0.0164628944946907 0.234306035268187 -2.85876616840879 0.088434592882161 0.685928051865914 -1.72761897735505 0.298187474598407 0.894167310052 -1.41493661797809 "FGFR3 MUT" "Cyclopamine_IC_50" 0.449459893530419 0.827800355546173 0.792940410958908 0.0885600502091447 0.68630175035551 1.63199841237122 0.335972285090064 0.905430766021494 1.01299954163115 "GNAS MUT" "EHT.1864_IC_50" 0.0852639995442588 0.503679085433888 0.731727664399092 0.0886380618538095 0.68630743445831 0.717509539442887 0.062983162694069 0.70501719149803 0.770922998296317 "MLLT3 MUT" "Elesclomol_IC_50" 0.356664862129319 0.786601117838604 0.468921169040243 0.0888966740786868 0.687497768338801 0.716115718643279 0.422332217653139 0.922428741067589 0.404160238056675 "FGFR2 MUT" "BX.795_IC_50" 0.501926181812935 0.846422209719112 -0.759872218623466 0.0890594065264204 0.687497768338801 -1.49471054181604 0.33229354640267 0.903405836635744 -1.36279246946804 "FLCN MUT" "Camptothecin_IC_50" 0.31487282597476 0.760507361295036 1.13298040571429 0.0892226384199261 0.687497768338801 1.20923205390213 0.543400638943711 0.946819908663743 0.852522849284547 "MLL_AFF1 MUT" "RDEA119_IC_50" 0.052170124359218 0.407137850996674 3.21200476831687 0.0892557693413434 0.687497768338801 2.58402158404796 0.0669780261172834 0.715802466844277 2.6244798154051 "SOCS1 MUT" "Bosutinib_IC_50" 0.0227508832320234 0.276025401616939 -2.89284024571434 0.089313207266636 0.687497768338801 -1.77408095512242 0.0599995918451339 0.70215997387469 -2.20903801141233 "EWS_FLI1 MUT" "ZM.447439_IC_50" 0.309007537876876 0.75674113273833 -0.440360255999998 0.0894905244252704 0.687497768338801 0.628290808455327 0.0860264076956864 0.750751691327456 0.814350986537817 "NRAS MUT" "NU.7441_IC_50" 0.220925512474712 0.693711036770013 -0.310682951331272 0.0895013266665411 0.687497768338801 -0.390961076789326 0.167031471655628 0.84067330207935 -0.387130901551249 "JAK2 MUT" "AZD.2281_IC_50" 0.0607097391240852 0.444487381006596 1.06705300624824 0.0895822406823848 0.687497768338801 0.729776510317803 0.350593436043466 0.910340341961272 0.509230568006517 "MYC MUT" "NU.7441_IC_50" 0.0898030102555328 0.514272513671442 0.408730699631246 0.0895850846513318 0.687497768338801 0.360430978886173 0.129423827556756 0.820423278038225 0.369539963754414 "SMAD4 MUT" "TW.37_IC_50" 0.107264098090367 0.551794991672845 0.438525818082394 0.089596730333764 0.687497768338801 0.429410389513072 0.707595529933582 0.962630898212352 0.103979770457346 "FBXW7 MUT" "Sorafenib_IC_50" 0.520088847383517 0.852599738673405 0.365531961538465 0.0896633756414795 0.687497768338801 0.937331225050564 0.180871766495202 0.848722027112292 0.814388152850074 "ERBB2 MUT" "AZ628_IC_50" 0.0323534919049174 0.3317914106323 2.89561154452055 0.0897797121397293 0.687497768338801 1.74312333410201 0.0790431955227593 0.741811190933953 2.13272954570886 "PIK3CA MUT" "Parthenolide_IC_50" 0.123120353322053 0.582542279090653 0.695720909090912 0.0897981546304481 0.687497768338801 0.710492763998594 0.24345539024098 0.875707386589409 0.59321290166562 "APC MUT" "AZD6482_IC_50" 0.0089043931752869 0.165782266868126 0.932555164545461 0.0900681151706562 0.688473332261769 0.533862799445416 0.501291913856758 0.934042323734638 0.28669145023207 "PDGFRA MUT" "SB590885_IC_50" 0.046139294351675 0.382890359661179 1.6280968737271 0.0900806229127548 0.688473332261769 1.15628826508771 0.0301924722477008 0.602560328161417 1.57370417378565 "ALK MUT" "CGP.082996_IC_50" 0.0461905808984979 0.382890359661179 1.63614174657534 0.0903372777311801 0.689841241212907 1.17185794546712 0.216588061846924 0.860576337437605 1.17440854331598 "FGFR2 MUT" "LFM.A13_IC_50" 0.00920400133097423 0.168885817810707 1.44096356893544 0.0906070517553634 0.690975411009672 0.894929121032476 0.158736807634389 0.83854630828105 0.896757423777365 "CDKN2A MUT" "ATRA_IC_50" 0.241731660102131 0.711340033600749 0.176667624708624 0.0906673153123997 0.690975411009672 0.209242223763963 0.721096934096316 0.965402608571648 0.0537667819107542 "MLH1 MUT" "RO.3306_IC_50" 0.306119440676359 0.754830733680498 -0.458239526477506 0.0907192128405897 0.690975411009672 -0.73047696860773 0.285865779811798 0.8879937007725 -0.482150639584385 "CDKN2a(p14) MUT" "BI.D1870_IC_50" 0.927065833641035 0.98643792569589 0.0131985717593298 0.0909067376897094 0.691739198696326 0.219023827623703 0.679708567463894 0.961100601384891 0.0632077700275405 "MSH2 MUT" "VX.702_IC_50" 0.00833844473227382 0.160289453825376 -1.49925925405999 0.091164805164092 0.691739198696326 -0.785593154325113 0.051379877700156 0.689395114310948 -1.0387800528466 "MYC MUT" "GDC0941_IC_50" 0.584458999283017 0.876506729771444 -0.167757279029056 0.0911891799088298 0.691739198696326 -0.417144118212196 0.721239123287652 0.965402608571648 -0.114090655973732 "BRAF MUT" "Sunitinib_IC_50" 0.227127314305089 0.699346740297147 0.643834912034635 0.0912469911713856 0.691739198696326 0.719921073168332 0.987853429723951 0.998132070308167 0.00916046940803462 "ALK MUT" "SB590885_IC_50" 0.755433886034679 0.934654823707749 0.328290233265714 0.0912833024242018 0.691739198696326 1.48799788433982 0.333088791110578 0.903569160603576 1.09748167694889 "MLLT3 MUT" "Z.LLNle.CHO_IC_50" 0.0806314207821256 0.493173311271389 -1.01774653356643 0.0913148995451686 0.691739198696326 -0.897962813321793 0.150634276566189 0.831473272394224 -0.860486955722442 "BCR_ABL MUT" "AKT.inhibitor.VIII_IC_50" 0.149604229628829 0.62466549367193 1.15668437543252 0.0914203230948749 0.691739198696326 1.40319743735449 0.148444283967008 0.831473272394224 1.15492381370217 "APC MUT" "AICAR_IC_50" 0.295069338906168 0.747036827777118 0.337584192229037 0.0914426099841782 0.691739198696326 -0.511477287759989 0.769162249579143 0.969901216545994 0.110047437714931 "FAM123B MUT" "PF.562271_IC_50" 0.0441956685508135 0.376006653842012 1.38469608145579 0.0915395937142436 0.691883516405274 0.945829668784113 0.0642631998307519 0.706338462496173 1.2674441209366 "CDK4 MUT" "WH.4.023_IC_50" 0.561621613288891 0.870491471862243 1.46204614285714 0.0917439063301069 0.692409582852311 3.70470520615963 0.291080881332644 0.891022884087089 2.4950454140644 "NOTCH1 MUT" "CCT007093_IC_50" 0.110724052667078 0.559686423710509 0.80938856502244 0.0917651254382581 0.692409582852311 0.856533109651318 0.0797358947825046 0.741811190933953 0.892148689726001 "BCR_ABL MUT" "Roscovitine_IC_50" 0.143083041774012 0.61606176606809 1.23082083333333 0.0918748096949659 0.692648713837854 1.58609580718114 0.0549472913538711 0.697305726351784 1.63759525923229 "PTEN MUT" "SL.0101.1_IC_50" 0.185258852456053 0.660550500647272 -0.20210176668874 0.0920808481328767 0.693192208097775 -0.228993349651397 0.0308450755384569 0.608744701904523 -0.344608475997496 "CCND1 MUT" "MK.2206_IC_50" 0.856629039414439 0.96514911547635 -0.0662354683982687 0.0921158970367245 0.693192208097775 -0.496301801782254 0.952670186833155 0.99568364368633 -0.0229698015926772 "KRAS MUT" "OSI.906_IC_50" 0.00909694955964951 0.167614126637443 -0.632025038975111 0.0922122581096353 0.693192208097775 -0.407162552465917 0.0344936300116816 0.618827479917328 -0.589067275314964 "CDKN2C MUT" "JW.7.52.1_IC_50" 0.272597680122806 0.734000646544246 -1.21601264604812 0.0922653432927414 0.693192208097775 -1.12880090739479 0.386139631533581 0.91566150942174 -1.18514123039053 "NOTCH1 MUT" "BIBW2992_IC_50" 0.00706100907616972 0.146642555554916 -1.37920988210821 0.0923371672311303 0.693192208097775 -0.865658484001765 0.00786973713308479 0.393484070559031 -1.36514232232797 "SMARCA4 MUT" "SB.216763_IC_50" 0.0527906275346599 0.410537270696422 0.898379326732675 0.0925531970844134 0.693523991132716 0.75000443242071 0.343325488310114 0.907180409180092 0.48465944822616 "MS-HL MUT" "AS601245_IC_50" 0.0315211377643793 0.328181974777787 -0.496004383829744 0.0926556825869885 0.693523991132716 -0.312384756605408 0.0327449995230775 0.618827479917328 -0.542184077328337 "PIK3CA MUT" "Axitinib_IC_50" 0.866637375367939 0.967996000759365 0.0436132679003388 0.0927013410950296 0.693523991132716 -0.373154663602795 0.377183523013221 0.914419412871569 0.221517008447472 "SMAD4 MUT" "BAY.61.3606_IC_50" 0.126487603756353 0.587206821914858 0.5560477451548 0.0927532067497307 0.693523991132716 0.438461022420989 0.409388007502048 0.920915626804887 0.302937304997185 "STK11 MUT" "PF.4708671_IC_50" 0.101632605962627 0.542024654294532 -0.395301508274234 0.0928106426685113 0.693523991132716 -0.399579605783138 0.0997441254127815 0.774133667469059 -0.428348345645115 "KDM5C MUT" "MG.132_IC_50" 0.236616327520835 0.709433418612578 -1.62184223728813 0.0929125780432981 0.693523991132716 -2.03887255372269 0.121281282352949 0.809590452621284 -1.95873384344504 "PIK3R1 MUT" "BMS.708163_IC_50" 0.0999225720523674 0.5374999166548 0.759578349242189 0.0929587508399616 0.693523991132716 0.780263435668803 0.188662928802894 0.851001889249827 0.614700250459966 "NRAS MUT" "PD.0332991_IC_50" 0.000386686839092255 0.0252512192498405 -1.27106038880493 0.0930060886655856 0.693523991132716 -0.501444319066979 0.00502410674763584 0.358956332448686 -1.08305674615695 "BRCA2 MUT" "Thapsigargin_IC_50" 0.0638946109607692 0.453595555509666 2.18492665966143 0.0932931773931508 0.695081131232024 1.51557327579458 0.130952482610463 0.824721122422311 1.74828446080185 "MYC MUT" "ABT.888_IC_50" 0.159828461713441 0.636336191287136 0.244208210472277 0.0938398735043444 0.697922355638063 0.246536152360371 0.191588973050777 0.851001889249827 0.222145373594251 "MYC MUT" "JNK.9L_IC_50" 0.0476928566885057 0.387166599863455 0.425723680635352 0.0940555501628847 0.697922355638063 0.283985199651481 0.0952671454836982 0.77097828178369 0.376078292342247 "RB1 MUT" "PLX4720_IC_50" 0.539056461585721 0.861419263046422 -0.165443362088974 0.0940756703668834 0.697922355638063 -0.411461502054652 0.0349627022697889 0.622161436602877 -0.571588769014798 "EGFR MUT" "SB.216763_IC_50" 0.203801248752279 0.675781408528279 0.394221512018384 0.0942111766502649 0.697922355638063 0.505501271440123 0.583209463854355 0.949294892873838 0.172255821100034 "BRAF MUT" "AZD.2281_IC_50" 0.649984349902137 0.898913406720956 0.0977813462475637 0.094233256274025 0.697922355638063 -0.300110265124188 0.383352119419236 0.915134825237766 -0.198220971474057 "CCND3 MUT" "IPA.3_IC_50" 0.0498198425675086 0.397773641559063 2.02814905933687 0.0942610474417312 0.697922355638063 1.45441742369084 0.0912929155110839 0.764454987127048 1.62429965328682 "ERBB2 MUT" "PLX4720_IC_50" 0.011441788643375 0.190289372550213 1.17508320935618 0.0944159706428126 0.697922355638063 0.711324114139148 0.166102281772882 0.84067330207935 0.62350869645622 "MET MUT" "Methotrexate_IC_50" 0.0513814547225228 0.404179538875753 1.31347356307978 0.0944238471532175 0.697922355638063 0.858458505768844 0.358025435092875 0.91161229252998 0.491196038271166 "KRAS MUT" "TW.37_IC_50" 0.00392828581924943 0.103125039542866 0.482593398891202 0.0945037058283299 0.697922355638063 0.270052166866142 0.0964654787832439 0.77097828178369 0.310462810045775 "KDM5C MUT" "A.443654_IC_50" 0.202498737566038 0.674012093366938 -1.29936844520548 0.0945347488908627 0.697922355638063 -1.10536387397608 0.294723859786602 0.894167310052 -1.08728880522066 "BCR_ABL MUT" "OSI.906_IC_50" 0.0833377127305302 0.499070955333674 1.76864185689357 0.0945735721377595 0.697922355638063 1.95692835743997 0.112320450565652 0.797376436030023 1.66117918726527 "KDM5C MUT" "Etoposide_IC_50" 0.0678037796812736 0.461747350209541 -2.24105422837374 0.0946175561522608 0.697922355638063 -1.33565838587382 0.0726579332358982 0.737687100586647 -2.07909751119392 "MS-HL MUT" "PHA.665752_IC_50" 0.162694886793196 0.638203749827904 0.324401269230768 0.0950157355712446 0.700277798844999 0.386409308469366 0.241008892757998 0.875707386589409 0.316159895894314 "SMO MUT" "BIRB.0796_IC_50" 0.153422154533759 0.627813266787222 -1.2285882857143 0.0951152560282457 0.700430007285945 -1.3677720450694 0.158444906711214 0.83854630828105 -1.19537021472929 "ERBB2 MUT" "FH535_IC_50" 0.32463126811549 0.765953850194918 -0.3853676177521 0.0952755488453091 0.700665181098162 -0.575147865859388 0.254886558878255 0.875707386589409 -0.452143386051188 "CDKN2A MUT" "ZM.447439_IC_50" 0.000316270657830629 0.0221165331668805 -0.506622906166054 0.0953517872665906 0.700665181098162 -0.195118232316547 0.000991925697852307 0.160771667262499 -0.497418899743611 "SETD2 MUT" "Imatinib_IC_50" 0.100062274705021 0.53760015829116 -1.61916119528617 0.0953838761341828 0.700665181098162 -1.63720548798907 0.179428523007037 0.848722027112292 -1.41156461212208 "EP300 MUT" "X17.AAG_IC_50" 0.0139426139806799 0.213122813704679 -3.1157078466922 0.0956273808691673 0.701703384321194 -1.86351766559386 0.0291837927047581 0.59799127175549 -2.41261898091524 "IDH1 MUT" "FH535_IC_50" 0.0929396034763653 0.521674050404563 -1.88972173565219 0.0957309888103732 0.701703384321194 -1.59723520109065 0.271963736657797 0.880932806352548 -1.19085630532141 "PTEN MUT" "PF.562271_IC_50" 0.316920117761502 0.761258739353268 -0.178487759595961 0.0958053360466618 0.701703384321194 -0.248157059732554 0.126283599495698 0.817150972850516 -0.291267721242998 "CDK4 MUT" "AZD7762_IC_50" 0.018847847581568 0.250205880974447 1.40763472179322 0.0958971661739533 0.701703384321194 0.781556358784403 0.0301068267006018 0.602204342180281 1.24659756207393 "VHL MUT" "Bryostatin.1_IC_50" 0.0274632254816305 0.307955688765607 -0.987534730228468 0.0959202689523623 0.701703384321194 -0.707213960573549 0.0529468468822979 0.694693703793562 -0.897937750258217 "BRAF MUT" "Pyrimethamine_IC_50" 0.180684321482824 0.658636992153339 -0.736890901173798 0.0961065031505188 0.702487123028607 -0.843272136987338 0.0714842637832792 0.731396021496892 -1.27544202578926 "MYC MUT" "Midostaurin_IC_50" 0.0131695589771447 0.207480784061478 0.724428396248738 0.0962925475462926 0.703268186479132 0.378966393709655 0.180238753280859 0.848722027112292 0.376857267517683 "BCR_ABL MUT" "Gemcitabine_IC_50" 0.591714373131626 0.877518816093285 -1.09052075392672 0.0967231255463274 0.705677429693086 -2.72666841809586 0.702783163447745 0.962139809888331 0.740932869537073 "MAP2K4 MUT" "Rapamycin_IC_50" 0.585772432590992 0.876506729771444 -0.953749498316493 0.0967813432458258 0.705677429693086 -2.49177730000371 0.502738690845503 0.934042323734638 -1.44707791661716 "PIK3R1 MUT" "CI.1040_IC_50" 0.0373012681365964 0.351296460573821 1.32396452509653 0.097022967302346 0.70640268740075 0.943614483947323 0.0907638327527358 0.764118629741502 0.945304451096861 "PTEN MUT" "PD.173074_IC_50" 0.0279530665629095 0.309508303338214 -0.399145630416552 0.0970651958755771 0.70640268740075 -0.262775796120083 0.0921769387644222 0.76758746139711 -0.306939756150463 "MYCL1 MUT" "WO2009093972_IC_50" 0.160844500356849 0.636336191287136 -0.971200714617148 0.0971194326445576 0.70640268740075 -1.02886374869601 0.118960776582592 0.80678720253446 -1.20582177560673 "MDM2 MUT" "Paclitaxel_IC_50" 0.143384716863275 0.61606176606809 -1.7158199520548 0.0972867517869662 0.706753532941555 -0.845714943227015 0.360128838338338 0.91161229252998 -1.07403963722173 "MLL_AFF1 MUT" "VX.680_IC_50" 0.00408888259614213 0.104965206135984 -5.31867051360546 0.0973388237326826 0.706753532941555 -2.04595169639697 0.0127352093730811 0.4776467991872 -4.78957375627192 "EZH2 MUT" "Vinblastine_IC_50" 0.46800389901476 0.831367686108334 -0.582439221374051 0.0974064096746384 0.706753532941555 -0.958694505816861 0.342259034723318 0.907180409180092 -0.713301404671763 "CDK6 MUT" "ATRA_IC_50" 0.0841838063182004 0.501096772058939 1.00018520202019 0.0977032328686177 0.707725867356523 0.754420958180907 0.331042409093016 0.902810042912437 0.493376762736977 "FLT3 MUT" "VX.702_IC_50" 0.0194540979757475 0.252787916799651 -2.02223124920334 0.0978041685362624 0.707725867356523 -1.18189409133973 0.145165457662374 0.831473272394224 -1.17991040797028 "MYCL1 MUT" "AG.014699_IC_50" 0.280558058102266 0.737882141891724 0.697395961625269 0.097845189155351 0.707725867356523 0.939431889259328 0.151475964689947 0.832016569066217 0.971019252188728 "EP300 MUT" "BMS.708163_IC_50" 0.13660693010366 0.604186327814048 1.04535553243847 0.0978591785963079 0.707725867356523 1.17668649302984 0.225200418430552 0.86643108387559 0.855687606795248 "FBXW7 MUT" "Bexarotene_IC_50" 0.203759122993924 0.675781408528279 0.443450705814902 0.098118445630327 0.708448700911963 0.515612416308902 0.203184186469235 0.852959543285214 0.441178406311488 "BCR_ABL MUT" "Methotrexate_IC_50" 0.000102283429544784 0.0097675176106153 -4.28850656941647 0.0981528520374109 0.708448700911963 -1.81001810842006 0.341643300834404 0.907180409180092 -0.866470459237655 "EWS_FLI1 MUT" "Elesclomol_IC_50" 0.000701561322698151 0.0355041590677904 -1.98867795755899 0.0981984405835634 0.708448700911963 -0.864149328781123 0.0227303324934908 0.559191365303856 -1.46177023560595 "NF2 MUT" "WH.4.023_IC_50" 0.0098682852659735 0.175984420576527 -2.93135066433565 0.0984168444461768 0.708744571054145 -1.67140355122537 0.563175876814937 0.949294892873838 -0.675579757648194 "CDKN2A MUT" "SL.0101.1_IC_50" 0.208767102905772 0.682643829494169 -0.134092893087313 0.0985219356627408 0.708744571054145 -0.159467993693799 0.195064917301878 0.851001889249827 -0.151692932222543 "CCND3 MUT" "RDEA119_IC_50" 0.204593162274099 0.676395003035772 2.10072100594062 0.0985757764128364 0.708744571054145 2.46691653595397 0.047423086011931 0.673636396626734 2.7895142403356 "MSH2 MUT" "Dasatinib_IC_50" 0.422599470286127 0.817314001657468 -1.41345625429554 0.0986485275192525 0.708744571054145 -2.40569606679238 0.0713563010940048 0.730928846615752 -2.79810307511632 "KDM6A MUT" "AZD6482_IC_50" 0.359322382547525 0.786601117838604 0.400480690348869 0.0987034011060218 0.708744571054145 0.612148267556143 0.427923799641883 0.922428741067589 0.3582485428844 "PIK3CA MUT" "VX.702_IC_50" 0.683879302883189 0.910554660150617 0.0891301444336244 0.0988207519811154 0.708744571054145 -0.297221321259105 0.437155049163021 0.922569292988365 0.173943412962564 "FLT3 MUT" "Sorafenib_IC_50" 0.0137322981532932 0.212607581866345 -2.63214693537418 0.0989328675724626 0.708744571054145 -1.70169823890892 0.0694119075967252 0.723529520383236 -2.01397989734662 "MAP2K4 MUT" "A.443654_IC_50" 0.110617668463287 0.559686423710509 1.87355683959044 0.0989486164350548 0.708744571054145 1.25453784306962 0.0739766615699 0.741621865836141 2.60767049083987 "GNAS MUT" "Camptothecin_IC_50" 0.00923585890074226 0.169120954427819 2.07730323992321 0.0989576926142483 0.708744571054145 0.831442713074844 0.0531681757784979 0.694899360941831 1.36164256011195 "CDKN2A MUT" "WZ.1.84_IC_50" 0.000494029280446567 0.0300511920523696 -0.698995768184744 0.0990915561578775 0.708825062207314 -0.290624969033493 0.348563707302496 0.909999728614578 -0.208874496812314 "FAM123B MUT" "Cytarabine_IC_50" 0.00892862651652716 0.165782266868126 2.59531202095241 0.0993003223040056 0.708825062207314 1.23940318686725 0.0150560427437706 0.492634387965361 2.26841347958138 "MLH1 MUT" "SB.216763_IC_50" 0.0472235459457281 0.384922051833884 -0.878441394300154 0.0993108994741249 0.708825062207314 -0.712567682329153 0.0860075944065526 0.750751691327456 -0.741481801726466 "KDM6A MUT" "BAY.61.3606_IC_50" 0.0868658664380663 0.508540382225753 -0.726667834618025 0.0994395643615316 0.708825062207314 -0.487307218469448 0.0342759950533059 0.618827479917328 -0.892680327484461 "HRAS MUT" "BIRB.0796_IC_50" 0.168270453622333 0.647446641789 -0.687267050543833 0.0995237289339392 0.708825062207314 -0.787811458839295 0.111619781116438 0.797376436030023 -0.784283186891872 "SETD2 MUT" "CCT007093_IC_50" 0.11546049747542 0.568406140842131 -1.12721584821428 0.0995299209463881 0.708825062207314 -1.192194601236 0.109361198703867 0.795960407011784 -1.16042593658054 "MYC MUT" "PHA.665752_IC_50" 0.0380444620129075 0.353423501188945 0.602785615942032 0.0995450802286795 0.708825062207314 0.489754367210823 0.0380359144752862 0.645472009508728 0.654634806600286 "PIK3CA MUT" "FH535_IC_50" 0.0379326167656127 0.352922011796915 -0.470788339423556 0.0996074403372062 0.708825062207314 -0.323700382792249 0.0960162110174546 0.77097828178369 -0.396893722818539 "MLH1 MUT" "Gemcitabine_IC_50" 0.145768578540599 0.619919550890177 -1.71824811415931 0.0996903501365512 0.708847077312018 -1.31284726844237 0.468999383946631 0.929276781658587 -0.806977358031938 "IDH1 MUT" "AZD6482_IC_50" 0.281274771913027 0.738238482270387 1.49995388448278 0.0998741695307731 0.709585999682237 1.92180653854471 0.185543981597465 0.851001889249827 1.8103654674223 "EGFR MUT" "Axitinib_IC_50" 0.0190715796412429 0.251111880766628 0.886469470355729 0.100097521343393 0.70982218679748 0.527202496665666 0.101711854919567 0.775001254906449 0.570221272352664 "NRAS MUT" "Bexarotene_IC_50" 0.105539839900618 0.549178497675936 -0.416128117578992 0.100109906714456 0.70982218679748 -0.388601167597973 0.240480236997635 0.875707386589409 -0.329680215827508 "KRAS MUT" "ABT.888_IC_50" 0.755953788840531 0.934654823707749 0.0387326592838692 0.100202049669628 0.70982218679748 -0.183263003460507 0.716313353630954 0.963437663728078 -0.0492378707016547 "FLCN MUT" "Shikonin_IC_50" 0.00932167735471722 0.169991409830069 2.38193549740033 0.100227116568409 0.70982218679748 1.26749983456106 0.138156310245248 0.831473272394224 1.70634277230546 "FBXW7 MUT" "TW.37_IC_50" 0.0536723902186512 0.413543213551623 0.705507221198151 0.100435204587041 0.710302864016936 0.544892755429044 0.0855113599267497 0.749680540483183 0.63075826891553 "TP53 MUT" "JNK.9L_IC_50" 0.285330136005196 0.740302864659114 0.128647354155653 0.100520232500038 0.710302864016936 0.160183048347492 0.241176333262709 0.875707386589409 0.151010316562456 "TET2 MUT" "CMK_IC_50" 0.0966244788203453 0.530359701114639 -1.6428567098976 0.100612746422352 0.710302864016936 -1.48956841749819 0.544414719928957 0.946853280734584 -0.750126582564933 "GNAS MUT" "BMS.536924_IC_50" 0.0472429947639831 0.384922051833884 -2.83649706802723 0.100639361544608 0.710302864016936 -1.74017209480881 0.101056267680997 0.774133667469059 -2.23747665426437 "SETD2 MUT" "XMD8.85_IC_50" 0.213275509976005 0.687763182315503 -1.60569030821919 0.100694888615845 0.710302864016936 -1.87141447220499 0.155054418504051 0.836658903934028 -1.82064518671792 "NF1 MUT" "Obatoclax.Mesylate_IC_50" 0.00726008464475719 0.148564082327393 1.31170003029352 0.100876364418528 0.710944120429231 0.594609209095046 0.0561760550098703 0.697813103075383 0.969879359298188 "SMARCA4 MUT" "A.770041_IC_50" 0.308788559908007 0.75674113273833 1.5089762687075 0.101015554707713 0.710944120429231 1.97827116914943 0.265126676314261 0.877052916121269 2.69350293020132 "APC MUT" "X681640_IC_50" 0.00151787838213561 0.0569603689624804 0.984843701198765 0.101025952030367 0.710944120429231 0.459501065216732 0.2006659016711 0.851001889249827 0.45685305350915 "NOTCH1 MUT" "Axitinib_IC_50" 0.691682736399649 0.912974964595134 -0.191018901803054 0.101260935686248 0.711580450761023 0.693632999656756 0.183254851325277 0.851001889249827 0.611215459928664 "BCR_ABL MUT" "BI.D1870_IC_50" 0.0379103900007165 0.352922011796915 -1.67327272657745 0.101277984873559 0.711580450761023 -1.38435789674834 0.236596790891867 0.871873900377873 -0.935086361694397 "FGFR2 MUT" "PD.0325901_IC_50" 0.0854742530397909 0.503679085433888 2.73352283762378 0.101391873778003 0.711580450761023 2.47016795597372 0.594424746335468 0.949294892873838 1.0459714943811 "FGFR2 MUT" "BMS.536924_IC_50" 0.596369743396058 0.879232253518807 0.759509564625852 0.101522493477082 0.711580450761023 -1.77106005481809 0.3420032296558 0.907180409180092 -1.57524703586402 "FGFR3 MUT" "DMOG_IC_50" 0.0432519751141753 0.374123126127403 -2.09051778929184 0.101553438983465 0.711580450761023 -1.52318978643694 0.0152712226109687 0.494977109518295 -2.3572839669465 "CTNNB1 MUT" "FH535_IC_50" 0.0328397997773102 0.334461309429233 -0.885880393238444 0.101597118743945 0.711580450761023 -0.582158027030485 0.310138520341862 0.89718581932126 -0.453787105833419 "MSH6 MUT" "Lapatinib_IC_50" 0.0799413463401728 0.491321174288633 1.56621260416666 0.102032152866164 0.714064262887632 1.25996477773622 0.211550117475246 0.855272470862467 0.97596522629281 "BRAF MUT" "Axitinib_IC_50" 0.146356231409584 0.619919550890177 0.367596462600693 0.102217782133238 0.714767849857926 0.382724756964274 0.42540816177844 0.922428741067589 0.211525984723042 "KDM6A MUT" "RDEA119_IC_50" 0.839206887660672 0.959325057190684 0.113909368779822 0.102330716345415 0.714767849857926 0.837323640572688 0.487232916560327 0.933639405738697 0.344144265092755 "KDM5C MUT" "ZM.447439_IC_50" 0.0715196910911989 0.474004758642491 -1.66517107175475 0.102536564890817 0.714767849857926 -1.1980766493545 0.0684789018507818 0.721424824836054 -1.57919581352851 "CDK6 MUT" "XMD8.85_IC_50" 0.509415296900942 0.849059439813668 -0.696820996563573 0.102585330299853 0.714767849857926 -1.47932801921405 0.43897028001377 0.923376375367667 -0.983382726607281 "NF1 MUT" "RDEA119_IC_50" 0.583460504400541 0.876506729771444 -0.279550532521088 0.102608881628785 0.714767849857926 -0.758584024588173 0.310976304763976 0.898149383211927 -0.480275849338208 "KDM6A MUT" "Doxorubicin_IC_50" 0.92566915062091 0.98643792569589 0.0404427644741355 0.102699495773797 0.714767849857926 0.442869982051335 0.846878582580775 0.98378870157398 0.0843948057755759 "PIK3R1 MUT" "GDC.0449_IC_50" 0.450398792736985 0.828077050034054 -0.328518808593748 0.102808304159723 0.714767849857926 -0.631663018670836 0.345664447301335 0.908776186051852 -0.405322485082217 "MAP2K4 MUT" "CMK_IC_50" 0.088882936351882 0.513295875726124 1.68209546302617 0.102938650669713 0.714767849857926 1.46135043457312 0.116865583865597 0.803315209218548 1.93370857162768 "NF2 MUT" "PF.4708671_IC_50" 0.072294804859717 0.474889173046706 -0.471167486338794 0.102965218351041 0.714767849857926 -0.425184619608543 0.165603309382255 0.84067330207935 -0.392537949955676 "FLCN MUT" "S.Trityl.L.cysteine_IC_50" 0.807181611479223 0.952641225877339 -0.295537348122866 0.102979484641095 0.714767849857926 -1.07270792387673 0.940404817092808 0.995120990231635 -0.162619383786194 "RB1 MUT" "CCT007093_IC_50" 0.313397619758878 0.759215564942334 0.172842194685744 0.10313442348985 0.714767849857926 0.285873481129858 0.0752455250434458 0.741811190933953 0.334548935241046 "MLH1 MUT" "TW.37_IC_50" 0.398058783738841 0.805826318300581 -0.46851412217195 0.103289386106886 0.714767849857926 -0.823936275384918 0.330343891982986 0.902810042912437 -0.51368728672385 "KIT MUT" "AKT.inhibitor.VIII_IC_50" 0.0270428130293548 0.30516800827662 -1.58684806065857 0.103341758923962 0.714767849857926 -1.00795155501987 0.059301941808336 0.70215997387469 -1.32521826205834 "MLH1 MUT" "Mitomycin.C_IC_50" 0.1408003903888 0.612364479452955 -0.951219764749271 0.103365929908657 0.714767849857926 -0.829996962571056 0.746145576313051 0.968371047127272 -0.204817131923607 "EWS_FLI1 MUT" "AMG.706_IC_50" 0.00634698282959714 0.138397665983245 -0.944973794285711 0.103365933632457 0.714767849857926 -0.560332689023333 0.0112176866001597 0.450437967177441 -0.939877875371789 "PDGFRA MUT" "PD.173074_IC_50" 0.261935801796748 0.724288808298587 -0.725830569744596 0.103420412911545 0.714767849857926 -0.900376402726781 0.441522525796505 0.924472815010418 -0.465260415881682 "VHL MUT" "Roscovitine_IC_50" 0.156995195536311 0.632778052170647 -1.37131188004614 0.103587193449926 0.715308353903082 -1.40011281594426 0.0789601891201264 0.741811190933953 -1.76570792086689 "NOTCH1 MUT" "Metformin_IC_50" 0.00140515918434688 0.0548424861786086 -1.23978991106171 0.103667584818426 0.715308353903082 -0.614785061650682 0.278990477380315 0.885713545160236 -0.44965126449974 "FGFR3 MUT" "Gemcitabine_IC_50" 0.892980604863045 0.975972789421281 0.315613486643438 0.103766638062115 0.715308353903082 2.54828826042266 0.898953300830424 0.98868164268421 0.278194089194151 "NF2 MUT" "X681640_IC_50" 0.339888313703793 0.778500909061878 -0.363987349845203 0.103916335625724 0.715308353903082 -0.533587256418052 0.22850960573687 0.868145256417768 -0.449598145429965 "FLT3 MUT" "WZ.1.84_IC_50" 0.0728897852664967 0.476682019846655 -1.73908639362911 0.104047469113019 0.715308353903082 -1.32193019124655 0.0472050414035572 0.673636396626734 -1.83868688676414 "MS-HL MUT" "GSK.650394_IC_50" 0.013176349759112 0.207480784061478 -0.660157711057862 0.104285786822916 0.715308353903082 -0.282083170930783 0.0206533570980984 0.537895789994757 -0.683455744749222 "FLT3 MUT" "AP.24534_IC_50" 0.0320665899003855 0.329610399195976 -2.97098666089966 0.104416057972517 0.715308353903082 -2.04498006116999 0.142002578912435 0.831473272394224 -1.92834606103147 "EP300 MUT" "CCT018159_IC_50" 0.0195856516758548 0.252811438707561 -1.9069489702517 0.104482048243173 0.715308353903082 -1.2389852991331 0.0228094368579873 0.559587316949682 -1.86269748853035 "NRAS MUT" "NVP.TAE684_IC_50" 0.180403774506013 0.658614416960816 0.727249657946373 0.104591600180021 0.715308353903082 0.747331174998675 0.550973120302623 0.947060194029534 0.364203360972306 "KDM6A MUT" "AZD.2281_IC_50" 0.904150392518728 0.980083424155884 -0.04580391194332 0.104651194052902 0.715308353903082 0.469073698490339 0.981764230876626 0.997977517143419 0.00791089338548268 "TSC1 MUT" "Lenalidomide_IC_50" 0.561083588036358 0.870276331255523 0.437044117647056 0.104661345466107 0.715308353903082 1.07147370919358 0.201066596998856 0.851001889249827 0.919685771978839 "MSH2 MUT" "BI.D1870_IC_50" 0.061947425291625 0.448539201336004 -1.14115646895603 0.104700685586051 0.715308353903082 -0.85618315874737 0.0585867125749467 0.70215997387469 -1.10446005044711 "CDK6 MUT" "Thapsigargin_IC_50" 0.0692689111062434 0.466280108629924 1.85854568277681 0.104764816235014 0.715308353903082 1.26404369782667 0.192299331995831 0.851001889249827 1.38692949404888 "SETD2 MUT" "Nutlin.3a_IC_50" 0.188470918724562 0.663245512002727 -1.73709248828122 0.104831793276845 0.715308353903082 -1.97380731296975 0.112737781462495 0.798150737943098 -2.02739936848841 "MAP2K4 MUT" "CCT018159_IC_50" 0.0491227958653514 0.395162635942197 0.888342558139545 0.104903486093415 0.715308353903082 0.68249356638937 0.10721412296855 0.792785095696032 0.78016656885296 "NF1 MUT" "BMS.754807_IC_50" 0.886884621299089 0.975046090834019 -0.0696857903782768 0.104907889153071 0.715308353903082 -0.664684507886678 0.852039108579446 0.984631915507353 0.0969778918542214 "MAP2K4 MUT" "AKT.inhibitor.VIII_IC_50" 0.105342895381206 0.549031839131742 -0.726628651480326 0.10491523251181 0.715308353903082 -0.623705200834287 0.258377091862107 0.877052916121269 -0.544856991221746 "FGFR3 MUT" "BMS.536924_IC_50" 0.0170040404332455 0.239702989028021 -4.1654322983051 0.104948405037239 0.715308353903082 -2.08982610097099 0.0182109105202932 0.513871228544795 -3.91256317711924 "RB1 MUT" "Obatoclax.Mesylate_IC_50" 0.0785652788404456 0.486980385654137 0.529223903368324 0.105217248811711 0.716590787344178 0.366449210870974 0.92725455218195 0.994186152404781 -0.0299485145201912 "BRAF MUT" "SL.0101.1_IC_50" 0.408608830746092 0.810304102803978 0.143304638694641 0.105346124288661 0.716918720159081 0.259689208946415 0.355489482038563 0.91161229252998 0.183578111002858 "BRAF MUT" "A.443654_IC_50" 0.563475955759216 0.871665208691448 0.265166838095239 0.1054410620514 0.716962681115828 0.518606340532621 0.597789743361284 0.949294892873838 -0.318936964136913 "CCND1 MUT" "Bosutinib_IC_50" 0.728435193109781 0.926426027496487 -0.127867127888444 0.105572392715566 0.716962681115828 -0.492733085478997 0.974099729173738 0.99742775226181 0.0119375470001545 "MLL_AFF1 MUT" "OSI.906_IC_50" 0.0379507399241137 0.352922011796915 -2.9908359408696 0.105610804242166 0.716962681115828 -2.23969668782872 0.0352787787449301 0.623237423822756 -3.06603435772794 "EWS_FLI1 MUT" "AZD7762_IC_50" 0.107832327829719 0.552948315127282 -0.777594665274306 0.105675503837475 0.716962681115828 0.65775186383174 0.456630184153467 0.925841766232465 0.378727723671738 "MLH1 MUT" "BMS.754807_IC_50" 0.168696431159433 0.647707839347554 0.923625428613576 0.105787413855084 0.717174062936643 0.917079161070049 0.242815755337855 0.875707386589409 0.77400221273908 "RB1 MUT" "IPA.3_IC_50" 0.281481961745442 0.738375640008268 0.290640792741506 0.106201400147629 0.71943145286887 0.375499007294222 0.349074431816517 0.909999728614578 0.266573164684683 "EZH2 MUT" "MS.275_IC_50" 0.0170494735256952 0.239962558449603 2.62184922508592 0.106290833188327 0.719483004777157 1.47195748305091 0.00222288600488042 0.262338505131915 3.98500961139513 "SMARCA4 MUT" "Bleomycin_IC_50" 0.341734053882691 0.778773897785973 -0.954253292643758 0.106371037639051 0.719483004777157 -1.31213279007341 0.399268940010675 0.916480913435499 -0.916140397931849 "SETD2 MUT" "KU.55933_IC_50" 0.334873748975188 0.773264085106582 0.85718224852073 0.106542073798032 0.719808760438482 1.28446914447559 0.323528363461373 0.900918773778407 0.865020647005186 "CDK4 MUT" "Gefitinib_IC_50" 0.0216325052304067 0.269073219819667 1.18762106165704 0.106606429676545 0.719808760438482 0.752014639510958 0.143162061915934 0.831473272394224 0.716089285302897 "PDGFRA MUT" "Metformin_IC_50" 0.269984209248215 0.732714976872933 -0.713421147227534 0.106711217880167 0.719808760438482 -0.972409070376941 0.0313157542826526 0.613940869280879 -1.38362585071989 "TSC1 MUT" "PD.0332991_IC_50" 0.175827437202861 0.654035305374445 -1.88880708453604 0.106743400236176 0.719808760438482 -1.7973679936048 0.443802657445746 0.925809648901546 -0.998998764555683 "BRCA2 MUT" "VX.680_IC_50" 0.753698552406985 0.933869109446012 0.585260914965987 0.107064805810551 0.720564934009506 -1.96236798617666 0.87456678872111 0.98777404048288 0.308233900102822 "MAP2K4 MUT" "MK.2206_IC_50" 0.316381560063097 0.761258739353268 -0.522614658947366 0.107118773617921 0.720564934009506 -0.671330750141689 0.0154473564578553 0.498597145349916 -1.36113107935108 "CDKN2a(p14) MUT" "Axitinib_IC_50" 0.196695311474791 0.672783946439227 -0.205302832576378 0.107195150366316 0.720564934009506 0.225639327536678 0.76983791035166 0.969901216545994 0.0456504374707547 "BRCA1 MUT" "AUY922_IC_50" 0.155402409326997 0.630721638230745 1.34860277137873 0.107312401272599 0.720564934009506 1.02766431644556 0.257365344027626 0.877052916121269 1.03512621424793 "CDK4 MUT" "BMS.536924_IC_50" 0.0513536756680458 0.404179538875753 -3.40626506101696 0.107376774879199 0.720564934009506 -2.09475066122304 0.108337953071461 0.7931981543509 -2.67841585112535 "CDK4 MUT" "Dasatinib_IC_50" 0.883564522201999 0.973927829424842 0.406274795918368 0.107411185983583 0.720564934009506 3.69180049938511 0.324053575777725 0.900918773778407 2.39214074346753 "MS-HL MUT" "AZD.0530_IC_50" 0.0965823300911445 0.530359701114639 0.569463547297297 0.107506016227605 0.720564934009506 0.477697967903104 0.0243307530696992 0.569786836641336 0.820547923934976 "EZH2 MUT" "Cytarabine_IC_50" 0.422328812643095 0.816968456781382 -0.715112362595427 0.107739536430974 0.720564934009506 -1.08211511430857 0.112550129524127 0.797731604392475 -1.30447123675571 "CDK6 MUT" "SB.216763_IC_50" 0.203238994732633 0.675511044992709 -0.622199431269217 0.107749575050709 0.720564934009506 -0.758878594128113 0.162728067583695 0.839927262232576 -0.657695928243444 "MLH1 MUT" "Nutlin.3a_IC_50" 0.037542942210419 0.352079059947973 -1.18032506669078 0.107763086337444 0.720564934009506 -0.846438266056995 0.128888662314607 0.820169751013594 -0.843054218588712 "TP53 MUT" "Metformin_IC_50" 0.478642235152183 0.836304203722611 0.0941715909090909 0.107814207567532 0.720564934009506 0.208170788096492 0.516960390763076 0.939635632721979 0.0907624821995367 "BCR_ABL MUT" "GW843682X_IC_50" 0.251568103915544 0.717470497840808 -1.4060082764505 0.107865795509102 0.720564934009506 1.29088730108666 0.450087831793051 0.925809648901546 -0.977282541591732 "SOCS1 MUT" "Gefitinib_IC_50" 0.0472141061925723 0.384922051833884 -2.27837312903225 0.107947904057936 0.720564934009506 -1.65930606407035 0.248020232623677 0.875707386589409 -1.19489403395122 "EGFR MUT" "Midostaurin_IC_50" 0.428948142413108 0.820918238409269 -0.314373689585441 0.107991434204104 0.720564934009506 -0.493713164563846 0.814689016639865 0.977383317127464 -0.0889462118058016 "BRCA1 MUT" "CMK_IC_50" 0.127291280063691 0.587259147140593 1.84422484353742 0.108171515778613 0.72122464837077 1.76919023981341 0.180825892116738 0.848722027112292 1.68005867087057 "CDKN2A MUT" "DMOG_IC_50" 0.00307190459983147 0.08828991828836 -0.442273106841784 0.108261778758975 0.721284964109869 -0.227351911682044 0.656916860404961 0.958313128388245 -0.0720151818382778 "FAM123B MUT" "Elesclomol_IC_50" 0.999166618403076 0.999548905963057 -0.00114188761904754 0.108389665397518 0.721595665963536 -1.45881789956169 0.429036633966005 0.922428741067589 -0.829067862263439 "AKT2 MUT" "AZD.2281_IC_50" 0.0931263361960526 0.521674050404563 1.12844753465348 0.108536678432168 0.721806888386766 0.813835047295282 0.0907718899197483 0.764118629741502 1.0095383666687 "CDH1 MUT" "Temsirolimus_IC_50" 0.545301844107504 0.862633715268747 -0.491322432341643 0.108606360090221 0.721806888386766 -1.00756435640474 0.174313992137501 0.84578207413725 -1.12524758404987 "CCND1 MUT" "MG.132_IC_50" 0.146836925803253 0.619919550890177 -1.10145856319444 0.10866521898132 0.721806888386766 -1.09461471022535 0.459155973659169 0.927632358897555 -0.619792305986712 "MYCL1 MUT" "OSI.906_IC_50" 0.138787833849551 0.607179680994022 -0.961626054673729 0.109023401865244 0.723267436667327 -0.982520722113426 0.390729747157673 0.915926348152589 -0.612011991213809 "CCND1 MUT" "BX.795_IC_50" 0.806068908219086 0.952641225877339 -0.080492499363058 0.109076800337553 0.723267436667327 -0.408754471402387 0.0958507351308292 0.77097828178369 -0.519138609847425 "SMAD4 MUT" "GSK269962A_IC_50" 0.335715901554281 0.773352247338781 0.850593438423642 0.109196576644844 0.723267436667327 1.36757424860931 0.523640868248056 0.940554660491705 0.596135991101564 "STK11 MUT" "Epothilone.B_IC_50" 0.967525166203616 0.994434372972651 0.0198147830018083 0.109261297882406 0.723267436667327 -0.444568444889304 0.581002559082974 0.949294892873838 0.278820130819085 "KIT MUT" "Gemcitabine_IC_50" 0.0864857424505305 0.506983418285915 -3.11656746853149 0.109292298165472 0.723267436667327 -1.96063469980842 0.0474657243115041 0.673636396626734 -3.37963273417908 "MYCN MUT" "PD.173074_IC_50" 0.616486372959584 0.885815598771911 0.160742084419972 0.10953852406399 0.724248886173063 0.448119251602613 0.0851915608061807 0.749680540483183 0.616479298264118 "IDH1 MUT" "AG.014699_IC_50" 0.0589061561908733 0.438512634644715 -1.9211339663677 0.109683108987381 0.724248886173063 -1.42362726708226 0.11517761309316 0.801639797711879 -1.49484803650672 "MSH6 MUT" "Shikonin_IC_50" 0.37064972126247 0.790333775397838 0.65175952787456 0.109752054450239 0.724248886173063 0.977437375776457 0.392210266083599 0.915926348152589 0.603917345651182 "MYC MUT" "Obatoclax.Mesylate_IC_50" 0.384276336500272 0.798569876743396 -0.317552972432716 0.109780137533652 0.724248886173063 -0.430916791572747 0.095169891182028 0.77097828178369 -0.617110028336032 "PIK3CA MUT" "PD.0332991_IC_50" 0.00232692033692415 0.0735422758442113 0.93465184590246 0.109848356004404 0.724248886173063 0.397699392369517 0.141342190332126 0.831473272394224 0.465712822531726 "TET2 MUT" "AZD7762_IC_50" 0.00583052638146367 0.132094144882089 -2.84305808333342 0.110002691515731 0.724728414948966 -1.30850190926916 0.0468746502304648 0.673636396626734 -2.29793575439576 "SMARCA4 MUT" "KIN001.135_IC_50" 0.351596206794968 0.784966682190403 0.419765990990994 0.1104904134747 0.727204267147311 0.703173604861412 0.415630151432972 0.92211126027385 0.591149238902341 "MET MUT" "Bryostatin.1_IC_50" 0.12116961692971 0.580333022534361 -0.594195327497595 0.11054225432371 0.727204267147311 -0.57858127923464 0.252423515868255 0.875707386589409 -0.420279972144644 "MLLT3 MUT" "Vinblastine_IC_50" 0.34449066592085 0.780249349533262 -0.394431373374609 0.110732934355465 0.727473329456837 -0.481551807400718 0.513200732499733 0.939635632721979 -0.268387505589075 "NOTCH1 MUT" "Bleomycin_IC_50" 0.849507351962352 0.963526482778845 0.15867262254902 0.110746981356339 0.727473329456837 1.13135625673137 0.596095847955746 0.949294892873838 0.470776510267188 "MS-HL MUT" "Vinblastine_IC_50" 0.818134195026316 0.955165737441734 0.0551423152803319 0.110874952930684 0.727533782150939 0.278745022738021 0.813967551370159 0.977383317127464 0.0578961406663148 "NRAS MUT" "Cytarabine_IC_50" 0.0127775206771709 0.204033328924638 -0.829368091917677 0.110953011353303 0.727533782150939 -0.420020148245965 0.114733121208585 0.799692247086917 -0.553967989862005 "APC MUT" "NVP.BEZ235_IC_50" 1.87223817838078e-07 5.3636604071612e-05 1.51769401274992 0.111001945142948 0.727533782150939 0.358571167199438 0.0209420069184582 0.543750293893623 0.802787922031039 "AKT2 MUT" "Thapsigargin_IC_50" 0.0567693632039315 0.429079757118396 -2.08144745814538 0.111463538740937 0.729309249459325 -1.32498469732153 0.117330559020062 0.804643007457276 -1.68349346994818 "CDKN2A MUT" "PF.02341066_IC_50" 0.0044678113550267 0.112086532892633 -0.553601588930315 0.111484289087793 0.729309249459325 -0.300937860295431 0.12788697990455 0.820169751013594 -0.337432328133289 "NRAS MUT" "Nilotinib_IC_50" 0.660778483549072 0.902400992643984 -0.121058148033016 0.111519193870709 0.729309249459325 0.36657544297305 0.348891343433351 0.909999728614578 0.264197095728619 "NOTCH1 MUT" "AKT.inhibitor.VIII_IC_50" 0.334757288701156 0.773264085106582 -0.391424917844516 0.111691616073913 0.729495164708373 -0.571148974770033 0.32076804154529 0.900918773778407 -0.43383155365593 "EWS_FLI1 MUT" "Tipifarnib_IC_50" 0.798820294565221 0.949864290255993 -0.149274536180311 0.111711904515639 0.729495164708373 0.663833682023523 0.571206781635404 0.949294892873838 0.372755462297228 "NF2 MUT" "Metformin_IC_50" 0.0750368754715544 0.480779116570693 0.570070865032399 0.11183295942124 0.72964044804536 0.478128901441012 0.186363384687997 0.851001889249827 0.443807002870692 "NF1 MUT" "Gefitinib_IC_50" 0.0437968926539252 0.374825086237107 0.711503419580416 0.111904490418808 0.72964044804536 0.506077424037163 0.333713828608899 0.903569160603576 0.326970666268241 "CDKN2C MUT" "AUY922_IC_50" 0.94932007524828 0.991438058591785 0.0383941146384474 0.112012958735864 0.72964044804536 -0.64702454934878 0.686576735309248 0.961100601384891 -0.277888434569754 "KDR MUT" "Metformin_IC_50" 0.244700925244711 0.713407507663177 -0.969386476190482 0.112062782472004 0.72964044804536 -1.23441411491213 0.0408531564612607 0.656088395176232 -1.68599536791698 "MYCN MUT" "AZD.2281_IC_50" 0.526906052580243 0.855121165130409 -0.227325599593494 0.11224566852902 0.729846336647631 0.442238228988549 0.0558714796894703 0.697813103075383 0.709070157453738 "SMAD4 MUT" "CGP.60474_IC_50" 0.763677884066677 0.936244886169491 -0.213896310430054 0.112312395582884 0.729846336647631 0.871419455237631 0.611267662743178 0.949930222127033 0.372391087051764 "CDH1 MUT" "AZD.2281_IC_50" 0.999766844952134 0.999842122472917 -0.000166533655211747 0.11234094608685 0.729846336647631 -0.694911767842139 0.139978570889209 0.831473272394224 -0.743500442297428 "RB1 MUT" "BI.2536_IC_50" 0.0428231314242069 0.372489941408797 -0.754909892510529 0.112642093738381 0.730928948220645 -0.362926923960624 0.00328406151098199 0.304990979295641 -1.32477312076541 "TP53 MUT" "RDEA119_IC_50" 0.0238688200098794 0.282638654010318 0.498110292920046 0.112672191207529 0.730928948220645 0.332892676609921 0.150055157556006 0.831473272394224 0.292372819690545 "KIT MUT" "ATRA_IC_50" 0.170184811615428 0.649721929411943 1.18650853448276 0.112914244765922 0.731403222350281 1.08172039093626 0.360875464414792 0.91161229252998 0.69878482914403 "MYC MUT" "X681640_IC_50" 0.269392642257043 0.732006752858616 0.296885941208792 0.113011272279195 0.731403222350281 0.364918756656052 0.24351787168284 0.875707386589409 0.307792187147613 "MLH1 MUT" "Bexarotene_IC_50" 0.0808257079858596 0.493903473430236 0.81700459115045 0.113092303636632 0.731403222350281 0.669114989556451 0.0822527730632757 0.745860856369627 0.781866367433336 "PTEN MUT" "Parthenolide_IC_50" 0.099834620872377 0.5374999166548 -0.405688644176704 0.113115772866478 0.731403222350281 -0.369216056406599 0.149592743586888 0.831473272394224 -0.403588506039747 "PIK3CA MUT" "Cyclopamine_IC_50" 0.114528965708019 0.567167686753817 0.660473966602792 0.113157080003298 0.731403222350281 0.609723938715917 0.249522982780085 0.875707386589409 0.530055260043286 "MS-HL MUT" "Bryostatin.1_IC_50" 0.0813439291047506 0.495483837022832 0.281540647438094 0.113458179255439 0.731526652453112 0.242857136669318 0.826836737252563 0.980698467734194 0.0376563794580699 "ERBB2 MUT" "BIRB.0796_IC_50" 0.879867739431611 0.972508449768779 0.045309411764706 0.113463321814245 0.731526652453112 -0.467295447672267 0.927652438582733 0.994186152404781 -0.0287178883408978 "FGFR2 MUT" "AG.014699_IC_50" 0.0722280882071319 0.474889173046706 1.82870639237665 0.113484427437136 0.731526652453112 1.4353399154667 0.142214826154197 0.831473272394224 1.95201682240585 "PIK3R1 MUT" "Gefitinib_IC_50" 0.0699175020558013 0.46849633115101 1.04678363435699 0.113620031239589 0.731526652453112 0.822448493689687 0.099751092502282 0.774133667469059 0.85369701711385 "TP53 MUT" "Doxorubicin_IC_50" 0.515279150528018 0.852194122611816 0.111645788334006 0.113662544033628 0.731526652453112 0.173925421005842 0.667925359435834 0.959230524020512 0.0756525892232091 "FAM123B MUT" "Docetaxel_IC_50" 0.0139139295703248 0.213122813704679 2.56649551515152 0.113746632053482 0.731526652453112 1.23984943962419 0.0815619539263557 0.742940116960579 1.76549255153874 "CDH1 MUT" "Gefitinib_IC_50" 0.140449729298646 0.611283910091978 -0.851831380038373 0.114045982050171 0.731526652453112 -0.828442490659029 0.0720413493109026 0.735136682279868 -1.00630918293157 "SMO MUT" "NU.7441_IC_50" 0.133837271209233 0.600610816376554 1.51795852859963 0.114052370350785 0.731526652453112 1.39752232348659 0.389638719049248 0.915926348152589 0.836199863509452 "MLH1 MUT" "PF.4708671_IC_50" 0.162483262873791 0.637655261856886 -0.673810520361997 0.114064838136274 0.731526652453112 -0.752883803726626 0.180259525177146 0.848722027112292 -0.651755093143066 "APC MUT" "Epothilone.B_IC_50" 0.320774738643302 0.762015213745527 -0.427719077632039 0.11417411769572 0.731526652453112 -0.405817870884049 0.265662902992724 0.877052916121269 -0.569409125971477 "PIK3R1 MUT" "Pyrimethamine_IC_50" 0.0185029929873815 0.248885968328711 2.45833051369861 0.114301066553508 0.731526652453112 1.39099077640137 0.0299588844765419 0.600597862384128 2.25183980716932 "HRAS MUT" "GSK.650394_IC_50" 0.788186349852731 0.946449577332088 -0.251136996503495 0.114395452492941 0.731526652453112 -0.957474302966333 0.888201561106351 0.988301482344111 -0.130928294825199 "FLT3 MUT" "Cytarabine_IC_50" 0.997761934210883 0.999204573800497 -0.00322220659062115 0.114397728285895 0.731526652453112 -1.38983513933942 0.614518617247326 0.950059945073224 0.537863923263255 "CCND3 MUT" "OSI.906_IC_50" 0.181996362597913 0.658636992153339 -1.36387402443284 0.114433407197486 0.731526652453112 -1.52371686922442 0.160393425646088 0.838901067822678 -1.44168553380443 "NRAS MUT" "GW.441756_IC_50" 0.174818001218508 0.652884217334553 0.277672151248795 0.114473982182332 0.731526652453112 0.326079791099077 0.721162465884545 0.965402608571648 0.0824275334132553 "CDH1 MUT" "Vorinostat_IC_50" 0.856846880442808 0.965202580569835 0.0869015007100262 0.114508044200384 0.731526652453112 -0.590479599841924 0.256392552270047 0.875707386589409 -0.501382160683024 "RB1 MUT" "Cytarabine_IC_50" 0.0162710102237754 0.233354840019847 0.661566136283765 0.114576463637234 0.731526652453112 0.33752683143084 0.227347509760364 0.867648638924452 0.341070217194392 "PIK3CA MUT" "BX.795_IC_50" 0.0509269081680717 0.40238600661979 0.468390337214084 0.114686066557523 0.731700400213623 0.294439310944546 0.745759773638432 0.968371047127272 0.0757405117118898 "MSH6 MUT" "Pazopanib_IC_50" 0.188575843749544 0.663245512002727 -0.881369920035154 0.114976657526852 0.7325232716305 -0.897702599319117 0.153208466930242 0.835611501078903 -0.86884823244851 "FGFR2 MUT" "CCT007093_IC_50" 0.242130502302893 0.711340033600749 0.838118973214284 0.114980006829514 0.7325232716305 1.14577885894874 0.264921846066312 0.877052916121269 1.14092222658799 "CDKN2C MUT" "AZD7762_IC_50" 0.157159564029262 0.632778052170647 0.89999429383429 0.115239234148306 0.733111380975226 0.785690172662062 0.0393710619365713 0.64992634601437 1.2759772030221 "SMARCA4 MUT" "BMS.708163_IC_50" 0.0894961969391295 0.514272513671442 0.658083915909093 0.115251732658774 0.733111380975226 0.610259049259712 0.121649654492795 0.809590452621284 0.693751657420441 "APC MUT" "GW843682X_IC_50" 0.985803266516849 0.996887811168928 -0.0133332342657339 0.115341455865714 0.733111380975226 0.623622994843662 0.409847264127761 0.921138279485245 0.758239143866007 "BCR_ABL MUT" "SB590885_IC_50" 0.0336173327462472 0.337822288815889 -1.93690559959354 0.115467432170335 0.733111380975226 1.48272499506287 0.471884369381555 0.929276781658587 -0.593566948623594 "EGFR MUT" "WZ.1.84_IC_50" 0.405121419448147 0.807904911469051 -0.448485384615383 0.115520385853642 0.733111380975226 -0.697736284272868 0.936022909685528 0.994729228933513 0.0415576748535864 "MDM2 MUT" "ABT.888_IC_50" 0.0359312728458985 0.347470427769827 0.70660300967118 0.115688419276372 0.733111380975226 0.447554841745571 0.0423953422600503 0.658180729724545 0.636092590120281 "BRCA1 MUT" "AZD7762_IC_50" 0.768420380627994 0.93882809194624 -0.264132660611856 0.115721028731709 0.733111380975226 -1.10554847233394 0.479540570688882 0.930304161706959 -0.575012505806409 "BRAF MUT" "AZD.0530_IC_50" 0.670384527643766 0.906882709825482 0.194733175916409 0.115760434212042 0.733111380975226 0.675666534482435 0.714066352096826 0.962630898212352 0.203888879329796 "PIK3CA MUT" "NSC.87877_IC_50" 0.0559744754193431 0.42507280266688 -0.305201409932662 0.115863842044112 0.733111380975226 -0.249450328318225 0.103037813324973 0.780118346239626 -0.290063325577969 "ALK MUT" "GDC.0449_IC_50" 0.307148549928289 0.755619465903916 0.883646467181467 0.115897801924245 0.733111380975226 1.21382558719743 0.306507550978376 0.896682870760742 0.882325290597083 "CDKN2C MUT" "Erlotinib_IC_50" 0.268407982784989 0.731654786713776 0.857967205882357 0.116055023519294 0.733583390658254 1.10054678747087 0.167131223546539 0.84067330207935 1.3432984131376 "BRAF MUT" "Obatoclax.Mesylate_IC_50" 0.000666237499063812 0.0350109776874895 -1.1055967815047 0.116273698831721 0.734059260517159 -0.413357350393525 0.00709163187518493 0.381508554648877 -1.00558389274339 "CCND3 MUT" "Bicalutamide_IC_50" 0.0594753601815741 0.439862785571841 -0.585694188481688 0.116399945071247 0.734059260517159 -0.46528421012161 0.192473754885459 0.851001889249827 -0.380104983299441 "RB1 MUT" "AZD6482_IC_50" 0.355180499188565 0.785252181551816 -0.233038593185865 0.116428461809829 0.734059260517159 -0.341842333482458 0.45482926060143 0.925809648901546 -0.209909227585138 "NOTCH1 MUT" "AG.014699_IC_50" 0.403035159027566 0.807551344312402 0.603707772522529 0.116465328857078 0.734059260517159 0.993411458200407 0.415500514792954 0.92211126027385 0.53990398099301 "MYCL1 MUT" "Bryostatin.1_IC_50" 0.0657496476667628 0.457742485196035 0.738933329276902 0.116676831431558 0.734059260517159 0.593789309347001 0.463561674621695 0.929276781658587 0.307522317149194 "MYC MUT" "CGP.60474_IC_50" 0.114083140394986 0.566018083713894 0.624509566176469 0.116681380301993 0.734059260517159 0.472583649842352 0.665431268974004 0.959206771190239 0.176980507500022 "PTEN MUT" "RDEA119_IC_50" 0.261052249120328 0.724280746538892 0.338242898103957 0.1167088926754 0.734059260517159 0.435527546909871 0.360702615330305 0.91161229252998 0.256221409758778 "SMAD4 MUT" "Erlotinib_IC_50" 0.0108448168774042 0.185216959015821 -1.66735488888889 0.116911256196405 0.734305532337021 -0.950556658558606 0.306840904288957 0.896682870760742 -0.697068451518693 "TP53 MUT" "AZD6244_IC_50" 0.0290579977418701 0.316210068663154 0.470632120680426 0.116913413210736 0.734305532337021 0.324587085445041 0.10063387496114 0.774133667469059 0.341613030094838 "FGFR2 MUT" "CHIR.99021_IC_50" 0.0827819964809323 0.498552626562699 1.24719036332179 0.117488089576985 0.737393444193076 1.08387330150222 0.302495665387798 0.894167310052 0.825486447105635 "AKT2 MUT" "GDC0941_IC_50" 0.196600882287154 0.672783946439227 1.05336733264462 0.117656085762396 0.737926340152431 1.02621777822796 0.232106989522059 0.869962136993019 0.977419045106912 "CDK6 MUT" "VX.680_IC_50" 0.126040660276856 0.586978030371663 2.32955177133106 0.118021457837884 0.739695530739767 1.54069060908641 0.267543086936619 0.877052916121269 2.13458713848727 "MLH1 MUT" "GW.441756_IC_50" 0.216044747293871 0.688608753079032 -0.458178425587923 0.118174621197462 0.740133152929945 -0.572540057414761 0.28332681945463 0.8879937007725 -0.397496688547054 "TSC1 MUT" "KU.55933_IC_50" 0.14679916987094 0.619919550890177 -1.28895049309667 0.118318799062808 0.740513921407189 -1.23834503188177 0.205668012799105 0.853446327418758 -1.10851217468823 "EP300 MUT" "GDC.0449_IC_50" 0.213778873279185 0.688117861819268 0.878985564152159 0.11848102403135 0.740562958319874 0.987310314098384 0.256356557776916 0.875707386589409 0.790762653759788 "ERBB2 MUT" "QS11_IC_50" 0.860153422244007 0.966384100200122 -0.0850613234243686 0.118493408824743 0.740562958319874 -0.569344508466655 0.153779015100839 0.835611501078903 -0.712050161357874 "CDKN2A MUT" "Z.LLNle.CHO_IC_50" 0.00279030411439878 0.0820552676820382 -0.651763534440986 0.118695127633279 0.741301989107702 -0.335128783730246 0.820649465632778 0.977383317127464 -0.0561352274689814 "MS-HL MUT" "IPA.3_IC_50" 0.00228378792529987 0.0726964894788104 -0.804669119251405 0.11891013085027 0.741610534923388 -0.348833424331906 0.0567066787197332 0.697813103075383 -0.521507183691186 "CDH1 MUT" "PF.02341066_IC_50" 0.107863327730237 0.552948315127282 -1.1768829118644 0.119082283951348 0.741610534923388 -1.07637289197993 0.0609091088272057 0.702860976445846 -1.37517664575478 "ERBB2 MUT" "NU.7441_IC_50" 0.0300580624590239 0.32084814026273 0.786595028397571 0.119266781483083 0.741610534923388 0.510500156234247 0.397673757554829 0.916480913435499 0.315024173198679 "MSH2 MUT" "IPA.3_IC_50" 0.0176433912021186 0.24368733633906 -1.85821147869676 0.119276793922115 0.741610534923388 -1.03363591720306 0.118347397448264 0.806524749270063 -1.14893975440625 "TET2 MUT" "Cyclopamine_IC_50" 0.0311007548807654 0.326856226549646 -1.84215120274912 0.119284956179565 0.741610534923388 -1.23806907904277 0.0342884546283939 0.618827479917328 -2.20930863684668 "MYCL1 MUT" "Tipifarnib_IC_50" 0.300452102276967 0.751119785777076 0.739140477954149 0.119339819757371 0.741610534923388 0.738570382393336 0.87271477874977 0.987739302532152 0.122972101872186 "RUNX1 MUT" "KU.55933_IC_50" 0.173419676767419 0.65113493295882 0.98850698287221 0.11940524149632 0.741610534923388 1.00178713856189 0.167158594260369 0.84067330207935 0.980399640171749 "CDKN2a(p14) MUT" "AZD6482_IC_50" 0.0048435323117696 0.118938844209653 -0.477020447131109 0.119523994017101 0.741610534923388 -0.234021057704253 0.50636876153405 0.935912793170426 -0.123254033776821 "MLL_AFF1 MUT" "AS601245_IC_50" 0.0673972044202625 0.460513103960953 -2.33037857739133 0.119629144735542 0.741610534923388 -1.61151253444748 0.0365842002713692 0.638141127082613 -2.64816931113073 "GNAS MUT" "AZD.0530_IC_50" 0.116193512900181 0.570433713690719 -1.59563997118645 0.119776320441541 0.741610534923388 -1.36139306010511 0.25106055292644 0.875707386589409 -1.12868858983865 "MSH2 MUT" "WH.4.023_IC_50" 0.399650248740134 0.805918367644724 -1.34823681786942 0.120034842748812 0.741610534923388 -2.17078483407587 0.185918374087786 0.851001889249827 -2.00305030879542 "NF2 MUT" "PAC.1_IC_50" 0.0719541865596899 0.474889173046706 0.689493152963349 0.120232307470933 0.741610534923388 0.503604911156032 0.0808645523751619 0.741811190933953 0.695310800687149 "NF2 MUT" "GNF.2_IC_50" 0.0148668704692352 0.221903658213912 -0.977453472027966 0.120387035816329 0.741610534923388 -0.608569230015238 0.382567321635885 0.915134825237766 -0.392051753222846 "CDK4 MUT" "S.Trityl.L.cysteine_IC_50" 0.261420837832642 0.724288808298587 -1.66098490816327 0.120456559343567 0.741610534923388 -1.26367089576644 0.378093315658813 0.914597095447912 -1.33467991233453 "CCND2 MUT" "FTI.277_IC_50" 0.10896897397686 0.555860688046234 1.02123147841104 0.120457515500807 0.741610534923388 0.895625407489904 0.546282882279391 0.946853280734584 0.446253899564676 "BRAF MUT" "PF.02341066_IC_50" 0.247473428738275 0.714668105985286 0.425177054275472 0.120614225052342 0.741610534923388 0.5734349043548 0.243018756564311 0.875707386589409 0.543804919498671 "EGFR MUT" "Lapatinib_IC_50" 0.257032678994765 0.721462459593081 -0.648967269503547 0.120706578293431 0.741610534923388 -0.758093680275049 0.69967306438445 0.961100601384891 0.196025765370698 "BCR_ABL MUT" "CHIR.99021_IC_50" 0.193273396988062 0.668382680609485 -0.935838269896185 0.120800260514922 0.741610534923388 1.27661162087242 0.121636816115469 0.809590452621284 -1.09485155118452 "CCND2 MUT" "Epothilone.B_IC_50" 0.261674388995322 0.724288808298587 1.51579467944249 0.120805127899889 0.741610534923388 1.18676627432172 0.333877585012993 0.903569160603576 1.55546974457509 "EP300 MUT" "BMS.536924_IC_50" 0.96535678263238 0.994434372972651 0.0761706847457629 0.120811441067692 0.741610534923388 2.00840372224748 0.567552976550653 0.949294892873838 0.950774639640407 "TP53 MUT" "AZD6482_IC_50" 0.490634704163269 0.84270247622041 0.118855851829333 0.120823051420725 0.741610534923388 0.235826909421432 0.276902810755295 0.884350551395532 0.197497740895765 "KDM6A MUT" "Bryostatin.1_IC_50" 0.314421079059098 0.760194346847454 0.28180163788969 0.120835570538148 0.741610534923388 0.411641906580618 0.358845072922553 0.91161229252998 0.260110615606036 "NF2 MUT" "PHA.665752_IC_50" 0.0309855448777447 0.326432531505636 -0.947133344827593 0.120905169713817 0.741610534923388 -0.691826135322891 0.179074032910571 0.848722027112292 -0.663322062133736 "PTEN MUT" "AMG.706_IC_50" 0.248557854477441 0.715413140877926 -0.186847503183922 0.121001704659331 0.741610534923388 -0.236133975811726 0.631779172495595 0.952523560833852 -0.0780323581313964 "EGFR MUT" "Erlotinib_IC_50" 0.279497912357143 0.737882141891724 -0.629556699834161 0.121051931758474 0.741610534923388 -0.808460900210297 0.807498514280828 0.977383317127464 -0.140377730671568 "STK11 MUT" "Paclitaxel_IC_50" 0.549566303437989 0.864873049004332 0.70273852054794 0.121090715987952 0.741610534923388 0.798010826122761 0.628493939147 0.952175822853038 0.64683072221939 "ERBB2 MUT" "AP.24534_IC_50" 0.0200781303552577 0.256936420295451 1.58036039770951 0.121323750845739 0.741610534923388 0.977530408937489 0.168771304310206 0.84067330207935 0.93421403118739 "ALK MUT" "MG.132_IC_50" 0.145724421881049 0.619919550890177 1.99244318644067 0.121344640273634 0.741610534923388 1.87783620030814 0.143590039154158 0.831473272394224 2.28568488824102 "NRAS MUT" "X17.AAG_IC_50" 0.853690822966688 0.964541653680809 0.0690085038058471 0.121373749476791 0.741610534923388 0.527063659269781 0.811455100553549 0.977383317127464 0.0892878116014979 "CDH1 MUT" "FH535_IC_50" 0.508799813678342 0.848726038823513 -0.352840710485136 0.121426503096567 0.741610534923388 -0.718841313512454 0.51902280593872 0.939635632721979 -0.353020865131385 "CCND3 MUT" "CI.1040_IC_50" 0.0862440660845476 0.506600429428132 2.17031784160304 0.121501768965318 0.741610534923388 1.74895598885173 0.0294838122152044 0.59799127175549 2.41328022774585 "IDH1 MUT" "Obatoclax.Mesylate_IC_50" 0.585331505343569 0.876506729771444 0.890026516521745 0.121536081674159 0.741610534923388 1.84284344336308 0.340505235796319 0.907180409180092 1.50015169848256 "EGFR MUT" "MS.275_IC_50" 0.0453371259109178 0.38006499344648 1.40779509473684 0.121537422986007 0.741610534923388 0.896658629341484 0.0338849420201697 0.618827479917328 1.56502537703711 "JAK2 MUT" "Gemcitabine_IC_50" 0.0472320803988335 0.384922051833884 3.05283097393489 0.121660849617875 0.741610534923388 1.5916393240485 0.0532070223443807 0.694899360941831 3.0292586435051 "JAK2 MUT" "CMK_IC_50" 0.132400018584361 0.598394180685857 1.48850001365187 0.121667216460238 0.741610534923388 1.39072172185504 0.0710833772824495 0.730661427830364 2.25411233359914 "BCR_ABL MUT" "Obatoclax.Mesylate_IC_50" 0.162310234478354 0.637610023074489 1.61342895200701 0.121903651842842 0.742052569476575 1.56810961267293 0.0119858869127366 0.459749370120074 2.83149125248919 "BRCA2 MUT" "AUY922_IC_50" 0.201759346128924 0.674012093366938 0.991303554582609 0.12190684594824 0.742052569476575 0.811366160922365 0.4905460294483 0.933639405738697 0.5167982911268 "STK11 MUT" "CCT018159_IC_50" 0.179833531324477 0.658614416960816 -0.405968105515586 0.122024541840501 0.742184519446635 -0.432506856548341 0.12362192621486 0.814000156875798 -0.499212867061824 "VHL MUT" "Lapatinib_IC_50" 0.0645250599797837 0.455884691869896 -1.90533269896195 0.122196626468604 0.742184519446635 -1.39264516080757 0.477096256257472 0.930206773177301 -0.669826965983728 "STK11 MUT" "AICAR_IC_50" 0.0932954384348678 0.522089974001299 0.626228406804467 0.122301034634355 0.742184519446635 0.516454552296528 0.0733575256267574 0.739487156743738 0.685314741318929 "BRCA1 MUT" "IPA.3_IC_50" 0.538894504296844 0.861419263046422 -0.636322144851669 0.122349928979174 0.742184519446635 -1.3445237345299 0.181629096788522 0.84916206298285 -1.2941082352775 "PTEN MUT" "Shikonin_IC_50" 0.119363310941224 0.577057450057752 -0.369988925670501 0.122357428408229 0.742184519446635 -0.31479906128944 0.085454174573168 0.749680540483183 -0.433809344376275 "CDKN2A MUT" "BIRB.0796_IC_50" 0.719128092416115 0.92132587844031 0.0382351667005201 0.122472922802974 0.742184519446635 0.163184318090035 0.268309202625083 0.877583919917713 0.132679005829049 "EWS_FLI1 MUT" "EHT.1864_IC_50" 0.0017519955543995 0.0615512814037141 -1.10793439535294 0.122517658941591 0.742184519446635 -0.609186556200497 0.924711581264191 0.994026707431102 -0.0423220503965814 "MET MUT" "RO.3306_IC_50" 0.0206213560069331 0.260139577695416 1.03432153262246 0.122597082538927 0.742184519446635 0.660170695860414 0.0602989887164795 0.702533085254831 0.83842199121243 "MET MUT" "NU.7441_IC_50" 0.0319586665987167 0.329263246012996 0.933327841182925 0.122821271795064 0.742760763131494 0.591861896199886 0.132532266951179 0.825399062267475 0.629059035618734 "MLH1 MUT" "NU.7441_IC_50" 0.705484948370619 0.916377035534646 0.164810316538884 0.1228595384574 0.742760763131494 0.597423332840439 0.471443619978412 0.929276781658587 0.306497749769428 "KDM5C MUT" "NVP.TAE684_IC_50" 0.39339623177947 0.803073858340542 1.05408079054055 0.123106037441633 0.743656989281852 1.56891563998124 0.499859800056602 0.934042323734638 0.83260287313235 "FGFR2 MUT" "AZD6482_IC_50" 0.00867875421464153 0.16428668414208 2.5815419602076 0.123175254051751 0.743656989281852 1.3031562860769 0.138245939927314 0.831473272394224 1.64502925895005 "CCND3 MUT" "WO2009093972_IC_50" 0.105983876773889 0.549516047897355 1.76347022119817 0.123338509689591 0.744136755810635 1.50714383896094 0.0587537380216456 0.70215997387469 2.02202573327339 "ERBB2 MUT" "MS.275_IC_50" 0.168755153446779 0.647707839347554 1.51738595189004 0.123466373536545 0.744199123446253 1.4368233327445 0.0754148422132691 0.741811190933953 2.1111455047328 "MS-HL MUT" "AZD7762_IC_50" 0.155737853441286 0.631267857787339 -0.340350824131088 0.123516440486407 0.744199123446253 -0.289646021191525 0.661560976808861 0.958689538788368 -0.104536325917882 "BRCA1 MUT" "WZ.1.84_IC_50" 0.268994442940643 0.732006752858616 -1.31271353741497 0.123671815787443 0.744630098988663 -1.51853638141456 0.219152702283644 0.861955336129779 -1.4048739526461 "MYC MUT" "Thapsigargin_IC_50" 0.381847770387515 0.798569876743396 -0.398779300670675 0.123838294498092 0.745023480490854 -0.537898289885098 0.16102312220011 0.839927262232576 -0.656255023846076 "GNAS MUT" "Elesclomol_IC_50" 0.116831966249155 0.572187234713762 1.21552142322456 0.123954196562465 0.745023480490854 0.989302963301824 0.259615129913774 0.877052916121269 0.82481657659098 "PTEN MUT" "A.443654_IC_50" 0.133583209772148 0.600164731037035 -0.478822042338709 0.12415469629775 0.745023480490854 -0.323669650979365 0.29373326483375 0.894167310052 -0.370015086807315 "MDM2 MUT" "BMS.509744_IC_50" 0.176453030519395 0.655133513395796 -1.05448667808219 0.124187040861716 0.745023480490854 -0.889471077992279 0.118047062730938 0.806524749270063 -1.19805459508683 "MAP2K4 MUT" "BX.795_IC_50" 0.0517085477196623 0.405674569168128 0.906554553719008 0.124228501473118 0.745023480490854 0.553228225794707 0.763076798257398 0.969901216545994 0.137283357577829 "MAP2K4 MUT" "Bosutinib_IC_50" 0.109484150900225 0.557261619917495 0.83898052944983 0.12424048807645 0.745023480490854 0.662367920758258 0.401388420013972 0.916589616820582 0.450993581143698 "TET2 MUT" "BMS.509744_IC_50" 0.184412074997677 0.660385845878234 -1.33221778911566 0.124603252698138 0.746660013194714 -1.15361685723115 0.252546491132742 0.875707386589409 -1.37623839603644 "SMAD4 MUT" "KU.55933_IC_50" 0.0998109395085055 0.5374999166548 0.415325346392737 0.124783513458766 0.746660013194714 0.354621491435917 0.257804935414261 0.877052916121269 0.299817592154658 "SMAD4 MUT" "AZD.0530_IC_50" 0.0365239815106766 0.349245910703174 -1.61116279011741 0.125015572715008 0.746660013194714 -1.04802566724844 0.487724872458823 0.933639405738697 -0.534976759378728 "PIK3CA MUT" "NVP.TAE684_IC_50" 0.245541585778974 0.714359708232298 0.807504310372557 0.12503345367488 0.746660013194714 0.876495123856343 0.233987024045208 0.869962136993019 0.908687064539331 "MSH6 MUT" "Dasatinib_IC_50" 0.200737375964082 0.674012093366938 -2.51488777397263 0.125033737559868 0.746660013194714 -2.48308095989732 0.0382863475878642 0.645472009508728 -3.511819799446 "MYCL1 MUT" "CEP.701_IC_50" 0.0881160813657332 0.511142337432447 1.1203630071977 0.125142765415268 0.746660013194714 0.736817718556313 0.165913212012057 0.84067330207935 0.904777517460161 "VHL MUT" "Gemcitabine_IC_50" 0.368179421680536 0.789246419666677 -1.29801379305799 0.12516407684508 0.746660013194714 -1.48963144597235 0.464451891485434 0.929276781658587 -1.07125247399081 "GNAS MUT" "CMK_IC_50" 0.0379275808760926 0.352922011796915 -2.04971696018201 0.125185988024651 0.746660013194714 -1.38722949986291 0.0547733175261922 0.697305726351784 -1.95336597682139 "NOTCH1 MUT" "Cyclopamine_IC_50" 0.00400451584080849 0.103752852411227 -1.29822685512368 0.125466090546047 0.747121576035051 -0.666069703083285 0.0254363669682207 0.578483940084869 -1.16807976022183 "HRAS MUT" "FH535_IC_50" 0.219544049509795 0.692453909775927 0.876165851398593 0.125480345496376 0.747121576035051 0.940836749224943 0.0382145293991224 0.645472009508728 1.41502924549742 "MYCL1 MUT" "Obatoclax.Mesylate_IC_50" 0.236219734018754 0.70906038758165 0.869755250440923 0.125515751767177 0.747121576035051 0.824897192615835 0.789595737362556 0.975393509832241 0.205405190321944 "MET MUT" "EHT.1864_IC_50" 0.168063332901806 0.647446641789 0.556994090909093 0.12574775833912 0.747626163213699 0.61249466951606 0.345656037547195 0.908776186051852 0.369174582198671 "SOCS1 MUT" "RDEA119_IC_50" 0.0435432877708289 0.374825086237107 -3.3384352316832 0.125768887269594 0.747626163213699 -2.2908200443914 0.00052696207074989 0.124761436977535 -4.87412375444193 "MYCN MUT" "DMOG_IC_50" 0.0566192088456348 0.428656313249563 0.794622155744608 0.125919080369792 0.748018296163292 0.58565301749824 0.574605216217001 0.949294892873838 0.255225548265528 "KDM5C MUT" "SB.216763_IC_50" 0.319632602781851 0.761442367303009 1.02561805068226 0.126262813066113 0.749558852165877 1.5308552291159 0.252656655894115 0.875707386589409 1.12850154471504 "NOTCH1 MUT" "VX.680_IC_50" 0.00235858142921785 0.074016118985455 -2.43748248835723 0.126371482898558 0.749702832078889 -0.835623136515198 0.00441980589381501 0.347668977848085 -2.71696752291802 "KIT MUT" "Metformin_IC_50" 0.159807693537133 0.636336191287136 -1.01511049618321 0.126523173724391 0.750101672794603 -1.03053151163197 0.0263969396295131 0.585472903331568 -1.58202639602706 "CTNNB1 MUT" "PD.0332991_IC_50" 0.308130138533713 0.756423880316111 0.612299543353703 0.126797931036871 0.751229103094363 0.732818026364214 0.576921126119317 0.949294892873838 0.348369650398684 "TP53 MUT" "JNJ.26854165_IC_50" 0.0953149018672201 0.528067151268111 0.190251429597541 0.127272837113591 0.75198609375281 0.168318890510573 0.150420153067803 0.831473272394224 0.167181273456649 "MS-HL MUT" "AKT.inhibitor.VIII_IC_50" 0.0257583799481881 0.298253158174522 -0.454059059765628 0.127335196582007 0.75198609375281 -0.268346840121722 0.003823841118704 0.323164298789642 -0.638829734109781 "STK11 MUT" "AMG.706_IC_50" 0.768950966749273 0.938868331695358 -0.0820841888396164 0.127412046453026 0.75198609375281 -0.39341413705679 0.244608996132115 0.875707386589409 -0.321892353618268 "ERBB2 MUT" "GDC0941_IC_50" 0.708200808192348 0.917841100717424 -0.172782975158563 0.127458357764759 0.75198609375281 -0.582583239501849 0.297017389417735 0.894167310052 -0.509031297956341 "STK11 MUT" "Axitinib_IC_50" 0.911481396653969 0.982267477694927 -0.043055066612874 0.12748390039536 0.75198609375281 -0.49871316653811 0.427620335082176 0.922428741067589 -0.288250760541351 "FLT3 MUT" "Paclitaxel_IC_50" 0.263317676703779 0.725551143932877 -1.6887926054422 0.127495800677589 0.75198609375281 1.02447803429023 0.298890296964851 0.894167310052 -1.57641821664881 "FLCN MUT" "ZM.447439_IC_50" 0.426591239403717 0.81941696345643 -0.637622550980394 0.127518416528739 0.75198609375281 -0.969467664616601 0.389378064815948 0.915926348152589 -0.919106040556916 "CDK4 MUT" "AZD.0530_IC_50" 0.597775920999662 0.879232253518807 0.756705457912453 0.127788313475746 0.752704590147749 1.89276178080635 0.438124486774538 0.922689961357523 1.05239836915597 "SMAD4 MUT" "Lenalidomide_IC_50" 0.689299839829544 0.912184753021336 -0.0838392024494615 0.127809764884901 0.752704590147749 -0.287673666717631 0.468765131111308 0.929276781658587 -0.154664594568372 "CDKN2A MUT" "PAC.1_IC_50" 0.272689480927107 0.734000646544246 0.159216971561771 0.128475799882882 0.755250101680099 0.194138996172998 0.361952955007126 0.91161229252998 0.146055701361498 "NOTCH1 MUT" "AMG.706_IC_50" 0.660768068617942 0.902400992643984 -0.152484922857142 0.128515383924137 0.755250101680099 0.506194552281799 0.791583936154372 0.975393509832241 0.092199306151594 "KIT MUT" "IPA.3_IC_50" 0.220479239391962 0.693369732662895 1.13528189860141 0.12863661393826 0.755250101680099 1.18409969843904 0.348461339478199 0.909999728614578 0.809184837916549 "MYCL1 MUT" "Bexarotene_IC_50" 0.0913092249827347 0.516507787943737 0.86411414285715 0.128696572054558 0.755250101680099 0.692684870342362 0.972150045859296 0.99742775226181 0.0186622955509393 "CCND1 MUT" "GW.441756_IC_50" 0.518670823784709 0.852547767172312 -0.160826109126985 0.128830341061158 0.755250101680099 -0.37308551472171 0.967028357871503 0.997173634484198 -0.0110195775419408 "BCR_ABL MUT" "Bexarotene_IC_50" 0.105786083903543 0.549414384425186 -1.30201292495639 0.128878073774207 0.755250101680099 -1.3054017274872 0.164300567749639 0.839927262232576 -1.090671881058 "MAP2K4 MUT" "PD.173074_IC_50" 0.0880247681979937 0.511142337432447 0.716830378486061 0.129041059173764 0.755250101680099 0.546135910780836 0.463725176919992 0.929276781658587 0.31395523016077 "PIK3R1 MUT" "PF.02341066_IC_50" 0.566904025902027 0.872389778906173 -0.419922911864406 0.129044504665156 0.755250101680099 -1.02365837626747 0.611695241347024 0.949930222127033 -0.361855414292367 "FGFR3 MUT" "JNJ.26854165_IC_50" 0.285343958610272 0.740302864659114 0.861999820627787 0.129056637079901 0.755250101680099 1.1421168452605 0.184067033714586 0.851001889249827 1.01093420441017 "SMAD4 MUT" "AZD6244_IC_50" 0.179875909791638 0.658614416960816 -0.628438285097188 0.129181763326509 0.755250101680099 -0.663724419962674 0.233911960777225 0.869962136993019 -0.533096750759698 "FLT3 MUT" "Axitinib_IC_50" 0.411619949360442 0.812480994891775 0.845140466413168 0.1291835251393 0.755250101680099 1.33182862520437 0.080707232658726 0.741811190933953 1.58399629164999 "EZH2 MUT" "FH535_IC_50" 0.308824242505489 0.75674113273833 -0.615009118045121 0.12926248784526 0.755250101680099 -0.782203140335614 0.193366026313753 0.851001889249827 -0.809963624629416 "FAM123B MUT" "Metformin_IC_50" 0.519259534355712 0.852599738673405 -0.465748664122142 0.129561560827788 0.756439159050928 -1.0214426447806 0.588586032922854 0.949294892873838 -0.389197609222236 "RB1 MUT" "Bleomycin_IC_50" 0.0675545687919195 0.461146906564979 0.787462263061143 0.129722950414797 0.756439159050928 0.545528005638129 0.79029733395501 0.975393509832241 0.125457082793043 "MYCN MUT" "GW.441756_IC_50" 0.271000546130891 0.733767027496476 -0.312667769969038 0.129853128542178 0.756439159050928 -0.437855780496809 0.0341611243526776 0.618827479917328 -0.698562065661446 "BRCA1 MUT" "Cisplatin_IC_50" 0.0657294882716098 0.457742485196035 1.52911237714288 0.129861628593854 0.756439159050928 1.08751719579239 0.0806375571775528 0.741811190933953 1.38530059414787 "MYCN MUT" "VX.702_IC_50" 0.708373655356112 0.917841100717424 0.130971910100695 0.130040033240529 0.756439159050928 0.446705387638366 0.0196299672299098 0.526688033138457 0.888669443850735 "MAP2K4 MUT" "PD.0325901_IC_50" 0.104215052290134 0.546977702834026 -1.06506390303029 0.130342270908239 0.756439159050928 -0.932111202947302 0.931408361552336 0.994235539701634 -0.054766534274153 "EP300 MUT" "X681640_IC_50" 0.216269591160352 0.688666274325955 -1.16697147967483 0.130359768267407 0.756439159050928 -1.22563632675658 0.0955539276843268 0.77097828178369 -1.46627765977834 "FGFR3 MUT" "PD.0325901_IC_50" 0.228786815846748 0.700881583834069 1.91434135247527 0.130361541523429 0.756439159050928 2.25799569735404 0.15148866030628 0.832016569066217 1.98963324179955 "BRAF MUT" "WH.4.023_IC_50" 0.952870876899973 0.992561499112566 0.0475166625108225 0.130388250334905 0.756439159050928 1.150345373554 0.536194815273116 0.943443271455699 0.598617783716422 "CCND1 MUT" "Pyrimethamine_IC_50" 0.966135804760128 0.994434372972651 -0.0334124652777779 0.130452182494815 0.756439159050928 -1.02244133598628 0.656855351106925 0.958313128388245 -0.41754713374699 "CCND3 MUT" "BI.D1870_IC_50" 0.14919351408345 0.624539492844318 1.64287746476194 0.130482284878451 0.756439159050928 1.48590920217084 0.196057158378008 0.851001889249827 1.38969294456768 "FBXW7 MUT" "KU.55933_IC_50" 0.330961854745202 0.772603259108552 -0.278249018404908 0.130488097248736 0.756439159050928 -0.385620696556591 0.226195669482304 0.866628015820684 -0.360915551601449 "CDKN2a(p14) MUT" "EHT.1864_IC_50" 0.0609281835783025 0.44571927377175 0.227853802387186 0.130626330797832 0.756645015278227 0.188571033083886 0.963922523013532 0.997051031866061 -0.00597002580307903 "EZH2 MUT" "GDC0941_IC_50" 0.328415217106463 0.769814166739703 0.890742946391737 0.13074526239959 0.756645015278227 1.10026019807219 0.504319777496091 0.93503055238173 0.603421876678831 "CDKN2A MUT" "Erlotinib_IC_50" 0.000395826300236298 0.0254734302347722 -0.755194036431732 0.130779202618183 0.756645015278227 -0.312739508029514 0.0541655062228118 0.697305726351784 -0.465008791532647 "TET2 MUT" "Docetaxel_IC_50" 0.709390209083135 0.918499371481488 0.39000215602837 0.131053019298492 0.757352112112857 1.19797151907953 0.542377288731711 0.945765861891114 0.755390119481894 "BRCA2 MUT" "PF.562271_IC_50" 0.041662575369905 0.368164509313559 1.2805853107639 0.131082450492276 0.757352112112857 0.778993270274268 0.0561353440025462 0.697813103075383 1.19046241679169 "FLCN MUT" "Gefitinib_IC_50" 0.0671737658412272 0.460513103960953 1.48937759238096 0.131157251258819 0.757352112112857 1.10355120564867 0.51317365587414 0.939635632721979 0.67674329334317 "CDKN2C MUT" "Vorinostat_IC_50" 0.193962119782534 0.669007940801379 0.585450123505978 0.131320608983479 0.757435679833878 0.520370009905778 0.139881477255035 0.831473272394224 0.649492017934831 "KDR MUT" "Gemcitabine_IC_50" 0.126940196872223 0.587206821914858 -3.57702553774676 0.131386036499769 0.757435679833878 -2.36748351756921 0.084339110091622 0.747749574262573 -3.82627603852866 "FGFR2 MUT" "Axitinib_IC_50" 0.216096452520129 0.688608753079032 -1.55732352561669 0.131427585026912 0.757435679833878 -1.61266158823959 0.470628749483239 0.929276781658587 1.12606361386424 "MLH1 MUT" "Metformin_IC_50" 0.126036708853016 0.586978030371663 -0.670597872340415 0.131664795044861 0.757685710910112 -0.623304966518898 0.611999670986387 0.949930222127033 -0.220101767630273 "STK11 MUT" "Vinorelbine_IC_50" 0.936317461379618 0.988343059935435 -0.0337266733870971 0.131786612594212 0.757685710910112 -0.467495203464779 0.776769429009319 0.972337708041191 0.125178037785435 "MLLT3 MUT" "Etoposide_IC_50" 0.74374171239468 0.929570057037101 0.174016135714284 0.131813591342923 0.757685710910112 0.521420515943039 0.303309476927711 0.894622967627816 0.54074413386612 "KDM5C MUT" "JNK.Inhibitor.VIII_IC_50" 0.128953327290894 0.59032706168579 -1.00324782442751 0.131882914171551 0.757685710910112 -0.949949521513295 0.154495449248008 0.835611501078903 -0.941644528818709 "HRAS MUT" "CCT007093_IC_50" 0.191104149380401 0.666489819470635 -0.594329662921353 0.131930491893859 0.757685710910112 -0.692080846121757 0.120350787048902 0.80757178183218 -0.713711913623578 "NF2 MUT" "Dasatinib_IC_50" 0.00478806531346498 0.118778793432633 -3.52449094405593 0.132015014130591 0.757685710910112 -1.59032463478244 0.989586914673213 0.998596878102629 0.0156570046277024 "ERBB2 MUT" "Cyclopamine_IC_50" 0.280876953256472 0.737978092452245 0.801779827586209 0.132199220576935 0.757685710910112 1.0482625831217 0.233048395792449 0.869962136993019 0.922299474379179 "VHL MUT" "GNF.2_IC_50" 0.0545632866954617 0.417578033589978 -1.08366657388317 0.132216749629112 0.757685710910112 -0.819570538068011 0.390621400514138 0.915926348152589 -0.576953996064445 "MYCL1 MUT" "WZ.1.84_IC_50" 0.122712697576738 0.58154293872946 1.06450052873564 0.132238807781857 0.757685710910112 0.877068931486366 0.521135583199493 0.939635632721979 0.439004823702997 "JAK2 MUT" "Obatoclax.Mesylate_IC_50" 0.04088978633921 0.364967027616607 1.78757716641607 0.132446044891374 0.75819809502836 0.967220957215651 0.075854007829769 0.741811190933953 1.61975011330046 "PIK3R1 MUT" "AICAR_IC_50" 0.0781465615194238 0.486980385654137 1.07482918297456 0.132510690816758 0.75819809502836 0.821001972126539 0.113326111190665 0.799692247086917 0.924683686785376 "TP53 MUT" "KU.55933_IC_50" 0.164395863260123 0.640350728777697 -0.163387147194811 0.132594055518975 0.75819809502836 -0.16353580775729 0.0823480733853592 0.745860856369627 -0.21598991158378 "MLH1 MUT" "AICAR_IC_50" 0.554862273499577 0.867253053669437 0.308577809591979 0.132747058110479 0.75819809502836 0.710980984408644 0.15097129879155 0.831473272394224 0.727441195334243 "SMARCA4 MUT" "Bryostatin.1_IC_50" 0.139298986214039 0.608499182243643 -0.566846027947321 0.132755099399741 0.75819809502836 -0.540670021002746 0.0618286569932684 0.702860976445846 -0.768259727555427 "ALK MUT" "AKT.inhibitor.VIII_IC_50" 0.110954531300269 0.560516036676727 1.80599080862069 0.133062396329465 0.758932574401661 1.45905761709636 0.5818814951355 0.949294892873838 0.859528900322196 "EWS_FLI1 MUT" "X681640_IC_50" 0.38440335807657 0.798569876743396 -0.384472416394412 0.133206946516607 0.758932574401661 0.611352435462838 0.30079638283752 0.894167310052 0.499357883054543 "BRCA1 MUT" "PAC.1_IC_50" 0.591764462288333 0.877518816093285 -0.464397349040148 0.133233853116534 0.758932574401661 -1.08845033710498 0.273525144934361 0.882167181782537 -0.920620633424122 "RB1 MUT" "AS601245_IC_50" 0.983951169269539 0.996723172778267 0.00473958174702011 0.133299422517077 0.758932574401661 -0.287029156233253 0.143763159161029 0.831473272394224 -0.386087927059448 "MYCN MUT" "Obatoclax.Mesylate_IC_50" 0.143337003060211 0.61606176606809 0.76641035278276 0.133393352431144 0.758932574401661 0.586631442605759 0.855438575541764 0.984631915507353 0.106285915028147 "CTNNB1 MUT" "NVP.BEZ235_IC_50" 0.365532850354093 0.787984332414431 0.425510033676852 0.133396436059114 0.758932574401661 0.509820012490746 0.531884397771488 0.94320946427311 -0.309683565719121 "APC MUT" "Rapamycin_IC_50" 0.466611228004054 0.830828665219814 -0.674375782006921 0.133513387448575 0.758946180873399 -1.22154910710072 0.647607168832359 0.957449344088104 -0.502502151372862 "CDK6 MUT" "JNJ.26854165_IC_50" 0.317045672442572 0.761258739353268 -0.406405636363637 0.133581139662179 0.758946180873399 -0.565375969512516 0.2604560357561 0.877052916121269 -0.430375598458299 "MET MUT" "SB590885_IC_50" 0.866018586053667 0.967800561563183 0.0980994176954738 0.133655199514243 0.758946180873399 -0.731644871146178 0.961465789854037 0.996625877572729 -0.0244709276283884 "CTNNB1 MUT" "AKT.inhibitor.VIII_IC_50" 0.0951090263079182 0.527890690029858 -0.698333634920629 0.133998570038489 0.758974663592953 -0.537314066819247 0.370619047343772 0.913948248824328 -0.411357743098862 "MSH6 MUT" "Bosutinib_IC_50" 0.0358256035790355 0.347105523744792 -1.43233997060438 0.134013333363397 0.758974663592953 -0.83817818050965 0.0106828066080559 0.450367315182713 -1.60144583164476 "NOTCH1 MUT" "X17.AAG_IC_50" 0.0897561933773569 0.514272513671442 1.00740456307437 0.134257531829661 0.758974663592953 0.805865954215212 0.52806375316463 0.942849656585259 -0.358807162542299 "ERBB2 MUT" "PD.0325901_IC_50" 0.0810452614748423 0.494604003028992 0.965564036254496 0.134278951808687 0.758974663592953 0.80340294169736 0.066483443355844 0.713091135801027 0.948691610188936 "NOTCH1 MUT" "AUY922_IC_50" 0.608275597578902 0.884201147390986 0.24603812811943 0.134303347158692 0.758974663592953 0.492676309764069 0.500456369323784 0.934042323734638 0.340677495524721 "TP53 MUT" "Camptothecin_IC_50" 0.0731199160721576 0.477132971812514 0.370501924386877 0.134398965132152 0.758974663592953 0.206208203168186 0.3717798348414 0.913948248824328 0.175289385312072 "CDKN2A MUT" "PF.562271_IC_50" 0.000438401475565597 0.0274186162288596 -0.44967675679294 0.134548913144635 0.758974663592953 -0.162527731102072 0.136582297643209 0.830541253822459 -0.215170621652486 "CDKN2A MUT" "Elesclomol_IC_50" 0.161162644231235 0.636692812908184 -0.266113622138395 0.134603909946791 0.758974663592953 0.245937008409959 0.949590379701124 0.995668765770473 -0.0129108464316358 "FAM123B MUT" "AZD7762_IC_50" 0.0107446299667435 0.184249532340571 2.2813277217973 0.134646494073828 0.758974663592953 1.04852674496806 0.016789022304705 0.513211661128791 1.97664140767298 "ERBB2 MUT" "AZD8055_IC_50" 0.911911189521003 0.982611413993695 0.0387444292917163 0.134683223126011 0.758974663592953 -0.420385218137861 0.33309614573011 0.903569160603576 -0.349963864221514 "BRCA1 MUT" "A.443654_IC_50" 0.319267492978563 0.761311064402907 -1.43190695918368 0.134724076955072 0.758974663592953 -1.39209123607615 0.367720142380938 0.913948248824328 -1.34063847238726 "FBXW7 MUT" "PF.02341066_IC_50" 0.0135480387964272 0.210718270667374 -1.35225243642613 0.134726226148131 0.758974663592953 -0.768349307612061 0.0917616391162411 0.765916463337723 -0.931777052182571 "FGFR3 MUT" "PF.562271_IC_50" 0.0895915705036045 0.514272513671442 -1.50623402590671 0.1348256307399 0.758974663592953 -1.08170149493358 0.0952256875985651 0.77097828178369 -1.44898026917354 "EP300 MUT" "A.443654_IC_50" 0.97213001260413 0.995220468612913 -0.0502715850340136 0.135016772319078 0.758974663592953 1.39122194923791 0.939338704274277 0.994831655017307 0.111878015204952 "ALK MUT" "MS.275_IC_50" 0.236006423771819 0.70906038758165 -1.5067614372146 0.135034846972871 0.758974663592953 -1.57776755477304 0.227540552976003 0.867648638924452 -1.95663517040969 "CDKN2a(p14) MUT" "Elesclomol_IC_50" 0.212642937459904 0.687025177307701 -0.24276864386714 0.135225646550689 0.758974663592953 0.251329428509345 0.944417455397368 0.995333788087439 -0.0143305802505645 "PIK3R1 MUT" "BIBW2992_IC_50" 0.256193113693177 0.720311238267775 -0.766717960652582 0.135320299348637 0.758974663592953 -0.966159060554036 0.201376392490362 0.851001889249827 -0.793930312552545 "NRAS MUT" "PF.562271_IC_50" 0.558718975445474 0.869163612542691 0.143743807671958 0.135327152603155 0.758974663592953 0.30781670201807 0.568188535167315 0.949294892873838 0.157496115838406 "SMARCA4 MUT" "Parthenolide_IC_50" 0.136536196942363 0.604186327814048 1.37484092342343 0.13543386277188 0.758974663592953 1.28169101394197 0.302260823495045 0.894167310052 1.68367424687391 "APC MUT" "TW.37_IC_50" 0.00116525717612739 0.0492792808627971 0.85020915714286 0.135506633940317 0.758974663592953 0.374372653528635 0.0649037198635024 0.711617205071315 0.564487487940043 "PTEN MUT" "A.770041_IC_50" 0.438658966923408 0.824054351147029 0.312038011546185 0.135523968919551 0.758974663592953 0.496939675810611 0.138132374372449 0.831473272394224 0.612002718966792 "SMAD4 MUT" "Gemcitabine_IC_50" 0.302881630908832 0.752537231223384 -0.795256593757873 0.135803633652498 0.758974663592953 -0.790896376267593 0.207709479685951 0.853446327418758 -0.977831414312019 "CTNNB1 MUT" "AG.014699_IC_50" 0.0642352909017985 0.454771088100903 -0.777200341743131 0.13584780539977 0.758974663592953 -0.554114066328285 0.00572435300882163 0.360553043059184 -1.18772266872096 "CTNNB1 MUT" "TW.37_IC_50" 0.0709910231793828 0.471770411289663 -0.711634090214079 0.135922419271033 0.758974663592953 -0.533967855694132 0.0890395794833772 0.758159640835928 -0.711573777715063 "GNAS MUT" "Pazopanib_IC_50" 0.452970131754525 0.828509891052426 -0.450984814462081 0.136018378537787 0.758974663592953 -0.761983819536509 0.179110633193581 0.848722027112292 -0.742586623883069 "SMARCA4 MUT" "Temsirolimus_IC_50" 0.600593967537387 0.880741900288913 -0.381152119460502 0.136130060457377 0.758974663592953 -0.824121382788515 0.496491685623407 0.933676180352967 -0.535947556427925 "FGFR3 MUT" "Thapsigargin_IC_50" 0.0661007210520629 0.458177989025628 -3.05670295121948 0.136235487403297 0.758974663592953 -1.88987138802807 0.0581550975370129 0.70215997387469 -3.05232470876031 "NRAS MUT" "AMG.706_IC_50" 0.44428151028973 0.825606373270691 0.176480188370188 0.136248206608311 0.758974663592953 0.328710753810367 0.110649720086794 0.797376436030023 0.388467270980653 "MSH2 MUT" "Shikonin_IC_50" 0.973138106550946 0.995472410100622 -0.0245226977351905 0.136263909288059 0.758974663592953 0.917877520409916 0.990091303931737 0.998637236822005 0.00889680355979773 "MET MUT" "IPA.3_IC_50" 0.0878977431348649 0.511142337432447 -1.07107315354964 0.136283218374429 0.758974663592953 -0.787956790810225 0.0026955361733652 0.272034735859731 -1.7482755691404 "CDKN2C MUT" "FTI.277_IC_50" 0.132215879961972 0.597866206691587 0.528627003496505 0.136339217864127 0.758974663592953 0.478332450374542 0.0600720844625704 0.70215997387469 0.747236532771699 "NF2 MUT" "Camptothecin_IC_50" 0.133575118953421 0.600164731037035 -0.749863828927631 0.136394951367453 0.758974663592953 -0.473536994143748 0.391797650888092 0.915926348152589 -0.404111500721387 "BRAF MUT" "Lapatinib_IC_50" 0.66077986245241 0.902400992643984 0.185441116252169 0.136539444652835 0.759302948003647 0.589436810923763 0.714060156725259 0.962630898212352 0.176473163908951 "MS-HL MUT" "TW.37_IC_50" 0.0980528290198976 0.535222602658703 -0.346938241617996 0.136790589283568 0.760158441620786 -0.284049175519955 0.00663663185749568 0.370691368090687 -0.589487101678017 "MS-HL MUT" "SB.216763_IC_50" 0.069395112711991 0.466280108629924 -0.357262240262051 0.136864468883193 0.760158441620786 -0.283231999306369 0.110709663678959 0.797376436030023 -0.331704380307127 "SMARCA4 MUT" "AUY922_IC_50" 0.460590959024819 0.828966839128293 -0.425249207677484 0.136987665173093 0.7603671590014 -0.572162075840785 0.731234375181147 0.96639568318693 -0.212594850105391 "MLLT3 MUT" "Salubrinal_IC_50" 0.313287348943856 0.759215564942334 -0.557514035087721 0.137088741360395 0.76045291194358 -0.670854085914095 0.328597591594723 0.902810042912437 -0.566879631946072 "BRCA1 MUT" "AZ628_IC_50" 0.111777550802547 0.563072279454009 -3.03794499659865 0.137193866526032 0.76053076208617 -2.11067559205085 0.0491485476973456 0.679896345274018 -3.28061146252557 "PIK3CA MUT" "DMOG_IC_50" 0.291274746823612 0.746581806188469 0.269749326599329 0.137274047024449 0.76053076208617 0.345118366440389 0.825691904863763 0.980029315589217 0.0583171497852885 "TSC1 MUT" "RO.3306_IC_50" 0.167810596414271 0.647446641789 1.43498347656248 0.137416545952702 0.760845601375278 1.47457551097909 0.179000417898989 0.848722027112292 1.39512048160448 "EWS_FLI1 MUT" "Gefitinib_IC_50" 0.558138476729757 0.86900908342163 0.257514897087384 0.137808117697207 0.762183215727212 0.625935492231184 0.189738446477988 0.851001889249827 0.599382601495723 "BRCA1 MUT" "Bexarotene_IC_50" 0.199618067444334 0.674012093366938 1.03294898603841 0.138064454106175 0.762183215727212 1.06577558332383 0.266840968357409 0.877052916121269 0.860591367582456 "CDK4 MUT" "JNJ.26854165_IC_50" 0.586931231397305 0.876506729771444 -0.197905936073058 0.138161680666519 0.762183215727212 -0.503919635183078 0.767790668510586 0.969901216545994 -0.106627252847607 "PTEN MUT" "PD.0332991_IC_50" 0.874360041225434 0.971134508019394 0.0415272254101353 0.138417346481855 0.762183215727212 0.317223098790297 0.587097567576363 0.949294892873838 0.144901927530688 "CDKN2C MUT" "Shikonin_IC_50" 0.688886491834272 0.912045458255839 -0.26122852867133 0.138610473331984 0.762183215727212 -0.815851784150621 0.781029654758549 0.973017078278378 -0.211148370536688 "KIT MUT" "CCT018159_IC_50" 0.335159627309543 0.773264085106582 0.684424999999997 0.138689880146199 0.762183215727212 0.982356846873855 0.37892249766933 0.915134825237766 0.635062406199545 "EZH2 MUT" "OSI.906_IC_50" 0.247610104321708 0.714668105985286 0.895653869172946 0.138932659726969 0.762183215727212 1.07935785530788 0.480318942451804 0.930304161706959 0.591541488310529 "JAK2 MUT" "FH535_IC_50" 0.426626815748211 0.81941696345643 -0.480502898245622 0.139297129139329 0.762183215727212 -0.765065237103568 0.470562943017242 0.929276781658587 -0.45410731591959 "MYC MUT" "Doxorubicin_IC_50" 0.2646905141911 0.726651145759245 0.344596687614321 0.13932667496867 0.762183215727212 0.286697204901008 0.978710866945745 0.997696419805459 0.00830201519969137 "AKT2 MUT" "JNJ.26854165_IC_50" 0.240144386628943 0.711340033600749 -0.549558552036202 0.139372248689575 0.762183215727212 -0.644772741221272 0.143910425404407 0.831473272394224 -0.652775149644396 "PIK3CA MUT" "KU.55933_IC_50" 0.0613994482419082 0.447125180000976 0.349061050108929 0.139415244535958 0.762183215727212 0.248552008035271 0.210656203311328 0.855272470862467 0.254675774398637 "MLH1 MUT" "AZD7762_IC_50" 0.25116738945431 0.717470497840808 0.624579124559547 0.139444690051616 0.762183215727212 0.63579928887772 0.0104611481643771 0.450367315182713 1.2757307211901 "ALK MUT" "Shikonin_IC_50" 0.336075843846087 0.773636487609408 -1.39328478620689 0.13950929235233 0.762183215727212 -1.80142282677661 0.424799039537948 0.922428741067589 -1.58907104006718 "MYCL1 MUT" "GSK269962A_IC_50" 0.0470548718015502 0.384922051833884 1.88711697594503 0.13975990495951 0.762183215727212 1.32898924171974 0.300962822137912 0.894167310052 1.02126298402955 "TP53 MUT" "AZ628_IC_50" 0.000973739961439842 0.0445762092657074 1.07591763987122 0.139813753655459 0.762183215727212 0.383138418776207 0.16027242673678 0.838901067822678 0.434713171297236 "EP300 MUT" "Metformin_IC_50" 0.381226985969358 0.797756093872259 0.729868380952387 0.139814029861992 0.762183215727212 1.15221777977799 0.566829459091889 0.949294892873838 0.465477592195643 "MLH1 MUT" "Imatinib_IC_50" 0.0709147449716614 0.471755692953802 0.897767345360828 0.139996657922008 0.762183215727212 0.732521798103852 0.043943678345471 0.659657620288543 1.07126852958888 "JAK2 MUT" "AG.014699_IC_50" 0.122815913841803 0.581721669775496 0.844182882086176 0.14000437293497 0.762183215727212 0.715743754662979 0.798614601838943 0.976360691959787 0.140950247610609 "CDK4 MUT" "PF.4708671_IC_50" 0.34744819719072 0.782573532653 -0.352893356164382 0.140017288851944 0.762183215727212 -0.54756991821916 0.150486678811151 0.831473272394224 -0.573542343029795 "SETD2 MUT" "BMS.536924_IC_50" 0.302150639540753 0.752409982102741 -1.8079671118644 0.14003191966863 0.762183215727212 -1.95117217077508 0.82322354102683 0.978066657907595 -0.375331662021456 "CTNNB1 MUT" "EHT.1864_IC_50" 0.223124858618071 0.696139064632428 -0.450503652968032 0.140070711139484 0.762183215727212 -0.544222165130515 0.797632809689669 0.976360691959787 -0.10226613953055 "MET MUT" "JNK.9L_IC_50" 0.573685625045956 0.872620551543038 0.23520367919121 0.140108271908573 0.762183215727212 0.483262561442238 0.715988769757815 0.963292874446168 0.150695117299739 "CDK4 MUT" "KIN001.135_IC_50" 0.0857451651755525 0.504306497962968 -0.945084006734001 0.140144974217263 0.762183215727212 -0.800831555118322 0.126796481763581 0.817150972850516 -0.792280176087594 "NRAS MUT" "X681640_IC_50" 0.00335771640313893 0.094069020114438 -0.88351179491102 0.140168676869388 0.762183215727212 -0.393664648538296 0.0314092138610935 0.614416802423725 -0.699976582509837 "ALK MUT" "Pazopanib_IC_50" 0.149017806160645 0.624258083260701 1.92420730956523 0.140407495442568 0.762183215727212 1.6741427476869 0.162640218274546 0.839927262232576 2.39548911063419 "MYC MUT" "Cyclopamine_IC_50" 0.0672209392551616 0.460513103960953 0.564106498141262 0.140427254216694 0.762183215727212 0.425753069600412 0.348597973410371 0.909999728614578 0.306674849550346 "PDGFRA MUT" "Midostaurin_IC_50" 0.0521527892681659 0.407137850996674 -1.62705332582321 0.1404601492457 0.762183215727212 -0.9493929658287 0.416452868229951 0.922398153848459 -0.629490574946763 "FLCN MUT" "BIRB.0796_IC_50" 0.228386985121418 0.700676460618178 -0.734626625239003 0.140476189108449 0.762183215727212 -0.860474009958447 0.350419398984006 0.910340341961272 -0.794119829794908 "SMARCA4 MUT" "Mitomycin.C_IC_50" 0.0945547436573311 0.526813474542508 1.12647188901382 0.140499584709934 0.762183215727212 0.772220350081622 0.298213206488083 0.894167310052 0.76635300903119 "CDKN2a(p14) MUT" "Bleomycin_IC_50" 0.00120718770997596 0.0505709153410212 -0.92252425107716 0.140605121060932 0.762183215727212 -0.359974646192324 0.122003487954351 0.809590452621284 -0.475440139762045 "CCND1 MUT" "Doxorubicin_IC_50" 0.0908637287538092 0.516289683341382 0.649134727878784 0.140628331868586 0.762183215727212 0.355021254331174 0.216652214073703 0.860576337437605 0.484426907611506 "KRAS MUT" "Bosutinib_IC_50" 0.00198201463698466 0.0662499796990626 0.652285984443395 0.140681094241879 0.762183215727212 0.271136386417532 0.0167537758678921 0.513211661128791 0.543391044935737 "MYC MUT" "Bexarotene_IC_50" 0.541211261554823 0.861616652986104 -0.155541179601081 0.140946110425192 0.762183215727212 -0.336154701116318 0.0620753077641817 0.702860976445846 -0.478951301055924 "PIK3CA MUT" "A.770041_IC_50" 0.378412923384812 0.795952477739693 0.638443526273022 0.140971624377331 0.762183215727212 0.869950841687448 0.502012699580311 0.934042323734638 0.506871942221516 "MSH2 MUT" "PF.02341066_IC_50" 0.257646808491935 0.721889937062894 -0.829454437288134 0.140992531935549 0.762183215727212 -0.999587122928382 0.490357546209135 0.933639405738697 -0.502536789998886 "RUNX1 MUT" "GDC.0449_IC_50" 0.17991966553392 0.658614416960816 -0.94798800128949 0.141070072928918 0.762183215727212 -0.923435877593543 0.134788484442951 0.828635349589072 -1.03901902020135 "MAP2K4 MUT" "Gefitinib_IC_50" 0.118732855659954 0.577025305814989 0.738842558349459 0.141078461299557 0.762183215727212 0.627581003030029 0.0459276455333274 0.672064548802462 0.94193024939027 "TP53 MUT" "Lapatinib_IC_50" 0.261653595337094 0.724288808298587 -0.245169844169246 0.141161142829628 0.762183215727212 -0.29074223199882 0.737833934891237 0.96672489654949 -0.069993461323628 "KDM6A MUT" "SL.0101.1_IC_50" 0.00518981603789207 0.123814276771508 -0.812867095709572 0.141181542522301 0.762183215727212 -0.378162824110123 0.00907965569883216 0.424402222428044 -0.752050299947312 "MLL_AFF1 MUT" "QS11_IC_50" 0.561064955780646 0.870276331255523 -0.80734773391305 0.141192280074306 0.762183215727212 1.52679696174262 0.980601111399214 0.997827228172038 -0.0331814441585633 "MYCN MUT" "AZD.0530_IC_50" 0.983136349936642 0.996723172778267 0.00967225265501882 0.141209544563826 0.762183215727212 -0.605854049505373 0.0179444891758013 0.513211661128791 -1.2216203174742 "TP53 MUT" "NVP.BEZ235_IC_50" 0.966755841118178 0.994434372972651 0.0060926440629776 0.141262647572007 0.762183215727212 -0.163367144949021 0.482099380513602 0.931171074019421 -0.104720940778734 "CDK4 MUT" "BIBW2992_IC_50" 0.0776572796503132 0.486980385654137 1.06680598265896 0.14140319692958 0.762230158543535 0.852979662295539 0.314883731218331 0.900294798053993 0.588977269545146 "CCND3 MUT" "Cisplatin_IC_50" 0.238419456199752 0.710855542080976 1.3840578235294 0.141443002058298 0.762230158543535 1.49526491402953 0.198991946378134 0.851001889249827 1.43695706432209 "TSC1 MUT" "AZD6482_IC_50" 0.0779519271142449 0.486980385654137 2.45182491896555 0.14163094452624 0.76234335084464 1.72638003838704 0.0763735975450949 0.741811190933953 2.40047156836041 "MYCN MUT" "ABT.888_IC_50" 0.629963432306967 0.892582202029064 0.12214928705523 0.141635686172014 0.76234335084464 0.322938056200684 0.175180621810581 0.846738869764556 0.377516663119589 "RUNX1 MUT" "NSC.87877_IC_50" 0.177629072307489 0.656513564381252 -0.677292790294622 0.14208031852427 0.76305927166004 -0.722461986450817 0.0287404033918467 0.597512888074595 -1.2369997837554 "SMAD4 MUT" "Shikonin_IC_50" 0.160923791503293 0.636336191287136 0.545883733117171 0.14210466048063 0.76305927166004 0.494826001488578 0.360527030671698 0.91161229252998 0.373259759500351 "KRAS MUT" "AMG.706_IC_50" 0.0103031327239373 0.180477557635674 0.393091776759007 0.142111764185247 0.76305927166004 0.220300002071978 0.252639763676465 0.875707386589409 0.189509831458016 "VHL MUT" "Cyclopamine_IC_50" 0.170441380852513 0.649721929411943 -1.01858706896553 0.142112378710247 0.76305927166004 -1.01290227184912 0.126351688888997 0.817150972850516 -1.1922717223932 "RB1 MUT" "X17.AAG_IC_50" 0.915692821440634 0.98476490303336 0.0328434923794366 0.142269295792851 0.763241201236537 -0.409264623161527 0.0136314070459716 0.482141194305023 -0.743091364894573 "FBXW7 MUT" "PHA.665752_IC_50" 0.130781299645903 0.59349449267004 -0.664729896551729 0.142539627642929 0.763241201236537 -0.654236404442832 0.0851858783781502 0.749680540483183 -0.80102345993524 "MYCN MUT" "Parthenolide_IC_50" 0.559079304541953 0.869406987154103 -0.21073726961288 0.14261875555056 0.763241201236537 -0.503994918534546 0.407413352353564 0.919870246008857 -0.363510030312984 "GNAS MUT" "IPA.3_IC_50" 0.0357487314707815 0.347105523744792 1.38004163315696 0.142626463305815 0.763241201236537 0.80968366357934 0.15881683532263 0.83854630828105 0.868104834784603 "BCR_ABL MUT" "PLX4720_IC_50" 0.026723613064984 0.30299183543909 -2.09714920729364 0.142649656687552 0.763241201236537 1.50804676104264 0.153926855735377 0.835611501078903 -1.26549403223906 "MS-HL MUT" "BMS.754807_IC_50" 0.748127448344876 0.932115582035752 0.094841808370422 0.14281217206513 0.763241201236537 0.364179986661747 0.557152299118159 0.949136321936116 0.189415050073502 "BRAF MUT" "PAC.1_IC_50" 0.162261489686227 0.637610023074489 -0.341685947056773 0.142910036761011 0.763241201236537 -0.329460675464703 0.0755510118654915 0.741811190933953 -0.500949873480323 "MLL_AFF1 MUT" "JNK.Inhibitor.VIII_IC_50" 0.0132779462663474 0.207974322383477 -1.99847106666672 0.142925824734892 0.763241201236537 -1.14943509785872 0.0664622508520559 0.713091135801027 -1.51246896827914 "FGFR2 MUT" "Obatoclax.Mesylate_IC_50" 0.0595063816728728 0.439862785571841 2.17433009816756 0.142990829495149 0.763241201236537 -1.26584733998484 0.164334655825332 0.839927262232576 1.77559154714498 "AKT2 MUT" "PHA.665752_IC_50" 0.227183351622257 0.699346740297147 1.17270580536912 0.143005670403963 0.763241201236537 1.39942852400116 0.150788938966723 0.831473272394224 1.43318442525365 "CDK6 MUT" "GSK269962A_IC_50" 0.471196468644259 0.832609597697904 -0.966196156462583 0.143172660110385 0.763434944524814 -1.82355786080255 0.859834266402186 0.985479880500142 -0.288675936358322 "VHL MUT" "RO.3306_IC_50" 0.199348932723984 0.674012093366938 -0.671653873517776 0.143213896810983 0.763434944524814 -0.733948721040296 0.733392002952526 0.96672489654949 -0.193355542592474 "BCR_ABL MUT" "Mitomycin.C_IC_50" 0.76898189896994 0.938868331695358 -0.326548213787093 0.143554879868788 0.763703971151359 -1.53484470042251 0.326011606993989 0.901123274731908 1.08209549651099 "VHL MUT" "Salubrinal_IC_50" 0.576632064496385 0.873455460479685 -0.483313659793816 0.143666405210751 0.763703971151359 -1.05272677846482 0.472945479362435 0.929276781658587 -0.646833255098726 "BCR_ABL MUT" "Bortezomib_IC_50" 0.94871876391156 0.991243687329243 0.0729030993150687 0.143671145092595 0.763703971151359 1.70223018276813 0.991965650279304 0.999392732856551 0.011047803269493 "SMARCA4 MUT" "Doxorubicin_IC_50" 0.742491741335593 0.929570057037101 -0.195035885480245 0.143677220334119 0.763703971151359 -0.53693427941758 0.819050691769284 0.977383317127464 -0.145279429843173 "MET MUT" "KU.55933_IC_50" 0.0369147751999632 0.351006550910999 0.796667287331153 0.143694328993798 0.763703971151359 0.498341856984564 0.101412509185597 0.774414870229822 0.614819948718976 "KRAS MUT" "AZD.0530_IC_50" 0.292974081392555 0.747036827777118 0.461053445652172 0.143821760881773 0.763924077985063 0.584708988522199 0.0784253364101507 0.741811190933953 0.793244676463735 "PIK3CA MUT" "Nutlin.3a_IC_50" 0.581919301965638 0.876233523356533 0.15428018933509 0.144048438683727 0.764670761476495 -0.379950000893059 0.918163944601578 0.992963223576061 0.0307581038728644 "MSH2 MUT" "NSC.87877_IC_50" 0.376080330821355 0.795051761241315 0.352643205574913 0.144267075024562 0.764992206009615 0.574860145841218 0.520055726049374 0.939635632721979 0.262257511051955 "NRAS MUT" "Dasatinib_IC_50" 0.619820653869076 0.887556792488111 0.439063264069267 0.144387667005589 0.764992206009615 1.10305941957198 0.890186716748439 0.988301482344111 0.119531403162639 "BRAF MUT" "Lenalidomide_IC_50" 0.363106950496172 0.787293170741334 -0.137470040276181 0.144450755968549 0.764992206009615 -0.212495781322499 0.0729468729843707 0.739487156743738 -0.309619049814919 "ERBB2 MUT" "AZD6244_IC_50" 0.0506741633580804 0.401102713710439 1.07878567809763 0.14445354458711 0.764992206009615 0.757499921044113 0.184037311542243 0.851001889249827 0.700911387651446 "NF2 MUT" "Bleomycin_IC_50" 0.0535477120289352 0.413543213551623 -1.41315190964373 0.144601316534839 0.765318410098871 -0.875169968756144 0.531180717797308 0.94320946427311 -0.476862142874073 "EGFR MUT" "AKT.inhibitor.VIII_IC_50" 0.348734520112287 0.784277354549816 0.319140202768921 0.144700031900395 0.76537857444231 0.428222896983125 0.0758494608833125 0.741811190933953 0.619506000249155 "MSH6 MUT" "DMOG_IC_50" 0.380966321516821 0.797708787892259 0.558100391986061 0.144785047299075 0.76537857444231 0.833703030391696 0.390443978441996 0.915926348152589 0.512885855385016 "CDH1 MUT" "AZD7762_IC_50" 0.00603181314276067 0.135468169248153 1.7423743468208 0.145129834819005 0.766244676271909 0.733333949420852 0.0695660589370445 0.724286247854505 1.12885962230827 "KRAS MUT" "GSK.650394_IC_50" 0.0314428709747381 0.328181974777787 -0.532765079182059 0.145325784096895 0.766244676271909 -0.246954263345716 0.0426532172195113 0.658180729724545 -0.571650181684772 "MS-HL MUT" "AZD.2281_IC_50" 0.864786291775461 0.967489995749939 -0.0353008570408512 0.145336520305771 0.766244676271909 0.22756775303628 0.644364192932022 0.956479997081018 0.0920867471100402 "RB1 MUT" "Pazopanib_IC_50" 0.953741256762173 0.992679871625456 -0.0142968149795412 0.145543042302784 0.766244676271909 -0.313116824821159 0.722276152968515 0.965402608571648 -0.0908011300812722 "CDK6 MUT" "Bleomycin_IC_50" 0.689716456970511 0.912464152294818 -0.468789492530758 0.145589139029416 0.766244676271909 -1.39227087536504 0.923255257455536 0.993931766508607 -0.116557493098906 "MLL_AFF1 MUT" "Bortezomib_IC_50" 0.13815977964887 0.606087209949663 2.36426770408164 0.145639966421278 0.766244676271909 1.92692323856193 0.27358717430153 0.882167181782537 1.66887623163255 "PIK3CA MUT" "BMS.708163_IC_50" 0.227643914153254 0.699759797702227 0.22768808964701 0.14582949363556 0.766244676271909 0.279623659686817 0.372532305565599 0.913948248824328 0.186304723530855 "MS-HL MUT" "Etoposide_IC_50" 0.133562045280293 0.600164731037035 -0.467779293917414 0.145948932225002 0.766244676271909 0.298380216885716 0.0972444996739294 0.772625185318248 -0.544677989002227 "FGFR2 MUT" "Etoposide_IC_50" 0.000132647564128453 0.0117804301702479 4.6666463771626 0.145951663521774 0.766244676271909 1.17790359035276 0.00257692849279028 0.272034735859731 4.02737021239138 "KRAS MUT" "Vinorelbine_IC_50" 0.445708535929495 0.825858023699112 0.183926746829267 0.145976183554562 0.766244676271909 0.27138881114393 0.653467479592673 0.958313128388245 0.121896492667559 "BRAF MUT" "BI.D1870_IC_50" 0.597612643622509 0.879232253518807 0.121014810285052 0.146075016876408 0.766244676271909 0.315892891225063 0.891630433065107 0.988301482344111 -0.035341454395743 "BRCA2 MUT" "Gemcitabine_IC_50" 0.740667076110792 0.929570057037101 -0.550451416228839 0.146076530607696 0.766244676271909 -1.62048854652618 0.225505060810275 0.86643108387559 -1.90511708058032 "CDKN2C MUT" "QS11_IC_50" 0.034507784573955 0.342986337003385 1.32004848853615 0.146176391367256 0.766244676271909 0.670161966488053 0.118658379801796 0.806524749270063 1.13568978907553 "TET2 MUT" "Doxorubicin_IC_50" 0.739027770243173 0.929570057037101 -0.37602915156794 0.146233205707809 0.766244676271909 1.03095575146976 0.780602819769644 0.972714135312783 0.366742936987204 "SMARCA4 MUT" "Cytarabine_IC_50" 0.312407706921905 0.759215564942334 -0.639557194605011 0.146321492380458 0.766244676271909 -0.691914499399172 0.776492146578299 0.972337708041191 -0.189888705596853 "TP53 MUT" "Pazopanib_IC_50" 0.0783171076290541 0.486980385654137 0.291564872828565 0.146329351532165 0.766244676271909 0.212691353465394 0.532723608325241 0.943443271455699 0.101984699019793 "SMAD4 MUT" "SL.0101.1_IC_50" 0.103927305640601 0.546464417640129 0.397629190527778 0.146561639087904 0.767008790064627 0.3176287165968 0.349716143875865 0.909999728614578 0.234373915588491 "FLT3 MUT" "Bexarotene_IC_50" 0.103487012208868 0.545441041796411 -1.31064778534034 0.146663245162133 0.767029877662957 -1.05237324228276 0.0812726369529035 0.741811190933953 -1.34912542637363 "CTNNB1 MUT" "CEP.701_IC_50" 0.145515771734475 0.619919550890177 -0.754025390578406 0.146738403574976 0.767029877662957 -0.553291317654998 0.0331480784657031 0.618827479917328 -1.09153908214264 "BCR_ABL MUT" "Cyclopamine_IC_50" 0.293852658765514 0.747036827777118 -0.780523103448287 0.146834480691104 0.767080601775116 1.25391744939603 0.909878400096538 0.99003063847799 -0.0859264289824602 "NF1 MUT" "NVP.BEZ235_IC_50" 0.162120509488321 0.637610023074489 0.469841571240358 0.146967639586565 0.767092733878594 0.354464855077936 0.593750654334786 0.949294892873838 0.185238281932552 "BCR_ABL MUT" "MK.2206_IC_50" 0.0721316417003784 0.474889173046706 -1.60931553778465 0.147071759490288 0.767092733878594 -1.27981340312438 0.570355092819706 0.949294892873838 -0.512169446259719 "NOTCH1 MUT" "GNF.2_IC_50" 0.147809366955452 0.621176831431336 0.556586187240825 0.147136551067708 0.767092733878594 0.555619173809129 0.493326667342178 0.933639405738697 0.309350566922391 "PTEN MUT" "AZD.0530_IC_50" 0.443804518711444 0.825606373270691 0.245900046183722 0.147182301376999 0.767092733878594 0.409133302934233 0.122079463672344 0.809590452621284 0.503736084488471 "GNAS MUT" "Z.LLNle.CHO_IC_50" 0.356375730791336 0.786601117838604 0.97097822411831 0.14731365149112 0.767119875133688 1.40389390022714 0.175727907202634 0.847235321998113 1.39457587261037 "BRCA1 MUT" "BAY.61.3606_IC_50" 0.0831729469813187 0.498552626562699 1.65960934380457 0.147360264269572 0.767119875133688 0.966170258319832 0.152011758630166 0.832065593775825 1.29840052591807 "FBXW7 MUT" "GSK269962A_IC_50" 0.21435351663893 0.688117861819268 -0.880845664335671 0.147638912140508 0.767194644005234 -0.981048030844427 0.0599757007624305 0.70215997387469 -1.37981168714221 "CTNNB1 MUT" "Bleomycin_IC_50" 0.0163410924058855 0.233354840019847 -2.06681731435352 0.147854754314333 0.767194644005234 -1.01678045505763 0.125204282105759 0.817150972850516 -1.43042238567638 "CTNNB1 MUT" "AZ628_IC_50" 0.0849253045139198 0.5031498528273 -1.91249020114944 0.147895078612365 0.767194644005234 -1.18877277634646 0.0961537447033533 0.77097828178369 -1.77534891903838 "CDH1 MUT" "Bicalutamide_IC_50" 0.123696763307052 0.583699714338599 -0.320505356025041 0.14796872479326 0.767194644005234 -0.29091045343899 0.151202492390122 0.831473272394224 -0.29985621961166 "NOTCH1 MUT" "NU.7441_IC_50" 0.564683890921765 0.871775968539349 0.263113274549097 0.148046369758263 0.767194644005234 0.598718873651742 0.310443871498056 0.89718581932126 0.480420159122298 "SMAD4 MUT" "LFM.A13_IC_50" 0.184287926037527 0.660385845878234 -0.279578234331741 0.148145966284441 0.767194644005234 -0.295619497568485 0.273179672233165 0.882167181782537 -0.246766407199101 "MYCL1 MUT" "MS.275_IC_50" 0.327610320933269 0.769735904120651 -0.885042980392161 0.148381998985048 0.767194644005234 -1.09757973056856 0.24769498390554 0.875707386589409 -1.13021643856507 "MSH2 MUT" "Bleomycin_IC_50" 0.0382398393991641 0.354296016737578 -2.59432792481206 0.148435610122045 0.767194644005234 -1.48715523121976 0.0688530590963267 0.722654662887059 -2.21629235534634 "AKT2 MUT" "AZD6244_IC_50" 0.10719239213578 0.551794991672845 1.62023685477177 0.148492632167516 0.767194644005234 1.3177238241774 0.284277455669644 0.8879937007725 0.972608275584676 "SMARCA4 MUT" "AMG.706_IC_50" 0.419481085273472 0.814360928614146 -0.330514742063493 0.148529210554712 0.767194644005234 -0.541382085461033 0.560362721436765 0.949294892873838 -0.250833399043469 "STK11 MUT" "TW.37_IC_50" 0.4150420793081 0.814043442211845 -0.226288527470451 0.148588068472916 0.767194644005234 -0.361100852708962 0.147062165690364 0.831473272394224 -0.409303232019818 "PIK3R1 MUT" "Bosutinib_IC_50" 0.0349511357059068 0.345273677646449 1.3474986628131 0.148610620012119 0.767194644005234 0.75745922559476 0.122154172560806 0.809590452621284 0.911534838162875 "MSH2 MUT" "Elesclomol_IC_50" 0.198205007912201 0.674012093366938 1.06555239819376 0.149024046924419 0.767194644005234 0.993595259919975 0.461466260868231 0.929276781658587 0.580455355303837 "GNAS MUT" "BAY.61.3606_IC_50" 0.0187869763962083 0.24981411768757 1.4294684021164 0.149065056573095 0.767194644005234 0.610992839214898 0.110384746150816 0.797376436030023 0.920069813277669 "CDKN2a(p14) MUT" "RDEA119_IC_50" 0.00323489377535163 0.0914939223531777 -0.62728151554404 0.14906512623107 0.767194644005234 -0.289457136017433 0.838312825378622 0.981704379975756 0.0419078850281888 "BRAF MUT" "AZD6482_IC_50" 0.850476759205423 0.963526482778845 -0.052524828186993 0.149081241620391 0.767194644005234 -0.373735529050999 0.479728734682564 0.930304161706959 -0.230030894775646 "MAP2K4 MUT" "Etoposide_IC_50" 0.60532366000971 0.882603260686518 -0.354983281330266 0.149137193453207 0.767194644005234 -0.645115982810373 0.655996495141562 0.958313128388245 -0.318621972320445 "MYCL1 MUT" "CHIR.99021_IC_50" 0.0788900168934717 0.487898495843261 0.803128059440553 0.149223715051143 0.767194644005234 0.62489616899911 0.659065168431321 0.958313128388245 0.212816658927264 "BRCA1 MUT" "PF.562271_IC_50" 0.114626193465332 0.567167686753817 1.08643368977468 0.149290583073831 0.767194644005234 0.810267032031395 0.156980139737616 0.837288218996252 0.959586336713805 "FBXW7 MUT" "AZD.2281_IC_50" 0.934224822612529 0.987517726433927 0.0269353306631888 0.149387321321612 0.767194644005234 0.356277925343949 0.200306580979643 0.851001889249827 0.391389944416873 "MS-HL MUT" "PAC.1_IC_50" 0.00658792851146892 0.140825544793469 -0.599786067956186 0.149447380324309 0.767194644005234 -0.26879080229757 0.168444354579884 0.84067330207935 -0.327277489048857 "ALK MUT" "Camptothecin_IC_50" 0.0403067196124034 0.362678801294585 -3.25795396015179 0.149547402889013 0.767194644005234 -1.44739772384097 0.058020441789749 0.70215997387469 -2.67418628772559 "EWS_FLI1 MUT" "Parthenolide_IC_50" 0.15526011904432 0.630721638230745 0.694946458333337 0.149681504948678 0.767194644005234 0.70564993665781 0.234398205386184 0.869962136993019 0.686565892661671 "MSH6 MUT" "Docetaxel_IC_50" 0.388791929124766 0.800307511703073 0.639396461737992 0.149683325458063 0.767194644005234 0.802816940375472 0.430437386769816 0.922428741067589 0.560046825046459 "ALK MUT" "NVP.BEZ235_IC_50" 0.838427405907464 0.959212868273494 0.182207555776893 0.149825317812586 0.767194644005234 0.931650667320255 0.397555803406318 0.916480913435499 -0.882901492967431 "RB1 MUT" "ZM.447439_IC_50" 0.139532996155785 0.608939822535396 -0.33933041392915 0.150034888849271 0.767194644005234 -0.268443911901232 0.279892246741422 0.88601917827756 -0.260112176585922 "MAP2K4 MUT" "GNF.2_IC_50" 0.441898137566471 0.825166478070376 0.559206235494881 0.150041397238945 0.767194644005234 0.997767629612466 0.412963035636461 0.921714070263062 0.737177317745855 "MET MUT" "BI.2536_IC_50" 0.913347674144226 0.983681869279028 -0.175108027118645 0.150169733975012 0.767194644005234 -1.36558117688333 0.953665759938382 0.99568364368633 0.096975940343361 "KIT MUT" "AZD6244_IC_50" 0.312113577082326 0.759215564942334 1.13637061904762 0.150372498478477 0.767194644005234 1.47020717297103 0.354096820460381 0.911252930312559 0.939501468042231 "KDM5C MUT" "Shikonin_IC_50" 0.367652385505821 0.789246419666677 -0.924296922145339 0.150592490903934 0.767194644005234 -1.24226200806133 0.420488248336225 0.922428741067589 -0.803675081280522 "NF2 MUT" "OSI.906_IC_50" 0.238772556090011 0.710855542080976 0.533475395169584 0.150612417961766 0.767194644005234 0.620610207419618 0.169986984127447 0.84067330207935 0.672735160368423 "GNAS MUT" "CCT007093_IC_50" 0.232183227272411 0.704757001699372 0.406739909297052 0.150677175201851 0.767194644005234 0.488812228388758 0.194126774810727 0.851001889249827 0.448771646666919 "CDKN2C MUT" "VX.680_IC_50" 0.221212662552942 0.693711036770013 1.3248804678161 0.150876393488744 0.767194644005234 1.01399102933635 0.432850520521165 0.922569292988365 1.06626675185161 "MYCN MUT" "Cyclopamine_IC_50" 0.0327475609127711 0.333904808801746 0.712034432234432 0.151180886039041 0.767194644005234 0.454344494412183 0.356459884648731 0.91161229252998 0.367967299304007 "EWS_FLI1 MUT" "AZD.0530_IC_50" 0.169265372238611 0.648365181185948 0.852507017361115 0.151201323614982 0.767194644005234 0.846878216003006 0.298541336389058 0.894167310052 0.696522250735367 "FGFR3 MUT" "Etoposide_IC_50" 0.973229472760235 0.995472410100622 0.0475767806563024 0.151223923464821 0.767194644005234 1.32136381533093 0.925748423438078 0.994026707431102 0.124779134658353 "CTNNB1 MUT" "BAY.61.3606_IC_50" 0.127749853715752 0.588664235316545 -0.760936799525513 0.151288739254588 0.767194644005234 -0.498842617826292 0.274869875560403 0.883780956691668 -0.57572295057018 "CDH1 MUT" "RO.3306_IC_50" 0.076358969596503 0.483683312058227 0.926787084980226 0.151296912971262 0.767194644005234 0.725112202038502 0.410786845590627 0.921714070263062 0.462570463368968 "BRAF MUT" "AKT.inhibitor.VIII_IC_50" 0.110464974304382 0.559686423710509 0.361786761600827 0.151311121710398 0.767194644005234 0.300451875168973 0.919814746151315 0.993794649720217 0.0266975779851385 "PIK3CA MUT" "Sorafenib_IC_50" 0.059461367213618 0.439862785571841 0.986105854008666 0.151338517330475 0.767194644005234 0.714785482537025 0.0335102749910118 0.618827479917328 1.25585113621795 "TET2 MUT" "NSC.87877_IC_50" 0.446290440260258 0.825892730562573 -0.493397409326412 0.151493089668455 0.767194644005234 -0.924328376824541 0.669558404432556 0.959230524020512 -0.343892406971286 "MDM2 MUT" "AG.014699_IC_50" 0.835323610938862 0.959122768755193 -0.0956014360730585 0.151545047949987 0.767194644005234 -0.57928112646581 0.947705317096408 0.995668765770473 -0.027831122577048 "CDH1 MUT" "ABT.263_IC_50" 0.143799582927026 0.617247025604118 1.13205921146244 0.151561873414253 0.767194644005234 1.01351288626332 0.135975233459591 0.829962919831358 1.0769382381351 "CTNNB1 MUT" "AMG.706_IC_50" 0.171633905143387 0.649721929411943 0.511585810092965 0.151642917844494 0.767194644005234 0.494826887742509 0.408590838743337 0.920903133902018 0.31278141346844 "MAP2K4 MUT" "EHT.1864_IC_50" 0.161000723096745 0.636336191287136 0.566372500000003 0.15168399929707 0.767194644005234 0.572760378940289 0.0904638777051765 0.764118629741502 0.705830413404534 "EP300 MUT" "BX.795_IC_50" 0.191426762027558 0.666952166954391 -1.2075452521974 0.151713005861625 0.767194644005234 -1.02416185714024 0.160282831469466 0.838901067822678 -1.13585031554625 "CDKN2a(p14) MUT" "ATRA_IC_50" 0.143227019064085 0.61606176606809 0.226585723312883 0.151731991434575 0.767194644005234 0.181338892556858 0.366423951942636 0.913948248824328 0.136865343501803 "PDGFRA MUT" "ATRA_IC_50" 0.130931422492044 0.593872299873259 1.16955812859886 0.151817222601746 0.767194644005234 0.873969187106073 0.18505556087661 0.851001889249827 0.913601981043356 "TET2 MUT" "Salubrinal_IC_50" 0.0517929755472861 0.405681287963057 -1.93497968036527 0.152028635731343 0.767194644005234 -1.18807042238375 0.0954784844526408 0.77097828178369 -2.01005213838807 "EP300 MUT" "ABT.888_IC_50" 0.505158516457567 0.847679261741881 -0.407850077608152 0.152041315466002 0.767194644005234 -0.74218521152706 0.336044140779853 0.905430766021494 -0.547461180822845 "HRAS MUT" "Vinorelbine_IC_50" 0.136542021308566 0.604186327814048 1.35269937088387 0.152083647990898 0.767194644005234 0.958093529566225 0.056476937439884 0.697813103075383 1.70302057339809 "KDM6A MUT" "CMK_IC_50" 0.0398147267731888 0.361141839503332 -0.899251182142851 0.152223323529086 0.767194644005234 -0.577014691706665 0.0148425452507704 0.490024700267999 -1.18536176897091 "SMO MUT" "BMS.708163_IC_50" 0.201489876771859 0.674012093366938 1.09774871205357 0.152238870091571 0.767194644005234 1.2351173231057 0.238399951695309 0.875707386589409 1.02062357216671 "RB1 MUT" "GDC0941_IC_50" 0.644129740587313 0.896446680008675 -0.131240165915917 0.152241858440841 0.767194644005234 -0.333895227233642 0.662085125715388 0.958689538788368 -0.137099735896917 "MS-HL MUT" "ABT.888_IC_50" 0.0457199800335154 0.381974734409831 -0.283087375547345 0.152344256794082 0.767194644005234 -0.17170303192158 0.306969503988792 0.896682870760742 -0.148249116149736 "MAP2K4 MUT" "RDEA119_IC_50" 0.230896067382776 0.703702118883469 -0.818151818686861 0.152386153796698 0.767194644005234 -0.883175328139517 0.977797198676457 0.99756656191219 -0.0180190898796753 "BRAF MUT" "JNK.Inhibitor.VIII_IC_50" 0.458378308903588 0.828966839128293 0.120677711864405 0.152577639604789 0.767194644005234 0.235884154382287 0.738723240633945 0.96672489654949 0.0652342828738502 "MAP2K4 MUT" "Tipifarnib_IC_50" 0.132735649384691 0.59918542084564 -0.943240721767581 0.152660879148668 0.767194644005234 -0.596609033740552 0.179865914806914 0.848722027112292 -0.910515985013949 "MYCL1 MUT" "AZ628_IC_50" 0.0247490299887535 0.290735628743544 2.4881334632184 0.152682900853389 0.767194644005234 1.19819175777796 0.571855703452704 0.949294892873838 0.565715890170426 "MLL_AFF1 MUT" "PF.562271_IC_50" 0.0416059075801368 0.368149973799425 -2.21098883275862 0.152843542396497 0.767194644005234 -1.29027962430427 0.0367947309016893 0.639479462109399 -2.23817633957976 "BRCA2 MUT" "Bleomycin_IC_50" 0.5444612040948 0.862633715268747 -0.82024295096323 0.152926220889342 0.767194644005234 -1.57968686832128 0.337051470832908 0.905430766021494 -1.26373390345741 "VHL MUT" "Parthenolide_IC_50" 0.19965058841834 0.674012093366938 -1.02792159322034 0.153040855430583 0.767194644005234 -1.07986877047693 0.199833970906567 0.851001889249827 -1.1067209296074 "TSC1 MUT" "Midostaurin_IC_50" 0.90248397091138 0.979694707150557 -0.162162463793106 0.153056829381872 0.767194644005234 -1.45814172353059 0.906303065875836 0.988917021334873 -0.141246657468985 "CTNNB1 MUT" "CMK_IC_50" 0.426654654595537 0.81941696345643 0.559692312643682 0.153191501690108 0.767194644005234 0.911950838377666 0.83837907641523 0.981704379975756 0.163543989945657 "MSH2 MUT" "AZD8055_IC_50" 0.0417108939040781 0.368225098173079 -1.0980046897143 0.153196299452404 0.767194644005234 -0.600354699576766 0.0565617290593756 0.697813103075383 -1.00244255910309 "MDM2 MUT" "KIN001.135_IC_50" 0.0546830400516905 0.417934663252206 -0.671359115646259 0.153227121345161 0.767194644005234 -0.488896437883529 0.0737670628171745 0.741621865836141 -0.586812235565327 "GNAS MUT" "GW.441756_IC_50" 0.138554604242535 0.606920362078576 -0.641206262476003 0.153232408651586 0.767194644005234 -0.60420937740201 0.14092897521231 0.831473272394224 -0.631195011905695 "PDGFRA MUT" "CCT007093_IC_50" 0.121931272100381 0.580982694522287 -0.702895955056181 0.153274585476772 0.767194644005234 -0.65076816769675 0.152208799728926 0.832065593775825 -0.668566918442019 "BRCA1 MUT" "AZD.0530_IC_50" 0.157804338572935 0.633503899390536 -2.02292237037035 0.153421825401247 0.767194644005234 -1.76380471432775 0.112245227588696 0.797376436030023 -2.16815295991737 "BRCA2 MUT" "WO2009093972_IC_50" 0.0267476183970551 0.30299183543909 1.5316557679814 0.153478037058222 0.767194644005234 0.897612206762828 0.171104779191765 0.842832361237713 0.945903091411562 "RUNX1 MUT" "Methotrexate_IC_50" 0.181015778638985 0.658636992153339 -1.71460073293172 0.15351325479816 0.767194644005234 -1.38909617957455 0.0348249804421156 0.621045484551062 -2.12244163942925 "EWS_FLI1 MUT" "PD.173074_IC_50" 0.989716620262773 0.998036562927507 -0.00503128571428561 0.153632930953207 0.767194644005234 0.508834378526695 0.0492925378083043 0.679896345274018 0.817982884180458 "MLLT3 MUT" "Gefitinib_IC_50" 0.19421837545718 0.66932611270284 -0.492113883488128 0.15368080978328 0.767194644005234 -0.486205975162002 0.0479208300603651 0.67660555129746 -0.707148948262114 "MSH6 MUT" "GW843682X_IC_50" 0.183563482830389 0.660385845878234 -1.63017738907849 0.153912249635485 0.767918364613899 -0.900433409980405 0.144579084478893 0.831473272394224 -1.84072945902582 "MYCN MUT" "PF.562271_IC_50" 0.382574524921977 0.798569876743396 -0.312485018135929 0.154242669134699 0.768172290260778 -0.427035832969284 0.00739127830541811 0.383871009534609 -1.08333318690606 "BRCA2 MUT" "Etoposide_IC_50" 0.76199116936531 0.935915464447689 -0.304400105902779 0.154314135895436 0.768172290260778 -0.933217180629783 0.345494917585294 0.908776186051852 -0.906486255730835 "EGFR MUT" "Paclitaxel_IC_50" 0.626619473330332 0.89123540333742 0.407520432404182 0.154371024964776 0.768172290260778 -0.515933285048903 0.244676437990324 0.875707386589409 0.982870198577861 "MET MUT" "Vorinostat_IC_50" 0.00764573364452689 0.153277111731475 1.02556990927308 0.154375548464787 0.768172290260778 0.419859426075347 0.0808607189525267 0.741811190933953 0.612359389943857 "BCR_ABL MUT" "CGP.60474_IC_50" 0.633655317940347 0.89399270048764 -0.446174479452061 0.154601051424251 0.768172290260778 1.25644415561488 0.874962774697235 0.98777404048288 0.146094393780235 "SMARCA4 MUT" "Pyrimethamine_IC_50" 0.119588935807071 0.577525469767589 2.09564595238097 0.154611733762206 0.768172290260778 1.62107539454222 0.310437976919472 0.89718581932126 2.35572529386076 "MYC MUT" "XMD8.85_IC_50" 0.0465430281119685 0.384153004333078 0.755161137546465 0.154729261174464 0.768172290260778 0.475304087500543 0.714844584923959 0.962630898212352 0.144501937933412 "BRCA2 MUT" "Obatoclax.Mesylate_IC_50" 0.152881677506912 0.626553843072858 1.34991036544075 0.154812896894254 0.768172290260778 0.992303164237656 0.285678794156237 0.8879937007725 0.97705563646138 "SMO MUT" "CCT007093_IC_50" 0.185518469129428 0.660621300857439 0.948459374999999 0.154849911992535 0.768172290260778 1.01783039126879 0.125983798316246 0.817150972850516 1.10438035018024 "NRAS MUT" "Roscovitine_IC_50" 0.568254588021899 0.872389778906173 0.22105073529412 0.15504980059802 0.768172290260778 0.502489032729732 0.521406419410437 0.939635632721979 0.27902933234241 "ERBB2 MUT" "SB590885_IC_50" 0.494877853798332 0.843282996121548 0.306537095050965 0.155109914629698 0.768172290260778 -0.550773305182928 0.74882035397785 0.968780465757047 -0.13433845153285 "SETD2 MUT" "RDEA119_IC_50" 0.332470298562916 0.773185226006147 1.60541714455448 0.155120504035999 0.768172290260778 2.15424058451484 0.0742373424984044 0.741621865836141 2.52751880202757 "HRAS MUT" "BIBW2992_IC_50" 0.160418372212426 0.636336191287136 1.0920288113448 0.155192532938559 0.768172290260778 1.06172126456634 0.118310776697324 0.806524749270063 1.12176771902317 "MYC MUT" "FTI.277_IC_50" 0.0308832097172693 0.326128163494731 0.372212476512338 0.155382487405506 0.768172290260778 0.225037134083357 0.373086780764036 0.913948248824328 0.154305899552539 "VHL MUT" "Pyrimethamine_IC_50" 0.915794767948713 0.98476490303336 -0.123747150170649 0.155384847946319 0.768172290260778 -1.41834448620376 0.557447928748878 0.949136321936116 -0.721586825224279 "RUNX1 MUT" "AICAR_IC_50" 0.136048782787367 0.60335156031289 -1.47870678294574 0.155414504654618 0.768172290260778 -1.2560408259657 0.145106929320244 0.831473272394224 -1.37669846136021 "TSC1 MUT" "Bexarotene_IC_50" 0.544402984494219 0.862633715268747 -0.689551966956529 0.155433577930258 0.768172290260778 -1.44004078133408 0.532813937328867 0.943443271455699 -0.675828554196054 "CTNNB1 MUT" "Vinblastine_IC_50" 0.792221475314439 0.948297220782048 0.132155081097195 0.155766662893459 0.768625305988796 0.515501491329957 0.380546076133763 0.915134825237766 -0.450729987459452 "MSH6 MUT" "SL.0101.1_IC_50" 0.935693856879563 0.988214667968534 0.0373640642303429 0.155835750515599 0.768625305988796 0.572357193945667 0.89944335287668 0.988704788932507 0.0559413496701593 "NF1 MUT" "Nilotinib_IC_50" 0.0256623010073534 0.297917510125889 0.794282550295855 0.15586987239828 0.768625305988796 0.411028791902604 0.144838328542777 0.831473272394224 0.496452701668491 "GNAS MUT" "SL.0101.1_IC_50" 0.443068000173806 0.825539266593482 -0.383186814958092 0.155871430704405 0.768625305988796 -0.615436367319506 0.418614672565577 0.922428741067589 -0.387148244210764 "CDKN2a(p14) MUT" "BX.795_IC_50" 0.000596731402042077 0.0332380402971253 -0.503566477192984 0.156219767844219 0.769915515107939 -0.167288426700149 0.0816472868093148 0.742940116960579 -0.251762502727529 "RB1 MUT" "GW.441756_IC_50" 0.0610847944667336 0.446497168443672 0.316493224906653 0.156388788941983 0.769921691833526 0.241112440813533 0.163389061915726 0.839927262232576 0.258542587887868 "SMAD4 MUT" "CHIR.99021_IC_50" 0.195218714156398 0.670691450840608 0.353786816112742 0.156394407394176 0.769921691833526 0.378657794340215 0.232251530276696 0.869962136993019 0.338242594054378 "MAP2K4 MUT" "X681640_IC_50" 0.107126244547177 0.551794991672845 0.800228165289246 0.156658644995442 0.770602280121369 0.602875159517957 0.101703141310635 0.775001254906449 0.850805533007144 "EZH2 MUT" "XMD8.85_IC_50" 0.766860007819316 0.937850808294193 -0.271739379310347 0.156732327811554 0.770602280121369 -1.11705503844542 0.767554981057205 0.969901216545994 0.305407655576773 "PTEN MUT" "Lapatinib_IC_50" 0.875723608118316 0.971594429690931 0.0436253741496599 0.15689374218338 0.770602280121369 0.347138165843181 0.400572737406003 0.916589616820582 0.226112934020322 "CCND3 MUT" "Gemcitabine_IC_50" 0.227651870776769 0.699759797702227 2.45168274956375 0.156975026283239 0.770602280121369 1.92651411873242 0.217052540128194 0.860928912580141 2.35086261241784 "JAK2 MUT" "Bleomycin_IC_50" 0.0496973840707183 0.397265947733618 2.45744590225568 0.156984863735655 0.770602280121369 1.44297608675427 0.16013250199707 0.838901067822678 1.84433986387829 "FLT3 MUT" "X681640_IC_50" 0.416428633386697 0.814099702076568 0.767271203252055 0.157053274070451 0.770602280121369 1.15524586703155 0.0877855356386938 0.755448974813217 1.51806687803469 "STK11 MUT" "ABT.263_IC_50" 0.0407782877854479 0.364613348032389 0.967910792128612 0.157209113745401 0.770651829943398 0.601840926667301 0.535127224807811 0.943443271455699 0.274184778257607 "CDKN2a(p14) MUT" "Lapatinib_IC_50" 0.00343201857526441 0.095249240521635 -0.649913627816504 0.157236923303393 0.770651829943398 -0.293922003520621 0.127214965882433 0.817440977377154 -0.340490962926438 "BRAF MUT" "Etoposide_IC_50" 0.398320190176699 0.80588428316352 -0.293049151216146 0.157487730658241 0.77135290915286 -0.352120688363118 0.0635405120718212 0.70501719149803 -0.728500622102373 "MYC MUT" "CCT018159_IC_50" 0.0887534420389677 0.51316361897661 -0.435054954954956 0.157553673820886 0.77135290915286 -0.33690388878946 0.0994856149117934 0.774133667469059 -0.448982685820308 "FLCN MUT" "Nutlin.3a_IC_50" 0.112215555201248 0.563432092377384 1.48580430588236 0.157722985799365 0.771456288414041 1.20934082958647 0.29496848397556 0.894167310052 1.33730911830726 "MYC MUT" "CI.1040_IC_50" 0.0938166237412962 0.524345774352707 0.486671203067645 0.157748521535852 0.771456288414041 0.368983549962696 0.502170471578899 0.934042323734638 0.179938471450948 "TSC1 MUT" "AUY922_IC_50" 0.10199701147871 0.542024654294532 2.19077738782611 0.157978057202504 0.772153619160944 1.2707971371118 0.0749240641614131 0.741811190933953 2.27238794727536 "KRAS MUT" "Tipifarnib_IC_50" 0.0632965971925494 0.450893824743909 -0.494949331288489 0.158318020215078 0.77322778109554 -0.264471094257295 0.107466988118089 0.792785095696032 -0.483045759280715 "MYCL1 MUT" "JW.7.52.1_IC_50" 0.354976388720697 0.785252181551816 1.02553957044674 0.158371955164147 0.77322778109554 0.9537471463741 0.837737424906212 0.981704379975756 -0.240457788124462 "BRAF MUT" "Paclitaxel_IC_50" 0.944874113358274 0.990147156460271 -0.0407660672877846 0.158514810067446 0.773500015499443 0.394023292143207 0.522682272622813 0.940235216358761 -0.485288026013109 "BRCA2 MUT" "ABT.888_IC_50" 0.18099647523874 0.658636992153339 0.634969360153254 0.158771454474248 0.774326901255245 0.568395730829624 0.313848027063655 0.900294798053993 0.451706328533088 "SMAD4 MUT" "Embelin_IC_50" 0.503326088384925 0.846758664699095 0.182536874528066 0.159023051799524 0.774547229803802 0.314283916721141 0.771112316859804 0.969901216545994 0.0843049691253639 "SMARCA4 MUT" "VX.680_IC_50" 0.787544708846799 0.946449577332088 -0.411155668941976 0.159051599970616 0.774547229803802 -1.39586723404756 0.390801336609629 0.915926348152589 -2.31940235965072 "MYCL1 MUT" "EHT.1864_IC_50" 0.163237439112884 0.638639513991862 -0.792236179775287 0.159184975441848 0.774547229803802 -0.793459441206727 0.44785749328946 0.925809648901546 -0.474910789267016 "MDM2 MUT" "AUY922_IC_50" 0.921360268355927 0.986093099936007 0.0596323957671958 0.159272209854671 0.774547229803802 -0.570317928632319 0.846967212710749 0.98378870157398 0.111020027396272 "CDKN2a(p14) MUT" "IPA.3_IC_50" 0.479468722793107 0.836304203722611 0.126671673586629 0.159557498078966 0.774547229803802 0.221379429546464 0.331352500118247 0.902810042912437 0.180414148717751 "CCND1 MUT" "CHIR.99021_IC_50" 0.114757760560145 0.567167686753817 0.445483517517521 0.159569322243174 0.774547229803802 0.380437774914273 0.150706511418262 0.831473272394224 0.420101832782468 "ERBB2 MUT" "Embelin_IC_50" 0.809306644872801 0.952641225877339 -0.0850532636554619 0.159634342742627 0.774547229803802 -0.406244235055867 0.393758746551809 0.915926348152589 -0.315195980030269 "EWS_FLI1 MUT" "GW.441756_IC_50" 0.146674867332723 0.619919550890177 -0.47772726851596 0.159679106942545 0.774547229803802 -0.49465886310091 0.315582504802121 0.900294798053993 -0.378350766597174 "BRCA2 MUT" "Cyclopamine_IC_50" 0.596024899009536 0.879149639202396 -0.555935616438364 0.159800354421071 0.774547229803802 -1.35769357886291 0.625850610121878 0.951091592828953 -0.520124817498137 "KRAS MUT" "Camptothecin_IC_50" 0.00154550537826572 0.0574294278844261 0.83435051590634 0.159806396556194 0.774547229803802 0.250155512823054 0.247770632099328 0.875707386589409 0.313590518610856 "FAM123B MUT" "TW.37_IC_50" 0.958668585288103 0.993432616972253 -0.0351229774774777 0.159932753523108 0.774547229803802 -0.864255957235974 0.610241067148444 0.949930222127033 -0.335912539509662 "KDR MUT" "PD.0325901_IC_50" 0.211556910976671 0.685456740745646 1.6240628829365 0.159942948797536 0.774547229803802 1.71735838530209 0.143762534489767 0.831473272394224 1.68157010092155 "KIT MUT" "CEP.701_IC_50" 0.978148424773307 0.996276778834563 -0.0253850480952387 0.159950413180968 0.774547229803802 0.955340203555063 0.96970430822619 0.997173634484198 -0.0321759742032584 "MLH1 MUT" "ATRA_IC_50" 0.788661396585598 0.946884123709166 -0.140894906443074 0.160065295001962 0.774681136192057 0.588106089651773 0.24767244622183 0.875707386589409 0.53731837971211 "SMO MUT" "Obatoclax.Mesylate_IC_50" 0.820043909655732 0.955629000670661 0.371127907826089 0.160172765670789 0.774779047887948 1.67484299099806 0.965689063124033 0.997126446878798 0.0670327532030379 "SMARCA4 MUT" "Dasatinib_IC_50" 0.444269322441538 0.825606373270691 1.73489643913537 0.160412467634036 0.775516126868737 2.62492341485201 0.381010697703214 0.915134825237766 2.96786274320469 "SMARCA4 MUT" "ABT.263_IC_50" 0.0749228744156468 0.480599432660364 1.23543205595238 0.160585439726633 0.775518247756474 0.870689128766705 0.175525983474445 0.846738869764556 0.931245027719147 "CDH1 MUT" "Bosutinib_IC_50" 0.197239877920719 0.673909677569775 0.824991870905583 0.160587552935948 0.775518247756474 0.745559286817455 0.747830930298289 0.968780465757047 0.20479931089461 "FAM123B MUT" "PD.173074_IC_50" 0.382216696062426 0.798569876743396 -0.728632681017619 0.160945240216267 0.77631692134893 -0.999428033269708 0.16873728985823 0.84067330207935 -1.06211949313282 "BRCA1 MUT" "TW.37_IC_50" 0.066444988137561 0.458546662429304 1.24156603153154 0.160948280177415 0.77631692134893 0.86332682400287 0.112789007557548 0.798150737943098 1.02403036160117 "PDGFRA MUT" "Pazopanib_IC_50" 0.0301493151106524 0.321435855339381 -1.83120975524476 0.161097238264117 0.77631692134893 -1.00722056063505 0.351277839856002 0.910675149838292 -0.732053493840209 "CDH1 MUT" "CMK_IC_50" 0.173118390703635 0.65113493295882 -1.04777707216495 0.161102681616685 0.77631692134893 -1.01072858268606 0.142948410219353 0.831473272394224 -1.18228587121439 "TP53 MUT" "FTI.277_IC_50" 0.061422443373628 0.447125180000976 0.180501690493815 0.161388385646924 0.77631692134893 0.127975825373796 0.193357097125207 0.851001889249827 0.128641710441036 "FLCN MUT" "AZD7762_IC_50" 0.362966867794812 0.787293170741334 -0.941097650763372 0.161438348741713 0.77631692134893 -1.13081919815153 0.275272776533532 0.883780956691668 -1.76837332700455 "CCND3 MUT" "Vorinostat_IC_50" 0.112799587420568 0.563938179281427 1.42037167716538 0.1615256000732 0.77631692134893 0.956430953102675 0.156596645202667 0.837288218996252 1.15072765244009 "MS-HL MUT" "NVP.BEZ235_IC_50" 0.595325555241589 0.878837476080544 0.112705996067416 0.16153389345909 0.77631692134893 0.214362705719066 0.889455015906437 0.988301482344111 0.0306523025265572 "NRAS MUT" "Obatoclax.Mesylate_IC_50" 0.0101308545188031 0.178516109090258 -0.946304135157983 0.161616485378296 0.77631692134893 -0.390040474355854 0.454324593725373 0.925809648901546 -0.302761539894442 "KDM5C MUT" "CI.1040_IC_50" 0.294863554532259 0.747036827777118 1.3263588721374 0.161627067624611 0.77631692134893 1.59371938248575 0.270048128405063 0.878819138279722 1.22134153367251 "EZH2 MUT" "BMS.536924_IC_50" 0.0203931716920965 0.258938579544408 2.87251988737202 0.162060471811423 0.777977864949863 1.28122707582446 0.07029781182802 0.727487375216157 2.44120989322293 "SMARCA4 MUT" "PLX4720_IC_50" 0.0748908071641614 0.480599432660364 1.07337939417475 0.162149537214072 0.777984894650555 0.744078105809411 0.413328645813746 0.921714070263062 0.510123653283971 "MYCN MUT" "Camptothecin_IC_50" 0.138134763597 0.606087209949663 -0.777700125180594 0.162409930850838 0.778813496698863 -0.476033480371143 0.707412310452862 0.962630898212352 -0.203974620352871 "MSH2 MUT" "PD.0332991_IC_50" 0.201140274947996 0.674012093366938 -0.958422991369054 0.162621162121952 0.779238321481519 -0.836887635744748 0.360847649163092 0.91161229252998 -0.646457725370087 "MYCL1 MUT" "KU.55933_IC_50" 0.309059229771301 0.75674113273833 -0.524063419483109 0.162746043135694 0.779238321481519 -0.637271825480121 0.501677974475419 0.934042323734638 -0.379262811518996 "NRAS MUT" "Pazopanib_IC_50" 0.97641525278493 0.996276778834563 -0.00892642963951961 0.162841534861651 0.779238321481519 -0.370002497222239 0.779233169937311 0.972337708041191 0.0883676671118653 "PIK3R1 MUT" "Roscovitine_IC_50" 0.66786617030355 0.905919726780999 -0.32367205574913 0.162849490448114 0.779238321481519 -0.925121113938518 0.832785077436219 0.981482581683432 -0.157760932164073 "ERBB2 MUT" "PF.02341066_IC_50" 0.320670700230493 0.762015213745527 0.727862850847456 0.162948590813096 0.779292641363007 0.970413804180146 0.273426749716578 0.882167181782537 0.819911782751737 "PIK3R1 MUT" "Lenalidomide_IC_50" 0.115457053002131 0.568406140842131 0.594608973128592 0.163133096756447 0.779682291888693 0.462308689874525 0.121698947060278 0.809590452621284 0.558462710925743 "VHL MUT" "PAC.1_IC_50" 0.285327763810665 0.740302864659114 -0.656277119507907 0.163205650334543 0.779682291888693 -0.721855817874958 0.127061073211316 0.817150972850516 -0.978866043510177 "SOCS1 MUT" "PD.0325901_IC_50" 0.125126277967164 0.586409749143208 -2.43835404356438 0.163462547480209 0.779748567412306 -2.0826117871713 0.0105576965415579 0.450367315182713 -3.54386203842236 "PDGFRA MUT" "BI.D1870_IC_50" 0.272474114470896 0.734000646544246 0.793117469348654 0.163515610666362 0.779748567412306 0.868807263260126 0.423697504517885 0.922428741067589 0.556753542777876 "PIK3CA MUT" "Lapatinib_IC_50" 0.0796002681493445 0.490582915637979 -0.883674416873446 0.163553621760448 0.779748567412306 -0.60713141122082 0.200994634035347 0.851001889249827 -0.620750468036731 "SMARCA4 MUT" "Sunitinib_IC_50" 0.932927320073453 0.98681842896288 -0.115138076222981 0.163570721888202 0.779748567412306 -1.40465052599121 0.412547365362589 0.921714070263062 -1.68141263827718 "CDKN2a(p14) MUT" "MK.2206_IC_50" 0.498870469716311 0.845109283443017 -0.113068358151684 0.163663160455928 0.779770669532777 0.193967969258552 0.727173534154599 0.965402608571648 -0.0637721863958208 "NF2 MUT" "CGP.082996_IC_50" 0.912546614946973 0.983057555475991 0.0577942307692307 0.163909202170231 0.780145354687139 0.633099089124566 0.442093913449977 0.924472815010418 0.43799824483615 "FAM123B MUT" "Bexarotene_IC_50" 0.192337179164889 0.668037820564704 0.939862550699314 0.163917490355388 0.780145354687139 0.893690944116436 0.164823335263241 0.84067330207935 0.969597169340943 "MYC MUT" "MS.275_IC_50" 0.446599581353219 0.825892730562573 0.348868559259258 0.164079053728771 0.780148986556563 0.538382381429542 0.765216998386917 0.969901216545994 0.150336396246637 "MYC MUT" "VX.702_IC_50" 0.485016363099428 0.83972091053812 0.170145317073173 0.16417277841043 0.780148986556563 0.278304674571845 0.511568654981851 0.939086342216131 0.155621365102836 "JAK2 MUT" "Gefitinib_IC_50" 0.44360668845096 0.825606373270691 -0.47317626792556 0.164181787622364 0.780148986556563 -0.773078704349591 0.555447874388315 0.948071221654821 -0.357277416738866 "KDM5C MUT" "ABT.888_IC_50" 0.455743748226153 0.828966839128293 0.558524620952392 0.164284901254622 0.780221501626899 0.88438533199714 0.304687029006795 0.895767221521364 0.713145561018261 "SMAD4 MUT" "Elesclomol_IC_50" 0.758264937271772 0.934762260113025 -0.132430503172495 0.16439914054457 0.780346748891676 -0.50733697891706 0.286552943518447 0.888460548829126 -0.459861662363455 "NF2 MUT" "Parthenolide_IC_50" 0.471399033084158 0.832801832667676 0.369187266435982 0.164635479798449 0.781021902223174 0.681442944377921 0.252811437037975 0.875707386589409 0.662048403096126 "MLL_AFF1 MUT" "MK.2206_IC_50" 0.192809765382622 0.668215486666746 -1.6461123051546 0.164717264144128 0.781021902223174 -1.42549182792413 0.518140948788193 0.939635632721979 -0.807099837738925 "BRCA2 MUT" "Gefitinib_IC_50" 0.385609799546497 0.798746759187088 -0.632776112595428 0.164895227960722 0.78144851628558 -0.917812142302676 0.436196645563363 0.922569292988365 -0.516619904985128 "BRCA1 MUT" "AICAR_IC_50" 0.963442923659368 0.994159243759316 -0.0394550970873779 0.165027633428007 0.781487973255099 -1.07100155067728 0.788470453094133 0.975265472692061 -0.22094105066747 "VHL MUT" "SB590885_IC_50" 0.0746850842157123 0.480599432660364 1.15446246926228 0.165104883769319 0.781487973255099 0.755513549741076 0.46044300360391 0.928307449490652 0.454555856096376 "ALK MUT" "GW843682X_IC_50" 0.29558739149657 0.747204646998838 1.28287564846417 0.165285175500754 0.781487973255099 0.87745260248481 0.287698989532708 0.888563331668781 1.57977408230286 "FGFR2 MUT" "Bexarotene_IC_50" 0.00422760389025418 0.107579799854864 2.29723855846425 0.165304818909716 0.781487973255099 1.01176496291756 0.0326572504863697 0.618827479917328 1.89161458106151 "VHL MUT" "Elesclomol_IC_50" 0.893927356115851 0.976022725555062 0.103468995201532 0.165506670855794 0.781487973255099 0.898993263564545 0.369300743959459 0.913948248824328 0.713347852634065 "CDKN2C MUT" "ABT.888_IC_50" 0.67065486755601 0.906916702390321 -0.160163846820808 0.165581108251452 0.781487973255099 -0.442018418756749 0.453939082150543 0.925809648901546 -0.282517234256965 "CDKN2C MUT" "Nilotinib_IC_50" 0.62254720306539 0.889024233867781 -0.287294715930901 0.165703614974968 0.781487973255099 -0.657233419328507 0.878299046896562 0.987955687349291 -0.086096821067265 "SMARCA4 MUT" "CCT018159_IC_50" 0.215665199674261 0.688608753079032 -0.559769069767445 0.165859826350126 0.781487973255099 -0.577592814015957 0.356230494464246 0.91161229252998 -0.481125131427415 "HRAS MUT" "BMS.754807_IC_50" 0.337404003672912 0.77528718153147 -0.991570047202788 0.165871599157963 0.781487973255099 -1.19767575946902 0.404875489627628 0.917738443946647 -0.845146931730481 "KIT MUT" "Lenalidomide_IC_50" 0.131977024078578 0.597090143067676 0.801703809523814 0.165906617208212 0.781487973255099 0.648454277250163 0.223761575056534 0.86643108387559 0.625848100935964 "ALK MUT" "KIN001.135_IC_50" 0.188177460200708 0.663245512002727 0.592600112612615 0.165958962461095 0.781487973255099 0.609102960314411 0.236751506857382 0.872082178515309 0.613585048765393 "SETD2 MUT" "Salubrinal_IC_50" 0.679995526986163 0.909220155851267 -0.503297440273043 0.165973461416854 0.781487973255099 -1.40911761060425 0.613010905497263 0.949930222127033 -0.619505936083705 "EWS_FLI1 MUT" "PHA.665752_IC_50" 0.0958877612739263 0.529259917882996 -0.699350541050645 0.166047495274448 0.781487973255099 -0.637538771404311 0.0642012643816224 0.706338462496173 -0.912147874055911 "FLT3 MUT" "WH.4.023_IC_50" 0.107035902901991 0.551794991672845 -3.31390273265071 0.166238974345897 0.781864912065916 -2.49487285683594 0.0761993620832536 0.741811190933953 -3.42444494132898 "KRAS MUT" "ZM.447439_IC_50" 0.180988759652811 0.658636992153339 0.256054026975651 0.1663036616251 0.781864912065916 -0.224446461384022 0.382392384461908 0.915134825237766 -0.184901537643919 "MDM2 MUT" "ATRA_IC_50" 0.0399688729879209 0.361141839503332 1.12904539728682 0.166865628371226 0.783455120972135 0.598843616452222 0.0178933119974409 0.513211661128791 1.13390723833907 "FGFR2 MUT" "AZD6244_IC_50" 0.176873910184488 0.656147533980133 2.14175769896905 0.166871951707662 0.783455120972135 2.01215368786037 0.93031153673858 0.99422596912377 0.174935467507636 "EZH2 MUT" "NU.7441_IC_50" 0.383890527671187 0.798569876743396 0.559692011904766 0.166906552063876 0.783455120972135 0.775372288550821 0.489873518564913 0.933639405738697 0.42653191823956 "PIK3CA MUT" "X681640_IC_50" 0.0213166038711784 0.266637688704135 0.56881192841164 0.167710451989213 0.786812743854305 0.295225178525693 0.337050331460006 0.905430766021494 0.246500836871317 "MAP2K4 MUT" "Bleomycin_IC_50" 0.265074605705025 0.726697783882931 -1.0306242498636 0.168105025358761 0.78817921288915 -1.04005399883288 0.177628807699232 0.848722027112292 -1.3201611834875 "MLLT3 MUT" "PLX4720_IC_50" 0.337644268654706 0.775438001014338 0.446697990504864 0.168239376644598 0.78817921288915 0.567865061424905 0.397378643638853 0.916480913435499 0.377626424141041 "FLT3 MUT" "AKT.inhibitor.VIII_IC_50" 0.117724110298094 0.573824271985386 -1.2555948633218 0.168267963927241 0.78817921288915 -0.959264807705595 0.0983241824250346 0.774133667469059 -1.30446928950839 "MET MUT" "Roscovitine_IC_50" 0.318769300032245 0.761267128904167 -1.18213655172414 0.168389521011963 0.78833087233404 -1.43065710461523 0.287781341992175 0.888563331668781 -1.26137921564981 "BRAF MUT" "Bosutinib_IC_50" 0.510856915203258 0.849393770898084 0.168334358936823 0.168477873627971 0.78833087233404 0.31905958451127 0.239875629513872 0.875707386589409 -0.332063530007729 "TET2 MUT" "Axitinib_IC_50" 0.715493631984596 0.920719574063407 -0.37528063624841 0.168694287718653 0.788659955392579 1.21271170137348 0.476666947826112 0.929855889225741 0.79152048204194 "SETD2 MUT" "Tipifarnib_IC_50" 0.125532635435859 0.586857535554275 2.42683733217394 0.168738150060344 0.788659955392579 1.45947453360669 0.107805511793295 0.792785095696032 2.50848531968457 "FGFR2 MUT" "Gefitinib_IC_50" 0.209465585315061 0.683860903264959 1.44259480265654 0.168838960657898 0.788659955392579 1.42989906225125 0.32133408867391 0.900918773778407 1.44940369090955 "CCND1 MUT" "Vinorelbine_IC_50" 0.818783233892635 0.95524539465489 -0.0914242752752761 0.168940604849719 0.788659955392579 -0.405488166241461 0.602686952547528 0.949657634568742 -0.218865707477908 "CDK4 MUT" "AP.24534_IC_50" 0.294957940032348 0.747036827777118 -1.03153290505227 0.169017318274322 0.788659955392579 -1.22474900164511 0.428972584972257 0.922428741067589 -0.777688248390121 "MYC MUT" "AG.014699_IC_50" 0.133602710647474 0.600164731037035 -0.389651972617742 0.169147296245487 0.788659955392579 -0.315206179619075 0.100839396681533 0.774133667469059 -0.416787911813968 "FBXW7 MUT" "AMG.706_IC_50" 0.598038332549952 0.879232253518807 0.147312529563934 0.169169824909679 0.788659955392579 0.355172400866082 0.657657683763673 0.958313128388245 0.122002752351554 "CDK4 MUT" "SL.0101.1_IC_50" 0.0458998780744209 0.382398515177234 0.774256686159837 0.169356773332506 0.78911726336096 0.466610305742014 0.0806807583337291 0.741811190933953 0.682495812468513 "KDM5C MUT" "Bryostatin.1_IC_50" 0.277695476450246 0.735524463571321 -0.6862667225131 0.169692931907531 0.789750756168606 -0.81845836780856 0.138733664858216 0.831473272394224 -0.890710231622271 "FGFR2 MUT" "Z.LLNle.CHO_IC_50" 0.0194741642503722 0.252787916799651 2.45003533447099 0.169810717570539 0.789750756168606 1.36446092606485 0.222639998525614 0.865601665610206 1.52385712089459 "MSH6 MUT" "AG.014699_IC_50" 0.137447472508659 0.605191374987308 1.07145912387389 0.169833761422827 0.789750756168606 0.869665456828244 0.145230737701879 0.831473272394224 0.971393665532414 "MET MUT" "AZ628_IC_50" 0.48582009825573 0.840227515600611 -1.3337803707483 0.169848434217097 0.789750756168606 -1.94219004949769 0.377261991176897 0.914419412871569 1.4606692571781 "GNAS MUT" "MK.2206_IC_50" 0.492287662014985 0.842990705166559 -0.436961350208764 0.169949777746964 0.789808464767548 -0.69448190183438 0.452008367642906 0.925809648901546 -0.466039493212155 "RB1 MUT" "AG.014699_IC_50" 0.520515540323284 0.852599738673405 0.156648057637998 0.170605198769194 0.790267045709456 0.299571551485879 0.139432893965535 0.831473272394224 0.361857961449961 "CDH1 MUT" "AZ628_IC_50" 0.142716311301569 0.615572394691227 1.78061969415809 0.171105784726906 0.790267045709456 1.27089072855616 0.0732874306142333 0.739487156743738 1.92720644231518 "MSH2 MUT" "BMS.754807_IC_50" 0.573156201011995 0.872620551543038 0.493174032832087 0.171175634701969 0.790267045709456 1.00424782041588 0.714070915701753 0.962630898212352 0.317620387554269 "KDR MUT" "Bosutinib_IC_50" 0.241811562629881 0.711340033600749 1.21721405407126 0.171211030346331 0.790267045709456 1.1645908055501 0.59288661328675 0.949294892873838 0.520233124008224 "MET MUT" "QS11_IC_50" 0.766986873172021 0.937850808294193 0.17690505669772 0.171286622869989 0.790267045709456 0.602097598444184 0.939130963380489 0.994831655017307 -0.0445912959513699 "SMAD4 MUT" "PD.0332991_IC_50" 0.682138520413819 0.909924137549646 0.16897663048956 0.171364319434926 0.790267045709456 -0.463255541437893 0.770974553029342 0.969901216545994 -0.120195704857684 "MYCN MUT" "Erlotinib_IC_50" 0.95635748480368 0.993149067182119 0.0223706731946143 0.171364758704238 0.790267045709456 -0.510819235163679 0.0830558490802567 0.745860856369627 -0.809522664782754 "BRCA2 MUT" "AZD.2281_IC_50" 0.146949422501351 0.619919550890177 1.08908113636363 0.171469307005942 0.790267045709456 0.778829287017372 0.520781195646063 0.939635632721979 0.425827433653712 "KDM5C MUT" "KU.55933_IC_50" 0.160771894933483 0.636336191287136 -1.01835461133071 0.171471915702825 0.790267045709456 -0.883458347297006 0.198983547352687 0.851001889249827 -0.913641098068684 "AKT2 MUT" "PF.562271_IC_50" 0.654339366350757 0.900959366288538 0.2612855336646 0.171552805351431 0.790267045709456 0.649049837493841 0.459115372336906 0.927632358897555 0.429238304367639 "TP53 MUT" "A.770041_IC_50" 0.128258675299799 0.588664235316545 0.47017380741875 0.171719437745884 0.790267045709456 0.370389698999903 0.199964021266856 0.851001889249827 0.414495549901081 "JAK2 MUT" "X681640_IC_50" 0.720486243565365 0.922791798255554 -0.239682501022494 0.171743487987273 0.790267045709456 -0.781752051689267 0.557731630973234 0.949255388017112 -0.407176593964743 "PTEN MUT" "Cytarabine_IC_50" 0.647762836028419 0.89760988403314 -0.112970940528633 0.171752978049773 0.790267045709456 0.261235618259659 0.922781281885632 0.993931766508607 -0.0241115287781803 "CDK4 MUT" "X681640_IC_50" 0.0163331038013305 0.233354840019847 1.24756779793815 0.171999864397268 0.790267045709456 0.609095524825638 0.0442693324729165 0.659657620288543 1.02866567917362 "KIT MUT" "GSK269962A_IC_50" 0.783690343942216 0.944974629816073 0.450242 0.172178132067574 0.790267045709456 2.15813795050695 0.206473366338648 0.853446327418758 2.07781817387131 "CDK4 MUT" "WZ.1.84_IC_50" 0.612965756081298 0.884985642039059 0.60121843537415 0.172189964607271 0.790267045709456 1.35549081293041 0.379337470613228 0.915134825237766 0.997899194956906 "FLT3 MUT" "FTI.277_IC_50" 0.172763988424606 0.650961807890931 0.753160425605538 0.172531001353765 0.790267045709456 0.693603443251634 0.361636929767978 0.91161229252998 0.481739736701055 "PDGFRA MUT" "AS601245_IC_50" 0.0958656835256899 0.529259917882996 -1.34573246853148 0.172581193287245 0.790267045709456 -0.883497173965106 0.21138693672674 0.855272470862467 -1.0152993002122 "RB1 MUT" "BX.795_IC_50" 0.66361830684127 0.903538553756266 -0.106511228356158 0.172622593226741 0.790267045709456 -0.262729016171836 0.845403330314622 0.98378870157398 0.0466842789938543 "EP300 MUT" "DMOG_IC_50" 0.27286658941445 0.734000646544246 -1.13546148531949 0.172647819997265 0.790267045709456 -1.27647470478779 0.264961076568379 0.877052916121269 -1.08314182298793 "RUNX1 MUT" "AMG.706_IC_50" 0.350742696322693 0.784966682190403 -0.692617005870846 0.172796100466679 0.790267045709456 -0.92823836330481 0.207344026913323 0.853446327418758 -0.855037185468757 "PTEN MUT" "NVP.BEZ235_IC_50" 0.000973326783951342 0.0445762092657074 -0.651907743513962 0.172857045995234 0.790267045709456 -0.199274670166394 0.036952351734686 0.6397150794459 -0.427432110213616 "MS-HL MUT" "Embelin_IC_50" 0.0345449344482976 0.342986337003385 -0.387489041424175 0.172912002053268 0.790267045709456 -0.201098438711848 0.010852224462234 0.450367315182713 -0.51392994536874 "MET MUT" "AZD6482_IC_50" 0.119296480513326 0.577057450057752 -0.931423919280363 0.172925328328881 0.790267045709456 -0.690355735999684 0.0660695297416496 0.712070726599122 -1.07143181130958 "ALK MUT" "Thapsigargin_IC_50" 0.299099326111026 0.750344870252218 -2.11554312000001 0.17300792748485 0.790267045709456 -2.12020867717712 0.330669405481557 0.902810042912437 -2.71313301565603 "TP53 MUT" "VX.702_IC_50" 0.221888642604087 0.694197984755969 0.169032344480519 0.173040096892171 0.790267045709456 0.160456520948655 0.654217203029764 0.958313128388245 -0.0618830562968065 "MS-HL MUT" "BIBW2992_IC_50" 0.0810881013861292 0.494604003028992 -0.443466087097211 0.173094459926075 0.790267045709456 -0.334124213445731 0.246021840945619 0.875707386589409 -0.298027921822873 "CDKN2A MUT" "AZD6482_IC_50" 0.0071381382084962 0.147707385845685 -0.441826878649737 0.173159286685855 0.790267045709456 -0.19891122106315 0.529719041923124 0.94315521189351 -0.11586727715872 "BRAF MUT" "Shikonin_IC_50" 0.715655398466459 0.920719574063407 -0.105585494842159 0.173242677842183 0.790267045709456 0.365031773281327 0.218241985925824 0.860928912580141 -0.416245946336106 "RB1 MUT" "LFM.A13_IC_50" 0.559639843978413 0.869669545821922 -0.0843798167585844 0.173250177782211 0.790267045709456 -0.190135294721238 0.40592309415964 0.918000323669952 -0.135816501425028 "CCND2 MUT" "Pazopanib_IC_50" 0.438796647514278 0.824054351147029 -0.844235157375136 0.17343631748463 0.790267045709456 -1.25429607709173 0.123644433242366 0.814000156875798 -1.8716463355931 "CDK6 MUT" "Midostaurin_IC_50" 0.482412674655405 0.83890874556778 -0.440829940081441 0.17351353776481 0.790267045709456 -0.659378042578623 0.589558893276414 0.949294892873838 -0.325764784624484 "MYCN MUT" "Epothilone.B_IC_50" 0.884413889628862 0.974262585935532 0.0772284955116679 0.173537239764765 0.790267045709456 -0.422484411077747 0.0324356477138288 0.618827479917328 -1.28322599731656 "SMAD4 MUT" "AKT.inhibitor.VIII_IC_50" 0.382359694472726 0.798569876743396 -0.266404267568749 0.173642079355163 0.790267045709456 -0.367330587692731 0.842751124208119 0.982859190294459 -0.0635038953400317 "IDH1 MUT" "ATRA_IC_50" 0.281787276230339 0.738375640008268 1.31465936068704 0.174149552769038 0.790267045709456 1.29875909627649 0.300814299895159 0.894167310052 1.11516838245776 "PTEN MUT" "KU.55933_IC_50" 0.791206989943669 0.94790644179192 0.042263281845919 0.174158188962654 0.790267045709456 0.196720799905756 0.875873667641051 0.987838063957761 -0.0268825978363246 "CDH1 MUT" "Thapsigargin_IC_50" 0.0297815430065164 0.320205670025269 2.09649067957748 0.174224320970517 0.790267045709456 1.01527371644026 0.09986968373722 0.774133667469059 1.65307751618862 "FBXW7 MUT" "NVP.TAE684_IC_50" 0.615285661190885 0.885815598771911 0.417482522336775 0.174246084297142 0.790267045709456 0.936174374986025 0.663952162864318 0.959206771190239 0.371520307034312 "ALK MUT" "BMS.708163_IC_50" 0.174609811779243 0.652381042663635 1.166554515625 0.174311163247584 0.790267045709456 1.18181416631622 0.114221108811262 0.799692247086917 1.39146725671731 "PTEN MUT" "Embelin_IC_50" 0.210386605660931 0.684261946425694 -0.210482697752271 0.174328699791398 0.790267045709456 -0.186504850468289 0.244408196466539 0.875707386589409 -0.209526043292257 "RB1 MUT" "PHA.665752_IC_50" 0.293235586658538 0.747036827777118 0.237095936114378 0.174437324601478 0.790267045709456 0.317782648316665 0.826888090428116 0.980698467734194 0.0593191136923244 "FLCN MUT" "BMS.536924_IC_50" 0.128180123923011 0.588664235316545 2.17787313605443 0.174468382298548 0.790267045709456 1.43673989621934 0.551715265356167 0.947060194029534 1.42827005056701 "NRAS MUT" "VX.680_IC_50" 0.256053941329666 0.720311238267775 -0.675312163290048 0.174485895307811 0.790267045709456 -0.547209423727472 0.37179459010688 0.913948248824328 -0.616349295247543 "ALK MUT" "IPA.3_IC_50" 0.247058513281078 0.714668105985286 -1.69149898086957 0.174489385662021 0.790267045709456 -1.66630904140197 0.0815676462802416 0.742940116960579 -3.32916126514991 "BRCA2 MUT" "Bexarotene_IC_50" 0.559858300482071 0.869704664436116 -0.384274426736722 0.174492976040813 0.790267045709456 -0.801734098915523 0.40627362738048 0.918095695869223 -0.527861892605721 "IDH1 MUT" "AMG.706_IC_50" 0.293477404666442 0.747036827777118 -0.953936308593741 0.174510797155074 0.790267045709456 -1.12867259517457 0.39964622666291 0.916480913435499 -0.709420095672269 "CDKN2C MUT" "GW843682X_IC_50" 0.842505438931469 0.960245047977092 0.199840034364262 0.17451725562718 0.790267045709456 0.705528533684994 0.904107395770674 0.988746233284632 0.152576843847179 "EP300 MUT" "SL.0101.1_IC_50" 0.456345386495548 0.828966839128293 -0.524750833333326 0.17453963334965 0.790267045709456 -0.837658568791646 0.347910778899855 0.909999728614578 -0.631578867581325 "FBXW7 MUT" "Parthenolide_IC_50" 0.657259346143989 0.901751651084414 0.227508858131485 0.175009426029827 0.790267045709456 0.650424109171349 0.807748877381061 0.977383317127464 0.132708112935345 "KDM5C MUT" "GW843682X_IC_50" 0.244353109146144 0.713407040228131 -1.42757372013652 0.175054016272972 0.790267045709456 -0.856854374696626 0.347127079670346 0.909751579693109 -1.19066369797068 "MSH6 MUT" "BIRB.0796_IC_50" 0.370976560971169 0.790579328077906 0.413777527472524 0.175108042435454 0.790267045709456 0.599970791725218 0.361323081307463 0.91161229252998 0.415394099237014 "VHL MUT" "AZD.0530_IC_50" 0.0911019165586834 0.516507787943737 -1.53709199659864 0.175108281532284 0.790267045709456 -1.07811979944531 0.456913746496448 0.925841766232465 0.746694540552327 "TET2 MUT" "Gemcitabine_IC_50" 0.60203041467982 0.880745626033854 -1.22325422531938 0.175120256140324 0.790267045709456 2.14842616053446 0.685814555661605 0.961100601384891 -1.08912407145721 "SMAD4 MUT" "Dasatinib_IC_50" 0.0365329862676781 0.349245910703174 -3.11565856154226 0.175150639504415 0.790267045709456 -1.71198800788895 0.153937040761078 0.835611501078903 -1.95889785645115 "NF2 MUT" "Pazopanib_IC_50" 0.0660804264658478 0.458177989025628 -0.768699311151086 0.175163513275005 0.790267045709456 -0.487029729343057 0.607889409582795 0.949657634568742 -0.21160350334512 "ALK MUT" "BI.2536_IC_50" 0.216082883169592 0.688608753079032 1.41054083447099 0.17521561736229 0.790267045709456 0.918630134527232 0.697530084243843 0.961100601384891 0.537596063978277 "NOTCH1 MUT" "PF.02341066_IC_50" 0.0132066218764171 0.207589396255682 -1.23187041491035 0.175265628995839 0.790267045709456 -0.652397812498503 0.196279816431389 0.851001889249827 -0.729156313699252 "BRCA1 MUT" "Lapatinib_IC_50" 0.186438182242241 0.662380873013605 -1.6673626551724 0.175320146758838 0.790267045709456 -1.47003516986072 0.513576435408934 0.939635632721979 -0.733554749070265 "CCND1 MUT" "PF.02341066_IC_50" 0.0548772711575071 0.418465152800335 0.917184170138895 0.175373574226239 0.790267045709456 0.609626371107666 0.24021874071149 0.875707386589409 0.640765446497993 "SETD2 MUT" "Pazopanib_IC_50" 0.844226450267326 0.960498931426639 0.262246613913047 0.175479669911434 0.790267045709456 1.54777372442903 0.583419618385084 0.949294892873838 0.668968880789546 "MS-HL MUT" "EHT.1864_IC_50" 0.150739154894947 0.625297340409797 -0.282494220835127 0.175517349403288 0.790267045709456 -0.26599022343131 0.0653441310077881 0.711992560878964 -0.38613102929835 "FAM123B MUT" "SL.0101.1_IC_50" 0.119204896584294 0.577057450057752 0.950663391136816 0.175565463482126 0.790267045709456 0.722003545705759 0.206139511204776 0.853446327418758 0.753393987984354 "EGFR MUT" "Shikonin_IC_50" 0.198632238140944 0.674012093366938 0.559074038267096 0.175798937094068 0.79091710249869 0.496800412903494 0.135309613058332 0.828937189282754 0.665154052245111 "NRAS MUT" "AZD6482_IC_50" 0.0330065676388006 0.335007231085929 0.670252420899473 0.17593289495626 0.791119007648884 0.370326441098244 0.112091271758157 0.797376436030023 0.558197543389026 "PIK3CA MUT" "PLX4720_IC_50" 0.00719699037195945 0.147954795123546 0.752750827368427 0.176265748333638 0.791913369338084 0.339759593046638 0.042123268570206 0.658180729724545 0.571313114604861 "MYCL1 MUT" "GDC0941_IC_50" 0.553363976034577 0.866799981376517 -0.442140835403723 0.176298395138268 0.791913369338084 -0.80843847485385 0.659045375149411 0.958313128388245 -0.363311162331833 "APC MUT" "NU.7441_IC_50" 0.000462412466434961 0.0283219663062682 0.922934535969766 0.176377057150178 0.791913369338084 0.331442325045266 0.0383750952618634 0.645472009508728 0.649627836989551 "ALK MUT" "BIBW2992_IC_50" 0.459933807938256 0.828966839128293 -0.992632847248573 0.17652710593067 0.792066160890498 -1.75036789975807 0.129151103134536 0.820170087278083 -1.89247910180188 "MYCN MUT" "Z.LLNle.CHO_IC_50" 0.0131506262581299 0.207480784061478 1.01390029662338 0.176663232013751 0.792066160890498 0.525770012652505 0.511786724054281 0.939086342216131 -0.316336867998586 "BRCA1 MUT" "CGP.60474_IC_50" 0.202822919859686 0.674633090364746 1.67839541496599 0.176678647080743 0.792066160890498 1.32403060877346 0.309800457895011 0.89718581932126 1.32180172721648 "NRAS MUT" "A.770041_IC_50" 0.363428633777057 0.787306955898826 0.514589229090905 0.177102142916129 0.793250865471745 0.643960208954827 0.421075794704007 0.922428741067589 0.484711172813794 "PDGFRA MUT" "Lenalidomide_IC_50" 0.0994503952682238 0.5374999166548 0.784850019083972 0.177121547824622 0.793250865471745 0.564494600629436 0.148722758503382 0.831473272394224 0.669684464730649 "RB1 MUT" "AZD7762_IC_50" 0.154785555308742 0.630721638230745 0.353634808175873 0.177453956339458 0.793417535566492 0.267672467074696 0.350011341006668 0.910234471297282 0.234048516951665 "FLT3 MUT" "Methotrexate_IC_50" 0.486686955452145 0.84074437879216 -0.892199508032115 0.177480607508984 0.793417535566492 1.33393204548158 0.108689064071381 0.794511851748756 1.63745005985821 "MAP2K4 MUT" "PAC.1_IC_50" 0.180431131231355 0.658614416960816 -0.648079792416794 0.177590277375682 0.793417535566492 -0.546020583138884 0.181470105954908 0.84916206298285 -0.685333839941977 "SMAD4 MUT" "SB590885_IC_50" 0.263345100933805 0.725551143932877 0.425717595338985 0.177601543431418 0.793417535566492 0.441397318942542 0.899759473696023 0.988704788932507 0.0448034666282565 "JAK2 MUT" "XMD8.85_IC_50" 0.124097262956381 0.584448902818138 1.62152896907215 0.177721794863272 0.793417535566492 1.21852545293294 0.0281584996860822 0.594003885301891 2.80121923033709 "BRCA2 MUT" "QS11_IC_50" 0.505273659112746 0.847679261741881 -0.536092251021604 0.177736626449693 0.793417535566492 -0.801226193264334 0.296721781880514 0.894167310052 -0.827295919277079 "MLLT3 MUT" "Embelin_IC_50" 0.681001956789846 0.909744040049732 0.13082495632066 0.178081841196564 0.793417535566492 0.340102569755128 0.23952400929104 0.875707386589409 0.386551642679157 "RB1 MUT" "CMK_IC_50" 0.283760174629118 0.739564104351618 0.301695155069399 0.178091871038036 0.793417535566492 0.359124508217435 0.733846446877116 0.96672489654949 0.114970216434076 "CCND1 MUT" "BAY.61.3606_IC_50" 0.0156763781154289 0.227586688087166 0.908211787070702 0.178095465660898 0.793417535566492 0.355636798583559 0.435889839982768 0.922569292988365 0.295562079022758 "TET2 MUT" "Nilotinib_IC_50" 0.517559091091673 0.852353345422823 -0.613764031051956 0.178204572089986 0.793417535566492 1.04527108791817 0.281987428454397 0.887872038823822 1.12849794664325 "CDKN2C MUT" "Cytarabine_IC_50" 0.428175229804667 0.820918238409269 0.559860431861802 0.178305439035103 0.793417535566492 0.717610466240108 0.188287028162985 0.851001889249827 0.921151705749993 "NF2 MUT" "AG.014699_IC_50" 0.100660773453512 0.539510156331103 -0.526871231069473 0.178307642243709 0.793417535566492 -0.38432488587151 0.26905325924219 0.878801763637325 -0.349731968649407 "MET MUT" "Sunitinib_IC_50" 0.0878589634469734 0.511142337432447 2.84783767687075 0.178320166759455 0.793417535566492 1.64767004123216 0.107982855576707 0.792785095696032 2.34602313469932 "SMAD4 MUT" "PF.02341066_IC_50" 0.336949800345214 0.774844944812494 0.559260414383563 0.178485736861297 0.793756549356624 0.74376300872854 0.492607488945609 0.933639405738697 0.416188367272572 "MLH1 MUT" "JW.7.52.1_IC_50" 0.215399105140175 0.688608753079032 1.19294008217994 0.179018137335761 0.795412439638454 -0.790132933024978 0.147867051105009 0.831473272394224 1.43439672655348 "PTEN MUT" "AZD6244_IC_50" 0.319044159607832 0.761311064402907 0.297301669704705 0.17903721054355 0.795412439638454 0.37225332604646 0.783642663625981 0.974078058737889 0.0795386828553763 "MYCN MUT" "AZ628_IC_50" 0.160853313862151 0.636336191287136 0.874687141304351 0.179311537034415 0.795496358047908 0.638493513415549 0.273133935217541 0.882167181782537 -0.699528508846771 "HRAS MUT" "Nutlin.3a_IC_50" 0.331661849224683 0.772603259108552 0.813671721021614 0.179323096749734 0.795496358047908 1.03474768206282 0.405673075529273 0.918000323669952 0.673152677168564 "MSH2 MUT" "AMG.706_IC_50" 0.467833891183491 0.831367686108334 0.354220955198645 0.179327302479545 0.795496358047908 0.602750445655305 0.327768106864702 0.902810042912437 0.443383452239111 "CDH1 MUT" "BMS.754807_IC_50" 0.0332966714431357 0.336031521689191 1.64301898219876 0.179414390853503 0.795496358047908 0.876161206295295 0.0395567499389674 0.64992634601437 1.6685002627129 "MSH2 MUT" "BIRB.0796_IC_50" 0.283437761964031 0.739564104351618 0.496012692307688 0.179691659376551 0.796328157147278 0.593354939474053 0.175379993519246 0.846738869764556 0.624142999474868 "STK11 MUT" "CEP.701_IC_50" 0.967800616720403 0.994434372972651 0.016233066702529 0.180092344439947 0.796970812479539 -0.395937444416875 0.497135370166535 0.934008720636554 -0.264555585235953 "FAM123B MUT" "Vinblastine_IC_50" 0.00715169191686122 0.147707385845685 2.40346452000002 0.180224045046613 0.796970812479539 0.866728442978043 0.0914944855785964 0.765124789476003 1.439805797736 "CCND2 MUT" "Bexarotene_IC_50" 0.416607851705526 0.814099702076568 -0.755054264227635 0.180293221398744 0.796970812479539 -1.10265401054259 0.176984785748643 0.848705119996599 -1.46359956661985 "APC MUT" "CCT007093_IC_50" 0.0682088561803171 0.462100070236188 0.35943376777251 0.180295598441919 0.796970812479539 0.279906584756349 0.443882979127224 0.925809648901546 0.185809110151766 "MSH2 MUT" "Nutlin.3a_IC_50" 0.156243624189503 0.63139838220137 -1.00581263961679 0.180340069579481 0.796970812479539 -0.870723442083411 0.284025500628652 0.8879937007725 -0.741531719514819 "MSH2 MUT" "BI.2536_IC_50" 0.36144004711736 0.787160563087525 0.853105608247427 0.18053786919623 0.796970812479539 0.747861196389196 0.548786885319637 0.947060194029534 0.593189056976052 "MET MUT" "GSK269962A_IC_50" 0.541360311188206 0.861616652986104 -1.00147889830509 0.180542242651657 0.796970812479539 -2.03617903082571 0.859834266402186 0.985479880500142 -0.288675936358322 "KDR MUT" "PLX4720_IC_50" 0.157316587218911 0.632778052170647 1.546340302682 0.180554585599463 0.796970812479539 1.29862320240219 0.0852190638632591 0.749680540483183 1.72279067418828 "CDKN2a(p14) MUT" "BMS.509744_IC_50" 0.0328965132272755 0.334655136278848 -0.455487230927832 0.180801688359077 0.796987604293286 0.223053866153266 0.500261584736068 0.934042323734638 -0.161379910735993 "ALK MUT" "BMS.509744_IC_50" 0.24853457208306 0.715413140877926 -1.00510616040956 0.180807552624864 0.796987604293286 -0.873814739216203 0.120465661964703 0.80757178183218 -1.55154799668996 "FBXW7 MUT" "ABT.263_IC_50" 0.0425825555721034 0.371488876263114 -0.959430838507032 0.180827612053932 0.796987604293286 -0.5697187096887 0.500290730963626 0.934042323734638 -0.296341540275814 "CDKN2a(p14) MUT" "AG.014699_IC_50" 0.0620754996166375 0.448539201336004 -0.258289087890179 0.181095816329401 0.797694765514807 -0.168632479260061 0.0338974216346481 0.618827479917328 -0.302303284317528 "RB1 MUT" "AZD.0530_IC_50" 0.0772567942034847 0.486043076549996 0.587237764625725 0.181263428731889 0.797694765514807 0.400935866031702 0.873565947206195 0.98777404048288 0.0585775717884727 "JAK2 MUT" "Vorinostat_IC_50" 0.0997342695605828 0.5374999166548 0.791974690144853 0.181298998977213 0.797694765514807 0.491351881761927 0.1493590592381 0.831473272394224 0.688949268537954 "NOTCH1 MUT" "Lenalidomide_IC_50" 0.112665436257388 0.563938179281427 -0.455586768377262 0.181347340566872 0.797694765514807 0.35087036514203 0.61166999226476 0.949930222127033 0.152042876198218 "MLH1 MUT" "Bortezomib_IC_50" 0.738795169782069 0.929570057037101 0.269090642361111 0.181491126511348 0.797932027003605 -0.885109409247745 0.890844546682922 0.988301482344111 0.106916679297883 "MYCN MUT" "GSK269962A_IC_50" 0.506957442172382 0.847796212975596 -0.347140455486543 0.18164046500696 0.798193453600601 -0.671277102280561 0.636945365002942 0.953101495776253 -0.292519241932152 "EGFR MUT" "Z.LLNle.CHO_IC_50" 0.525557794712236 0.854969048950887 -0.37064282167832 0.182106633480619 0.799418926973694 -0.71055969565195 0.711957094266554 0.962630898212352 -0.212213603848229 "BRCA1 MUT" "BMS.708163_IC_50" 0.126838759295456 0.587206821914858 0.929481890134542 0.182162149923332 0.799418926973694 0.821278588166893 0.120848310818964 0.808173078601819 0.951208627340011 "MYC MUT" "Docetaxel_IC_50" 0.538869655753534 0.861419263046422 -0.184895257103258 0.182189758126652 0.799418926973694 -0.30226991457342 0.548714007642971 0.947060194029534 -0.182322143185045 "SMAD4 MUT" "PLX4720_IC_50" 0.162389998186418 0.637610023074489 0.530759699244638 0.182414983668872 0.799418926973694 0.461956725264773 0.63341608776826 0.952523560833852 0.175045596473106 "MLL_AFF1 MUT" "NSC.87877_IC_50" 0.204415567648264 0.676208608713317 1.00560155172414 0.182641964424157 0.799418926973694 1.05548654720978 0.352401573380542 0.91110953125066 0.752766274988808 "CDH1 MUT" "CCT018159_IC_50" 0.273549897148466 0.734000646544246 -0.636239708141334 0.182696975277773 0.799418926973694 -0.72593957258681 0.188738406056581 0.851001889249827 -0.858569154001244 "CDKN2C MUT" "Doxorubicin_IC_50" 0.111657618326921 0.563072279454009 0.988491813227509 0.18281560478598 0.799418926973694 0.514348275791805 0.573959772459828 0.949294892873838 0.397241263561179 "PIK3CA MUT" "AUY922_IC_50" 0.972021926302987 0.995220468612913 -0.00949265129948324 0.182890159726001 0.799418926973694 0.244205711054988 0.849782126679031 0.984337428855677 -0.0537534585295901 "MYCL1 MUT" "NSC.87877_IC_50" 0.248205571405624 0.715413140877926 0.41209657342657 0.183026888885633 0.799418926973694 0.466929556795143 0.443224672352725 0.925809648901546 0.303374741025412 "MLLT3 MUT" "Axitinib_IC_50" 0.296023333590655 0.747305163324792 0.433992978121771 0.183232724273781 0.799418926973694 0.46503142960118 0.229829377974999 0.868190006718827 0.458937885854942 "MET MUT" "Paclitaxel_IC_50" 0.918602488639407 0.985397838097183 0.188842572881355 0.183276309536744 0.799418926973694 -1.05990542498753 0.752940475377945 0.968780465757047 0.581395501908326 "ALK MUT" "AZD.0530_IC_50" 0.507408960455471 0.847796212975596 -0.674446310169492 0.183433105900725 0.799418926973694 -1.18014318502433 0.118442354762915 0.806524749270063 -1.74511050454179 "APC MUT" "GNF.2_IC_50" 0.069345769862847 0.466280108629924 -0.697717353429019 0.183438623122418 0.799418926973694 -0.504609891233733 0.124906237333724 0.817150972850516 -0.710753197572346 "BRCA2 MUT" "BAY.61.3606_IC_50" 0.596027395693278 0.879149639202396 -0.415833673963809 0.183495823360194 0.799418926973694 -0.729050872640343 0.130458947782606 0.824553892801908 -1.12372998082576 "PTEN MUT" "BMS.509744_IC_50" 0.0917740754031968 0.51814721147857 0.459315517068274 0.183669016662235 0.799418926973694 0.273524214308655 0.0713439890377618 0.730928846615752 0.520890745682279 "FAM123B MUT" "Pazopanib_IC_50" 0.13826513763743 0.606087209949663 1.25330816958044 0.183705361173823 0.799418926973694 0.955897197252031 0.220953873615174 0.864815645798718 0.958543321156385 "FBXW7 MUT" "Sunitinib_IC_50" 0.400006068952386 0.805918367644724 -0.671250788617882 0.183740171125417 0.799418926973694 0.793125660416432 0.958358369531213 0.99641548698706 0.0374127155185678 "MSH2 MUT" "CMK_IC_50" 0.183435702962368 0.660385845878234 1.02323829553265 0.183834786433636 0.799418926973694 0.934378983607584 0.301805478574994 0.894167310052 0.82521103986152 "MS-HL MUT" "Lapatinib_IC_50" 0.118192804377312 0.575477135786684 0.488585713831476 0.183901362603233 0.799418926973694 0.363423896140703 0.735834360898483 0.96672489654949 0.103567505329529 "ALK MUT" "SB.216763_IC_50" 0.0906778515765834 0.515893657816551 -1.74192970760234 0.183955673883404 0.799418926973694 -1.32103735391697 0.172075443002776 0.842832361237713 -1.36596359198988 "PDGFRA MUT" "Methotrexate_IC_50" 0.673352804148872 0.908308454633653 -0.419735977822585 0.183961066311621 0.799418926973694 -1.00592379490603 0.0784859138313997 0.741811190933953 -1.40804281452547 "MSH6 MUT" "Rapamycin_IC_50" 0.439377263744055 0.824500931653809 1.17362719256758 0.184018021232053 0.799418926973694 1.73038034352897 0.521775649042482 0.939635632721979 0.979356350850176 "MLL_AFF1 MUT" "X17.AAG_IC_50" 0.0912489539358594 0.516507787943737 2.62256477142864 0.184038397853642 0.799418926973694 1.83958371393611 0.395037488146658 0.916003810456352 1.17524557218453 "CDH1 MUT" "JNJ.26854165_IC_50" 0.0508510160798072 0.402144144082607 0.845636099773253 0.18416589359858 0.799418926973694 0.542603402029396 0.132708038219752 0.825803094910049 0.673569558495116 "MYCL1 MUT" "RO.3306_IC_50" 0.359696635845125 0.786601117838604 -0.51213905888982 0.184169702126808 0.799418926973694 -0.70590356733293 0.377642203503294 0.914419412871569 -0.542314326188986 "TSC1 MUT" "ABT.888_IC_50" 0.894920000200779 0.976746285090711 0.0989304304761931 0.184546380493039 0.799987950410793 0.839485996455029 0.297232397926154 0.894167310052 0.728925759803261 "MDM2 MUT" "SL.0101.1_IC_50" 0.0501523234828961 0.398392473033632 0.759708518518512 0.184560288314761 0.799987950410793 0.449526574493818 0.0534588628202206 0.696596443061099 0.715620326247495 "NRAS MUT" "Salubrinal_IC_50" 0.103800292961111 0.546119906272292 -0.618698185148186 0.184579444919612 0.799987950410793 -0.433786588519511 0.189417834600207 0.851001889249827 -0.55757558981963 "KRAS MUT" "CCT007093_IC_50" 0.0325718120209338 0.333260671149669 0.268638833746897 0.184661107796659 0.799987950410793 0.177908212770243 0.466715535715608 0.929276781658587 0.107822792505221 "FLT3 MUT" "CHIR.99021_IC_50" 0.107922926878347 0.552948315127282 -1.15597624567474 0.184826017729866 0.800311976332981 -0.913744336828189 0.0420055469801891 0.658180729724545 -1.41934431244155 "SMARCA4 MUT" "MS.275_IC_50" 0.291208329710388 0.746581806188469 1.34236742123286 0.184920544492483 0.800331069998898 1.39893263276448 0.84810217622224 0.98378870157398 -0.435053090671828 "CCND2 MUT" "JNJ.26854165_IC_50" 0.206501746821166 0.679262390469222 1.01895049327353 0.185038849892253 0.800349707999089 0.989992259019959 0.524605050481149 0.940554660491705 0.486231733100367 "MAP2K4 MUT" "NVP.TAE684_IC_50" 0.280209099134939 0.737882141891724 -1.53682352188552 0.185272978297267 0.800349707999089 -1.54630730005953 0.323784795824334 0.900918773778407 -1.71470917068107 "CDKN2a(p14) MUT" "Cytarabine_IC_50" 0.000142559088550463 0.0123047121076041 -0.670735639688743 0.185528670221611 0.800349707999089 -0.185115839334748 0.172628314952303 0.842832361237713 -0.24996927522966 "PIK3R1 MUT" "GDC0941_IC_50" 0.188126069303071 0.663245512002727 0.851398007276503 0.185704385404471 0.800349707999089 0.688408481517704 0.262467762055356 0.877052916121269 0.717314185947174 "MS-HL MUT" "Temsirolimus_IC_50" 0.667411662116941 0.905896831921222 0.131537739253354 0.185728294757901 0.800349707999089 0.310608862984648 0.829031364013876 0.981081757090089 0.0685944303973371 "VHL MUT" "PHA.665752_IC_50" 0.231830401435551 0.704757001699372 -0.738063288135591 0.18578842120812 0.800349707999089 -0.820884872704396 0.430251640250363 0.922428741067589 -0.583604479657305 "APC MUT" "JNK.9L_IC_50" 0.736079448812167 0.928872455997232 -0.0841801776136365 0.186012788087662 0.800349707999089 -0.267370141089039 0.3946402478175 0.915926348152589 -0.257411986048051 "CTNNB1 MUT" "VX.680_IC_50" 0.240736974607954 0.711340033600749 -1.27068229080461 0.186063365954457 0.800349707999089 -0.923740979839317 0.251581084630564 0.875707386589409 -1.42526413140821 "MLH1 MUT" "CEP.701_IC_50" 0.532024918504917 0.857771840823296 -0.351537801333798 0.186084193941118 0.800349707999089 -0.551277785122288 0.674152799974389 0.960256725054738 0.216389167054523 "CDKN2C MUT" "GSK269962A_IC_50" 0.368880203536998 0.789246419666677 0.856190171821311 0.186152456221583 0.800349707999089 1.17933667843686 0.0852479100421234 0.749680540483183 1.97883282292394 "CDKN2a(p14) MUT" "Cyclopamine_IC_50" 0.00900161785046317 0.166544702234212 -0.480079351063829 0.186177420448494 0.800349707999089 -0.241916825451219 0.295289234133451 0.894167310052 -0.220643614962252 "JAK2 MUT" "MG.132_IC_50" 0.297845238159828 0.748701828501963 -1.42705125423729 0.186227602851102 0.800349707999089 -1.58514346070563 0.989938913012991 0.998596943033664 -0.0198622028940177 "BCR_ABL MUT" "Tipifarnib_IC_50" 0.758227772269172 0.934762260113025 -0.345733850785346 0.186373458492373 0.800349707999089 -1.18443641418394 0.539181458813654 0.944569766818715 0.692004314748208 "EP300 MUT" "Cytarabine_IC_50" 0.773890084975513 0.94153218611416 0.330007565272492 0.186422977366485 0.800349707999089 1.15397666168485 0.748555687832783 0.968780465757047 0.338899665201065 "APC MUT" "Bortezomib_IC_50" 0.0658110398781619 0.457742485196035 -1.26920058851673 0.186545870523072 0.800349707999089 -0.768910912052513 0.0387191281347388 0.646945958867072 -1.62307468144953 "NRAS MUT" "ABT.263_IC_50" 0.0964278372246919 0.530263543277083 -0.649956894789894 0.18656199521606 0.800349707999089 -0.482085781119291 0.700838491821194 0.961100601384891 -0.149619223760457 "JAK2 MUT" "Shikonin_IC_50" 0.0366723979841711 0.350045952014557 1.62222225540377 0.186760973433487 0.800349707999089 0.863364250753114 0.0354172359674495 0.624088239339126 1.73252116239631 "CCND2 MUT" "FH535_IC_50" 0.41757153093033 0.814099702076568 -0.745822332752605 0.18677157471952 0.800349707999089 -1.0340868016752 0.0497078611924101 0.679896345274018 -2.10840192155172 "KIT MUT" "Obatoclax.Mesylate_IC_50" 0.737898118766266 0.929570057037101 0.346173674475526 0.186780168007717 0.800349707999089 1.00350942101626 0.822908418926506 0.977953923255225 0.222560587653713 "KDM5C MUT" "BI.2536_IC_50" 0.177549999946111 0.656513564381252 -1.53710814163823 0.186904152616601 0.800349707999089 -0.893559030311107 0.227829819386535 0.867648638924452 -1.41952881817541 "BRCA1 MUT" "NU.7441_IC_50" 0.451741266338809 0.828509891052426 -0.540301932673265 0.187091122527247 0.800349707999089 -0.832492613163821 0.262365150181707 0.877052916121269 -0.772057679382829 "CDKN2a(p14) MUT" "Temsirolimus_IC_50" 0.0153151324371215 0.225561676905598 -0.49352049709329 0.187125425185931 0.800349707999089 -0.213722284537929 0.480629711729859 0.930304161706959 -0.152461306440078 "CDK6 MUT" "NVP.TAE684_IC_50" 0.954040676884447 0.992679871625456 -0.0821029831649828 0.187258819608136 0.800349707999089 -1.547626989146 0.12892207774068 0.820169751013594 2.64791227222568 "FGFR2 MUT" "Lenalidomide_IC_50" 0.287227193242888 0.742393685445311 0.799916034155595 0.187267675629328 0.800349707999089 0.876103784523289 0.614901988996835 0.950059945073224 0.511676458236484 "TET2 MUT" "Cytarabine_IC_50" 0.0345651133451221 0.342986337003385 -2.42261611026612 0.187271080477093 0.800349707999089 -1.16015537067033 0.416427549016418 0.922398153848459 -1.06265781347805 "KRAS MUT" "A.770041_IC_50" 0.71729128515578 0.921306561002511 0.200987308632179 0.187374660443292 0.800349707999089 0.6287130827353 0.255532123270219 0.875707386589409 0.65646350162502 "FLCN MUT" "AS601245_IC_50" 0.0226541268346184 0.275471947213824 1.8399733006993 0.187422754920971 0.800349707999089 0.85227709738572 0.0159982760125154 0.507431033096963 2.46958321642601 "MLLT3 MUT" "WO2009093972_IC_50" 0.173565615654048 0.65113493295882 -0.550628741092639 0.18747842998318 0.800349707999089 -0.476457706074465 0.212901461521916 0.857926079659413 -0.510670698600337 "FBXW7 MUT" "Gemcitabine_IC_50" 0.812886317693632 0.953790908632203 -0.208536495004095 0.187553654536791 0.800349707999089 0.783434995345882 0.469808247977478 0.929276781658587 0.620261770452894 "MLLT3 MUT" "AUY922_IC_50" 0.094963880389888 0.527890690029858 -0.702025422833168 0.187701617737933 0.800349707999089 -0.370234104901653 0.249908372121529 0.875707386589409 -0.483097377728971 "MAP2K4 MUT" "KIN001.135_IC_50" 0.228171823971127 0.700674643726675 0.470861779661015 0.187805332968655 0.800349707999089 0.505964731648484 0.244044991235156 0.875707386589409 0.497069631612674 "KDR MUT" "Nilotinib_IC_50" 0.368821313645523 0.789246419666677 -0.85221296007605 0.187953516248561 0.800349707999089 -1.0083042747169 0.367790053384407 0.913948248824328 -0.776216058224836 "TP53 MUT" "Vinorelbine_IC_50" 0.343970562521681 0.780249349533262 -0.168003031881148 0.188066520121686 0.800349707999089 -0.176527388360075 0.561322097392489 0.949294892873838 -0.109366084028051 "KIT MUT" "AICAR_IC_50" 0.435016115573253 0.823150425912549 0.67180165048543 0.188084748338024 0.800349707999089 1.01520485749934 0.850549189697783 0.984453468864253 0.1569822838963 "KRAS MUT" "PF.02341066_IC_50" 0.365306383704626 0.787984332414431 0.319308655313138 0.18819264838817 0.800349707999089 0.453127315437577 0.234169745763573 0.869962136993019 0.447276485212266 "CDH1 MUT" "EHT.1864_IC_50" 0.123660528448914 0.583699714338599 -0.740840599806525 0.188442636668177 0.800349707999089 -0.63422935929156 0.30019837795181 0.894167310052 -0.529705506362981 "IDH1 MUT" "JNJ.26854165_IC_50" 0.0862492792810872 0.506600429428132 -1.38272125560537 0.188525648082585 0.800349707999089 -0.982794703008366 0.158020909226787 0.83854630828105 -1.08456496869828 "MS-HL MUT" "PD.0325901_IC_50" 0.106597125445133 0.551362301152142 0.497825069463084 0.188532604915061 0.800349707999089 0.381463619519559 0.0555229262869901 0.697813103075383 0.565076449026501 "RB1 MUT" "Bexarotene_IC_50" 0.0182209641655874 0.247069557579196 0.494846697533061 0.188541386883663 0.800349707999089 0.252404468354461 0.408745683576799 0.920903133902018 0.188107575749453 "SETD2 MUT" "PD.173074_IC_50" 0.241913826626551 0.711340033600749 1.19356425781248 0.188552570364916 0.800349707999089 1.15665813062746 0.333186548779536 0.903569160603576 0.908359500456725 "MAP2K4 MUT" "WH.4.023_IC_50" 0.495308203421616 0.843282996121548 1.40465380887372 0.188818733672451 0.800349707999089 2.35262013629996 0.396455357654873 0.916480913435499 1.98624365147749 "BCR_ABL MUT" "Thapsigargin_IC_50" 0.878198808930735 0.971802715567801 -0.221269143106461 0.188843866924211 0.800349707999089 -1.74312561567312 0.98537805464824 0.998124818853736 0.0262194493641932 "APC MUT" "PAC.1_IC_50" 0.366125318496382 0.788563052166059 -0.287924283705538 0.188917213261978 0.800349707999089 -0.364927018878775 0.606531714759452 0.949657634568742 -0.192654101615305 "SMO MUT" "NSC.87877_IC_50" 0.108099375140165 0.553331729463865 -1.27267758620692 0.189006096151933 0.800349707999089 -1.01834800339245 0.11353555214982 0.799692247086917 -1.26657265028379 "CCND1 MUT" "Sorafenib_IC_50" 0.829372384284137 0.958015830101332 -0.128264944250872 0.189162895877773 0.800349707999089 -0.755770685266695 0.623928466482761 0.950496524771391 -0.356601944564829 "FGFR3 MUT" "Epothilone.B_IC_50" 0.67023504303763 0.906882709825482 -0.575323016260156 0.189224079136619 0.800349707999089 1.00879936766128 0.647604662964917 0.957449344088104 -0.600714352745735 "PIK3CA MUT" "AZD8055_IC_50" 0.996598175293975 0.998977896287767 -0.000926859528214873 0.189234591575947 0.800349707999089 -0.225451203999525 0.714777117827076 0.962630898212352 -0.0841326398095708 "EWS_FLI1 MUT" "NU.7441_IC_50" 0.705724652123029 0.916395127621392 -0.146405677344876 0.189306884542016 0.800349707999089 0.476783487169351 0.272990991207725 0.882167181782537 0.477984409820806 "ALK MUT" "ZM.447439_IC_50" 0.0570779178605929 0.429883025426179 -1.75775812981084 0.189533202656433 0.800349707999089 -0.967084582443742 0.149893866543546 0.831473272394224 -1.54742694366458 "RUNX1 MUT" "Nilotinib_IC_50" 0.317658237139139 0.761258739353268 0.94752348479087 0.189564420760661 0.800349707999089 1.00449763224389 0.486906027656391 0.933639405738697 0.588344215124814 "MLH1 MUT" "ABT.263_IC_50" 0.888977071897492 0.975527896272722 0.0925668890294615 0.189620984335618 0.800349707999089 0.794949607868568 0.131479894606848 0.824721122422311 0.875381646926745 "MYC MUT" "TW.37_IC_50" 0.0829163943002619 0.498552626562699 -0.422490383497626 0.189698298524334 0.800349707999089 -0.290180399478241 0.0262944348233378 0.585472903331568 -0.547046973846703 "BCR_ABL MUT" "Pyrimethamine_IC_50" 0.039902375032104 0.361141839503332 -2.39627863481227 0.189751470579024 0.800349707999089 -1.6408963212686 0.251259025449221 0.875707386589409 -1.36840676456249 "SMO MUT" "Gefitinib_IC_50" 0.350094387067087 0.784966682190403 -1.07440626944971 0.189825166070096 0.800349707999089 -1.34956976703146 0.420144011392419 0.922428741067589 -0.831791851950865 "KDR MUT" "X681640_IC_50" 0.272322473862801 0.734000646544246 1.03616754471546 0.190005225686703 0.800349707999089 1.05685761413983 0.641503340093843 0.955103296458244 0.417212243105564 "KIT MUT" "X681640_IC_50" 0.272322473862801 0.734000646544246 1.03616754471546 0.190005225686703 0.800349707999089 1.05685761413983 0.641503340093843 0.955103296458244 0.417212243105564 "MLLT3 MUT" "RO.3306_IC_50" 0.19803472597321 0.674012093366938 0.453584153225808 0.190155902051041 0.800349707999089 0.439471633997135 0.261552604601561 0.877052916121269 0.415755673695515 "SETD2 MUT" "AKT.inhibitor.VIII_IC_50" 0.116171598197103 0.570433713690719 -1.78013364310349 0.190259220801526 0.800349707999089 -1.27984133268634 0.188498252113637 0.851001889249827 -1.4571991191938 "RB1 MUT" "Cisplatin_IC_50" 0.311311145710458 0.758106606660947 -0.23351530807526 0.190369286408181 0.800349707999089 -0.267733932098775 0.0537431277517927 0.697305726351784 -0.470732028842018 "HRAS MUT" "ATRA_IC_50" 0.0679428414896976 0.461747350209541 1.2908687275641 0.190402043071064 0.800349707999089 0.731819948622789 0.188672081398356 0.851001889249827 0.815372607996047 "MLLT3 MUT" "EHT.1864_IC_50" 0.261247686484639 0.724288808298587 -0.361482517281108 0.190478904913578 0.800349707999089 -0.417640559539211 0.0856315511976769 0.74999389170273 -0.55035428570448 "CTNNB1 MUT" "Vorinostat_IC_50" 0.493810332637693 0.843282996121548 -0.263955845873563 0.190512248925805 0.800349707999089 -0.386047013347325 0.141566219873499 0.831473272394224 -0.542713961926072 "BCR_ABL MUT" "SL.0101.1_IC_50" 0.0006180222922374 0.0334674144960997 -2.07956233140659 0.190978792662081 0.800956157148384 -0.846364271002929 0.0327836796416415 0.618827479917328 -1.2901992844816 "MYCN MUT" "KU.55933_IC_50" 0.431918897016055 0.821209960265379 0.219776795472286 0.191025862074698 0.800956157148384 0.338263338035405 0.674046257736042 0.960256725054738 0.143741265304126 "EGFR MUT" "MK.2206_IC_50" 0.185733761699683 0.661122860783523 0.53901974411135 0.191046519520911 0.800956157148384 0.428151313479788 0.315997128277074 0.900294798053993 0.420046356365455 "BRAF MUT" "MK.2206_IC_50" 0.0217803512402997 0.269402923906827 0.632936846692307 0.191054849024828 0.800956157148384 0.304849509103884 0.728534039689379 0.965402608571648 0.10953807130067 "EP300 MUT" "Sorafenib_IC_50" 0.235579534393714 0.708702464036204 1.55519644406778 0.191107543857384 0.800956157148384 1.63081745093045 0.265901769786462 0.877052916121269 1.50330812222858 "CDH1 MUT" "AP.24534_IC_50" 0.032683575878102 0.333904808801746 1.98222715532287 0.191344799633643 0.801572247899238 1.10800070352882 0.115954067881704 0.802355750183445 1.47013835971905 "KDM5C MUT" "NU.7441_IC_50" 0.234041905379995 0.707628390886945 -0.985212699604754 0.191514538222034 0.801905051367225 -0.947827917415947 0.196877177431234 0.851001889249827 -1.02253208272779 "CDK6 MUT" "PF.4708671_IC_50" 0.100000562137492 0.53759382103091 -0.688448750000001 0.1916263744324 0.801995207980274 -0.537436589247031 0.0635963982076164 0.70501719149803 -0.783561633142323 "CDKN2a(p14) MUT" "Obatoclax.Mesylate_IC_50" 0.248417885748574 0.715413140877926 -0.230603779031204 0.191896827855013 0.802748812143367 0.200688941990378 0.284401242290522 0.8879937007725 0.228966474618691 "ERBB2 MUT" "JNJ.26854165_IC_50" 0.835959090290025 0.959122768755193 0.0600525925925934 0.192064846956012 0.803073401985095 -0.366853810950346 0.0798551287571948 0.741811190933953 -0.511918819337126 "NF2 MUT" "PF.562271_IC_50" 0.102852410023775 0.543688489044222 -0.555802273236567 0.192178009921995 0.803168426408112 -0.363400805169354 0.692638219678473 0.961100601384891 -0.14264460251109 "CDKN2a(p14) MUT" "PF.02341066_IC_50" 0.00628102195392591 0.137732730797076 -0.546698496936277 0.192429110397821 0.803277936968256 -0.254720580298995 0.124919084316818 0.817150972850516 -0.343534447045378 "CDKN2C MUT" "RO.3306_IC_50" 0.145384786328315 0.619919550890177 -0.761815923913037 0.192429322179375 0.803277936968256 -0.652484000221359 0.0694042678400398 0.723529520383236 -1.01619971833826 "SMAD4 MUT" "VX.680_IC_50" 0.013064791466298 0.207480784061478 -2.48311222787938 0.192630159182025 0.803277936968256 -0.883343862797531 0.0337068977752657 0.618827479917328 -2.32176886268067 "SETD2 MUT" "CMK_IC_50" 0.141625734308107 0.613849754216838 1.77782620408164 0.192654816094463 0.803277936968256 1.4778480389306 0.0509310853849603 0.689395114310948 2.43767164107861 "AKT2 MUT" "NVP.BEZ235_IC_50" 0.167151351310798 0.646614658212831 0.957196326000009 0.192656458252718 0.803277936968256 0.65159727347979 0.132783112209385 0.825803094910049 0.997894529158341 "EWS_FLI1 MUT" "CGP.082996_IC_50" 0.129384028013899 0.591080016868021 0.76075766826155 0.193011661872961 0.803347250506102 0.598100893387778 0.287703047782185 0.888563331668781 0.607999670338338 "KDM5C MUT" "Rapamycin_IC_50" 0.442098231780839 0.825166478070376 1.16666688851353 0.193067936965349 0.803347250506102 1.70253735266788 0.413194530820774 0.921714070263062 1.25372567272037 "CTNNB1 MUT" "Docetaxel_IC_50" 0.838892731435675 0.959212868273494 -0.107324577427823 0.193129073881439 0.803347250506102 0.516588083908033 0.333759702238122 0.903569160603576 -0.538844124207907 "NF2 MUT" "Paclitaxel_IC_50" 0.605875732432236 0.882603260686518 -0.432203397212545 0.193142259140078 0.803347250506102 0.48130236012901 0.808493509250249 0.977383317127464 0.222273329792831 "MDM2 MUT" "MG.132_IC_50" 0.85107484047314 0.963639744191413 0.200204163822526 0.193214613331597 0.803347250506102 1.22366345987502 0.367270497865148 0.913948248824328 0.894370419105252 "CCND1 MUT" "WO2009093972_IC_50" 0.401513739401107 0.806415132522709 0.261438590619138 0.19321582333983 0.803347250506102 0.368978115594209 0.581070462515101 0.949294892873838 0.183657331365377 "CDKN2C MUT" "PAC.1_IC_50" 0.0260791836682584 0.300011956162957 1.22255517460317 0.193326757240973 0.803432349582161 0.601751474352292 0.0957565510901273 0.77097828178369 1.0539899639533 "BCR_ABL MUT" "Etoposide_IC_50" 0.808711151012827 0.952641225877339 -0.297486373702419 0.193691848392923 0.803812298205408 -1.25308140351102 0.36944222345915 0.913948248824328 1.06444484133396 "ALK MUT" "BX.795_IC_50" 0.0521417848158075 0.407137850996674 -1.7931800649087 0.193836437801607 0.803812298205408 -0.92811815898692 0.0434717454793229 0.659657620288543 -2.02333124048106 "KDM6A MUT" "KIN001.135_IC_50" 0.269305735560646 0.732006752858616 0.243208041958044 0.193918914112734 0.803812298205408 0.279737489972366 0.616350112473104 0.950247055931602 0.11376362841151 "RB1 MUT" "PF.4708671_IC_50" 0.600771157893341 0.880741900288913 0.104248324775353 0.193929646609367 0.803812298205408 0.260613065097874 0.311423381703205 0.898149383211927 0.222009714275498 "FGFR3 MUT" "AZD.2281_IC_50" 0.329524678935447 0.770742342276984 -1.03399054133856 0.193930358177861 0.803812298205408 -1.03950064051172 0.0635047539194636 0.70501719149803 -1.72243533526257 "MYC MUT" "PF.02341066_IC_50" 0.078465641257391 0.486980385654137 0.607519170289858 0.194110579435778 0.803812298205408 0.426238748778384 0.350604971181196 0.910340341961272 0.335555437613088 "PDGFRA MUT" "ABT.888_IC_50" 0.149728800624317 0.62466549367193 0.68367142911877 0.194123247098531 0.803812298205408 0.519892484667192 0.33246840525403 0.903405836635744 0.437092829841574 "KDM5C MUT" "WH.4.023_IC_50" 0.522493253351823 0.853303159804623 1.14286152739726 0.194236819299001 0.803812298205408 2.02792177910875 0.415536801948242 0.92211126027385 1.35319824487034 "KRAS MUT" "Pazopanib_IC_50" 0.0185802721542546 0.248885968328711 0.527530165213101 0.194326528557485 0.803812298205408 0.261664647698037 0.218187554053438 0.860928912580141 0.288799740210747 "MLL_AFF1 MUT" "DMOG_IC_50" 0.0291840778456457 0.316210068663154 -2.75949137931035 0.194329189578029 0.803812298205408 -1.50430495513105 0.154326375648735 0.835611501078903 -1.71291812474942 "SMO MUT" "CI.1040_IC_50" 0.149818432780229 0.62466549367193 1.82269608587789 0.194413784094721 0.803812298205408 1.46154695675981 0.23997045007647 0.875707386589409 1.30608489491988 "MSH2 MUT" "Obatoclax.Mesylate_IC_50" 0.0627282365788183 0.450355270053747 -1.62762654285716 0.194670329186866 0.804201098908206 -0.839626827820316 0.0688553732184024 0.722654662887059 -1.54091900516213 "PIK3CA MUT" "Thapsigargin_IC_50" 0.675784303272893 0.908552538148308 0.172008770766944 0.194688927221331 0.804201098908206 0.410844291651575 0.699434927008948 0.961100601384891 -0.16935037635106 "BRCA1 MUT" "ABT.263_IC_50" 0.569250908315208 0.872389778906173 -0.621449066666669 0.194861711600502 0.804540614004676 -1.2756248551824 0.455097016088114 0.925809648901546 -0.704837174561802 "CDKN2C MUT" "GNF.2_IC_50" 0.312401997811765 0.759215564942334 0.521935035632185 0.195096585866371 0.805136049758011 0.638686829765513 0.256569149859885 0.875707386589409 0.723676306391877 "MYC MUT" "Bosutinib_IC_50" 0.156409913392975 0.63139838220137 0.418554897843937 0.195258720478603 0.805430885541323 0.315491340380053 0.128879414486642 0.820169751013594 0.434230800876632 "SETD2 MUT" "CGP.60474_IC_50" 0.525937534855854 0.854969048950887 -0.836698462585036 0.195471154353528 0.805932832782582 -1.28763332862727 0.946012436501496 0.995668765770473 0.0879276264888141 "NF1 MUT" "PLX4720_IC_50" 0.0573371808448322 0.430077283009252 0.764846412090772 0.195572354432264 0.805975907059369 0.464700298986801 0.320715409340031 0.900918773778407 0.3933312690981 "MET MUT" "CCT007093_IC_50" 0.2146561585504 0.688117861819268 0.401189318181819 0.195781211844041 0.806070936491907 0.418531716843469 0.284934274459265 0.8879937007725 0.348487254962043 "KDM6A MUT" "JNK.9L_IC_50" 0.295046626344004 0.747036827777118 -0.319515065189714 0.195943697886551 0.806070936491907 -0.310238348747756 0.643363406029964 0.955972780483685 -0.148459308837871 "CDKN2C MUT" "Midostaurin_IC_50" 0.794237716111563 0.948646027682356 -0.155445082167832 0.196047465886209 0.806070936491907 -0.595719373076175 0.766979432514902 0.969901216545994 -0.191589668573646 "RB1 MUT" "EHT.1864_IC_50" 0.434979049724538 0.823150425912549 0.167356106285131 0.196269969352846 0.806070936491907 0.280410491179521 0.211018578884835 0.855272470862467 0.282776287413555 "ERBB2 MUT" "Roscovitine_IC_50" 0.38592752434093 0.798746759187088 0.729604861111111 0.196337557665675 0.806070936491907 0.97877778720996 0.10689203093736 0.792410790279379 1.40550600875425 "EP300 MUT" "NVP.BEZ235_IC_50" 0.683899834515541 0.910554660150617 0.363799654050467 0.196416723844207 0.806070936491907 0.836804782356188 0.450786973086379 0.925809648901546 0.63572692102677 "CDK4 MUT" "AMG.706_IC_50" 0.108855568830575 0.555860688046234 0.655794146825398 0.196469372546419 0.806070936491907 0.487989401557584 0.0882012045662339 0.756825988166882 0.673479884679953 "KIT MUT" "Bicalutamide_IC_50" 0.514179349201183 0.85130999259055 0.181730874125876 0.196519510689426 0.806070936491907 0.343146920253803 0.219085256533818 0.861955336129779 0.321309433194611 "MLLT3 MUT" "BMS.754807_IC_50" 0.146248919943773 0.619919550890177 -0.742874122730393 0.196553481499094 0.806070936491907 -0.549522591438726 0.268750649963686 0.878136321680462 -0.579569538031005 "NF2 MUT" "Bexarotene_IC_50" 0.0407074769735447 0.364438611897228 -0.729398895255231 0.196563802847178 0.806070936491907 -0.414467863503309 0.383227951179953 0.915134825237766 -0.320525509961341 "AKT2 MUT" "BMS.708163_IC_50" 0.289426153769731 0.745041643950428 0.577921175280902 0.196598382460866 0.806070936491907 0.706412179056052 0.354834289986763 0.91161229252998 0.513701037702446 "CCND2 MUT" "AUY922_IC_50" 0.246561045395409 0.714668105985286 1.26936184030196 0.196746483766171 0.806070936491907 0.944543214994859 0.678084656464107 0.961070832119013 -0.531033208387582 "MS-HL MUT" "Erlotinib_IC_50" 0.0448985662929175 0.378674422837037 0.614011098432455 0.196775339524204 0.806070936491907 0.361605702577659 0.157939674452405 0.83854630828105 0.473600010042766 "SMAD4 MUT" "Vinorelbine_IC_50" 0.312692860583238 0.759215564942334 -0.389266255222301 0.197014985392635 0.806501117461558 -0.374688244098981 0.222479799089841 0.865601665610206 -0.496368121748764 "KDM6A MUT" "AZD.0530_IC_50" 0.026719382208786 0.30299183543909 -1.14645553312721 0.197061977805605 0.806501117461558 -0.57984023162874 0.011106001600146 0.450437967177441 -1.34370059702412 "KIT MUT" "OSI.906_IC_50" 0.30450577260136 0.754155959782231 0.939653486013992 0.197302676882106 0.807114266877007 1.11745046365708 0.393962477430084 0.915926348152589 0.785237571841241 "NF1 MUT" "AUY922_IC_50" 0.0172229901133404 0.240182256337938 0.957423781117568 0.197592756428783 0.807635512162703 0.351410051938569 0.068921123687123 0.722654662887059 0.756556107794372 "PTEN MUT" "X681640_IC_50" 0.639657092596418 0.895624997957207 0.0984833458823526 0.19785559782414 0.807635512162703 0.236004584772044 0.731153291292448 0.96639568318693 0.0742746067236464 "RUNX1 MUT" "ZM.447439_IC_50" 0.177637889337704 0.656513564381252 -1.24646056947163 0.197900284644826 0.807635512162703 -0.942789994199323 0.110970953566439 0.797376436030023 -1.37991291914956 "CDK4 MUT" "DMOG_IC_50" 0.321599169345566 0.762445868381734 -0.631336759581883 0.19792905001532 0.807635512162703 -0.74129183248947 0.365656617823186 0.913948248824328 -0.577021248782471 "PIK3CA MUT" "BMS.509744_IC_50" 0.148522929820541 0.623066669691177 0.708582559588299 0.197963838986463 0.807635512162703 0.47012148014881 0.524949385732242 0.940554660491705 0.336298823858259 "MLH1 MUT" "Etoposide_IC_50" 0.232182954444388 0.704757001699372 -0.853060843859651 0.198070454071111 0.807635512162703 -0.602996185593695 0.619652659976369 0.950496524771391 -0.33808480225806 "CDKN2C MUT" "FH535_IC_50" 0.191277485994453 0.666693623672188 0.662285511463842 0.198094200793769 0.807635512162703 0.561299610805387 0.359115247937003 0.91161229252998 0.531148513247445 "CCND1 MUT" "Paclitaxel_IC_50" 0.572492480534038 0.872392882570829 -0.433059792982456 0.198157615246316 0.807635512162703 -0.43490182518237 0.862199794548587 0.985735887665551 0.154693167332388 "CCND2 MUT" "PAC.1_IC_50" 0.40706370171669 0.809352267869285 -0.828142054587679 0.198346548517828 0.808034723571939 -1.06900704562314 0.462755077934553 0.929276781658587 -0.864076793274354 "SETD2 MUT" "BI.2536_IC_50" 0.173100128317932 0.65113493295882 2.18879803220339 0.198709117914936 0.808356400049876 1.23981281009005 0.101299838962321 0.774414870229822 2.75346103621143 "KRAS MUT" "Imatinib_IC_50" 0.104632613357112 0.547256913559781 0.488773586956521 0.198775459940094 0.808356400049876 0.40393752129741 0.0465632096759801 0.673636396626734 0.691875755742413 "PDGFRA MUT" "Bosutinib_IC_50" 0.219098577692651 0.692453909775927 0.991767837164746 0.198812080716673 0.808356400049876 0.848030958655456 0.573804670066466 0.949294892873838 0.426696484024671 "PIK3CA MUT" "BI.D1870_IC_50" 0.0549409264908446 0.418465152800335 0.458347738364785 0.198931174831028 0.808356400049876 0.268296511906209 0.394791440580945 0.915926348152589 0.213419368617107 "NF1 MUT" "Etoposide_IC_50" 0.363968643928219 0.787306955898826 0.483104431168824 0.198946543222468 0.808356400049876 -0.447505281675362 0.786980747330304 0.975087420732438 -0.147431690681332 "MYCN MUT" "MK.2206_IC_50" 0.185225521981188 0.660550500647272 0.527201442060086 0.199076819949534 0.808356400049876 0.422279284477209 0.13881901304399 0.831473272394224 0.697987206870258 "JAK2 MUT" "Metformin_IC_50" 0.32365142727982 0.765322958956319 0.540578639978059 0.199234303224022 0.808356400049876 0.6559669615943 0.582753131701567 0.949294892873838 0.321343260368904 "RUNX1 MUT" "Thapsigargin_IC_50" 0.584575067972429 0.876506729771444 -0.706552856643363 0.199343514774653 0.808356400049876 -1.25917495538675 0.523700535677364 0.940554660491705 -0.889550874006288 "TP53 MUT" "CMK_IC_50" 0.529447418463067 0.856314427858404 0.130166769016882 0.199405180803636 0.808356400049876 0.253650131555531 0.837458766962629 0.981704379975756 0.0478954018108923 "NF2 MUT" "EHT.1864_IC_50" 0.162399940569136 0.637610023074489 -0.394497735597734 0.199481251307184 0.808356400049876 -0.363314512112402 0.0172353245442959 0.513211661128791 -0.694093417607359 "MDM2 MUT" "Cisplatin_IC_50" 0.0423368665359957 0.370724581135392 1.07268264547206 0.199488075108259 0.808356400049876 0.587200068909501 0.0334490244593358 0.618827479917328 1.0701373468215 "KRAS MUT" "Bryostatin.1_IC_50" 0.0765225638424314 0.483908451254776 -0.265865106725792 0.199614541881919 0.808356400049876 -0.191956721559898 0.102629757867002 0.77902126462978 -0.2677851330742 "NRAS MUT" "Sorafenib_IC_50" 0.809653864758716 0.952641225877339 0.0967458430656941 0.199714485163516 0.808356400049876 0.509222778134004 0.475339758167074 0.929844139269115 0.330798502510523 "PTEN MUT" "CEP.701_IC_50" 0.572233477693825 0.872389778906173 -0.129967389074889 0.199755581905797 0.808356400049876 0.222711345164818 0.507268112632991 0.936600438314675 0.15036450288522 "APC MUT" "EHT.1864_IC_50" 0.557917972555313 0.86900908342163 -0.144603232904535 0.199841342905902 0.808356400049876 -0.330951806893596 0.397538170395529 0.916480913435499 -0.246561970936239 "FLCN MUT" "Erlotinib_IC_50" 0.430541338146492 0.820918238409269 -0.786450413625307 0.200109587231408 0.808356400049876 -1.1526279788466 0.00736840951893344 0.383871009534609 -4.57988831290173 "KDM5C MUT" "JNK.9L_IC_50" 0.329131910612648 0.770229380276924 -0.672218491349488 0.200153353082945 0.808356400049876 -0.689588048474626 0.429641421755896 0.922428741067589 -0.537880031244995 "MET MUT" "PF.562271_IC_50" 0.35792346442998 0.786601117838604 0.429344831873902 0.200155717555493 0.808356400049876 0.489373494966484 0.311578782360115 0.898149383211927 0.46339516319067 "BRCA2 MUT" "BI.D1870_IC_50" 0.0176086280830522 0.243626462607304 1.7119752854406 0.200210182856396 0.808356400049876 0.804157408821016 0.0771231764517451 0.741811190933953 1.22200924842488 "JAK2 MUT" "GDC.0449_IC_50" 0.151606569072486 0.625830613280407 0.666085795043158 0.200310086609026 0.808356400049876 0.530746626533824 0.398439074783403 0.916480913435499 0.423628852240455 "KRAS MUT" "Bleomycin_IC_50" 0.0748487794028147 0.480599432660364 -0.699560245109625 0.200429846767749 0.808356400049876 -0.431671592907949 0.391974124781572 0.915926348152589 -0.370892199476183 "SMAD4 MUT" "PAC.1_IC_50" 0.0659369003761195 0.458177989025628 0.603917865341058 0.200448779900877 0.808356400049876 0.361143452801011 0.125645571497844 0.817150972850516 0.521004508815699 "FGFR2 MUT" "NVP.TAE684_IC_50" 0.837686535567402 0.959212493377535 0.291819575757575 0.200619684837954 0.808356400049876 -1.5273615437709 0.165371179737017 0.84067330207935 -2.41224913609427 "EWS_FLI1 MUT" "AZ628_IC_50" 0.346576055536803 0.782020929432191 0.779823400637946 0.200900842180699 0.808356400049876 -0.857398516071191 0.714585181851357 0.962630898212352 0.300640656573715 "ERBB2 MUT" "AUY922_IC_50" 0.911231232674088 0.982267477694927 0.0519716986344527 0.200918500159416 0.808356400049876 -0.411169539951315 0.225280576931483 0.86643108387559 -0.572343914775861 "VHL MUT" "GDC0941_IC_50" 0.792480261070424 0.948304071878264 -0.170336231288988 0.201064630296656 0.808356400049876 0.670183081565772 0.46356379635147 0.929276781658587 0.511068170446879 "MLLT3 MUT" "NSC.87877_IC_50" 0.440435212262094 0.824500931653809 0.187657646103895 0.201103314220904 0.808356400049876 0.30401041952053 0.217218118927448 0.860928912580141 0.317338228732278 "MYCL1 MUT" "BI.2536_IC_50" 0.625113137491598 0.890724841246629 -0.456980783505158 0.201225057441426 0.808356400049876 -0.718719406995798 0.299063160302402 0.894167310052 -1.04829686914926 "CDKN2a(p14) MUT" "GW.441756_IC_50" 0.865576681465203 0.967741687593997 0.0184268450358795 0.201235667002449 0.808356400049876 0.139673078893693 0.292108062846082 0.891803870430294 0.126864943537542 "MET MUT" "Mitomycin.C_IC_50" 0.370306905179967 0.790171942552447 -0.604170382107296 0.201313861843318 0.808356400049876 -0.675352664025607 0.195393378449534 0.851001889249827 -0.850305178338376 "MS-HL MUT" "MK.2206_IC_50" 0.14424695128051 0.617666544298534 -0.359039807572208 0.201324892054758 0.808356400049876 -0.251021950785274 0.421042351861972 0.922428741067589 -0.211795930800066 "KDM6A MUT" "BI.2536_IC_50" 0.0254835108259778 0.297006639954736 -1.29679319906583 0.201367205391153 0.808356400049876 -0.443207794456207 0.0546366130099375 0.697305726351784 -1.25955459331716 "ALK MUT" "Z.LLNle.CHO_IC_50" 0.145894129042467 0.619919550890177 1.32668203082192 0.201429198661229 0.808356400049876 1.07546116749319 0.728442004259927 0.965402608571648 0.361181269712788 "KIT MUT" "BMS.754807_IC_50" 0.891505097823664 0.975972789421281 0.14104262062937 0.201864076100756 0.809735709056376 1.10332094188487 0.679216410479067 0.961100601384891 0.420225164430419 "FLT3 MUT" "GNF.2_IC_50" 0.253898997279674 0.719029653967086 0.829175746302607 0.202297558619553 0.810680938883192 0.890179340216577 0.208395659751201 0.853446327418758 0.935351135153545 "FLCN MUT" "AG.014699_IC_50" 0.199153029304499 0.674012093366938 -1.06859658951312 0.202305834534608 0.810680938883192 -0.933788839680655 0.724904692490086 0.965402608571648 -0.331665636805143 "CDKN2a(p14) MUT" "Paclitaxel_IC_50" 0.00796071789009005 0.156679237330372 -0.850095156701026 0.202451075129853 0.810680938883192 -0.190595185342036 0.244531518449874 0.875707386589409 -0.425534590773625 "MYCN MUT" "AMG.706_IC_50" 0.0232666050005177 0.277593371444066 -0.646714292475601 0.202614282746562 0.810680938883192 -0.348207654692945 0.128723011433451 0.820169751013594 -0.485539026645506 "NOTCH1 MUT" "FTI.277_IC_50" 0.0276732792387144 0.308798590144762 0.613808526501756 0.202729118090792 0.810680938883192 0.333271245597489 0.0633677495981444 0.70501719149803 0.541708224318577 "CDKN2a(p14) MUT" "Bosutinib_IC_50" 0.00935739547655105 0.170293092678791 -0.417119516009139 0.202743977520968 0.810680938883192 -0.172656596678227 0.0829688470877499 0.745860856369627 -0.287867979776144 "CDKN2A MUT" "JW.7.52.1_IC_50" 0.0668049247610608 0.459561995974423 -0.593110764550262 0.202898501103254 0.810680938883192 0.265565144970901 0.817052631357605 0.977383317127464 0.0882334978286305 "KRAS MUT" "AZ628_IC_50" 0.00138884177980809 0.0548424861786086 -1.89503312508295 0.202906185342484 0.810680938883192 -0.615367624288937 0.0819628450677872 0.744918262499236 -0.986849148684998 "FLT3 MUT" "Bicalutamide_IC_50" 0.121024892633427 0.580044291137328 0.482083080279242 0.202950591112517 0.810680938883192 0.380834526667602 0.332121265862743 0.903405836635744 0.284663099958339 "ERBB2 MUT" "Gemcitabine_IC_50" 0.0436201195467313 0.374825086237107 2.00964166974789 0.203012544541856 0.810680938883192 0.872659017307603 0.693531981157632 0.961100601384891 0.390470983618788 "NOTCH1 MUT" "SB590885_IC_50" 0.12905052758639 0.59046766383036 -0.748111441908722 0.203318495290425 0.810701695895022 0.547926220531307 0.551867636164165 0.947060194029534 -0.279656757294163 "TSC1 MUT" "JNK.Inhibitor.VIII_IC_50" 0.29492544006286 0.747036827777118 0.847328933333355 0.203348291487414 0.810701695895022 0.986095312418981 0.226705383793864 0.866945694839636 0.983625574358398 "PIK3R1 MUT" "AZD7762_IC_50" 0.0728251772408793 0.476610463578666 1.14059416377649 0.203357774705139 0.810701695895022 0.632272687008234 0.148422072734343 0.831473272394224 0.833713882754964 "FLT3 MUT" "SL.0101.1_IC_50" 0.0724869460980125 0.475447982493685 -1.26365596153844 0.203382882384203 0.810701695895022 -0.78679216699879 0.226766675950059 0.866945694839636 -0.821719074361679 "CDH1 MUT" "Dasatinib_IC_50" 0.493255035890759 0.843282996121548 1.20780175257732 0.203716164399741 0.811565748843081 1.88781939624793 0.462256003172656 0.929276781658587 1.15640810804949 "MDM2 MUT" "BI.D1870_IC_50" 0.0241668802491379 0.285027972765729 1.15556894003869 0.203790489134103 0.811565748843081 0.562991376204255 0.0294120165214494 0.59799127175549 1.05268290080812 "MSH2 MUT" "PLX4720_IC_50" 0.818398881812145 0.955210996106408 0.165148915057914 0.203873796382042 0.811565748843081 0.811234662803791 0.84912946568589 0.984337428855677 -0.125005578601128 "GNAS MUT" "Rapamycin_IC_50" 0.363023421376518 0.787293170741334 1.38034847635136 0.20423382455406 0.812634675566581 1.64646065272409 0.13788056685973 0.831473272394224 2.33838389581037 "GNAS MUT" "PAC.1_IC_50" 0.919796288359093 0.98596389099784 -0.0554438553791885 0.20452989019198 0.813448255617992 -0.584568667856093 0.469870839144704 0.929276781658587 -0.386555800449011 "PTEN MUT" "RO.3306_IC_50" 0.704998533246929 0.916033939102556 0.0703070425247737 0.204829374507636 0.813814338280645 0.229351685428588 0.448579479749353 0.925809648901546 0.153282960763842 "CDK6 MUT" "SB590885_IC_50" 0.800794261941286 0.9507092914502 -0.15448295573808 0.204988490291317 0.813814338280645 -0.648429214128926 0.649329959147324 0.957605341611987 -0.243194338374145 "CCND3 MUT" "PD.0332991_IC_50" 0.993669602996369 0.998970779334534 -0.011080682474229 0.205018021662676 0.813814338280645 -1.41134223306524 0.911134325214113 0.990184036004226 0.145086334229037 "FLT3 MUT" "CI.1040_IC_50" 0.156297609473456 0.63139838220137 1.46637906118549 0.205141899320743 0.813814338280645 1.18086264474913 0.0592629278558467 0.70215997387469 1.72616325557903 "BRAF MUT" "Roscovitine_IC_50" 0.629859357939271 0.892582202029064 0.191204279930596 0.205175157352604 0.813814338280645 0.486205319949751 0.932400770965148 0.994235539701634 0.043705919880534 "RUNX1 MUT" "VX.702_IC_50" 0.258500985541152 0.723084717001489 0.979824072657756 0.205198423790991 0.813814338280645 0.894693487881159 0.370576283682028 0.913948248824328 0.716453355656645 "APC MUT" "Tipifarnib_IC_50" 0.40000992732552 0.805918367644724 -0.347762292508562 0.205301916010725 0.813814338280645 -0.363008199479847 0.853568643520997 0.984631915507353 -0.091398519148227 "MLLT3 MUT" "ATRA_IC_50" 0.777420108840298 0.941790749776385 -0.116952636701663 0.205355019939976 0.813814338280645 -0.410884930030311 0.423845180218365 0.922428741067589 -0.305219479669963 "CDK4 MUT" "OSI.906_IC_50" 0.110727288194951 0.559686423710509 -1.15615687148507 0.205473927535277 0.813922368617661 -0.870202198437175 0.0605154611214892 0.702533085254831 -1.44964427560679 "FGFR3 MUT" "BX.795_IC_50" 0.386939885019631 0.799351737348069 0.978949157894714 0.205738606248216 0.814330163547097 1.10430634060547 0.399008998028003 0.916480913435499 0.837910622340773 "FBXW7 MUT" "BX.795_IC_50" 0.119945232808045 0.578243525361108 0.580443896722943 0.205760262020007 0.814330163547097 0.367022986071481 0.234188398923272 0.869962136993019 0.416243553254228 "EGFR MUT" "Sorafenib_IC_50" 0.451008748003009 0.828077050034054 -0.471842288194445 0.206190156625685 0.814895271256448 -0.744577015660915 0.550207040187842 0.947060194029534 -0.386391571463946 "VHL MUT" "SB.216763_IC_50" 0.225103722715494 0.696809397503067 -0.628604664694295 0.206245359005574 0.814895271256448 -0.634848391869091 0.690038336484646 0.961100601384891 -0.216396829529891 "TET2 MUT" "VX.702_IC_50" 0.478560914596088 0.836304203722611 -0.614703524537931 0.206268212410567 0.814895271256448 0.904848302229876 0.130863047770184 0.824721122422311 1.49841822295426 "CCND2 MUT" "CHIR.99021_IC_50" 0.372795183780775 0.792245519779148 -0.739945544041443 0.206270078795687 0.814895271256448 -0.988245094182782 0.711096274479724 0.962630898212352 -0.362720914498209 "PIK3R1 MUT" "CGP.60474_IC_50" 0.7569991156066 0.934762260113025 0.259569525773197 0.206562525158282 0.81568776608746 -0.786315460841692 0.633876246030207 0.952530446868743 0.385593163216006 "MDM2 MUT" "VX.702_IC_50" 0.803135507317363 0.951653961372316 -0.119271802325581 0.206965308521262 0.815885852098663 -0.493366916981499 0.625766708526374 0.951091592828953 -0.215815256395081 "HRAS MUT" "Gefitinib_IC_50" 0.114995444575257 0.567167686753817 1.04951114276609 0.207044429520001 0.815885852098663 0.757545711133551 0.0958103166369376 0.77097828178369 0.998738446896306 "NF2 MUT" "A.770041_IC_50" 0.00850008041366147 0.161994021789115 -2.15213297212545 0.207096921374988 0.815885852098663 -0.86020029249579 0.836358759461787 0.981626636221501 -0.176868234043719 "MLLT3 MUT" "Roscovitine_IC_50" 0.404511508468506 0.807904911469051 -0.448364680851066 0.207278046535454 0.815885852098663 -0.594712846909833 0.391265479739175 0.915926348152589 -0.486968712726403 "BCR_ABL MUT" "PAC.1_IC_50" 0.357265759262339 0.786601117838604 0.796997153577673 0.20730288250137 0.815885852098663 1.09255403895096 0.0273346935902622 0.588860092297546 1.87455302522479 "CDK4 MUT" "GW.441756_IC_50" 0.177926267030824 0.656868746076954 0.522715570327554 0.207308368331878 0.815885852098663 0.479575581004984 0.406052726109206 0.918000323669952 0.335312162166899 "EWS_FLI1 MUT" "BMS.708163_IC_50" 0.242132746489704 0.711340033600749 -0.399276359971839 0.207316746553406 0.815885852098663 -0.485585990528812 0.760199195388208 0.969901216545994 0.136422859594478 "SMO MUT" "AUY922_IC_50" 0.891057867527371 0.975972789421281 -0.183708064347827 0.207347637449238 0.815885852098663 1.13118781699042 0.650178688707309 0.957867556929346 -0.578627404737122 "EWS_FLI1 MUT" "AZD6482_IC_50" 0.936332204112412 0.988343059935435 0.0410890670194 0.207666775830017 0.816534871086661 0.586089586572027 0.49221100189963 0.933639405738697 -0.393477061420954 "MAP2K4 MUT" "AMG.706_IC_50" 0.42833689045533 0.820918238409269 -0.296598984063747 0.207696461410288 0.816534871086661 -0.434578829419849 0.0254929722096544 0.578483940084869 -0.851783782026496 "NOTCH1 MUT" "Bicalutamide_IC_50" 0.00990591505875248 0.176301466205974 0.404469371657755 0.207975508290132 0.817111434708916 0.193880572549245 0.41000558707411 0.921138279485245 0.133837201522518 "GNAS MUT" "JNJ.26854165_IC_50" 0.0544362812948776 0.417163714712476 0.736276203492794 0.208088600485283 0.817111434708916 0.449306090114042 0.352344081607087 0.91110953125066 0.338523198106966 "FLT3 MUT" "IPA.3_IC_50" 0.064865511545821 0.456953003353045 -1.90927175218154 0.20812123162297 0.817111434708916 -1.10591850468629 0.32700137572753 0.902483952227875 -0.949391852211237 "MYCL1 MUT" "Gemcitabine_IC_50" 0.475906885091433 0.835134084317001 -0.921481026455033 0.208236841906348 0.817111434708916 -1.08915906385651 0.180068157290519 0.848722027112292 -1.77121705194325 "KDM5C MUT" "Temsirolimus_IC_50" 0.619133480719374 0.887477435756715 0.803040092979122 0.208303151467288 0.817111434708916 1.55829453953432 0.60194815723687 0.949657634568742 0.7934713844541 "MSH6 MUT" "Midostaurin_IC_50" 0.414332328207378 0.813632830027793 0.542851674216026 0.208409137264442 0.817166246377709 0.642729901276229 0.339526267332484 0.907039453844874 0.573763969728864 "AKT2 MUT" "Gefitinib_IC_50" 0.670991718039956 0.906916702390321 -0.283165954110897 0.208627516474293 0.817661506534948 -0.754148947446085 0.427399726161527 0.922428741067589 -0.480408825785344 "MYC MUT" "AICAR_IC_50" 0.157510208407803 0.632962968719319 -0.39859363778706 0.208951826194708 0.818223834607786 -0.317765008436194 0.314104373387435 0.900294798053993 -0.285680826592421 "CDK4 MUT" "Nilotinib_IC_50" 0.906928621507721 0.981251818741413 -0.0611560635838156 0.209041053646535 0.818223834607786 -0.532709261459038 0.545731492800869 0.946853280734584 -0.297931543694788 "TSC1 MUT" "AZD8055_IC_50" 0.504407603147009 0.847595766822021 -0.671288657425753 0.209087667040872 0.818223834607786 -0.984570353977269 0.819094741207185 0.977383317127464 -0.222267704818617 "CDH1 MUT" "KU.55933_IC_50" 0.169300625511791 0.648365181185948 0.707824519549376 0.209139523089705 0.818223834607786 0.578072733320546 0.735241254632978 0.96672489654949 0.1886164779389 "FLCN MUT" "ABT.263_IC_50" 0.17228683442799 0.650961807890931 1.4891785509804 0.20944323675438 0.819041136842846 1.23152976699843 0.665244714144949 0.959206771190239 0.577853965528824 "EGFR MUT" "AZD6482_IC_50" 0.300245415575594 0.751119785777076 -0.433184800575564 0.20959261777513 0.819041136842846 -0.443979957791493 0.800170280762689 0.976360691959787 -0.108595970546135 "SETD2 MUT" "BIRB.0796_IC_50" 0.160510646043264 0.636336191287136 1.20780800000003 0.209663065787146 0.819041136842846 1.04632100721152 0.218943336000597 0.861955336129779 1.04688186391113 "MAP2K4 MUT" "AUY922_IC_50" 0.870550512535163 0.969692600253955 0.0865628408346947 0.209717322956945 0.819041136842846 0.447308767120157 0.923122336682901 0.993931766508607 -0.0538487526093036 "EZH2 MUT" "Paclitaxel_IC_50" 0.015970975992761 0.229883691720763 3.14371297440273 0.209951625941962 0.819392797826452 0.717685288541709 0.00802441657314489 0.395915797700554 3.95379442676436 "MLL_AFF1 MUT" "Sorafenib_IC_50" 0.061537453434824 0.447595515114392 -2.44705474237291 0.209991893689112 0.819392797826452 -1.59364665986696 0.112485898234411 0.797731604392475 -2.14969468360092 "TSC1 MUT" "Vorinostat_IC_50" 0.695318846085902 0.913718445479852 0.351213901574802 0.210580476679411 0.820631731055912 0.857399833612592 0.315755061556823 0.900294798053993 0.818422654443956 "PDGFRA MUT" "Gemcitabine_IC_50" 0.239354559401526 0.711026565113714 -2.14056995104896 0.210622404354639 0.820631731055912 -1.52480502437326 0.145189714395486 0.831473272394224 -2.52178546457448 "SMO MUT" "JNK.Inhibitor.VIII_IC_50" 0.285340582377276 0.740302864659114 -0.864316876190485 0.210648358172692 0.820631731055912 -0.962061000876623 0.219987764529392 0.863709697960004 -0.995047263396686 "CDKN2C MUT" "KIN001.135_IC_50" 0.102003316841374 0.542024654294532 -0.522922468714449 0.210703697596379 0.820631731055912 -0.393386416672496 0.0110080457973948 0.450437967177441 -0.922919301145907 "CTNNB1 MUT" "MG.132_IC_50" 0.0602732969049753 0.443886947376523 -1.82661239726028 0.210780946183078 0.820631731055912 -1.06790673606038 0.0104097605895095 0.450367315182713 -2.56337991694808 "SOCS1 MUT" "AZD6244_IC_50" 0.0451868561897356 0.38006499344648 -3.17296869278345 0.210863822798062 0.820631731055912 -1.80402510807934 0.00933366068170877 0.428092571279165 -3.66639556473289 "MSH6 MUT" "GNF.2_IC_50" 0.281751366749662 0.738375640008268 0.678710366438364 0.211124946205376 0.820956197127056 0.751791458081109 0.371251911838312 0.913948248824328 0.569681750744093 "STK11 MUT" "Midostaurin_IC_50" 0.684851080369019 0.910911925631994 -0.158079357526884 0.211132074567976 0.820956197127056 -0.375889751272075 0.395777829845802 0.916003810456352 -0.319973597393404 "STK11 MUT" "AZD.2281_IC_50" 0.0274431422746904 0.307955688765607 0.751479091836744 0.211416479154 0.821702298191106 0.322532385790388 0.290905965815888 0.891022884087089 0.340887653637325 "AKT2 MUT" "Obatoclax.Mesylate_IC_50" 0.91218874785969 0.982791249513758 -0.0965881343358391 0.2115868416812 0.822004698587374 0.803079531667154 0.991849793160607 0.999389382012633 -0.00868706339728625 "MS-HL MUT" "Dasatinib_IC_50" 0.187423671692559 0.663090109477269 0.88445048488477 0.211717370370191 0.822152149653549 0.693681307430749 0.348961543981909 0.909999728614578 0.619377258062799 "TSC1 MUT" "Etoposide_IC_50" 0.463484919212188 0.829490249358073 -1.27157647241381 0.212100851754134 0.823004018133802 -1.40876489215405 0.698698543837529 0.961100601384891 -0.634343157952503 "BCR_ABL MUT" "ABT.263_IC_50" 0.000117412051161421 0.0107498600656142 -4.17569103725491 0.212122080566183 0.823004018133802 -1.49309746729957 0.00837667284013387 0.402125575639075 -2.56906440519371 "RB1 MUT" "PF.02341066_IC_50" 0.224384986784279 0.696139064632428 0.325192223599674 0.212301520992588 0.823056765614397 0.32178056730498 0.326349423780994 0.901495873281184 -0.301277363841938 "MLLT3 MUT" "GSK.650394_IC_50" 0.895357801405656 0.977104034687102 0.0608500717711552 0.212379488778299 0.823056765614397 0.370887851496705 0.518196451373245 0.939635632721979 0.310822609567459 "BRCA1 MUT" "JW.7.52.1_IC_50" 0.674457978797418 0.908418658675584 -0.801594677966098 0.212413704176128 0.823056765614397 -1.43751353449376 0.5839825777476 0.949294892873838 -1.07523166327412 "FGFR3 MUT" "Temsirolimus_IC_50" 0.370937698649245 0.790579328077906 -1.44505431878557 0.212547938109143 0.823217722785563 -1.53489248571878 0.209080442410554 0.853446327418758 -1.91895638370429 "JAK2 MUT" "RDEA119_IC_50" 0.08382383811572 0.500295367140933 1.65842716167665 0.212838111264952 0.823852715359387 1.08036220746577 0.342780655361561 0.907180409180092 0.859964036423903 "MSH6 MUT" "CGP.60474_IC_50" 0.479301357833448 0.836304203722611 0.662127575342471 0.212897419406575 0.823852715359387 0.869670034522346 0.555008764597487 0.948071221654821 0.534726498947985 "NF1 MUT" "LFM.A13_IC_50" 0.107706714266739 0.552948315127282 0.378157887301837 0.213416087688229 0.824396551335691 0.277312887703156 0.449882407178919 0.925809648901546 0.191540342636852 "FGFR3 MUT" "TW.37_IC_50" 0.498400538741016 0.845109283443017 0.647260174887878 0.213525481027379 0.824396551335691 1.0784585574788 0.89591882333954 0.988301482344111 0.119529434356834 "KIT MUT" "CMK_IC_50" 0.865304004304491 0.967732635968793 0.205552734693878 0.213576546875148 0.824396551335691 1.41549201292576 0.658519859311535 0.958313128388245 0.552973444972723 "GNAS MUT" "Axitinib_IC_50" 0.99048763605804 0.998036562927507 0.00755350671784998 0.213699097159659 0.824396551335691 -0.663924236635598 0.515825418069649 0.939635632721979 -0.361063236415864 "CCND3 MUT" "DMOG_IC_50" 0.162089236644109 0.637610023074489 1.25448832179934 0.213721214770711 0.824396551335691 1.00519887886865 0.229210734588156 0.868145256417768 1.01877334846388 "BRCA2 MUT" "Bortezomib_IC_50" 0.985246310037971 0.996887811168928 0.0295425340136051 0.21387591952368 0.824396551335691 -1.61908108016878 0.705153717424065 0.962630898212352 -0.582766380800409 "MET MUT" "Midostaurin_IC_50" 0.108683293375711 0.555360373112595 -0.911394510269059 0.214062393017177 0.824396551335691 -0.54618639330165 0.111017213443567 0.797376436030023 -0.822099671721566 "EP300 MUT" "Methotrexate_IC_50" 0.226870997575122 0.699346740297147 1.54927677710841 0.214067766007253 0.824396551335691 1.21705512888389 0.468083301432212 0.929276781658587 0.733001041796266 "MSH6 MUT" "AZD.0530_IC_50" 0.437406053865034 0.823808548892323 -0.790025013559315 0.21415236628236 0.824396551335691 -1.08976720663471 0.141603823531904 0.831473272394224 -1.39621032373184 "TP53 MUT" "WH.4.023_IC_50" 0.0398098069484324 0.361141839503332 0.881846227805364 0.214213440185978 0.824396551335691 0.499871731528417 0.245198446501145 0.875707386589409 0.513768976124444 "MAP2K4 MUT" "ZM.447439_IC_50" 0.0630540961925682 0.450893824743909 0.866331804116872 0.214238663833908 0.824396551335691 0.460800805412296 0.570945520388429 0.949294892873838 0.276718619123161 "FGFR2 MUT" "ABT.888_IC_50" 0.350195278016401 0.784966682190403 -0.699449474285719 0.214249550469673 0.824396551335691 -0.79030260284368 0.0621846196673993 0.702860976445846 -1.84027962429514 "CCND2 MUT" "Bicalutamide_IC_50" 0.197534977671445 0.673916763680921 0.46238684088269 0.214306394936237 0.824396551335691 0.421444118339554 0.102320746750422 0.778005609495289 0.670748783358479 "MSH6 MUT" "PD.0332991_IC_50" 0.907917752893334 0.981284844036229 0.093650292446293 0.214380674204775 0.824396551335691 0.802685149118143 0.741905006511117 0.96672489654949 0.247745688665871 "NF1 MUT" "PHA.665752_IC_50" 0.113244206345112 0.564061579669622 0.638112256944446 0.214430360723505 0.824396551335691 0.502170113705903 0.412052247563619 0.921714070263062 0.39133041065837 "NF1 MUT" "BI.2536_IC_50" 0.0537493675281673 0.413646562406979 1.2851532 0.214890067126271 0.825175098939446 0.494672082835583 0.285789027985539 0.8879937007725 0.852651305814702 "CDK6 MUT" "VX.702_IC_50" 0.223167867873155 0.696139064632428 0.613329961315276 0.214905510104714 0.825175098939446 0.509755343845453 0.515494405554313 0.939635632721979 0.304234893849214 "EGFR MUT" "CGP.60474_IC_50" 0.836222001854686 0.959122768755193 -0.123699532867133 0.2149116094862 0.825175098939446 -0.547636805784079 0.681600697344232 0.961100601384891 0.241638197808937 "JAK2 MUT" "Axitinib_IC_50" 0.0772788942244521 0.486043076549996 1.19368110673235 0.215026891438063 0.825260943328194 0.708191504939336 0.0868394317834894 0.753881714241612 1.10629180387158 "MSH2 MUT" "MG.132_IC_50" 0.119427045738785 0.577057450057752 1.65714955631399 0.215241179581751 0.825726529531547 1.17041662579604 0.606216308592257 0.949657634568742 0.517888203755428 "PIK3R1 MUT" "FTI.277_IC_50" 0.0775798367344837 0.486980385654137 0.738531026583865 0.215477207520844 0.826150074719894 0.472109906257052 0.142588504984039 0.831473272394224 0.580350209440731 "KRAS MUT" "Parthenolide_IC_50" 0.793150114046896 0.948304071878264 0.0926025205119794 0.215537633501407 0.826150074719894 0.438041126636127 0.735469541295824 0.96672489654949 -0.134253497576124 "CTNNB1 MUT" "NSC.87877_IC_50" 0.520662176642608 0.852599738673405 0.188066278659611 0.215934969575771 0.826707670912125 0.355362570825205 0.174396867582539 0.84578207413725 0.452922084620256 "MET MUT" "Parthenolide_IC_50" 0.546341921794679 0.86289571535809 -0.682183232323223 0.215973865194559 0.826707670912125 -1.28943503618684 0.601011629107186 0.949657634568742 -0.608441337393259 "PIK3CA MUT" "Temsirolimus_IC_50" 0.0362489667453243 0.348463542926957 0.696018618368011 0.216013132398716 0.826707670912125 0.319316567783192 0.0395355327024219 0.64992634601437 0.714273898153662 "KIT MUT" "GW843682X_IC_50" 0.953879940868243 0.992679871625456 -0.100071016949153 0.216130903451075 0.826707670912125 1.143452124737 0.906672519381879 0.988965689588611 0.212042803000638 "ERBB2 MUT" "CEP.701_IC_50" 0.000178100992638044 0.0146455084779488 1.69497820726102 0.216297709306102 0.826707670912125 0.426830143104833 0.0937169933812284 0.768513959574043 0.737114963809187 "NOTCH1 MUT" "CGP.082996_IC_50" 0.794958905156768 0.948646027682356 -0.130613049441785 0.21635488521121 0.826707670912125 0.543813495323659 0.976319122508814 0.99742775226181 0.0170172490263759 "MSH6 MUT" "QS11_IC_50" 0.106335309859455 0.550328605397333 -1.12629137653779 0.216491474644727 0.826707670912125 -0.632915330239743 0.164030465513933 0.839927262232576 -0.941626828897963 "BCR_ABL MUT" "Lenalidomide_IC_50" 0.00149047643660185 0.0569603689624804 -1.68434428571431 0.216541598915748 0.826707670912125 0.701275767783072 0.116629304529638 0.802933994982728 -0.8244455145189 "BRCA2 MUT" "X17.AAG_IC_50" 0.994093480421738 0.998977896287767 0.00730123563218322 0.216616783972843 0.826707670912125 -1.07852833265577 0.877595230504961 0.987838063957761 -0.134646370643513 "FLCN MUT" "ATRA_IC_50" 0.681909468240053 0.909861476478352 -0.354837729885059 0.216705598769121 0.826707670912125 -0.841157998539122 0.614421039506836 0.950059945073224 0.539046916003756 "CDK6 MUT" "AMG.706_IC_50" 0.554135184294324 0.866925654369292 -0.255074105610562 0.216707066533434 0.826707670912125 -0.489538994097454 0.21379335017157 0.859314544932072 -0.493028226265681 "MYC MUT" "BIBW2992_IC_50" 0.442949239166408 0.825539266593482 -0.23653813459616 0.217011864783137 0.826844774038462 -0.366410286626977 0.643155310463771 0.955972780483685 -0.138034134813537 "GNAS MUT" "MS.275_IC_50" 0.349679618793207 0.784966682190403 1.03204252405498 0.217077848969986 0.826844774038462 1.12795805277358 0.215062880654589 0.859961027957408 1.46141287561404 "MSH2 MUT" "CGP.60474_IC_50" 0.270577919106806 0.733000988154624 0.923341896907222 0.217114970131025 0.826844774038462 0.774095981908776 0.270364767220336 0.879527288528866 0.912319241765397 "FLT3 MUT" "AZD6244_IC_50" 0.282975198819516 0.739347745684876 1.39223839669417 0.217118035685749 0.826844774038462 1.46755466563712 0.148253156350537 0.831473272394224 1.68098606517552 "BRAF MUT" "RO.3306_IC_50" 0.240999776387472 0.711340033600749 0.247737937198069 0.217208519066742 0.826844774038462 0.274139429926216 0.353101330670923 0.911252930312559 0.235987743680845 "FBXW7 MUT" "Camptothecin_IC_50" 0.440891219955403 0.824500931653809 -0.369122306324108 0.217549614049997 0.827468670025447 -0.374428614099507 0.737896838881691 0.96672489654949 -0.14987517092078 "KDR MUT" "Pazopanib_IC_50" 0.0536893734067134 0.413543213551623 -2.10093579616722 0.217631341591446 0.827468670025447 -1.14180201200783 0.364208606728645 0.912937238599238 -0.912955994827317 "PDGFRA MUT" "TW.37_IC_50" 0.140066619421596 0.610368816036894 -0.894362099322799 0.217838570766332 0.827468670025447 -0.679400200846632 0.193405899098495 0.851001889249827 -0.766720975458726 "BCR_ABL MUT" "JW.7.52.1_IC_50" 0.264036348402813 0.726560302215652 -1.51094617747439 0.217864110419544 0.827468670025447 1.2894337907662 0.433637629851723 0.922569292988365 -1.09473799696767 "FAM123B MUT" "BIRB.0796_IC_50" 0.128165635871498 0.588664235316545 0.927489053537277 0.217912739416814 0.827468670025447 0.720545406084437 0.186230997635617 0.851001889249827 0.809376141133048 "JAK2 MUT" "DMOG_IC_50" 0.702027152121911 0.915500829364901 -0.260383204968951 0.217987585027347 0.827468670025447 -0.753667914712463 0.531932603587062 0.94320946427311 -0.436439756926887 "EP300 MUT" "Midostaurin_IC_50" 0.26799291112248 0.731489745211169 -1.1974342124352 0.218109870124782 0.827468670025447 -1.02979358587147 0.490354547733505 0.933639405738697 -0.67446642545732 "MDM2 MUT" "Thapsigargin_IC_50" 0.101459897979138 0.542024654294532 1.50172623633157 0.218270033883594 0.827468670025447 0.860613353848642 0.0862518448961168 0.750982975021974 1.52311980027374 "PTEN MUT" "JNJ.26854165_IC_50" 0.0449688939394777 0.3789077296741 -0.313935463210062 0.218337591092753 0.827468670025447 -0.185199438634318 0.160224232456505 0.838901067822678 -0.227771946288825 "KDM6A MUT" "CGP.082996_IC_50" 0.63963480748692 0.895624997957207 -0.196826285714284 0.21839240085882 0.827468670025447 0.437598975089222 0.98894410991814 0.998559633198815 -0.00627277260049502 "VHL MUT" "Imatinib_IC_50" 0.28957778304919 0.745215963853913 -0.663700353741497 0.218477806832665 0.827468670025447 -0.768745504898156 0.375907785278643 0.914419412871569 -0.685880428134148 "CTNNB1 MUT" "AICAR_IC_50" 0.179521916414626 0.658614416960816 0.646032851930673 0.218490488819916 0.827468670025447 0.530704745192355 0.324045080471858 0.900918773778407 0.497988155521805 "EZH2 MUT" "AP.24534_IC_50" 0.439531503151299 0.824500931653809 0.813376079503122 0.219035661870926 0.827737676925922 1.16363923326078 0.956758373863648 0.996361528879345 -0.057799532957506 "ALK MUT" "FH535_IC_50" 0.181584681741873 0.658636992153339 1.50325401217392 0.219060408625193 0.827737676925922 1.18636827309568 0.50403810425285 0.93503055238173 1.01459787139405 "BCR_ABL MUT" "Bryostatin.1_IC_50" 0.952781904890587 0.992561499112566 0.0374544083769638 0.219524672158384 0.827737676925922 0.878526107359575 0.668539556552064 0.959230524020512 -0.263825139384571 "ERBB2 MUT" "Methotrexate_IC_50" 0.0277565095303932 0.309275185547668 1.27507489917695 0.219576326852814 0.827737676925922 0.559836939533546 0.39689494946439 0.916480913435499 0.415699835827168 "JAK2 MUT" "PAC.1_IC_50" 0.0621672334538576 0.448539201336004 1.22241272130328 0.219778096685472 0.827737676925922 0.674206495981348 0.0896328446553677 0.761022269009867 1.16669430724537 "IDH1 MUT" "IPA.3_IC_50" 0.314334183214886 0.760194346847454 -1.4705330678261 0.219975909277986 0.827737676925922 -1.49765220413187 0.299223200071431 0.894167310052 -1.41843691801566 "SMAD4 MUT" "Nilotinib_IC_50" 0.793013212570064 0.948304071878264 0.0849331142836064 0.220003965818443 0.827737676925922 -0.330089875088258 0.3843477176764 0.915331032347709 -0.268878528975446 "MAP2K4 MUT" "Parthenolide_IC_50" 0.432041808907775 0.821267830674218 0.630261457627116 0.220126257910149 0.827737676925922 0.918512569345392 0.338985041865533 0.906784986990301 0.917462589533865 "BRCA1 MUT" "Shikonin_IC_50" 0.150130777086248 0.624794485146659 1.3210271646447 0.220259276356263 0.827737676925922 0.948463747806351 0.224614264165084 0.86643108387559 1.09072659089146 "MYCN MUT" "BMS.509744_IC_50" 0.405355292058514 0.807904911469051 0.326096268115943 0.220318970898013 0.827737676925922 0.37213253267549 0.262690746810733 0.877052916121269 -0.519489357043249 "MLLT3 MUT" "S.Trityl.L.cysteine_IC_50" 0.971269794385001 0.995220468612913 0.0241788146853146 0.22032681926299 0.827737676925922 -0.445710818489011 0.77149345866719 0.969901216545994 -0.209323765881061 "MYCL1 MUT" "Metformin_IC_50" 0.250663941942838 0.717470497840808 -0.589007115384618 0.220361331658299 0.827737676925922 -0.584774112289008 0.430049664582066 0.922428741067589 -0.434816007934828 "CDK4 MUT" "Thapsigargin_IC_50" 0.219730734780152 0.692721312918376 -1.25651912390159 0.220389387172249 0.827737676925922 -0.96127023220235 0.41716097187966 0.922428741067589 -0.857047270583167 "TET2 MUT" "Etoposide_IC_50" 0.402427939948086 0.807127943694435 -1.18670549913641 0.220408606739651 0.827737676925922 1.14096694363653 0.756854233157153 0.969901216545994 -0.509551521911423 "ERBB2 MUT" "A.443654_IC_50" 0.186347517602122 0.662380873013605 -1.55289066894198 0.220442370882374 0.827737676925922 -0.954070950771499 0.413752889215895 0.921714070263062 -1.00738793715062 "MYC MUT" "QS11_IC_50" 0.517969323621998 0.852353345422823 -0.200943101254247 0.220465062355287 0.827737676925922 -0.281792462536604 0.192187259233232 0.851001889249827 -0.418023879132291 "CDKN2A MUT" "IPA.3_IC_50" 0.457912924886641 0.828966839128293 0.128886317261684 0.220492421902885 0.827737676925922 0.187524512087107 0.56851338956159 0.949294892873838 0.105330074745927 "PIK3CA MUT" "Gefitinib_IC_50" 0.0397681328248338 0.361141839503332 0.486581455894215 0.220501666617867 0.827737676925922 0.265425306834664 0.00464678382619256 0.349220649476767 0.662461081909392 "HRAS MUT" "QS11_IC_50" 0.0888919104680529 0.513295875726124 1.49674072202796 0.220591088140273 0.827737676925922 0.796080839308083 0.101047247388154 0.774133667469059 1.40905949341415 "BRCA2 MUT" "Metformin_IC_50" 0.459397721645375 0.828966839128293 -0.478637820267697 0.220604067788429 0.827737676925922 -0.743618764612342 0.466133177904829 0.929276781658587 -0.466741548678412 "EZH2 MUT" "Nilotinib_IC_50" 0.679277820025472 0.909081723876766 0.304366818702293 0.220623611193565 0.827737676925922 0.727587788599511 0.925862957309996 0.994026707431102 0.0614555742236542 "KDM6A MUT" "JW.7.52.1_IC_50" 0.280440227595175 0.737882141891724 -0.745537891459073 0.22066843219682 0.827737676925922 0.514916179603754 0.455061385496441 0.925809648901546 -0.570671190733369 "IDH1 MUT" "PD.173074_IC_50" 0.269575029459566 0.732139399581163 1.12615195312499 0.220705192991846 0.827737676925922 1.06098084168451 0.138691995962811 0.831473272394224 1.39687715132071 "NF1 MUT" "SL.0101.1_IC_50" 0.980031786404065 0.996332002460735 0.00663529305026295 0.220974705307147 0.828398631419492 -0.284288970245924 0.516956981008764 0.939635632721979 -0.179876744990272 "CCND3 MUT" "Tipifarnib_IC_50" 0.364569508726462 0.787388571741174 1.0180831867365 0.221163336107983 0.828408710844164 0.914775715095729 0.227308092893765 0.867648638924452 1.33460305443472 "APC MUT" "PD.0332991_IC_50" 0.00134505768419404 0.0536789144563151 1.24475906948471 0.221286452200197 0.828408710844164 0.401895859616355 0.206439951000933 0.853446327418758 0.56871285601737 "BRAF MUT" "ABT.263_IC_50" 0.0853613540154851 0.503679085433888 0.537628337761678 0.221349008568548 0.828408710844164 0.37781506271808 0.94694853388576 0.995668765770473 0.0217474032333803 "MLLT3 MUT" "Mitomycin.C_IC_50" 0.51748281773867 0.852353345422823 0.318778865279208 0.221516113725063 0.828408710844164 0.470379831420638 0.17165855992502 0.842832361237713 0.683252027412981 "FAM123B MUT" "Bryostatin.1_IC_50" 0.23669082528421 0.709433418612578 -0.669630935314694 0.221554822707236 0.828408710844164 -0.651685555236988 0.269363591315718 0.878819138279722 -0.605489288967576 "BRAF MUT" "AICAR_IC_50" 0.0955091603830447 0.528484020786181 0.410477025089602 0.221573101628511 0.828408710844164 0.295647430899214 0.376732272393968 0.914419412871569 -0.247316549539491 "CDK6 MUT" "CCT018159_IC_50" 0.351429032845081 0.784966682190403 -0.470094212962962 0.221630345340134 0.828408710844164 -0.571733196564892 0.372602797442379 0.913948248824328 -0.451644168053239 "ERBB2 MUT" "CMK_IC_50" 0.493065207452857 0.843282996121548 0.679096600682594 0.221835295963535 0.828472065781134 1.13031255212706 0.48731759693976 0.933639405738697 0.722994697171131 "FBXW7 MUT" "WO2009093972_IC_50" 0.864115581739112 0.967489995749939 -0.0742847739589015 0.221963914142876 0.828472065781134 -0.478519317402847 0.126452937081526 0.817150972850516 -0.694830474416765 "FGFR2 MUT" "MS.275_IC_50" 0.0459915575007233 0.382803207276405 2.53166194178081 0.222033920728882 0.828472065781134 1.32066845068073 0.260576115657873 0.877052916121269 1.81359491552837 "SMARCA4 MUT" "CMK_IC_50" 0.246723474725714 0.714668105985286 1.14676986575653 0.222046739538722 0.828472065781134 1.10643832305524 0.43226846012257 0.922569292988365 1.36743047082889 "AKT2 MUT" "BIRB.0796_IC_50" 0.459916567352843 0.828966839128293 -0.368858573256561 0.222113724650927 0.828472065781134 -0.582134201913034 0.668944272711205 0.959230524020512 -0.212719547721288 "RUNX1 MUT" "Metformin_IC_50" 0.272874401563556 0.734000646544246 0.913746476190485 0.222352081189386 0.829012944182593 0.94485858035018 0.349641348716164 0.909999728614578 0.758261096256656 "PDGFRA MUT" "Axitinib_IC_50" 0.168331752718253 0.647446641789 -1.09984119847329 0.222512661939903 0.829263512668181 -0.822052609016936 0.255513326172874 0.875707386589409 -0.809682568478584 "MET MUT" "BAY.61.3606_IC_50" 0.726543410098816 0.92547791524492 0.203513143912625 0.222719299531539 0.829685444269966 0.494564280775419 0.554932734332132 0.948071221654821 -0.323252956552425 "TET2 MUT" "BAY.61.3606_IC_50" 0.564944540268111 0.871775968539349 -0.636746386759574 0.223013867693978 0.830434448213929 0.947598925138783 0.831815696209073 0.981482581683432 0.270413372744171 "EWS_FLI1 MUT" "Pyrimethamine_IC_50" 0.103743795793273 0.546119906272292 -1.1596311888112 0.223268790381771 0.831035258751261 -0.798059917295065 0.203506951061458 0.852959543285214 -1.04399808267853 "CCND1 MUT" "Bleomycin_IC_50" 0.116700449587515 0.571973892266404 1.01884363030303 0.223541677178876 0.831105703551342 0.649329629671182 0.169146901325126 0.84067330207935 0.922788334867632 "NF1 MUT" "Shikonin_IC_50" 0.925982577272611 0.98643792569589 0.0413049438311674 0.223618837444756 0.831105703551342 -0.458041106644724 0.792220857676007 0.975393509832241 -0.123631020042971 "MLL_AFF1 MUT" "GW.441756_IC_50" 0.361824787419456 0.787203806240126 0.785514176470582 0.223698816734818 0.831105703551342 1.04480567522831 0.388447382173726 0.915926348152589 0.745334189493658 "KIT MUT" "WH.4.023_IC_50" 0.75251244049917 0.933649480870792 -0.794435353741499 0.223801982275044 0.831105703551342 2.77217253468829 0.481086142890833 0.930456985059316 1.67099288512716 "MAP2K4 MUT" "JNJ.26854165_IC_50" 0.161802958273613 0.637610023074489 0.50915671232876 0.223844194959548 0.831105703551342 0.41319223108037 0.510832570131556 0.938693162701913 0.240799213265786 "NOTCH1 MUT" "SB.216763_IC_50" 0.802823908869645 0.951554805207856 -0.102076228930434 0.223849211000429 0.831105703551342 0.50071832341837 0.739963581069506 0.96672489654949 0.141874121674484 "CDK6 MUT" "Roscovitine_IC_50" 0.426482295178327 0.81941696345643 -0.771448904267593 0.224108263294892 0.831156783791684 -1.03477407968831 0.287781341992175 0.888563331668781 -1.26137921564981 "RUNX1 MUT" "BX.795_IC_50" 0.198761498277519 0.674012093366938 -1.18790646923595 0.224132006488721 0.831156783791684 -0.863981858077207 0.161659536650893 0.839927262232576 -1.12959525774347 "RUNX1 MUT" "Lenalidomide_IC_50" 0.152493801051548 0.625830613280407 0.87854071609632 0.224286905085037 0.831156783791684 0.652847170844019 0.186346479452156 0.851001889249827 0.771769923753814 "MSH2 MUT" "QS11_IC_50" 0.035716912566345 0.347105523744792 -1.56325715012533 0.224289058533089 0.831156783791684 -0.670755485035633 0.0906708829418698 0.764118629741502 -1.24163279923059 "KDR MUT" "ATRA_IC_50" 0.213572533125975 0.688117861819268 1.24140759400894 0.224330909891754 0.831156783791684 0.955340865770505 0.358994965044201 0.91161229252998 0.811389056387055 "VHL MUT" "FTI.277_IC_50" 0.0495292374899854 0.396635850449559 -0.769190119773506 0.224600505033836 0.831535097079011 -0.435712954110422 0.331064018007966 0.902810042912437 -0.39206681213628 "FGFR2 MUT" "S.Trityl.L.cysteine_IC_50" 0.0126747011675199 0.20318415355369 3.00275798748577 0.224672737618239 0.831535097079011 0.824069772662494 0.114669744641879 0.799692247086917 2.36602477782674 "BRCA1 MUT" "MS.275_IC_50" 0.35179435683883 0.784969887597353 -1.44817692150172 0.224713909806286 0.831535097079011 -1.56324156550686 0.430965198969779 0.922569292988365 -1.28855030370744 "MDM2 MUT" "Camptothecin_IC_50" 0.0163697855345529 0.233354840019847 1.71749323699422 0.224816011015186 0.831566428082411 0.550237434704779 0.0142588729227532 0.48705019394989 1.53840702416343 "MSH2 MUT" "BMS.708163_IC_50" 0.379190210748125 0.796120156419408 0.535858011210769 0.22511065352328 0.832222561281724 0.747415160258153 0.41325524881418 0.921714070263062 0.504552297374294 "RB1 MUT" "A.770041_IC_50" 0.20708142487179 0.680161611517635 0.531306105017396 0.225247538653991 0.832222561281724 0.434088185686697 0.365914383704976 0.913948248824328 -0.424356312966223 "CDKN2C MUT" "Obatoclax.Mesylate_IC_50" 0.0787809170001386 0.487563291901206 1.28978682716049 0.225313334702346 0.832222561281724 0.656603795545399 0.318791432600911 0.900918773778407 0.838153192383088 "MLL_AFF1 MUT" "PD.0325901_IC_50" 0.0998064915002592 0.5374999166548 2.61626026336637 0.225368231041836 0.832222561281724 1.84228596151461 0.12462634247664 0.817150972850516 2.16337248427748 "GNAS MUT" "Gemcitabine_IC_50" 0.0586193799770701 0.43716683516022 2.44105516402116 0.225566063559838 0.832300599419696 1.04664044465976 0.285817980540115 0.8879937007725 1.3015991344768 "MLL_AFF1 MUT" "Nilotinib_IC_50" 0.253167786349987 0.717874556377469 -1.32556156925995 0.225832432304492 0.832300599419696 1.15964402018172 0.736541590662447 0.96672489654949 0.355332060356892 "VHL MUT" "Thapsigargin_IC_50" 0.544553557669186 0.862633715268747 0.620703222319858 0.225867432610292 0.832300599419696 0.949668967626529 0.656151745558674 0.958313128388245 0.480406909830427 "AKT2 MUT" "NVP.TAE684_IC_50" 0.282014432035587 0.738375640008268 1.87203159060401 0.225934616660387 0.832300599419696 1.71076561423364 0.176710714861672 0.848618686837376 2.36458947754684 "ALK MUT" "Rapamycin_IC_50" 0.197448358561952 0.673916763680921 1.95447094256758 0.225980091518375 0.832300599419696 1.58740926329226 0.618970905226383 0.950394619652337 0.894301783758322 "NF1 MUT" "Roscovitine_IC_50" 0.606820943743162 0.883471606784102 -0.244159856630824 0.226262028236294 0.832300599419696 -0.508702452541679 0.779141030228313 0.972337708041191 0.151406868599336 "VHL MUT" "AZD.2281_IC_50" 0.173891349547937 0.651401757469953 0.724961264940245 0.226382094975204 0.832300599419696 0.489747436887233 0.369594083691269 0.913948248824328 0.456495285819567 "SMARCA4 MUT" "PD.0332991_IC_50" 0.528400772108001 0.855147571292734 -0.442899482776616 0.226485436356559 0.832300599419696 -0.674231486794622 0.252019304548711 0.875707386589409 -0.881019546395132 "EWS_FLI1 MUT" "CCT018159_IC_50" 0.901995075955099 0.979694707150557 -0.049042172581516 0.226648359842372 0.832300599419696 0.49725247261067 0.198036315274671 0.851001889249827 0.669831148722874 "SETD2 MUT" "X681640_IC_50" 0.0717718153171326 0.474889173046706 2.07729752941172 0.226701489868825 0.832300599419696 1.20195194540055 0.139914969072307 0.831473272394224 1.60040418039283 "CTNNB1 MUT" "GW.441756_IC_50" 0.255162805766883 0.720311238267775 0.388455929189023 0.226726964346395 0.832300599419696 0.405344309161308 0.465851253398538 0.929276781658587 0.269705768754113 "EP300 MUT" "LFM.A13_IC_50" 0.384715783611357 0.798746759187088 -0.556309872241574 0.226945626038212 0.832300599419696 -0.730562232797295 0.572615260574175 0.949294892873838 -0.357617479433115 "MSH6 MUT" "NU.7441_IC_50" 0.407669027164451 0.809352267869285 -0.532234178571433 0.227076261011996 0.832300599419696 -0.681619468558618 0.24167699502142 0.875707386589409 -0.722998177525234 "MYCN MUT" "Nutlin.3a_IC_50" 0.064218785734891 0.454771088100903 -0.768143327924262 0.227107539402582 0.832300599419696 -0.475998848147788 0.294880660987231 0.894167310052 -0.511851032114461 "CCND3 MUT" "SL.0101.1_IC_50" 0.699805818278114 0.915410639012359 -0.332428694817653 0.227310817382916 0.832300599419696 -0.905509528395928 0.719569153202072 0.964898274809486 -0.295951341265425 "CDKN2A MUT" "Bleomycin_IC_50" 0.00212686142422651 0.0691892172474566 -0.848982096883813 0.227541653020664 0.832300599419696 -0.286621469957289 0.319785428692741 0.900918773778407 -0.304321487227581 "KDM6A MUT" "SB.216763_IC_50" 0.0318805654257893 0.329263246012996 -0.816503246666659 0.227661016504631 0.832300599419696 -0.447336555218951 0.310396855166682 0.89718581932126 -0.386735980673368 "KRAS MUT" "Cisplatin_IC_50" 0.000695864451851319 0.0355041590677904 0.659025414667433 0.227667960789242 0.832300599419696 0.215674669029717 0.0429268553956545 0.658180729724545 0.439307964607304 "KDR MUT" "Thapsigargin_IC_50" 0.152451909280157 0.625830613280407 -2.38142530894306 0.227846352758146 0.832300599419696 -1.53132715634119 0.35358639281363 0.911252930312559 -1.51655337265726 "TP53 MUT" "AZD7762_IC_50" 0.39640380661003 0.804493191614186 0.139955516252266 0.227853633150391 0.832300599419696 -0.163480913669997 0.848496562693014 0.984003391652736 -0.0308424315711593 "MSH6 MUT" "X681640_IC_50" 0.949862903850454 0.991622481379556 -0.0421228384458073 0.227863382193615 0.832300599419696 0.690615438583365 0.825253151351122 0.980029315589217 0.137889165566463 "MYC MUT" "Vinorelbine_IC_50" 0.15558445204275 0.630934026754184 0.45047711304495 0.227935986169999 0.832300599419696 0.283373439442396 0.201009024629277 0.851001889249827 0.42125187391099 "MET MUT" "JNJ.26854165_IC_50" 0.551598904178501 0.865580796066258 -0.207013122529646 0.227942505023687 0.832300599419696 -0.391915688653989 0.217890359785005 0.860928912580141 -0.403466364380493 "MYC MUT" "Vinblastine_IC_50" 0.707931736275367 0.917830912388545 -0.108820892343062 0.227981639131052 0.832300599419696 -0.254229413566963 0.631842704925253 0.952523560833852 -0.136622702052348 "MDM2 MUT" "Sunitinib_IC_50" 0.589099417067303 0.876506729771444 -0.574203859106532 0.228030198298744 0.832300599419696 -0.942786739568764 0.471403578201212 0.929276781658587 -0.669823131950091 "TET2 MUT" "KIN001.135_IC_50" 0.429427586358939 0.820918238409269 -0.356152477477479 0.228201387303958 0.832300599419696 -0.53645248646582 0.867037039640276 0.987077901072027 -0.0863890955226473 "SMAD4 MUT" "DMOG_IC_50" 0.138210547626842 0.606087209949663 0.505024842551603 0.228325053726613 0.832300599419696 0.380077808989528 0.948994927355242 0.995668765770473 0.0221036448851613 "PIK3CA MUT" "ABT.263_IC_50" 0.0303334286997726 0.32301100753319 0.706056388281768 0.228332735094368 0.832300599419696 0.357938458986685 0.348886052123359 0.909999728614578 0.293003718810461 "STK11 MUT" "CGP.082996_IC_50" 0.312992605001566 0.759215564942334 0.743755154639177 0.228446992172642 0.832300599419696 0.747572319663455 0.258100981208885 0.877052916121269 0.938919231768427 "CDKN2C MUT" "Lapatinib_IC_50" 0.493946444233732 0.843282996121548 0.502440081585079 0.228511082187862 0.832300599419696 0.764812014976439 0.361516910827377 0.91161229252998 0.71422925552615 "TP53 MUT" "AMG.706_IC_50" 0.734227730046949 0.928593402067957 0.0407546405128468 0.228558507728227 0.832300599419696 -0.13949758948524 0.100630455498749 0.774133667469059 -0.195301725644516 "KDM5C MUT" "QS11_IC_50" 0.426817900951049 0.81941696345643 0.781719900523574 0.228599644988705 0.832300599419696 0.870639965875235 0.353161979200291 0.911252930312559 0.888256827281651 "MLL_AFF1 MUT" "Bexarotene_IC_50" 0.18683967476095 0.662404451717364 -1.50066344521741 0.228637391638317 0.832300599419696 -1.24059260099628 0.125457569391717 0.817150972850516 -1.67411570942461 "MLH1 MUT" "MK.2206_IC_50" 0.184378178546237 0.660385845878234 -0.756582668763099 0.228647989832677 0.832300599419696 -0.556894073082466 0.622201905480664 0.950496524771391 -0.277593176900454 "ERBB2 MUT" "Bleomycin_IC_50" 0.807626079524189 0.952641225877339 0.197708835084032 0.228738397178435 0.832300599419696 -0.817998596226833 0.459481448799723 0.927632358897555 -0.613540769901787 "NRAS MUT" "AZD7762_IC_50" 0.687620227629193 0.911748124009352 -0.121021220105477 0.228917665022378 0.832300599419696 0.294285155869747 0.878355933913441 0.987955687349291 0.0476834398840129 "GNAS MUT" "Cisplatin_IC_50" 0.070212009162529 0.469247157667035 1.06791249616122 0.228976499964475 0.832300599419696 0.613506817712336 0.249303491034421 0.875707386589409 0.650649722306582 "MYCN MUT" "Bryostatin.1_IC_50" 0.0360246894813837 0.347755725308879 0.600401088689402 0.229072521805081 0.832300599419696 0.331908349268598 0.911561270404808 0.990339041794625 -0.0353242734071159 "STK11 MUT" "ABT.888_IC_50" 0.973724511825542 0.995472410100622 -0.00758435895589558 0.229080017558684 0.832300599419696 -0.233630854067098 0.812451189715439 0.977383317127464 -0.0546220946351268 "MLH1 MUT" "CCT018159_IC_50" 0.328458892436137 0.769814166739703 -0.56792480798772 0.229138043641612 0.832300599419696 -0.655504844161053 0.279622862211831 0.88601917827756 -0.629751565786455 "NOTCH1 MUT" "PHA.665752_IC_50" 0.202501129031478 0.674012093366938 -0.513866909722225 0.229425583666112 0.832841472659441 -0.507199734792813 0.0801882796411287 0.741811190933953 -0.831422984692005 "CDH1 MUT" "Sorafenib_IC_50" 0.646773582205718 0.897186614618066 -0.38234301027397 0.229580006997386 0.832841472659441 -0.977248738798327 0.791127267210545 0.975393509832241 -0.233929063066973 "NOTCH1 MUT" "PLX4720_IC_50" 0.321160110916508 0.762015213745527 -0.50779204892368 0.229787821662979 0.832841472659441 0.570013942531529 0.798806484288787 0.976360691959787 -0.129116680313488 "ALK MUT" "BI.D1870_IC_50" 0.120885024071423 0.580044291137328 -1.44363037404582 0.230035249943996 0.832841472659441 -0.968525688753253 0.658881966648202 0.958313128388245 -0.480109570808563 "CDKN2C MUT" "JNJ.26854165_IC_50" 0.202437872580591 0.674012093366938 -0.596267450980389 0.230050898104247 0.832841472659441 -0.529698633728078 0.447927200710731 0.925809648901546 -0.370662206754486 "APC MUT" "Sunitinib_IC_50" 0.192565794465223 0.668037820564704 0.942549999043053 0.23006323635011 0.832841472659441 0.654245986847185 0.229002326088019 0.868145256417768 0.901727584450889 "FGFR3 MUT" "EHT.1864_IC_50" 0.377154679625945 0.795261485512158 0.791293303571426 0.230118399589492 0.832841472659441 1.0675204280737 0.566691730611241 0.949294892873838 0.498017797473448 "CDH1 MUT" "GSK269962A_IC_50" 0.590123127467235 0.876506729771444 -0.561521150684928 0.230227533633362 0.832841472659441 -1.19888087711918 0.105418766222499 0.78806739294782 -1.72109613438916 "MS-HL MUT" "A.443654_IC_50" 0.755925665109035 0.934654823707749 -0.108323495360671 0.2302310092371 0.832841472659441 -0.273889204191868 0.566829014238432 0.949294892873838 -0.230643062971449 "CDKN2a(p14) MUT" "SL.0101.1_IC_50" 0.687650716198628 0.911748124009352 -0.0439398908115105 0.230353319616474 0.832841472659441 -0.118560027324057 0.728190042025046 0.965402608571648 -0.0408814339279109 "MLH1 MUT" "Rapamycin_IC_50" 0.898789349237079 0.978795346528664 0.137505647260274 0.230455179281106 0.832841472659441 -1.12057732064563 0.801339160420548 0.976360691959787 0.279738914939131 "KRAS MUT" "Epothilone.B_IC_50" 0.0316839048962788 0.329006499381264 -0.596705324316328 0.230620761525502 0.832841472659441 -0.199934503434221 0.105780505746146 0.788168661441703 -0.501689247119585 "PIK3R1 MUT" "Camptothecin_IC_50" 0.499219256049563 0.845109283443017 0.540829847408824 0.23064774568036 0.832841472659441 -0.60622433043935 0.985934425467589 0.998124818853736 0.0124116621940756 "NF1 MUT" "BAY.61.3606_IC_50" 0.0143076791946831 0.217579621452021 0.993816966881185 0.230684529869453 0.832841472659441 0.340977333026943 0.0118722782902446 0.459749370120074 1.03672484814894 "VHL MUT" "Erlotinib_IC_50" 0.101438479096396 0.542024654294532 -1.63108474452556 0.230693618144604 0.832841472659441 -1.09080408233175 0.579019684114164 0.949294892873838 -0.561681500579129 "SMO MUT" "FH535_IC_50" 0.172544091955233 0.650961807890931 -1.53491690956522 0.231063416532358 0.833345563001563 -1.149986381904 0.163945108243581 0.839927262232576 -1.49279162495223 "CDH1 MUT" "AICAR_IC_50" 0.240213625564033 0.711340033600749 0.765976506696436 0.231162416222625 0.833345563001563 0.703803109355349 0.387150499758537 0.915785792511616 0.585652844845649 "VHL MUT" "GDC.0449_IC_50" 0.284484221378609 0.740302864659114 0.465738027343748 0.23132788809256 0.833345563001563 0.466352823891635 0.322922250366142 0.900918773778407 0.46219864062119 "GNAS MUT" "KIN001.135_IC_50" 0.145727308667565 0.619919550890177 -0.568112542372883 0.231333275636356 0.833345563001563 -0.456532882090285 0.0975890530735144 0.772625185318248 -0.623337457736089 "MAP2K4 MUT" "MS.275_IC_50" 0.411446392005724 0.812480994891775 -0.906548455326462 0.231374468241448 0.833345563001563 -1.10230575938212 0.62998751334267 0.952523560833852 -0.644171409445343 "PIK3R1 MUT" "Nutlin.3a_IC_50" 0.505316003183586 0.847679261741881 -0.442825600790509 0.231396256993791 0.833345563001563 -0.727965399676222 0.43624255858192 0.922569292988365 -0.498940716736179 "MYCL1 MUT" "Nutlin.3a_IC_50" 0.128629404422846 0.58914788070103 1.07780924823892 0.231560401080521 0.833406339269535 0.775556228946862 0.336445446655195 0.905430766021494 0.726508721025686 "CCND3 MUT" "Etoposide_IC_50" 0.557713447273847 0.86900908342163 -0.720302325259533 0.231600815822229 0.833406339269535 -0.956923883099382 0.401572022700703 0.916589616820582 -0.976825508375655 "NOTCH1 MUT" "Bryostatin.1_IC_50" 0.938741087535871 0.989080507581691 -0.0245642100044563 0.231706151259766 0.833415758038079 -0.370712940571937 0.229648864403384 0.868145256417768 -0.404179245155014 "EWS_FLI1 MUT" "Obatoclax.Mesylate_IC_50" 0.10841547714801 0.554630099396014 -0.966258879003569 0.231791118382396 0.833415758038079 -0.564257308189601 0.857563159385868 0.984898622336936 -0.11850332092047 "FGFR2 MUT" "AKT.inhibitor.VIII_IC_50" 0.00871646317318479 0.164354372486315 2.10120089792386 0.232070202254413 0.834075874168789 0.836458982984058 0.0769817331449597 0.741811190933953 1.59799998644476 "NRAS MUT" "Z.LLNle.CHO_IC_50" 0.0984571038664947 0.536152212572481 -0.677601057489181 0.232162544864908 0.834075874168789 -0.471068900146111 0.33111219942769 0.902810042912437 -0.436659908938992 "CDK4 MUT" "Bexarotene_IC_50" 0.102187819152655 0.542132629566743 -0.9335300632689 0.232386953099221 0.83454449271095 -0.611049136895967 0.402525106192848 0.916850640727267 -0.485171796929043 "APC MUT" "BX.795_IC_50" 1.15122575427844e-06 0.00026215476727556 1.4462346523605 0.232739777598399 0.835221817056195 0.292680543018237 0.199513067094803 0.851001889249827 0.416943120078335 "STK11 MUT" "IPA.3_IC_50" 0.0231645395305336 0.277593371444066 0.975132539481621 0.232763652428114 0.835221817056195 0.431175737873039 0.343466064207145 0.907180409180092 0.403059735028689 "MYCN MUT" "Nilotinib_IC_50" 0.575169839928688 0.872620551543038 0.214523426934984 0.232920641401194 0.835447583313409 0.384654478365678 0.976237794022226 0.99742775226181 -0.0120295780566869 "CDKN2a(p14) MUT" "NVP.BEZ235_IC_50" 0.000361261210824315 0.0243057637373541 -0.501395943556976 0.233430042895707 0.836387967652822 -0.126576842899519 0.332378584339514 0.903405836635744 -0.146048837067589 "EP300 MUT" "ATRA_IC_50" 0.626153684528903 0.891165203894421 -0.486514139579353 0.233460050260524 0.836387967652822 -0.94082752101 0.309972998984863 0.89718581932126 -0.883482660285393 "PIK3CA MUT" "Obatoclax.Mesylate_IC_50" 0.239597074537634 0.711183696179387 -0.386918132426884 0.233465349826748 0.836387967652822 -0.290474609920188 0.0248542873520495 0.571841777133554 -0.775767858434277 "JAK2 MUT" "EHT.1864_IC_50" 0.188645216002577 0.663245512002727 -0.632802870041931 0.233650614732996 0.836610138365353 -0.573070344847221 0.120667464755242 0.80757178183218 -0.790519286837968 "MET MUT" "Bleomycin_IC_50" 0.223536591652734 0.696139064632428 -1.2213627738516 0.233715769990366 0.836610138365353 -0.976466779916916 0.191192351081651 0.851001889249827 -1.26612172050268 "FLCN MUT" "Parthenolide_IC_50" 0.112352697451808 0.563432092377384 1.46578675675676 0.233943383475117 0.836908192286294 1.02024852265844 0.40913517472311 0.920903133902018 1.38463542886525 "KRAS MUT" "X681640_IC_50" 0.0372869226064326 0.351296460573821 0.411768069779923 0.23434320101602 0.836908192286294 0.214264665068734 0.638242856227998 0.953445720127982 0.101848066226493 "ERBB2 MUT" "SL.0101.1_IC_50" 0.506501919663067 0.847796212975596 -0.199303417809811 0.234355068667954 0.836908192286294 -0.320408179422174 0.0629995901549326 0.70501719149803 -0.571257907778357 "PTEN MUT" "Sorafenib_IC_50" 0.143972620634857 0.617457147496601 0.425397546937751 0.234376559662059 0.836908192286294 0.335556571646039 0.0519431058679789 0.690213288728522 0.638256633309754 "PTEN MUT" "FTI.277_IC_50" 0.336872540484724 0.774844944812494 0.122974291466389 0.2345389309993 0.836908192286294 0.141645670693455 0.186848148772971 0.851001889249827 0.174587203201392 "CDK4 MUT" "Vinblastine_IC_50" 0.019243710020981 0.251922457491553 1.33162354296725 0.234576183448671 0.836908192286294 0.490172344941932 0.0150897280010737 0.492634387965361 1.35949104055904 "TET2 MUT" "ZM.447439_IC_50" 0.371703320875332 0.791250525573783 -0.826372024135694 0.234597188949572 0.836908192286294 0.885270377522812 0.381308582774418 0.915134825237766 0.941053947038214 "APC MUT" "ABT.888_IC_50" 0.517587085988806 0.852353345422823 0.126627875000001 0.234609574969885 0.836908192286294 -0.205832897911533 0.534609954239462 0.943443271455699 0.139742625086287 "EP300 MUT" "Vinorelbine_IC_50" 0.157204210999249 0.632778052170647 -1.65651315198614 0.234647156715783 0.836908192286294 -1.02661429855857 0.152247110672865 0.832065593775825 -1.63851988994194 "SMAD4 MUT" "BMS.754807_IC_50" 0.0633122477639583 0.450893824743909 -0.813377170022661 0.234940569099804 0.837618303562969 -0.445440989192152 0.375681168277007 0.914419412871569 -0.40917453097713 "MSH2 MUT" "Midostaurin_IC_50" 0.890428817815594 0.975801867105169 -0.0916398588850169 0.235322072450772 0.838641783882545 0.610996925195607 0.447258027059711 0.925809648901546 -0.463294895193983 "SMAD4 MUT" "Roscovitine_IC_50" 0.727611773658582 0.926041868997115 -0.222846215538847 0.235483209537078 0.838879415924102 0.69510756407467 0.709564839900884 0.962630898212352 -0.252535766993176 "VHL MUT" "Midostaurin_IC_50" 0.0797418358648462 0.490694424776936 -1.16403189285712 0.235711204190987 0.839044971314731 -0.607914448457801 0.555081437161589 0.948071221654821 -0.386753231381844 "JAK2 MUT" "MS.275_IC_50" 0.342935907015939 0.77972703282349 1.20638454452053 0.235718635675065 0.839044971314731 1.23881821244506 0.0502469725862618 0.685473676710585 3.18475308015583 "PIK3CA MUT" "Methotrexate_IC_50" 0.0388915690971062 0.357923342125803 0.69964091634642 0.236035278358563 0.839265047286482 0.309575273691565 0.0609685629370247 0.702860976445846 0.547715050703544 "IDH1 MUT" "BIRB.0796_IC_50" 0.244764404442034 0.713407507663177 -1.00137600000002 0.236047572109607 0.839265047286482 -0.972679161568701 0.32458983551703 0.900918773778407 -0.843819934686805 "ALK MUT" "Vorinostat_IC_50" 0.0292854483516281 0.316403974222396 -1.95018117716533 0.236063966684116 0.839265047286482 -0.812102297054966 0.0730911113134555 0.739487156743738 -1.47118715707383 "CCND3 MUT" "FTI.277_IC_50" 0.418473462139453 0.814099702076568 0.447182484429077 0.236313068399337 0.839814469969793 0.596854547296771 0.152510059031973 0.832990057972293 0.750631675153134 "KDM5C MUT" "AKT.inhibitor.VIII_IC_50" 0.171333569706891 0.649721929411943 1.09818229930798 0.236415050304963 0.839840824703352 0.814474698340491 0.176613498235418 0.848618686837376 1.05611903075236 "NF1 MUT" "CCT018159_IC_50" 0.460289830953061 0.828966839128293 -0.228398803827752 0.236541818257638 0.839955173109189 -0.341688620767016 0.226470728128357 0.866933851943076 -0.40241386025493 "NOTCH1 MUT" "CMK_IC_50" 0.126433364965764 0.587206821914858 -0.800498952472083 0.23698235941254 0.841096500893875 -0.592975433786638 0.0400964568247974 0.650999329179205 -1.26707127257969 "TSC1 MUT" "Epothilone.B_IC_50" 0.785740656431649 0.946106438559363 0.449459516521742 0.237052645168041 0.841096500893875 -1.11397898302771 0.713892630951376 0.962630898212352 0.589689185118571 "BCR_ABL MUT" "KIN001.135_IC_50" 0.380618166261129 0.797609706126731 0.34277322033898 0.237153827346701 0.841119465122225 0.573504573706356 0.986646544262588 0.998124818853736 -0.00625208952513492 "FGFR3 MUT" "CCT007093_IC_50" 0.190079664145107 0.664991779417723 -0.938728124999999 0.237580644704495 0.841488883993699 -0.849313647459333 0.192380474557671 0.851001889249827 -0.942681945182059 "KRAS MUT" "PD.0332991_IC_50" 0.421273760442888 0.815993951252625 0.197858897874247 0.237585719051901 0.841488883993699 -0.250616903582375 0.781344823387627 0.973017078278378 -0.0758385569909409 "STK11 MUT" "VX.702_IC_50" 0.998695859250603 0.999548905963057 0.000533490259739161 0.237670832730184 0.841488883993699 -0.315113265029543 0.422110014721967 0.922428741067589 -0.260256132024185 "PIK3R1 MUT" "EHT.1864_IC_50" 0.320266014977935 0.762015213745527 -0.478633247339573 0.237772609227877 0.841488883993699 -0.563330906234761 0.335801427254933 0.905358978582594 -0.451166499610381 "BRCA1 MUT" "X17.AAG_IC_50" 0.304074234391181 0.753693350719531 1.13162615678777 0.238032844675958 0.841488883993699 1.14402459195869 0.0654827794552069 0.711992560878964 1.77145910498866 "EWS_FLI1 MUT" "Z.LLNle.CHO_IC_50" 0.73056286920386 0.927803352123478 0.192097187559805 0.238659277685955 0.841488883993699 -0.659061298106467 0.74104430510138 0.96672489654949 -0.206770098091906 "FGFR2 MUT" "CCT018159_IC_50" 0.0916931151339343 0.518019437343811 1.68807602739727 0.238747084052 0.841488883993699 1.11527018989602 0.0233545483986378 0.565154616698372 3.22538715027819 "ALK MUT" "AICAR_IC_50" 0.312095087477482 0.759215564942334 -1.2276066731141 0.238972262826148 0.841488883993699 -1.28324481363304 0.236395814268991 0.871856821645725 -1.38906782067826 "IDH1 MUT" "GSK.650394_IC_50" 0.221920210411384 0.694197984755969 -1.79942795130436 0.239018902524138 0.841488883993699 -1.11568313034865 0.32301083591313 0.900918773778407 -1.45849919501461 "EP300 MUT" "Erlotinib_IC_50" 0.668764875272094 0.90648669983081 0.522049745454548 0.239048411539009 0.841488883993699 1.29534856836934 0.405372731918938 0.917928412078554 0.990626062934031 "FLCN MUT" "GDC0941_IC_50" 0.166754853755548 0.646248650615878 1.25961026597938 0.239065512536356 0.841488883993699 0.862318311559226 0.554466496405317 0.948071221654821 0.754135603464076 "RUNX1 MUT" "NVP.BEZ235_IC_50" 0.444375978610762 0.825606373270691 -0.683253798804786 0.239146367837786 0.841488883993699 -0.757143499332903 0.412507723378254 0.921714070263062 -0.689132646326836 "CDK4 MUT" "Midostaurin_IC_50" 0.237883190571264 0.710855542080976 -0.784673595818818 0.239227016409097 0.841488883993699 -0.605674255487053 0.385673766810621 0.915331032347709 -0.556663816582735 "KDM5C MUT" "Bexarotene_IC_50" 0.25506186143756 0.720311238267775 0.916718226876105 0.239230075297122 0.841488883993699 0.845396507379448 0.393000821909971 0.915926348152589 0.655072471746141 "MET MUT" "Cisplatin_IC_50" 0.744528900369245 0.92998047316164 0.157776645067698 0.239365406226807 0.841488883993699 -0.493796118166157 0.749857531814565 0.968780465757047 -0.147723775895453 "APC MUT" "BMS.708163_IC_50" 0.305302206015096 0.754224310561809 0.242684482396749 0.239394168430301 0.841488883993699 0.295883710142439 0.48140855334266 0.930646356603431 0.204815944071659 "TSC1 MUT" "CHIR.99021_IC_50" 0.477430016321393 0.836138034894556 -0.721862017241388 0.239446490864291 0.841488883993699 -1.13347711759999 0.412526897615093 0.921714070263062 -0.801306783440227 "CDKN2A MUT" "Nutlin.3a_IC_50" 0.00618280074624591 0.136590680167686 -0.450838683760682 0.23945397639465 0.841488883993699 -0.185623263370719 0.00617028145891735 0.368388397903175 -0.495722911306211 "MET MUT" "Pyrimethamine_IC_50" 0.142967380504091 0.61606176606809 2.41193647457629 0.239528472325638 0.841488883993699 1.62706301861093 0.154485505797593 0.835611501078903 2.354074056041 "EWS_FLI1 MUT" "NVP.BEZ235_IC_50" 0.362418365030818 0.787270200866664 -0.380787052371253 0.239547347811466 0.841488883993699 0.382529222361031 0.257957552924564 0.877052916121269 0.521583774583165 "FLT3 MUT" "Parthenolide_IC_50" 0.540322077216333 0.861616652986104 0.566328761261266 0.239551832666809 0.841488883993699 1.0181608553584 0.468290834766792 0.929276781658587 0.694121140757096 "KDM6A MUT" "Pazopanib_IC_50" 0.758835955439208 0.934762260113025 0.128591530746832 0.239651455482361 0.841488883993699 0.420881480607742 0.919243779947111 0.993794649720217 0.0410808424555567 "RB1 MUT" "ABT.263_IC_50" 0.0593334861383763 0.439862785571841 -0.589120808373596 0.23994896280513 0.841488883993699 -0.338534624647626 0.169254992067877 0.84067330207935 -0.413562476218513 "GNAS MUT" "AZD.2281_IC_50" 0.0220361516310311 0.271432819188887 1.30155740840671 0.239997798160738 0.841488883993699 0.504863961362896 0.136461726881996 0.830541253822459 0.745964334573123 "CCND1 MUT" "CGP.60474_IC_50" 0.295659913437786 0.747204646998838 0.572736971830984 0.24005249689508 0.841488883993699 0.489422658642787 0.439343946073873 0.923724807074352 0.479598868457743 "PTEN MUT" "GW.441756_IC_50" 0.614653782736215 0.885815598771911 0.076320292657855 0.240103375304361 0.841488883993699 0.179408760330711 0.520480202688097 0.939635632721979 0.104956960380992 "CDH1 MUT" "CEP.701_IC_50" 0.0181538362800514 0.247069557579196 1.55003779966409 0.240118871250448 0.841488883993699 0.572929462769578 0.0975757095445214 0.772625185318248 1.06120700854328 "AKT2 MUT" "TW.37_IC_50" 0.473289158072557 0.834460661638643 -0.39762099396682 0.240216865252394 0.841488883993699 -0.590946812598434 0.215510132947362 0.860576337437605 -0.663736737194893 "FLT3 MUT" "RDEA119_IC_50" 0.0966207688734463 0.530359701114639 2.24739902380947 0.240226991713622 0.841488883993699 1.44886749408342 0.202346420796571 0.852959543285214 1.48221565926427 "CDKN2a(p14) MUT" "PF.562271_IC_50" 0.00345878840229445 0.0955608346705312 -0.386292229087829 0.240325795759031 0.841488883993699 -0.130825551019607 0.202719865139972 0.852959543285214 -0.185288360303788 "ERBB2 MUT" "LFM.A13_IC_50" 0.21993459074969 0.692830939023895 0.333789453781512 0.240350145672626 0.841488883993699 0.309712340327718 0.601675621922788 0.949657634568742 0.150041293302999 "RB1 MUT" "CEP.701_IC_50" 0.05036641188086 0.399494753390785 0.501917257705539 0.240363759757906 0.841488883993699 0.227248008442989 0.131920085162024 0.824721122422311 0.387940547264995 "ALK MUT" "Sunitinib_IC_50" 0.525850307057761 0.854969048950887 0.752590674657535 0.240384787601848 0.841488883993699 1.03071667643922 0.81816600284412 0.977383317127464 0.278856427015144 "STK11 MUT" "AUY922_IC_50" 0.122363506529965 0.580982694522287 0.609337603676917 0.240540021954 0.841700525994276 0.310735943757192 0.229609269660254 0.868145256417768 0.481917980267175 "EZH2 MUT" "BX.795_IC_50" 0.26717084697637 0.730974828095239 -0.889365520325219 0.240796825030267 0.841992793802563 -0.720444836729283 0.115650878558955 0.802355750183445 -1.10776925004865 "IDH1 MUT" "OSI.906_IC_50" 0.382879894889046 0.798569876743396 1.25944640695653 0.240841714198073 0.841992793802563 1.59115964788881 0.315862781139274 0.900294798053993 1.4626572589398 "MSH6 MUT" "PF.562271_IC_50" 0.579178826290345 0.874194311383525 0.302982271777003 0.240907970842508 0.841992793802563 0.520735837966227 0.5616004571505 0.949294892873838 0.309409706428846 "SMAD4 MUT" "ATRA_IC_50" 0.0754583568208651 0.480779116570693 0.605004930973061 0.241075372216413 0.842246412531062 0.323022334179898 0.979983511053262 0.997827228172038 -0.00796220537240245 "BCR_ABL MUT" "PHA.665752_IC_50" 0.146372800315905 0.619919550890177 1.00014807432434 0.241190796175065 0.84231830941044 0.833476902483889 0.207636927164756 0.853446327418758 0.903993233594549 "APC MUT" "GDC.0449_IC_50" 0.303671101640896 0.753234372540836 0.236275789115648 0.241399238846806 0.842714874291856 -0.251916370766811 0.798536150748301 0.976360691959787 0.0703613232643322 "BRCA1 MUT" "GSK.650394_IC_50" 0.122110912746492 0.580982694522287 1.61263870506111 0.241674449901055 0.843344121639005 0.790205501687031 0.245372888438543 0.875707386589409 1.21575485247128 "EGFR MUT" "VX.702_IC_50" 0.692792957770137 0.913066921534475 0.126229161552424 0.241951996763984 0.84395928874445 0.307271235379781 0.568638341085172 0.949294892873838 -0.177432124645995 "BRAF MUT" "NU.7441_IC_50" 0.574671239943467 0.872620551543038 -0.114616668402082 0.242055671861405 0.84395928874445 -0.225618919717217 0.595164564970601 0.949294892873838 -0.124710805610102 "MYCN MUT" "CGP.60474_IC_50" 0.0149427547876311 0.222289121053521 1.01972041073593 0.242135825663873 0.84395928874445 0.377077636434037 0.495659862894776 0.933639405738697 0.336647208027573 "EP300 MUT" "PD.0332991_IC_50" 0.494404327268289 0.843282996121548 -0.954093424742252 0.242303319294846 0.844168747796263 -1.3131144096339 0.469552681043705 0.929276781658587 -0.938503708092916 "ERBB2 MUT" "Cisplatin_IC_50" 0.0191140222270286 0.251111880766628 0.955441008846499 0.242401398885368 0.844168747796263 0.427048146111281 0.199764728902451 0.851001889249827 0.53516443253679 "CDK4 MUT" "AG.014699_IC_50" 0.876076409042548 0.971594429690931 -0.071718331050228 0.242481080467095 0.844168747796263 -0.473348986824936 0.882274271916213 0.988301482344111 0.066076659813209 "GNAS MUT" "QS11_IC_50" 0.782088836232298 0.944314407151708 0.17303965255732 0.242705573692635 0.844619200612966 -0.53692858918333 0.839708488768306 0.981889544272722 -0.12445496251155 "MLL_AFF1 MUT" "AZD.0530_IC_50" 0.640448762731667 0.895951701992251 0.669924986531977 0.242863229655535 0.844709422320144 1.47830839575884 0.738724230164141 0.96672489654949 0.452068797179094 "APC MUT" "VX.702_IC_50" 0.0612863442533385 0.447070552416314 0.518359627891825 0.242921727801559 0.844709422320144 0.274855427170121 0.115537243127868 0.802355750183445 0.498330966306582 "EZH2 MUT" "JNK.9L_IC_50" 0.494364555780433 0.843282996121548 -0.356851533167709 0.243107021675879 0.844984085091964 -0.475073607196067 0.446122344665238 0.925809648901546 -0.424995490816276 "CDKN2a(p14) MUT" "AICAR_IC_50" 0.244168029114953 0.713407040228131 0.180373279524213 0.24329562526676 0.844984085091964 0.168020187650035 0.37218650410862 0.913948248824328 0.147846442125947 "RUNX1 MUT" "BAY.61.3606_IC_50" 0.22959451218223 0.702386793899547 1.03091768181819 0.243331041424361 0.844984085091964 0.694208377389305 0.514142359568695 0.939635632721979 0.584241352940256 "KDM5C MUT" "AZD7762_IC_50" 0.106049347555196 0.549516047897355 -2.0440125219048 0.243467421019797 0.844984085091964 -1.16076199004146 0.0503856534766584 0.686311332095404 -2.23279653315098 "NRAS MUT" "Bleomycin_IC_50" 0.933257126557167 0.987049725015387 0.0442633831775698 0.243476441138423 0.844984085091964 0.520417366440513 0.631126556131509 0.952523560833852 0.279480965046516 "HRAS MUT" "Pazopanib_IC_50" 0.34703992994798 0.782020929432191 0.795541386363628 0.243692864579856 0.84512253479025 0.842690387975634 0.0904064174122159 0.764118629741502 1.30804541287785 "AKT2 MUT" "EHT.1864_IC_50" 0.324889265240731 0.76635898130224 0.559685168539329 0.243706655961922 0.84512253479025 0.654727180975398 0.185089177152393 0.851001889249827 0.736781375242738 "BRCA1 MUT" "AP.24534_IC_50" 0.358720692004436 0.786601117838604 1.14060530606585 0.243900726232927 0.845465397999462 1.30447715379732 0.606705719610467 0.949657634568742 0.603357734018159 "FGFR2 MUT" "A.443654_IC_50" 0.0278326456298987 0.309275185547668 2.57807388168372 0.244041899069359 0.845534794759842 0.913218259471918 0.0379854747975183 0.645472009508728 3.02932530157781 "PDGFRA MUT" "MK.2206_IC_50" 0.452877362103182 0.828509891052426 0.602281497925308 0.244111160203157 0.845534794759842 0.744498840761223 0.436370314250666 0.922569292988365 0.61940771956185 "FLT3 MUT" "AICAR_IC_50" 0.926824824994933 0.98643792569589 0.091201162790698 0.244215726178922 0.845567198516573 1.04568204645701 0.284385916370372 0.8879937007725 1.026042396105 "EWS_FLI1 MUT" "ATRA_IC_50" 0.00742074789384899 0.150464981838523 -1.24685561523438 0.244392652893473 0.845850019620786 -0.459992178010085 0.817126661300629 0.977383317127464 -0.109562624635969 "KRAS MUT" "Erlotinib_IC_50" 0.354287673792104 0.785252181551816 0.369499066147861 0.244533031062376 0.846006174080625 0.451462442899652 0.155253453436309 0.837162064339926 0.616429276731742 "CTNNB1 MUT" "GDC.0449_IC_50" 0.293750363528762 0.747036827777118 -0.360171854043397 0.244749688572302 0.846025977829932 -0.355861769815513 0.200396345412279 0.851001889249827 -0.475218365450136 "MLLT3 MUT" "GNF.2_IC_50" 0.360708464713181 0.786783098836476 0.368404709790208 0.244778433893906 0.846025977829932 0.443417394461706 0.352310089638053 0.91110953125066 0.402004488672041 "KDM5C MUT" "FH535_IC_50" 0.173536613016591 0.65113493295882 1.08473827574173 0.244824542621656 0.846025977829932 0.795772036866536 0.328414876204185 0.902810042912437 0.743442980391265 "KDM6A MUT" "PAC.1_IC_50" 0.456810331860926 0.828966839128293 0.285459280661187 0.245048995573213 0.84647224025115 0.375330827716161 0.201863883368319 0.852068986784239 0.499722461221976 "EGFR MUT" "Roscovitine_IC_50" 0.538160582442295 0.860998762866154 -0.331202269503547 0.24551304992419 0.846930536246489 -0.546551685186835 0.911026253495835 0.990184036004226 -0.0607474412577334 "NF2 MUT" "PD.0325901_IC_50" 0.825449279095853 0.957177484110155 -0.110433754850089 0.245696912032399 0.846930536246489 0.553224423121357 0.444660454499028 0.925809648901546 0.357857037311029 "MYC MUT" "BI.2536_IC_50" 0.790424308328666 0.94790644179192 0.128326376373626 0.245755974067954 0.846930536246489 0.341654196932049 0.762378688323343 0.969901216545994 -0.160585947295837 "MSH6 MUT" "AZD6482_IC_50" 0.436721269098946 0.823808548892323 0.544307544425086 0.245775688882086 0.846930536246489 0.684604154018631 0.452344406383048 0.925809648901546 0.510465478088608 "CCND1 MUT" "Thapsigargin_IC_50" 0.932027922923961 0.98681842896288 0.0483811274074072 0.245794508958213 0.846930536246489 -0.50563535667861 0.633509059965195 0.952523560833852 -0.281801767003007 "PIK3R1 MUT" "DMOG_IC_50" 0.0621566376532811 0.448539201336004 1.26759453416152 0.245794558155977 0.846930536246489 0.709709481207613 0.144251180175941 0.831473272394224 0.933085372664221 "NF1 MUT" "OSI.906_IC_50" 0.727606349375177 0.926041868997115 -0.151071347826087 0.2458492199576 0.846930536246489 -0.477210163414037 0.838026771318153 0.981704379975756 0.0963714804081204 "MYCL1 MUT" "Midostaurin_IC_50" 0.319823372619425 0.761692510655166 0.592682544405589 0.246271884767673 0.847178450065805 0.531959527345173 0.604162895914687 0.949657634568742 -0.306769938688881 "PDGFRA MUT" "BIBW2992_IC_50" 0.15188911636144 0.625830613280407 1.21995023854962 0.246319115554261 0.847178450065805 0.946783766266318 0.882781424293076 0.988301482344111 0.117834977245535 "TET2 MUT" "JW.7.52.1_IC_50" 0.285488945329995 0.740302864659114 -1.66572221088437 0.246389694389872 0.847178450065805 -1.10664799170263 0.195100495214586 0.851001889249827 -2.50014084945355 "IDH1 MUT" "CCT018159_IC_50" 0.139363510492464 0.608499182243643 -1.48007465753425 0.246432653363639 0.847178450065805 -1.07301035864528 0.171106561538074 0.842832361237713 -1.3922476937631 "MSH6 MUT" "Parthenolide_IC_50" 0.299029823114845 0.750344870252218 -0.832735406779655 0.24645542282368 0.847178450065805 -0.865343044308082 0.285288709714513 0.8879937007725 -0.874884346829358 "PIK3R1 MUT" "Paclitaxel_IC_50" 0.0444126311804077 0.376863927777587 2.35327330136985 0.246493538449504 0.847178450065805 0.590611080110338 0.0356289022674589 0.626574813935252 2.4328041397444 "CDKN2A MUT" "BIBW2992_IC_50" 0.656530079853597 0.901751651084414 0.0736019888991288 0.246717036039036 0.847618567529082 0.191369629566991 0.89799561795788 0.988526046030225 0.0222881226485962 "IDH1 MUT" "AP.24534_IC_50" 0.474336288509648 0.834460661638643 1.40237665517243 0.246853570114564 0.847683973235306 2.03619847975213 0.229559321803627 0.868145256417768 2.2270676173142 "EZH2 MUT" "Dasatinib_IC_50" 0.654021294354915 0.900904870244158 0.882023938356165 0.246926972048163 0.847683973235306 -1.88117456890783 0.640708562535014 0.955103296458244 0.916903382636493 "ALK MUT" "PF.562271_IC_50" 0.449061964924946 0.827410645331628 0.822727308620686 0.247169782208392 0.847725052035632 1.02985589304415 0.420313004640166 0.922428741067589 1.21147679719992 "KDR MUT" "X17.AAG_IC_50" 0.362335092264261 0.787270200866664 -1.15719213422393 0.247195267439357 0.847725052035632 -1.29289738960316 0.774016483796855 0.971458506585624 -0.323626114616105 "MLL_AFF1 MUT" "Doxorubicin_IC_50" 0.236960792515992 0.7095832316724 -1.6325327530435 0.24722529949018 0.847725052035632 1.01210245894271 0.570056407494996 0.949294892873838 -0.751524521157605 "NOTCH1 MUT" "AZD.2281_IC_50" 0.00725219209411281 0.148564082327393 -1.08576234591015 0.247360842160961 0.847862462073136 0.368935464816272 0.720927146195587 0.965402608571648 -0.138420885470048 "SMAD4 MUT" "AS601245_IC_50" 0.813476691507418 0.953913887475092 0.0809837126856287 0.247632298656556 0.848259508801071 0.327426032332042 0.329106192914465 0.902810042912437 0.355467210005023 "NF2 MUT" "Lapatinib_IC_50" 0.00222296177637288 0.0710148328631926 -1.73918654609929 0.247777303460984 0.848259508801071 -0.589371350369241 0.231051603969777 0.869110247715201 -0.661688166960482 "BRAF MUT" "ATRA_IC_50" 0.0993709122896066 0.5374999166548 0.404552093997295 0.247784383392944 0.848259508801071 0.246149008471036 0.820445159860861 0.977383317127464 0.0583408344001992 "KDM5C MUT" "Embelin_IC_50" 0.516663766137574 0.852353345422823 -0.465743734729501 0.247858734977906 0.848259508801071 -0.664299078587565 0.428951950288609 0.922428741067589 -0.559931846931548 "TP53 MUT" "AZD.0530_IC_50" 0.635368231911333 0.894673421215244 -0.115412425247236 0.248181863402538 0.84848107607178 -0.26158290955309 0.278056064069725 0.885412658660176 -0.272032944992276 "KDR MUT" "Temsirolimus_IC_50" 0.274153141709998 0.73402283606276 -1.44318203929025 0.248218155665843 0.84848107607178 -1.16453480976473 0.293505351928741 0.894167310052 -1.32965632238061 "EZH2 MUT" "Lenalidomide_IC_50" 0.384212943001422 0.798569876743396 0.414913454198477 0.248272616131949 0.84848107607178 0.480725365996398 0.306841038426485 0.896682870760742 0.465825608054979 "MYC MUT" "Roscovitine_IC_50" 0.468548824362872 0.831405016816516 0.253445363295881 0.24830563187823 0.84848107607178 0.363515515718676 0.575663710567642 0.949294892873838 0.206797318196438 "EGFR MUT" "Bleomycin_IC_50" 0.19006657770783 0.664991779417723 0.919030452048345 0.248488888607838 0.848694122782111 0.663286461530113 0.260291601470181 0.877052916121269 0.800058661220627 "KDM6A MUT" "TW.37_IC_50" 0.577467217441782 0.873750949722175 0.211548932625997 0.24856174310329 0.848694122782111 0.397661511854583 0.365095816358052 0.913900497593792 0.330292827930296 "BRCA2 MUT" "AZD7762_IC_50" 0.0217102232070543 0.269285603773532 1.83894897509578 0.248654668109341 0.848694122782111 0.728889174953733 0.114128145712429 0.799692247086917 1.1645615574893 "PIK3R1 MUT" "Shikonin_IC_50" 0.980381939111923 0.996332002460735 0.0191279090683235 0.248937472763808 0.848986300868727 -0.75365957525814 0.939156249400223 0.994831655017307 -0.0577097737684157 "MDM2 MUT" "Bosutinib_IC_50" 0.0306279140377146 0.324590100917593 1.2377540696325 0.249082769962492 0.848986300868727 0.543734211029382 0.027516826742876 0.588860092297546 1.16110833815818 "VHL MUT" "CGP.60474_IC_50" 0.604114448824729 0.881814764520839 -0.434889195876292 0.249263495308954 0.848986300868727 -0.7378504366673 0.947993762960877 0.995668765770473 -0.062344846999533 "FLT3 MUT" "NVP.BEZ235_IC_50" 0.119204856775403 0.577057450057752 1.39066651992033 0.249342208504628 0.848986300868727 0.750768559557752 0.0549287906454787 0.697305726351784 1.63266919047586 "ALK MUT" "A.770041_IC_50" 0.99321958716851 0.998970779334534 0.0109397542662109 0.249460489471082 0.848986300868727 -1.21786415376294 0.901668217117837 0.988746233284632 -0.17663581497828 "EP300 MUT" "Embelin_IC_50" 0.282738340987054 0.739072441127871 -0.88975779907084 0.249471699852159 0.848986300868727 -0.763180217674317 0.337452998379161 0.905687542642891 -0.781701751014213 "EP300 MUT" "ABT.263_IC_50" 0.121461796616438 0.58088433804555 1.94866313307243 0.249513077032545 0.848986300868727 1.30764845807346 0.195621710611395 0.851001889249827 1.40462691134501 "SMAD4 MUT" "Mitomycin.C_IC_50" 0.215005572746617 0.688556914357028 -0.523202864460111 0.249582259943694 0.848986300868727 -0.390277231923246 0.234268205037881 0.869962136993019 -0.524023594738545 "APC MUT" "ATRA_IC_50" 0.00265541328692737 0.079403115828963 0.955636262952108 0.249684312090393 0.848986300868727 0.304039766288005 0.0831440432165218 0.745860856369627 0.595273052311566 "JAK2 MUT" "Cytarabine_IC_50" 0.895891855876734 0.977117518088203 0.0987798390804593 0.249751177512517 0.848986300868727 -0.656587616753605 0.648967193621186 0.957493413330814 0.346311063272069 "EWS_FLI1 MUT" "SL.0101.1_IC_50" 0.515605353357023 0.852353345422823 0.214307844513047 0.249791825714445 0.848986300868727 0.349067291912571 0.118239103041553 0.806524749270063 0.573510373608654 "GNAS MUT" "Tipifarnib_IC_50" 0.92570543744402 0.98643792569589 0.0665945696649024 0.249909705548783 0.848995515424432 -0.545926669147815 0.9458712719657 0.995668765770473 0.0480820423770328 "AKT2 MUT" "ABT.263_IC_50" 0.647331865605397 0.897186614618066 -0.447234113555988 0.250038127406335 0.848995515424432 -1.0121890057578 0.341474652106475 0.907180409180092 -0.814192449417093 "ALK MUT" "CCT007093_IC_50" 0.278304171153483 0.736660995953974 -0.776908928571427 0.250165499441075 0.848995515424432 -0.828776047593796 0.354800760310643 0.91161229252998 -0.680735002742658 "PDGFRA MUT" "GW.441756_IC_50" 0.335430961714288 0.773264085106582 0.526248360687026 0.250176924205128 0.848995515424432 0.612469037030801 0.419930033700475 0.922428741067589 0.443666068971509 "TSC1 MUT" "AMG.706_IC_50" 0.536224032477912 0.859994020980345 0.561861738281243 0.250419112900469 0.849283030619728 0.962346996051418 0.355129327271496 0.91161229252998 0.773021321365196 "APC MUT" "QS11_IC_50" 0.571267269547834 0.872389778906173 -0.204985960475005 0.250829889469303 0.849283030619728 -0.318700826763285 0.492246033997703 0.933639405738697 -0.29540578581587 "MS-HL MUT" "Paclitaxel_IC_50" 0.690358868699198 0.912906062078257 0.176332662451363 0.250862282803735 0.849283030619728 0.224862494372063 0.922743590435957 0.993931766508607 0.048697297351568 "ERBB2 MUT" "BMS.509744_IC_50" 0.25137614257759 0.717470497840808 1.15170568027211 0.25092744563992 0.849283030619728 0.869578642555876 0.544855979946771 0.946853280734584 0.613336544891466 "CDH1 MUT" "QS11_IC_50" 0.93809550840834 0.98883650048509 0.0511710831377152 0.251116549399678 0.849283030619728 -0.563767280291412 0.731352931730588 0.96639568318693 -0.236398914702427 "MYCN MUT" "BIRB.0796_IC_50" 0.968913271645269 0.994856543446662 -0.0105533879164313 0.251254771980819 0.849283030619728 0.308411478960271 0.935469142094215 0.994729228933513 -0.0263318280396611 "EWS_FLI1 MUT" "AUY922_IC_50" 0.109666953457727 0.557499836095061 -0.791603577105583 0.251288177545835 0.849283030619728 -0.407223466381877 0.367756388352014 0.913948248824328 -0.486764326222122 "RB1 MUT" "BIBW2992_IC_50" 0.144306080105633 0.617666544298534 -0.384923737316053 0.251321124642031 0.849283030619728 -0.29699363061658 0.0157950299683888 0.506009605077458 -0.648920191607592 "MDM2 MUT" "MS.275_IC_50" 0.680788849733733 0.909596174888715 0.40699850689655 0.251461726468308 0.849283030619728 0.939863535285926 0.622353197137738 0.950496524771391 0.506972776184101 "NRAS MUT" "Midostaurin_IC_50" 0.352766361016249 0.785062892590933 0.278037756878308 0.251491089047176 0.849283030619728 0.27210002063942 0.581463767991855 0.949294892873838 0.171492682100972 "SETD2 MUT" "AMG.706_IC_50" 0.39027948015696 0.801837403580487 0.780261542968738 0.251521802582618 0.849283030619728 0.965255505991226 0.441554259053411 0.924472815010418 0.644542117367389 "TSC1 MUT" "BIRB.0796_IC_50" 0.48770175845936 0.841054887180408 0.597692571428586 0.251528504092622 0.849283030619728 0.94850451888325 0.376944810698767 0.914419412871569 0.751569296947825 "MET MUT" "Gemcitabine_IC_50" 0.36821748534109 0.789246419666677 -1.10979147574688 0.251691720171195 0.849283030619728 -0.948160496186756 0.188063655540624 0.851001889249827 -1.52295623966299 "MLLT3 MUT" "Methotrexate_IC_50" 0.691270425418394 0.912932803156675 -0.21119368184955 0.251764759564545 0.849283030619728 -0.463156307950081 0.434896192603042 0.922569292988365 -0.346087220827195 "SMO MUT" "Temsirolimus_IC_50" 0.160980346032971 0.636336191287136 2.26275887855787 0.251958614830629 0.849283030619728 1.4064113521524 0.299354241343937 0.894167310052 1.58399287026179 "BRCA2 MUT" "AZ628_IC_50" 0.900089285027488 0.97933285041609 0.240355683673469 0.252018109420499 0.849283030619728 -1.63982880012635 0.705768670336562 0.962630898212352 -0.633408593044522 "MSH6 MUT" "AZD7762_IC_50" 0.287584907240293 0.742453942209604 -0.722848910164829 0.252071663178397 0.849283030619728 -0.608260501798203 0.313517824184338 0.900294798053993 -0.620256795222569 "KIT MUT" "Nilotinib_IC_50" 0.270609110988032 0.733000988154624 -0.905418760952386 0.252108756244441 0.849283030619728 -0.763502283597058 0.216729962934655 0.860576337437605 -0.920136292549192 "AKT2 MUT" "Mitomycin.C_IC_50" 0.126457708514938 0.587206821914858 -1.28651602330828 0.252203623238944 0.849283030619728 -0.75336857005674 0.0324269061378641 0.618827479917328 -1.76980042819249 "MSH2 MUT" "Rapamycin_IC_50" 0.483996200404643 0.83936150279118 0.951835250847455 0.252248704339318 0.849283030619728 1.33985041369437 0.421366952132593 0.922428741067589 1.12264612051783 "TET2 MUT" "VX.680_IC_50" 0.875971824493793 0.971594429690931 -0.238125316268484 0.252335627494677 0.849283030619728 1.14794786420672 0.994414152089164 0.999545005862799 0.0134543820159909 "CDKN2a(p14) MUT" "GDC0941_IC_50" 0.578607844671228 0.874062981548763 -0.0939524310124556 0.252438966563199 0.849283030619728 0.161342978062559 0.579276531798837 0.949294892873838 0.10413295782065 "BRCA1 MUT" "ATRA_IC_50" 0.0802170901089641 0.492069006956693 1.51248746168581 0.252461119337471 0.849283030619728 0.781632217656525 0.126323792662643 0.817150972850516 1.15472072247345 "BRCA2 MUT" "Temsirolimus_IC_50" 0.022200155339682 0.271944247685126 2.33779740839698 0.252867966041759 0.850223664957031 0.901235316501955 0.2564289410042 0.875707386589409 1.11370858111794 "SETD2 MUT" "A.443654_IC_50" 0.387848814134363 0.799926920187478 1.24175834693878 0.253098457165765 0.850223664957031 1.07799159071274 0.210077140260119 0.854647312253832 1.8578611937456 "NF2 MUT" "Vorinostat_IC_50" 0.38024636951323 0.79739504312798 0.253277805102043 0.253141689063607 0.850223664957031 0.253026832473377 0.510256927387571 0.938422873866617 0.185278248839305 "IDH1 MUT" "Metformin_IC_50" 0.286555849801793 0.741305709900881 -1.08671159695816 0.253156061157481 0.850223664957031 -1.08024230803191 0.0872721589705038 0.755326311453013 -1.71910585731728 "RB1 MUT" "S.Trityl.L.cysteine_IC_50" 0.073791088010222 0.478349381473563 -0.613754234120781 0.25339525460697 0.850223664957031 -0.22085871167003 0.0275946909801071 0.58910685239022 -0.90040247108542 "FLCN MUT" "FTI.277_IC_50" 0.758851338542409 0.934762260113025 -0.15193118544194 0.25342117345892 0.850223664957031 -0.514105437294013 0.437067546184873 0.922569292988365 -0.469087528126664 "EGFR MUT" "GDC.0449_IC_50" 0.697173091805819 0.914698512088563 0.101411600909806 0.25353114784481 0.850223664957031 0.266714520594858 0.950401071598192 0.995668765770473 -0.0168316337067258 "AKT2 MUT" "Camptothecin_IC_50" 0.170879811463041 0.649721929411943 1.26230503887826 0.253553161333349 0.850223664957031 0.664670588940143 0.214818024424858 0.859434499119166 1.0173083184345 "KRAS MUT" "BMS.708163_IC_50" 0.516703833167248 0.852353345422823 0.0979938997105036 0.253625218316032 0.850223664957031 0.184476945188557 0.785904681961186 0.974807190013589 0.0482492572661058 "ALK MUT" "Gemcitabine_IC_50" 0.566761733244629 0.872389778906173 -1.64420998608697 0.253777412791004 0.850223664957031 -2.19235767738955 0.336994571053447 0.905430766021494 -3.63495784518458 "MET MUT" "GW843682X_IC_50" 0.796950187843889 0.949420392411711 0.445170644067798 0.253793822294909 0.850223664957031 -1.01145588386389 0.703673952214292 0.962139809888331 0.682528510066528 "FLT3 MUT" "XMD8.85_IC_50" 0.80761065499021 0.952641225877339 -0.257275841924396 0.254075060841063 0.850813726986864 1.05072344444786 0.42562457795179 0.922428741067589 0.832548756504331 "EGFR MUT" "Docetaxel_IC_50" 0.62047717935107 0.887709137927527 -0.19496295582329 0.254300670380492 0.850813726986864 -0.33775438437864 0.800835726001693 0.976360691959787 -0.100396711064826 "VHL MUT" "NVP.BEZ235_IC_50" 0.097117368301424 0.531422888407237 -0.911141286720309 0.254329136289739 0.850813726986864 -0.4552245322198 0.368684367368096 0.913948248824328 -0.50901276780712 "HRAS MUT" "WO2009093972_IC_50" 0.114191365374574 0.566238702340366 -1.09373188863107 0.254419032173564 0.850813726986864 -0.712761006788763 0.267760810618365 0.877052916121269 -0.757582128212498 "EWS_FLI1 MUT" "MS.275_IC_50" 0.292353524028509 0.746948114757534 0.709151812419963 0.254454044671033 0.850813726986864 0.692747108501693 0.695890968470752 0.961100601384891 0.314257619882236 "NOTCH1 MUT" "MG.132_IC_50" 0.974081518472285 0.995601684471241 0.0236015026924295 0.254544766648361 0.850813726986864 -0.762381298022244 0.150659087384108 0.831473272394224 -1.11760819168494 "APC MUT" "Temsirolimus_IC_50" 2.045740755177e-06 0.00042251682899365 1.98354360713823 0.25500084889026 0.852017509027239 0.38482322916111 0.0428855606348833 0.658180729724545 0.994892963147525 "FBXW7 MUT" "MS.275_IC_50" 0.0143670079866021 0.217736173940295 -1.6417827922535 0.255150070946792 0.852051178042536 -0.650868216897844 0.0331980741055042 0.618827479917328 -1.54488332713167 "BRCA1 MUT" "Cyclopamine_IC_50" 0.213265272501834 0.687763182315503 1.30381575342467 0.255220673704715 0.852051178042536 1.09367819406616 0.250127237508261 0.875707386589409 1.2231792283376 "ERBB2 MUT" "BI.D1870_IC_50" 0.013106456166604 0.207480784061478 0.981452390196075 0.255334146166212 0.852051178042536 0.402438698765715 0.278498371350775 0.885713545160236 0.43471072782565 "MSH2 MUT" "RO.3306_IC_50" 0.246420201209554 0.714668105985286 0.647930989010981 0.255396589825238 0.852051178042536 0.607086886737371 0.381682466269789 0.915134825237766 0.492509193583707 "PDGFRA MUT" "BAY.61.3606_IC_50" 0.72208136080804 0.923635973690941 0.305380531468532 0.255490630236153 0.852051178042536 0.676168816100685 0.942462116758376 0.995314665488626 0.0591506642676976 "TSC1 MUT" "Bosutinib_IC_50" 0.133202226504244 0.599882846645128 -1.90988486476195 0.255648805072526 0.852258647841255 -1.19096593895746 0.269238583194148 0.878819138279722 -1.29902880914724 "KRAS MUT" "Midostaurin_IC_50" 0.418813330195196 0.814099702076568 0.179935339268291 0.25621659309049 0.853830980576601 0.206047324521394 0.277364387176299 0.884414807088842 0.251674573129693 "SMARCA4 MUT" "AZD7762_IC_50" 0.273976112844442 0.73402283606276 0.623916871179883 0.256441616224929 0.8539995202776 0.503331512510461 0.19651016339527 0.851001889249827 0.764714176931425 "KRAS MUT" "GNF.2_IC_50" 0.507063581134989 0.847796212975596 0.180526902532249 0.256545223978088 0.8539995202776 0.311490130813387 0.150335708147232 0.831473272394224 0.435475644956888 "KRAS MUT" "CGP.082996_IC_50" 0.498177566553528 0.845109283443017 0.240473701226309 0.256555649149942 0.8539995202776 0.363146009870897 0.404447358149359 0.917353377955789 0.320724853719408 "ERBB2 MUT" "ZM.447439_IC_50" 0.122446658728847 0.580982694522287 0.608173899041304 0.256797893203859 0.854485608671216 -0.368101711578944 0.908697745659789 0.989594687823984 0.0456028475447225 "KDM6A MUT" "ZM.447439_IC_50" 0.0434334855117757 0.374825086237107 -0.77291207885305 0.257149423214922 0.855147243731903 -0.348794566762552 0.0205229046641242 0.537651670566628 -0.863240529886281 "BRAF MUT" "Elesclomol_IC_50" 0.840475055115148 0.959424448728358 -0.0624544650556202 0.257239229911553 0.855147243731903 -0.319826909580546 0.266645018218095 0.877052916121269 -0.388219068121796 "SMAD4 MUT" "CMK_IC_50" 0.0371640845337056 0.351296460573821 -1.35648517647059 0.257353496015283 0.855147243731903 -0.70032944427458 0.0593349941132928 0.70215997387469 -1.32937229361368 "MLH1 MUT" "FH535_IC_50" 0.261486486705268 0.724288808298587 0.520510263126848 0.257381891959844 0.855147243731903 0.455315291866308 0.240288160764863 0.875707386589409 0.52454995377114 "MDM2 MUT" "PD.0325901_IC_50" 0.281985861688536 0.738375640008268 0.812500574966532 0.257864547924429 0.856312488987642 0.802955446274459 0.419590024892564 0.922428741067589 0.530588001275807 "SETD2 MUT" "Epothilone.B_IC_50" 0.589944730078386 0.876506729771444 0.890939777391318 0.257992360050975 0.856312488987642 -1.07713693319365 0.422941827165081 0.922428741067589 1.29322946959124 "CDKN2C MUT" "XMD8.85_IC_50" 0.413732191255454 0.813205638306533 -0.613473784722223 0.258021869218661 0.856312488987642 -0.736154685320361 0.678819484779867 0.961100601384891 0.371259774319564 "CTNNB1 MUT" "Z.LLNle.CHO_IC_50" 0.171552164517068 0.649721929411943 -1.02217758735633 0.258140821912208 0.856387239223877 -0.77200982350273 0.279036171391584 0.885713545160236 -0.876350157006903 "MET MUT" "OSI.906_IC_50" 0.511545783465897 0.849960356026311 0.407249305171862 0.258357336240414 0.85678547541117 0.66423557438438 0.469181664494706 0.929276781658587 0.451973744753412 "CCND1 MUT" "Nilotinib_IC_50" 0.0155862304324374 0.227586688087166 0.809674390873021 0.258634186583538 0.857357332699942 0.309573425325914 0.11398024311069 0.799692247086917 0.514087529697547 "CTNNB1 MUT" "A.443654_IC_50" 0.79411895462158 0.948646027682356 0.218278144827589 0.258722852340485 0.857357332699942 0.608494783175762 0.537100510082009 0.943443271455699 0.585915231662772 "NRAS MUT" "CEP.701_IC_50" 0.00351529682702262 0.0963814374491735 -0.90383353751742 0.258945814971539 0.857474960981116 -0.2654193457827 0.133382631059902 0.826060771578096 -0.480714531563542 "ALK MUT" "AZ628_IC_50" 0.139335821046237 0.608499182243643 -2.31040460409555 0.259096202475584 0.857474960981116 -1.31193768173717 0.0053729217813473 0.358956332448686 -4.58646724961503 "MYCN MUT" "AG.014699_IC_50" 0.0343631195414709 0.342467578391929 -0.77264707638889 0.259106713782502 0.857474960981116 -0.384642850842528 0.534101880956358 0.943443271455699 -0.265186509899472 "MSH6 MUT" "GDC0941_IC_50" 0.417700991507494 0.814099702076568 0.738744606185552 0.259218534998553 0.857474960981116 0.82683651410307 0.514699804801253 0.939635632721979 0.587714047152086 "ERBB2 MUT" "Paclitaxel_IC_50" 0.30744401452226 0.755781746844506 -1.54113444217687 0.259265891529578 0.857474960981116 -0.760279662912661 0.52426775486275 0.940554660491705 -0.986053955848764 "NF2 MUT" "IPA.3_IC_50" 0.161903926064175 0.637610023074489 0.641284704179519 0.259453299834949 0.857474960981116 0.438126394739272 0.477942738708828 0.930304161706959 0.326191636575688 "SMO MUT" "SB.216763_IC_50" 0.302892922181006 0.752537231223384 -1.06168799220273 0.259592001622601 0.857474960981116 -1.11641866136265 0.120641460118211 0.80757178183218 -1.53644909871137 "TP53 MUT" "LFM.A13_IC_50" 0.418029188518435 0.814099702076568 0.0788071083366895 0.259624957858884 0.857474960981116 0.1085105777657 0.654598805440023 0.958313128388245 0.0468000119940377 "EWS_FLI1 MUT" "CEP.701_IC_50" 0.00673236637629216 0.142357489971073 -1.35066539140086 0.259716037879961 0.857474960981116 -0.451117640446504 0.830325595438159 0.981482581683432 -0.11221790766549 "CDKN2C MUT" "BI.D1870_IC_50" 0.241063157139155 0.711340033600749 -0.671717971579958 0.259723864997095 0.857474960981116 -0.559112879252916 0.373468455025434 0.913948248824328 -0.518000393877365 "EWS_FLI1 MUT" "DMOG_IC_50" 0.928146202793608 0.986689293492114 -0.0422234920634913 0.260116893367661 0.857533374460696 0.50948387974158 0.159892779256648 0.838901067822678 0.707475695394908 "RUNX1 MUT" "Obatoclax.Mesylate_IC_50" 0.766982826641115 0.937850808294193 -0.306541839160842 0.260142636621116 0.857533374460696 -0.852801408186755 0.121147400385356 0.809563628910719 -1.70686579833943 "SETD2 MUT" "PHA.665752_IC_50" 0.20710503002296 0.680161611517635 -1.22492842281878 0.260242124366776 0.857533374460696 -1.09937605170296 0.420459025639941 0.922428741067589 -0.809918251588808 "MYCL1 MUT" "Pyrimethamine_IC_50" 0.350492213216961 0.784966682190403 0.894600549828187 0.260256190550316 0.857533374460696 0.923417478992742 0.767738305017439 0.969901216545994 0.295778376905991 "CCND1 MUT" "AKT.inhibitor.VIII_IC_50" 0.308816330660309 0.75674113273833 0.321037479279281 0.260297365369151 0.857533374460696 0.307755176622934 0.265466417665524 0.877052916121269 0.367942459018426 "KDM5C MUT" "RDEA119_IC_50" 0.431210565029601 0.820918238409269 1.06584088888887 0.260340919086467 0.857533374460696 1.37611309607541 0.476666433189368 0.929855889225741 0.818699424885255 "NRAS MUT" "GSK.650394_IC_50" 0.854305218765144 0.964541653680809 -0.0612385782821535 0.260417465479169 0.857533374460696 0.250230883044175 0.918152216009504 0.992963223576061 0.0390020471715931 "EZH2 MUT" "EHT.1864_IC_50" 0.229720020593624 0.702528754439386 0.762378139013466 0.260563190399892 0.857625472711635 0.704324130225954 0.310298948905877 0.89718581932126 0.625578368090776 "BRAF MUT" "Docetaxel_IC_50" 0.696791410547928 0.914682004129471 -0.100418227174976 0.260745129323207 0.857625472711635 -0.239901411960566 0.380020153387181 0.915134825237766 -0.260548294825013 "NOTCH1 MUT" "X681640_IC_50" 0.0812979733650825 0.495483837022832 -0.769635929907926 0.260911783866496 0.857625472711635 0.440839296990275 0.352166527517774 0.91110953125066 0.420581215523947 "PIK3R1 MUT" "PD.0325901_IC_50" 0.181315300437916 0.658636992153339 1.0693226513026 0.260979639398437 0.857625472711635 0.844845356079529 0.289083923879428 0.889281028047524 0.739593374328886 "PDGFRA MUT" "Obatoclax.Mesylate_IC_50" 0.627506168895049 0.891518522789462 0.501940069930071 0.261028488196791 0.857625472711635 0.853663303785565 0.549106586130694 0.947060194029534 0.604243403293188 "AKT2 MUT" "WO2009093972_IC_50" 0.290014658274299 0.745349408181059 0.733199155452429 0.261235726174429 0.857625472711635 0.694898632067751 0.380959074414194 0.915134825237766 0.603605513162122 "CDKN2A MUT" "Parthenolide_IC_50" 0.602757085045086 0.880745626033854 -0.100509122238587 0.261253700985837 0.857625472711635 0.214612690874739 0.546298413521451 0.946853280734584 0.139139051105143 "MS-HL MUT" "LFM.A13_IC_50" 0.683519658922037 0.910505188373572 0.0578431501768805 0.261323002548624 0.857625472711635 0.151014629136922 0.927005783532688 0.994186152404781 0.0144168471625902 "KDR MUT" "ABT.888_IC_50" 0.24151998508947 0.711340033600749 0.716483637404588 0.26156912170157 0.857625472711635 0.579492668827583 0.341190658429351 0.907180409180092 0.550588035014323 "EP300 MUT" "AP.24534_IC_50" 0.146146583111241 0.619919550890177 2.32631547495676 0.261628084517584 0.857625472711635 1.62472246544714 0.086465296413904 0.751368197115344 2.56536320230133 "SMARCB1 MUT" "Thapsigargin_IC_50" 0.917075946784118 0.984975746996111 0.212225401739132 0.261682937859186 0.857625472711635 1.73982103622698 0.671553085969237 0.960241983012847 0.850324295065186 "STK11 MUT" "Mitomycin.C_IC_50" 0.86482915057141 0.967489995749939 0.0786537796865582 0.262254362263806 0.857625472711635 -0.405797198872055 0.867251683156287 0.987077901072027 0.079900551491678 "MAP2K4 MUT" "XMD8.85_IC_50" 0.292091049584652 0.746611418788718 -0.964768344827597 0.262394812454824 0.857625472711635 -0.88210731020559 0.395738679147411 0.916003810456352 -0.891451570348818 "CCND3 MUT" "ABT.263_IC_50" 0.192340853648308 0.668037820564704 2.00780207226559 0.262652372170299 0.857625472711635 1.55121454701396 0.389468537133315 0.915926348152589 1.14451909562141 "BCR_ABL MUT" "XMD8.85_IC_50" 0.254182226997758 0.719602281787404 -1.04399627586208 0.262679781700993 0.857625472711635 1.11836217014899 0.722526232785306 0.965402608571648 -0.325556868922124 "BCR_ABL MUT" "Lapatinib_IC_50" 0.154034807309913 0.629826484217006 1.27611364583333 0.262758928813923 0.857625472711635 1.11822931965996 0.266708662868761 0.877052916121269 0.888157258989852 "KDM6A MUT" "Metformin_IC_50" 0.0223072250200853 0.272504078959254 -0.833393359375008 0.262824324677139 0.857625472711635 -0.384430009640756 0.0681378596298987 0.719539038493615 -0.675336879997428 "EZH2 MUT" "Parthenolide_IC_50" 0.0684751902942595 0.463159303125148 1.45811137288136 0.262886951492123 0.857625472711635 0.832164840830184 0.0571382400134694 0.700127165484445 1.79359882021438 "MSH6 MUT" "NSC.87877_IC_50" 0.254799260425647 0.720311238267775 -0.453589024390243 0.262916593043734 0.857625472711635 -0.437643229773944 0.240906040978599 0.875707386589409 -0.471022461759264 "MLH1 MUT" "BI.2536_IC_50" 0.0255535692147978 0.297432828566998 1.80752751124569 0.263040477463132 0.857625472711635 0.544721743361131 0.0376620980061084 0.645472009508728 1.76918470776265 "PIK3R1 MUT" "Etoposide_IC_50" 0.0218727731397349 0.270169816764932 2.1303567681988 0.263083786309596 0.857625472711635 0.677255137735198 0.0257364647550457 0.578646945543191 1.955348066279 "CCND3 MUT" "MK.2206_IC_50" 0.924496505513751 0.98643792569589 -0.11989447010309 0.263146073423456 0.857625472711635 -1.12936205806891 0.920771389974292 0.993931766508607 -0.122079334204325 "FLT3 MUT" "FH535_IC_50" 0.351336527672882 0.784966682190403 -0.743176074171045 0.263332890490192 0.857625472711635 -0.772506150500771 0.20122906963859 0.851001889249827 -0.981851792500992 "ALK MUT" "Roscovitine_IC_50" 0.226740828574524 0.699276507734018 1.17181614763553 0.263369694288153 0.857625472711635 0.958090935556864 0.0560419421175949 0.697813103075383 2.2681599687407 "KDM6A MUT" "Tipifarnib_IC_50" 0.220810698669346 0.693711036770013 -0.608933966598155 0.2633808576734 0.857625472711635 -0.372017158934286 0.169223970905074 0.84067330207935 -0.712414633735606 "CDH1 MUT" "AZD6482_IC_50" 0.648796509458517 0.898481490800108 -0.300823618964516 0.263383059767893 0.857625472711635 -0.631897941937736 0.479637651128635 0.930304161706959 -0.48825767717075 "KDM6A MUT" "Lapatinib_IC_50" 0.171647705195914 0.649721929411943 -0.689770959470631 0.263505764641704 0.857625472711635 -0.484374067733683 0.667637771869682 0.959230524020512 -0.209096951732011 "GNAS MUT" "BIBW2992_IC_50" 0.460585249377466 0.828966839128293 -0.498442108925139 0.263614444528079 0.857625472711635 -0.722366671525853 0.995411061074073 0.999545005862799 -0.00358510491322081 "MYC MUT" "BX.795_IC_50" 0.76152601941057 0.93574319967042 -0.081842401746725 0.263673016651168 0.857625472711635 -0.233286862813346 0.56837032206203 0.949294892873838 -0.14227647000389 "TET2 MUT" "FTI.277_IC_50" 0.0464822931159306 0.384030826498868 1.26776895682207 0.263690105853425 0.857625472711635 0.657073846203421 0.147478155097368 0.831473272394224 1.07366048574599 "SETD2 MUT" "Thapsigargin_IC_50" 0.123913981366151 0.58411893233163 3.13284888000003 0.263737381910657 0.857625472711635 1.74596375296711 0.133337167483701 0.826060771578096 2.9724239415413 "AKT2 MUT" "CEP.701_IC_50" 0.102909621673611 0.543688489044222 1.23493918769917 0.263742672626137 0.857625472711635 0.620636772322099 0.246651831188621 0.875707386589409 0.802462348335708 "PTEN MUT" "AP.24534_IC_50" 0.689028884842939 0.912098006601601 0.128757141205156 0.263760498130636 0.857625472711635 0.33185024905199 0.290305203683486 0.891022884087089 0.348156533704045 "FBXW7 MUT" "GW.441756_IC_50" 0.295039876926072 0.747036827777118 0.271416839920947 0.263765852687599 0.857625472711635 0.284646510385559 0.344817425748264 0.908328790918938 0.257245782335486 "TET2 MUT" "WZ.1.84_IC_50" 0.465652264773847 0.830246489350841 -0.709046803185432 0.263836941877863 0.857625472711635 -0.911965912692009 0.601812961852645 0.949657634568742 -0.587944852592283 "CTNNB1 MUT" "Pyrimethamine_IC_50" 0.380516089626822 0.797583996218033 0.840354673539526 0.264061275889052 0.857625472711635 0.896318244489686 0.229951912906855 0.868283562298375 1.28355304892898 "SMARCA4 MUT" "Z.LLNle.CHO_IC_50" 0.126809857774197 0.587206821914858 1.60537458361773 0.264215718904607 0.857625472711635 1.08234876563771 0.679555141319608 0.961100601384891 0.72736834374763 "VHL MUT" "A.443654_IC_50" 0.341827080818831 0.778773897785973 0.868842481099661 0.26422235574347 0.857625472711635 0.677069198238901 0.0636166072645966 0.70501719149803 2.02009495535386 "TP53 MUT" "Temsirolimus_IC_50" 0.674147370126629 0.908418658675584 -0.0883520115241388 0.264281626241682 0.857625472711635 -0.187192536487624 0.0765018769544289 0.741811190933953 -0.378996015851074 "PDGFRA MUT" "X681640_IC_50" 0.247497341189219 0.714668105985286 0.847212106122447 0.264308176873296 0.857625472711635 0.69910932607439 0.623970959953711 0.950496524771391 0.342681180056622 "PDGFRA MUT" "Gefitinib_IC_50" 0.207576968653346 0.681008887554625 0.918784925572522 0.264652733765191 0.858429849732892 0.732119527993425 0.985938926830016 0.998124818853736 -0.0117620785143192 "CTNNB1 MUT" "Obatoclax.Mesylate_IC_50" 0.792964542185562 0.948304071878264 -0.158148134045079 0.264918114052229 0.858976915260258 0.491996866553282 0.85404141063762 0.984631915507353 0.119460830484094 "BRAF MUT" "Vinblastine_IC_50" 0.684953252941161 0.910911925631994 0.10324028807058 0.265089892293318 0.859220194692319 -0.22624083356219 0.215631985803751 0.860576337437605 -0.352547422455057 "CCND3 MUT" "AZD6482_IC_50" 0.305998591746524 0.754830733680498 -1.00945342041525 0.265401435556369 0.859699941161579 -0.928165393919544 0.477913402130354 0.930304161706959 -0.684153239122952 "PIK3CA MUT" "Tipifarnib_IC_50" 0.117673905597433 0.573824271985386 -0.500129397599323 0.265431509814779 0.859699941161579 -0.239267074759474 0.0657321186778615 0.711992560878964 -0.634949625026574 "CCND1 MUT" "FTI.277_IC_50" 0.287524120251064 0.742453942209604 0.230854941741743 0.265620339602825 0.859771951169494 0.221896503158938 0.0960568094704301 0.77097828178369 0.367375776658744 "VHL MUT" "CCT018159_IC_50" 0.386488433526873 0.79929668582732 0.466546717255043 0.265647363361006 0.859771951169494 0.559001026078432 0.264104613929701 0.877052916121269 0.615271860346721 "SMO MUT" "AG.014699_IC_50" 0.368694822988036 0.789246419666677 0.915680383408062 0.266018337409704 0.860658963400939 0.993619392648024 0.682588854166559 0.961100601384891 0.384320302942816 "NF2 MUT" "Erlotinib_IC_50" 0.00781722199352395 0.156071611661099 -1.46383146816479 0.2662275569876 0.860840038330135 -0.572673135481882 0.322511837362085 0.900918773778407 -0.587869992900857 "MYCN MUT" "BI.2536_IC_50" 0.0574232890330978 0.430359687681807 0.97255991925466 0.266308028138046 0.860840038330135 0.348193989246689 0.954129216132637 0.99568364368633 0.0368961425191822 "FGFR2 MUT" "Methotrexate_IC_50" 0.302027550599291 0.752400189866003 1.61924706412828 0.266501613679416 0.860840038330135 1.33365417608804 0.300900101298196 0.894167310052 1.81446044604891 "AKT2 MUT" "Bosutinib_IC_50" 0.972100302292312 0.995220468612913 -0.0258088976327558 0.266603688392371 0.860840038330135 -0.672240332070142 0.786711798448096 0.975087420732438 -0.186272968873907 "EP300 MUT" "BAY.61.3606_IC_50" 0.260114656010647 0.723255560435365 1.24542962369337 0.266619294203925 0.860840038330135 0.857366998206991 0.403087855987808 0.916962922394397 0.863784055243107 "RB1 MUT" "Tipifarnib_IC_50" 0.189918740576018 0.664991779417723 0.383549818834135 0.266655888463709 0.860840038330135 0.221955194970036 0.941213883391406 0.995296816798845 -0.0241197011996831 "MLH1 MUT" "AKT.inhibitor.VIII_IC_50" 0.359019670792536 0.786601117838604 -0.428301300000001 0.266759340919984 0.860861085287201 -0.449137216831545 0.243258286702727 0.875707386589409 -0.535670072889604 "MYCN MUT" "Cisplatin_IC_50" 0.610933921541993 0.884818029552257 0.197082619917439 0.266894005482275 0.860982805190004 0.385498102809265 0.707734279022047 0.962630898212352 0.163189257514948 "NOTCH1 MUT" "VX.702_IC_50" 4.39986677267842e-05 0.00563774002198538 -1.64532769810268 0.267146974713985 0.861485941334385 -0.385365942114556 0.0217681101625763 0.549211893050681 -0.940680019721512 "BRCA2 MUT" "Cisplatin_IC_50" 0.633392771499597 0.89399270048764 0.355343727099241 0.267364480685047 0.861874393090345 -0.717010486160313 0.695316457243959 0.961100601384891 -0.28220666274215 "BRCA1 MUT" "X681640_IC_50" 0.932533127411346 0.98681842896288 0.0693170458248468 0.267543731293352 0.862139287959455 -0.778952700528757 0.799585675708937 0.976360691959787 -0.194413594182339 "EZH2 MUT" "QS11_IC_50" 0.358356851902349 0.786601117838604 -0.684756573684219 0.267803810175229 0.86266435914625 -0.604718194286313 0.508502131952355 0.938147991955214 -0.518096123487568 "MYCN MUT" "CMK_IC_50" 0.927690827009133 0.986593180452362 -0.0350912914285716 0.268121969980342 0.863148645033007 -0.402797307720994 0.107664462620965 0.792785095696032 -0.765750713141528 "AKT2 MUT" "Midostaurin_IC_50" 0.0624742705185832 0.449811681617198 -1.32166292248449 0.26823864045894 0.863148645033007 -0.604974992886164 0.0390930726427507 0.64992634601437 -1.34615126730831 "TSC1 MUT" "Nilotinib_IC_50" 0.205728335011138 0.678793564970003 -1.46770396963946 0.268379932097547 0.863148645033007 -1.0433459220012 0.570069404488975 0.949294892873838 -0.591996068903787 "CTNNB1 MUT" "Salubrinal_IC_50" 0.238332332539767 0.710855542080976 -0.835563091118806 0.268416703208675 0.863148645033007 -0.640686367583874 0.600263087205818 0.949657634568742 -0.411059840866098 "VHL MUT" "Metformin_IC_50" 0.262689279159119 0.724847082936025 0.574319038461541 0.268440103319577 0.863148645033007 0.531737150239504 0.835737121692158 0.981626636221501 0.113103533171263 "CCND3 MUT" "AKT.inhibitor.VIII_IC_50" 0.23876046875169 0.710855542080976 -0.945974387543277 0.268811616382184 0.863202118678311 -0.762870983157999 0.431590771379397 0.922569292988365 -0.617609828864261 "CDK6 MUT" "AS601245_IC_50" 0.218466302438905 0.692186668555089 0.788724513181022 0.26883116816579 0.863202118678311 0.568343487704532 0.269406954413181 0.878819138279722 0.748354106509422 "APC MUT" "AZD7762_IC_50" 0.0199309925741952 0.255421565730776 0.768237913306459 0.268873795459963 0.863202118678311 -0.299957045103209 0.342618256416187 0.907180409180092 0.351173767423918 "BRCA2 MUT" "Camptothecin_IC_50" 0.636363689760266 0.895223495764442 0.477335120229013 0.268899465672408 0.863202118678311 -0.709451593722607 0.377071661830574 0.914419412871569 -0.794361450711903 "KDM6A MUT" "CEP.701_IC_50" 0.772019207622229 0.940249942799371 -0.135817373538011 0.268942716178683 0.863202118678311 0.38177706333155 0.475942674113073 0.929855889225741 -0.313474520564322 "PDGFRA MUT" "EHT.1864_IC_50" 0.264580859404962 0.72664811065258 -0.634159775280899 0.269076225365926 0.863318626255344 -0.624877393469438 0.178022751640306 0.848722027112292 -0.75544251866615 "CCND1 MUT" "BMS.754807_IC_50" 0.244591442732588 0.713407040228131 0.527718573131312 0.269575762268874 0.864295248020539 0.419505677632126 0.547745318883564 0.947060194029534 0.286877813753181 "STK11 MUT" "AKT.inhibitor.VIII_IC_50" 0.581364069732897 0.875991568255491 -0.184050254928318 0.269593497091955 0.864295248020539 -0.316797651139358 0.712863850140237 0.962630898212352 0.127739347993376 "FAM123B MUT" "Cisplatin_IC_50" 0.0343789697416134 0.342467578391929 1.75698542476192 0.269699692046261 0.864295248020539 0.793597626276305 0.186907130331768 0.851001889249827 1.06738441762236 "CDKN2A MUT" "OSI.906_IC_50" 0.816689384394128 0.955165737441734 0.0397524211017051 0.26976989387602 0.864295248020539 0.187866849115466 0.922767936318324 0.993931766508607 -0.0191141716979847 "SMO MUT" "DMOG_IC_50" 0.616536727345244 0.885815598771911 0.634822931034495 0.26991829883119 0.864458857526071 1.25197022797292 0.830949792092474 0.981482581683432 0.254280840363941 "EWS_FLI1 MUT" "BI.2536_IC_50" 0.0548971117650831 0.418465152800335 1.33362560139862 0.270199320798631 0.8650469243016 0.496068259005569 0.281858301371131 0.887872038823822 0.893815356973796 "VHL MUT" "Tipifarnib_IC_50" 0.981100760448659 0.99647253585825 0.0188812021089632 0.2708281408243 0.866395264123395 0.586401163306488 0.883510037587027 0.988301482344111 -0.12456929123922 "CCND1 MUT" "JNK.9L_IC_50" 0.137189065432237 0.604353219297467 0.401947796396399 0.270904199298844 0.866395264123395 0.235132563696465 0.20652799373307 0.853446327418758 0.363401625219476 "FLCN MUT" "AZD8055_IC_50" 0.200129682189272 0.674012093366938 0.912246636182909 0.270952933574511 0.866395264123395 0.609345088121207 0.246172145809835 0.875707386589409 1.1260924436919 "MLLT3 MUT" "Doxorubicin_IC_50" 0.958989446943095 0.993456347206305 0.0222910343439538 0.271146112840381 0.866395264123395 0.2967888569177 0.451405456711929 0.925809648901546 0.324543207365493 "TET2 MUT" "AMG.706_IC_50" 0.822914249649758 0.957085051223088 -0.166177736464451 0.271228421844885 0.866395264123395 0.762621843359883 0.196004094759918 0.851001889249827 1.08748998691712 "MSH2 MUT" "BMS.509744_IC_50" 0.400974178580692 0.806415132522709 -0.599692714776636 0.271356397829548 0.866395264123395 -0.585924466835154 0.821560978471961 0.97739893500462 -0.161598378590161 "NF1 MUT" "PF.4708671_IC_50" 0.228780225977763 0.700881583834069 0.302491237851665 0.271370020284243 0.866395264123395 0.273622962217619 0.259583259541733 0.877052916121269 0.305583925670112 "PDGFRA MUT" "NU.7441_IC_50" 0.394513521284536 0.803226635150841 -0.547302194444448 0.271400926110943 0.866395264123395 -0.619488743413575 0.502027641500237 0.934042323734638 -0.422032368698077 "KRAS MUT" "KU.55933_IC_50" 0.00152470164782337 0.0569603689624804 0.47274391876751 0.271924447220803 0.867754587052803 0.154761619578152 0.116088475245919 0.802355750183445 0.270965821690373 "SETD2 MUT" "GNF.2_IC_50" 0.0906054653656459 0.515812267892501 -1.50165773129252 0.27210332698066 0.868013522598867 -0.941582001342415 0.336668326603888 0.905430766021494 -0.877012628033963 "FAM123B MUT" "GSK.650394_IC_50" 0.919408065802911 0.985846509832088 -0.0945803531468519 0.272268195732994 0.868113806953488 -0.662411748501441 0.996052713105281 0.999545005862799 -0.00466781117046372 "CCND3 MUT" "AUY922_IC_50" 0.455718042997294 0.828966839128293 -0.708510479057606 0.272440376952154 0.868113806953488 -0.70057935191411 0.573493313968412 0.949294892873838 -0.511293036682993 "CCND3 MUT" "JNJ.26854165_IC_50" 0.386586824326695 0.79929668582732 -0.698717668161441 0.272491284977657 0.868113806953488 -0.825508741784115 0.353966486799129 0.911252930312559 -0.703615811700646 "KIT MUT" "TW.37_IC_50" 0.0838236424550975 0.500295367140933 -1.16977883333334 0.272580419762856 0.868113806953488 -0.676427057161077 0.0982177688263293 0.774133667469059 -1.07994563412904 "TP53 MUT" "Imatinib_IC_50" 0.675025220135231 0.908552538148308 -0.0701968154935034 0.272623511720896 0.868113806953488 -0.195215706981988 0.244371283912453 0.875707386589409 -0.225325298048268 "AKT2 MUT" "AUY922_IC_50" 0.578044642424425 0.873750949722175 -0.40048703233083 0.272802204312748 0.868127114753604 0.530370631922497 0.495799733100874 0.933639405738697 -0.474185622462123 "RB1 MUT" "Erlotinib_IC_50" 0.195050143776681 0.670441006096806 0.369153253826276 0.272984431707798 0.868127114753604 0.28853601089898 0.860844016242508 0.985524480087535 0.0569521678616119 "JAK2 MUT" "AP.24534_IC_50" 0.0723918798324426 0.475175376786343 1.88838430310564 0.273067103644609 0.868127114753604 1.03831244659472 0.224706816100814 0.86643108387559 1.30595969835046 "FLT3 MUT" "Gemcitabine_IC_50" 0.460757451798894 0.828966839128293 -1.49953118150091 0.2732679847141 0.868127114753604 1.51284388158232 0.776992619230974 0.972337708041191 -0.543047600817627 "CDKN2a(p14) MUT" "MS.275_IC_50" 0.519406397765533 0.852599738673405 -0.176536603789563 0.273279302451913 0.868127114753604 0.266547195393058 0.565673636989372 0.949294892873838 -0.18631249263889 "EZH2 MUT" "Bryostatin.1_IC_50" 0.563749088851041 0.871754997395969 -0.276711512030079 0.273380776754836 0.868127114753604 -0.492805870323811 0.710497516906224 0.962630898212352 -0.183058791890726 "SMAD4 MUT" "ABT.263_IC_50" 0.0694091097408804 0.466280108629924 0.793812798392183 0.273385942637335 0.868127114753604 0.440799717454693 0.534025602995013 0.943443271455699 0.25169082637533 "MLL_AFF1 MUT" "Imatinib_IC_50" 0.0649606396823564 0.457143772598262 -1.81596259259257 0.273519657212562 0.868127114753604 -1.08887855268863 0.119582626992361 0.807345933536413 -1.62474094590667 "KIT MUT" "Etoposide_IC_50" 0.144307765984707 0.617666544298534 -1.60456874870016 0.273622482346047 0.868127114753604 -0.78791199080416 0.151057975423745 0.831473272394224 -1.49729237455995 "FLT3 MUT" "AZD8055_IC_50" 0.269118779851472 0.732006752858616 0.907881503968231 0.273761590513124 0.868127114753604 0.7072822611536 0.0735807291916091 0.740896208560862 1.4266357510697 "ERBB2 MUT" "Camptothecin_IC_50" 0.00199175144461769 0.0662499796990626 1.70485982548253 0.273868777289383 0.868127114753604 0.394184514970374 0.357491784389752 0.91161229252998 0.479680336740588 "MYC MUT" "BMS.754807_IC_50" 0.502374945412223 0.846565396668817 -0.244736281073078 0.273895844872696 0.868127114753604 -0.336368754751588 0.150612623533747 0.831473272394224 -0.543399097653826 "EP300 MUT" "AUY922_IC_50" 0.24714491395949 0.714668105985286 -1.26779628977931 0.273921564193381 0.868127114753604 -0.806830028623441 0.323912782859353 0.900918773778407 -1.02698524376005 "BRCA1 MUT" "BIBW2992_IC_50" 0.581245853420337 0.875991568255491 -0.524962200476199 0.274016136090875 0.868127114753604 -1.00618466950795 0.410128581811628 0.921181571843468 -0.72126129231877 "IDH1 MUT" "SB.216763_IC_50" 0.246985673322786 0.714668105985286 1.19286756335283 0.27409846134156 0.868127114753604 1.08241774644673 0.508741018415059 0.938147991955214 0.661600489529218 "IDH1 MUT" "Methotrexate_IC_50" 0.398869892171961 0.805918367644724 1.32381770541083 0.274249110136397 0.868127114753604 1.29838556757376 0.554943596797727 0.948071221654821 0.739335690167002 "SMO MUT" "Bicalutamide_IC_50" 0.309219948575628 0.75674113273833 0.446614139130437 0.274310233806439 0.868127114753604 0.454825799272481 0.158871647291382 0.83854630828105 0.577070836213054 "NF1 MUT" "Lapatinib_IC_50" 0.27474493939135 0.73402283606276 0.551460901571544 0.274387209899039 0.868127114753604 0.476465967201502 0.65572249867201 0.958313128388245 0.2249944381947 "CDKN2C MUT" "Pyrimethamine_IC_50" 0.225817276073797 0.698134056525989 1.15997838487973 0.27456864317253 0.868391780632207 0.886597079584008 0.805509950360421 0.977152556911746 0.287724537920937 "MSH6 MUT" "Gefitinib_IC_50" 0.965575009936665 0.994434372972651 -0.026663495621237 0.275003390472862 0.869457141612492 0.605602687748082 0.805115038835446 0.976878758490379 -0.136610389080191 "PIK3CA MUT" "WO2009093972_IC_50" 0.33665677109787 0.774572223865332 -0.230775947603124 0.275340088681503 0.870211860348906 -0.237389914684026 0.394465085535663 0.915926348152589 -0.221276073187014 "PIK3R1 MUT" "Elesclomol_IC_50" 0.84379971173576 0.960498931426639 -0.15289801055662 0.275586605946263 0.870681126790739 -0.70261513125343 0.661032506254952 0.958689538788368 -0.320291923454858 "MLL_AFF1 MUT" "Epothilone.B_IC_50" 0.354394942540388 0.785252181551816 -1.53065396173915 0.27587017618025 0.870885049064899 1.0435454386897 0.319421521948176 0.900918773778407 -1.61560519644971 "FGFR2 MUT" "QS11_IC_50" 0.0378890878500923 0.352922011796915 2.03901095637 0.275885586097988 0.870885049064899 -0.800693247016863 0.165611497363331 0.84067330207935 1.53357270177725 "CDKN2a(p14) MUT" "A.770041_IC_50" 0.000306104663417539 0.0215755199667553 -1.12973731865979 0.275945335893326 0.870885049064899 -0.294122661220646 0.150617579268367 0.831473272394224 -0.49038501865827 "CDKN2A MUT" "Lapatinib_IC_50" 0.0107674256598082 0.184249532340571 -0.552038989361703 0.276133468402972 0.870972787792929 -0.217516437402243 0.586076805060881 0.949294892873838 -0.120494101147953 "EWS_FLI1 MUT" "BIBW2992_IC_50" 0.0681363293299299 0.462100070236188 0.935619280166455 0.276169279408275 0.870972787792929 0.57181721945844 0.199695529531383 0.851001889249827 0.70194020027608 "RB1 MUT" "Metformin_IC_50" 0.029110301143971 0.316210068663154 -0.436340388848125 0.276286023231436 0.871031655065099 -0.208549440493227 0.00354684632676748 0.307545333416453 -0.631250359851951 "FGFR2 MUT" "OSI.906_IC_50" 0.0501080168658376 0.398392473033632 2.00017191797559 0.276419137554479 0.871142072612251 1.06798612163971 0.139139045415292 0.831473272394224 1.74961289488012 "FBXW7 MUT" "BI.2536_IC_50" 0.0228870339902018 0.27616813704753 -1.65285244599304 0.276723272511614 0.871602019802461 -0.480753754995586 0.0129069212436779 0.477665075882967 -1.93318492108607 "MLLT3 MUT" "Metformin_IC_50" 0.234063640116906 0.707628390886945 0.40014876434702 0.276761366495095 0.871602019802461 0.340082288499547 0.235544483340621 0.870162461126479 0.409859115421542 "TET2 MUT" "Dasatinib_IC_50" 0.201049835237847 0.674012093366938 2.89697762229804 0.276894159097923 0.871711104909131 2.05103706318246 0.627524988476122 0.952105511848497 -1.16861484865371 "MLLT3 MUT" "AICAR_IC_50" 0.722374712580007 0.923705342742609 -0.14616763140386 0.277219035027345 0.872424610233114 -0.398386060209218 0.85022400225714 0.984453468864253 -0.0784959605255587 "FLCN MUT" "AMG.706_IC_50" 0.174293588171528 0.651792962633888 0.873699725490198 0.277437010556444 0.872690257628506 0.643025523071978 0.766492989219414 0.969901216545994 0.248326635528706 "CDK4 MUT" "Axitinib_IC_50" 0.0892753243568818 0.514272513671442 0.963446882466284 0.277640550234428 0.872690257628506 0.521217323075896 0.166563252952796 0.84067330207935 0.722464717947926 "BCR_ABL MUT" "PD.0325901_IC_50" 0.11301281239923 0.563938179281427 -1.78512310139168 0.277673881828442 0.872690257628506 -1.40824000559733 0.0472231262590075 0.673636396626734 -2.01765984373195 "VHL MUT" "ABT.263_IC_50" 0.731880367412657 0.928176068595523 -0.265603036561254 0.278010546846986 0.872690257628506 -0.761750343350913 0.32055046748196 0.900918773778407 -0.72449484478931 "KRAS MUT" "Cytarabine_IC_50" 0.171067263707879 0.649721929411943 0.319720572366001 0.278142426361132 0.872690257628506 -0.202943979218276 0.290730891463296 0.891022884087089 0.265524670552927 "ERBB2 MUT" "GW843682X_IC_50" 0.382312291498718 0.798569876743396 -1.23555583333333 0.278204788081629 0.872690257628506 -0.806264921395075 0.46418136017621 0.929276781658587 -1.10104766459817 "NOTCH1 MUT" "PD.0332991_IC_50" 0.0317265702967082 0.329006499381264 -1.14533063545756 0.278329194906162 0.872690257628506 -0.479612347122903 0.974976907600944 0.99742775226181 -0.0170822661626966 "EP300 MUT" "S.Trityl.L.cysteine_IC_50" 0.0898542223670949 0.514272513671442 -2.50519905782313 0.278448792043615 0.872690257628506 -0.875188504903731 0.0782672088036215 0.741811190933953 -2.64630302242498 "PTEN MUT" "Lenalidomide_IC_50" 0.307469817740029 0.755781746844506 -0.134965948604992 0.278722065717068 0.872690257628506 -0.128738331931765 0.0431342634136916 0.658180729724545 -0.278148325304929 "APC MUT" "PF.4708671_IC_50" 0.158985288980883 0.635726407671869 0.322658452380954 0.278755166307337 0.872690257628506 0.258800618575662 0.0957205967865789 0.77097828178369 0.470005203286793 "VHL MUT" "IPA.3_IC_50" 0.36081214901452 0.786783098836476 -0.671343961335675 0.278761840381441 0.872690257628506 -0.671482837013042 0.100730574827578 0.774133667469059 -1.21349288913891 "CTNNB1 MUT" "KIN001.135_IC_50" 0.127246655664746 0.587259147140593 -0.487835039817979 0.278782062756467 0.872690257628506 -0.336936172952522 0.107641104581093 0.792785095696032 -0.535982419750353 "MYCN MUT" "Sorafenib_IC_50" 0.296712270175098 0.747966539904914 0.436652953933748 0.278958164423365 0.872690257628506 0.4454439964083 0.520295408694109 0.939635632721979 -0.330043152668834 "SMAD4 MUT" "Bleomycin_IC_50" 0.186534687918818 0.662380873013605 -0.829518694059911 0.279018546794644 0.872690257628506 -0.569283838948349 0.611348765591105 0.949930222127033 -0.330414441901532 "KDM6A MUT" "FH535_IC_50" 0.405227007621252 0.807904911469051 0.294076873672492 0.279255056211882 0.872690257628506 0.329072595910021 0.332792487112225 0.903569160603576 0.346920330520493 "MSH2 MUT" "Bryostatin.1_IC_50" 0.334909582480761 0.773264085106582 0.462089555388477 0.279401917945267 0.872690257628506 0.492023458189848 0.875608328613906 0.987838063957761 0.0723922287725249 "ERBB2 MUT" "Bortezomib_IC_50" 0.450864033198204 0.828077050034054 0.765361323024058 0.279412256717393 0.872690257628506 0.918776167921292 0.447284842989832 0.925809648901546 0.766382747664334 "FLCN MUT" "CHIR.99021_IC_50" 0.127215357238958 0.587259147140593 0.981884038128243 0.279485801226513 0.872690257628506 0.659561988058957 0.520813872310623 0.939635632721979 0.51313982403134 "FGFR3 MUT" "BMS.509744_IC_50" 0.050553865035297 0.400507471345649 -2.39529933898306 0.279494868881906 0.872690257628506 -0.981056606003737 0.0757189200789025 0.741811190933953 -2.14183987485848 "ALK MUT" "Parthenolide_IC_50" 0.405036588325807 0.807904911469051 0.769904662162167 0.27949622792837 0.872690257628506 0.928013241748959 0.441785983576434 0.924472815010418 0.897395705415118 "CCND2 MUT" "WO2009093972_IC_50" 0.27919026183262 0.737723509472033 1.18150063594471 0.279532592715625 0.872690257628506 1.05096057546387 0.51899947496613 0.939635632721979 0.695756040708278 "FGFR2 MUT" "EHT.1864_IC_50" 0.272652808338914 0.734000646544246 0.982643749999999 0.279647085000969 0.872690257628506 0.973387008711243 0.0169481166792723 0.513211661128791 2.92678300331199 "RUNX1 MUT" "Midostaurin_IC_50" 0.154718889855587 0.630721638230745 1.193250084922 0.279700833871291 0.872690257628506 0.697088553928837 0.343406821772404 0.907180409180092 0.80285386344127 "AKT2 MUT" "CI.1040_IC_50" 0.164295796921504 0.640241760623025 1.02020297884615 0.27989744650978 0.872690257628506 0.707883799167647 0.405217467905896 0.917928412078554 0.542922688369051 "TP53 MUT" "BMS.536924_IC_50" 0.224217029480644 0.696139064632428 0.36341406751951 0.280064196762775 0.872690257628506 0.251668468157766 0.469314644747842 0.929276781658587 0.226064991347309 "VHL MUT" "BIBW2992_IC_50" 0.242997834365616 0.712490868125953 -0.788360508157368 0.280077756820109 0.872690257628506 -0.704332893952298 0.146109430584143 0.831473272394224 -0.982504986421545 "KRAS MUT" "GSK269962A_IC_50" 0.196912433696889 0.673125220809113 0.660038145454546 0.280134551158498 0.872690257628506 0.5553903124202 0.656275403624552 0.958313128388245 0.25000652459198 "ALK MUT" "WZ.1.84_IC_50" 0.975234554589184 0.996210959202501 0.0261849999999995 0.280269193581811 0.872690257628506 -0.765514314092304 0.261012220199223 0.877052916121269 -1.05191639959523 "RB1 MUT" "QS11_IC_50" 0.617157206485211 0.886315192560666 -0.128215844808159 0.280432209651958 0.872690257628506 -0.208851270598258 0.361801525156459 0.91161229252998 -0.259039992519134 "PTEN MUT" "Cyclopamine_IC_50" 0.195715147051938 0.671358138651319 -0.298908571428574 0.280451693787543 0.872690257628506 -0.232710367336864 0.645968884252697 0.957098708883585 -0.116789264582509 "VHL MUT" "PF.4708671_IC_50" 0.554152434181083 0.866925654369292 0.264735941043087 0.280568691868943 0.872690257628506 0.476253350212425 0.579163526522477 0.949294892873838 0.255247229605633 "CCND1 MUT" "Docetaxel_IC_50" 0.246515538890831 0.714668105985286 -0.429087741414144 0.280632107061348 0.872690257628506 -0.301733548552045 0.441957586695371 0.924472815010418 -0.296275947414805 "STK11 MUT" "BMS.509744_IC_50" 0.501550630978596 0.846336909314253 -0.524870582191777 0.280668978253855 0.872690257628506 -0.626157858449237 0.247809847264026 0.875707386589409 -1.00950656461685 "SETD2 MUT" "AZD6244_IC_50" 0.522892918286113 0.853786180965717 -1.0140023010309 0.28096449602007 0.872690257628506 -1.57523108193042 0.53803478026131 0.943765926032134 -0.874056471903668 "MLL_AFF1 MUT" "WH.4.023_IC_50" 0.693999864598798 0.913368820021033 0.991164510204084 0.280981239237255 0.872690257628506 2.41561482346162 0.713291387800759 0.962630898212352 0.868181635683745 "MLL_AFF1 MUT" "CEP.701_IC_50" 0.106116430823552 0.549516047897355 -2.11128100948765 0.281097347751625 0.872690257628506 -1.05288657108159 0.877988462732748 0.987889970547261 -0.184272731436781 "FGFR2 MUT" "PD.0332991_IC_50" 0.179522997072813 0.658614416960816 1.87280601855668 0.281101866557458 0.872690257628506 1.21138607850231 0.165309297595792 0.84067330207935 2.55391751684726 "NF1 MUT" "JNK.Inhibitor.VIII_IC_50" 0.796131921068866 0.949180774736554 -0.0629356262939961 0.281153207251035 0.872690257628506 -0.25227828005356 0.886237845881933 0.988301482344111 0.0380719955528865 "EGFR MUT" "DMOG_IC_50" 0.158170838203232 0.634384322036726 0.536977381970914 0.281261608690608 0.872690257628506 0.369663582869161 0.123008370927911 0.81222107227567 0.581131131702467 "AKT2 MUT" "PD.173074_IC_50" 0.218609049338369 0.692391928378764 0.7958719842829 0.281411975691742 0.872690257628506 0.595949663114637 0.203984287299252 0.853438950500765 0.762775879988203 "TET2 MUT" "JNK.Inhibitor.VIII_IC_50" 0.97918262673946 0.996276778834563 0.0172615267175583 0.281748977490237 0.872690257628506 0.686397662911293 0.154151436462956 0.835611501078903 1.16698406416398 "EZH2 MUT" "Gefitinib_IC_50" 0.305065740202113 0.754224310561809 -0.747922452290083 0.281753245214978 0.872690257628506 -0.702952130047889 0.208309153603987 0.853446327418758 -0.824288731054409 "EZH2 MUT" "JNK.Inhibitor.VIII_IC_50" 0.21949146230473 0.692453909775927 -0.629933333333329 0.281832554765642 0.872690257628506 -0.525234314686489 0.224698225771726 0.86643108387559 -0.625660077509334 "EP300 MUT" "CHIR.99021_IC_50" 0.318394074208539 0.761267128904167 0.82830488773746 0.281909416164672 0.872690257628506 0.848040020633881 0.134151694895603 0.827361946088783 1.19291803654411 "TET2 MUT" "ABT.263_IC_50" 0.367160882826084 0.788956157846227 -1.13560509915201 0.281992063704858 0.872690257628506 1.23672929394385 0.635659876666354 0.953101495776253 0.636929686006282 "KDM6A MUT" "EHT.1864_IC_50" 0.384968457405252 0.798746759187088 -0.30914280936455 0.282220717886573 0.872690257628506 -0.380437818193794 0.173335082285716 0.844239622796781 -0.472037468427742 "FLT3 MUT" "MK.2206_IC_50" 0.267446248455338 0.731277750163748 1.14595719421484 0.282252694869781 0.872690257628506 0.89804121536513 0.0604055305155266 0.702533085254831 1.89756362315625 "IDH1 MUT" "NSC.87877_IC_50" 0.260860482852105 0.724195669962347 -0.891066206896562 0.28225579767341 0.872690257628506 -0.833306591226216 0.312534743786286 0.898841016698837 -0.817234361150872 "NOTCH1 MUT" "PD.173074_IC_50" 0.167766930697179 0.647446641789 -0.537975122857139 0.28249476807458 0.872690257628506 0.375085169321471 0.591771277327116 0.949294892873838 0.209714094827134 "CDKN2C MUT" "Parthenolide_IC_50" 0.209312823894052 0.683860903264959 -0.824413549488056 0.282557963292761 0.872690257628506 -0.659423308991254 0.322112288200455 0.900918773778407 -0.812360929057926 "KIT MUT" "A.770041_IC_50" 0.649017027945748 0.898555566178892 -0.825622328813558 0.282614002751454 0.872690257628506 1.64978433686721 0.446857401250201 0.925809648901546 1.3214671375896 "FLCN MUT" "Temsirolimus_IC_50" 0.293369114566002 0.747036827777118 1.20212380761905 0.282656728205565 0.872690257628506 0.937884563901621 0.402570875457968 0.916850640727267 1.28154892360487 "CCND2 MUT" "PF.4708671_IC_50" 0.20173784789032 0.674012093366938 -1.06207769058295 0.282677081747743 0.872690257628506 -0.876023967760243 0.241120995630439 0.875707386589409 -0.990114995207817 "CDH1 MUT" "BMS.536924_IC_50" 0.463499666513485 0.829490249358073 0.816932828767118 0.282756994054365 0.872690257628506 0.895177859900506 0.230916933046315 0.868971729823866 1.29680910323135 "MLL_AFF1 MUT" "GSK269962A_IC_50" 0.545058159246314 0.862633715268747 0.992342508474585 0.283117321968635 0.872690257628506 1.6763087991016 0.495544857017819 0.933639405738697 1.11671010451493 "MS-HL MUT" "ATRA_IC_50" 0.688673982046136 0.911985814812204 -0.0928051916418107 0.283145341590738 0.872690257628506 0.196234639649181 0.325683562864988 0.900918773778407 0.218462982379416 "CTNNB1 MUT" "SL.0101.1_IC_50" 0.140142812963849 0.610401334934745 0.503736802413276 0.283233885492106 0.872690257628506 0.320147922168195 0.221888533873719 0.865076203633533 0.437911590925022 "HRAS MUT" "BAY.61.3606_IC_50" 0.830984434921726 0.958562510266249 0.183262314685313 0.283239854591979 0.872690257628506 -0.643611927607474 0.94876333929017 0.995668765770473 -0.0518515504966915 "BRCA2 MUT" "CCT018159_IC_50" 0.436586064570185 0.823808548892323 -0.49480988505746 0.28329084006554 0.872690257628506 -0.642419321107583 0.267241145474672 0.877052916121269 -0.719343345873758 "PIK3CA MUT" "AZD6244_IC_50" 0.0441404567023129 0.376006653842012 0.704132857164402 0.283555544321141 0.872690257628506 0.344448521907777 0.103212858652025 0.780450419545322 0.559898187289211 "GNAS MUT" "MG.132_IC_50" 0.75683557403082 0.934762260113025 0.368508962585035 0.283623890894331 0.872690257628506 1.12488698018954 0.694665331824596 0.961100601384891 0.446509211112841 "MSH6 MUT" "Cisplatin_IC_50" 0.359473013547695 0.786601117838604 -0.577936751231527 0.283703916054067 0.872690257628506 -0.586192041635951 0.324616051672499 0.900918773778407 -0.591856163677573 "PTEN MUT" "Bortezomib_IC_50" 0.122106152576566 0.580982694522287 -0.543285996447164 0.283745011975877 0.872690257628506 -0.311638135583355 0.678935895816293 0.961100601384891 -0.152438273983478 "GNAS MUT" "BIRB.0796_IC_50" 0.751265479186698 0.932940664991998 -0.137310115606935 0.283817878883196 0.872690257628506 -0.443754340442659 0.675743850747865 0.960256725054738 -0.178927957505034 "SMARCA4 MUT" "Gemcitabine_IC_50" 0.199074591795547 0.674012093366938 1.58328308833923 0.283838648917771 0.872690257628506 0.879078023732921 0.167845065773562 0.84067330207935 1.78928768144844 "SMAD4 MUT" "WO2009093972_IC_50" 0.030536558471318 0.324008573218369 0.672546876172608 0.283997614704151 0.872690257628506 0.309055914913086 0.214812968344448 0.859434499119166 0.404967314635457 "CDKN2a(p14) MUT" "S.Trityl.L.cysteine_IC_50" 0.0402361498035018 0.362411000410649 -0.529605860416668 0.284024244072316 0.872690257628506 -0.162981336215044 0.249864163587317 0.875707386589409 -0.344825949362502 "CDKN2a(p14) MUT" "Vinblastine_IC_50" 0.00869437468154235 0.16428668414208 -0.418123294637722 0.284037893145788 0.872690257628506 -0.128822441828178 0.153171885838272 0.835611501078903 -0.238975769509781 "SETD2 MUT" "PF.02341066_IC_50" 0.461972147547586 0.82931728663973 -0.848484761744955 0.28422724172725 0.872690257628506 -1.15226314049372 0.428292781274205 0.922428741067589 -0.905209074491325 "SETD2 MUT" "A.770041_IC_50" 0.234176313570176 0.707628390886945 -2.15590043050847 0.284382311233841 0.872690257628506 -1.5962338283716 0.999575817117588 0.999751228014461 -0.000925684611937899 "MLLT3 MUT" "BMS.708163_IC_50" 0.350653318839942 0.784966682190403 0.288249966589863 0.284439891518139 0.872690257628506 0.332706284440745 0.595203580228818 0.949294892873838 0.170068828295842 "TP53 MUT" "CCT018159_IC_50" 0.0359560098097592 0.347470427769827 -0.300161554646403 0.28450834103067 0.872690257628506 -0.151229734812049 0.0826214836984347 0.745860856369627 -0.271075896162068 "KRAS MUT" "BAY.61.3606_IC_50" 0.277165930872059 0.735258595314258 -0.247554482926827 0.284832341635224 0.872690257628506 -0.178758523949318 0.0183528772026582 0.513871228544795 -0.575808141162524 "PIK3CA MUT" "Bleomycin_IC_50" 0.184661476474402 0.66048271146563 -0.624906043481343 0.284960260033779 0.872690257628506 -0.414338467845161 0.0438217013880567 0.659657620288543 -1.00293206041246 "CDKN2A MUT" "GSK.650394_IC_50" 0.0314524064661801 0.328181974777787 -0.375937389400071 0.28509426772282 0.872690257628506 0.126862151736181 0.441979124948508 0.924472815010418 -0.153359468987475 "MLH1 MUT" "BX.795_IC_50" 0.306745014366115 0.755024525457845 0.497602782380508 0.285173894751658 0.872690257628506 0.40655018909722 0.0703650101689764 0.727487375216157 0.785623017651495 "RB1 MUT" "Parthenolide_IC_50" 0.628813091907529 0.89199610982384 -0.122433388213442 0.285281266769899 0.872690257628506 -0.256802755962916 0.493651308143984 0.933639405738697 -0.210464999332322 "NF1 MUT" "AZD7762_IC_50" 0.808250973216782 0.952641225877339 -0.094469511971196 0.285369772129873 0.872690257628506 -0.326825955035808 0.190688383853782 0.851001889249827 -0.492113269173721 "NF2 MUT" "GDC.0449_IC_50" 0.73652965151813 0.928872455997232 -0.0915791325508167 0.285386850972553 0.872690257628506 -0.260822771685911 0.433146888280126 0.922569292988365 -0.225896553622967 "PTEN MUT" "CCT007093_IC_50" 0.109321520372102 0.557261619917495 -0.221284394745595 0.285506011209358 0.872690257628506 -0.152846748553467 0.119977439786676 0.80757178183218 -0.237724463735942 "FGFR3 MUT" "X17.AAG_IC_50" 0.54149217359111 0.861627420578681 -0.949240466666686 0.285536080015664 0.872690257628506 -1.45926890254364 0.900576630913461 0.988704788932507 -0.170023334494158 "PIK3R1 MUT" "CMK_IC_50" 0.984132844888007 0.996723172778267 -0.0153209347079043 0.285606816425307 0.872690257628506 -0.74933063867978 0.956943158734793 0.99641548698706 -0.0422068623762582 "MYCN MUT" "PAC.1_IC_50" 0.240639137570719 0.711340033600749 -0.46067960385996 0.285649606586471 0.872690257628506 -0.35672242637344 0.155917068703897 0.837288218996252 -0.622948966562033 "MLLT3 MUT" "NVP.TAE684_IC_50" 0.400163428128959 0.806000156924025 0.663947565517242 0.285735224467873 0.872690257628506 0.684992658439297 0.303675141473829 0.894622967627816 0.8580784705349 "BCR_ABL MUT" "MS.275_IC_50" 0.0877426991874614 0.511142337432447 -1.88093294845361 0.2857365543051 0.872690257628506 -1.23848646552837 0.166583838727897 0.84067330207935 -1.61071184713397 "CDKN2A MUT" "Bortezomib_IC_50" 0.00073047027193263 0.036445542050751 -0.917106341746797 0.285754224657549 0.872690257628506 -0.253034341440215 0.645196662121195 0.956971941901975 -0.138849370848627 "FGFR2 MUT" "Paclitaxel_IC_50" 0.0745268369653273 0.480000945545953 2.68805127210885 0.285945973898128 0.872938508385498 -0.715960230426023 0.453208397459667 0.925809648901546 1.38062732713483 "EGFR MUT" "GW843682X_IC_50" 0.199753947444142 0.674012093366938 1.00454730348432 0.286032097669384 0.872938508385498 0.428232741307601 0.160786113342949 0.839927262232576 1.15038756311937 "BRCA1 MUT" "FTI.277_IC_50" 0.408554341743106 0.810304102803978 0.408907012131713 0.2861549737078 0.873013507900713 0.481097219632308 0.604704494603643 0.949657634568742 0.243811942953198 "KIT MUT" "PAC.1_IC_50" 0.307798133460225 0.756379419828515 0.790345793706298 0.286321336537125 0.873221081657353 0.692618536441991 0.587004341952326 0.949294892873838 0.40683323846783 "MYCN MUT" "WO2009093972_IC_50" 0.562728491422761 0.871238675201477 0.227226365476189 0.286531853815148 0.873308892980108 -0.398657258811916 0.603469968718499 0.949657634568742 -0.259252457540404 "EZH2 MUT" "NVP.BEZ235_IC_50" 0.314572032953991 0.760194346847454 -0.778662489021952 0.286546798124539 0.873308892980108 -0.591850616070369 0.144964540449439 0.831473272394224 -1.06857715301323 "EZH2 MUT" "CEP.701_IC_50" 0.560912238279185 0.870276331255523 0.482403529007637 0.286691514612536 0.873350723396422 0.645686749405078 0.618353138230336 0.950394619652337 0.373870445231962 "KRAS MUT" "IPA.3_IC_50" 0.448941817660066 0.827360921900611 0.186305413944319 0.286757201826818 0.873350723396422 0.232437883632181 0.350264361595653 0.910340341961272 -0.244287928321978 "TET2 MUT" "Bryostatin.1_IC_50" 0.96469392958189 0.994434372972651 -0.0323015197444826 0.286995977865703 0.873778292569525 -0.741349878732112 0.200211216612443 0.851001889249827 -1.09356979622493 "CDH1 MUT" "Cytarabine_IC_50" 0.0195335196714929 0.252811438707561 1.64629659333011 0.287129871625018 0.873886357060241 0.576877510307009 0.176010490832847 0.847235321998113 0.951041483137001 "KDM5C MUT" "Methotrexate_IC_50" 0.814016176468049 0.953913887475092 -0.369266112224445 0.287308949694207 0.873930317824813 1.27648402281551 0.985757316594579 0.998124818853736 -0.0220230297187336 "JAK2 MUT" "Pyrimethamine_IC_50" 0.519324325024738 0.852599738673405 -0.869070680272116 0.287359157552119 0.873930317824813 -1.20039344066082 0.725833850532422 0.965402608571648 0.58595710965672 "MYCL1 MUT" "GW843682X_IC_50" 0.695730708897251 0.913751024211252 -0.393316254295535 0.288118676156873 0.873930317824813 -0.557762264729997 0.266490945209586 0.877052916121269 -1.20598128123602 "CDKN2C MUT" "NVP.BEZ235_IC_50" 0.864275202901657 0.967489995749939 0.0940068521126769 0.288161767055732 0.873930317824813 0.422889250726542 0.255655865063339 0.875707386589409 0.635801542592206 "ERBB2 MUT" "Thapsigargin_IC_50" 0.0378791765374463 0.352922011796915 1.46808718298319 0.288162116307851 0.873930317824813 0.589760143426506 0.200306491200229 0.851001889249827 0.934191753502653 "MSH6 MUT" "PF.02341066_IC_50" 0.308156919151412 0.756423880316111 -0.833645976351359 0.288320134595842 0.873930317824813 -0.801778087798437 0.432361413412014 0.922569292988365 -0.626130224697262 "EGFR MUT" "X17.AAG_IC_50" 0.236247008991567 0.70906038758165 -0.565821248334832 0.28835745514293 0.873930317824813 -0.446238895445774 0.709295101750225 0.962630898212352 -0.164051296968379 "ALK MUT" "A.443654_IC_50" 0.849216475315922 0.963526482778845 -0.194095575342466 0.288359041116345 0.873930317824813 -0.703665882190602 0.495156037106459 0.933639405738697 -0.831132492841155 "IDH1 MUT" "Thapsigargin_IC_50" 0.233950995510723 0.707628390886945 -2.42461442434784 0.288361853447876 0.873930317824813 -1.64161744293084 0.630550492605151 0.952523560833852 -0.958293882044718 "IDH1 MUT" "Doxorubicin_IC_50" 0.16797102593911 0.647446641789 -1.90286979652175 0.288385014007494 0.873930317824813 -0.909637711745058 0.263698668948386 0.877052916121269 -1.47760579372678 "FAM123B MUT" "VX.702_IC_50" 0.276873158776487 0.735108059249974 0.817401704980844 0.288682752877568 0.873930317824813 0.652953029359642 0.446448386673198 0.925809648901546 0.540580211154092 "BRCA1 MUT" "Imatinib_IC_50" 0.332741312411068 0.773185226006147 0.955072760942754 0.288794282085165 0.873930317824813 1.0302863968119 0.30110571088878 0.894167310052 1.09128101996422 "MSH2 MUT" "SL.0101.1_IC_50" 0.853872162263511 0.964541653680809 -0.0852918881506079 0.288846469031336 0.873930317824813 0.427711914629307 0.595523035760884 0.949294892873838 0.237998878044316 "CDKN2C MUT" "X17.AAG_IC_50" 0.204438702217684 0.676208608713317 -0.991569067919069 0.288953360989932 0.873930317824813 -0.730606024877813 0.514111763864606 0.939635632721979 -0.479505627807874 "MYCL1 MUT" "Bosutinib_IC_50" 0.208240625787619 0.681549356120119 0.805164638246626 0.28902795210442 0.873930317824813 0.555431640695131 0.429279316978493 0.922428741067589 0.512986802020225 "KDM5C MUT" "AZD6482_IC_50" 0.151492694656768 0.625830613280407 1.41376600865054 0.289041089526544 0.873930317824813 0.883115050314039 0.164648473267521 0.8403695925798 1.33318748616797 "SMARCA4 MUT" "Cyclopamine_IC_50" 0.126883572169571 0.587206821914858 1.30701649484535 0.289097976905832 0.873930317824813 0.835254283973218 0.437378636132631 0.922569292988365 1.14635408086146 "KDM6A MUT" "Sunitinib_IC_50" 0.0482726570397335 0.39044578066473 -1.19282195714285 0.289181223125738 0.873930317824813 -0.475735428461187 0.0273994856042882 0.588860092297546 -1.26618526136581 "EWS_FLI1 MUT" "BAY.61.3606_IC_50" 0.0138354783279456 0.212607581866345 -1.22781713665482 0.28925819649086 0.873930317824813 0.403965874183652 0.842143678832102 0.982408776002613 -0.106828072288564 "AKT2 MUT" "OSI.906_IC_50" 0.726911853034536 0.92560056809276 0.270686225062657 0.289301904612647 0.873930317824813 0.774848009541237 0.874921573301068 0.98777404048288 0.124040269973203 "KDR MUT" "Shikonin_IC_50" 0.95549844242922 0.992745778961198 0.066077070811741 0.289306826473992 0.873930317824813 1.05565869615106 0.636315232794138 0.953101495776253 0.551774528014689 "STK11 MUT" "CHIR.99021_IC_50" 0.440468371627399 0.824500931653809 0.23067254480287 0.28939778324069 0.873930317824813 0.300881240302586 0.348078076769656 0.909999728614578 0.288172379349916 "CCND1 MUT" "Bryostatin.1_IC_50" 0.446548140693868 0.825892730562573 0.189105766127945 0.289505098491388 0.873930317824813 0.250031653884521 0.153440727594277 0.835611501078903 0.363093839984916 "BRCA2 MUT" "SB590885_IC_50" 0.123726208579437 0.583699714338599 1.40483391260165 0.289506023537957 0.873930317824813 0.811726690759343 0.105217165424321 0.788057589876989 1.2985882876882 "SOCS1 MUT" "Elesclomol_IC_50" 0.474487916971361 0.834460661638643 1.10338834724857 0.289672631086843 0.873967034749009 1.35769139814284 0.647409805591924 0.957449344088104 0.665816515465304 "TSC1 MUT" "Vinorelbine_IC_50" 0.693947324898608 0.913368820021033 -0.564347094827593 0.289715003974899 0.873967034749009 -1.11497475667819 0.823192434032814 0.978066657907595 -0.314069384011214 "MLLT3 MUT" "AZD8055_IC_50" 0.621418016540248 0.888247588669681 0.172934365186073 0.289844464743773 0.87406067619336 0.287776958307156 0.565371863393086 0.949294892873838 0.205446939999869 "TP53 MUT" "Paclitaxel_IC_50" 0.192858517813808 0.668215486666746 -0.410181542279954 0.289976050149388 0.874160658987342 -0.149383934135689 0.262651909425156 0.877052916121269 -0.388141293876283 "IDH1 MUT" "Nilotinib_IC_50" 0.333289367940364 0.773234816269168 -1.12254401707779 0.290258102927788 0.874630310933377 -0.989740161043457 0.303815083650568 0.894622967627816 -1.07980777096958 "KIT MUT" "Erlotinib_IC_50" 0.917151418529364 0.984975746996111 0.126947018181819 0.290718080850815 0.874630310933377 1.20448782605807 0.624931081801915 0.950833122748468 0.587443076002039 "KDM6A MUT" "DMOG_IC_50" 0.201733806082105 0.674012093366938 -0.507531092436977 0.290792878665156 0.874630310933377 -0.379597482369159 0.462255581526271 0.929276781658587 -0.292122193966727 "CDKN2C MUT" "PF.562271_IC_50" 0.800805305570259 0.9507092914502 -0.123516204545455 0.290953624063893 0.874630310933377 -0.422941906481659 0.443618210505766 0.925809648901546 -0.439267555884666 "MET MUT" "SL.0101.1_IC_50" 0.785225523140264 0.946055035513406 -0.0968547455968696 0.290985362449128 0.874630310933377 -0.327700108926275 0.35431232881737 0.91150394419969 -0.315901793533409 "BRCA1 MUT" "PF.4708671_IC_50" 0.340315098481385 0.778500909061878 0.562435472972978 0.290987664564497 0.874630310933377 0.61601246599155 0.298781871100944 0.894167310052 0.619325083623536 "KIT MUT" "Shikonin_IC_50" 0.865698945763588 0.967741687593997 0.155388284922007 0.291046864776743 0.874630310933377 0.818089869520018 0.617270607929636 0.950247055931602 0.448680241332623 "CDK4 MUT" "ABT.263_IC_50" 0.944612497044112 0.990147156460271 -0.0482684623015886 0.291093713916383 0.874630310933377 -0.661726906823611 0.497785118626678 0.934042323734638 -0.428314227653166 "HRAS MUT" "AS601245_IC_50" 0.479577706151549 0.836304203722611 -0.571900821678316 0.291099311968173 0.874630310933377 -0.685647549553295 0.853468254704066 0.984631915507353 -0.147843509227892 "NF2 MUT" "BIRB.0796_IC_50" 0.390535087803864 0.801837403580487 -0.227319891989197 0.291128518920965 0.874630310933377 -0.271099183587524 0.33104848750899 0.902810042912437 -0.271804923947194 "KDM6A MUT" "AICAR_IC_50" 0.0336262699373095 0.337822288815889 -0.952590873015881 0.291268648973248 0.874630310933377 -0.426462666871374 0.0407404762849732 0.655464075881969 -0.912976847367552 "FGFR3 MUT" "Pyrimethamine_IC_50" 0.171513105858942 0.649721929411943 -2.25197030508475 0.291313642578643 0.874630310933377 -1.46537815377464 0.172282712119832 0.842832361237713 -2.25980123437028 "MYC MUT" "BMS.708163_IC_50" 0.410055280780777 0.812154538049528 0.183335117822967 0.291563499003489 0.875084634893542 0.23733961257127 0.360550661770207 0.91161229252998 0.217297851926591 "MYC MUT" "Lapatinib_IC_50" 0.982219751460668 0.996723172778267 0.00830312059925098 0.291693781555593 0.875179889863249 -0.347278349651303 0.775425627142873 0.972265282317641 -0.0985598582550875 "HRAS MUT" "GDC0941_IC_50" 0.77062364135597 0.939898671414565 -0.238031150826447 0.292096674097131 0.876092726327802 0.695183278414534 0.965416203816646 0.997126446878798 -0.0350725449578095 "GNAS MUT" "Thapsigargin_IC_50" 0.10730210005844 0.551794991672845 1.47668016225749 0.292571290549432 0.876993540227479 0.736424859799385 0.272286586542964 0.88125990345775 0.986238890649305 "FBXW7 MUT" "Lenalidomide_IC_50" 0.730667497776299 0.927803552723951 -0.0779040513833989 0.292701543180539 0.876993540227479 0.209582510070027 0.426722947627149 0.922428741067589 0.182629382575416 "KDM6A MUT" "WZ.1.84_IC_50" 0.01949777311201 0.252787916799651 -1.00136678571428 0.29289315268494 0.876993540227479 -0.37807331623827 0.0346519597298175 0.619203328693177 -0.937124651811748 "APC MUT" "Lapatinib_IC_50" 0.153471748924114 0.627813266787222 -0.780114322225812 0.292920339965543 0.876993540227479 -0.511791802219917 0.972110253763901 0.99742775226181 -0.020402652621678 "CDKN2C MUT" "BI.2536_IC_50" 0.898752081939579 0.978795346528664 0.119022309278351 0.292982916238361 0.876993540227479 0.585840571567443 0.659296948668897 0.958313128388245 0.519178728049818 "KDM6A MUT" "ABT.263_IC_50" 0.945095113202801 0.990147156460271 0.035949661514336 0.293113051980683 0.876993540227479 0.499020338549645 0.658812538445291 0.958313128388245 -0.206305886613358 "JAK2 MUT" "AMG.706_IC_50" 0.5791878772932 0.874194311383525 -0.291999717847764 0.293201924526445 0.876993540227479 -0.509035781316215 0.590555914416399 0.949294892873838 -0.288169223412876 "KDR MUT" "Bexarotene_IC_50" 0.748882103671938 0.932323030730707 0.297618906504062 0.293244332687125 0.876993540227479 0.870312096393269 0.175886089512259 0.847235321998113 1.21354334906795 "CDKN2C MUT" "TW.37_IC_50" 0.265962094226182 0.72856550241293 -0.616531497737554 0.293285757738499 0.876993540227479 -0.532632078604163 0.391834909521463 0.915926348152589 -0.50154125933294 "CTNNB1 MUT" "LFM.A13_IC_50" 0.620300551197549 0.887671478437871 0.143335444839859 0.293615078872533 0.877682771951183 0.286166627152932 0.495191010208721 0.933639405738697 0.220686836675606 "CDK6 MUT" "Epothilone.B_IC_50" 0.769650435577069 0.939297171686127 0.243350609841829 0.293735532841082 0.877747398102844 -0.497080920890416 0.849544768232731 0.984337428855677 0.164465173093925 "MYC MUT" "AUY922_IC_50" 0.211347540041463 0.685278387407167 0.374915168931279 0.29405188661085 0.878397176249903 0.21281020068913 0.879508554930645 0.988301482344111 -0.0459657284671249 "CTNNB1 MUT" "Bosutinib_IC_50" 0.446596473724634 0.825892730562573 0.384048101316976 0.294260789430881 0.878714297802737 0.435967390070756 0.981706464290904 0.997977517143419 -0.011697647094342 "SMARCA4 MUT" "Imatinib_IC_50" 0.242280155107601 0.711537717430754 0.94264226351352 0.294810709117814 0.878714297802737 0.834548455321817 0.58993438390273 0.949294892873838 0.788484657811246 "PIK3R1 MUT" "Salubrinal_IC_50" 0.0355593731283177 0.347105523744792 1.62458 0.295125197840834 0.878714297802737 0.665999239450297 0.0265409921247214 0.585472903331568 1.68582190120249 "CCND1 MUT" "SL.0101.1_IC_50" 0.583377716917744 0.876506729771444 -0.136785983935743 0.295205684692178 0.878714297802737 -0.22932176575948 0.155404004377384 0.837288218996252 -0.367874137255697 "CDH1 MUT" "BX.795_IC_50" 0.059748896015153 0.441088899011283 1.23313709659866 0.2952430500587 0.878714297802737 0.531903073460215 0.202920439700686 0.852959543285214 0.807284898408212 "KDR MUT" "Methotrexate_IC_50" 0.746731816018403 0.931110103613801 -0.414314588353417 0.295348983402274 0.878714297802737 -1.02104180291628 0.159328086037132 0.838901067822678 -1.44493235101027 "CDKN2C MUT" "JNK.Inhibitor.VIII_IC_50" 0.683966911143426 0.910554660150617 -0.165676753371868 0.295376068778756 0.878714297802737 -0.408335325623862 0.452820560851139 0.925809648901546 -0.329489954137442 "MYCL1 MUT" "Rapamycin_IC_50" 0.201795810735354 0.674012093366938 1.58587023469388 0.295490448094531 0.878714297802737 1.12472669734645 0.763862370661088 0.969901216545994 0.394310957039335 "MAP2K4 MUT" "NU.7441_IC_50" 0.111973305321304 0.563419220713034 0.663494699530513 0.295650709294978 0.878714297802737 0.383239839179787 0.423482442897974 0.922428741067589 0.356584091277324 "TP53 MUT" "AS601245_IC_50" 0.513267681032048 0.85130999259055 -0.103628017264061 0.295821659146025 0.878714297802737 -0.137485882592182 0.515770470224775 0.939635632721979 -0.109930690058574 "MS-HL MUT" "Vorinostat_IC_50" 0.129723953204318 0.591994759352302 -0.265227409222444 0.295875770995102 0.878714297802737 -0.139627517438847 0.886907910306776 0.988301482344111 0.0248696306148278 "MDM2 MUT" "AP.24534_IC_50" 0.882779398987364 0.973927829424842 -0.130181300699301 0.296078004825532 0.878714297802737 -0.830940815351882 0.92319040657702 0.993931766508607 -0.079783609044901 "BRCA1 MUT" "AKT.inhibitor.VIII_IC_50" 0.434991392895963 0.823150425912549 -0.561358008665507 0.296111782012798 0.878714297802737 -0.644785273289129 0.538725911211619 0.944569766818715 -0.433058221755233 "SMARCA4 MUT" "ZM.447439_IC_50" 0.172721877623671 0.650961807890931 0.69530176388889 0.296238726326717 0.878714297802737 0.421292636694917 0.863885743036339 0.987070266238225 0.0943464554940896 "SETD2 MUT" "BX.795_IC_50" 0.452523910384757 0.828509891052426 -0.850075943319823 0.29628752728894 0.878714297802737 -0.916328154611581 0.527074953034631 0.942410440487329 -0.630771317171399 "MLL_AFF1 MUT" "AZD6244_IC_50" 0.693734532196032 0.913368820021033 0.625079039175242 0.296288766087838 0.878714297802737 1.5316446469292 0.265597970022262 0.877052916121269 1.59775946703546 "MSH2 MUT" "GDC.0449_IC_50" 0.987724066038849 0.997949650795337 0.00772023994811901 0.296349346412072 0.878714297802737 0.466785140617366 0.84700669783683 0.98378870157398 0.096196780796169 "PIK3CA MUT" "PD.173074_IC_50" 0.73582586585505 0.928872455997232 0.0729959385560681 0.296379790031782 0.878714297802737 -0.196251943482522 0.647930476069081 0.957449344088104 0.100280593134122 "PIK3R1 MUT" "PF.4708671_IC_50" 0.314261580814858 0.760194346847454 0.450190816326535 0.296453869585694 0.878714297802737 0.460482056410025 0.246967925783997 0.875707386589409 0.52602518675782 "MLLT3 MUT" "X17.AAG_IC_50" 0.180106574423349 0.658614416960816 -0.705013125191006 0.296455408858334 0.878714297802737 -0.482261990217424 0.237064724860433 0.87287388950477 -0.574169560649717 "CDK6 MUT" "SL.0101.1_IC_50" 0.494936892675299 0.843282996121548 -0.279212256809338 0.296467388562686 0.878714297802737 -0.371946217255707 0.334060209058495 0.903569160603576 -0.379157755268905 "PIK3R1 MUT" "Bicalutamide_IC_50" 0.223685590484084 0.696139064632428 0.268564683655537 0.296692876626185 0.878714297802737 0.219144996472322 0.198010752810137 0.851001889249827 0.265099869480728 "ALK MUT" "BMS.754807_IC_50" 0.444178502623321 0.825606373270691 -1.24742140347827 0.296717103316934 0.878714297802737 -1.41855639342834 0.324327961649015 0.900918773778407 -2.21970054138899 "FAM123B MUT" "AG.014699_IC_50" 0.0230806150031906 0.277373398976097 1.63625191666668 0.296721790735141 0.878714297802737 0.66336854271055 0.0930156200649356 0.768046723169691 1.13858958391697 "EZH2 MUT" "Imatinib_IC_50" 0.260439345216662 0.723705201773835 0.78706359322034 0.296751135693029 0.878714297802737 0.721690344419553 0.206880724568947 0.853446327418758 1.06877275625106 "EZH2 MUT" "LFM.A13_IC_50" 0.233554277458429 0.707433676026027 0.500709398496248 0.296840365574906 0.878714297802737 0.412746135283255 0.436939790688687 0.922569292988365 0.350398035709181 "GNAS MUT" "WO2009093972_IC_50" 0.443787288091877 0.825606373270691 0.421126754672896 0.296915471535744 0.878714297802737 0.514682919358229 0.913062150346563 0.99082410867764 0.0596833338971922 "CDKN2a(p14) MUT" "PF.4708671_IC_50" 0.217189289722714 0.689960327486037 0.139742926418973 0.297027625836079 0.878714297802737 0.120319326092099 0.451159719941092 0.925809648901546 0.0963524127290634 "PTEN MUT" "JNK.Inhibitor.VIII_IC_50" 0.344332313301204 0.780249349533262 -0.135408571684267 0.297118266560607 0.878714297802737 -0.145695172066291 0.708856632339642 0.962630898212352 -0.0587470515624615 "AKT2 MUT" "PD.0332991_IC_50" 0.857341038477648 0.965514299102206 0.159270039419085 0.297179751375176 0.878714297802737 -0.737211955967785 0.730860198248556 0.96639568318693 -0.288015670414372 "SMARCA4 MUT" "Axitinib_IC_50" 0.643613504256208 0.896335507495591 -0.262652091907515 0.297225284382324 0.878714297802737 -0.496808925620592 0.401891675250461 0.916589616820582 0.476673308643777 "KDM5C MUT" "Bleomycin_IC_50" 0.227904716390728 0.700111306214477 -1.99415536212917 0.297537680234362 0.878991031054172 -1.40525967600247 0.206324494151466 0.853446327418758 -2.0065075678577 "CCND1 MUT" "Shikonin_IC_50" 0.963190683653076 0.994159243759316 -0.0186051779779796 0.297559513285628 0.878991031054172 -0.356089308121628 0.81707006504315 0.977383317127464 -0.0975596672965513 "FLT3 MUT" "BIRB.0796_IC_50" 0.521941325321887 0.853303159804623 0.450756933842254 0.297615812451289 0.878991031054172 0.706976398651235 0.305027571180732 0.896105449118166 0.717159920992188 "MLL_AFF1 MUT" "Thapsigargin_IC_50" 0.524230093713512 0.854725328793752 -1.29785885913045 0.297764792787402 0.879138671790199 1.64654579810828 0.643514639163733 0.955972780483685 -0.922505566345533 "MET MUT" "DMOG_IC_50" 0.546265527551428 0.86289571535809 0.328694761980574 0.298098190972685 0.879316070343899 0.511457340492412 0.900696815012059 0.988704788932507 -0.0640649035407642 "KDM6A MUT" "PHA.665752_IC_50" 0.141814880079144 0.614369731698966 -0.516344348591548 0.298340398529863 0.879316070343899 -0.364949379878982 0.0763427584470615 0.741811190933953 -0.693334253611 "FLT3 MUT" "MG.132_IC_50" 0.389156894864565 0.800765149048239 -1.18076856497175 0.298344269767999 0.879316070343899 -1.27521379102558 0.168445967169757 0.84067330207935 -1.76557318175167 "MLLT3 MUT" "LFM.A13_IC_50" 0.163936348758197 0.639629578008075 -0.341938540596098 0.298356187890998 0.879316070343899 -0.2393644765064 0.237996605560731 0.874854244199028 -0.301539699483443 "CTNNB1 MUT" "Lenalidomide_IC_50" 0.141525194837519 0.613849754216838 0.437804524448415 0.298404253368279 0.879316070343899 0.272378635321133 0.21206961256392 0.855697514393537 0.389175235239768 "SMAD4 MUT" "GW.441756_IC_50" 0.921074181728601 0.986093099936007 -0.0238097633908807 0.298418943364093 0.879316070343899 -0.251029369600147 0.710009526450004 0.962630898212352 0.0941067042414364 "MYC MUT" "Embelin_IC_50" 0.15196048661631 0.625830613280407 0.324840914118981 0.29874546280678 0.879986220625874 0.189399780678985 0.42489872946221 0.922428741067589 0.189334097195512 "PDGFRA MUT" "LFM.A13_IC_50" 0.555789950353746 0.867599054990591 0.292604790209791 0.298934858358149 0.879988105018899 0.483983593273287 0.263088745882188 0.877052916121269 0.562267485616139 "TET2 MUT" "SB.216763_IC_50" 0.858223734183232 0.965651207814682 0.150528600260417 0.298999751358759 0.879988105018899 0.856555420806743 0.682850555699168 0.961100601384891 0.409313412049486 "STK11 MUT" "A.770041_IC_50" 0.283757307978066 0.739564104351618 -1.23512594863013 0.299053666855144 0.879988105018899 -0.975848674861158 0.970273920604591 0.997173634484198 -0.0465246924118135 "NF1 MUT" "GSK269962A_IC_50" 0.589523180494131 0.876506729771444 -0.341417246340231 0.299247268365553 0.879988105018899 -0.617103306189113 0.660727117119336 0.958689538788368 0.313296171050871 "KDR MUT" "KU.55933_IC_50" 0.288962335837223 0.744702123824371 0.770287483530969 0.299440146806857 0.879988105018899 0.670905015322457 0.29835470693345 0.894167310052 0.752470346938369 "MDM2 MUT" "BAY.61.3606_IC_50" 0.377003447673555 0.795261485512158 0.538547837742504 0.299479967925128 0.879988105018899 -0.439990092008363 0.675821693004669 0.960256725054738 0.238661084559093 "CDK4 MUT" "Sunitinib_IC_50" 0.460098376087183 0.828966839128293 -1.23499905782313 0.299495838758287 0.879988105018899 -1.2887302428027 0.427815825511746 0.922428741067589 -1.16528000773287 "CDK6 MUT" "ABT.263_IC_50" 0.731706624450707 0.928176068595523 -0.250829679867988 0.299538795346485 0.879988105018899 -0.681986465360211 0.133122965108521 0.826023079873761 -0.950945482731072 "PIK3CA MUT" "AZD.0530_IC_50" 0.669753541755365 0.906882709825482 0.244511751748253 0.299882679657215 0.880707036387475 0.514577576575609 0.675817853252844 0.960256725054738 0.247519422721848 "MET MUT" "LFM.A13_IC_50" 0.545668021569944 0.862751949361345 0.203418117571476 0.300189456562695 0.881316549994479 0.329300349291301 0.46769726238857 0.929276781658587 0.243897796663285 "BRCA1 MUT" "GSK269962A_IC_50" 0.403483323510524 0.807711061141052 1.36948216949152 0.30029537725343 0.88132361519926 1.58389799762597 0.449648365313452 0.925809648901546 1.24950572794024 "FLT3 MUT" "SB590885_IC_50" 0.450483519840413 0.828077050034054 -0.795138029073676 0.300466332431481 0.88132361519926 -0.92365435978302 0.893100051904241 0.988301482344111 -0.124423305955379 "TP53 MUT" "GDC.0449_IC_50" 0.419106350656123 0.81418600684961 -0.0917283134011032 0.30053730404943 0.88132361519926 -0.109028411934541 0.349174851381592 0.909999728614578 -0.11262306526872 "ALK MUT" "XMD8.85_IC_50" 0.383050513777527 0.798569876743396 0.921047869415802 0.300614427798482 0.88132361519926 0.942678448959955 0.625089448361675 0.950863149839883 0.622932975084307 "ERBB2 MUT" "GSK.650394_IC_50" 0.571555231119 0.872389778906173 0.289833826260505 0.300823665768339 0.88132361519926 -0.351119867123641 0.851495261804074 0.984550422117456 0.101263965484396 "MSH2 MUT" "PD.0325901_IC_50" 0.25589671560877 0.720311238267775 0.970891089428581 0.300848265698792 0.88132361519926 0.830325278154314 0.612931809609925 0.949930222127033 0.381506140203649 "NRAS MUT" "KIN001.135_IC_50" 0.117163641231949 0.572601844763368 0.269160239579913 0.300922820776282 0.88132361519926 0.181182225859729 0.403891754591898 0.917324899625757 0.151620696710769 "STK11 MUT" "VX.680_IC_50" 0.383241574468618 0.798569876743396 1.03333645704468 0.300985758912212 0.88132361519926 0.798723325054079 0.565264014578026 0.949294892873838 0.802142782352254 "FGFR3 MUT" "PF.4708671_IC_50" 0.540635455118736 0.861616652986104 0.509387780269047 0.301251967294977 0.881628328797914 0.849999659098366 0.476368733673655 0.929855889225741 0.599891295426548 "JAK2 MUT" "OSI.906_IC_50" 0.152711794982638 0.626146561053006 1.10745191428573 0.301290698098224 0.881628328797914 0.756747813526372 0.168636480692292 0.84067330207935 1.16455159498279 "CCND1 MUT" "A.443654_IC_50" 0.572364299914229 0.872389778906173 -0.337348624413145 0.301584231164887 0.881628328797914 -0.409304693059125 0.997271098125096 0.999545005862799 0.00242674053724637 "CDK4 MUT" "A.443654_IC_50" 0.72086734761524 0.922822998769296 0.514071544217688 0.301588007447498 0.881628328797914 0.972692673899 0.537111942765335 0.943443271455699 0.911730891653394 "MSH6 MUT" "AS601245_IC_50" 0.278819705850246 0.736963633230962 -0.694201232425311 0.301634210089759 0.881628328797914 -0.52954974308394 0.255368375002366 0.875707386589409 -0.716216546817493 "ERBB2 MUT" "Shikonin_IC_50" 0.892530318867722 0.975972789421281 0.0680305755335746 0.301852012608865 0.881628328797914 -0.449880428924906 0.541510936943584 0.945765861891114 -0.318040263688056 "TP53 MUT" "BMS.509744_IC_50" 0.23245261576935 0.705058634100954 0.250221751457078 0.301868913729749 0.881628328797914 0.172954390801118 0.456193453346777 0.925809648901546 0.169012341576102 "BRCA1 MUT" "KIN001.135_IC_50" 0.47845633694543 0.836304203722611 0.39065067340067 0.30196273650341 0.881628328797914 0.555285685420692 0.361857176661181 0.91161229252998 0.477286567870791 "MDM2 MUT" "AZ628_IC_50" 0.887967048475374 0.975214727041194 -0.171450463917526 0.302060367373323 0.881628328797914 0.934656218785741 0.711141907859552 0.962630898212352 -0.389736477507421 "MS-HL MUT" "GSK269962A_IC_50" 0.318750087392353 0.761267128904167 0.400070634931924 0.302181638437657 0.881628328797914 0.392700405248613 0.275724780480179 0.883780956691668 0.487302128377584 "EWS_FLI1 MUT" "BIRB.0796_IC_50" 0.036956076218581 0.351023436253709 -0.685764800891124 0.302181807551047 0.881628328797914 -0.34329852096707 0.166826780612965 0.84067330207935 -0.521842424062017 "EZH2 MUT" "VX.680_IC_50" 0.33388365237125 0.773264085106582 1.27797640068493 0.302583150907564 0.882043148335538 -0.884639944249151 0.0484297560743415 0.676839988046433 3.08174725604679 "JAK2 MUT" "NSC.87877_IC_50" 0.16422520437379 0.640241760623025 0.591633167701878 0.302602851928922 0.882043148335538 0.43116813056356 0.167174948832291 0.84067330207935 0.648396015270917 "KRAS MUT" "Z.LLNle.CHO_IC_50" 0.14219681957279 0.614525525365426 -0.577474852842806 0.302686635733967 0.882043148335538 -0.398004562049578 0.28502881511825 0.8879937007725 -0.449312864165532 "APC MUT" "BI.2536_IC_50" 0.926352414285917 0.98643792569589 0.0644160209790225 0.302786418925783 0.882043148335538 0.437824655731163 0.304307579902125 0.895478998379977 0.878574121410674 "MYCL1 MUT" "PD.0332991_IC_50" 0.114907260392354 0.567167686753817 1.18148573601191 0.302833584276222 0.882043148335538 0.615317769780686 0.215950663775771 0.860576337437605 0.954950149291739 "MLLT3 MUT" "AZD6482_IC_50" 0.223359869344773 0.696139064632428 -0.520067694318178 0.302919896680936 0.882043148335538 -0.369621036106337 0.558274854970989 0.94928677421639 -0.254648915917462 "MET MUT" "Metformin_IC_50" 0.130773777290235 0.59349449267004 0.634764534883715 0.303461359858667 0.88224197110117 0.404215683636775 0.250672826572646 0.875707386589409 0.472845477785037 "PTEN MUT" "XMD8.85_IC_50" 0.295661614446395 0.747204646998838 -0.29769048979592 0.303467396599346 0.88224197110117 -0.25681386326116 0.757729790217118 0.969901216545994 -0.0947390569852195 "BCR_ABL MUT" "Docetaxel_IC_50" 0.600130074031594 0.880698848449586 0.475518310077525 0.303638982113905 0.88224197110117 -0.853298513613533 0.922638620110538 0.993931766508607 0.0874396561973103 "BRAF MUT" "GW.441756_IC_50" 0.446674922965696 0.825892730562573 -0.131819408323745 0.303680037629304 0.88224197110117 -0.192328053595938 0.190147536781298 0.851001889249827 -0.268339358596047 "IDH1 MUT" "Temsirolimus_IC_50" 0.25137313082345 0.717470497840808 -1.85209321821631 0.303736546526607 0.88224197110117 -1.26192995585926 0.264730396220949 0.877052916121269 -1.72011956185443 "MLLT3 MUT" "BI.D1870_IC_50" 0.488030247937464 0.841371294978366 0.267587812922942 0.303860702289418 0.88224197110117 0.341609123052198 0.472044571694522 0.929276781658587 0.276757590798 "NF2 MUT" "JNK.Inhibitor.VIII_IC_50" 0.645631884235405 0.897070476954727 -0.114412990099009 0.303881760559277 0.88224197110117 -0.247477835074177 0.944211813332447 0.995333788087439 -0.0187336122713774 "PIK3CA MUT" "Salubrinal_IC_50" 0.265029024111722 0.726697783882931 0.543250763775232 0.303891173728536 0.88224197110117 0.413455143945915 0.291642902368324 0.891287204381652 0.559981874487895 "FBXW7 MUT" "Dasatinib_IC_50" 0.610082169202184 0.884449844055598 0.674831556329845 0.304055758746176 0.88224197110117 1.13411017656883 0.860893791300127 0.985524480087535 0.207320578540686 "FGFR2 MUT" "PF.4708671_IC_50" 0.228557001122483 0.700676460618178 1.00183621076231 0.304071963529509 0.88224197110117 0.854985060765214 0.42759917963076 0.922428741067589 0.945398665383064 "RUNX1 MUT" "Gefitinib_IC_50" 0.291081701642247 0.746581806188469 0.991999799112795 0.304354834429783 0.88224197110117 0.865330661994977 0.20603398717986 0.853446327418758 1.06174055851769 "CDK4 MUT" "Mitomycin.C_IC_50" 0.258630784249328 0.723189643810247 0.890742154876984 0.304453859668632 0.88224197110117 0.635880736475392 0.258337956223698 0.877052916121269 0.919627977060207 "FBXW7 MUT" "Bleomycin_IC_50" 0.240636835812544 0.711340033600749 -0.840817932022923 0.304512181144105 0.88224197110117 -0.605308923209658 0.939492812593846 0.994831655017307 -0.0545517064736381 "MYCN MUT" "AUY922_IC_50" 0.173519026853124 0.65113493295882 0.586042123877912 0.304601809426783 0.88224197110117 0.301990213314778 0.428423921064167 0.922428741067589 -0.378177935701601 "SMARCA4 MUT" "Shikonin_IC_50" 0.235176126118034 0.708239801985169 0.774153744755244 0.30471315943512 0.88224197110117 0.561392226352288 0.13858445460567 0.831473272394224 1.07688508192312 "MS-HL MUT" "Midostaurin_IC_50" 0.504337911389484 0.847595766822021 -0.158950343359376 0.304897521665596 0.88224197110117 0.189271196926518 0.100963648808972 0.774133667469059 -0.394463026200555 "FGFR3 MUT" "AZD.0530_IC_50" 0.758777773353125 0.934762260113025 -0.440502622895615 0.305196460232175 0.88224197110117 1.2643407232782 0.997113147649716 0.999545005862799 0.00490080930496596 "CDKN2C MUT" "AZD.0530_IC_50" 0.572301091924357 0.872389778906173 0.470740174061434 0.3052982734279 0.88224197110117 0.738382442554171 0.470332319924328 0.929276781658587 0.688193578084179 "MET MUT" "GW.441756_IC_50" 0.206605610827741 0.67932781553542 0.448254376531272 0.305328189835923 0.88224197110117 0.356951413157005 0.175230899542185 0.846738869764556 0.47653257096564 "MSH2 MUT" "Lapatinib_IC_50" 0.451237434134468 0.828325682626749 0.605053135888504 0.305514601534357 0.88224197110117 0.71262963183901 0.976555235570173 0.99742775226181 0.0210133202977581 "MSH2 MUT" "PD.173074_IC_50" 0.958261374451343 0.993340772343095 -0.0286921386306004 0.305551937229331 0.88224197110117 0.47821029190798 0.437697496716114 0.922569292988365 0.394230874081825 "MLH1 MUT" "X681640_IC_50" 0.120797515594042 0.580044291137328 -0.770597061983458 0.305617683252322 0.88224197110117 -0.440549162509165 0.352026687457722 0.91110953125066 -0.438749614811603 "RUNX1 MUT" "RO.3306_IC_50" 0.239891461087638 0.711340033600749 -0.999584266144818 0.305665412734355 0.88224197110117 -0.827682023697672 0.275136603657232 0.883780956691668 -0.919687762908756 "FAM123B MUT" "AZD6244_IC_50" 0.388844377097034 0.800307511703073 -1.3674136824742 0.305814067598721 0.88224197110117 -1.47284899691992 0.195009116965857 0.851001889249827 -1.83280195163486 "EZH2 MUT" "Docetaxel_IC_50" 0.791389127186137 0.94790644179192 -0.239960372093025 0.305849991581374 0.88224197110117 -0.693957559097934 0.553366873769339 0.947645397616448 -0.516737932853693 "JAK2 MUT" "BX.795_IC_50" 0.0983606702575925 0.536152212572481 1.08307010340138 0.305878866756294 0.88224197110117 0.517668809963508 0.956674308644594 0.996361528879345 0.0346828131057197 "MYCL1 MUT" "CGP.60474_IC_50" 0.259487815692675 0.723189643810247 0.864127673563225 0.30597676499075 0.88224197110117 0.59203782816518 0.839484460652564 0.98178039101519 -0.157747975050624 "PIK3R1 MUT" "NSC.87877_IC_50" 0.458399140440027 0.828966839128293 -0.315563850931681 0.306054971748469 0.88224197110117 -0.427796648253376 0.433987851891109 0.922569292988365 -0.33661029189265 "FLCN MUT" "Vinorelbine_IC_50" 0.469209164961181 0.83190905508009 0.658085901213166 0.306070524916327 0.88224197110117 -0.682384918748865 0.329519059640964 0.902810042912437 1.11949997618996 "PTEN MUT" "PF.4708671_IC_50" 0.779971133009234 0.942951760448544 0.0452163150760362 0.306081479360381 0.88224197110117 0.168323758663566 0.893917501281188 0.988301482344111 0.0239494566684001 "AKT2 MUT" "Rapamycin_IC_50" 0.514706590179987 0.851706582334351 1.39399462751677 0.306096675038216 0.88224197110117 1.86128504186008 0.470896625178636 0.929276781658587 1.56925756152628 "CDK4 MUT" "Temsirolimus_IC_50" 0.0119934457361709 0.196883163739249 1.82379897572255 0.306336722075327 0.88224197110117 0.569927612900125 0.0310464434477174 0.611360231173345 1.55848369815729 "KDM5C MUT" "PAC.1_IC_50" 0.716926116836585 0.921306561002511 -0.313992178883076 0.306755482760242 0.88224197110117 -0.742680740798475 0.928288131576414 0.994186152404781 -0.0748968803446036 "NF1 MUT" "CGP.082996_IC_50" 0.0269680314208463 0.304711306677526 1.06190700704226 0.306786375653067 0.88224197110117 0.417068762237217 0.13053966594747 0.824553892801908 0.830077224077191 "APC MUT" "Bryostatin.1_IC_50" 0.697974328857578 0.914925904921616 0.0903187560557709 0.306803277339125 0.88224197110117 0.233840460079653 0.22126315257061 0.864953081560998 0.330927289785367 "BRAF MUT" "AMG.706_IC_50" 0.32015898479406 0.762015213745527 0.183297227858294 0.306850131144622 0.88224197110117 0.190456560187066 0.584993107936332 0.949294892873838 0.11173334043547 "KDM6A MUT" "XMD8.85_IC_50" 0.0544412504618579 0.417163714712476 -0.990283764029568 0.306909288646342 0.88224197110117 -0.456246189135507 0.0632992074884066 0.70501719149803 -1.03197087849548 "NRAS MUT" "BX.795_IC_50" 0.659744391174321 0.902400992643984 -0.132469449499284 0.306989464041061 0.88224197110117 0.245315467593892 0.514094115295509 0.939635632721979 -0.199570409319289 "MLL_AFF1 MUT" "AZD.2281_IC_50" 0.0679713932558869 0.461747350209541 -1.93321691929135 0.307078615376948 0.88224197110117 0.832657352457438 0.939606792285235 0.994831655017307 -0.0714767486226811 "VHL MUT" "BIRB.0796_IC_50" 0.246272982051112 0.714668105985286 0.50196931599229 0.307181686134644 0.88224197110117 0.425962909123591 0.486612283393104 0.933639405738697 0.323108906309491 "CTNNB1 MUT" "Elesclomol_IC_50" 0.246814667748894 0.714668105985286 -0.707961953339289 0.307225655069807 0.88224197110117 -0.518514346945196 0.063649035879189 0.70501719149803 -1.16831497784812 "TP53 MUT" "PLX4720_IC_50" 0.0710583952540367 0.471770411289663 0.31453486060783 0.30729278224095 0.88224197110117 0.166950420589927 0.591900837887717 0.949294892873838 -0.0911492495112786 "MYC MUT" "PLX4720_IC_50" 0.297210615904008 0.748266144511455 0.323997333505153 0.307312128248407 0.88224197110117 0.283442313066597 0.426915771722922 0.922428741067589 0.234377642415627 "SOCS1 MUT" "JNK.Inhibitor.VIII_IC_50" 0.113108244423464 0.563938179281427 -1.28089782857145 0.307359155341405 0.88224197110117 -0.788381467991518 0.164467234435587 0.839927262232576 -1.13084870036442 "GNAS MUT" "Gefitinib_IC_50" 0.0930641343454284 0.521674050404563 0.970186515834924 0.307495959514369 0.882349472196159 0.530001175678036 0.0320889205538846 0.618827479917328 1.11297405298954 "SETD2 MUT" "JW.7.52.1_IC_50" 0.396047132952569 0.80402516584377 1.61890498305085 0.307872131208906 0.882951517291867 1.19446839521603 0.267564452577774 0.877052916121269 2.16787424696799 "CTNNB1 MUT" "Midostaurin_IC_50" 0.0356212802199106 0.347105523744792 -1.02510681657847 0.307946699210808 0.882951517291867 -0.384128151308543 0.0731725405466427 0.739487156743738 -0.892864581116441 "NF1 MUT" "Bosutinib_IC_50" 0.113023607000676 0.563938179281427 0.619583229702965 0.308323791580508 0.882951517291867 0.328141881799252 0.81750794556311 0.977383317127464 -0.0887941616112954 "BRCA1 MUT" "EHT.1864_IC_50" 0.315185134795141 0.760537253034044 -0.637691928251129 0.308425724067294 0.882951517291867 -0.644125012813181 0.362242965920313 0.91161229252998 -0.560308174739892 "FLCN MUT" "Bicalutamide_IC_50" 0.235648955781884 0.708702464036204 0.330237762237762 0.30843806129435 0.882951517291867 0.269659364874409 0.545375605931099 0.946853280734584 0.202912329085354 "AKT2 MUT" "Bryostatin.1_IC_50" 0.267965026924389 0.731489745211169 -0.530782399248124 0.30863669870939 0.882951517291867 -0.459116059961789 0.32139845327918 0.900918773778407 -0.459479125459547 "KRAS MUT" "Sorafenib_IC_50" 0.158704466546675 0.634889354685144 -0.576823469090909 0.308645757252018 0.882951517291867 -0.426210089300963 0.325807394135892 0.900918773778407 -0.456849152967523 "SETD2 MUT" "Z.LLNle.CHO_IC_50" 0.382618953319306 0.798569876743396 -1.12391512585034 0.308904377721353 0.882951517291867 -1.22033881497755 0.801270338018101 0.976360691959787 -0.3189196962635 "FGFR3 MUT" "GW.441756_IC_50" 0.202341224916566 0.674012093366938 -1.09780612713472 0.308962849796635 0.882951517291867 -0.856767928056461 0.226008019357292 0.86643108387559 -1.03076329172231 "SOCS1 MUT" "Metformin_IC_50" 0.147183777133279 0.619919550890177 -1.47744163498094 0.309065574466505 0.882951517291867 -0.967990930957308 0.395812672460005 0.916003810456352 -0.848032477817504 "EZH2 MUT" "AZD7762_IC_50" 0.467627622576288 0.831265195376303 0.583223067049805 0.309097328484036 0.882951517291867 0.635307127473989 0.832597691577338 0.981482581683432 0.154112989083806 "MYC MUT" "Parthenolide_IC_50" 0.255854148537978 0.720311238267775 0.378079897810218 0.309153236506319 0.882951517291867 0.31972274094987 0.290521387509224 0.891022884087089 0.381715569149679 "CDK4 MUT" "Sorafenib_IC_50" 0.657631859395331 0.901751651084414 0.58169085084746 0.309200219305997 0.882951517291867 1.27845255230103 0.403784199869323 0.917324899625757 1.13456390794494 "SMAD4 MUT" "Bortezomib_IC_50" 0.619465445811944 0.887477435756715 -0.400712135416665 0.309269990111046 0.882951517291867 0.693949131946692 0.98709089253642 0.998124818853736 -0.0132149589016567 "NF2 MUT" "Bosutinib_IC_50" 0.458923752178996 0.828966839128293 -0.296355728307924 0.309410361247264 0.882951517291867 -0.334987885829362 0.673362876667736 0.960256725054738 -0.166892774200939 "GNAS MUT" "AP.24534_IC_50" 0.129784235610734 0.591994759352302 1.33624706293706 0.30941916143137 0.882951517291867 0.807614771715405 0.29733405832191 0.894167310052 0.87145873653343 "RUNX1 MUT" "ABT.888_IC_50" 0.359649360449305 0.786601117838604 0.560529184478383 0.30947086960355 0.882951517291867 0.522846182265091 0.521144389458972 0.939635632721979 0.36441755490197 "SMO MUT" "Shikonin_IC_50" 0.173987066613759 0.651401757469953 -1.96832085517244 0.30949533535971 0.882951517291867 -1.23304468127685 0.114807748568384 0.799692247086917 -2.21729917899161 "EZH2 MUT" "BIBW2992_IC_50" 0.473885585856672 0.834460661638643 -0.610187853053439 0.309775955851967 0.883455252087923 -0.825429836827211 0.325836178513258 0.900918773778407 -0.771042927500345 "TP53 MUT" "AZD.2281_IC_50" 0.166730372900671 0.646248650615878 0.194898570384292 0.310236772898344 0.883455252087923 0.112939951169332 0.966700157432658 0.997173634484198 0.00555589658319913 "FLCN MUT" "PD.0332991_IC_50" 0.184178288109764 0.660385845878234 1.31297400414079 0.310266321842969 0.883455252087923 0.799900584539105 0.49708847078647 0.934008720636554 0.885821446649823 "TSC1 MUT" "ATRA_IC_50" 0.676201336677062 0.908661532914054 -0.510379952290084 0.310402745733351 0.883455252087923 0.977880643951175 0.731013389042524 0.96639568318693 0.367904985304766 "MYC MUT" "GNF.2_IC_50" 0.175158895598227 0.653333117096956 0.361404143382352 0.310521064152043 0.883455252087923 0.265426418382236 0.187609035498395 0.851001889249827 0.378875164622303 "KDR MUT" "BIBW2992_IC_50" 0.147658226682901 0.620905639758924 1.58833374841572 0.310735549834097 0.883455252087923 1.0658084937321 0.812193029935596 0.977383317127464 0.243538678823034 "NF1 MUT" "GDC.0449_IC_50" 0.731473342221763 0.928176068595523 0.091350377875136 0.310800545256419 0.883455252087923 -0.241331542343572 0.985797401743487 0.998124818853736 -0.00498823698415904 "BCR_ABL MUT" "DMOG_IC_50" 0.611544092628571 0.88496040166963 -0.45604290657439 0.310904432803711 0.883455252087923 0.981497708717259 0.323779820646228 0.900918773778407 0.851679351822212 "MDM2 MUT" "JNK.9L_IC_50" 0.122300618780348 0.580982694522287 0.676285085664336 0.310909254933234 0.883455252087923 0.346591583285924 0.108696306708112 0.794511851748756 0.693921947927033 "KDM5C MUT" "Roscovitine_IC_50" 0.378026162794967 0.795952477739693 -0.855074740484434 0.310963937719175 0.883455252087923 -0.869475369711894 0.337212051770289 0.905588216441469 -0.923964738935511 "FAM123B MUT" "GW.441756_IC_50" 0.315433982351808 0.760828136139708 -0.612587674285721 0.311224048177557 0.883455252087923 -0.60456282465141 0.323526315020462 0.900918773778407 -0.606577530587289 "MYCN MUT" "Sunitinib_IC_50" 0.321836015075536 0.762600226757161 0.528320591688313 0.311417817552591 0.883455252087923 0.411389926787428 0.160333935191252 0.838901067822678 -0.788029922033898 "EGFR MUT" "JNK.9L_IC_50" 0.295881792894739 0.747305163324792 0.305324910865678 0.311430156711345 0.883455252087923 0.23224885450276 0.178118680052114 0.848722027112292 0.409471037974734 "NF1 MUT" "GNF.2_IC_50" 0.170748232986717 0.649721929411943 0.505333428403757 0.311447119074645 0.883455252087923 0.359786531475291 0.243485564747465 0.875707386589409 0.505096674412357 "PIK3CA MUT" "Roscovitine_IC_50" 0.494795534368072 0.843282996121548 0.323851392335262 0.311503229044201 0.883455252087923 0.424553593099523 0.307552739036124 0.89718581932126 0.530164671195173 "MAP2K4 MUT" "IPA.3_IC_50" 0.630755015167346 0.893133815322257 0.278311472722309 0.311587055059559 0.883455252087923 0.492171933263085 0.27744394241071 0.884414807088842 -0.642247599242537 "CDK6 MUT" "Dasatinib_IC_50" 0.299413596081761 0.750519939825606 2.35232078498294 0.311680004669461 0.883455252087923 1.90320085125245 0.0564238313749744 0.697813103075383 4.59287287726626 "EP300 MUT" "AZ628_IC_50" 0.686727842649901 0.911748124009352 0.771997860544216 0.311900103999449 0.883455252087923 1.43787176114264 0.454509185550415 0.925809648901546 1.23634626501145 "VHL MUT" "ATRA_IC_50" 0.174009801068279 0.651401757469953 0.834756573359082 0.312026641202348 0.883455252087923 0.491442363602948 0.350679080365955 0.910340341961272 0.545030301177765 "AKT2 MUT" "Nutlin.3a_IC_50" 0.89489697530429 0.976746285090711 -0.110781009823181 0.31212283794205 0.883455252087923 -0.775390471089319 0.653297198361674 0.958313128388245 -0.367925855026997 "MS-HL MUT" "BX.795_IC_50" 0.832000596453084 0.958611936552287 0.0470040586432923 0.312213480770891 0.883455252087923 0.173033849706478 0.97398379445252 0.99742775226181 0.00696874920967024 "AKT2 MUT" "AZD7762_IC_50" 0.921516518941996 0.986140039233073 0.0723045092770321 0.312257956917769 0.883455252087923 -0.579971709325099 0.691290428826909 0.961100601384891 -0.267395699433774 "MYC MUT" "NVP.BEZ235_IC_50" 0.10247137495062 0.542988234448962 0.414676823655909 0.312260375449764 0.883455252087923 0.186121035456303 0.114384965914612 0.799692247086917 0.398278998679719 "EZH2 MUT" "JNJ.26854165_IC_50" 0.403521469964183 0.807711061141052 -0.477764144144148 0.312387222191161 0.883455252087923 -0.535246609847143 0.187254272256747 0.851001889249827 -0.712323329875745 "MLLT3 MUT" "AZD.0530_IC_50" 0.2948343183259 0.747036827777118 -0.680691726643594 0.312405296326044 0.883455252087923 -0.562356676628357 0.372179529162938 0.913948248824328 -0.575559435808928 "FGFR3 MUT" "Tipifarnib_IC_50" 0.694527522034322 0.913615900582776 -0.508887109175374 0.312413397819564 0.883455252087923 0.869840876312943 0.667709311932797 0.959230524020512 -0.545837606599884 "KDM5C MUT" "BAY.61.3606_IC_50" 0.654096903877303 0.900904870244158 0.429733340314143 0.312558989343226 0.883455252087923 0.674892172092237 0.376840404585138 0.914419412871569 0.792896102389529 "SMARCA4 MUT" "PHA.665752_IC_50" 0.261230371197226 0.724288808298587 0.892428720538709 0.312602897508976 0.883455252087923 0.799119842657239 0.538971615245009 0.944569766818715 0.8584486149145 "BRAF MUT" "GDC.0449_IC_50" 0.392852270156855 0.803073858340542 -0.150038667143537 0.312638977675274 0.883455252087923 -0.173473022888869 0.080171600729863 0.741811190933953 -0.359558404307475 "FAM123B MUT" "Camptothecin_IC_50" 0.00792811195710896 0.156679237330372 2.98451819142861 0.31265621633964 0.883455252087923 0.71980925298305 0.0671796883095824 0.717094725814184 1.84668920386445 "MYCL1 MUT" "TW.37_IC_50" 0.378794016647918 0.795952477739693 0.533882126410827 0.312993789660767 0.883800234284777 0.553629795945911 0.338306817408208 0.906340202363472 0.629636107402251 "EP300 MUT" "BMS.754807_IC_50" 0.702940375828176 0.915500829364901 0.508167868176533 0.313109776227943 0.883800234284777 1.12650168655029 0.687494203260509 0.961100601384891 0.522874659170454 "NF2 MUT" "Lenalidomide_IC_50" 0.0878417742292989 0.511142337432447 0.402929963442068 0.313279660461285 0.883800234284777 0.210602952604441 0.4491009409304 0.925809648901546 0.183316543324399 "KDM5C MUT" "AZD.2281_IC_50" 0.856690741729543 0.96514911547635 -0.191586998031498 0.313404266477019 0.883800234284777 0.812814182461104 0.968941281158222 0.997173634484198 -0.0360166225391149 "GNAS MUT" "JNK.Inhibitor.VIII_IC_50" 0.761975717314051 0.935915464447689 -0.123283208092485 0.313407209957304 0.883800234284777 -0.39122657341194 0.448300760069354 0.925809648901546 -0.31030688418627 "NRAS MUT" "Tipifarnib_IC_50" 0.238926223748645 0.710855542080976 -0.422228736448596 0.31342175764514 0.883800234284777 -0.248272265812432 0.560617069779754 0.949294892873838 -0.234811685060563 "HRAS MUT" "Metformin_IC_50" 0.243897978686708 0.713407040228131 0.688596360153246 0.313474917013518 0.883800234284777 0.557101370437104 0.338819345756346 0.90661482665324 0.554165048518573 "IDH1 MUT" "BIBW2992_IC_50" 0.247691524628162 0.714668105985286 1.55222805502845 0.313837029199071 0.883864813724032 1.28868635512266 0.630781468331341 0.952523560833852 0.600263476030316 "NF1 MUT" "XMD8.85_IC_50" 0.0704810568067137 0.469481816691404 0.899380392857143 0.313869828148411 0.883864813724032 0.433869548504513 0.150611655902352 0.831473272394224 0.796320156436098 "NRAS MUT" "Rapamycin_IC_50" 0.203513632239917 0.675665259036525 0.848467753106608 0.313943613532548 0.883864813724032 0.599250716219974 0.171607641195097 0.842832361237713 1.03533975676431 "CTNNB1 MUT" "Erlotinib_IC_50" 0.728104288142848 0.926270474573361 0.246724649446493 0.313963719395711 0.883864813724032 0.640689876214457 0.931078631868812 0.99422596912377 0.0667207652578782 "MSH2 MUT" "WZ.1.84_IC_50" 0.426184687665022 0.81941696345643 0.601038831615123 0.313995438272641 0.883864813724032 0.635625099863979 0.696949568039282 0.961100601384891 0.283614597190868 "AKT2 MUT" "BMS.754807_IC_50" 0.902212830292271 0.979694707150557 -0.10756394962406 0.314212967396344 0.883964208820841 0.734052467569208 0.72235017668089 0.965402608571648 -0.308780765385593 "MLL_AFF1 MUT" "Erlotinib_IC_50" 0.351199656067672 0.784966682190403 -1.13682770909092 0.314229817278166 0.883964208820841 -1.12737744605753 0.151124030106382 0.831473272394224 -1.71738538236031 "CDK4 MUT" "A.770041_IC_50" 0.988215786246088 0.997992312673585 0.0267978745762723 0.314380126330064 0.884106998713521 1.49125411259111 0.742761189597512 0.966725278648091 0.568749335189014 "EWS_FLI1 MUT" "ABT.888_IC_50" 0.984593239949051 0.996723172778267 0.00553047396268486 0.314633866268206 0.884540476836953 0.260107042287636 0.225269605140553 0.86643108387559 0.374895344903132 "TSC1 MUT" "AZD.2281_IC_50" 0.895512478401356 0.977104649723106 -0.139332076771653 0.314889843353124 0.884687296216629 0.806067728338077 0.574044754332457 0.949294892873838 0.523385065011485 "MAP2K4 MUT" "PF.02341066_IC_50" 0.344882900276677 0.780357971301188 0.890813269360266 0.314977531204124 0.884687296216629 0.875333122327338 0.519530646157417 0.939635632721979 0.725593424903868 "MS-HL MUT" "Nilotinib_IC_50" 0.81105954200423 0.952906441664184 0.052576566489541 0.314994228415287 0.884687296216629 0.17966443510287 0.183864463161462 0.851001889249827 0.287127701169377 "JAK2 MUT" "Erlotinib_IC_50" 0.455041811350152 0.828966839128293 -0.745358710462293 0.315153644367151 0.884687296216629 -0.899592048830442 0.385607646006152 0.915331032347709 1.04293255625839 "CDK6 MUT" "AKT.inhibitor.VIII_IC_50" 0.48314521674616 0.839032590911741 -0.377171223385688 0.315184169038331 0.884687296216629 -0.463457936969264 0.832429607745191 0.981482581683432 -0.117679101293803 "CDK6 MUT" "GSK.650394_IC_50" 0.259954601799058 0.723189643810247 0.834225620386645 0.315367793156325 0.884698577058724 0.480959958482566 0.456493689059776 0.925809648901546 0.587236208080048 "MYC MUT" "WO2009093972_IC_50" 0.589372618381057 0.876506729771444 -0.157396814449916 0.315387422020935 0.884698577058724 -0.263395411392448 0.622199727843072 0.950496524771391 -0.149818995281021 "NF2 MUT" "CMK_IC_50" 0.839114418173762 0.959325057190684 0.111553566433566 0.315765889145692 0.885352715342665 0.518414908568039 0.207621946335721 0.853446327418758 0.775625867968454 "MLLT3 MUT" "AZD.2281_IC_50" 0.362475830575812 0.787270200866664 0.318706109443675 0.315993052565771 0.885352715342665 0.264249400961168 0.37223701229168 0.913948248824328 0.287643846832615 "STK11 MUT" "NVP.BEZ235_IC_50" 0.154958301483999 0.630721638230745 0.477978411067198 0.316061569357145 0.885352715342665 0.24412714737485 0.104834725214409 0.788057589876989 0.556039514954226 "SMARCA4 MUT" "Pazopanib_IC_50" 0.569022598474893 0.872389778906173 -0.326622800674593 0.316189919077526 0.885352715342665 -0.486473490349132 0.747879334154039 0.968780465757047 -0.189244740643272 "BRCA1 MUT" "Epothilone.B_IC_50" 0.177863742852351 0.656868746076954 1.57675732460736 0.316215216990683 0.885352715342665 0.669744264893588 0.22046007743221 0.864474168037968 1.40930480282347 "TET2 MUT" "SL.0101.1_IC_50" 0.0182314277543296 0.247069557579196 -1.65919147435895 0.316306822221509 0.885352715342665 -0.62151383314015 0.777241563893938 0.972337708041191 0.235724923753918 "KDM6A MUT" "MS.275_IC_50" 0.129680478927768 0.591994759352302 -0.941147291052916 0.316375559510013 0.885352715342665 -0.517403659264611 0.305401171469577 0.896453471410625 -0.726979458844854 "MDM2 MUT" "Bicalutamide_IC_50" 0.168237148057944 0.647446641789 -0.272445679012344 0.316520844530849 0.885352715342665 -0.188294471273256 0.329845290539722 0.902810042912437 -0.180031958399092 "CDKN2a(p14) MUT" "Metformin_IC_50" 0.270490531670281 0.733000988154624 0.142016512786248 0.316557640620273 0.885352715342665 0.125085073299462 0.25358578766235 0.875707386589409 0.160946168967963 "KRAS MUT" "NU.7441_IC_50" 0.00408939999133547 0.104965206135984 0.488517250028014 0.316758336496438 0.885352715342665 0.159059224505046 0.163555184059439 0.839927262232576 0.267692318618851 "CDH1 MUT" "BI.2536_IC_50" 0.930844197680302 0.986689293492114 0.088775691780822 0.316974553397978 0.885352715342665 0.623778152277752 0.551148287950583 0.947060194029534 0.647724573720886 "KIT MUT" "BMS.509744_IC_50" 0.949351339968983 0.991438058591785 -0.0780701016949149 0.317005079328015 0.885352715342665 0.949171850531417 0.406128056716501 0.918000323669952 1.01096795780032 "MYC MUT" "Vorinostat_IC_50" 0.462264990722211 0.82931728663973 -0.155009206924711 0.317249396483284 0.885352715342665 -0.161379886236125 0.346251766528692 0.909317472748763 -0.189884567678977 "MSH2 MUT" "JW.7.52.1_IC_50" 0.425604572122828 0.819381892124907 0.883518797250864 0.317327104449719 0.885352715342665 0.672628511041346 0.490808207246883 0.933639405738697 0.791976577556863 "FAM123B MUT" "Bleomycin_IC_50" 0.855349872976551 0.964997350696397 -0.270062793706296 0.317347526812325 0.885352715342665 -1.20392287342785 0.951726799507089 0.995669074626174 -0.0876105458412929 "MLL_AFF1 MUT" "BIRB.0796_IC_50" 0.741324351103753 0.929570057037101 -0.284354857142865 0.317380988116554 0.885352715342665 0.837470242404799 0.965231049391927 0.997126446878798 0.0376090078409297 "ERBB2 MUT" "Docetaxel_IC_50" 0.0204413019055322 0.258971757807462 1.03057013401942 0.317491309071178 0.885352715342665 0.345122668946385 0.078005509894146 0.741811190933953 0.807035215148184 "PTEN MUT" "Methotrexate_IC_50" 0.511861332833199 0.850007572343239 0.183983627800537 0.3175284200547 0.885352715342665 0.217666273723729 0.92662038991984 0.994186152404781 0.0221910417935402 "PDGFRA MUT" "CEP.701_IC_50" 0.712176798569371 0.919646314953749 0.306098328244277 0.317654099968228 0.885352715342665 0.60547453740623 0.590446882152245 0.949294892873838 0.411105828431923 "KDM5C MUT" "BIBW2992_IC_50" 0.281839929819318 0.738375640008268 1.44522350094876 0.317663316201689 0.885352715342665 1.28724466461827 0.172398720153935 0.842832361237713 1.67856319983591 "JAK2 MUT" "PD.0332991_IC_50" 0.754522760771177 0.933900277236682 0.277031085062234 0.317850259273346 0.885352715342665 -0.704711566254414 0.728536007504469 0.965402608571648 0.322894158413541 "MET MUT" "Docetaxel_IC_50" 0.452023417687552 0.828509891052426 0.414135118413998 0.317972003593109 0.885352715342665 -0.412742508296343 0.634202477659124 0.952678811939519 0.25220025643807 "FLT3 MUT" "Erlotinib_IC_50" 0.760160259909788 0.935427915790332 0.304713917274941 0.318034380927469 0.885352715342665 0.911021757743907 0.996337994426913 0.999545005862799 0.0045114614667176 "BRCA1 MUT" "Bicalutamide_IC_50" 0.620526779445343 0.887709137927527 0.154084258289706 0.318053478926831 0.885352715342665 0.296039184812773 0.362529357363169 0.912074567349095 0.267444350979654 "MLL_AFF1 MUT" "Cytarabine_IC_50" 0.186762198614175 0.662394203631185 -1.85412719924097 0.318271915714519 0.885352715342665 -1.08081487983498 0.752931979245427 0.968780465757047 -0.414358548078556 "SETD2 MUT" "GW843682X_IC_50" 0.678628076531468 0.908837606441414 0.716814898305083 0.318275574019901 0.885352715342665 -0.899038261355777 0.540747011855665 0.944977216113766 1.10780971239513 "FLT3 MUT" "VX.680_IC_50" 0.0157254592384264 0.22780750573449 -3.66671116382249 0.318462493875818 0.885352715342665 -1.00107573219306 0.0395912794948513 0.64992634601437 -3.250388464808 "NF1 MUT" "ABT.263_IC_50" 0.852482456355602 0.964196154467744 -0.0881572928677025 0.318639355450391 0.885352715342665 -0.42873415720095 0.825946396239674 0.980121585382756 0.0983384370756598 "TP53 MUT" "IPA.3_IC_50" 0.389983990044172 0.801837403580487 0.156125993851522 0.318969326359363 0.885352715342665 0.158059277377823 0.837509557561969 0.981704379975756 -0.0373783958764795 "PIK3R1 MUT" "Tipifarnib_IC_50" 0.344863110273141 0.780357971301188 0.752599954086119 0.319306868551765 0.885352715342665 -0.527509791609266 0.443588115983951 0.925809648901546 0.598285705085543 "CDK4 MUT" "WO2009093972_IC_50" 0.984883078121602 0.996780241230536 -0.0104228364486007 0.319341667011551 0.885352715342665 -0.490745646331623 0.788318723700874 0.975265472692061 0.155143061084926 "EGFR MUT" "TW.37_IC_50" 0.213973516325429 0.688117861819268 0.383298040186916 0.319412784138043 0.885352715342665 0.279329062328123 0.740035659594141 0.96672489654949 0.103999176762694 "ERBB2 MUT" "PF.4708671_IC_50" 0.0317199085021851 0.329006499381264 -0.6408681712963 0.319520905941354 0.885352715342665 -0.304183781612754 0.0571976392190918 0.700127165484445 -0.614530409604931 "BRCA2 MUT" "ABT.263_IC_50" 0.506659727180246 0.847796212975596 -0.725019058823532 0.319567471980184 0.885352715342665 -0.982164379772069 0.306161816334151 0.896682870760742 -0.973141782017007 "SETD2 MUT" "AP.24534_IC_50" 0.714075053960011 0.91988693852899 -0.718295879310359 0.319616717846907 0.885352715342665 -1.76180681001019 0.744639330569711 0.96773833538847 -0.600949876233319 "KDM6A MUT" "Gemcitabine_IC_50" 0.864869167465236 0.967489995749939 -0.153319968482357 0.319715620547721 0.885352715342665 0.603378191986775 0.977324209005999 0.99742775226181 -0.0254018054513726 "CDH1 MUT" "PD.0325901_IC_50" 0.292017067924672 0.746611418788718 0.843208525551097 0.319765966024479 0.885352715342665 0.758899790831845 0.0608991939402283 0.702860976445846 1.40916948071682 "SMARCA4 MUT" "EHT.1864_IC_50" 0.245992625935401 0.714668105985286 -0.468924090909092 0.319772450488046 0.885352715342665 -0.396186955106763 0.387628672336101 0.915810119451161 -0.388347693078491 "MLH1 MUT" "Pyrimethamine_IC_50" 0.316155353192148 0.761258739353268 0.834579740484435 0.319851065529453 0.885352715342665 0.70760159383813 0.0514913157393818 0.689735105703544 1.64358864247621 "BRCA2 MUT" "PAC.1_IC_50" 0.289714961039023 0.745349408181059 -0.749628049036783 0.319896733148979 0.885352715342665 -0.592970399553952 0.18726925224474 0.851001889249827 -0.908772412683868 "TET2 MUT" "CEP.701_IC_50" 0.0571176635517274 0.429883025426179 -2.0304637680608 0.319943490176117 0.885352715342665 -0.788007764885991 0.145306517811252 0.831473272394224 -1.73508455080416 "TP53 MUT" "Pyrimethamine_IC_50" 0.376479538227722 0.795051761241315 -0.249408552083332 0.320146508391009 0.885352715342665 -0.247804779459176 0.520302651903063 0.939635632721979 -0.198496733510037 "MYCL1 MUT" "MK.2206_IC_50" 0.858123314841935 0.965651207814682 0.121510176785715 0.320249750173564 0.885352715342665 -0.537985764961653 0.728166773008698 0.965402608571648 0.25347023487104 "MDM2 MUT" "NSC.87877_IC_50" 0.454861563774961 0.828966839128293 -0.266798286713287 0.320352376853872 0.885352715342665 -0.34821456323711 0.563294426864307 0.949294892873838 -0.208713502141458 "CCND1 MUT" "PAC.1_IC_50" 0.0261531068447158 0.300179404454845 0.755062595151511 0.32036559576578 0.885352715342665 0.28507904835483 0.366171119430767 0.913948248824328 0.317802112270748 "CTNNB1 MUT" "Shikonin_IC_50" 0.126634912281937 0.587206821914858 -0.816582062081118 0.320411789085935 0.885352715342665 -0.446604112178507 0.0791811140746434 0.741811190933953 -1.02778392994777 "MLLT3 MUT" "PF.4708671_IC_50" 0.304852238082732 0.754224310561809 -0.306760763888892 0.320489781276855 0.885352715342665 -0.292409565388395 0.302784923805126 0.894219632947544 -0.320159342990172 "TP53 MUT" "AKT.inhibitor.VIII_IC_50" 0.188386198116512 0.663245512002727 -0.184610377762505 0.320504213675236 0.885352715342665 -0.125379058909596 0.753709997652845 0.96913420088708 -0.0464493905860826 "CDH1 MUT" "Doxorubicin_IC_50" 0.114944019501158 0.567167686753817 1.03162040551644 0.320633759774755 0.885352715342665 0.410734347210141 0.197511407372156 0.851001889249827 0.859851649460429 "NF1 MUT" "Axitinib_IC_50" 0.228994771128769 0.701276745653308 0.465573785547784 0.320796614411635 0.885352715342665 0.326317465822404 0.133951211394751 0.827361946088783 0.540871264054202 "FAM123B MUT" "X681640_IC_50" 0.0735946747395982 0.477424621155859 1.68707913008134 0.320829874577299 0.885352715342665 0.800892758949835 0.308809873797776 0.89718581932126 0.908491346816832 "CDH1 MUT" "AUY922_IC_50" 0.566503740175033 0.872389778906173 0.364605797535214 0.320866703975004 0.885352715342665 -0.4298928963391 0.888186336939815 0.988301482344111 -0.0915088540141271 "MLLT3 MUT" "SL.0101.1_IC_50" 0.500336967569381 0.845775049110478 -0.196699449944994 0.320927501982792 0.885352715342665 -0.252381664778843 0.41109447807488 0.921714070263062 -0.242385415941468 "KRAS MUT" "Doxorubicin_IC_50" 0.28014363495337 0.737882141891724 -0.250970876225669 0.321003912104874 0.885352715342665 -0.151208965712617 0.206230447842353 0.853446327418758 -0.319752342624297 "RUNX1 MUT" "Bleomycin_IC_50" 0.445298175742642 0.825606373270691 1.13048365734267 0.32112666467028 0.885416302060466 1.19660282537 0.693882911472992 0.961100601384891 0.62408566786926 "AKT2 MUT" "ATRA_IC_50" 0.214144092915183 0.688117861819268 0.879240009615385 0.321288497601194 0.885587568962198 0.552837627554634 0.304291601305493 0.895478998379977 0.642712351391584 "JAK2 MUT" "Cyclopamine_IC_50" 0.300984777115441 0.751119785777076 0.886559450171816 0.322261223003923 0.887367639666412 0.77215386008975 0.199572476629388 0.851001889249827 1.35959255434094 "PIK3CA MUT" "PHA.665752_IC_50" 0.46235736963104 0.82931728663973 0.285472873224337 0.322296652929372 0.887367639666412 0.383363413191899 0.541567044105392 0.945765861891114 0.266141184294397 "CDKN2a(p14) MUT" "JW.7.52.1_IC_50" 0.0295275960650528 0.31824585030793 -0.72151474850515 0.322316139589766 0.887367639666412 0.21399307476968 0.74581516449392 0.968371047127272 -0.124594371811483 "FLCN MUT" "AZD6244_IC_50" 0.844273425298278 0.960498931426639 -0.220945266045549 0.322651494157564 0.887367639666412 -1.01075052503377 0.528881482104169 0.943054040048671 -0.891684628150493 "KDM6A MUT" "GW843682X_IC_50" 0.0385681462562509 0.356053749378133 -1.29200840969751 0.322713669043424 0.887367639666412 -0.320340738564252 0.116402597629047 0.802617600577303 -1.10787371331707 "MAP2K4 MUT" "SL.0101.1_IC_50" 0.928412676318219 0.986689293492114 -0.0319317840834962 0.322771575868996 0.887367639666412 -0.305906274495995 0.743363944871544 0.966920292106991 -0.123828760431235 "ERBB2 MUT" "JNK.9L_IC_50" 0.0735333556309515 0.477424621155859 0.604196537116079 0.322901997908635 0.887367639666412 0.267900703468976 0.105901506349248 0.788168661441703 0.574337066133077 "CDK6 MUT" "Nutlin.3a_IC_50" 0.207259444149455 0.68021844918378 0.790740047084711 0.322956778795178 0.887367639666412 0.567043139266281 0.323442568821998 0.900918773778407 0.598484318037536 "KDR MUT" "BMS.754807_IC_50" 0.842350537372099 0.960245047977092 0.26503709001161 0.323099508652764 0.887367639666412 1.09853412037772 0.584621877763263 0.949294892873838 0.721826346855675 "BRAF MUT" "Tipifarnib_IC_50" 0.597452222100222 0.879232253518807 -0.167573924242423 0.323156062111366 0.887367639666412 0.229447005289794 0.779592177543339 0.972337708041191 -0.104581838396673 "ERBB2 MUT" "CGP.082996_IC_50" 0.802384324697218 0.951398556426701 -0.237542468714448 0.323309508239492 0.887367639666412 0.805089649659402 0.908823510580846 0.989610298855872 -0.110299428686191 "MDM2 MUT" "Pazopanib_IC_50" 0.657962323545702 0.901751651084414 -0.266093152910054 0.323323750179851 0.887367639666412 -0.504077600192323 0.958495963766718 0.99641548698706 -0.0284773853157095 "BRCA1 MUT" "SL.0101.1_IC_50" 0.122988127420791 0.582226844149279 0.941064980732193 0.323385738932882 0.887367639666412 0.528048335885121 0.198318768217153 0.851001889249827 0.751586251254213 "MDM2 MUT" "Tipifarnib_IC_50" 0.113335357440921 0.564199164480281 1.12954966843033 0.323444275608247 0.887367639666412 0.468101642277468 0.0749011020598634 0.741811190933953 1.2457285104871 "MYC MUT" "A.770041_IC_50" 0.0990117143687543 0.5374999166548 0.89609859157509 0.323462231126882 0.887367639666412 0.449051349922527 0.652336035703951 0.958313128388245 0.247241926996659 "TP53 MUT" "Bortezomib_IC_50" 0.374564391179965 0.794294736883779 0.244371199615928 0.323560994797598 0.887367639666412 0.232163884406351 0.757577345950213 0.969901216545994 0.088188040296413 "KIT MUT" "VX.680_IC_50" 0.702074564842936 0.915500829364901 -0.713479357142858 0.32372498610952 0.887367639666412 1.23594646883077 0.775006459453671 0.972151464181929 -0.555240892902445 "CDK4 MUT" "PLX4720_IC_50" 0.966018649395205 0.994434372972651 -0.0257126932038837 0.323796178352835 0.887367639666412 -0.529398583921088 0.892055837282942 0.988301482344111 -0.0778242327747443 "KRAS MUT" "Bortezomib_IC_50" 0.213399591087219 0.687913527566458 -0.620022071997347 0.323832735070245 0.887367639666412 -0.432289780138663 0.267925296862629 0.877052916121269 -0.574903894493183 "BRCA2 MUT" "CEP.701_IC_50" 0.0111866704209218 0.187804952756533 2.0984694541985 0.324129757556246 0.887806141038435 0.603839355387474 0.141697867877461 0.831473272394224 1.1152005573536 "SMARCA4 MUT" "Paclitaxel_IC_50" 0.52743593954804 0.855121165130409 -0.954744646258512 0.324192693997033 0.887806141038435 -0.649158601281691 0.277154431739752 0.884414807088842 -2.81346240340362 "FLT3 MUT" "ABT.263_IC_50" 0.0894715922394271 0.514272513671442 -2.13630107045013 0.32457912517708 0.888031387849438 -1.12668315299393 0.590257359333528 0.949294892873838 -0.591105982893209 "KDR MUT" "Obatoclax.Mesylate_IC_50" 0.80718960671944 0.952641225877339 0.325371542392563 0.324661456291908 0.888031387849438 0.963987028110775 0.747738187736214 0.968780465757047 0.415618041218813 "KRAS MUT" "SL.0101.1_IC_50" 0.89153612447637 0.975972789421281 0.0195767867596189 0.324927708964774 0.888031387849438 -0.128195361786363 0.274401498810974 0.883276444704699 -0.175870780828886 "KRAS MUT" "Mitomycin.C_IC_50" 0.360739859379608 0.786783098836476 -0.241387512687852 0.325023705649498 0.888031387849438 -0.213962864830584 0.366463835161204 0.913948248824328 -0.265257636274734 "FLT3 MUT" "NU.7441_IC_50" 0.188499917698799 0.663245512002727 1.33187736489154 0.325109296931623 0.888031387849438 0.880900985612584 0.156409390891728 0.837288218996252 1.38049642446713 "BRCA1 MUT" "Sunitinib_IC_50" 0.344104786920059 0.780249349533262 1.5812798537415 0.325244778407123 0.888031387849438 1.20843284244788 0.481101055668549 0.930456985059316 1.04374838542736 "MS-HL MUT" "WZ.1.84_IC_50" 0.294938703155044 0.747036827777118 0.301290370148659 0.325310613497658 0.888031387849438 0.23653019579955 0.394794061561549 0.915926348152589 0.263321505824969 "TP53 MUT" "KIN001.135_IC_50" 0.291381259308437 0.746611418788718 0.0994718589743597 0.325359125198052 0.888031387849438 0.0959722380676584 0.304808979105682 0.895767221521364 0.0990130736217594 "MSH6 MUT" "MS.275_IC_50" 0.227140343366879 0.699346740297147 -1.33214424570447 0.325443484711121 0.888031387849438 -0.900850428614949 0.301140448733174 0.894167310052 -1.17794583789579 "CTNNB1 MUT" "X681640_IC_50" 0.417912715573803 0.814099702076568 0.40270802066115 0.325595026134254 0.888031387849438 0.417874802938032 0.615573511574357 0.950126768674963 -0.25982782006013 "KDM6A MUT" "Z.LLNle.CHO_IC_50" 0.141590319027043 0.613849754216838 -0.684696078571425 0.325684005482939 0.888031387849438 -0.424295926065319 0.126322170702723 0.817150972850516 -0.754609714827452 "KDM5C MUT" "S.Trityl.L.cysteine_IC_50" 0.234685482828925 0.707962074581044 -1.2469122020548 0.32568790689369 0.888031387849438 -0.564283951050669 0.270651422350482 0.879734431423575 -1.17202996459721 "SMARCA4 MUT" "Elesclomol_IC_50" 0.290688517373803 0.746560070213055 -0.734396994219655 0.325783542506014 0.888031387849438 -0.563499721155073 0.808660141384174 0.977383317127464 0.181465956448413 "VHL MUT" "NSC.87877_IC_50" 0.275375353842468 0.734196492787437 -0.434488980836229 0.325862484427087 0.888031387849438 -0.386573049820752 0.253624406188936 0.875707386589409 -0.500068834290574 "CCND3 MUT" "Shikonin_IC_50" 0.244363457206062 0.713407040228131 1.1941302145329 0.326052288198792 0.888031387849438 0.848875117003736 0.266420540493226 0.877052916121269 1.11300891060969 "PIK3CA MUT" "Erlotinib_IC_50" 0.302765586187812 0.752537231223384 -0.522520849056605 0.326061992288128 0.888031387849438 -0.44805117683859 0.262311299882969 0.877052916121269 -0.610247047109366 "APC MUT" "JW.7.52.1_IC_50" 0.328258874658714 0.769809101094281 -0.80741933566434 0.3263318211826 0.888031387849438 -0.503556599814259 0.85690140377719 0.984749141685459 -0.1793811474534 "KDM5C MUT" "AS601245_IC_50" 0.593321669080632 0.878261059495448 -0.482606635253062 0.326383601454961 0.888031387849438 -0.709368644286159 0.464838482265163 0.929276781658587 -0.650637398358257 "EWS_FLI1 MUT" "QS11_IC_50" 0.0447535023055403 0.378529384738575 -1.02793949881377 0.32642499361665 0.888031387849438 -0.397467561691351 0.90781533960536 0.989534075687441 -0.0662346498568056 "STK11 MUT" "CCT007093_IC_50" 0.289963305132337 0.745349408181059 -0.220220470588237 0.326435925938468 0.888031387849438 -0.204226087437479 0.68496214339072 0.961100601384891 -0.0908436155967245 "CDK4 MUT" "NSC.87877_IC_50" 0.599514075324502 0.880481543941089 0.209247125435541 0.326446502661779 0.888031387849438 0.386204066967982 0.62142134559861 0.950496524771391 0.211972642311198 "MYC MUT" "MG.132_IC_50" 0.249006633025639 0.715488629021978 0.568896008791208 0.326474775512714 0.888031387849438 0.436180007713233 0.558348852915071 0.94928677421639 0.283799225768876 "HRAS MUT" "ABT.263_IC_50" 0.246890637385951 0.714668105985286 1.13139540471513 0.326629782364794 0.888180985052584 0.866507723301617 0.891188227155222 0.988301482344111 0.115810348004254 "PTEN MUT" "AS601245_IC_50" 0.373613985214128 0.793605788731564 0.188193092922047 0.326819148218033 0.888423892049081 0.169775369436011 0.296999306424962 0.894167310052 0.23608028507119 "BRCA1 MUT" "Gemcitabine_IC_50" 0.0662891535849101 0.458546662429304 3.72891454275748 0.327089057828801 0.888478156655981 1.33552838286977 0.0800363581808714 0.741811190933953 3.35333485417821 "EWS_FLI1 MUT" "RO.3306_IC_50" 0.639765560818454 0.895624997957207 -0.186391205714285 0.327257279925529 0.888478156655981 0.400238761289151 0.723413146991503 0.965402608571648 0.163540691405394 "BRCA2 MUT" "AZD6482_IC_50" 0.156374367399047 0.63139838220137 1.14273012673612 0.327275069584664 0.888478156655981 0.670450557785846 0.327695494182821 0.902810042912437 0.778495265552869 "MSH6 MUT" "S.Trityl.L.cysteine_IC_50" 0.207165539821552 0.680161611517635 -1.32332987328769 0.32739653126983 0.888478156655981 -0.562406437977737 0.18252322266954 0.851001889249827 -1.41383295990479 "ALK MUT" "JNK.Inhibitor.VIII_IC_50" 0.681763317462571 0.909861476478352 0.271240661577612 0.32753912595023 0.888478156655981 0.620089751473911 0.126972569658812 0.817150972850516 1.25003612809573 "CDK4 MUT" "Camptothecin_IC_50" 0.013775797193983 0.212607581866345 1.76194962235068 0.327572791726978 0.888478156655981 0.444815168435996 0.00279071386229796 0.277186416993605 1.97512366024175 "SMARCA4 MUT" "CI.1040_IC_50" 0.618977699086803 0.887477435756715 -0.283891494186047 0.327603900125882 0.888478156655981 -0.49739477304888 0.447753907305919 0.925809648901546 -0.43577904949348 "CDK6 MUT" "GNF.2_IC_50" 0.346904022826148 0.782020929432191 0.683836042093289 0.327712365697309 0.888478156655981 0.683391360669878 0.190378247591187 0.851001889249827 1.18307871845034 "MSH2 MUT" "TW.37_IC_50" 0.456818107862092 0.828966839128293 -0.504140635135138 0.327770688254666 0.888478156655981 -0.604154942232288 0.235282622031873 0.869962136993019 -0.77042313492251 "FBXW7 MUT" "ZM.447439_IC_50" 0.283961758554834 0.739564104351618 -0.372961570768667 0.3278395360164 0.888478156655981 -0.271915909030353 0.405877058610194 0.918000323669952 -0.292227233952289 "FGFR3 MUT" "WO2009093972_IC_50" 0.739098321099308 0.929570057037101 0.363849944700464 0.328058313977974 0.888799843330807 0.958424933322895 0.613190888346543 0.949930222127033 0.543592597741269 "BRCA1 MUT" "SB590885_IC_50" 0.181964751157083 0.658636992153339 1.21848106707319 0.328202160219458 0.888918385150659 0.748843295495371 0.172579508588512 0.842832361237713 1.08477214831813 "SETD2 MUT" "SL.0101.1_IC_50" 0.926385406762659 0.98643792569589 -0.0796620921305163 0.328748581613513 0.889879295815441 -0.74283814136702 0.682951720526827 0.961100601384891 -0.338495209443229 "MYCL1 MUT" "FH535_IC_50" 0.252301888580025 0.717470497840808 0.580268065255737 0.328823198953776 0.889879295815441 0.423867856188999 0.866501202759589 0.987077901072027 0.0891440748495074 "FGFR2 MUT" "Metformin_IC_50" 0.224930220992667 0.696758037194237 1.23724125475282 0.32888660965024 0.889879295815441 0.934879896668219 0.209686321942761 0.85423129595122 1.76903812001272 "MLH1 MUT" "JNJ.26854165_IC_50" 0.645941113890514 0.897100601386951 -0.215078914027151 0.328957744416405 0.889879295815441 -0.427339265710538 0.420999084398652 0.922428741067589 -0.354151468891161 "EWS_FLI1 MUT" "Embelin_IC_50" 0.399288302316576 0.805918367644724 -0.315609768683277 0.329197200841099 0.890255889363521 -0.311306065908993 0.565990765835692 0.949294892873838 -0.242863453494392 "TET2 MUT" "BIBW2992_IC_50" 0.625565072836092 0.890758415749171 0.535798070342196 0.329306063516684 0.890279193330799 1.04087463417521 0.198305692913072 0.851001889249827 1.60366329784521 "FBXW7 MUT" "Bicalutamide_IC_50" 0.232157689349534 0.704757001699372 0.16102382145782 0.329735014161543 0.891146722240843 0.12537876816519 0.309263731494431 0.89718581932126 0.133598821873786 "BCR_ABL MUT" "PF.562271_IC_50" 0.877579019426209 0.971802715567801 -0.118615157439446 0.329892003147389 0.891146722240843 -0.631106621027196 0.978503127409216 0.997696419805459 0.0207647131030699 "SETD2 MUT" "AUY922_IC_50" 0.248915493306556 0.715488629021978 1.54558602260872 0.329927983642371 0.891146722240843 0.883025804480623 0.128386611887608 0.820169751013594 1.94799248295839 "MSH2 MUT" "OSI.906_IC_50" 0.657748441311088 0.901751651084414 0.343367979448626 0.330179901676118 0.891404508101585 0.71675131573315 0.557859205789501 0.94928677421639 0.460582689393787 "TSC1 MUT" "Camptothecin_IC_50" 0.750565714883877 0.932697982453688 -0.506049785578744 0.330224167509764 0.891404508101585 0.982208354551197 0.834209406006265 0.981482581683432 0.293634022587052 "KDM6A MUT" "Sorafenib_IC_50" 0.221162482104397 0.693711036770013 -0.641219329360778 0.330385452897403 0.891568887019702 -0.486197146091058 0.521323578177605 0.939635632721979 -0.380935790661767 "MYCN MUT" "Bosutinib_IC_50" 0.480222239112126 0.836409826545359 0.304220784544864 0.330579317356665 0.891821056331878 0.357423261455357 0.369997956904503 0.913948248824328 -0.419992501923443 "CCND3 MUT" "PAC.1_IC_50" 0.125954925164167 0.586978030371663 1.32395020767891 0.330916386260296 0.892197708207643 0.705037214629509 0.167733160070168 0.84067330207935 1.15178863836837 "FLT3 MUT" "Obatoclax.Mesylate_IC_50" 0.947419881638487 0.990899019819731 0.0762098202443284 0.330934241072252 0.892197708207643 0.831236320876293 0.468486264069908 0.929276781658587 0.808910094541559 "BRCA1 MUT" "BI.D1870_IC_50" 0.0612290047358633 0.447070552416314 1.50942436711281 0.331020318493884 0.892197708207643 0.678727355104269 0.0910836558352533 0.764454987127048 1.28756796871593 "GNAS MUT" "Dasatinib_IC_50" 0.861340704228118 0.966384100200122 -0.396303560864614 0.331301419318718 0.892684437187359 1.81315879596204 0.877608639187787 0.987838063957761 0.305902068819017 "EGFR MUT" "Sunitinib_IC_50" 0.74952411840434 0.932547449642608 0.242120269230768 0.331530963934567 0.893031995966906 -0.538016318860071 0.783696285511517 0.974078058737889 0.183954992061883 "MLLT3 MUT" "WZ.1.84_IC_50" 0.262651859535913 0.724847082936025 -0.603150559440558 0.33164402242309 0.893065664990741 -0.4316383437747 0.181002085277636 0.848722027112292 -0.721500175081198 "CDK6 MUT" "Cisplatin_IC_50" 0.969783850772763 0.995036245554468 0.0211177044871775 0.332008295601113 0.89324261817647 -0.467087876894368 0.926937564312547 0.994186152404781 -0.0489063316471977 "MYCL1 MUT" "CCT007093_IC_50" 0.309308671527997 0.75674113273833 0.462371460674161 0.332059231181008 0.89324261817647 0.441601502716691 0.300207394755131 0.894167310052 0.539577514928159 "CDH1 MUT" "RDEA119_IC_50" 0.360106515518236 0.786601117838604 0.762574369739475 0.332085515698639 0.89324261817647 0.740873147569503 0.159527270940774 0.838901067822678 1.07711184841509 "FGFR3 MUT" "NVP.BEZ235_IC_50" 0.398728010188124 0.805918367644724 -0.922347727634169 0.332112051032395 0.89324261817647 -0.765111910299642 0.322174587553323 0.900918773778407 -1.02390902906272 "RUNX1 MUT" "OSI.906_IC_50" 0.402096078042205 0.806826766627389 0.766874265734274 0.332385499579086 0.893707424087757 0.837165197152544 0.92045689747429 0.993931766508607 0.102015992402061 "CDK6 MUT" "Etoposide_IC_50" 0.796974330078742 0.949420392411711 0.211673394997091 0.332794849456171 0.893796948203483 -0.518113681765785 0.68019406662413 0.961100601384891 0.339960221935365 "MYCN MUT" "WH.4.023_IC_50" 0.42954020389374 0.820918238409269 0.634789375930737 0.332832467868807 0.893796948203483 -0.707514232810758 0.241403856228559 0.875707386589409 -1.05858261347817 "KDM6A MUT" "QS11_IC_50" 0.803719325523615 0.951995809685991 0.108351302929086 0.3329889863685 0.893796948203483 0.311821031440789 0.78932222856197 0.975393509832241 -0.12041195668171 "MSH2 MUT" "AZ628_IC_50" 0.785347057149401 0.946055035513406 -0.303092100000002 0.333010179441511 0.893796948203483 -0.806451249329391 0.74100075769128 0.96672489654949 -0.324085919234351 "PTEN MUT" "Mitomycin.C_IC_50" 0.395893589035823 0.804008910182289 -0.220914874916308 0.333026969114496 0.893796948203483 -0.200660968863103 0.240545091458189 0.875707386589409 -0.321373692621231 "CCND2 MUT" "Tipifarnib_IC_50" 0.384372964006682 0.798569876743396 1.12688443554005 0.333092534766262 0.893796948203483 0.828682212919491 0.872320614594237 0.987643979884169 0.25038907887766 "NRAS MUT" "Metformin_IC_50" 0.465651856633469 0.830246489350841 -0.176883404940923 0.333235614952657 0.893796948203483 -0.227790207964328 0.802259662048137 0.976365695720597 0.0677110194916019 "CTNNB1 MUT" "Mitomycin.C_IC_50" 0.759653824837378 0.935323113597775 -0.177359753499409 0.333285358879212 0.893796948203483 0.438424376638851 0.959735577839949 0.99641548698706 -0.031966669814064 "BRCA1 MUT" "ABT.888_IC_50" 0.822373096478141 0.956993500507893 -0.119124185468452 0.333324568455122 0.893796948203483 -0.433922576994713 0.634506823084227 0.952678811939519 -0.235084464389643 "BRCA1 MUT" "JNK.9L_IC_50" 0.932778088381348 0.98681842896288 0.0520361126516468 0.333544626893746 0.893957390866165 -0.467847841165048 0.965645863802367 0.997126446878798 -0.0264266780986547 "EZH2 MUT" "CI.1040_IC_50" 0.575233799076593 0.872620551543038 0.450203180422268 0.333627207727995 0.893957390866165 0.69158438577659 0.488631126770068 0.933639405738697 0.489158653556713 "MSH2 MUT" "BX.795_IC_50" 0.445251697077454 0.825606373270691 0.547985832993897 0.333747700610796 0.893957390866165 0.535430006192634 0.953141854756399 0.99568364368633 -0.0371936320195587 "FLT3 MUT" "ATRA_IC_50" 0.0492206361573957 0.395285084229084 -1.96071714149142 0.333922190250063 0.893957390866165 -0.767863900140162 0.495201040817398 0.933639405738697 -0.600043665450171 "FAM123B MUT" "EHT.1864_IC_50" 0.51210582935059 0.850095676721979 -0.416349439461884 0.333962467609623 0.893957390866165 -0.609436839921663 0.627339283010705 0.952105511848497 -0.30440600823638 "SOCS1 MUT" "Nutlin.3a_IC_50" 0.916526915311043 0.984975746996111 0.138555753906248 0.333988359744841 0.893957390866165 1.17114571428198 0.979253673457343 0.997827228172038 0.0332233598465421 "SMARCA4 MUT" "PF.02341066_IC_50" 0.27403245022603 0.73402283606276 1.03131831986531 0.334576216854215 0.894671797886937 0.841630885170212 0.588544069672661 0.949294892873838 0.859280869442766 "CDKN2C MUT" "AS601245_IC_50" 0.164826899926618 0.641748223695 0.797520843033506 0.334617384867802 0.894671797886937 0.445881205414639 0.11063918583674 0.797376436030023 1.08014443656355 "FAM123B MUT" "JNK.Inhibitor.VIII_IC_50" 0.24128424008891 0.711340033600749 0.671510114722747 0.334807250652997 0.894671797886937 0.528802195581908 0.644815375890391 0.95666644725736 0.270317047359114 "CDKN2C MUT" "Paclitaxel_IC_50" 0.863356140536553 0.967259478252192 0.184867264604813 0.334831199487198 0.894671797886937 0.449772690806717 0.91018771480922 0.990141873133243 -0.147047413532467 "NRAS MUT" "Elesclomol_IC_50" 0.623264540621548 0.889762479546692 0.180148525136671 0.334849543012283 0.894671797886937 0.304918166058636 0.430412935101023 0.922428741067589 -0.310566246257129 "MLH1 MUT" "Sunitinib_IC_50" 0.966621152557511 0.994434372972651 -0.035360149305555 0.334949209715751 0.894671797886937 -0.606355980295796 0.560582599963599 0.949294892873838 0.43630284842222 "NF2 MUT" "Sunitinib_IC_50" 0.73688810499758 0.929060655945983 0.254790311188811 0.335105717570382 0.894671797886937 0.553805782817199 0.554717317169223 0.948071221654821 0.429022743687101 "BRCA2 MUT" "AKT.inhibitor.VIII_IC_50" 0.82840519331906 0.958015830101332 -0.142433734375002 0.335231633078046 0.894671797886937 -0.545925655795875 0.765494679350511 0.969901216545994 0.19334317760256 "APC MUT" "BMS.536924_IC_50" 0.155461059124772 0.630721638230745 -1.07700873426574 0.335414662884445 0.894671797886937 -0.550882222487493 0.710267244061387 0.962630898212352 -0.317128656091405 "GNAS MUT" "PF.4708671_IC_50" 0.471951675849553 0.833446576500274 0.284518387749939 0.335445132389997 0.894671797886937 0.37483357962831 0.464857077204698 0.929276781658587 0.294276356517741 "EP300 MUT" "A.770041_IC_50" 0.807236619806972 0.952641225877339 -0.442668515254233 0.335579631308473 0.894671797886937 1.41884332877542 0.553112563347971 0.947568031460906 1.02225024461948 "MYCL1 MUT" "Methotrexate_IC_50" 0.589246398855378 0.876506729771444 0.455250938403698 0.335585735082722 0.894671797886937 0.614366554659643 0.473262003187839 0.929276781658587 0.527495091731372 "MDM2 MUT" "Gemcitabine_IC_50" 0.0494313209382715 0.396208990300351 2.53602610758377 0.335662482150533 0.894671797886937 0.831043010131921 0.0825279602915521 0.745860856369627 2.0923388929603 "JAK2 MUT" "CGP.082996_IC_50" 0.351868240312648 0.784969887597353 0.883048202502839 0.335665626681598 0.894671797886937 0.761308953162257 0.183785835456351 0.851001889249827 1.53749539519806 "SMAD4 MUT" "A.770041_IC_50" 0.0273156137799277 0.307075906303212 -2.14984080246304 0.335874367456721 0.89495957317226 -0.784607469730551 0.163105627080002 0.839927262232576 -1.36784252380064 "BRCA2 MUT" "BMS.536924_IC_50" 0.0480029100116919 0.388972485231602 3.45633271864404 0.336384030384122 0.895360247563879 1.25624573059031 0.0148074838387607 0.490024700267999 4.08414940829797 "NRAS MUT" "SB.216763_IC_50" 0.226262488041508 0.698934663059699 0.308098056547618 0.336409724964441 0.895360247563879 0.245471534510255 0.0771888686112537 0.741811190933953 0.495112886625657 "KDM5C MUT" "PD.0332991_IC_50" 0.532825911868075 0.858279561609675 -0.711804676997227 0.336437242845555 0.895360247563879 -0.874347412828541 0.463716959111902 0.929276781658587 -0.7767632327607 "NF2 MUT" "Epothilone.B_IC_50" 0.70033360782599 0.915410639012359 -0.199696381294966 0.336568558360004 0.895360247563879 0.285299142248586 0.382949263509124 0.915134825237766 0.47599702642256 "JAK2 MUT" "AZD7762_IC_50" 0.675813316857079 0.908552538148308 0.28438128763736 0.33659392639962 0.895360247563879 -0.511453866965051 0.954895331715109 0.996100446818628 0.0381225399294132 "CDKN2C MUT" "Vinblastine_IC_50" 0.272049824840834 0.734000646544246 -0.69865733109405 0.336629643803152 0.895360247563879 -0.440618225175138 0.717818137835672 0.964721180904622 -0.231164536603362 "HRAS MUT" "AZD8055_IC_50" 0.787452496080478 0.946449577332088 0.172015832669323 0.336785277834085 0.895506003725901 0.47847756595016 0.687479889707059 0.961100601384891 0.247750256578678 "IDH1 MUT" "Mitomycin.C_IC_50" 0.836167642354656 0.959122768755193 0.324598175652179 0.337184118144905 0.896033659601065 1.17338114636385 0.890965251652163 0.988301482344111 -0.210461512597978 "MSH2 MUT" "Epothilone.B_IC_50" 0.585451164193865 0.876506729771444 -0.484099936340859 0.337311587094639 0.896033659601065 0.488667874263881 0.427918009428395 0.922428741067589 -0.692901397623741 "VHL MUT" "AP.24534_IC_50" 0.361450374537882 0.787160563087525 -0.898961872822284 0.337465863475597 0.896033659601065 -0.851270951050168 0.441409643916606 0.924472815010418 -0.772853244014916 "MLH1 MUT" "WH.4.023_IC_50" 0.0405483135054382 0.363921743983217 2.59767488194443 0.337629272054584 0.896033659601065 1.07257181383091 0.067789363206652 0.719539038493615 2.19637619399894 "FBXW7 MUT" "Paclitaxel_IC_50" 0.0905913096122129 0.515812267892501 -1.41442865470384 0.337701259701427 0.896033659601065 0.360656683405985 0.0692312025049912 0.723343893466855 -1.56807899610748 "NRAS MUT" "WH.4.023_IC_50" 0.850141835896504 0.963526482778845 0.151897282424244 0.3378158427263 0.896033659601065 0.694859617595053 0.757021025835566 0.969901216545994 -0.260980835241703 "SMARCB1 MUT" "NSC.87877_IC_50" 0.442176249199068 0.825166478070376 0.609239482758622 0.337917759555541 0.896033659601065 0.744213781901447 0.374153887000283 0.913948248824328 0.723565646864624 "TET2 MUT" "QS11_IC_50" 0.959922912730997 0.993583414773304 -0.0570459006968622 0.337960453109508 0.896033659601065 0.809592140781835 0.58599438864756 0.949294892873838 0.739405349976805 "CDK6 MUT" "Docetaxel_IC_50" 0.776177502439773 0.941591338606299 0.172784873233311 0.33813353345779 0.896033659601065 -0.435522320696571 0.752895492355617 0.968780465757047 0.184071805476577 "MYCL1 MUT" "PF.02341066_IC_50" 0.200168036802517 0.674012093366938 0.858117486394558 0.338194463998018 0.896033659601065 0.601072308136632 0.857397618696481 0.984898622336936 -0.123059272567206 "JAK2 MUT" "AICAR_IC_50" 0.383138133907954 0.798569876743396 -0.568971428571433 0.338307089274828 0.896033659601065 -0.559254168758588 0.444568062431238 0.925809648901546 -0.521646946375 "TP53 MUT" "VX.680_IC_50" 0.760918972042958 0.93574319967042 0.0969771744786497 0.338323817257087 0.896033659601065 0.210390580014125 0.706607446075167 0.962630898212352 0.13641250760881 "PTEN MUT" "BMS.536924_IC_50" 0.456929064226986 0.828966839128293 0.28973284437751 0.33871129941898 0.896033659601065 0.280598154405217 0.476337706896701 0.929855889225741 0.284131253672592 "NRAS MUT" "BMS.536924_IC_50" 0.819013423512304 0.95524539465489 0.125309970909091 0.338746678445652 0.896033659601065 0.403596910300317 0.92927164297056 0.99422596912377 0.0516333779044655 "FLCN MUT" "RO.3306_IC_50" 0.393199961204889 0.803073858340542 0.629725470588235 0.338820610712856 0.896033659601065 0.67170560373471 0.252723938636322 0.875707386589409 1.18755785885405 "CDK4 MUT" "IPA.3_IC_50" 0.374841689583026 0.794503352073234 0.651978666080848 0.338857792414664 0.896033659601065 0.592922738039455 0.667396955903772 0.959230524020512 0.311485654187113 "MET MUT" "AZD6244_IC_50" 0.153137699468295 0.627024393258611 1.0215585408805 0.339028447813643 0.896033659601065 0.623147620613946 0.0491825894883936 0.679896345274018 1.25037228080918 "BRCA2 MUT" "Sunitinib_IC_50" 0.597247094675272 0.879232253518807 0.883565568027214 0.339267848958213 0.896033659601065 -1.18347422369852 0.667837974948726 0.959230524020512 0.635986668185885 "RB1 MUT" "CHIR.99021_IC_50" 0.063950121256732 0.453627018275588 0.340320195779306 0.339335028384048 0.896033659601065 0.170496458620959 0.434909791138507 0.922569292988365 0.158115004323257 "FAM123B MUT" "PLX4720_IC_50" 0.199443503431251 0.674012093366938 1.2164724337812 0.339345499789118 0.896033659601065 0.804291640210167 0.594136155295297 0.949294892873838 0.465306340553413 "BRAF MUT" "Parthenolide_IC_50" 0.717043275050635 0.921306561002511 -0.136971368421052 0.339359611022573 0.896033659601065 0.363437097384268 0.502648516271161 0.934042323734638 -0.334380176646798 "STK11 MUT" "Etoposide_IC_50" 0.50775906280508 0.847951906124843 0.338117008960578 0.339370130727927 0.896033659601065 -0.317970150880097 0.986691212060567 0.998124818853736 -0.00858709654307548 "FGFR3 MUT" "Mitomycin.C_IC_50" 0.118968836966756 0.577057450057752 -1.99783430139371 0.339425591993388 0.896033659601065 -0.956956852908628 0.129850941032845 0.822543657141725 -1.88138438729485 "TSC1 MUT" "Obatoclax.Mesylate_IC_50" 0.284275200911918 0.740148947317134 1.74602859478263 0.339457866368276 0.896033659601065 1.14356790472375 0.168577030836276 0.84067330207935 2.1467687671369 "FAM123B MUT" "AZD.2281_IC_50" 0.590914790086224 0.876991017840199 0.466005532544384 0.339506053885551 0.896033659601065 -0.624982207347658 0.87301948604966 0.987739302532152 -0.12268728428708 "MAP2K4 MUT" "Obatoclax.Mesylate_IC_50" 0.270495596815444 0.733000988154624 -0.711595202400427 0.339804665409823 0.896347919305286 -0.4526783875789 0.201274515393857 0.851001889249827 -0.870181591917677 "MDM2 MUT" "Parthenolide_IC_50" 0.709777247512491 0.91855665481614 0.267574353741497 0.340075815591049 0.896347919305286 0.63624206332625 0.636360797511232 0.953101495776253 0.349894413262825 "KDR MUT" "AZD7762_IC_50" 0.144957580936091 0.619761064904019 -1.50690758015269 0.340251735839351 0.896347919305286 -0.771018155194113 0.0913283122780991 0.764454987127048 -1.60484353289266 "HRAS MUT" "PD.0332991_IC_50" 0.247905979463606 0.714944922080254 -1.02305886099585 0.340301044557285 0.896347919305286 -0.67682870157144 0.330866873287957 0.902810042912437 -0.804209243226919 "NF1 MUT" "AZD.0530_IC_50" 0.156021725305157 0.63139838220137 0.843725787456445 0.340301215923397 0.896347919305286 0.49466521287612 0.129285205277729 0.820170087278083 0.979920803114965 "CDKN2A MUT" "S.Trityl.L.cysteine_IC_50" 0.0595332809658094 0.439862785571841 -0.474270013796175 0.340447612230478 0.896347919305286 -0.139673821844348 0.363442506848896 0.912304381946028 -0.270167072020371 "JAK2 MUT" "VX.702_IC_50" 0.300487041038837 0.751119785777076 0.590088612716758 0.340702405310897 0.896347919305286 0.444332660510986 0.594030050069688 0.949294892873838 0.307678431255783 "CCND1 MUT" "OSI.906_IC_50" 0.174476585568158 0.652157641595459 0.545169125521884 0.34077020349957 0.896347919305286 0.362969343150327 0.492940865076864 0.933639405738697 0.296666829940598 "MYC MUT" "FH535_IC_50" 0.238673229132899 0.710855542080976 0.296783282858638 0.340954937651592 0.896347919305286 0.20683633998805 0.450784487266118 0.925809648901546 0.192317723395581 "EP300 MUT" "JNK.9L_IC_50" 0.359627519799677 0.786601117838604 -0.728060488773729 0.341176490547276 0.896347919305286 -0.594075547611158 0.342016331442122 0.907180409180092 -0.744994747814344 "GNAS MUT" "AZD8055_IC_50" 0.69224499508225 0.913066921534475 0.200228853707414 0.341247013956065 0.896347919305286 -0.373767666233702 0.802091370580806 0.976365695720597 -0.12246919828701 "MDM2 MUT" "BMS.708163_IC_50" 0.454290707207656 0.828966839128293 -0.290372902272728 0.341420032081814 0.896347919305286 -0.371519635779889 0.428234828371229 0.922428741067589 -0.309739862984105 "CDH1 MUT" "PF.4708671_IC_50" 0.906339004024509 0.981251818741413 0.0526651927437644 0.341450106906573 0.896347919305286 0.423909016607764 0.803983843866425 0.976660896667097 -0.123142126830907 "MET MUT" "CEP.701_IC_50" 0.0217756060151636 0.269402923906827 1.23399301273373 0.34147422410017 0.896347919305286 0.376791990500526 0.135298398343067 0.828937189282754 0.728779755786853 "MET MUT" "PD.0332991_IC_50" 0.489924456367194 0.84263880174142 0.434720318658278 0.341562643334714 0.896347919305286 -0.479393181672593 0.937495252576531 0.994831655017307 0.0460259590912757 "CDK6 MUT" "CEP.701_IC_50" 0.0682316197824482 0.462100070236188 1.13026957735042 0.341707226028977 0.896347919305286 0.432061603984972 0.119619823498395 0.807345933536413 0.874052609524327 "BRCA1 MUT" "BMS.754807_IC_50" 0.402873087338743 0.807551344312402 0.965938696335097 0.341994237336866 0.896347919305286 0.924243874067337 0.584054491913728 0.949294892873838 0.62474591333666 "KDM5C MUT" "MK.2206_IC_50" 0.284765721175991 0.740302864659114 1.10540740082642 0.342084945829536 0.896347919305286 0.782474238580148 0.209301441405028 0.853446327418758 1.25585957700929 "MSH6 MUT" "Roscovitine_IC_50" 0.485965141220515 0.840314723360475 0.586443749999996 0.342088202869384 0.896347919305286 0.707176090642292 0.468900505915488 0.929276781658587 0.605858533080372 "MLLT3 MUT" "Lapatinib_IC_50" 0.86994629500311 0.969505966359972 0.0938465602836881 0.342138278934842 0.896347919305286 0.469938690381911 0.71359862378048 0.962630898212352 -0.195016829277425 "CTNNB1 MUT" "ATRA_IC_50" 0.229080425287962 0.701297227501685 0.58228243589744 0.34220874425437 0.896347919305286 0.362773660985757 0.550961141860962 0.947060194029534 0.27658400386539 "CDK4 MUT" "PD.0325901_IC_50" 0.33821131230522 0.775937655536724 0.723349115796515 0.342276708647557 0.896347919305286 0.676138180092671 0.24312007352163 0.875707386589409 0.814850175609678 "STK11 MUT" "Bortezomib_IC_50" 0.907449747047263 0.981251818741413 0.118067302405499 0.342334619948489 0.896347919305286 0.785890057013504 0.647213730209904 0.957449344088104 0.503778366311491 "BRAF MUT" "BMS.509744_IC_50" 0.180607390692708 0.658636992153339 -0.524217396480333 0.342520264945659 0.896347919305286 -0.300720422792632 0.191992277386515 0.851001889249827 -0.647096711146403 "NRAS MUT" "JNK.9L_IC_50" 0.50606332693259 0.847796212975596 -0.146284293386244 0.342556931978985 0.896347919305286 -0.167266122620164 0.753120181914948 0.968780465757047 -0.0784807589127354 "FLT3 MUT" "JNK.Inhibitor.VIII_IC_50" 0.536497789532949 0.860198026510584 0.408823867684492 0.34270321217606 0.896347919305286 0.603688511381881 0.315937365631515 0.900294798053993 0.670952515807685 "CDK6 MUT" "Nilotinib_IC_50" 0.934366789238182 0.987517726433927 -0.0453640049145304 0.342766144946956 0.896347919305286 -0.422628998389767 0.590811023185378 0.949294892873838 -0.265998245457816 "MDM2 MUT" "Temsirolimus_IC_50" 0.445327234460118 0.825606373270691 0.555563775337188 0.342885628982673 0.896347919305286 -0.528012254665616 0.515128761506699 0.939635632721979 0.447300792206931 "BRCA2 MUT" "AG.014699_IC_50" 0.20213548438455 0.674012093366938 0.824130408577864 0.34290388837892 0.896347919305286 0.546360713761772 0.690030437142574 0.961100601384891 0.241332568216453 "CTNNB1 MUT" "CCT018159_IC_50" 0.216010191238881 0.688608753079032 -0.511805373831769 0.343228555294716 0.896347919305286 -0.365731208227582 0.535505879568072 0.943443271455699 -0.286784290481109 "GNAS MUT" "BI.D1870_IC_50" 0.7477911363686 0.932088853626601 0.184353673410403 0.343308504771776 0.896347919305286 -0.467988360426776 0.681125430246545 0.961100601384891 -0.223084771017295 "MDM2 MUT" "MK.2206_IC_50" 0.243246516401069 0.712490868125953 0.700499032543 0.343319444795648 0.896347919305286 0.454191960761516 0.166824445855063 0.84067330207935 0.804293271626241 "MLLT3 MUT" "Parthenolide_IC_50" 0.358711176680089 0.786601117838604 -0.470361280276815 0.343629997561122 0.896347919305286 -0.447153451971029 0.194201307920494 0.851001889249827 -0.722063606531925 "FGFR3 MUT" "RO.3306_IC_50" 0.440696281308345 0.824500931653809 0.802673124999994 0.343773567359239 0.896347919305286 0.939646706487848 0.410732531162621 0.921714070263062 0.852911455434508 "TP53 MUT" "Gemcitabine_IC_50" 0.585992552902337 0.876506729771444 0.194249118297758 0.34383330642594 0.896347919305286 0.232541753493806 0.983329118347498 0.998011368051263 0.00753541697445176 "RB1 MUT" "KIN001.135_IC_50" 0.555657685902576 0.86758015269001 -0.0733875494071148 0.34383706297159 0.896347919305286 -0.11861970793139 0.55943366704821 0.949294892873838 -0.0798519289563138 "CDKN2C MUT" "Gefitinib_IC_50" 0.217297493072677 0.689960327486037 0.713150644913627 0.343850393929014 0.896347919305286 0.492772775194899 0.68530408738495 0.961100601384891 0.226181388505672 "PDGFRA MUT" "AP.24534_IC_50" 0.253528488211278 0.718667891415372 -1.41871861282494 0.343865483401178 0.896347919305286 -1.05571632494715 0.6568180199516 0.958313128388245 -0.527475914797475 "KRAS MUT" "PAC.1_IC_50" 0.924461989443458 0.98643792569589 -0.0195129835427442 0.3439150090312 0.896347919305286 0.172415989313306 0.698637963916976 0.961100601384891 -0.0878759141855604 "MAP2K4 MUT" "CGP.60474_IC_50" 0.978026248508649 0.996276778834563 -0.0297297428896473 0.344213268937913 0.896347919305286 -0.760160215227218 0.944097975486944 0.995333788087439 0.0897920568778784 "STK11 MUT" "Doxorubicin_IC_50" 0.475714322670301 0.835134084317001 0.289924829339966 0.344239963635902 0.896347919305286 -0.239985954231936 0.938568929112909 0.994831655017307 0.0317420654162506 "NOTCH1 MUT" "A.443654_IC_50" 0.430875634363923 0.820918238409269 -0.490609475598082 0.344240196091533 0.896347919305286 0.400711254884522 0.15223890511265 0.832065593775825 -1.04889230436616 "MYCL1 MUT" "Imatinib_IC_50" 0.558528410461852 0.869163612542691 -0.335481080773608 0.344305986440211 0.896347919305286 -0.542226091472462 0.142020524661599 0.831473272394224 -0.925423606270066 "HRAS MUT" "Bexarotene_IC_50" 0.520546068303603 0.852599738673405 0.463454229020975 0.34430938149499 0.896347919305286 0.610173816228035 0.135567770618487 0.828937189282754 1.02823165423403 "MS-HL MUT" "WH.4.023_IC_50" 0.265194906186502 0.726697783882931 0.679242497655395 0.344322500746283 0.896347919305286 0.503652118993174 0.0428823325840498 0.658180729724545 1.30054602554416 "ALK MUT" "RDEA119_IC_50" 0.534184527168892 0.858348613314082 -0.841847206349196 0.344552637460865 0.896347919305286 -1.16021645881657 0.0129621983208867 0.477665075882967 -3.53063109637179 "JAK2 MUT" "BI.2536_IC_50" 0.54527640715367 0.862633715268747 -0.795830877551027 0.34468061019246 0.896347919305286 -0.732001526181656 0.996372071104807 0.999545005862799 -0.00765735888246413 "VHL MUT" "BI.2536_IC_50" 0.124489417780865 0.585102471530182 1.56834425342466 0.344736114634393 0.896347919305286 0.586300247756552 0.144732231903862 0.831473272394224 1.80493910018184 "MLL_AFF1 MUT" "Docetaxel_IC_50" 0.597878350976229 0.879232253518807 0.675332911196912 0.344818712913008 0.896347919305286 0.92298500178792 0.707759319787176 0.962630898212352 0.46785847884459 "SMARCA4 MUT" "PD.0325901_IC_50" 0.570327076348937 0.872389778906173 0.407212515090544 0.345093037420448 0.896347919305286 0.633787783158541 0.669589656107391 0.959230524020512 0.306014633955002 "APC MUT" "AG.014699_IC_50" 0.000195781983837182 0.0153870778624603 1.03724612142858 0.34530149625693 0.896347919305286 0.245590575831549 0.16240231245593 0.839927262232576 0.440538478669224 "EWS_FLI1 MUT" "BX.795_IC_50" 0.031208662529947 0.327230380080826 -0.930926512151768 0.345377389089549 0.896347919305286 0.336974773914178 0.254343127019302 0.875707386589409 0.508405738833437 "BRAF MUT" "Rapamycin_IC_50" 0.736523356264812 0.928872455997232 -0.229661652329748 0.345411557702648 0.896347919305286 -0.60515333318513 0.141207113625417 0.831473272394224 -1.31251870250171 "EZH2 MUT" "RDEA119_IC_50" 0.462374446084174 0.82931728663973 0.862745811133213 0.345447635370659 0.896347919305286 0.995803151362768 0.279667787082071 0.88601917827756 1.08289580378024 "MS-HL MUT" "Bortezomib_IC_50" 0.229822792476993 0.702601108429664 0.474617084942082 0.345464924745316 0.896347919305286 0.308314899783815 0.947951985830992 0.995668765770473 0.0273962746301857 "NOTCH1 MUT" "CCT018159_IC_50" 0.889042265118593 0.975527896272722 0.0991291284403671 0.345519972155029 0.896347919305286 0.621154965804869 0.699937675404936 0.961100601384891 0.273955293919835 "VHL MUT" "Paclitaxel_IC_50" 0.145013342289219 0.619761064904019 1.70889315068493 0.345546232900333 0.896347919305286 0.495895054397325 0.126038452469419 0.817150972850516 2.09522891634208 "CCND1 MUT" "AZD7762_IC_50" 0.426192074654676 0.81941696345643 0.291361000717131 0.345578494530399 0.896347919305286 -0.272387301638826 0.682083751629778 0.961100601384891 -0.147312078055302 "PIK3CA MUT" "Metformin_IC_50" 0.280163306944119 0.737882141891724 0.22702690691661 0.345588873155626 0.896347919305286 0.187175540018626 0.155989522069249 0.837288218996252 0.321495809996536 "ALK MUT" "AP.24534_IC_50" 0.404877479008428 0.807904911469051 1.63256768965517 0.345718690777949 0.896347919305286 1.67157594032954 0.782832966210048 0.973856308110695 0.715881057345643 "CTNNB1 MUT" "Cyclopamine_IC_50" 0.364195885375875 0.787347531164349 -0.552938194444446 0.345825272053971 0.896347919305286 -0.523203123348576 0.521236989050063 0.939635632721979 -0.436179368354724 "RB1 MUT" "Bicalutamide_IC_50" 0.064265028213786 0.454771088100903 0.149912242187037 0.345882706841484 0.896347919305286 0.0746886810622863 0.230491355817701 0.868523106840304 0.103412656969788 "PDGFRA MUT" "Elesclomol_IC_50" 0.888728400587607 0.975527896272722 0.136941085877863 0.346193430645358 0.896379758788838 0.76578289753727 0.205590983836433 0.853446327418758 1.18720154434448 "MLL_AFF1 MUT" "BIBW2992_IC_50" 0.694709061436393 0.913615900582776 0.527303102466791 0.346237982678525 0.896379758788838 1.23213513206257 0.656496697913876 0.958313128388245 0.558397575943897 "ALK MUT" "CHIR.99021_IC_50" 0.283417383129657 0.739564104351618 1.08961298275862 0.346259542018372 0.896379758788838 0.905943144592927 0.346428174486371 0.909317472748763 1.30048273592097 "STK11 MUT" "NU.7441_IC_50" 0.99070885266682 0.998036562927507 -0.00355529235999246 0.346372289080349 0.896379758788838 -0.252242939361608 0.407237848692378 0.919806544821214 -0.260221503311301 "TSC1 MUT" "Bleomycin_IC_50" 0.931444252142174 0.986689293492114 -0.200985217391303 0.346399654561794 0.896379758788838 -1.79389384314116 0.767908976717297 0.969901216545994 0.662420068653959 "FAM123B MUT" "ATRA_IC_50" 0.0962006607544091 0.529998801588032 1.4384494348659 0.347203329102798 0.898014138152676 0.641128912137968 0.28877596016862 0.889281028047524 0.817189059340444 "EP300 MUT" "SB.216763_IC_50" 0.301289827270991 0.751119785777076 0.870589798177069 0.347233481636785 0.898014138152676 0.765994214293567 0.380821797870926 0.915134825237766 0.708335494873354 "ERBB2 MUT" "Z.LLNle.CHO_IC_50" 0.829895541497672 0.958015830101332 0.226331125142207 0.347406844470951 0.898155393074092 0.931458436808276 0.913396799655877 0.99082410867764 0.114483124188559 "ERBB2 MUT" "Imatinib_IC_50" 0.540517613315069 0.861616652986104 -0.428371406779662 0.347601847388976 0.898155393074092 -0.658675174700122 0.565964655159474 0.949294892873838 -0.440452301618274 "MDM2 MUT" "Z.LLNle.CHO_IC_50" 0.635033584712242 0.89462773886888 0.388608223367699 0.347623686786702 0.898155393074092 0.707323573921851 0.354399630595826 0.91150394419969 0.738510782921248 "CCND2 MUT" "Obatoclax.Mesylate_IC_50" 0.780095633200253 0.942973910228862 -0.37221877700348 0.347692629364793 0.898155393074092 -0.913818596038552 0.839944078969839 0.981985848511457 -0.315576537525145 "CDH1 MUT" "AKT.inhibitor.VIII_IC_50" 0.295735202589902 0.747204646998838 0.562245844677142 0.348146702355187 0.898164485202886 0.439126859241224 0.0472137200228014 0.673636396626734 1.11467955407602 "MLL_AFF1 MUT" "Embelin_IC_50" 0.194424355304785 0.66977606650962 -1.31492280000001 0.348154826749866 0.898164485202886 -0.769784599560697 0.263355884362871 0.877052916121269 -1.12857028202086 "FAM123B MUT" "Midostaurin_IC_50" 0.231073569609483 0.703760072600075 1.00445412651646 0.348188983147844 0.898164485202886 0.605649050569856 0.25094979830629 0.875707386589409 0.887418159154125 "NRAS MUT" "Cyclopamine_IC_50" 0.609661165775493 0.884443710620525 -0.170888644688645 0.348386133240051 0.898164485202886 -0.300450048745746 0.768567938982541 0.969901216545994 -0.111310556739884 "NF2 MUT" "ABT.263_IC_50" 0.995444466497244 0.998977896287767 -0.00276775224572561 0.348422421505504 0.898164485202886 -0.412450920500348 0.0626034349880366 0.704665533750003 -0.835220265859778 "CDH1 MUT" "XMD8.85_IC_50" 0.390792092237664 0.801837403580487 0.704341349480968 0.348472919883109 0.898164485202886 0.680511401253782 0.445404970608595 0.925809648901546 0.632003133778464 "NF2 MUT" "Cisplatin_IC_50" 0.726302457284019 0.92547791524492 0.129249303805773 0.34847911237282 0.898164485202886 0.300083029989166 0.176871206996507 0.848618686837376 0.510138925328225 "MLLT3 MUT" "Thapsigargin_IC_50" 0.938701026558746 0.989080507581691 0.0491945123329907 0.348505215179501 0.898164485202886 0.454900362871103 0.8411299680847 0.982150602679453 0.130164508277072 "FLT3 MUT" "Embelin_IC_50" 0.204081267613202 0.675781408528279 -0.911634834205952 0.348652835674616 0.898284256926681 -0.541667256660188 0.300104194079797 0.894167310052 -0.740873487547025 "MSH2 MUT" "Bosutinib_IC_50" 0.135148477678396 0.602536962982847 -1.02066755027472 0.349134231396782 0.898977201188407 -0.5247274004426 0.29421967972237 0.894167310052 -0.668038041250775 "TET2 MUT" "Bleomycin_IC_50" 0.741431593716634 0.929570057037101 0.629936672473864 0.349412491807231 0.898977201188407 1.47041000983272 0.109951653482751 0.797127048636987 3.59867728683438 "MLL_AFF1 MUT" "FH535_IC_50" 0.663286105747238 0.903526384925934 -0.490265935652178 0.349552301695935 0.898977201188407 -0.918569507650827 0.408066356635175 0.920903133902018 -0.897425759709595 "FLT3 MUT" "Cyclopamine_IC_50" 0.718536505341236 0.92132587844031 -0.309175257731956 0.349558186905053 0.898977201188407 0.745621746415306 0.599845286852668 0.949657634568742 0.454031778264013 "GNAS MUT" "Bryostatin.1_IC_50" 0.316684949724543 0.761258739353268 -0.402503029982363 0.349617951311961 0.898977201188407 -0.354302367377212 0.342745907014509 0.907180409180092 -0.367193344832274 "MDM2 MUT" "Dasatinib_IC_50" 0.876459398652007 0.971594429690931 -0.274155305841925 0.349633814404139 0.898977201188407 1.35890111301004 0.618655720036007 0.950394619652337 0.764609574239983 "MAP2K4 MUT" "Lapatinib_IC_50" 0.377438031914621 0.795261485512158 -0.791028368055555 0.350099405379642 0.898977201188407 -0.727683318624307 0.290924219608451 0.891022884087089 -0.967838819235497 "KIT MUT" "Lapatinib_IC_50" 0.887191281782984 0.975214727041194 -0.179295413793103 0.350134202863512 0.898977201188407 1.05522057274232 0.56897470959722 0.949294892873838 0.637045892562253 "SMARCB1 MUT" "AS601245_IC_50" 0.190055741064185 0.664991779417723 -1.67080235130436 0.350155345647546 0.898977201188407 -0.951209472965717 0.256977231484971 0.876763270387258 -1.44689237679691 "HRAS MUT" "ZM.447439_IC_50" 0.486931674785812 0.840863415759626 -0.499213671905699 0.350474277229469 0.898977201188407 -0.534857195215728 0.449791163857859 0.925809648901546 -0.511549453410602 "GNAS MUT" "Embelin_IC_50" 0.979938909770929 0.996332002460735 -0.0114840388007052 0.350498074939593 0.898977201188407 -0.340462488866344 0.665683744805958 0.959206771190239 -0.196683278399256 "TSC1 MUT" "IPA.3_IC_50" 0.527457914940252 0.855121165130409 0.923766062608706 0.350535447856675 0.898977201188407 1.14641608882783 0.261243716680022 0.877052916121269 1.52142255234599 "KRAS MUT" "FH535_IC_50" 0.0186951223185619 0.249671250091952 -0.4446809504065 0.35053906596894 0.898977201188407 -0.160028988830147 0.218639117605102 0.861461403483102 -0.255175059619476 "FBXW7 MUT" "IPA.3_IC_50" 0.0939066801071685 0.52451901008287 -0.750770557575751 0.350846186002881 0.898977201188407 -0.352278080181166 0.36799290051885 0.913948248824328 -0.390397926453688 "MLLT3 MUT" "MS.275_IC_50" 0.257597614712953 0.721889937062894 0.798125322807021 0.350888196880592 0.898977201188407 0.541036152977956 0.24198219404995 0.875707386589409 0.904883055564798 "MLL_AFF1 MUT" "BI.2536_IC_50" 0.135455194423664 0.602620739586366 -2.39790636610172 0.350899000672744 0.898977201188407 -0.907795704745808 0.0934352302115086 0.768046723169691 -2.80092733495776 "SMARCA4 MUT" "Tipifarnib_IC_50" 0.904773573836311 0.980404570472143 -0.0815325656922579 0.350904271721014 0.898977201188407 -0.42058256806417 0.662710004717608 0.959019173936706 -0.328727837933824 "CDH1 MUT" "Axitinib_IC_50" 0.437624469960681 0.823808548892323 0.491638005278303 0.350949765591958 0.898977201188407 -0.506548317775046 0.600800632537519 0.949657634568742 0.313019538751236 "MSH6 MUT" "CCT018159_IC_50" 0.353653096191755 0.785062892590933 -0.65871032110091 0.351095965392664 0.898977201188407 -0.614784425262681 0.184585711884798 0.851001889249827 -0.948293801700066 "TP53 MUT" "AUY922_IC_50" 0.422861113429677 0.817463985278398 0.133531637870855 0.351099533965845 0.898977201188407 0.108885907691498 0.895092875700026 0.988301482344111 0.0226660080681532 "FLCN MUT" "NSC.87877_IC_50" 0.224217090725433 0.696139064632428 0.610712547660307 0.351105102032807 0.898977201188407 0.460204965236805 0.649893233676739 0.957867556929346 0.297639509402281 "JAK2 MUT" "AUY922_IC_50" 0.11261330406843 0.563938179281427 1.14120056917295 0.351148734480642 0.898977201188407 0.451135805207051 0.163289557015488 0.839927262232576 1.04213969379587 "MET MUT" "Z.LLNle.CHO_IC_50" 0.608317645598348 0.884201147390986 -0.659990500000002 0.351523272547206 0.899500121877201 -1.09747189542247 0.949252746660022 0.995668765770473 0.0798847158113082 "BRCA2 MUT" "Paclitaxel_IC_50" 0.26234169337061 0.724847082936025 2.06904889491524 0.351595425868333 0.899500121877201 0.752471534682408 0.0863596442718894 0.751185113397307 3.19946741100849 "MDM2 MUT" "Lapatinib_IC_50" 0.158496031610908 0.63438594466745 -1.13116665505226 0.351672131776663 0.899500121877201 -0.644963535886612 0.671481926683662 0.960241983012847 -0.299358028259898 "CDK6 MUT" "PF.562271_IC_50" 0.16627287163078 0.645397453213705 0.713139102385104 0.35191026406329 0.899500121877201 0.392086334566589 0.158241951147582 0.83854630828105 0.755186018586301 "SETD2 MUT" "NU.7441_IC_50" 0.549638947030791 0.864873049004332 0.606376674556227 0.35191278934244 0.899500121877201 0.832256203474033 0.494320632575175 0.933639405738697 0.667271313130897 "KDR MUT" "Mitomycin.C_IC_50" 0.337545424943211 0.775411515499394 -1.22969383681764 0.351960694012304 0.899500121877201 -0.933986873548895 0.12592855970598 0.817150972850516 -1.9261665205863 "MYCL1 MUT" "BMS.708163_IC_50" 0.274729681246341 0.73402283606276 -0.595820397752813 0.352149473676503 0.899629044151136 -0.51089649773436 0.700463191131807 0.961100601384891 -0.240310500273551 "SMARCA4 MUT" "AZD8055_IC_50" 0.885399395501718 0.974449243426767 -0.0653482969818912 0.352458891034343 0.899629044151136 -0.326414022989615 0.841427194630749 0.98221804883224 0.100224686451116 "FLCN MUT" "Epothilone.B_IC_50" 0.29258042014564 0.747036827777118 1.10293912937062 0.352519262056751 0.899629044151136 -0.554666252302686 0.435740221802029 0.922569292988365 1.02436654340258 "PIK3R1 MUT" "BMS.509744_IC_50" 0.047524933988498 0.386864288498488 1.54306311643835 0.352768184012057 0.899629044151136 0.536901325271248 0.0428392971889742 0.658180729724545 1.53440160273053 "EWS_FLI1 MUT" "Bleomycin_IC_50" 0.0804319927782131 0.492632088181594 -1.50650787781733 0.352807237737701 0.899629044151136 -0.695404552411273 0.880665288256205 0.988301482344111 -0.142568303695524 "CTNNB1 MUT" "GSK.650394_IC_50" 0.0680064783328543 0.461747350209541 -0.992213545670236 0.352971083193463 0.899629044151136 -0.326331547175172 0.294251313908978 0.894167310052 -0.638328078834625 "CDKN2a(p14) MUT" "X17.AAG_IC_50" 0.00551781736303221 0.12728243117166 -0.543745758400609 0.352976123997688 0.899629044151136 -0.167525410761852 0.557236636414765 0.949136321936116 0.113435312282043 "MYCL1 MUT" "Cyclopamine_IC_50" 0.212659859522449 0.687025177307701 0.758968750000002 0.353202916603429 0.899629044151136 0.52714783299162 0.901445666370845 0.988746233284632 0.0788078223423069 "MLLT3 MUT" "JNK.Inhibitor.VIII_IC_50" 0.362911260210475 0.787293170741334 -0.249209755511897 0.353518237194988 0.899629044151136 -0.242562499333065 0.244065590283716 0.875707386589409 -0.337856946874695 "APC MUT" "Roscovitine_IC_50" 0.167168928640543 0.646614658212831 -0.708932449045612 0.353631778576305 0.899629044151136 -0.436401374702688 0.355480574060858 0.91161229252998 -0.576289694427553 "APC MUT" "Z.LLNle.CHO_IC_50" 0.811953386442919 0.953452072590185 0.1327140169059 0.353719781724717 0.899629044151136 0.488025971224969 0.437643431386832 0.922569292988365 0.499468425767499 "PTEN MUT" "CHIR.99021_IC_50" 0.4830950272993 0.839032590911741 -0.116955093834901 0.353767961009514 0.899629044151136 -0.149715603428634 0.561193441316886 0.949294892873838 0.101819053950336 "BRCA2 MUT" "SB.216763_IC_50" 0.252664153913474 0.71782160937478 0.747643745098016 0.353795913961377 0.899629044151136 0.58900170681358 0.365342838713908 0.913948248824328 0.576965391401825 "MYCL1 MUT" "Dasatinib_IC_50" 0.096873531458491 0.531070267211641 2.67109008045979 0.353977360023364 0.899629044151136 1.24962921053896 0.733621356775557 0.96672489654949 -0.497852392582091 "SMARCB1 MUT" "IPA.3_IC_50" 0.319935733311341 0.761755830439148 -1.45362445913045 0.3540682978991 0.899629044151136 -1.13399235238237 0.233211399404967 0.869962136993019 -1.63912724888261 "FGFR3 MUT" "Parthenolide_IC_50" 0.930123245498539 0.986689293492114 0.099193367003366 0.354096139918706 0.899629044151136 0.970248243795121 0.866567186785314 0.987077901072027 0.195749978855463 "MSH6 MUT" "AICAR_IC_50" 0.856357077308628 0.96514911547635 -0.118133621651787 0.354157952307093 0.899629044151136 0.54102522163879 0.943649305642859 0.995314665488626 -0.0440729971748888 "KRAS MUT" "SB.216763_IC_50" 0.0897400032305874 0.514272513671442 0.291332290074268 0.35427704595021 0.899629044151136 0.163904377990996 0.453474227457396 0.925809648901546 0.145089753260082 "TET2 MUT" "Vinblastine_IC_50" 0.00927425932806834 0.169474685375669 -2.68260069455002 0.354277799441797 0.899629044151136 -0.70096288647176 0.134426102365861 0.828478983422079 -1.78536161390768 "IDH1 MUT" "AZD.2281_IC_50" 0.409129741963803 0.810863922870015 -0.875418690944878 0.354317676810333 0.899629044151136 -0.737199795914139 0.460023056295752 0.927882071987865 -0.693690167428686 "SMARCA4 MUT" "RO.3306_IC_50" 0.369939903080839 0.78995823016613 0.420684404761904 0.35436715453131 0.899629044151136 0.412121224810782 0.0282608671047666 0.594750617908608 1.17120090995229 "APC MUT" "Erlotinib_IC_50" 0.340790367301565 0.778503205456979 -0.503613192071084 0.35451107029182 0.899629044151136 -0.455740399396285 0.441020030445983 0.924472815010418 -0.484919871286059 "KDR MUT" "Etoposide_IC_50" 0.189451292923835 0.664501158158208 -1.85898418652849 0.35451943685726 0.899629044151136 -0.854176546831581 0.19928035639001 0.851001889249827 -1.73999631451928 "MS-HL MUT" "Gemcitabine_IC_50" 0.0969622171588544 0.531228532133119 -0.862012788656862 0.354737319709092 0.899629044151136 0.325983039089686 0.29114649048843 0.891022884087089 -0.572307200761574 "MYC MUT" "Bryostatin.1_IC_50" 0.187023112969044 0.662667705483822 0.263477509755249 0.354783610350456 0.899629044151136 0.175452110159093 0.820954805638049 0.977383317127464 0.0456862042617034 "CDK6 MUT" "Gefitinib_IC_50" 0.464255491163636 0.829490249358073 -0.399416835683757 0.354917399953196 0.899629044151136 -0.454280020364107 0.46958282915046 0.929276781658587 -0.355133899491296 "KDM5C MUT" "CHIR.99021_IC_50" 0.420342803096443 0.81490164468446 0.579929377162639 0.35503079180764 0.899629044151136 0.629797216144503 0.544601122663131 0.946853280734584 0.419429675297218 "BRAF MUT" "CGP.60474_IC_50" 0.456429136195945 0.828966839128293 -0.313465741991343 0.355068975227141 0.899629044151136 -0.316567135186638 0.412098034856817 0.921714070263062 -0.43349326006933 "HRAS MUT" "Thapsigargin_IC_50" 0.374265486455544 0.794193236181393 1.14803408741258 0.355300191442249 0.899629044151136 0.914936270991498 0.158750881655196 0.83854630828105 1.76971321158536 "NRAS MUT" "WZ.1.84_IC_50" 0.20061559781857 0.674012093366938 0.484795674458884 0.355357902984756 0.899629044151136 0.302566435495183 0.342866507470218 0.907180409180092 0.383851596222239 "HRAS MUT" "GW.441756_IC_50" 0.118770319446222 0.577025305814989 -0.778190319949007 0.355441780649145 0.899629044151136 -0.453266782656044 0.15551935333622 0.837288218996252 -0.702512839700469 "KRAS MUT" "Embelin_IC_50" 0.642502090170144 0.896094514063559 -0.0792289761024872 0.355495803546895 0.899629044151136 0.133181539280386 0.466382711889154 0.929276781658587 -0.14064558621831 "BRCA2 MUT" "Axitinib_IC_50" 0.0682665569361422 0.462100070236188 1.45466345801529 0.355552978087267 0.899629044151136 0.627325692077777 0.429613048428651 0.922428741067589 0.559535607125834 "KDR MUT" "Lenalidomide_IC_50" 0.221993275161238 0.694197984755969 0.750078865652729 0.355592417787494 0.899629044151136 0.498219687913896 0.319818703060068 0.900918773778407 0.59207115589537 "APC MUT" "Docetaxel_IC_50" 0.010192532199293 0.179247284083012 0.87062660136055 0.355613643879227 0.899629044151136 -0.248090049950661 0.967927388911445 0.997173634484198 0.0160836456450927 "ERBB2 MUT" "SB.216763_IC_50" 0.940535663955494 0.989446598697723 -0.0275715230460918 0.355657873439324 0.899629044151136 -0.338498415937853 0.463895619832489 0.929276781658587 -0.278310518719236 "BRAF MUT" "IPA.3_IC_50" 0.547164301674028 0.863426823590449 0.176143278648553 0.355938823662851 0.899845232077088 0.249504690258788 0.559646718019261 0.949294892873838 -0.189810223740583 "MLH1 MUT" "Cytarabine_IC_50" 0.921225778795843 0.986093099936007 -0.0597808001052999 0.356000815852639 0.899845232077088 -0.426270888155941 0.485183089432637 0.933639405738697 0.393902910975946 "STK11 MUT" "PF.02341066_IC_50" 0.353440347344334 0.785062892590933 0.68018827457627 0.356047308357042 0.899845232077088 0.626017215182738 0.381635463466869 0.915134825237766 0.716313597957152 "EP300 MUT" "AS601245_IC_50" 0.588258544623576 0.876506729771444 0.564423602787451 0.356263113702684 0.900134484436283 0.77302583535585 0.433661259304751 0.922569292988365 0.802446777193475 "ERBB2 MUT" "Nilotinib_IC_50" 0.474705809354349 0.834555294653764 0.288673920151653 0.356387162090411 0.900171645027838 -0.312213164503303 0.589134800539395 0.949294892873838 -0.20928289427988 "TET2 MUT" "Vorinostat_IC_50" 0.00510422175476423 0.122847136596372 -2.04471614990142 0.356584762841183 0.900171645027838 -0.522295947031944 0.229295723173793 0.868145256417768 -0.98694939707518 "ALK MUT" "PD.0325901_IC_50" 0.469589414260872 0.832012966658205 -0.940562414682528 0.356608974262472 0.900171645027838 -1.12998089265767 0.0444811296845574 0.661703371404613 -2.80937498473162 "MYCL1 MUT" "JNK.Inhibitor.VIII_IC_50" 0.453085465096504 0.828509891052426 -0.326082285714283 0.356683258512889 0.900171645027838 -0.3814158277753 0.695197686898095 0.961100601384891 -0.188751149881044 "KRAS MUT" "Metformin_IC_50" 0.390786336293141 0.801837403580487 0.145609865305692 0.357130385206635 0.900741035069657 -0.154848276497144 0.20237402348622 0.852959543285214 0.246347204807563 "CDK4 MUT" "JW.7.52.1_IC_50" 0.285324969418776 0.740302864659114 -2.03731603389831 0.357179285029949 0.900741035069657 -1.0747908821089 0.5585796148219 0.94928677421639 -1.13949273528538 "MSH2 MUT" "Erlotinib_IC_50" 0.351240189098641 0.784966682190403 0.806729963369961 0.357213143285141 0.900741035069657 0.720584256552375 0.661947828354487 0.958689538788368 0.374753750327815 "PDGFRA MUT" "RO.3306_IC_50" 0.494680370617491 0.843282996121548 0.450976817288806 0.357983830039865 0.901643975806312 0.578819151794138 0.422514864242487 0.922428741067589 0.537426423100709 "CCND1 MUT" "Salubrinal_IC_50" 0.116872834564887 0.572187234713762 0.865897192982459 0.358130267479744 0.901643975806312 0.426222086500573 0.372026576834213 0.913948248824328 0.581063439500422 "NF1 MUT" "BX.795_IC_50" 0.815018148545972 0.954309977735381 -0.081511844265439 0.358184275582128 0.901643975806312 -0.248233790970735 0.476706887022272 0.929855889225741 -0.237328973249738 "APC MUT" "Gefitinib_IC_50" 0.0387439446688844 0.356934618884194 0.619977291812409 0.358333704539106 0.901643975806312 0.26013122900868 0.0371571582960186 0.642009188379263 0.69198292210778 "MYCL1 MUT" "Sunitinib_IC_50" 0.3772146753831 0.795261485512158 0.858055208045983 0.358340176785016 0.901643975806312 0.667475850040264 0.58812251749149 0.949294892873838 -0.479728162205865 "EGFR MUT" "PF.562271_IC_50" 0.539294762118572 0.861419263046422 0.200424537372638 0.358360220804136 0.901643975806312 0.245362568065827 0.319989833115509 0.900918773778407 0.334621558650329 "BRCA2 MUT" "MG.132_IC_50" 0.121576210367686 0.580982694522287 2.59188020270269 0.358384287418316 0.901643975806312 1.36598905189784 0.141855063129288 0.831473272394224 2.31803474322084 "MSH6 MUT" "Sorafenib_IC_50" 0.785260071843501 0.946055035513406 0.253766470989759 0.358543671260627 0.901643975806312 0.813409405470962 0.714308060177871 0.962630898212352 0.348943858574963 "MS-HL MUT" "JNJ.26854165_IC_50" 0.552982819953317 0.866603215811789 0.105179554401903 0.358641732787199 0.901643975806312 0.152822582922794 0.661926643998412 0.958689538788368 -0.079530090521549 "APC MUT" "BMS.509744_IC_50" 0.972230157002611 0.995220468612913 0.0185282167832166 0.358679076694164 0.901643975806312 0.374308802437668 0.429303129597974 0.922428741067589 0.489631245434824 "MDM2 MUT" "BMS.536924_IC_50" 0.182291377853047 0.658636992153339 -1.48469308219178 0.358775109978031 0.901643975806312 -0.755114901877637 0.290093255716833 0.891022884087089 -1.11834515096755 "SETD2 MUT" "BMS.754807_IC_50" 0.98312222390863 0.996723172778267 0.0344969878260856 0.358789529388527 0.901643975806312 -1.26017545840797 0.765125264048917 0.969901216545994 0.478218121280533 "CDK4 MUT" "XMD8.85_IC_50" 0.528112446698217 0.855147571292734 0.814725102739726 0.359077224246802 0.901718190876565 1.01991707313971 0.25032770699519 0.875707386589409 1.46565982587849 "PDGFRA MUT" "PF.4708671_IC_50" 0.445185607186022 0.825606373270691 -0.403307471783295 0.359111116270904 0.901718190876565 -0.478106696733129 0.449753807549626 0.925809648901546 -0.411200185141541 "FGFR2 MUT" "Camptothecin_IC_50" 0.0665472863791344 0.458731804980223 2.91613854459202 0.359194375105707 0.901718190876565 0.929017047763892 0.956708201791104 0.996361528879345 0.107600314345649 "KIT MUT" "Roscovitine_IC_50" 0.515126016458423 0.852194122611816 -0.772128275862066 0.359544295653088 0.901718190876565 -0.992402325225631 0.79273939152549 0.975393509832241 -0.314443573956724 "TSC1 MUT" "Cytarabine_IC_50" 0.566013636779659 0.872389778906173 0.806577174573049 0.359574757280229 0.901718190876565 0.977861868131231 0.239770920807458 0.875707386589409 1.52633838002331 "CDKN2A MUT" "CEP.701_IC_50" 0.00241801053771335 0.0750851454036092 -0.486720061997873 0.359577881694585 0.901718190876565 0.111810465917205 0.310381539560092 0.89718581932126 -0.168510215963455 "EZH2 MUT" "ZM.447439_IC_50" 0.6390450560492 0.895624997957207 0.376242449019607 0.359924775651042 0.901718190876565 0.579895253993757 0.698799303918386 0.961100601384891 0.292562399680299 "APC MUT" "Cyclopamine_IC_50" 0.16923187883753 0.648365181185948 0.623539608095092 0.359931169594258 0.901718190876565 0.395164933080109 0.309301368113289 0.89718581932126 0.561576177170919 "TET2 MUT" "Rapamycin_IC_50" 0.960463941465072 0.99365707033384 0.0867757542087522 0.360022604382144 0.901718190876565 1.38957835574148 0.688729986869657 0.961100601384891 -0.866707690387747 "HRAS MUT" "EHT.1864_IC_50" 0.505400483157669 0.847679261741881 0.378754831460677 0.360091637830032 0.901718190876565 0.520073274161675 0.916902486147566 0.99244497007636 0.057662295621564 "EZH2 MUT" "JW.7.52.1_IC_50" 0.0248535260981874 0.291577497064733 3.0255159556314 0.360187635796294 0.901718190876565 0.749312411581496 0.0103170613729516 0.450367315182713 4.01785246590162 "STK11 MUT" "JNK.9L_IC_50" 0.920283831352459 0.986016435821543 -0.0286549556451619 0.360215517987638 0.901718190876565 -0.205041331134877 0.977228052878898 0.99742775226181 0.00862869361904985 "VHL MUT" "Etoposide_IC_50" 0.647051669640073 0.897186614618066 0.399200498257834 0.360229035656705 0.901718190876565 0.522338434661026 0.881316350504639 0.988301482344111 -0.133646226892923 "CDK4 MUT" "Gemcitabine_IC_50" 0.431885069025618 0.821209960265379 1.13379022715291 0.360240529358187 0.901718190876565 0.886611276443896 0.314249024629441 0.900294798053993 1.4426818709218 "CDKN2C MUT" "Gemcitabine_IC_50" 0.203376536287662 0.675665259036525 1.64335419047618 0.360550434276657 0.902056915037558 0.788553144861727 0.517379847000633 0.939635632721979 0.935261216905146 "EZH2 MUT" "CCT007093_IC_50" 0.333126745589393 0.773185226006147 0.491588677130052 0.360578994300566 0.902056915037558 0.462273779966424 0.275809777216762 0.883780956691668 0.559426945504722 "CCND3 MUT" "GDC0941_IC_50" 0.858872634110316 0.96613652483011 -0.22882418069815 0.361101064346016 0.902094663219241 -0.944871183363666 0.946441388796975 0.995668765770473 -0.0853975870811529 "FLT3 MUT" "NSC.87877_IC_50" 0.405518685327306 0.807916494806729 0.467055882352942 0.361230047287316 0.902094663219241 0.509270396782075 0.582711912181562 0.949294892873838 0.315217968411347 "SMARCA4 MUT" "Metformin_IC_50" 0.655269850105562 0.901148229801177 -0.205252625482626 0.361320852464928 0.902094663219241 -0.389043073159624 0.323668649289834 0.900918773778407 -0.507402396566696 "MLL_AFF1 MUT" "Gemcitabine_IC_50" 0.0125238990818198 0.201494108234857 -7.14894050782616 0.361405824589482 0.902094663219241 -1.7828436119409 0.0604496532026143 0.702533085254831 -5.07180370397235 "CDKN2A MUT" "Pazopanib_IC_50" 0.0658188440035286 0.457742485196035 -0.29121700006134 0.36141111649583 0.902094663219241 0.129522828216084 0.69968512252365 0.961100601384891 0.0639235587696031 "CTNNB1 MUT" "Bexarotene_IC_50" 0.996539488206314 0.998977896287767 -0.00182255219454359 0.361529153059393 0.902094663219241 0.341055941332245 0.668240490572212 0.959230524020512 0.193234805861374 "TP53 MUT" "WZ.1.84_IC_50" 0.483100901304656 0.839032590911741 -0.14239851241311 0.361612479839304 0.902094663219241 -0.165890603929983 0.205893331141614 0.853446327418758 -0.268449483586609 "CCND1 MUT" "ABT.263_IC_50" 0.0528703038856356 0.410797173060656 0.862064415950923 0.361715884034459 0.902094663219241 0.367945666261032 0.619551615618462 0.950496524771391 0.207701993001257 "PIK3R1 MUT" "GSK.650394_IC_50" 0.0291686598195898 0.316210068663154 1.61283337521969 0.361838927023944 0.902094663219241 0.436418202525175 0.0477190794008462 0.675422090187856 1.45161696525889 "APC MUT" "Midostaurin_IC_50" 0.137072679292999 0.604353219297467 0.504704562045458 0.36185393111333 0.902094663219241 0.250870752206476 0.647893686069374 0.957449344088104 0.172246203379527 "FAM123B MUT" "SB590885_IC_50" 0.491723877793251 0.842990705166559 -0.886469868421031 0.361854050092703 0.902094663219241 -0.980339940768792 0.319983513457592 0.900918773778407 -1.11913255451804 "CDKN2A MUT" "X17.AAG_IC_50" 0.000360485540852538 0.0243057637373541 -0.680544765168445 0.36186183933614 0.902094663219241 -0.160776223002986 0.923586773820839 0.993978204254811 0.0184312187720028 "CDK4 MUT" "BI.D1870_IC_50" 0.73735561089981 0.929386202157424 0.172301106382979 0.361914568747906 0.902094663219241 -0.404958241221824 0.881675344201537 0.988301482344111 0.0760205734004506 "ALK MUT" "AUY922_IC_50" 0.633596077987297 0.89399270048764 -0.639287194782612 0.36240603163189 0.902578798567615 -0.819281885879118 0.246851628009206 0.875707386589409 -2.08931242735795 "FLCN MUT" "Axitinib_IC_50" 0.269443764789417 0.732006752858616 0.985138337142862 0.362485667291016 0.902578798567615 0.685606076686794 0.595031038358551 0.949294892873838 0.587409970547755 "PDGFRA MUT" "ABT.263_IC_50" 0.301318273267534 0.751119785777076 1.01005505108055 0.362703750656614 0.902578798567615 0.801229101424468 0.676200662886171 0.960256725054738 0.359829388282416 "MYCN MUT" "AZD6244_IC_50" 0.228562065804624 0.700676460618178 0.601330519108932 0.362799631615116 0.902578798567615 0.428927943348339 0.294052808636482 0.894167310052 -0.569196533009658 "MDM2 MUT" "Midostaurin_IC_50" 0.968402132273506 0.994723494878673 -0.0236098723776226 0.362821471767015 0.902578798567615 -0.418179773099448 0.680415876994331 0.961100601384891 0.222442982963281 "SMAD4 MUT" "PD.0325901_IC_50" 0.231602718706328 0.704757001699372 -0.550891862987554 0.362841571079013 0.902578798567615 -0.404584608903016 0.929004090941815 0.99422596912377 -0.038185492348186 "CDKN2A MUT" "QS11_IC_50" 0.256217002779856 0.720311238267775 -0.187238025395656 0.362862352281228 0.902578798567615 0.115948561935834 0.573430530086394 0.949294892873838 -0.103762060941323 "EWS_FLI1 MUT" "CHIR.99021_IC_50" 0.176125079132211 0.654424263714207 0.507337654320982 0.362934117929262 0.902578798567615 0.34429604172866 0.192910786718186 0.851001889249827 0.537523791278957 "CCND1 MUT" "PD.0332991_IC_50" 0.470037816268226 0.832012966658205 0.29230568891775 0.36302347353716 0.902578798567615 -0.296153635648918 0.589441178235588 0.949294892873838 -0.221152335109462 "MDM2 MUT" "WH.4.023_IC_50" 0.926225573740691 0.98643792569589 0.148310701030929 0.363273310601952 0.902790815055352 1.26585213309456 0.726112625468258 0.965402608571648 0.524395282600455 "GNAS MUT" "NSC.87877_IC_50" 0.55115654251177 0.865580796066258 -0.212800489510489 0.363312056413448 0.902790815055352 -0.318881334715969 0.650694175312999 0.957867556929346 -0.165333147975048 "BRAF MUT" "AG.014699_IC_50" 0.417582589980179 0.814099702076568 0.170460496919036 0.363442534968122 0.902862420434095 -0.186675286669799 0.786855337716697 0.975087420732438 0.0620701257049073 "STK11 MUT" "AG.014699_IC_50" 0.669720696499715 0.906882709825482 -0.12623165248227 0.36372094868854 0.903138001147444 -0.235859288201181 0.268508494741385 0.877667994772999 -0.32196791280337 "ERBB2 MUT" "WO2009093972_IC_50" 0.589239824332306 0.876506729771444 0.21866926682502 0.364051655430639 0.903138001147444 0.34089948716516 0.763671268315816 0.969901216545994 -0.127994786335374 "MSH2 MUT" "GSK.650394_IC_50" 0.528161597441489 0.855147571292734 -0.499153497243114 0.36411953412719 0.903138001147444 0.467209872635431 0.641612292802491 0.955105392621341 -0.370220554994852 "FGFR2 MUT" "RO.3306_IC_50" 0.168631460528216 0.647707839347554 1.43222273437499 0.364225317037369 0.903138001147444 0.908125326645436 0.440231516125643 0.924472815010418 1.13229147280231 "EZH2 MUT" "AZD.0530_IC_50" 0.568644353820026 0.872389778906173 0.580053800000001 0.364341350876557 0.903138001147444 -0.798960390702018 0.855631445871981 0.984631915507353 0.199887300280693 "AKT2 MUT" "CCT007093_IC_50" 0.466729841952058 0.830828665219814 0.331092808988765 0.36436334191933 0.903138001147444 0.411568094589983 0.313724062420216 0.900294798053993 0.466571440979737 "SETD2 MUT" "PLX4720_IC_50" 0.661031254359978 0.902400992643984 -0.587182814531551 0.364620266867253 0.903138001147444 -1.08212415391813 0.479813311401628 0.930304161706959 -0.857937475690102 "AKT2 MUT" "MS.275_IC_50" 0.454396181057652 0.828966839128293 1.16384671331059 0.364734566235143 0.903138001147444 1.15979449111883 0.5830371354067 0.949294892873838 0.891250850827148 "MS-HL MUT" "AZD8055_IC_50" 0.124503157524942 0.585102471530182 -0.299476876398209 0.365001975046788 0.903138001147444 -0.137876416201918 0.323242717445518 0.900918773778407 -0.203925787955165 "FLCN MUT" "AZD.2281_IC_50" 0.36402569438977 0.787306955898826 0.78675898422091 0.365036157952819 0.903138001147444 0.592384069520699 0.407473206598226 0.919870246008857 1.08668707640941 "RB1 MUT" "AZ628_IC_50" 0.00695925603483897 0.145995124935243 1.16109413791305 0.365092761629307 0.903138001147444 0.299900080616349 0.57271358449447 0.949294892873838 0.249115307284416 "NRAS MUT" "Embelin_IC_50" 0.0944805121067642 0.526778332037195 -0.383168838451266 0.365183650877018 0.903138001147444 -0.170664177532438 0.719572263716161 0.964898274809486 -0.0931343863229673 "VHL MUT" "JNK.Inhibitor.VIII_IC_50" 0.360922682655084 0.786783098836476 0.371731242774564 0.365225592899293 0.903138001147444 0.354042107475103 0.523667769202806 0.940554660491705 0.283410610344217 "CTNNB1 MUT" "Methotrexate_IC_50" 0.568854872499952 0.872389778906173 0.384770141929501 0.36536920753777 0.903138001147444 0.465922921011234 0.741966088730059 0.96672489654949 0.185174816625701 "MLH1 MUT" "Temsirolimus_IC_50" 0.675424225304322 0.908552538148308 0.290940833976833 0.36547125714634 0.903138001147444 0.485317655455818 0.233804813011831 0.869962136993019 0.791482243504027 "CCND2 MUT" "TW.37_IC_50" 0.375649057843776 0.795051761241315 0.84685723318385 0.365758111364454 0.903138001147444 0.778021089250748 0.802404664106509 0.976365695720597 0.229386338101992 "PIK3CA MUT" "Rapamycin_IC_50" 0.509320110521047 0.849059439813668 -0.564301745644601 0.365933372418064 0.903138001147444 -0.661402626219107 0.540542711500165 0.944806105261359 -0.5808659223466 "CDKN2A MUT" "MK.2206_IC_50" 0.359334879410079 0.786601117838604 -0.149014372776529 0.365965617678297 0.903138001147444 0.122537570162295 0.449709631980791 0.925809648901546 -0.136816758077379 "FLT3 MUT" "Pyrimethamine_IC_50" 0.0592997028895749 0.439862785571841 -2.53678965986397 0.365981307885015 0.903138001147444 -1.04209935956488 0.281803063373879 0.887872038823822 -1.46381521167233 "FGFR3 MUT" "GNF.2_IC_50" 0.904515357343268 0.980351585131262 0.106709615646259 0.36608474498499 0.903138001147444 0.763469121141995 0.861571001396196 0.985524480087535 0.157996227275546 "ERBB2 MUT" "Metformin_IC_50" 0.662887174372838 0.903526384925934 0.154761102797283 0.366086638646996 0.903138001147444 0.30922787251122 0.981394422935064 0.997957874252292 0.00866041991452016 "SMAD4 MUT" "AZD7762_IC_50" 0.588906977563138 0.876506729771444 0.190820973925925 0.36609792916318 0.903138001147444 -0.256911742265087 0.498445584884165 0.934042323734638 -0.231050652613695 "MYCL1 MUT" "Docetaxel_IC_50" 0.741105239519377 0.929570057037101 -0.212762796875001 0.366301668560064 0.903138001147444 -0.435704146079111 0.798917761227917 0.976360691959787 -0.173299069964154 "CDKN2C MUT" "CGP.082996_IC_50" 0.490667098810465 0.84270247622041 -0.46482371264368 0.36632104110539 0.903138001147444 -0.513328350312972 0.252096134266908 0.875707386589409 -0.926923616916719 "MYC MUT" "Sunitinib_IC_50" 0.915926581560537 0.984784694977867 -0.0529942144607844 0.366517651618389 0.903138001147444 -0.342307691210752 0.162942214079338 0.839927262232576 -0.648528732184801 "MDM2 MUT" "VX.680_IC_50" 0.676340046510211 0.90871043162741 0.494982642611686 0.366587256960391 0.903138001147444 0.695327876585726 0.809738780524064 0.977383317127464 0.295097316636904 "CCND2 MUT" "Doxorubicin_IC_50" 0.415187577128289 0.814099702076568 0.919473229384428 0.366599651935605 0.903138001147444 0.631273625121344 0.582135194196525 0.949294892873838 0.722255147500508 "CDK4 MUT" "AICAR_IC_50" 0.788768380525079 0.946884544892927 0.154497581699347 0.36665158062142 0.903138001147444 -0.465603779152061 0.919664522029986 0.993794649720217 -0.0588337439961447 "MSH2 MUT" "Gefitinib_IC_50" 0.0937709744717488 0.524345774352707 -1.03395246113848 0.36687968812063 0.903138001147444 -0.499604854768293 0.243280220903372 0.875707386589409 -0.653584133602001 "CDK4 MUT" "BI.2536_IC_50" 0.875811400802003 0.971594429690931 0.251484650847458 0.366923120785732 0.903138001147444 0.869423277827045 0.711778566529694 0.962630898212352 0.619550032641251 "PDGFRA MUT" "BX.795_IC_50" 0.180685326383555 0.658636992153339 -0.960380068431781 0.36696424145159 0.903138001147444 -0.498886462246568 0.443285183659526 0.925809648901546 -0.49248777101679 "BRCA1 MUT" "JNJ.26854165_IC_50" 0.219013229054101 0.692453909775927 0.702675495495504 0.367175568470595 0.903138001147444 0.482613274026778 0.20503425937462 0.853446327418758 0.682793978620875 "MYCN MUT" "PF.4708671_IC_50" 0.778846800854131 0.942619029488353 0.0840012731481481 0.3672504139473 0.903138001147444 -0.281757696122297 0.928784175986616 0.994186152404781 0.0341296255196601 "MET MUT" "CI.1040_IC_50" 0.0898717420581104 0.514272513671442 0.88447720298314 0.367258657970694 0.903138001147444 0.421745133695306 0.025986705489466 0.582797806696838 1.02142532628179 "NF1 MUT" "BMS.509744_IC_50" 0.22919450137579 0.701404674954649 0.613067701754387 0.367361466220621 0.903138001147444 0.344273704670606 0.505946044262111 0.935912793170426 0.384955444746268 "APC MUT" "MS.275_IC_50" 0.430391888791867 0.820918238409269 -0.531271156530084 0.367365192206723 0.903138001147444 -0.52194275996044 0.592430092720926 0.949294892873838 -0.454933478216944 "NF2 MUT" "CGP.60474_IC_50" 0.117314359156705 0.572770106470973 -0.935210027972023 0.367518395806151 0.903138001147444 -0.413259975956055 0.641114921971871 0.955103296458244 -0.297610682246726 "CDKN2C MUT" "Epothilone.B_IC_50" 0.200781428355629 0.674012093366938 0.95194579188712 0.367577147335157 0.903138001147444 0.381047166093716 0.646797585353673 0.957449344088104 0.397179827398468 "CDH1 MUT" "ZM.447439_IC_50" 0.0755277559491616 0.480779116570693 1.01060627272726 0.367611265244823 0.903138001147444 0.412958991133711 0.246957905535771 0.875707386589409 0.669169089751002 "APC MUT" "Thapsigargin_IC_50" 0.593012697705676 0.878261059495448 0.283935895840715 0.36772035952591 0.903138001147444 0.380574784279501 0.942797222648366 0.995314665488626 0.0451014173278085 "FGFR3 MUT" "Salubrinal_IC_50" 0.807585170626197 0.952641225877339 -0.297200170648466 0.36772289293426 0.903138001147444 0.902404313497358 0.808616622260206 0.977383317127464 -0.294386752954171 "MSH2 MUT" "A.443654_IC_50" 0.313275232502156 0.759215564942334 0.921595580756019 0.367896365425613 0.903314244220313 0.53683017235464 0.376843962702223 0.914419412871569 0.836698083835697 "AKT2 MUT" "PF.4708671_IC_50" 0.32343302759956 0.765322958956319 -0.47660267722474 0.368195043001727 0.903797727169248 -0.42817370788326 0.559744052786744 0.949294892873838 -0.288444265652876 "FGFR2 MUT" "VX.702_IC_50" 0.480113249508689 0.836384026851052 0.749485477099255 0.368536151503591 0.90412827536647 0.786637531014332 0.534856071511288 0.943443271455699 0.864320094689113 "SMAD4 MUT" "RO.3306_IC_50" 0.518242379684056 0.852380843541241 -0.191089183480455 0.368609922599933 0.90412827536647 -0.260944763749156 0.222798361262127 0.865601665610206 -0.383610586925775 "NF1 MUT" "SB590885_IC_50" 0.268183911343625 0.731493033366932 0.449108321303257 0.368647170218217 0.90412827536647 0.307575970540908 0.365024365220011 0.913900497593792 0.350035822186984 "PTEN MUT" "LFM.A13_IC_50" 0.561835054241006 0.870491471862243 -0.0753523959827833 0.368736923024136 0.90412827536647 -0.112808630636353 0.913315728648553 0.99082410867764 0.0152454926748649 "MSH6 MUT" "Tipifarnib_IC_50" 0.263391159558563 0.725551143932877 -0.890943603251322 0.369017604170921 0.904394528838164 -0.475241556400789 0.309689846784707 0.89718581932126 -0.791496761630578 "SMARCA4 MUT" "Bexarotene_IC_50" 0.417059595412682 0.814099702076568 -0.396706519595247 0.369049180555062 0.904394528838164 -0.389324278003627 0.613320560035627 0.949930222127033 -0.265227400719707 "VHL MUT" "CI.1040_IC_50" 0.412185004940616 0.812480994891775 0.522280360038615 0.369301015704296 0.90476201943996 0.5145254467002 0.555516900682821 0.948071221654821 0.359009554860529 "CCND2 MUT" "CCT007093_IC_50" 0.477253457659033 0.835993679974334 0.509508482142856 0.36956048310788 0.904973687116429 0.640101817935632 0.308274434201996 0.89718581932126 0.739277544311669 "MYCN MUT" "Paclitaxel_IC_50" 0.025626635682318 0.297892868448515 1.31028160351967 0.369592202991223 0.904973687116429 0.238201794492583 0.814812023550337 0.977383317127464 -0.166273108670345 "CCND1 MUT" "CI.1040_IC_50" 0.223883918659868 0.696139064632428 0.445392528942117 0.369693113034388 0.904973687116429 0.296479275544662 0.336908207462771 0.905430766021494 0.334674285310813 "KDM5C MUT" "Paclitaxel_IC_50" 0.177453304914522 0.656513564381252 -1.76548669283277 0.36985380506016 0.905117564822066 -0.512610248660089 0.261700751786985 0.877052916121269 -1.46252404022911 "KIT MUT" "LFM.A13_IC_50" 0.633871837549926 0.89399270048764 0.236579300699302 0.370307267053603 0.905775473796383 0.419800337705455 0.390973710022444 0.915926348152589 0.424998363753647 "NOTCH1 MUT" "NVP.TAE684_IC_50" 0.882943391031966 0.973927829424842 0.111043898710286 0.370326623730961 0.905775473796383 0.578674029074399 0.702945740389842 0.962139809888331 -0.332612856358892 "AKT2 MUT" "VX.702_IC_50" 0.875139965722975 0.971594429690931 -0.0966838012820511 0.370476801309075 0.905893301879377 -0.449395753263764 0.385582466892291 0.915331032347709 -0.500280363212764 "NF2 MUT" "NVP.TAE684_IC_50" 0.0571151445116511 0.429883025426179 -1.49766457241381 0.370798603271964 0.906383020792582 -0.590675546180763 0.334012667348657 0.903569160603576 -0.837429281014242 "BRCA1 MUT" "Methotrexate_IC_50" 0.092422322137242 0.520483603614995 1.86890439637827 0.37104039665234 0.906383020792582 0.754140669273744 0.0922876604537282 0.76758746139711 1.47571066685276 "RB1 MUT" "Axitinib_IC_50" 0.287166334891134 0.742393685445311 0.263259276520974 0.371273307492474 0.906383020792582 0.191691626107612 0.400565113464856 0.916589616820582 0.202056990237693 "FGFR3 MUT" "PAC.1_IC_50" 0.186718070804677 0.662394203631185 -1.31826368060394 0.371365374953339 0.906383020792582 -0.747124116540722 0.153694951257726 0.835611501078903 -1.3690680957139 "SMARCA4 MUT" "Bicalutamide_IC_50" 0.602965139768701 0.880745626033854 0.0982157532926446 0.371383267223501 0.906383020792582 0.159783388410413 0.84211231890731 0.982408776002613 0.0396153903492032 "CDKN2A MUT" "Temsirolimus_IC_50" 0.0037966724893596 0.101560989090369 -0.573844529400759 0.37142513056092 0.906383020792582 -0.141514351252126 0.25109175630612 0.875707386589409 -0.246382762784577 "FAM123B MUT" "LFM.A13_IC_50" 0.352254231794483 0.784969887597353 0.461932097902105 0.371501477524232 0.906383020792582 0.417207923668772 0.42426145714251 0.922428741067589 0.400556579952453 "FBXW7 MUT" "BMS.754807_IC_50" 0.641191785225157 0.896094514063559 0.233206440294838 0.371504733451654 0.906383020792582 0.374623351928101 0.325369750007451 0.900918773778407 0.501953280155466 "CDKN2a(p14) MUT" "Methotrexate_IC_50" 0.994497957466425 0.998977896287767 -0.00140393861245966 0.371595606204909 0.906383020792582 -0.143838964508335 0.267865459432781 0.877052916121269 -0.198592044124199 "APC MUT" "CCT018159_IC_50" 0.0138358015977855 0.212607581866345 0.689279266433499 0.37183054352414 0.906707044766031 0.245287035484696 0.0597963064863009 0.70215997387469 0.640107119372664 "TET2 MUT" "XMD8.85_IC_50" 0.188987646608893 0.663923769593977 -1.3858586597938 0.372214952779974 0.907326077932377 -0.815714922847332 0.365991758912903 0.913948248824328 -1.14398701657055 "PTEN MUT" "CGP.082996_IC_50" 0.951907992504584 0.992474158421367 0.0155564784946239 0.372288731897938 0.907326077932377 0.196687817869218 0.5720988789967 0.949294892873838 0.155593116985718 "CDKN2a(p14) MUT" "Bortezomib_IC_50" 0.000824914133133524 0.0396003373857234 -0.93398763848721 0.372978079639909 0.907735708984487 -0.219875619874129 0.48402814361622 0.932745808137526 -0.213562935212614 "SMARCA4 MUT" "Etoposide_IC_50" 0.99047892768199 0.998036562927507 -0.00932298251748314 0.373006673662866 0.907735708984487 -0.450156865126554 0.520486429133479 0.939635632721979 -0.54361548966458 "HRAS MUT" "OSI.906_IC_50" 0.610670362835236 0.884818029552257 -0.466059737762234 0.373110822673563 0.907735708984487 -0.77225268582269 0.459639535395759 0.927740616784032 -0.680342176508199 "MLH1 MUT" "PF.02341066_IC_50" 0.251191546992121 0.717470497840808 0.66810031164384 0.373168394397627 0.907735708984487 0.484386505725491 0.0565972484259163 0.697813103075383 1.10191815643729 "MLL_AFF1 MUT" "Mitomycin.C_IC_50" 0.147122716223624 0.619919550890177 -2.2735776330435 0.373241534186445 0.907735708984487 1.11150761646162 0.634599285477381 0.952678811939519 -0.729900292000607 "CDK6 MUT" "X681640_IC_50" 0.148644011969113 0.623280203162274 0.79161292592592 0.373384543599399 0.907735708984487 0.416908881020751 0.242516248771962 0.875707386589409 0.60061557973706 "MLL_AFF1 MUT" "ZM.447439_IC_50" 0.0221305483603231 0.271944247685126 -2.58430115429684 0.373450424202438 0.907735708984487 -0.81371361623635 0.241609682369861 0.875707386589409 -1.2672944495921 "JAK2 MUT" "SB590885_IC_50" 0.180251865693692 0.658614416960816 1.00082806462587 0.373497955448193 0.907735708984487 0.55553820799432 0.580304272431476 0.949294892873838 0.398989608896891 "EZH2 MUT" "PD.0325901_IC_50" 0.475859607241174 0.835134084317001 0.80389961332009 0.373538607379957 0.907735708984487 0.937969878313465 0.3086915063379 0.89718581932126 1.00217316000329 "TET2 MUT" "Shikonin_IC_50" 0.468153338388445 0.831367686108334 -0.858858974093243 0.373683369845446 0.907735708984487 -0.897243504089816 0.741565158261478 0.96672489654949 -0.466878141485988 "EGFR MUT" "Bosutinib_IC_50" 0.571405949660468 0.872389778906173 -0.221511142034203 0.373972817587746 0.907735708984487 -0.286481748494177 0.234499133226817 0.869962136993019 -0.451325331712725 "AKT2 MUT" "ZM.447439_IC_50" 0.92877851395652 0.986689293492114 0.0641989960707269 0.37409919777743 0.907735708984487 -0.507209017761803 0.786257985790839 0.974870348210561 -0.185716023036348 "FAM123B MUT" "GDC0941_IC_50" 0.930904267422983 0.986689293492114 -0.0912028209876513 0.37418545411038 0.907735708984487 -0.751612627112619 0.510368481114262 0.938422873866617 -0.692312542732817 "MYCN MUT" "Axitinib_IC_50" 0.136807876689466 0.604353219297467 -0.617554695872029 0.374231750805598 0.907735708984487 -0.3216623702407 0.193940097565101 0.851001889249827 -0.555587780293496 "PIK3CA MUT" "JNK.9L_IC_50" 0.984602228891311 0.996723172778267 -0.00378725357744104 0.374233641297859 0.907735708984487 0.137179061874186 0.675586900899695 0.960256725054738 0.0894006906882693 "MS-HL MUT" "NVP.TAE684_IC_50" 0.259968649725069 0.723189643810247 0.474271730621871 0.374277495733682 0.907735708984487 0.308283508060222 0.262215344236164 0.877052916121269 0.534003564467865 "CDK6 MUT" "AZD.2281_IC_50" 0.860601408532003 0.966384100200122 0.0884360711909513 0.374429624748431 0.907735708984487 -0.337197321090038 0.435779105936225 0.922569292988365 -0.344421330425575 "IDH1 MUT" "Elesclomol_IC_50" 0.190562987212852 0.665314717814769 -2.01821355028462 0.374661306975939 0.907735708984487 -1.13048493043417 0.571065697264782 0.949294892873838 -0.830964056832702 "FGFR3 MUT" "Sunitinib_IC_50" 0.137180764322163 0.604353219297467 -2.48153157482994 0.374764169363482 0.907735708984487 -1.09012788072609 0.0992464060110379 0.774133667469059 -2.40862934540948 "FLT3 MUT" "Dasatinib_IC_50" 0.363818878320376 0.787306955898826 -2.05902210466437 0.374799084778334 0.907735708984487 -1.67072878696227 0.240571732040098 0.875707386589409 -2.33009946898723 "FGFR3 MUT" "VX.680_IC_50" 0.534432631986566 0.858591932827911 -1.15852643197279 0.374820128396634 0.907735708984487 1.07390338033956 0.591382423653183 0.949294892873838 -1.03571978012488 "APC MUT" "Cisplatin_IC_50" 9.2169626138508e-05 0.00899514779929769 1.19162331020858 0.374885433813861 0.907735708984487 0.24814215141987 0.195839627228518 0.851001889249827 0.46697686269824 "EGFR MUT" "Embelin_IC_50" 0.615977012249342 0.885815598771911 -0.15278568749019 0.374887707528065 0.907735708984487 -0.21648250362109 0.753041729999072 0.968780465757047 -0.0997066657732368 "KDR MUT" "AZD6482_IC_50" 0.109900807691005 0.558369034956416 -1.8175862642487 0.375171857052532 0.907735708984487 -0.851377834869591 0.265364368678231 0.877052916121269 -1.25002993479265 "CDKN2a(p14) MUT" "ZM.447439_IC_50" 0.0111555906808618 0.187804952756533 -0.366818677721019 0.375277684355764 0.907735708984487 -0.106342785880329 0.0534938378749768 0.696596443061099 -0.295142282000626 "CCND3 MUT" "BIRB.0796_IC_50" 0.276654813421199 0.735108059249974 0.93662885714288 0.375364244856837 0.907735708984487 0.729562093332787 0.311617782265479 0.898149383211927 0.857302981938246 "KDM6A MUT" "ATRA_IC_50" 0.428567982417517 0.820918238409269 -0.357634719504239 0.375983902078474 0.907735708984487 0.31687477652871 0.334120158025239 0.903569160603576 -0.396404356827779 "EWS_FLI1 MUT" "Bryostatin.1_IC_50" 0.478328848578136 0.836304203722611 0.233787832384344 0.376071029635722 0.907735708984487 -0.29510118022597 0.420466145759824 0.922428741067589 -0.289883812943672 "SMARCB1 MUT" "Pazopanib_IC_50" 0.258197063848322 0.722902939482013 -1.50823022086958 0.376083389459159 0.907735708984487 -1.00139290733662 0.203001970005791 0.852959543285214 -1.57007568042544 "KDM5C MUT" "VX.702_IC_50" 0.737304846411742 0.929386202157424 0.356089675572521 0.376148182632272 0.907735708984487 0.772332245832941 0.520230180725992 0.939635632721979 0.629694616534361 "SOCS1 MUT" "CI.1040_IC_50" 0.105082043612534 0.548638230054621 -2.05063139503824 0.376213066063088 0.907735708984487 -1.00156579261993 0.0127792683582576 0.4776467991872 -2.76833983099147 "MYCL1 MUT" "AZD7762_IC_50" 0.280821743459784 0.737978092452245 0.686376265414254 0.376237421265929 0.907735708984487 0.439416150358523 0.71517514391419 0.962635715838424 0.231723460321972 "VHL MUT" "AUY922_IC_50" 0.989347418452547 0.998036562927507 -0.00900109314587039 0.376388717528381 0.907735708984487 0.403386034636585 0.763942417417885 0.969901216545994 0.209660879777936 "MS-HL MUT" "GDC.0449_IC_50" 0.082158064254276 0.497724838837149 -0.287024301310044 0.376399344742728 0.907735708984487 -0.130518140135366 0.207974653777957 0.853446327418758 -0.225382408697306 "PIK3CA MUT" "AZD6482_IC_50" 0.0843946207851869 0.5016791346675 -0.48420171359428 0.376506443348767 0.907735708984487 -0.211647633281615 0.0741308207910732 0.741621865836141 -0.536982040093784 "MLL_AFF1 MUT" "Salubrinal_IC_50" 0.0648820782826471 0.456953003353045 -2.24636484641641 0.376557039624327 0.907735708984487 -0.906285507044734 0.116960809092933 0.803347985734216 -1.90389857933484 "FLCN MUT" "MK.2206_IC_50" 0.91689560573091 0.984975746996111 -0.0935353478260872 0.376600516026716 0.907735708984487 -0.631844706354923 0.946890475579396 0.995668765770473 -0.0820630661288527 "FLT3 MUT" "Metformin_IC_50" 0.152464925362148 0.625830613280407 -1.19195104761905 0.376723476219118 0.907735708984487 -0.693855514943089 0.618301724498805 0.950394619652337 -0.409105684725185 "BRCA1 MUT" "Gefitinib_IC_50" 0.964232014495091 0.994434372972651 0.0365445876190481 0.376740515820554 0.907735708984487 -0.653551844089696 0.718897058352302 0.964721180904622 -0.263281788483475 "MS-HL MUT" "PF.4708671_IC_50" 0.298181417697667 0.74912282052984 -0.190149702574084 0.376905986624976 0.907735708984487 -0.159945913194327 0.408405092843892 0.920903133902018 -0.166248178593084 "GNAS MUT" "FTI.277_IC_50" 0.315965676155237 0.761258739353268 0.352317632867133 0.376967009545546 0.907735708984487 0.28263473971672 0.463525331705451 0.929276781658587 0.246394796096212 "TSC1 MUT" "BIBW2992_IC_50" 0.747472759192885 0.931822792587313 0.432595037950661 0.376992184449774 0.907735708984487 1.13929944572346 0.587148058627118 0.949294892873838 0.672829828311347 "GNAS MUT" "Bosutinib_IC_50" 0.0880775412175755 0.511142337432447 1.16478986730769 0.377017802943891 0.907735708984487 0.495690392103848 0.125593309497079 0.817150972850516 0.969080704516693 "KDM5C MUT" "SB590885_IC_50" 0.538078493491346 0.860998762866154 -0.648853242055428 0.377049319211918 0.907735708984487 -0.777226079481139 0.435247398495892 0.922569292988365 -0.714077254091245 "CDH1 MUT" "Bryostatin.1_IC_50" 0.27760108291747 0.735493799937367 0.459610617762133 0.377242745982727 0.907735708984487 0.357642916993085 0.172542060171409 0.842832361237713 0.590530432005329 "BRCA2 MUT" "Bosutinib_IC_50" 0.119192512815295 0.577057450057752 1.256923545977 0.377249532318424 0.907735708984487 0.589287898520357 0.238900702671987 0.875707386589409 0.888007155206026 "MLL_AFF1 MUT" "Obatoclax.Mesylate_IC_50" 0.599611797968214 0.880481543941089 -0.856341753043487 0.377260725353197 0.907735708984487 1.07179659626677 0.792106886209186 0.975393509832241 0.415178678690603 "KDM6A MUT" "Shikonin_IC_50" 0.481603895979664 0.838487394666809 0.319896900942198 0.377864377120454 0.908143614825178 0.338828350921428 0.428450409096813 0.922428741067589 0.371871905970067 "GNAS MUT" "Vinorelbine_IC_50" 0.142435389200507 0.614659228129109 0.946498096153846 0.37792686838755 0.908143614825178 0.417394017931791 0.235036627943848 0.869962136993019 0.759010753897386 "MDM2 MUT" "SB.216763_IC_50" 0.752504626586304 0.933649480870792 -0.146542415841585 0.378030027893297 0.908143614825178 -0.39559474569002 0.575087284574613 0.949294892873838 -0.250030359687133 "PTEN MUT" "PF.02341066_IC_50" 0.80911722540819 0.952641225877339 0.0618746666666663 0.378170739656916 0.908143614825178 0.211756926649519 0.488163187941689 0.933639405738697 0.187928796895999 "MYCL1 MUT" "Cytarabine_IC_50" 0.973320464419925 0.995472410100622 0.0236389726487526 0.378201599933679 0.908143614825178 -0.471024160237404 0.400089686002638 0.916480913435499 -0.603056007665853 "SMARCA4 MUT" "CCT007093_IC_50" 0.376735783195362 0.795102302889261 0.285907500000001 0.378574436859245 0.908143614825178 0.283264821466912 0.541932389834636 0.945765861891114 0.228326959037657 "MAP2K4 MUT" "Cytarabine_IC_50" 0.965194457705279 0.994434372972651 0.0252803678272082 0.378942278137794 0.908143614825178 -0.386410624877382 0.427171508407907 0.922428741067589 -0.471257839047515 "NOTCH1 MUT" "Dasatinib_IC_50" 0.26768043592973 0.731489745211169 1.33030771610844 0.37896392717856 0.908143614825178 0.909577161254459 0.889620412062763 0.988301482344111 0.167402867481632 "CDKN2A MUT" "MS.275_IC_50" 0.532183632804455 0.857771840823296 -0.166581888721804 0.378989815003664 0.908143614825178 0.206187079571316 0.545268576487392 0.946853280734584 -0.194232616490586 "MYC MUT" "Gemcitabine_IC_50" 0.75430123380555 0.933900277236682 -0.201061084661616 0.378991899699154 0.908143614825178 -0.381187128221224 0.256250485247003 0.875707386589409 -0.72176659509323 "AKT2 MUT" "PD.0325901_IC_50" 0.413960180579273 0.813358487549673 0.824634197211146 0.379024439913974 0.908143614825178 0.831961377457246 0.615304657491146 0.950126768674963 0.448196957547364 "SOCS1 MUT" "Vorinostat_IC_50" 0.207869497257349 0.681213655034139 -1.12862438582675 0.379140758678086 0.908143614825178 -0.602659414097427 0.358340951297773 0.91161229252998 -0.749502777434674 "KDM6A MUT" "Docetaxel_IC_50" 0.785776499359741 0.946106438559363 -0.12474663095238 0.379174592349301 0.908143614825178 0.305840715364679 0.239891737431226 0.875707386589409 -0.53728539881423 "KDM5C MUT" "PF.02341066_IC_50" 0.440742048916319 0.824500931653809 0.630883584459466 0.37920565905956 0.908143614825178 0.668256582359981 0.430103277081901 0.922428741067589 0.630744617939465 "JAK2 MUT" "Doxorubicin_IC_50" 0.134846657249361 0.601893367640051 1.10774189197997 0.379222366286023 0.908143614825178 0.405263527574351 0.240766649215128 0.875707386589409 0.899979514256054 "MYCN MUT" "BX.795_IC_50" 0.228245889460789 0.700674643726675 -0.428911988370926 0.379328008919041 0.908143614825178 -0.250859289984943 0.447647592640047 0.925809648901546 -0.295555442253701 "PIK3CA MUT" "Shikonin_IC_50" 0.282690136305084 0.739072441127871 -0.313822858164984 0.379676775213065 0.908143614825178 -0.218202346051945 0.310340773811802 0.89718581932126 -0.317352549589024 "MLL_AFF1 MUT" "Z.LLNle.CHO_IC_50" 0.544345204205626 0.862633715268747 -0.780693561224492 0.379913915284811 0.908143614825178 -1.06223637951909 0.768298696336811 0.969901216545994 -0.371097791380971 "CCND1 MUT" "Epothilone.B_IC_50" 0.983930413800101 0.996723172778267 0.00926748040404076 0.380004757849799 0.908143614825178 -0.231726352170056 0.64545332850623 0.956971941901975 0.221446287552749 "CCND1 MUT" "PD.173074_IC_50" 0.503289863019123 0.846758664699095 0.197667833128835 0.380061161995643 0.908143614825178 -0.221841207092563 0.630076808374638 0.952523560833852 0.141408819051947 "FLT3 MUT" "Shikonin_IC_50" 0.825691991740705 0.957177484110155 0.226029098615916 0.380123499330325 0.908143614825178 0.765956901943216 0.468601548042292 0.929276781658587 0.730402171180036 "SMAD4 MUT" "BI.D1870_IC_50" 0.263897251657816 0.726494572837281 0.361431881928451 0.380164895604096 0.908143614825178 0.251395969440552 0.962694726075241 0.996771409852636 0.0152904097006369 "KIT MUT" "Paclitaxel_IC_50" 0.45290878392982 0.828509891052426 -1.38631957966102 0.380181606556324 0.908143614825178 -0.733058473041014 0.769437952042241 0.969901216545994 -0.545640043793695 "MYCL1 MUT" "AS601245_IC_50" 0.668509971100508 0.906279507455901 -0.246039118165785 0.380325014561251 0.908143614825178 -0.402650204697037 0.156105793473206 0.837288218996252 -0.879082152490364 "NRAS MUT" "Camptothecin_IC_50" 0.0655280970494641 0.457742485196035 -0.695705343766751 0.38042411669095 0.908143614825178 -0.21849428337834 0.657651901649197 0.958313128388245 -0.168257432531464 "KDM5C MUT" "Cyclopamine_IC_50" 0.255814332166884 0.720311238267775 0.973816494845354 0.380584396572928 0.908143614825178 0.693017900642474 0.202292310359565 0.852959543285214 1.08699998228984 "MSH6 MUT" "Mitomycin.C_IC_50" 0.887842800358066 0.975214727041194 -0.111269681898067 0.38061331202828 0.908143614825178 0.541338541253284 0.953776195454389 0.99568364368633 0.0441870450360464 "SOCS1 MUT" "Cytarabine_IC_50" 0.497516023797307 0.844923707565453 -0.953336563567358 0.380653375682814 0.908143614825178 -0.934440777008641 0.344208354280712 0.907634915192104 -1.22862598729951 "EGFR MUT" "AUY922_IC_50" 0.642011530791277 0.896094514063559 -0.187308535630199 0.380661674518856 0.908143614825178 -0.237993866976056 0.719439907040751 0.964898274809486 -0.145423579577384 "IDH1 MUT" "GW.441756_IC_50" 0.527706623523249 0.855147571292734 0.5441014629981 0.380676117713167 0.908143614825178 0.735924508513848 0.701191202304513 0.961100601384891 0.329979120756602 "NF1 MUT" "Parthenolide_IC_50" 0.645852341865364 0.897100601386951 -0.200530972431079 0.380965677486532 0.908143614825178 -0.357229451048428 0.793440549813793 0.975393509832241 -0.133065768211878 "NF2 MUT" "Roscovitine_IC_50" 0.252213520189649 0.717470497840808 -0.615529503546101 0.380968769592032 0.908143614825178 -0.429570418530772 0.153589991299655 0.835611501078903 -0.842784991807429 "STK11 MUT" "JW.7.52.1_IC_50" 0.522423707247978 0.853303159804623 -0.775797294520543 0.381137906536972 0.908143614825178 -0.644841432663852 0.34506108028551 0.908328790918938 -1.32427179568636 "SOCS1 MUT" "PD.0332991_IC_50" 0.736302654710626 0.928872455997232 -0.470281517525766 0.381306878390089 0.908143614825178 0.977607798494264 0.791867374859706 0.975393509832241 -0.344204481082835 "EGFR MUT" "AICAR_IC_50" 0.290032798878852 0.745349408181059 -0.386829619565215 0.381365950630724 0.908143614825178 -0.287689437584814 0.145604858516046 0.831473272394224 -0.534870792109578 "MLLT3 MUT" "SB.216763_IC_50" 0.447716600361081 0.826231147407263 0.265025886429688 0.381632827078197 0.908143614825178 0.293879295489943 0.656305330837873 0.958313128388245 0.157768199092335 "SMAD4 MUT" "OSI.906_IC_50" 0.358004039010021 0.786601117838604 -0.356866209665244 0.381754797402878 0.908143614825178 -0.328977757456211 0.675641783652762 0.960256725054738 -0.175287212393091 "KDM6A MUT" "Parthenolide_IC_50" 0.703413428087599 0.915500829364901 0.172117062937064 0.381769946531358 0.908143614825178 0.367911277772334 0.781786127323999 0.9732646506813 0.141411639076679 "KDM6A MUT" "Bosutinib_IC_50" 0.0411066011756603 0.366158293476655 -0.930111014432479 0.382199947960993 0.908143614825178 -0.328914347428411 0.105239862374752 0.788057589876989 -0.706689895914365 "MSH2 MUT" "KIN001.135_IC_50" 0.681487603669025 0.909861476478352 -0.143837687074831 0.382340791448012 0.908143614825178 -0.300691152342071 0.249397882839707 0.875707386589409 -0.383350790343059 "BRCA2 MUT" "NSC.87877_IC_50" 0.273648929254363 0.734000646544246 -0.502635937500005 0.38237388162594 0.908143614825178 -0.396442297670006 0.315533484488881 0.900294798053993 -0.472223974126566 "CDKN2a(p14) MUT" "Camptothecin_IC_50" 0.0156625633674182 0.227586688087166 -0.484640561268056 0.382392966984865 0.908143614825178 -0.115221798243424 0.147006887374325 0.831473272394224 -0.286953637440393 "BRCA1 MUT" "Vinblastine_IC_50" 0.074935470452483 0.480599432660364 1.59441192000002 0.382443035673553 0.908143614825178 0.564692214114314 0.0574987999214651 0.700319715214265 1.58943337502588 "MDM2 MUT" "BMS.754807_IC_50" 0.857710354213133 0.965651207814682 -0.13166792557319 0.382515393061465 0.908143614825178 -0.534364868240348 0.792035566071631 0.975393509832241 -0.189299086800702 "EP300 MUT" "Pyrimethamine_IC_50" 0.742597977170574 0.929570057037101 0.541692237288134 0.38251551338619 0.908143614825178 1.21703823720686 0.829013755994322 0.981081757090089 -0.357400620945831 "MAP2K4 MUT" "BIBW2992_IC_50" 0.506548729520929 0.847796212975596 0.367780702772408 0.382655796131072 0.908143614825178 0.463527731022537 0.0536366708175162 0.697305726351784 1.09062878085929 "NF1 MUT" "X681640_IC_50" 0.868064314195836 0.968656533267187 0.0604163348402649 0.382671461761938 0.908143614825178 -0.273599767404152 0.43329602679555 0.922569292988365 -0.284314990289199 "PIK3CA MUT" "Dasatinib_IC_50" 0.776246352650521 0.941591338606299 0.315189477031802 0.382750646262705 0.908143614825178 0.800057991522927 0.75243360668982 0.968780465757047 0.333782917265704 "MLLT3 MUT" "Nutlin.3a_IC_50" 0.881891739306245 0.973927829424842 0.0665165555555548 0.382868880654839 0.908143614825178 0.357068046256221 0.852266858486535 0.984631915507353 -0.0848582420422488 "NF2 MUT" "BX.795_IC_50" 0.931536844517213 0.986689293492114 -0.030604794786967 0.382878269405325 0.908143614825178 0.241756044210102 0.180007406893664 0.848722027112292 0.448761947968079 "CCND1 MUT" "Cytarabine_IC_50" 0.797960780354819 0.949524851900765 0.104062165158731 0.383104043958668 0.908143614825178 -0.270303545242008 0.491827356378335 0.933639405738697 -0.278963868711011 "EP300 MUT" "WH.4.023_IC_50" 0.859799540926839 0.966322414954601 0.445024374149661 0.383185992013193 0.908143614825178 1.90787729153442 0.250651388426661 0.875707386589409 2.70021696152748 "AKT2 MUT" "PLX4720_IC_50" 0.212803815970874 0.687240250777212 0.966314331406553 0.383322714436525 0.908143614825178 0.599366207445299 0.39157615362962 0.915926348152589 0.60717997727206 "JAK2 MUT" "Vinorelbine_IC_50" 0.822672010450652 0.95705398543519 0.172553340372675 0.383348710787947 0.908143614825178 -0.491561570062127 0.940474189193238 0.995120990231635 0.0614514160754482 "MET MUT" "VX.680_IC_50" 0.287541675146396 0.742453942209604 1.98203356802721 0.383391070284313 0.908143614825178 1.05022168503771 0.267543086936619 0.877052916121269 2.13458713848727 "JAK2 MUT" "Embelin_IC_50" 0.155306979150805 0.630721638230745 0.772969581453649 0.383606942775746 0.908143614825178 0.378877671205428 0.133190524758386 0.826023079873761 0.878535984520795 "HRAS MUT" "MK.2206_IC_50" 0.0678554540630708 0.461747350209541 -1.46301073443984 0.383676099499392 0.908143614825178 -0.560554806367517 0.0560143172997874 0.697813103075383 -1.4898755209716 "ALK MUT" "PAC.1_IC_50" 0.558672014011319 0.869163612542691 -0.714931053913047 0.383808922466566 0.908143614825178 -0.88982317158024 0.417334325111417 0.922428741067589 -1.34658785602718 "JAK2 MUT" "CCT018159_IC_50" 0.340819779621297 0.778503205456979 -0.513124678323994 0.383846631609518 0.908143614825178 -0.439841281942233 0.150998553542055 0.831473272394224 -0.849486421534151 "MS-HL MUT" "VX.680_IC_50" 0.748989627686569 0.932323030730707 -0.144558434500649 0.383907789775006 0.908143614825178 -0.258290393916364 0.67750336956524 0.960730407205068 0.219551319089393 "EZH2 MUT" "BMS.754807_IC_50" 0.399845356962067 0.805918367644724 0.736820019548884 0.383925992013055 0.908143614825178 0.633839637400661 0.814433014912959 0.977383317127464 0.217000728841829 "FGFR3 MUT" "Erlotinib_IC_50" 0.945862845484797 0.990164814713378 -0.0828678909090917 0.38406276466812 0.908143614825178 0.954300433841895 0.836117550638212 0.981626636221501 0.24705424444784 "MLL_AFF1 MUT" "Temsirolimus_IC_50" 0.704252171803635 0.915500829364901 -0.613259537001893 0.384206921367226 0.908143614825178 1.09139185691227 0.359615437878767 0.91161229252998 1.42066319886665 "MYC MUT" "Sorafenib_IC_50" 0.241561502705401 0.711340033600749 0.452310625735295 0.384303701450631 0.908143614825178 0.326373619893547 0.576962671718286 0.949294892873838 0.234834023507264 "EP300 MUT" "PD.0325901_IC_50" 0.746426689938924 0.931110103613801 0.420658815476181 0.384327237676475 0.908143614825178 1.06886201665035 0.774985984435008 0.972151464181929 0.323505442565743 "MLL_AFF1 MUT" "MS.275_IC_50" 0.770504734936639 0.939898671414565 -0.454011819112632 0.384475621634805 0.908143614825178 1.1452253227152 0.807300620662722 0.977383317127464 -0.395853073737123 "ALK MUT" "VX.702_IC_50" 0.470936898429325 0.832584329931559 -0.765223874045815 0.384595090113696 0.908143614825178 -0.756466718259986 0.881363714481372 0.988301482344111 -0.148240356804323 "HRAS MUT" "VX.702_IC_50" 0.0961346384614719 0.529963826304365 1.02244863461539 0.384665980122623 0.908143614825178 0.437852951760306 0.204581512976425 0.853446327418758 0.725118978095761 "TP53 MUT" "CI.1040_IC_50" 0.0771803795313551 0.486043076549996 0.292009480683761 0.384671403667096 0.908143614825178 0.134180100629954 0.870791356207719 0.98753907730331 -0.0255255713876686 "KDR MUT" "SB590885_IC_50" 0.194979478932302 0.670441006096806 1.36482627112913 0.384705762319407 0.908143614825178 0.765861379199788 0.128493767146831 0.820169751013594 1.41633933946814 "EGFR MUT" "PLX4720_IC_50" 0.299063670788843 0.750344870252218 -0.427349355141878 0.384710189555348 0.908143614825178 -0.31930681393198 0.246231287708211 0.875707386589409 -0.453545138820744 "MSH6 MUT" "Doxorubicin_IC_50" 0.65731353923853 0.901751651084414 -0.307970262302286 0.38494210689182 0.908143614825178 0.375971429023661 0.722621963266866 0.965402608571648 -0.233123397268362 "NRAS MUT" "Bosutinib_IC_50" 0.718760958085894 0.92132587844031 -0.108989497470669 0.385028581451642 0.908143614825178 0.222602948369791 0.842704308848671 0.982859190294459 0.0632003878686856 "CCND1 MUT" "KIN001.135_IC_50" 0.475182977285381 0.834671681422364 0.178425017301038 0.385068802953573 0.908143614825178 0.216525573823592 0.266145433077942 0.877052916121269 0.308520438450144 "CDKN2A MUT" "Axitinib_IC_50" 0.0950085085554484 0.527890690029858 -0.258779498848161 0.385099521836687 0.908143614825178 0.118834560564614 0.616641376429508 0.950247055931602 -0.0775952276446455 "MDM2 MUT" "AZD.2281_IC_50" 0.0411469403096162 0.366158293476655 0.97458381 0.385398889155879 0.908144673149887 0.313353824613506 0.0279954775209002 0.593383856475215 0.916348473297884 "SMARCA4 MUT" "WZ.1.84_IC_50" 0.61253265016952 0.88496040166963 0.492329306029575 0.38546161473456 0.908144673149887 0.70301333089409 0.428232567231861 0.922428741067589 1.25586462657369 "KRAS MUT" "AICAR_IC_50" 0.234072602311224 0.707628390886945 0.240760682636015 0.385587805943676 0.908144673149887 -0.167354513296077 0.694150182408003 0.961100601384891 0.0887564685894076 "BRCA1 MUT" "RO.3306_IC_50" 0.829647672788748 0.958015830101332 -0.158735411764705 0.385811599398716 0.908144673149887 -0.611955872389841 0.787386597506572 0.975265472692061 -0.198037003278368 "MLLT3 MUT" "A.443654_IC_50" 0.795149310896009 0.948646027682356 -0.169384356643356 0.385833079974474 0.908144673149887 -0.364285896248608 0.665786686138769 0.959206771190239 -0.303561226204783 "RUNX1 MUT" "JNJ.26854165_IC_50" 0.217388558672829 0.689975030887399 -0.813328119850197 0.38583579535538 0.908144673149887 -0.531810356789213 0.255952245692617 0.875707386589409 -0.702147670933767 "JAK2 MUT" "JNK.Inhibitor.VIII_IC_50" 0.698484191950725 0.914968665673257 -0.181705489443381 0.385927002456859 0.908144673149887 -0.388086727520882 0.486950766768918 0.933639405738697 -0.362329328771064 "AKT2 MUT" "PAC.1_IC_50" 0.115718887703115 0.569171423258979 -1.03141580000001 0.386010439369659 0.908144673149887 -0.476286827144074 0.0185333603654817 0.515971076507346 -1.50435158668509 "ALK MUT" "PF.4708671_IC_50" 0.657649165007261 0.901751651084414 -0.368983520179367 0.386042001319773 0.908144673149887 -0.714490704704837 0.643076542448068 0.955972780483685 -0.39758376444967 "MS-HL MUT" "XMD8.85_IC_50" 0.680216308391631 0.909378448716856 0.131933680723525 0.386122540909129 0.908144673149887 0.242970680497526 0.370806358294048 0.913948248824328 0.314322236917484 "IDH1 MUT" "CEP.701_IC_50" 0.698540520252181 0.914968665673257 -0.506614216318781 0.386355476714465 0.908361399210513 0.827124501205338 0.757185787356893 0.969901216545994 -0.369154604202868 "STK11 MUT" "Lenalidomide_IC_50" 0.79315422203713 0.948304071878264 0.0606172673480362 0.386419250784519 0.908361399210513 -0.175813496709855 0.983514862423675 0.998011368051263 0.0048934374709777 "KRAS MUT" "Temsirolimus_IC_50" 1.38930737592611e-05 0.00216463838694733 1.15742593897317 0.386526662770345 0.908372138048995 0.188589693307874 0.0297076394238556 0.59799127175549 0.642678984216246 "MLL_AFF1 MUT" "Bleomycin_IC_50" 0.0475998174523542 0.386936918743962 -4.62011482434788 0.38663348474145 0.908372138048995 -1.67654046776676 0.109611482690622 0.795960407011784 -3.62030254493278 "MYCN MUT" "CGP.082996_IC_50" 0.0307059411712907 0.324937468327906 0.797055790476192 0.386976605298629 0.908372138048995 0.277009165715955 0.959645664881887 0.99641548698706 -0.0223316208661688 "AKT2 MUT" "GSK269962A_IC_50" 0.40730096488166 0.809352267869285 1.35840759322034 0.386977051448158 0.908372138048995 1.31423770990948 0.539393591120409 0.944569766818715 1.00668800040468 "RUNX1 MUT" "BI.D1870_IC_50" 0.251627591271355 0.717470497840808 -1.06755117239188 0.387057448504433 0.908372138048995 -0.69290229116081 0.21291173061247 0.857926079659413 -1.09098455801437 "MLLT3 MUT" "X681640_IC_50" 0.464139189859085 0.829490249358073 0.286595507337526 0.387159746523381 0.908372138048995 0.28892203680463 0.687431782789273 0.961100601384891 0.155483989814311 "CCND3 MUT" "AMG.706_IC_50" 0.237060404050446 0.7095832316724 1.07350255859373 0.387270685603559 0.908372138048995 0.72267056296727 0.228880685891875 0.868145256417768 1.00152899270272 "MYC MUT" "Methotrexate_IC_50" 0.837254122059179 0.959212493377535 0.0767917375241555 0.387301862343218 0.908372138048995 0.246586182295973 0.927604986660438 0.994186152404781 -0.0282894970183315 "BRAF MUT" "Epothilone.B_IC_50" 0.571596925157088 0.872389778906173 -0.18717204952978 0.38734436288611 0.908372138048995 0.179906878528537 0.394561493336018 0.915926348152589 -0.328755449698318 "JAK2 MUT" "Parthenolide_IC_50" 0.570379578688065 0.872389778906173 -0.524886554054058 0.387603010777893 0.908738737782066 -0.735145619096404 0.577159160543461 0.949294892873838 0.654455664742939 "MET MUT" "AG.014699_IC_50" 0.224554475225915 0.696147159126308 0.532727431038073 0.387975492876752 0.909067201511433 0.334323078037645 0.6980803845307 0.961100601384891 0.157074166313606 "RB1 MUT" "Temsirolimus_IC_50" 0.736008344664523 0.928872455997232 0.106991875173877 0.38797768457303 0.909067201511433 0.214487401805683 0.426693013197227 0.922428741067589 0.264779540369846 "FGFR3 MUT" "Metformin_IC_50" 0.31276259129926 0.759215564942334 -1.02939448669199 0.388232192932107 0.909067201511433 -0.820058864549545 0.244699262298334 0.875707386589409 -1.15949095673235 "KIT MUT" "DMOG_IC_50" 0.999110456648454 0.999548905963057 -0.000896291161178622 0.388256499531268 0.909067201511433 0.625681346192677 0.976940781393128 0.99742775226181 -0.0219609336715983 "KRAS MUT" "PHA.665752_IC_50" 0.328878527235008 0.770229380276924 0.290114674305447 0.388428166998673 0.909067201511433 0.269499416990889 0.0593013576175706 0.70215997387469 0.626474225612909 "CDKN2A MUT" "Vinorelbine_IC_50" 0.0117691679415862 0.194278774143545 -0.426159451680599 0.388478649800668 0.909067201511433 -0.112743373153667 0.495778635232994 0.933639405738697 -0.130116752863217 "MLLT3 MUT" "Bleomycin_IC_50" 0.183692459361381 0.660385845878234 -0.974031930455646 0.388535819581836 0.909067201511433 -0.514859078955265 0.487030006735712 0.933639405738697 -0.512817771753452 "KDM6A MUT" "AZ628_IC_50" 0.711614424201878 0.919384303365853 0.28291626610492 0.388606419896176 0.909067201511433 0.490912728908906 0.895323976098339 0.988301482344111 -0.0955189663463192 "NRAS MUT" "AZD8055_IC_50" 0.117170150301857 0.572601844763368 -0.405715757105264 0.388664358083427 0.909067201511433 -0.179961110333531 0.155065933552011 0.836658903934028 -0.409316349836429 "PIK3R1 MUT" "Bortezomib_IC_50" 0.903148839755985 0.979694707150557 0.123580429553266 0.388801983993683 0.909149662940469 -0.708751351967178 0.965295040443909 0.997126446878798 -0.0416427663371348 "FAM123B MUT" "CCT018159_IC_50" 0.8245306182605 0.957177484110155 0.157535091743118 0.389044204093572 0.90916706912451 -0.570859252876003 0.858712935565126 0.985224768537332 -0.129630288726236 "KDM5C MUT" "FTI.277_IC_50" 0.329005330789737 0.770229380276924 0.539441567474057 0.389137274080737 0.90916706912451 0.433730884077203 0.427219206231823 0.922428741067589 0.415116780676194 "JAK2 MUT" "GDC0941_IC_50" 0.328140990091294 0.769735904120651 0.729205681159417 0.389148975205189 0.90916706912451 0.516804955441805 0.954301840809628 0.99568364368633 -0.0468934599204288 "CDKN2a(p14) MUT" "XMD8.85_IC_50" 0.0023822406804848 0.0742339630995983 -0.686244651063827 0.389231676284105 0.90916706912451 -0.182379394954008 0.111841571666734 0.797376436030023 -0.404303351333958 "MAP2K4 MUT" "AICAR_IC_50" 0.763914041258696 0.936244886169491 0.156973711524694 0.389321288580172 0.90916706912451 -0.402664695513594 0.965057405297447 0.997126446878798 0.0233269170754429 "PIK3R1 MUT" "AMG.706_IC_50" 0.711333266153151 0.919312211985394 -0.169093804347824 0.389518050181548 0.909379671494695 -0.361595795504012 0.614233301261752 0.950059945073224 -0.211455562117976 "MSH2 MUT" "DMOG_IC_50" 0.903247411569503 0.979694707150557 -0.0774608449477348 0.389721867555003 0.909379671494695 0.495790914369803 0.730706464453093 0.96639568318693 -0.208612014445621 "FGFR3 MUT" "Nutlin.3a_IC_50" 0.2809251971168 0.737978092452245 1.42460985546873 0.389764334689639 0.909379671494695 1.04054086526999 0.582608166113539 0.949294892873838 0.700855041088133 "SMAD4 MUT" "PF.562271_IC_50" 0.0928609084222118 0.521674050404563 -0.49074383918439 0.389821913003075 0.909379671494695 -0.211265602298286 0.242792950461086 0.875707386589409 -0.35992487766916 "TET2 MUT" "CGP.082996_IC_50" 0.251948321261128 0.717470497840808 -1.08624417519908 0.389945187741594 0.909428364583271 -0.693593862769694 0.384307388815349 0.915331032347709 -0.995317596608704 "NF2 MUT" "AICAR_IC_50" 0.190858125973694 0.666016116609973 0.499335456110153 0.390131343864227 0.90959733626414 0.295535409891749 0.325223787549746 0.900918773778407 0.385513903042763 "MLH1 MUT" "Axitinib_IC_50" 0.632101916009559 0.893900814662562 0.259401624254122 0.390300804933964 0.90959733626414 0.397510169687876 0.164088887422644 0.839927262232576 0.667300725557229 "AKT2 MUT" "AMG.706_IC_50" 0.757406634705106 0.934762260113025 -0.178006070726914 0.390324901306456 0.90959733626414 -0.455353076969124 0.711942682116277 0.962630898212352 -0.197960125510617 "KDR MUT" "BAY.61.3606_IC_50" 0.945550955291021 0.990147156460271 -0.0755720023228797 0.390522830452376 0.909669777585668 0.658786346484926 0.772061233277719 0.969964041977567 -0.304123224635756 "FLCN MUT" "Dasatinib_IC_50" 0.275144918506129 0.73402283606276 2.47358312855517 0.390560844717279 0.909669777585668 1.60163183083137 0.846504776396861 0.98378870157398 0.674637416875978 "MS-HL MUT" "CMK_IC_50" 0.435334560811679 0.823150425912549 0.228851167913799 0.390745665663117 0.909861629982733 0.231920966421193 0.477759616674659 0.930304161706959 0.241344986291861 "KDM5C MUT" "BMS.754807_IC_50" 0.421654630923073 0.816306467685614 -0.927915273996524 0.390965516769287 0.909899301718376 -0.828490491240093 0.262970786299794 0.877052916121269 -1.26304684525558 "MS-HL MUT" "Pazopanib_IC_50" 0.811562855910871 0.95324556584373 -0.0576345610236222 0.391128984399226 0.909899301718376 0.177755421209072 0.201227238959918 0.851001889249827 -0.31408353721048 "CDK4 MUT" "FTI.277_IC_50" 0.199586722023933 0.674012093366938 -0.502851736062719 0.391255930615548 0.909899301718376 -0.30779864476858 0.273933733798805 0.882167181782537 -0.432156769368894 "CDKN2a(p14) MUT" "GSK.650394_IC_50" 0.0318032781106557 0.32918987517568 -0.387029334900116 0.391341614914812 0.909899301718376 0.104632871475128 0.380177818438491 0.915134825237766 -0.176044950165056 "EWS_FLI1 MUT" "WZ.1.84_IC_50" 0.135390758092329 0.602620739586366 0.76730259011163 0.39152548377918 0.909899301718376 0.405284285658328 0.297337108329699 0.894167310052 0.586717550898899 "MLL_AFF1 MUT" "Pyrimethamine_IC_50" 0.405010450492833 0.807904911469051 -1.3727949322034 0.391598395236047 0.909899301718376 1.21713482940873 0.83634053739364 0.981626636221501 -0.34315639592675 "SMARCA4 MUT" "Sorafenib_IC_50" 0.805159340219463 0.952510646223648 -0.264834690476193 0.391614707559736 0.909899301718376 -0.875364324330103 0.511633197402147 0.939086342216131 1.24637139634758 "HRAS MUT" "Etoposide_IC_50" 0.298762415723454 0.750344870252218 1.14254992720969 0.391733075650467 0.909899301718376 0.614708680923649 0.168594016340152 0.84067330207935 1.43448436569443 "CDKN2C MUT" "IPA.3_IC_50" 0.100474352732333 0.539275980611557 1.08034762962962 0.391771570289055 0.909899301718376 0.47533914956373 0.131703102263291 0.824721122422311 1.09964871166103 "ALK MUT" "Metformin_IC_50" 0.393730597312409 0.803073858340542 0.869849619771845 0.391845494155623 0.909899301718376 0.816136574745413 0.350879106845456 0.910340341961272 0.938499031999347 "VHL MUT" "Rapamycin_IC_50" 0.6024601044193 0.880745626033854 -0.70849695254237 0.391965466376747 0.909899301718376 -1.02787179051886 0.604306170482086 0.949657634568742 -0.835656851875467 "FLCN MUT" "Lapatinib_IC_50" 0.568930246568583 0.872389778906173 -0.588698973471744 0.392299419863789 0.909899301718376 -0.762290744860485 0.178900600904354 0.848722027112292 -2.14825815545959 "KIT MUT" "Vinblastine_IC_50" 0.70991975418487 0.91855665481614 -0.333500870476192 0.39239928454418 0.909899301718376 0.557540059460825 0.792381977442529 0.975393509832241 -0.223249206977436 "KDR MUT" "Cisplatin_IC_50" 0.25833960682418 0.72307407759393 -1.08455885994931 0.392572749687351 0.909899301718376 -0.710793074512817 0.230228607042357 0.868326388686386 -1.11419721127992 "FLT3 MUT" "BAY.61.3606_IC_50" 0.0391185651130501 0.358612505815459 -1.97499295593372 0.39282212529659 0.909899301718376 -0.574297580425891 0.196280375762472 0.851001889249827 -1.17076067778983 "IDH1 MUT" "KU.55933_IC_50" 0.403537211832321 0.807711061141052 0.74258195266273 0.392873037944165 0.909899301718376 0.671641551775544 0.363636018258674 0.91230607860569 0.800748070242653 "FLCN MUT" "CI.1040_IC_50" 0.184553493587769 0.660385845878234 1.18988927011495 0.392994769016581 0.909899301718376 0.68538153480721 0.809950176610073 0.977383317127464 0.268296988849718 "MYCN MUT" "GNF.2_IC_50" 0.0536061526025597 0.413543213551623 0.546096202077923 0.39300904959703 0.909899301718376 0.241740847865132 0.597237999159331 0.949294892873838 0.183733068726107 "BCR_ABL MUT" "CMK_IC_50" 0.712555129671783 0.919646314953749 0.316744191780826 0.393098144599365 0.909899301718376 0.847189638113018 0.401646067445686 0.916589616820582 0.751191701619865 "CDK4 MUT" "Salubrinal_IC_50" 0.604581587382722 0.882236128417016 0.631798122866899 0.39314563093561 0.909899301718376 0.865442096279456 0.398305006909511 0.916480913435499 1.0289413594767 "ERBB2 MUT" "PHA.665752_IC_50" 0.404517790311624 0.807904911469051 0.574675101351353 0.393223316908911 0.909899301718376 0.594861224759077 0.448145264811354 0.925809648901546 0.555103677959678 "APC MUT" "PF.02341066_IC_50" 0.429170478355226 0.820918238409269 0.394830748977666 0.393414694968852 0.909899301718376 0.406562208379314 0.61908885010499 0.950394619652337 0.285135634395794 "KDM5C MUT" "BMS.708163_IC_50" 0.453247272326557 0.828509891052426 -0.527194803131983 0.393427586965726 0.909899301718376 -0.606787628864829 0.5694284053634 0.949294892873838 -0.403002154320945 "KDM5C MUT" "Obatoclax.Mesylate_IC_50" 0.619398008278927 0.887477435756715 -0.573939782722523 0.393508360839424 0.909899301718376 -0.725842198344481 0.640312646476328 0.955094994589269 -0.516173422379209 "NOTCH1 MUT" "Parthenolide_IC_50" 0.971705534426549 0.995220468612913 0.0173735732323227 0.393609119883488 0.909899301718376 0.399504831895207 0.964775180092814 0.997126446878798 -0.0256512910827972 "SMARCA4 MUT" "PF.562271_IC_50" 0.338799688486614 0.776685604917301 0.468103075174823 0.393701299569403 0.909899301718376 0.339756374043586 0.605379401222489 0.949657634568742 0.283919164046714 "KDM5C MUT" "Pyrimethamine_IC_50" 0.280571948067739 0.737882141891724 -1.45434588435375 0.393835512304485 0.909899301718376 -0.974692247101057 0.357483955969051 0.91161229252998 -1.23566612657859 "TET2 MUT" "DMOG_IC_50" 0.179588057010689 0.658614416960816 -1.38937029360963 0.393887466404956 0.909899301718376 -0.804000050377289 0.866386149861329 0.987077901072027 -0.201546802554368 "VHL MUT" "Cytarabine_IC_50" 0.49639861041939 0.843896642253943 -0.480651092130508 0.394005039946646 0.909899301718376 -0.459462180925426 0.581160108265514 0.949294892873838 -0.391370452316399 "PIK3R1 MUT" "RDEA119_IC_50" 0.276103295352508 0.735108059249974 0.907366559118231 0.394036038538484 0.909899301718376 0.64166727953939 0.528956852162994 0.943054040048671 0.447127813749032 "CTNNB1 MUT" "AZD.0530_IC_50" 0.777817149516289 0.941886297362171 -0.235277402730376 0.394164822193569 0.909899301718376 0.610319852189806 0.988132771113869 0.998249020619073 0.0129805877215821 "NF2 MUT" "Doxorubicin_IC_50" 0.238361847017763 0.710855542080976 -0.510820693131214 0.39418329432486 0.909899301718376 -0.231072253463147 0.992512214274265 0.999469155159075 -0.00417522589965762 "FGFR3 MUT" "PLX4720_IC_50" 0.35745236147153 0.786601117838604 1.23189701338432 0.394257556810961 0.909899301718376 1.01202744128079 0.781393739700641 0.973017078278378 0.335885825787778 "APC MUT" "Bicalutamide_IC_50" 0.134786562802229 0.601893367640051 -0.171119444641377 0.394392615218721 0.909899301718376 -0.0968177543765156 0.908301903925955 0.989534075687441 -0.0150505465981004 "KIT MUT" "JNK.Inhibitor.VIII_IC_50" 0.527282862886765 0.855121165130409 -0.362437686424473 0.394428178395229 0.909899301718376 -0.46628390006678 0.427260829712524 0.922428741067589 -0.461958035097083 "TSC1 MUT" "QS11_IC_50" 0.456267637455875 0.828966839128293 1.03468713565218 0.394450209617807 0.909899301718376 0.869484169749333 0.301437254047672 0.894167310052 1.39641902296523 "KRAS MUT" "Cyclopamine_IC_50" 0.261874910101672 0.724288808298587 0.36726012700535 0.395187093217861 0.910701782715558 0.275386021953915 0.16989140943907 0.84067330207935 0.496037929380982 "TET2 MUT" "PHA.665752_IC_50" 0.52160668670488 0.853303159804623 0.509432087542079 0.395242689654315 0.910701782715558 0.678111681295349 0.857941203676529 0.984898622336936 0.177739286453358 "CDK6 MUT" "PAC.1_IC_50" 0.484568192269391 0.83972091053812 0.429463983304043 0.395355835567161 0.910701782715558 0.437115509274321 0.924312119883947 0.994026707431102 -0.0602008036086282 "MLL_AFF1 MUT" "BMS.754807_IC_50" 0.236150561544512 0.70906038758165 -1.93064961217393 0.395450780089662 0.910701782715558 -1.17405398088905 0.0874647895583345 0.755326311453013 -2.74703521691714 "NF2 MUT" "VX.702_IC_50" 0.538085326758223 0.860998762866154 0.205452483734089 0.395605855724455 0.910701782715558 -0.233960199171141 0.473032869541377 0.929276781658587 -0.237986769629698 "MSH6 MUT" "BMS.536924_IC_50" 0.857791724124909 0.965651207814682 0.222960587030715 0.395689357005836 0.910701782715558 0.779216289886742 0.963962828076017 0.997051031866061 -0.0529766158262666 "BCR_ABL MUT" "VX.680_IC_50" 0.00266610547584101 0.0794553111776645 -3.94539976369868 0.395726633050587 0.910701782715558 -0.926533947253129 0.007090402232846 0.381508554648877 -3.71930369709947 "BRAF MUT" "Dasatinib_IC_50" 0.185050015259946 0.660550500647272 -1.17146925056277 0.395821418936297 0.910701782715558 0.67480824426601 0.973843517956219 0.99742775226181 0.0325761546711105 "KDR MUT" "JNK.9L_IC_50" 0.101661164738615 0.542024654294532 -1.29987465112262 0.395858321250713 0.910701782715558 -0.527337766588517 0.0812157573399194 0.741811190933953 -1.38703075671517 "MET MUT" "Elesclomol_IC_50" 0.0710763213946143 0.471770411289663 1.14629464990329 0.395954939880642 0.910701782715558 0.449573065490983 0.150307608608505 0.831473272394224 0.862504369166079 "FBXW7 MUT" "BMS.708163_IC_50" 0.495416864910908 0.843282996121548 0.224614993774572 0.396007169468774 0.910701782715558 0.281851570999061 0.486283445515133 0.933639405738697 0.242891541260993 "NRAS MUT" "Vorinostat_IC_50" 0.00341658981651844 0.0951182889043896 -0.646318330225562 0.396129384986896 0.910701782715558 -0.149852693325079 0.0375466368742057 0.645472009508728 -0.47937824050898 "FGFR3 MUT" "RDEA119_IC_50" 0.472646867535692 0.834010894215077 1.18992813465348 0.396131177415854 0.910701782715558 1.26942550126659 0.327011975933938 0.902483952227875 1.3843689592856 "EGFR MUT" "EHT.1864_IC_50" 0.394782971222081 0.80340686696226 0.24611488372093 0.396437222723123 0.910837652394916 0.245295100738579 0.388978312277762 0.915926348152589 0.256856953542882 "KDM6A MUT" "Bexarotene_IC_50" 0.28803670922637 0.74340424720703 -0.379171360140462 0.396455912347572 0.910837652394916 -0.27131396583008 0.134824690930775 0.828635349589072 -0.539590983649634 "MSH2 MUT" "CI.1040_IC_50" 0.721085630363742 0.922822998769296 0.242901063308559 0.3964979579055 0.910837652394916 0.515131375794088 0.857699826400863 0.984898622336936 0.108327000145869 "NOTCH1 MUT" "ABT.888_IC_50" 0.0123603543053483 0.200541834057986 -0.714335969924821 0.396732706466907 0.911075842173953 0.213289737392188 0.795185092725801 0.975627957210581 -0.07556274140377 "MYCL1 MUT" "BIRB.0796_IC_50" 0.511109144429609 0.849393770898084 -0.303970412087908 0.396987847592844 0.911075842173953 -0.373993519848647 0.735703657908384 0.96672489654949 0.169941611591814 "CCND1 MUT" "BMS.708163_IC_50" 0.672633206600453 0.907767897812007 0.101794144208038 0.397045750068709 0.911075842173953 0.207882080153359 0.875624488229164 0.987838063957761 0.0411218678803544 "IDH1 MUT" "QS11_IC_50" 0.333136407336195 0.773185226006147 -1.34390756000001 0.39710390003869 0.911075842173953 -0.860027496587747 0.415145565619096 0.92211126027385 -1.11116609047817 "PDGFRA MUT" "Nilotinib_IC_50" 0.767990542088625 0.938561167509162 -0.217180742366412 0.397313937854841 0.911075842173953 -0.502827645542095 0.722046160182425 0.965402608571648 -0.239125793405249 "NRAS MUT" "AICAR_IC_50" 0.47939579794085 0.836304203722611 0.21226577922078 0.397320101850894 0.911075842173953 0.235648512307836 0.568727066903565 0.949294892873838 0.18749722922497 "MYCL1 MUT" "Shikonin_IC_50" 0.335272225818 0.773264085106582 0.62848148496503 0.397461529022142 0.911075842173953 0.46407834831485 0.905643284386161 0.988917021334873 0.0824152992834243 "CTNNB1 MUT" "CGP.60474_IC_50" 0.35963810118868 0.786601117838604 -0.702268602298856 0.39750085271138 0.911075842173953 -0.479195646359981 0.583935915870391 0.949294892873838 -0.454733149241765 "CDK4 MUT" "BIRB.0796_IC_50" 0.27430165954034 0.73402283606276 0.424173114119923 0.397524928321593 0.911075842173953 0.315270762356475 0.41648649892268 0.922398153848459 0.32688684919116 "NF1 MUT" "PD.0325901_IC_50" 0.763579147782701 0.936244886169491 -0.147299911152765 0.397926914680092 0.911761849657869 -0.392681035347799 0.557695674601238 0.949255388017112 -0.27321689921877 "KDM5C MUT" "Docetaxel_IC_50" 0.199572769575717 0.674012093366938 -1.64132732046332 0.398463758890344 0.912301084962464 -0.81500645276269 0.118180343281553 0.806524749270063 -1.90965386886125 "EGFR MUT" "KIN001.135_IC_50" 0.458097904909558 0.828966839128293 -0.185392802768165 0.398568750864159 0.912301084962464 -0.204860867439408 0.799469971498334 0.976360691959787 0.0601740622230712 "RUNX1 MUT" "NU.7441_IC_50" 0.423905186269332 0.818235592101269 0.662297577075105 0.398802980819404 0.912301084962464 0.611394792184666 0.532937207028014 0.943443271455699 0.49336972286036 "SMO MUT" "Midostaurin_IC_50" 0.238688503706197 0.710855542080976 -1.55853599827589 0.399065007830404 0.912301084962464 -0.855919598436796 0.105288145130105 0.788057589876989 -1.93841486835872 "HRAS MUT" "Shikonin_IC_50" 0.33953464397784 0.778100438213095 0.877180650259957 0.399276796796771 0.912301084962464 0.654251599831346 0.139364686232264 0.831473272394224 1.32470402256033 "EGFR MUT" "JNJ.26854165_IC_50" 0.649990526094457 0.898913406720956 -0.118247289719626 0.399513090399186 0.912301084962464 -0.206097899724326 0.515831423026208 0.939635632721979 -0.169790081000173 "MYCL1 MUT" "Thapsigargin_IC_50" 0.564861981323694 0.871775968539349 -0.528343955908293 0.399667234175816 0.912301084962464 -0.589399584559237 0.136539719993356 0.830541253822459 -1.44887677577682 "CDKN2A MUT" "A.443654_IC_50" 0.104271281488347 0.546977702834026 -0.39769040409435 0.399702953225119 0.912301084962464 0.142802222128536 0.791387455416615 0.975393509832241 -0.0767368993890059 "MLL_AFF1 MUT" "Methotrexate_IC_50" 0.000277537883901738 0.0198775318300914 -5.66899772545087 0.399812993154586 0.912301084962464 -1.02521908677826 0.207375316123284 0.853446327418758 -1.58836242741806 "JAK2 MUT" "Midostaurin_IC_50" 0.71295629754043 0.919646314953749 0.2613778004969 0.399949218104539 0.912301084962464 -0.460820190885367 0.961395355544876 0.996625877572729 0.0340058146336264 "BRCA1 MUT" "XMD8.85_IC_50" 0.465235722105822 0.830003705910366 -0.942931746575349 0.40000617152558 0.912301084962464 -0.934128230932826 0.343121803169007 0.907180409180092 -1.21846336948281 "BRCA1 MUT" "Elesclomol_IC_50" 0.600887206945348 0.880741900288913 -0.571832125714294 0.400007825565887 0.912301084962464 -0.765237104984946 0.581761956509451 0.949294892873838 -0.566648763979074 "FBXW7 MUT" "Vorinostat_IC_50" 0.273266033395998 0.734000646544246 -0.302078091095377 0.400052355442462 0.912301084962464 -0.177828647652477 0.9055180028068 0.988917021334873 0.031822143085592 "STK11 MUT" "QS11_IC_50" 0.0763549166093749 0.483683312058227 0.723707934900546 0.400302511524884 0.912301084962464 0.253101387573038 0.195069673900685 0.851001889249827 0.549845627123464 "MYCL1 MUT" "X17.AAG_IC_50" 0.865747968464621 0.967741687593997 -0.141192023351648 0.400583736817326 0.912301084962464 -0.615512591906827 0.100840146112905 0.774133667469059 -1.32169265253201 "AKT2 MUT" "CCT018159_IC_50" 0.636961900494236 0.895268363706423 0.274394700460832 0.400608707524525 0.912301084962464 0.45561219400525 0.525530841049341 0.940554660491705 0.375801695811323 "MSH6 MUT" "PD.0325901_IC_50" 0.650221790876638 0.898913406720956 0.418353978043913 0.400634832675257 0.912301084962464 0.728982884096125 0.921249454160832 0.993931766508607 -0.0793125946375615 "EWS_FLI1 MUT" "AP.24534_IC_50" 0.832557674007166 0.958751873919626 0.15308087477954 0.400692663182518 0.912301084962464 0.600685939005859 0.368433532080327 0.913948248824328 0.698241574139322 "CDK4 MUT" "Nutlin.3a_IC_50" 0.808767746188821 0.952641225877339 -0.144208996031746 0.400742407261292 0.912301084962464 -0.459559786842237 0.855223161362736 0.984631915507353 -0.110292920968933 "FGFR2 MUT" "WZ.1.84_IC_50" 0.490249466781903 0.84263880174142 0.670535449374287 0.401117867498259 0.912301084962464 -0.693915033174882 0.850239871871652 0.984453468864253 -0.212804012242158 "MYC MUT" "BI.D1870_IC_50" 0.472508567834353 0.834010894215077 -0.190114832648868 0.401189126597506 0.912301084962464 -0.192453103997718 0.422811279480894 0.922428741067589 -0.210549596101145 "MYC MUT" "SL.0101.1_IC_50" 0.261722545796218 0.724288808298587 -0.224594886128363 0.401215811050117 0.912301084962464 -0.147194456484253 0.157505074358916 0.838108187766047 -0.28433867789268 "FGFR3 MUT" "JNK.Inhibitor.VIII_IC_50" 0.41835221555003 0.814099702076568 0.654848457142872 0.401266906596745 0.912301084962464 0.647654760898099 0.444888278432144 0.925809648901546 0.620756640043021 "MSH6 MUT" "IPA.3_IC_50" 0.303510888656714 0.753137804459424 -0.755840490333924 0.401302332516061 0.912301084962464 -0.517317131315387 0.378258656860734 0.914597095447912 -0.597858422935785 "CCND1 MUT" "WZ.1.84_IC_50" 0.417538057310806 0.814099702076568 -0.40009734741784 0.401338871703273 0.912301084962464 -0.35130002306789 0.612593303763089 0.949930222127033 0.276118421192013 "CDKN2A MUT" "NVP.BEZ235_IC_50" 5.59197482652872e-05 0.00636696518389764 -0.551350554284538 0.401512223231924 0.912301084962464 -0.0870731675758167 0.196710890360762 0.851001889249827 -0.192934333320875 "CDK6 MUT" "Cytarabine_IC_50" 0.533762306323811 0.858279561609675 0.415003506837604 0.401585452521721 0.912301084962464 -0.422739067191399 0.584468540067351 0.949294892873838 0.337203598756876 "MET MUT" "AUY922_IC_50" 0.733949257603807 0.928593402067957 -0.195913301156442 0.401704834693023 0.912301084962464 0.325977317352481 0.713997404400831 0.962630898212352 -0.202269205879443 "SMARCA4 MUT" "KU.55933_IC_50" 0.882558602086627 0.973927829424842 -0.0592192985971941 0.401740788953488 0.912301084962464 -0.297163850213264 0.475872109951817 0.929855889225741 -0.3212383475565 "FGFR3 MUT" "BAY.61.3606_IC_50" 0.220105576204202 0.692830939023895 -1.35602614285713 0.401802221179605 0.912301084962464 -0.644507850674118 0.158909293642271 0.83854630828105 -1.45814568062231 "PDGFRA MUT" "DMOG_IC_50" 0.955124139841974 0.992680805843952 0.0452400693240893 0.401808923402386 0.912301084962464 0.606258466143629 0.708418360351194 0.962630898212352 0.288057470964858 "BRCA2 MUT" "PF.4708671_IC_50" 0.335501359464712 0.773264085106582 -0.508663318284414 0.401985144043944 0.912301084962464 -0.441929445782581 0.287203223107376 0.888563331668781 -0.576130753100757 "ERBB2 MUT" "WH.4.023_IC_50" 0.669631307818535 0.906882709825482 0.879093854379979 0.401999847805451 0.912301084962464 1.5266065960325 0.976246258628819 0.99742775226181 -0.058795626510104 "EWS_FLI1 MUT" "Thapsigargin_IC_50" 0.426508665861964 0.81941696345643 -0.598488850533814 0.402077121360262 0.912301084962464 0.516491660058031 0.50367443120584 0.934628630075023 0.558679632805803 "FGFR2 MUT" "PHA.665752_IC_50" 0.841516385966722 0.959741495283223 0.158994377104376 0.402371162671498 0.912301084962464 -0.676793783551853 0.816224821311071 0.977383317127464 -0.23086792221824 "CCND2 MUT" "PF.562271_IC_50" 0.318191298580787 0.761267128904167 0.886402485319509 0.402386624577074 0.912301084962464 0.602251765883728 0.477330508911646 0.930304161706959 0.757179245678779 "SMARCA4 MUT" "JW.7.52.1_IC_50" 0.743781649060425 0.929570057037101 0.510190034013611 0.402449618445125 0.912301084962464 0.794443286992308 0.809523387537611 0.977383317127464 -0.655856542344635 "CDKN2A MUT" "Cytarabine_IC_50" 0.000240836807945323 0.0179737116921211 -0.631728636867572 0.402500739428727 0.912301084962464 -0.114338773027005 0.323645248467112 0.900918773778407 -0.179816964843815 "FGFR2 MUT" "Bryostatin.1_IC_50" 0.118770663104358 0.577025305814989 0.985674608638755 0.402524459550645 0.912301084962464 0.507009775608577 0.277150445673007 0.884414807088842 0.756700668781629 "SMO MUT" "Gemcitabine_IC_50" 0.247259360585563 0.714668105985286 -3.3196172904348 0.402529185059241 0.912301084962464 -1.60010293904989 0.0845062472665708 0.747749574262573 -4.61142510637087 "TET2 MUT" "CGP.60474_IC_50" 0.280533655018233 0.737882141891724 -1.16362189306028 0.402677193333879 0.912301084962464 -0.680138617863687 0.36724207808868 0.913948248824328 -1.15529931772352 "TP53 MUT" "GDC0941_IC_50" 0.282779884579721 0.739072441127871 0.187615713888048 0.402763141550167 0.912301084962464 0.122984741873423 0.525162303214728 0.940554660491705 0.11830904130792 "CDKN2C MUT" "A.443654_IC_50" 0.931377007238261 0.986689293492114 -0.0720303195402308 0.402840041634519 0.912301084962464 0.455660519266973 0.942944023477451 0.995314665488626 0.0742767818793999 "EWS_FLI1 MUT" "Imatinib_IC_50" 0.346264103497529 0.782020929432191 -0.402156183712123 0.402912325280561 0.912301084962464 -0.388110037592653 0.174088891708711 0.84578207413725 -0.702428076053391 "TP53 MUT" "CGP.082996_IC_50" 0.953016944165493 0.992561499112566 -0.0116838083416081 0.402984050692977 0.912301084962464 0.147788768294476 0.816594689459057 0.977383317127464 -0.0500776480005248 "NF2 MUT" "WZ.1.84_IC_50" 0.020480768191024 0.259102140034878 -1.24347307692307 0.403005936168225 0.912301084962464 -0.382595075938389 0.770538244930652 0.969901216545994 -0.163691839789479 "BRCA1 MUT" "SB.216763_IC_50" 0.521161653871463 0.852853629635611 -0.468554187866933 0.403048190518375 0.912301084962464 -0.590853534019028 0.486403502539314 0.933639405738697 -0.488792719158651 "BCR_ABL MUT" "Vorinostat_IC_50" 0.254435448495336 0.719864738658005 -0.723671764822122 0.403093059046584 0.912301084962464 -0.494575728765527 0.560781074885742 0.949294892873838 0.346942731180255 "STK11 MUT" "Obatoclax.Mesylate_IC_50" 0.0985199395390223 0.536152212572481 0.792442725135629 0.403673476592542 0.913381947928246 0.294027201212112 0.287556027133487 0.888563331668781 0.521086807652823 "TSC1 MUT" "Elesclomol_IC_50" 0.303286362126938 0.753001448713821 1.58773954269448 0.40389853244003 0.913469460796646 1.07053176141756 0.351308756147504 0.910675149838292 1.35618255948898 "PIK3CA MUT" "GDC.0449_IC_50" 0.107951774224729 0.552948315127282 0.286768952991456 0.404311244030908 0.913469460796646 0.134281878382218 0.0876127375560818 0.755326311453013 0.332110390942915 "CDK6 MUT" "A.443654_IC_50" 0.643825925211626 0.896446680008675 0.54403865984073 0.404326108580913 0.913469460796646 -0.635487747384745 0.539850946844513 0.944569766818715 0.901216831815533 "IDH1 MUT" "Lenalidomide_IC_50" 0.320787519891603 0.762015213745527 0.746313377609104 0.40434784921287 0.913469460796646 0.54712529229506 0.376174326856812 0.914419412871569 0.641871092662551 "FGFR2 MUT" "CI.1040_IC_50" 0.358069406115246 0.786601117838604 1.16384093320613 0.404414169902657 0.913469460796646 0.952178063634715 0.195076100157467 0.851001889249827 -2.03982050434462 "MLL_AFF1 MUT" "GW843682X_IC_50" 0.105253806741196 0.548889640439555 -2.7966548305085 0.404473197789669 0.913469460796646 -0.757276590604247 0.111719332488355 0.797376436030023 -2.85634462493975 "FLT3 MUT" "ABT.888_IC_50" 0.465444389076131 0.83020920252764 -0.446704594147596 0.404558780748494 0.913469460796646 0.435055549478036 0.69123938215483 0.961100601384891 0.228427591922836 "MDM2 MUT" "A.770041_IC_50" 0.976620122285075 0.996276778834563 -0.0338016335616442 0.404600981508441 0.913469460796646 0.781743956548713 0.84450384057512 0.983349844199673 0.215104412523702 "CDKN2C MUT" "WZ.1.84_IC_50" 0.488703528781304 0.841958671689735 0.47828443678161 0.404891055111618 0.913469460796646 0.479097207273405 0.594759332009063 0.949294892873838 0.42426056915813 "MYCN MUT" "PD.0325901_IC_50" 0.732881757407011 0.928342145572949 0.170893669900061 0.404935497534124 0.913469460796646 -0.406605439143287 0.000130180043536092 0.0428195913571866 -2.02140357924945 "TP53 MUT" "Bicalutamide_IC_50" 0.558024726073278 0.86900908342163 0.0319767821184061 0.40496013615579 0.913469460796646 0.0449937963675176 0.261840896118448 0.877052916121269 0.0619338763544081 "RUNX1 MUT" "AZD6244_IC_50" 0.495467928584871 0.843282996121548 0.884208851239653 0.405054671049314 0.913469460796646 0.978570980168955 0.485690546667075 0.933639405738697 0.800932116960067 "CDK4 MUT" "ATRA_IC_50" 0.0538320355112728 0.413924075649882 1.06010473837209 0.405263424079417 0.913469460796646 0.361380204778925 0.0903361703943262 0.764118629741502 0.856034481761139 "VHL MUT" "Bortezomib_IC_50" 0.120068252532784 0.578267977626713 -2.02698416951082 0.405805092085549 0.913469460796646 -0.888475320554591 0.527675276379291 0.942617761067065 -0.815299885452185 "TP53 MUT" "Obatoclax.Mesylate_IC_50" 0.699214574391882 0.914968665673257 -0.0783179552288901 0.405845818973281 0.913469460796646 -0.129052901123424 0.310982152235421 0.898149383211927 -0.212581401648495 "KRAS MUT" "Elesclomol_IC_50" 0.00261985586846683 0.0792783302091417 0.769052435587164 0.405946953589906 0.913469460796646 0.188210410150356 0.0677268000026955 0.719539038493615 0.513765422777497 "EWS_FLI1 MUT" "VX.702_IC_50" 0.801588917281736 0.9507092914502 0.102007904575893 0.406019702069671 0.913469460796646 0.290915943563814 0.0381577034225539 0.645472009508728 0.903049988311971 "CCND1 MUT" "Roscovitine_IC_50" 0.251725589232108 0.717470497840808 0.61616170212766 0.406236404625043 0.913469460796646 0.402387774165136 0.304541440332659 0.895767221521364 0.653950924855712 "MLLT3 MUT" "NU.7441_IC_50" 0.332177479343933 0.773078667204787 -0.342108434002871 0.406271219945811 0.913469460796646 -0.256462972031986 0.325142286370143 0.900918773778407 -0.352983782363164 "MSH6 MUT" "JW.7.52.1_IC_50" 0.776400383667982 0.941591338606299 -0.384593950511942 0.406280047638471 0.913469460796646 0.681273387777536 0.76438125951054 0.969901216545994 -0.409476074764808 "KRAS MUT" "NVP.TAE684_IC_50" 0.107962209033972 0.552948315127282 -0.854492305446557 0.40634979233419 0.913469460796646 -0.383717109884084 0.129053098399777 0.820170087278083 -0.879974404917319 "APC MUT" "SL.0101.1_IC_50" 0.799295275434314 0.949963513555487 0.0581868897903994 0.406354861899255 0.913469460796646 -0.171633134937585 0.931801742194347 0.994235539701634 -0.0229124010382953 "FLCN MUT" "BIBW2992_IC_50" 0.302263374250284 0.752409982102741 0.981480923809529 0.406365364087902 0.913469460796646 0.755877270033255 0.90644938543319 0.988917021334873 -0.145672929674504 "FLT3 MUT" "Nilotinib_IC_50" 0.885372253596402 0.974449243426767 -0.136758897972116 0.406438351403247 0.913469460796646 0.642775108084249 0.381709291671803 0.915134825237766 0.749347603834623 "EWS_FLI1 MUT" "CGP.60474_IC_50" 0.249314189765216 0.71580012538195 0.657681971291854 0.406470931477921 0.913469460796646 0.384563079798062 0.935511415367197 0.994729228933513 -0.0518845409207549 "KDM5C MUT" "Cisplatin_IC_50" 0.188013051428453 0.663245512002727 -1.54526712903225 0.406493250943175 0.913469460796646 -0.848603706797397 0.132160604172332 0.824786416167871 -1.67894429501775 "MYCN MUT" "GDC.0449_IC_50" 0.707065466855782 0.917109451021791 0.107321833175754 0.406639529174723 0.913469460796646 0.217419936106309 0.983462621267401 0.998011368051263 0.0068982124755406 "NOTCH1 MUT" "Pyrimethamine_IC_50" 0.00313792588074331 0.0893202555989786 -2.00894241228071 0.406647022219634 0.913469460796646 -0.504441106820086 0.0680049567932717 0.719539038493615 -1.44120859634194 "NF2 MUT" "Vinblastine_IC_50" 0.960618806468676 0.99365707033384 -0.0196434450693666 0.406709009841168 0.913469460796646 0.238979761010051 0.659182501799655 0.958313128388245 0.176012789111819 "HRAS MUT" "GDC.0449_IC_50" 0.205358380650204 0.678240155654318 0.634957594033712 0.406797851306242 0.913469460796646 0.371849457261791 0.210857785338856 0.855272470862467 0.621488455831955 "CDH1 MUT" "ABT.888_IC_50" 0.541248473463685 0.861616652986104 -0.230075118497108 0.407023484941236 0.913633453407124 -0.267152765898961 0.23129078984856 0.869273594856142 -0.453151195755874 "EP300 MUT" "Gefitinib_IC_50" 0.744168477794714 0.92992264686856 -0.306779009505699 0.407112817872318 0.913633453407124 -0.704025437827106 0.55447038216418 0.948071221654821 -0.497703113723458 "APC MUT" "CMK_IC_50" 0.413398468342663 0.812881891750406 -0.429020368740028 0.407179507779011 0.913633453407124 -0.402042215228423 0.0781855972346289 0.741811190933953 -1.11845053221367 "PDGFRA MUT" "Vorinostat_IC_50" 0.424009027214344 0.818258185721553 0.45467317227723 0.40737005958227 0.913693351311079 0.359513413956435 0.841945851690793 0.982408776002613 0.105051715747434 "CDKN2C MUT" "BMS.509744_IC_50" 0.768097051250584 0.938562178337429 -0.210649931271479 0.407540408008257 0.913693351311079 -0.438984375389717 0.768227162647837 0.969901216545994 -0.251274405621297 "KDR MUT" "NSC.87877_IC_50" 0.299259264771237 0.750344870252218 -0.672319689119167 0.407678389036314 0.913693351311079 -0.5271295499773 0.401599993033581 0.916589616820582 -0.556999184375051 "MLLT3 MUT" "Cytarabine_IC_50" 0.425488244221455 0.819381892124907 -0.369321053250771 0.407721258532561 0.913693351311079 -0.291008707912096 0.623401586730487 0.950496524771391 -0.22081320376536 "MSH2 MUT" "Roscovitine_IC_50" 0.230663491450393 0.70328674741747 0.903216306620213 0.407818705777146 0.913693351311079 0.55371712817532 0.245710837651372 0.875707386589409 0.886637068081701 "MDM2 MUT" "FTI.277_IC_50" 0.50730637430384 0.847796212975596 -0.233008517482518 0.407992866447549 0.913693351311079 -0.264447602721 0.820917320879986 0.977383317127464 -0.0752725464442491 "RB1 MUT" "Sorafenib_IC_50" 0.913331146239903 0.983681869279028 -0.0322972175645246 0.408246830390196 0.913693351311079 -0.240214607771741 0.193294452405455 0.851001889249827 -0.468151302850321 "RUNX1 MUT" "EHT.1864_IC_50" 0.461387578629789 0.828966839128293 0.539523266219236 0.408345871632599 0.913693351311079 0.599182289975924 0.6112111907494 0.949930222127033 0.358765665988554 "BRAF MUT" "Cyclopamine_IC_50" 0.150758529949987 0.625297340409797 0.502989205741627 0.408444280576946 0.913693351311079 0.290458005097964 0.566127502647952 0.949294892873838 0.259192838963909 "MSH6 MUT" "PD.173074_IC_50" 0.0741796647159721 0.479604504293387 -1.05462239501311 0.408485227768506 0.913693351311079 -0.417646563942921 0.169395421897242 0.84067330207935 -0.742039494966417 "CDK4 MUT" "BMS.754807_IC_50" 0.219186049311579 0.692453909775927 -1.00642270342707 0.40857917947 0.913693351311079 -0.56674566860204 0.244196189387687 0.875707386589409 -0.99298285244197 "MYCN MUT" "Embelin_IC_50" 0.115744126833208 0.569171423258979 0.511934694793533 0.408614673048313 0.913693351311079 0.218481882800274 0.2757510058562 0.883780956691668 -0.40731399177711 "KDM5C MUT" "MS.275_IC_50" 0.589104063995628 0.876506729771444 -0.687433960045655 0.408630669208264 0.913693351311079 -0.874944235630394 0.617397651903544 0.950247055931602 -0.655893669644455 "SMO MUT" "IPA.3_IC_50" 0.210494723300867 0.684261946425694 -1.82967793739131 0.408646547844568 0.913693351311079 -1.00973836964976 0.038016152715297 0.645472009508728 -2.80112613965709 "CDKN2a(p14) MUT" "Bryostatin.1_IC_50" 0.210080026928698 0.684261946425694 -0.137049251442746 0.409092794726421 0.913733251404163 0.0891691296987399 0.302527146446826 0.894167310052 0.120223139481657 "NOTCH1 MUT" "BX.795_IC_50" 0.151719487384712 0.625830613280407 -0.730835300411532 0.409293262249141 0.913733251404163 -0.335470052289472 0.641212699540421 0.955103296458244 -0.22547476359602 "SETD2 MUT" "PD.0332991_IC_50" 0.408756038797638 0.810304102803978 1.15330117319585 0.409649212793609 0.913733251404163 0.925026198606083 0.328464139170256 0.902810042912437 1.27740072421061 "MET MUT" "Etoposide_IC_50" 0.582925514593631 0.876506729771444 -0.409345843655466 0.409657385706768 0.913733251404163 -0.40019893273992 0.290631996610796 0.891022884087089 -0.745017559056935 "FGFR3 MUT" "GSK.650394_IC_50" 0.748319152841482 0.9321790832252 -0.386517053426246 0.409786760020193 0.913733251404163 0.641627058989817 0.782259565032376 0.973465634570267 -0.330495467596287 "SETD2 MUT" "OSI.906_IC_50" 0.910527689901219 0.98207389045576 0.162243276521741 0.409801316710926 0.913733251404163 -1.13489444278556 0.980486116749557 0.997827228172038 -0.0355018110154743 "HRAS MUT" "CI.1040_IC_50" 0.394330828324277 0.803222955584382 -0.62519414294872 0.40980210193901 0.913733251404163 -0.542070269561705 0.957621429340206 0.99641548698706 0.0343890151608547 "STK11 MUT" "FTI.277_IC_50" 0.489001557096684 0.841958671689735 -0.158907139784948 0.409916023930884 0.913733251404163 -0.17259860723257 0.786163548918786 0.974870348210561 0.0629595757178811 "SMARCA4 MUT" "PAC.1_IC_50" 0.159078577488744 0.635813162321124 0.739328049148734 0.410053608739071 0.913733251404163 0.360247550264509 0.800263972135106 0.976360691959787 0.144059783886343 "BRCA1 MUT" "Cytarabine_IC_50" 0.87964576167074 0.972384118670381 0.150777830476194 0.410054224920316 0.913733251404163 -0.619526535622128 0.865675880444352 0.987077901072027 -0.155346453900902 "NOTCH1 MUT" "Camptothecin_IC_50" 0.00486478877777396 0.119019804780745 -1.70750427434122 0.410110788079627 0.913733251404163 -0.330691580086908 0.669662255770493 0.959230524020512 -0.248967558499743 "TP53 MUT" "ATRA_IC_50" 0.600256647743474 0.880698848449586 0.0835229043831162 0.410187303580119 0.913733251404163 0.107834207152715 0.535045145762831 0.943443271455699 -0.0930014555431819 "KDM5C MUT" "Vinorelbine_IC_50" 0.291909055645821 0.746611418788718 -1.0702131747405 0.410218995080258 0.913733251404163 -0.614260483894464 0.303511825401563 0.894622967627816 -1.02323971384207 "CDKN2A MUT" "Obatoclax.Mesylate_IC_50" 0.063738313410781 0.452847969120917 -0.358739459833147 0.410596887171514 0.913733251404163 0.123090906666632 0.612895585230945 0.949930222127033 0.107639069698031 "HRAS MUT" "NSC.87877_IC_50" 0.328521077800188 0.769814166739703 0.491084818024259 0.410741875726118 0.913733251404163 0.408142730624991 0.206887331652997 0.853446327418758 0.644055868149653 "TP53 MUT" "AZD8055_IC_50" 0.13300530127821 0.599873282011872 0.201306583920396 0.411025430108797 0.913733251404163 0.0902787876712949 0.579578286327977 0.949294892873838 0.0773225089383361 "MYC MUT" "VX.680_IC_50" 0.899821846266056 0.979208162809563 -0.0704776188725488 0.411206893725304 0.913733251404163 -0.306087853635922 0.643387017641643 0.955972780483685 -0.28395686468302 "KRAS MUT" "FTI.277_IC_50" 0.947518980343778 0.990899019819731 0.00864165458536572 0.411343433128089 0.913733251404163 0.104147069933978 0.741841203717507 0.96672489654949 0.0470162445098561 "CCND1 MUT" "TW.37_IC_50" 0.69295664899188 0.913066921534475 -0.107652859278163 0.411516882783387 0.913733251404163 -0.205136867965389 0.390682995141944 0.915926348152589 -0.242264833635778 "NF1 MUT" "AZD.2281_IC_50" 0.125936004284244 0.586978030371663 0.510092911189012 0.411526553903764 0.913733251404163 0.208126419493594 0.126377851803789 0.817150972850516 0.476406773544954 "IDH1 MUT" "Etoposide_IC_50" 0.21652864589281 0.689181240712449 -2.14256455862071 0.411648422030498 0.913733251404163 -0.923104701459981 0.340006073577695 0.907051943807165 -1.57690628849937 "FGFR3 MUT" "CHIR.99021_IC_50" 0.700487683869534 0.915410639012359 0.319448583765107 0.411674982562163 0.913733251404163 0.645967875252737 0.726272720214909 0.965402608571648 0.279743115053144 "PIK3CA MUT" "MS.275_IC_50" 0.407729089792499 0.809352267869285 0.514890147572286 0.411697290394401 0.913733251404163 0.424224386821588 0.388186866813921 0.915926348152589 0.611154351882983 "FGFR3 MUT" "WH.4.023_IC_50" 0.712906292237054 0.919646314953749 -0.926996034013608 0.411708137514307 0.913733251404163 1.79056276758848 0.600340957415808 0.949657634568742 -1.23462551060435 "SETD2 MUT" "Sorafenib_IC_50" 0.269858861326978 0.732686196100548 1.44696763050847 0.411875352620041 0.913733251404163 1.03874221298677 0.293185331467694 0.894167310052 1.43522247389178 "BCR_ABL MUT" "Metformin_IC_50" 0.495938022996561 0.843759690082846 -0.492047900763356 0.411944975293002 0.913733251404163 0.671012982448426 0.391645507100346 0.915926348152589 0.625097984877295 "MLH1 MUT" "AG.014699_IC_50" 0.816901305139526 0.955165737441734 -0.136840156108599 0.412115423559348 0.913733251404163 -0.427689294204288 0.559746078052944 0.949294892873838 -0.317201208467709 "SETD2 MUT" "IPA.3_IC_50" 0.0951416846963678 0.527890690029858 2.4372119756522 0.41237144889731 0.913733251404163 1.01259661680144 0.186475860921821 0.851001889249827 1.79515047670748 "MAP2K4 MUT" "PF.4708671_IC_50" 0.502904929900731 0.846691693355145 -0.251684223744289 0.412495538637627 0.913733251404163 -0.303777109163318 0.877136568645924 0.987838063957761 -0.0626318424466514 "MS-HL MUT" "Bleomycin_IC_50" 0.0354147835511048 0.347105523744792 -0.888469886454419 0.412771058612016 0.913733251404163 -0.286023577142833 0.0550768054912955 0.697305726351784 -0.869638429498239 "FLCN MUT" "WH.4.023_IC_50" 0.297410810436067 0.748266144511455 2.14532730147895 0.412968464003708 0.913733251404163 1.46354426942956 0.845633334928501 0.98378870157398 0.661149402702644 "NF1 MUT" "EHT.1864_IC_50" 0.54474359044049 0.862633715268747 0.160683744131457 0.413161683688413 0.913733251404163 0.216573406308234 0.500624652709897 0.934042323734638 0.185315014415845 "GNAS MUT" "DMOG_IC_50" 0.173879701845744 0.651401757469953 0.775780979020979 0.413241164590365 0.913733251404163 0.420002519421008 0.541827806940442 0.945765861891114 0.331076442813821 "EP300 MUT" "AKT.inhibitor.VIII_IC_50" 0.627308335663976 0.891518522789462 0.450004264248695 0.413506716244645 0.913733251404163 0.651343096218423 0.482437926009051 0.931217392063982 0.632515281248217 "ERBB2 MUT" "BI.2536_IC_50" 0.35894958067992 0.786601117838604 -1.20653271428571 0.413562338144026 0.913733251404163 -0.651686101875278 0.456404879577299 0.925809648901546 -1.04184685032755 "FGFR3 MUT" "CMK_IC_50" 0.921912181432803 0.986140039233073 -0.118788761904762 0.413695229158832 0.913733251404163 0.901957591866107 0.722795605721081 0.965402608571648 -0.440928890436983 "AKT2 MUT" "Pazopanib_IC_50" 0.218806233204767 0.692453909775927 -0.88055213759399 0.413833708616758 0.913733251404163 -0.497129742060721 0.264796256941892 0.877052916121269 -0.73818468352174 "FAM123B MUT" "Thapsigargin_IC_50" 0.941412929669447 0.989446598697723 0.0949931493007011 0.413996765535333 0.913733251404163 -0.805614264065192 0.773354127010011 0.971176188062204 -0.366714821016416 "ALK MUT" "Mitomycin.C_IC_50" 0.615421497780395 0.885815598771911 0.788435932173919 0.414001350265386 0.913733251404163 1.00308604827142 0.976621071523988 0.99742775226181 0.0630026060838986 "MYC MUT" "MK.2206_IC_50" 0.569974766103175 0.872389778906173 0.167367202460851 0.414065944358791 0.913733251404163 -0.193228326569851 0.169086216366444 0.84067330207935 0.412933963007516 "SMAD4 MUT" "Pyrimethamine_IC_50" 0.991728886524508 0.998361396647489 0.00921890147783191 0.414117327977932 0.913733251404163 0.635172537176086 0.971018318519877 0.99742775226181 -0.0344285087928283 "SMO MUT" "SL.0101.1_IC_50" 0.479973260485773 0.836304203722611 0.608870921305178 0.414253934812434 0.913733251404163 0.610506011261867 0.65767393403834 0.958313128388245 0.365616400015496 "KDM5C MUT" "PF.4708671_IC_50" 0.251429448652897 0.717470497840808 0.780070749063682 0.414313482178722 0.913733251404163 0.549189394624171 0.325771910554761 0.900918773778407 0.675783447029211 "ALK MUT" "Cyclopamine_IC_50" 0.294501341489864 0.747036827777118 0.898514776632299 0.414362117150247 0.913733251404163 0.643937281132933 0.38078557820527 0.915134825237766 0.924492862585404 "BRCA1 MUT" "Vorinostat_IC_50" 0.593867488071236 0.878468193610776 0.338776160079049 0.414370823004294 0.913733251404163 -0.396854357852543 0.909270241022817 0.98973268911921 0.0657534117070308 "KIT MUT" "RDEA119_IC_50" 0.883054815896758 0.973927829424842 0.172721834990062 0.414494204698073 0.913733251404163 0.866385485388472 0.597354639787788 0.949294892873838 0.535107107656173 "SMAD4 MUT" "RDEA119_IC_50" 0.165436308007865 0.64339386611283 -0.664866190871372 0.414536239292466 0.913733251404163 -0.3633170489476 0.566760561349332 0.949294892873838 -0.24976852420357 "EZH2 MUT" "RO.3306_IC_50" 0.457062405817832 0.828966839128293 -0.548543941176472 0.414834835133595 0.913733251404163 -0.569815357023268 0.324814416587093 0.900918773778407 -0.723782219685127 "EWS_FLI1 MUT" "IPA.3_IC_50" 0.127150731437045 0.587259147140593 -0.822970274021361 0.41511194705113 0.913733251404163 0.396745747174393 0.818995429701336 0.977383317127464 0.131185188556323 "KDR MUT" "Midostaurin_IC_50" 0.112287318810263 0.563432092377384 -1.71568561139896 0.415322280240183 0.913733251404163 -0.677188038315965 0.473206461510254 0.929276781658587 -0.712323209580727 "PTEN MUT" "Obatoclax.Mesylate_IC_50" 0.543860901907462 0.862633715268747 0.164187139789574 0.41535520223155 0.913733251404163 0.165517803779759 0.949398786519947 0.995668765770473 0.0178342111825986 "CDK6 MUT" "BMS.509744_IC_50" 0.0894906072162622 0.514272513671442 1.70277200680272 0.415382934249281 0.913733251404163 0.611087614266798 0.0811749732945044 0.741811190933953 2.1008602066438 "AKT2 MUT" "KIN001.135_IC_50" 0.324493276256439 0.765831726397406 0.542818518518513 0.415400030024177 0.913733251404163 0.435867547832552 0.231979796322311 0.869962136993019 0.620260527490367 "MSH6 MUT" "ABT.263_IC_50" 0.768707743527045 0.938868331695358 -0.262710378608922 0.415402799336572 0.913733251404163 0.655338385502032 0.555616470686281 0.948071221654821 0.453846296836627 "BRCA1 MUT" "Roscovitine_IC_50" 0.45764561124174 0.828966839128293 0.880994482758615 0.415729753681002 0.913733251404163 0.850908876502712 0.50209651155484 0.934042323734638 0.806158548845613 "MS-HL MUT" "CGP.082996_IC_50" 0.636818705545692 0.895268363706423 0.132697576573881 0.415811792617036 0.913733251404163 0.194104169943239 0.412321744408651 0.921714070263062 0.257716305503686 "PTEN MUT" "WH.4.023_IC_50" 0.680787215563513 0.909596174888715 0.230337625 0.416126015198413 0.913733251404163 0.402467450465157 0.19592587390851 0.851001889249827 0.729225888962478 "KIT MUT" "BI.2536_IC_50" 0.493236723206634 0.843282996121548 -1.10214570508474 0.416164572685968 0.913733251404163 0.80600920576366 0.686555348525778 0.961100601384891 -0.678659975913371 "TP53 MUT" "Embelin_IC_50" 0.648743631675806 0.898481490800108 -0.0573897206336416 0.416291727000105 0.913733251404163 -0.0853114460720129 0.479318110257338 0.930304161706959 -0.0951570790653545 "BRAF MUT" "Imatinib_IC_50" 0.651410195030668 0.899243470992269 0.142189946899623 0.416595321292139 0.913733251404163 0.274543152428928 0.411618191709086 0.921714070263062 0.352489408375606 "CTNNB1 MUT" "Roscovitine_IC_50" 0.663842930217277 0.903538553756266 0.29980396270396 0.416646016122274 0.913733251404163 0.490415149587811 0.996719597021905 0.999545005862799 0.0031566925780206 "FLT3 MUT" "Lapatinib_IC_50" 0.522353556194683 0.853303159804623 0.661091337946947 0.416840216319542 0.913733251404163 0.73406923188042 0.949265774114024 0.995668765770473 0.0580985422722238 "EP300 MUT" "Camptothecin_IC_50" 0.240511494643566 0.711340033600749 -1.52607437325727 0.416964835081801 0.913733251404163 -0.668545530105573 0.139970417891702 0.831473272394224 -1.68295660753885 "FAM123B MUT" "CHIR.99021_IC_50" 0.459548519021817 0.828966839128293 0.476502270363947 0.416987289160381 0.913733251404163 0.495089642291716 0.578630248847171 0.949294892873838 0.350106806091317 "MYC MUT" "Cytarabine_IC_50" 0.743212705258565 0.929570057037101 0.105680760095961 0.417027276920694 0.913733251404163 -0.199140601252152 0.853042741933868 0.984631915507353 -0.0578671854438077 "KDM6A MUT" "Embelin_IC_50" 0.565773600998771 0.872332526123279 0.182745072798905 0.417101367326707 0.913733251404163 0.207364029929415 0.325164548881147 0.900918773778407 0.327909415182977 "EP300 MUT" "PF.02341066_IC_50" 0.627005832682378 0.89123540333742 0.560659533557042 0.41715903667867 0.913733251404163 0.863082530694819 0.454878452709027 0.925809648901546 0.845572724972969 "CDK4 MUT" "TW.37_IC_50" 0.732023454410859 0.928176068595523 0.147771798173515 0.417179519718802 0.913733251404163 -0.31777242498784 0.525092422435489 0.940554660491705 0.275177679261136 "CCND1 MUT" "NVP.BEZ235_IC_50" 0.337769670782357 0.77552545145246 0.30331850208333 0.417340274470228 0.913733251404163 0.186446875650446 0.510692240468778 0.938693162701913 0.21358941112315 "MS-HL MUT" "PF.02341066_IC_50" 0.709040981137338 0.918331622728434 0.104182444149721 0.417426053941116 0.913733251404163 0.209860273585209 0.168757313109826 0.84067330207935 0.424426619671816 "CCND3 MUT" "Bosutinib_IC_50" 0.198542815032586 0.674012093366938 1.63577615428575 0.417437996399143 0.913733251404163 0.846344701074763 0.124901598956235 0.817150972850516 1.7967980532141 "CDKN2A MUT" "Lenalidomide_IC_50" 0.814086509562278 0.953913887475092 0.021785319060097 0.417513414603956 0.913733251404163 0.0687106817816678 0.536184812342073 0.943443271455699 0.0624656260367451 "MET MUT" "PLX4720_IC_50" 0.873594044406839 0.970705450102207 0.0878256832358675 0.417589017808235 0.913733251404163 -0.398193335488906 0.932550618817094 0.994235539701634 -0.0423096530475863 "FLCN MUT" "XMD8.85_IC_50" 0.812108611780272 0.953508273561687 0.251145463917525 0.417690167389656 0.913733251404163 -0.736223814720954 0.611939819751769 0.949930222127033 -0.929837100562534 "PIK3CA MUT" "Cytarabine_IC_50" 0.230558819952821 0.70328674741747 0.347141622520564 0.417720527130492 0.913733251404163 0.180260472459805 0.525737742481691 0.94058760898064 0.187191748233271 "FBXW7 MUT" "Bryostatin.1_IC_50" 0.518904474364031 0.852599738673405 -0.176740312366911 0.417791970123516 0.913733251404163 -0.209791976500222 0.225926456784738 0.86643108387559 -0.329603226443235 "KDM6A MUT" "GSK269962A_IC_50" 0.735168194928125 0.928872455997232 0.221775086673888 0.417971129208551 0.913733251404163 0.496856431235931 0.681905588677833 0.961100601384891 -0.293857918862054 "PIK3R1 MUT" "Vinorelbine_IC_50" 0.0418946910031745 0.368354819675836 1.56375457267084 0.417973788525988 0.913733251404163 0.457233215351944 0.0655617692237889 0.711992560878964 1.38575996299076 "KDM6A MUT" "NVP.TAE684_IC_50" 0.0776882182155725 0.486980385654137 -1.1100261390845 0.417992629088337 0.913733251404163 -0.420403150602128 0.119134390146065 0.80678720253446 -1.06949236953127 "CDK4 MUT" "Cisplatin_IC_50" 0.063230800453724 0.450893824743909 0.981784341040464 0.418038958002358 0.913733251404163 0.371274549303719 0.0255338030079122 0.578483940084869 1.18412083505114 "PTEN MUT" "PAC.1_IC_50" 0.611854418690841 0.88496040166963 0.102871010449546 0.418118217854295 0.913733251404163 0.140574199122286 0.935962334156914 0.994729228933513 -0.0170078701196998 "AKT2 MUT" "AZD6482_IC_50" 0.124684073345711 0.585263877052461 -1.14689052645964 0.41818398412184 0.913733251404163 -0.509836145955395 0.0899579972573621 0.76232535652923 -1.25154108260622 "KDR MUT" "CCT007093_IC_50" 0.376548304104825 0.795051761241315 -0.518093288590606 0.41827287276005 0.913733251404163 -0.47649114012645 0.357102767954768 0.91161229252998 -0.551997676701803 "FGFR2 MUT" "SB590885_IC_50" 0.330304112176888 0.771549400379523 1.25481434210524 0.418283939354379 0.913733251404163 0.87962334744546 0.659222740064999 0.958313128388245 0.70152351370459 "SOCS1 MUT" "BIRB.0796_IC_50" 0.5172301851129 0.852353345422823 0.557791142857154 0.418293106930851 0.913733251404163 0.667084217818678 0.399591844118899 0.916480913435499 0.716546600571234 "CTNNB1 MUT" "BIRB.0796_IC_50" 0.369659688865212 0.789549710632984 -0.30623765339719 0.418311415056229 0.913733251404163 -0.264961617647467 0.267856439278501 0.877052916121269 -0.408392790651066 "FGFR3 MUT" "AZ628_IC_50" 0.93407933560681 0.987517726433927 0.158351602040815 0.41841956493053 0.913733251404163 1.15077781042341 0.614656214698023 0.950059945073224 -0.834038402615209 "HRAS MUT" "PF.4708671_IC_50" 0.31923876664476 0.761311064402907 -0.526037223476293 0.418489609503191 0.913733251404163 -0.425417934866964 0.230602126554379 0.868523106840304 -0.641615398863435 "MLL_AFF1 MUT" "PHA.665752_IC_50" 0.246333292915828 0.714668105985286 -1.12586802013421 0.418526377651381 0.913733251404163 -0.799477588506944 0.218993432316109 0.861955336129779 -1.22665761884069 "BRCA2 MUT" "Vinorelbine_IC_50" 0.291835518213541 0.746611418788718 0.875474418402788 0.418579124426992 0.913733251404163 0.494519693086457 0.379616161703725 0.915134825237766 0.724129331463896 "NOTCH1 MUT" "DMOG_IC_50" 0.0663775984385173 0.458546662429304 -0.831833105123663 0.418726307606238 0.913733251404163 -0.339332351343501 0.596526085016558 0.949294892873838 -0.249766854139729 "CDKN2A MUT" "Gemcitabine_IC_50" 0.00797421633524695 0.156679237330372 -0.901931140436751 0.418825776958906 0.913733251404163 -0.193774072871617 0.89208321577262 0.988301482344111 -0.0495894498148883 "SMAD4 MUT" "Sunitinib_IC_50" 0.32870224665314 0.770035518999351 -0.880080030153236 0.418850045311591 0.913733251404163 -0.55710828948121 0.069853346594974 0.724728470922855 -1.50655991986996 "CDKN2a(p14) MUT" "ABT.888_IC_50" 0.639802211322821 0.895624997957207 0.0443248385377002 0.418851178838072 0.913733251404163 0.0671120123357653 0.791504579211833 0.975393509832241 0.0261445535895719 "ERBB2 MUT" "PF.562271_IC_50" 0.102045402767758 0.542024654294532 0.61699399302446 0.418915020273049 0.913733251404163 0.256274644586322 0.343760501826715 0.907180409180092 0.372288494777528 "EZH2 MUT" "Erlotinib_IC_50" 0.18820484462924 0.663245512002727 1.31155163017032 0.418924118607636 0.913733251404163 0.722999622905985 0.403492995320299 0.91712184556463 0.987063442196402 "MLLT3 MUT" "JNJ.26854165_IC_50" 0.616185568498698 0.885815598771911 -0.14535851851852 0.419013154921045 0.913733251404163 -0.218208036633026 0.80881609143269 0.977383317127464 -0.0680122342231848 "CTNNB1 MUT" "Etoposide_IC_50" 0.358976705973428 0.786601117838604 -0.587518147442675 0.41905566203891 0.913733251404163 0.336688280116348 0.58189039577792 0.949294892873838 -0.37526939573711 "EZH2 MUT" "AZD8055_IC_50" 0.703363581966464 0.915500829364901 0.271332615308155 0.419109695045149 0.913733251404163 0.445169079492689 0.871907259872481 0.987643979884169 0.110934899048726 "MS-HL MUT" "AZ628_IC_50" 0.351065778128892 0.784966682190403 0.436891743982049 0.419256496637585 0.913733251404163 0.28626190320578 0.0539755264001483 0.697305726351784 0.870135972877841 "PIK3R1 MUT" "Z.LLNle.CHO_IC_50" 0.112315065164199 0.563432092377384 1.29748283505155 0.419372485166929 0.913733251404163 0.606612842925557 0.145597567920884 0.831473272394224 1.14752263094385 "PDGFRA MUT" "GDC0941_IC_50" 0.501727645239977 0.846422209719112 -0.548338022727271 0.419420996031574 0.913733251404163 -0.530691755056722 0.736663941635616 0.96672489654949 -0.277213252613356 "IDH1 MUT" "ZM.447439_IC_50" 0.259367727812298 0.723189643810247 -1.27635185742186 0.419547303277536 0.913733251404163 -0.722160890059984 0.253438921381659 0.875707386589409 -1.22836567844335 "APC MUT" "GDC0941_IC_50" 0.000164734183151275 0.0138511142031137 1.30069459925036 0.419570859511952 0.913733251404163 0.239321989348262 0.0473853414316221 0.673636396626734 0.852215073204974 "EZH2 MUT" "Axitinib_IC_50" 0.585388536612121 0.876506729771444 0.435874068702294 0.419780999094039 0.913733251404163 0.541599983037746 0.910807283236861 0.990141873133243 0.0784195462799712 "KDR MUT" "AS601245_IC_50" 0.204274297794775 0.676168482562578 -1.32278859233448 0.419799445480815 0.913733251404163 -0.672772271454931 0.425501089522758 0.922428741067589 -0.829767017356728 "EZH2 MUT" "AG.014699_IC_50" 0.440808126798545 0.824500931653809 0.556536601351356 0.419837200340203 0.913733251404163 0.509256097092316 0.792041670358993 0.975393509832241 0.176145596697293 "TP53 MUT" "JW.7.52.1_IC_50" 0.718670250733115 0.92132587844031 -0.117362136175045 0.419985822764672 0.913733251404163 0.166750443261131 0.661426672504698 0.958689538788368 -0.159480806862665 "NF1 MUT" "Tipifarnib_IC_50" 0.155375582838359 0.630721638230745 0.676266669125726 0.420030095384893 0.913733251404163 -0.257440076334517 0.616188382712544 0.950247055931602 0.254264334890326 "PIK3R1 MUT" "JW.7.52.1_IC_50" 0.273208941064938 0.734000646544246 1.32810188356163 0.42027449415066 0.913733251404163 -0.590822727079834 0.28269214114494 0.8879937007725 1.31009575808046 "CDKN2C MUT" "AP.24534_IC_50" 0.252388542344322 0.717470497840808 1.00998111888112 0.420376990477725 0.913733251404163 0.642859341529952 0.200851476168772 0.851001889249827 1.26615235461029 "CTNNB1 MUT" "Cytarabine_IC_50" 0.140483105562181 0.611283910091978 -0.820398519528912 0.420479431197154 0.913733251404163 -0.340513381062326 0.0807809458399523 0.741811190933953 -0.982034537215183 "FGFR3 MUT" "FTI.277_IC_50" 0.319593402976052 0.761442367303009 -0.634570248704652 0.420596318211993 0.913733251404163 -0.467563347123366 0.262302253564485 0.877052916121269 -0.676211779599737 "AKT2 MUT" "Tipifarnib_IC_50" 0.446680692021181 0.825892730562573 -0.647667616040104 0.420639752972722 0.913733251404163 0.455067202424522 0.460384625635462 0.928307449490652 -0.625804909411119 "STK11 MUT" "AZD6482_IC_50" 0.31700863353106 0.761258739353268 0.409999951612908 0.420644750670549 0.913733251404163 0.279019581327073 0.283965310196719 0.8879937007725 0.456317908309724 "SMAD4 MUT" "Vinblastine_IC_50" 0.398359644531906 0.80588428316352 0.297975959569132 0.420690738430402 0.913733251404163 0.210147797350614 0.604377043158056 0.949657634568742 -0.182249945593 "KIT MUT" "BMS.536924_IC_50" 0.436753869873318 0.823808548892323 -1.36318695932203 0.420702090416802 0.913733251404163 1.07937555855831 0.748555648607448 0.968780465757047 0.537601710234005 "SMO MUT" "FTI.277_IC_50" 0.625242502007824 0.890724841246629 0.381194010344834 0.420805533182206 0.913734459704443 0.569542522105806 0.67392826474495 0.960256725054738 0.310403909940888 "FBXW7 MUT" "CEP.701_IC_50" 0.607599774071944 0.884017916530788 -0.202134252964425 0.420978482495449 0.913886556597918 -0.233205234800375 0.939078452898196 0.994831655017307 -0.0289083990543642 "MLL_AFF1 MUT" "GDC0941_IC_50" 0.387133144501459 0.799423849645855 -1.11254357494867 0.421236881490902 0.91422403336283 -0.851838271970729 0.801132560136023 0.976360691959787 -0.327420454933095 "MDM2 MUT" "Elesclomol_IC_50" 0.909425675389156 0.981529929795606 0.0791122524084783 0.421496805712894 0.914564654663136 -0.464543042676305 0.806843488718584 0.977383317127464 0.159762572787905 "MS-HL MUT" "Cyclopamine_IC_50" 0.64390491192628 0.896446680008675 0.120138731727837 0.421604927510306 0.914575808798003 0.195016923550064 0.318433243632862 0.900918773778407 0.290029895330637 "CDK4 MUT" "GSK269962A_IC_50" 0.374660300177865 0.79430845688222 -1.45520579830509 0.421929410564472 0.914896833791711 -1.24107126253375 0.705221488802838 0.962630898212352 -0.620906756565815 "RB1 MUT" "Camptothecin_IC_50" 0.766131545570697 0.937321153907337 -0.0930052820850721 0.422130144533834 0.914896833791711 -0.162745033749489 0.706068626086324 0.962630898212352 -0.115126370902976 "MET MUT" "AZD8055_IC_50" 0.0721393333559112 0.474889173046706 0.814032695774643 0.422131311148719 0.914896833791711 0.283721881006914 0.200620437901066 0.851001889249827 0.558492824087943 "BRCA2 MUT" "BIRB.0796_IC_50" 0.787512767946276 0.946449577332088 -0.147272988505748 0.42223659135292 0.914896833791711 -0.423311785496554 0.57430075272987 0.949294892873838 -0.3064582970923 "MSH6 MUT" "KU.55933_IC_50" 0.36002218844544 0.786601117838604 0.516124126984131 0.422269300703816 0.914896833791711 0.402178873115066 0.565300448633917 0.949294892873838 0.318929265401715 "STK11 MUT" "Temsirolimus_IC_50" 0.118341035224416 0.575883141823581 0.774789057557823 0.422585787645332 0.914896833791711 0.30456156715315 0.143932215835457 0.831473272394224 0.735257660071655 "KDR MUT" "CCT018159_IC_50" 0.533990825265657 0.858279561609675 0.509560564454609 0.42259378369925 0.914896833791711 0.614275536399193 0.621292798434545 0.950496524771391 0.412741927303092 "EWS_FLI1 MUT" "PF.02341066_IC_50" 0.288416493524497 0.743664502093737 0.529939273670966 0.422629329142299 0.914896833791711 0.40722223300835 0.903287021583856 0.988746233284632 0.0683420185290362 "JAK2 MUT" "Temsirolimus_IC_50" 0.827035363772305 0.957737129307562 -0.189605649151614 0.422680070830694 0.914896833791711 -0.531903678681051 0.713500120145579 0.962630898212352 -0.329217049513946 "KDM6A MUT" "Dasatinib_IC_50" 0.0941109106506085 0.525329351029575 -1.67852249999999 0.422929312257384 0.915213260759704 -0.665965207674652 0.0483786361308332 0.676839988046433 -1.87286435084653 "MYCL1 MUT" "GNF.2_IC_50" 0.783878853491162 0.944974629816073 -0.141819447126438 0.423204107938902 0.915584819148693 -0.400815338010886 0.16094408087258 0.839927262232576 -0.76674529287707 "JAK2 MUT" "Thapsigargin_IC_50" 0.704418530306683 0.915500829364901 0.415111514285722 0.423686485815237 0.916190040756293 -0.667474167191778 0.777044169774629 0.972337708041191 -0.327475940814039 "SMAD4 MUT" "SB.216763_IC_50" 0.576409979387772 0.873455460479685 -0.160703106405586 0.423690180991566 0.916190040756293 -0.229094432311872 0.173958893741509 0.84578207413725 -0.400778889981437 "CCND1 MUT" "Rapamycin_IC_50" 0.683045335397004 0.910146380144154 0.362869440972224 0.423882717624579 0.916198082576441 0.616059760674333 0.610237306940673 0.949930222127033 0.533634078414384 "PTEN MUT" "BIRB.0796_IC_50" 0.287348022694187 0.742453942209604 0.162127683312452 0.423900227598986 0.916198082576441 0.119250227146095 0.353119264413443 0.911252930312559 0.152617211785869 "FLCN MUT" "Docetaxel_IC_50" 0.278539311385367 0.736660995953974 -1.1334201521599 0.424364840959083 0.916842198447663 -0.626921698811939 0.208611039686608 0.853446327418758 -2.18105839408383 "FGFR3 MUT" "IPA.3_IC_50" 0.237359121503183 0.709759716521808 -1.41103899070846 0.424435716961029 0.916842198447663 -0.800692698419343 0.116064822744421 0.802355750183445 -1.73796291169295 "CDKN2A MUT" "AZD.2281_IC_50" 0.751369517947968 0.932940664991998 -0.0421578228353779 0.424507951809119 0.916842198447663 0.0836842714197278 0.654876776955033 0.958313128388245 -0.05924232615495 "BRAF MUT" "Cisplatin_IC_50" 0.734175734224561 0.928593402067957 0.0802065658611434 0.424693406108971 0.916916762651026 -0.180160410104416 0.977227422419087 0.99742775226181 0.00770587051879809 "MYC MUT" "AP.24534_IC_50" 0.087803780232494 0.511142337432447 0.739964138306865 0.424748965380737 0.916916762651026 0.315092391137168 0.311926025824502 0.898149383211927 0.435874992142475 "MSH6 MUT" "Thapsigargin_IC_50" 0.828358957391869 0.958015830101332 0.222119430579966 0.425003744639975 0.917163487970433 0.622352498515429 0.718849203586406 0.964721180904622 0.356165047171127 "STK11 MUT" "AZD6244_IC_50" 0.203776475889628 0.675781408528279 0.665773560053985 0.425164911621192 0.917163487970433 0.381324885937677 0.0344903692970096 0.618827479917328 1.06283226808767 "STK11 MUT" "SB590885_IC_50" 0.0773204935967283 0.486043076549996 0.700074479286536 0.425173075101258 0.917163487970433 0.265641289307185 0.204589215320268 0.853446327418758 0.473433631426421 "MET MUT" "MK.2206_IC_50" 0.227420614817393 0.699592130305946 0.688085985324943 0.425418198243665 0.917442590439842 0.364504536989215 0.424007508187421 0.922428741067589 0.442883162529269 "EP300 MUT" "GW.441756_IC_50" 0.666184145327331 0.904922207808508 -0.303795143852973 0.425577062248319 0.917442590439842 -0.550949466399155 0.6738635886103 0.960256725054738 -0.292207854811852 "AKT2 MUT" "FH535_IC_50" 0.170685021560474 0.649721929411943 -0.827615541604015 0.425612371648705 0.917442590439842 -0.411889470653044 0.408527617547408 0.920903133902018 -0.484020535220818 "FBXW7 MUT" "GDC.0449_IC_50" 0.926141432954832 0.98643792569589 -0.024678063161738 0.425733492496662 0.917480986863105 0.189367326909179 0.599011231609096 0.949657634568742 0.146567486394346 "PTEN MUT" "JNK.9L_IC_50" 0.710862658083345 0.919312211985394 0.0591868907697665 0.426028741904896 0.917638631789577 0.101504209262373 0.992239415708666 0.999469155159075 -0.00167715602184497 "MET MUT" "Sorafenib_IC_50" 0.690532403424714 0.912932803156675 -0.522575284745767 0.42613185501007 0.917638631789577 -0.987272083023223 0.77917418841786 0.972337708041191 -0.379667016330715 "RUNX1 MUT" "X17.AAG_IC_50" 0.333008915891985 0.773185226006147 -1.2297250349873 0.426199655268787 0.917638631789577 -0.885939690634268 0.327411696712432 0.902810042912437 -1.0832569326377 "MSH6 MUT" "BIBW2992_IC_50" 0.139362108932368 0.608499182243643 -1.06559672003284 0.426268854218728 0.917638631789577 -0.54936665940675 0.0454931042484442 0.668076316205317 -1.32331406604221 "SMAD4 MUT" "ZM.447439_IC_50" 0.729771743252212 0.927541495579058 0.111112264659521 0.426323273816439 0.917638631789577 -0.209313390369098 0.291520279945261 0.89121914154694 -0.34129886261578 "EP300 MUT" "RO.3306_IC_50" 0.815235097500618 0.954403229752569 0.198877312459235 0.426544608178083 0.917770668985735 0.64807374053466 0.70493556238876 0.962630898212352 0.319997084167652 "KRAS MUT" "JNK.9L_IC_50" 0.318602399528326 0.761267128904167 -0.163138283707316 0.426591298454353 0.917770668985735 -0.106109777172025 0.375575027772374 0.914419412871569 -0.164673591556951 "MDM2 MUT" "JNK.Inhibitor.VIII_IC_50" 0.19647903527168 0.672783946439227 0.470786595744681 0.426881758537153 0.917878043958021 0.276843284104972 0.225457737738145 0.86643108387559 0.442522898126869 "TP53 MUT" "Bryostatin.1_IC_50" 0.430873770295216 0.820918238409269 0.0873739347429197 0.426939179380533 0.917878043958021 0.0863572601812121 0.575339664492917 0.949294892873838 0.0640992712905258 "RUNX1 MUT" "X681640_IC_50" 0.352171754496163 0.784969887597353 -0.878358979674814 0.427227011808876 0.917878043958021 -0.638230897921559 0.340078748700435 0.907051943807165 -0.838170498976874 "FLCN MUT" "PHA.665752_IC_50" 0.688738752386607 0.911985814812204 -0.318480370370369 0.427318242102642 0.917878043958021 -0.626206913382312 0.958848705869844 0.99641548698706 0.0741444871784542 "TET2 MUT" "GSK.650394_IC_50" 0.441884846339303 0.825166478070376 -0.926189643437851 0.427354850348073 0.917878043958021 -0.625308196163556 0.401210776636561 0.916589616820582 -1.23332531086437 "NOTCH1 MUT" "MS.275_IC_50" 0.0196813120591977 0.252951855857793 -1.50101770347468 0.427441504693127 0.917878043958021 -0.447120104555249 0.0323514632449278 0.618827479917328 -1.64875542557148 "BRCA2 MUT" "Doxorubicin_IC_50" 0.254437047027078 0.719864738658005 0.911504320490372 0.427555461993003 0.917878043958021 0.396409678867081 0.486215559263999 0.933639405738697 0.535545028618772 "CDH1 MUT" "AZD8055_IC_50" 0.840105650833127 0.959424448728358 -0.10206951528056 0.427580910182937 0.917878043958021 -0.316572096072603 0.261755369871178 0.877052916121269 -0.590105173692539 "TP53 MUT" "X17.AAG_IC_50" 0.345354271976994 0.781026557022583 0.19068643884614 0.427734436956105 0.917878043958021 0.147642642373419 0.653353152429887 0.958313128388245 0.0858027909199465 "MSH2 MUT" "Pazopanib_IC_50" 0.546622974755906 0.863032646899058 -0.431880408270681 0.427750030462593 0.917878043958021 0.487001090455773 0.24590767825708 0.875707386589409 -0.766191014553041 "BRAF MUT" "PF.4708671_IC_50" 0.0317485159294836 0.329006499381264 0.368181263434441 0.427778090749043 0.917878043958021 0.14459810059465 0.195608500583288 0.851001889249827 0.265657530922223 "FLCN MUT" "A.443654_IC_50" 0.283736367415489 0.739564104351618 1.26033845506257 0.427908048350887 0.91793511531503 0.604885152230633 0.662814963362628 0.959019173936706 -0.924726424927486 "NRAS MUT" "CCT007093_IC_50" 0.135999486956098 0.60335156031289 0.299067691095351 0.428201656869383 0.918270063065023 0.16586823856639 0.590303598154053 0.949294892873838 0.127105600936847 "IDH1 MUT" "SB590885_IC_50" 0.571045220913978 0.872389778906173 0.730449969635619 0.428641286475829 0.918270063065023 0.848797999406081 0.481881157580069 0.931143535039242 0.798656127507594 "ERBB2 MUT" "KIN001.135_IC_50" 0.535441204092109 0.859514121743984 -0.217143537414966 0.428827331957836 0.918270063065023 -0.278353164194256 0.8167705100262 0.977383317127464 -0.079602497943915 "NF1 MUT" "NSC.87877_IC_50" 0.497929894669587 0.844997935313146 -0.16487279220779 0.428923503342129 0.918270063065023 -0.190411466267946 0.255899081527679 0.875707386589409 -0.303333861710574 "TET2 MUT" "LFM.A13_IC_50" 0.360478890152489 0.786781278801733 0.585225319396043 0.429003985819189 0.918270063065023 0.482064490441241 0.396254196919747 0.916441021574029 0.662388117396699 "ALK MUT" "Elesclomol_IC_50" 0.0482313550363713 0.39044578066473 -3.04258641555976 0.429128934995807 0.918270063065023 -1.01421322158351 0.0242296006756877 0.569786836641336 -3.29617564545059 "MLL_AFF1 MUT" "NVP.TAE684_IC_50" 0.664389393516911 0.903589924015879 -0.755585859060393 0.429166931446304 0.918270063065023 1.15515479566677 0.627149417237665 0.952105511848497 -0.851790114586997 "TP53 MUT" "Dasatinib_IC_50" 0.0855817745658977 0.503679085433888 0.81286719344588 0.429484590509909 0.918270063065023 0.332078192912807 0.33787692444653 0.906230588643738 0.435020101249183 "PDGFRA MUT" "PD.0325901_IC_50" 0.343167161732453 0.779805203811004 0.956739005976094 0.429620924942949 0.918270063065023 0.750877598149785 0.271405033592794 0.88032104330475 0.987385852430143 "PDGFRA MUT" "Bleomycin_IC_50" 0.960762668951321 0.99365707033384 0.0728830069930041 0.429631669774362 0.918270063065023 0.954095157920148 0.766485713881974 0.969901216545994 0.43085806830384 "FLCN MUT" "BMS.754807_IC_50" 0.779643349988834 0.942683810925913 0.289299340909092 0.429740283345995 0.918270063065023 -0.680472659362097 0.840787883543706 0.982150602679453 -0.26187002828629 "GNAS MUT" "PF.562271_IC_50" 0.161843384557189 0.637610023074489 0.684273340909089 0.429819246373373 0.918270063065023 0.315020530355133 0.242149821873018 0.875707386589409 0.566173425271385 "CDK4 MUT" "Vorinostat_IC_50" 0.0261733542420686 0.300179404454845 0.944325040585498 0.429857394884317 0.918270063065023 0.25666960368911 0.0874078553801082 0.755326311453013 0.697643627718286 "EWS_FLI1 MUT" "JNJ.26854165_IC_50" 0.00971626165459763 0.174676355778303 -0.826004979664025 0.429929919509178 0.918270063065023 -0.264330251259818 0.835550319348544 0.981626636221501 -0.0815889038773257 "FLCN MUT" "Bryostatin.1_IC_50" 0.23860283119161 0.710855542080976 0.666910882867132 0.430022625683919 0.918270063065023 0.42074271698923 0.946560018181309 0.995668765770473 0.0466103427589687 "EWS_FLI1 MUT" "JW.7.52.1_IC_50" 0.29670513087717 0.747966539904914 0.861747097902108 0.430086008174054 0.918270063065023 -0.432929439758815 0.800866250563705 0.976360691959787 0.243680699698749 "FLCN MUT" "OSI.906_IC_50" 0.821197496946799 0.956293356389236 -0.206910073426572 0.430131280382902 0.918270063065023 -0.681661678851013 0.257843821433959 0.877052916121269 -1.33660699457014 "BRAF MUT" "Temsirolimus_IC_50" 0.224340903172502 0.696139064632428 0.39446473525125 0.430212911694998 0.918270063065023 0.215581405790378 0.265130155672312 0.877052916121269 0.409678177632089 "MAP2K4 MUT" "Thapsigargin_IC_50" 0.825317464602771 0.957177484110155 0.178167023731585 0.430354080765451 0.918270063065023 0.485161185258858 0.762776556692324 0.969901216545994 0.260310136071409 "PIK3CA MUT" "EHT.1864_IC_50" 0.224654628764328 0.696147159126308 -0.238794532931556 0.430356663392693 0.918270063065023 -0.155725310717906 0.613795188436809 0.950059945073224 -0.105673940622335 "NRAS MUT" "Paclitaxel_IC_50" 0.591194701472344 0.877253169412525 -0.309869529090908 0.430419293698386 0.918270063065023 0.208295486745312 0.627546559192975 0.952105511848497 -0.313190959330564 "MLH1 MUT" "VX.680_IC_50" 0.104043945045954 0.546754009439714 1.52845350347221 0.430424037964535 0.918270063065023 0.488360286034642 0.0517229074291961 0.690213288728522 1.91452185856649 "APC MUT" "AZD.0530_IC_50" 0.327752455237216 0.769735904120651 -0.607435987689396 0.430442323222575 0.918270063065023 -0.436911712731957 0.308874086625739 0.89718581932126 -0.703281087750715 "TET2 MUT" "X17.AAG_IC_50" 0.146066740013552 0.619919550890177 1.84540712786265 0.430708636936482 0.91829119719719 0.892933041586281 0.349558512102085 0.909999728614578 1.28345963061275 "SMARCA4 MUT" "MK.2206_IC_50" 0.514122863654891 0.85130999259055 0.415180625260959 0.43073611657609 0.91829119719719 0.39830372467928 0.534343956448759 0.943443271455699 0.451498001923557 "GNAS MUT" "Bleomycin_IC_50" 0.163175095707861 0.638639513991862 1.46597325396825 0.430823955699843 0.91829119719719 0.674738573258666 0.30580695895835 0.896682870760742 1.0456122303719 "KRAS MUT" "AG.014699_IC_50" 0.00579711698673875 0.131763970791639 0.492219694317397 0.430865828028453 0.91829119719719 0.131711606271418 0.594538072347192 0.949294892873838 0.102579721419558 "FBXW7 MUT" "Etoposide_IC_50" 0.16382826724507 0.639542347869657 -0.740567291883108 0.431248296242105 0.918670084401715 -0.275017671082701 0.318352086733518 0.900918773778407 -0.522896802416051 "STK11 MUT" "BI.2536_IC_50" 0.816921953823561 0.955165737441734 0.23681290068493 0.43139372128985 0.918670084401715 0.478891763751802 0.791013614518761 0.975393509832241 0.320125606554712 "MS-HL MUT" "Obatoclax.Mesylate_IC_50" 0.0437153495046233 0.374825086237107 -0.594926166609614 0.431563742043992 0.918670084401715 -0.171774540034408 0.0702808792543253 0.727487375216157 -0.570654494714584 "GNAS MUT" "Nutlin.3a_IC_50" 0.125477105017653 0.586857535554275 1.01757943873517 0.431693987892574 0.918670084401715 0.477802703665459 0.273957559661777 0.882167181782537 0.702413221374086 "MYCL1 MUT" "BMS.754807_IC_50" 0.574500412670312 0.872620551543038 -0.412260481481485 0.431702357351885 0.918670084401715 -0.481220513404262 0.519628168279508 0.939635632721979 -0.506461431650022 "SMARCA4 MUT" "Lapatinib_IC_50" 0.79489185696421 0.948646027682356 0.268726862745099 0.431729675851789 0.918670084401715 0.703494862886946 0.298345205205607 0.894167310052 -1.61847307645468 "MYCL1 MUT" "Roscovitine_IC_50" 0.522981288644691 0.853786180965717 -0.440541958041954 0.431767698715545 0.918670084401715 -0.484750265852055 0.263580435019124 0.877052916121269 -0.802168490255356 "VHL MUT" "Sorafenib_IC_50" 0.544472326908674 0.862633715268747 -0.564319015358362 0.431917864256883 0.918769473644401 -0.703312474417578 0.342627403605429 0.907180409180092 -0.953730741792195 "KIT MUT" "WZ.1.84_IC_50" 0.488413517501911 0.84176216746254 -0.82330673469388 0.432113336324269 0.918965167599577 0.808974192254313 0.944536986320181 0.995333788087439 0.0792613519151218 "NF2 MUT" "Cytarabine_IC_50" 0.146810137862217 0.619919550890177 -0.640372777840267 0.432343694595561 0.919234941753215 -0.263059294479589 0.737718816125692 0.96672489654949 -0.146406426567263 "SMARCA4 MUT" "Salubrinal_IC_50" 0.829721179229904 0.958015830101332 -0.214651484018263 0.432761831397957 0.919888615381299 -0.645273994384772 0.416382901381847 0.922398153848459 -1.38357221626421 "KIT MUT" "Mitomycin.C_IC_50" 0.279987671322897 0.737882141891724 -1.07477240034966 0.432858295651216 0.919888615381299 -0.614164720505973 0.131544377086096 0.824721122422311 -1.46065276673211 "NF1 MUT" "AG.014699_IC_50" 0.436253279017825 0.823808548892323 0.239593061176473 0.433256816360959 0.920183770814256 0.212838958617036 0.236355466181644 0.871856821645725 0.358547930005577 "MYCL1 MUT" "NVP.TAE684_IC_50" 0.494113688554554 0.843282996121548 0.692025217687075 0.433259988803102 0.920183770814256 0.65960608921886 0.566837188822404 0.949294892873838 -0.605184462161484 "JAK2 MUT" "BMS.708163_IC_50" 0.506442909605874 0.847796212975596 0.3071259145437 0.433379085716026 0.920183770814256 0.367441451334857 0.889811968956126 0.988301482344111 -0.070537254445862 "AKT2 MUT" "AP.24534_IC_50" 0.819181277524113 0.95524539465489 0.2405998757764 0.433736765837614 0.920183770814256 0.740538291395941 0.886959631365942 0.988301482344111 -0.142397684145141 "KDM6A MUT" "GDC.0449_IC_50" 0.0276774775087524 0.308798590144762 -0.703285933993396 0.43380886321465 0.920183770814256 -0.224737977671433 0.199156759236994 0.851001889249827 -0.421859704239407 "MLH1 MUT" "Cyclopamine_IC_50" 0.200097516694698 0.674012093366938 0.678046503496498 0.433815803885885 0.920183770814256 0.384880576602719 0.0687500395784342 0.722654662887059 0.977625715421355 "MLLT3 MUT" "Obatoclax.Mesylate_IC_50" 0.920576045472424 0.986016435821543 -0.0510510310037689 0.433818496409135 0.920183770814256 0.292566684065262 0.758708054377033 0.969901216545994 0.157609498521137 "NF1 MUT" "Cyclopamine_IC_50" 0.671086783544249 0.906916702390321 0.17190357142857 0.433856777180557 0.920183770814256 -0.292694112901817 0.941938103400044 0.995314665488626 -0.0334754579607521 "MYCN MUT" "RO.3306_IC_50" 0.453905574224608 0.828966839128293 -0.245207364049065 0.433929696224536 0.920183770814256 -0.252503520475746 0.869682863500195 0.98753907730331 -0.0652326563686862 "STK11 MUT" "MK.2206_IC_50" 0.581899842844954 0.876233523356533 0.230031935222674 0.434122209584732 0.920372247152544 -0.26208032539755 0.317394880376824 0.900918773778407 0.438054550902065 "FLCN MUT" "JNJ.26854165_IC_50" 0.569461650760464 0.872389778906173 -0.375328419475658 0.434327766516911 0.920588280295153 -0.480933388749392 0.413894348858134 0.921714070263062 -0.623037896834933 "KIT MUT" "Pyrimethamine_IC_50" 0.76257354334365 0.936064732612588 0.498300033898305 0.434911902459941 0.921470583318712 1.12444910195499 0.792935059603584 0.975393509832241 0.438179688569741 "NOTCH1 MUT" "AP.24534_IC_50" 0.0755167814202135 0.480779116570693 -1.24543045914309 0.435013427836255 0.921470583318712 -0.507175101661147 0.566564920654922 0.949294892873838 -0.416755147629893 "CDH1 MUT" "NSC.87877_IC_50" 0.788016945065989 0.946449577332088 -0.10111780104712 0.435192746416294 0.921470583318712 -0.292652030838667 0.659737244337995 0.958313128388245 -0.179918810092841 "SMO MUT" "BI.D1870_IC_50" 0.298066947087498 0.749047129904942 1.18579279809525 0.435292759435857 0.921470583318712 0.763896524291215 0.459248165900504 0.927632358897555 0.796691130416906 "NRAS MUT" "ZM.447439_IC_50" 0.283686445350909 0.739564104351618 -0.30816017079317 0.435401356647128 0.921470583318712 0.184935447700487 0.628984649889374 0.952431828758317 -0.150482122547613 "EWS_FLI1 MUT" "JNK.Inhibitor.VIII_IC_50" 0.128130959164598 0.588664235316545 -0.470375332776391 0.435446601808376 0.921470583318712 -0.243270986131963 0.618990572187711 0.950394619652337 -0.179774796267417 "PDGFRA MUT" "GSK.650394_IC_50" 0.230680587234218 0.70328674741747 -1.11973786713287 0.435565474923825 0.921470583318712 -0.47013820000594 0.258000397880665 0.877052916121269 -1.06929905075672 "FGFR3 MUT" "BI.2536_IC_50" 0.400232033783915 0.806000156924025 -1.35286907796611 0.43567310984637 0.921470583318712 0.743056118922431 0.497767663238909 0.934042323734638 -1.13237943874284 "KDM6A MUT" "Bleomycin_IC_50" 0.996183497845223 0.998977896287767 -0.00350715741692681 0.435677849268694 0.921470583318712 0.468668402609586 0.778241493294234 0.972337708041191 0.210702133470368 "FAM123B MUT" "RDEA119_IC_50" 0.484948345039822 0.83972091053812 -0.94571849603173 0.435949333965716 0.921626631193766 -0.953810888603639 0.492527659541141 0.933639405738697 -0.800601219778092 "KDM6A MUT" "GNF.2_IC_50" 0.116644516755696 0.571973892266404 -0.504592939285711 0.436126905034905 0.921626631193766 -0.240209606047832 0.14187198398377 0.831473272394224 -0.522888032197231 "NOTCH1 MUT" "Epothilone.B_IC_50" 0.327249712896487 0.769477114660932 -0.57954529467469 0.436248709393864 0.921626631193766 0.273413676478923 0.306492710138463 0.896682870760742 -0.650608240333404 "CDKN2A MUT" "GDC0941_IC_50" 0.172601279264155 0.650961807890931 -0.224963126157484 0.436255098536158 0.921626631193766 0.107742122229767 0.728220114499743 0.965402608571648 -0.0648469867743226 "CDH1 MUT" "Vinblastine_IC_50" 0.149539266551559 0.62466549367193 0.91633600863722 0.436270518284156 0.921626631193766 0.362836654133293 0.511753155978649 0.939086342216131 0.421271691194903 "NF1 MUT" "Epothilone.B_IC_50" 0.0135096658973761 0.210490075148416 1.22367076895308 0.43637428039295 0.921626631193766 0.22188823438399 0.184855636469929 0.851001889249827 0.694686343967781 "MSH2 MUT" "Paclitaxel_IC_50" 0.589910431161893 0.876506729771444 0.578809017182134 0.436571416829011 0.921823764350559 0.366151876182028 0.76408769074009 0.969901216545994 0.328719095864491 "NOTCH1 MUT" "QS11_IC_50" 0.162262869376472 0.637610023074489 -0.694295616310163 0.436852755397519 0.922198554952546 0.29261531054885 0.612029956388071 0.949930222127033 -0.271339496979441 "NOTCH1 MUT" "JW.7.52.1_IC_50" 0.275657747810233 0.734728829022412 -0.863342596491232 0.436988884463111 0.92226670221409 0.392628175172785 0.207909249759943 0.853446327418758 -1.16759156560772 "KDM5C MUT" "AICAR_IC_50" 0.45176268836866 0.828509891052426 -0.914048355899432 0.437186781592277 0.922332514191321 -0.850326978414252 0.492872855941071 0.933639405738697 -0.793614122985634 "PTEN MUT" "VX.680_IC_50" 0.945902295690609 0.990164814713378 -0.028131448924731 0.437227776685673 0.922332514191321 -0.21303385418214 0.89151532554731 0.988301482344111 0.06306761459801 "KDR MUT" "LFM.A13_IC_50" 0.686595008031626 0.911730003936733 0.258292160278743 0.437360986280015 0.922355676575141 0.466888813591717 0.389602780204276 0.915926348152589 0.553890815202556 "BCR_ABL MUT" "Vinorelbine_IC_50" 0.827141513544533 0.957737129307562 0.221841929065742 0.437695877511705 0.922355676575141 -0.698141122129457 0.405037948632165 0.917872421995983 0.847004736955104 "MYCL1 MUT" "QS11_IC_50" 0.574713196698621 0.872620551543038 -0.351002534391537 0.437725715643336 0.922355676575141 -0.356735597113851 0.545389292817994 0.946853280734584 -0.403184717626151 "AKT2 MUT" "Cisplatin_IC_50" 0.238496372296629 0.710855542080976 0.802004887826637 0.437787954146095 0.922355676575141 0.45817503179425 0.253207522754725 0.875707386589409 0.750660891041961 "CCND3 MUT" "SB.216763_IC_50" 0.387512290255679 0.799604240186033 0.890643879142299 0.437872844213467 0.922355676575141 0.77243853495737 0.427689594273995 0.922428741067589 0.785028421517549 "MLH1 MUT" "CCT007093_IC_50" 0.429836777788767 0.820918238409269 0.328203378378375 0.437887397123028 0.922355676575141 0.323627379750013 0.537187941172838 0.943443271455699 0.258068882980618 "CDKN2a(p14) MUT" "Lenalidomide_IC_50" 0.709365362294975 0.918499371481488 0.0354043260059949 0.438015222341149 0.922355676575141 0.067210785349214 0.347162268165741 0.909751579693109 0.0955257481259894 "PDGFRA MUT" "Bryostatin.1_IC_50" 0.700705047180049 0.915410639012359 0.217633666083917 0.43806961420943 0.922355676575141 0.413646980724123 0.208049961114862 0.853446327418758 0.691776255748828 "CDKN2C MUT" "Bicalutamide_IC_50" 0.675203420338842 0.908552538148308 0.0829130511463845 0.438865250179242 0.92271126587128 0.146324164071783 0.771316274140932 0.969901216545994 0.0643194563805158 "CDH1 MUT" "NVP.BEZ235_IC_50" 0.262809098868821 0.724847082936025 0.615454915492963 0.438901462719743 0.92271126587128 0.311755515448198 0.926703162880587 0.994186152404781 0.0516383138136827 "FLCN MUT" "EHT.1864_IC_50" 0.292667413527908 0.747036827777118 -0.770543847874719 0.438963410170004 0.92271126587128 -0.562896875330264 0.620381557648158 0.950496524771391 0.431048479653307 "FAM123B MUT" "ABT.888_IC_50" 0.250693645198491 0.717470497840808 0.609153539196936 0.439032613369568 0.92271126587128 0.346603345491365 0.2314412283841 0.869471044534344 0.602738580851937 "FLT3 MUT" "JW.7.52.1_IC_50" 0.320543750480774 0.762015213745527 -1.54938037414968 0.43922237687279 0.92271126587128 0.737667543615511 0.451970633422251 0.925809648901546 -1.19884431140555 "PDGFRA MUT" "SB.216763_IC_50" 0.573308968923221 0.872620551543038 -0.368270372549019 0.43924930341172 0.92271126587128 -0.487806697236889 0.372291066856233 0.913948248824328 -0.571418093888016 "MS-HL MUT" "BMS.708163_IC_50" 0.602368733884624 0.880745626033854 0.0983905756564803 0.439280965271138 0.92271126587128 0.147963239413139 0.531833350435575 0.94320946427311 0.130989118660812 "KIT MUT" "PF.4708671_IC_50" 0.513527074175606 0.85130999259055 -0.385478040540543 0.439338056256601 0.92271126587128 -0.452951918116923 0.565082460345657 0.949294892873838 -0.347023360712197 "STK11 MUT" "BX.795_IC_50" 0.195942967841581 0.671674313682969 0.450187028001533 0.439388297302102 0.92271126587128 0.208399162628082 0.606453253698567 0.949657634568742 0.169976617510781 "MLL_AFF1 MUT" "Etoposide_IC_50" 0.110116981601498 0.558827950630228 -2.76870123103449 0.439588455960005 0.92271126587128 0.887122395166499 0.392566756965093 0.915926348152589 -1.41347697626474 "RUNX1 MUT" "MK.2206_IC_50" 0.812717489407046 0.953718819162788 0.244973654269968 0.439593839001235 0.92271126587128 -0.635769336629797 0.993513280592608 0.999469155159075 -0.00812627249404304 "FBXW7 MUT" "AS601245_IC_50" 0.400566000830738 0.806019304668694 -0.329073930712527 0.439776587420012 0.92271126587128 -0.242429552441362 0.548669018394152 0.947060194029534 -0.241485524794226 "ERBB2 MUT" "VX.702_IC_50" 0.834233566094499 0.959122768755193 -0.0773202808274591 0.43991629559281 0.92271126587128 -0.240309608161603 0.109580888324251 0.795960407011784 -0.585662457234726 "FGFR2 MUT" "ATRA_IC_50" 0.506439553112722 0.847796212975596 0.811797337786278 0.439977447343589 0.92271126587128 0.748522454860308 0.21646154294369 0.860576337437605 1.86698939659938 "GNAS MUT" "BX.795_IC_50" 0.597100801326202 0.879232253518807 0.300944475409835 0.439982809614033 0.92271126587128 -0.337969312077633 0.479483343674571 0.930304161706959 -0.354055193533716 "NRAS MUT" "AG.014699_IC_50" 0.990218523230002 0.998036562927507 -0.00349988765725372 0.43998952248174 0.92271126587128 -0.202031836952773 0.997631924717105 0.99968575015939 -0.000911418554876014 "TET2 MUT" "PD.173074_IC_50" 0.210473217479305 0.684261946425694 -1.04378878016962 0.440004752951793 0.92271126587128 0.558236111640507 0.452495982425007 0.925809648901546 0.708702708620286 "BRCA1 MUT" "PHA.665752_IC_50" 0.482133922404788 0.838752471082649 0.683091711409392 0.440226752609566 0.922958873920103 0.744998703656195 0.316059809703843 0.900294798053993 1.01047229879865 "PTEN MUT" "GNF.2_IC_50" 0.695577279604969 0.913718445479852 0.0773512856182796 0.440381734066961 0.923065891019279 0.14791016100309 0.215785996833012 0.860576337437605 0.268333449446871 "APC MUT" "PD.173074_IC_50" 0.0755734316780416 0.480779116570693 0.48089093663912 0.440619861305712 0.923111106702483 -0.187463342667406 0.545504214700232 0.946853280734584 0.184502465301159 "CTNNB1 MUT" "RO.3306_IC_50" 0.310360130699973 0.757046299071613 -0.435338665338645 0.440712223797965 0.923111106702483 -0.315833387924988 0.0145239157813883 0.489839878474164 -1.14605420749863 "HRAS MUT" "Cisplatin_IC_50" 0.166783234682085 0.646248650615878 -0.94047525876354 0.440715132577246 0.923111106702483 -0.45533796683923 0.260040263568495 0.877052916121269 -0.733884686491719 "PIK3R1 MUT" "CCT007093_IC_50" 0.583253541093452 0.876506729771444 0.211440212834572 0.44106601708508 0.923128487346665 0.297243825109812 0.490825258025387 0.933639405738697 0.268989742206239 "VHL MUT" "VX.680_IC_50" 0.65623220733044 0.901751651084414 0.527766422680416 0.441139706432403 0.923128487346665 -0.609400849299122 0.696299284771191 0.961100601384891 0.559029204969443 "TP53 MUT" "Axitinib_IC_50" 0.022965190474093 0.27673521926787 0.371726197290705 0.441187576881424 0.923128487346665 0.111168475430163 0.473446696511941 0.929276781658587 0.11083692130452 "MYC MUT" "AKT.inhibitor.VIII_IC_50" 0.619394325532034 0.887477435756715 0.124707582967219 0.441275092740668 0.923128487346665 -0.167914294844587 0.983081048003999 0.998011368051263 -0.00549715950351185 "MYCL1 MUT" "Cisplatin_IC_50" 0.723618130928988 0.923974852378165 -0.208892717370442 0.441374206128645 0.923128487346665 -0.393228546144512 0.737022144982037 0.96672489654949 -0.208193763749728 "RB1 MUT" "Shikonin_IC_50" 0.126831957909382 0.587206821914858 0.400063403847788 0.44156727950001 0.923128487346665 0.173961790127632 0.476668789604348 0.929855889225741 0.20772039841355 "NF2 MUT" "DMOG_IC_50" 0.261782573702196 0.724288808298587 -0.44620397249809 0.441857362073565 0.923128487346665 -0.277538198284379 0.785275673606601 0.974807190013589 -0.110181428108379 "CDKN2C MUT" "Nutlin.3a_IC_50" 0.158507196398724 0.63438594466745 0.936670150197618 0.441865574909457 0.923128487346665 0.469475340060784 0.0294704404954085 0.59799127175549 1.49711228767562 "STK11 MUT" "CGP.60474_IC_50" 0.437333030460817 0.823808548892323 -0.651280453608249 0.441963466020944 0.923128487346665 -0.481135764169024 0.708464427570435 0.962630898212352 -0.348108347760292 "KDR MUT" "OSI.906_IC_50" 0.525541289703963 0.854969048950887 0.74889129036004 0.441997894985245 0.923128487346665 0.8571089307282 0.574215794964426 0.949294892873838 0.672702475642219 "JAK2 MUT" "NU.7441_IC_50" 0.302285645326267 0.752409982102741 0.605784938369793 0.442058757824281 0.923128487346665 0.396070793642681 0.939294546032249 0.994831655017307 -0.0475873793192549 "ERBB2 MUT" "CCT018159_IC_50" 0.599896343555474 0.880698848449586 -0.188942688679246 0.442293237907703 0.923128487346665 -0.267913951670837 0.315831025752522 0.900294798053993 -0.389001980983453 "MYCL1 MUT" "PAC.1_IC_50" 0.463342042248951 0.829490249358073 -0.403719834215171 0.442447833934112 0.923128487346665 -0.35359379929867 0.416141924309678 0.922398153848459 -0.471356221451675 "NRAS MUT" "AS601245_IC_50" 0.52358558834869 0.854075976778526 -0.184083603649309 0.442483387351185 0.923128487346665 -0.181756015234315 0.617188087784511 0.950247055931602 -0.163033564684307 "AKT2 MUT" "Metformin_IC_50" 0.739749755906796 0.929570057037101 -0.196410536398466 0.442560490890064 0.923128487346665 -0.423187706762775 0.558109515601375 0.94928677421639 -0.342234351491862 "CCND1 MUT" "X17.AAG_IC_50" 0.226991519571109 0.699346740297147 -0.543020375936252 0.442562466177057 0.923128487346665 -0.305119931146918 0.89876710132396 0.988599284971277 -0.0542810248169135 "JAK2 MUT" "AZ628_IC_50" 0.176561159379677 0.655261034872926 2.11279512286688 0.442577881208519 0.923128487346665 0.887101565209368 0.174660998082166 0.84578207413725 2.26216032203269 "CTNNB1 MUT" "Axitinib_IC_50" 0.589698539652842 0.876506729771444 -0.269281142069168 0.442610092995441 0.923128487346665 -0.324277595521974 0.435964905267913 0.922569292988365 -0.373079129531805 "MAP2K4 MUT" "Imatinib_IC_50" 0.689157136132663 0.912131822055765 0.322789673423426 0.442794707035775 0.923128487346665 0.610871093984983 0.99729403186018 0.999545005862799 -0.00352211970408212 "IDH1 MUT" "Midostaurin_IC_50" 0.305396113388569 0.754233282259144 -1.35590467068967 0.44280231461511 0.923128487346665 -0.779962363734903 0.727780353352886 0.965402608571648 -0.421376107745646 "MYCL1 MUT" "GW.441756_IC_50" 0.775197894254185 0.941591338606299 -0.123752119001918 0.443012317886813 0.923211772053818 -0.324322488706161 0.921851788654361 0.993931766508607 0.04619094590213 "APC MUT" "KIN001.135_IC_50" 0.624958182854897 0.890724841246629 0.116689646464647 0.443050171432651 0.923211772053818 0.185764698647908 0.77932210129362 0.972337708041191 0.0751864753608813 "NF2 MUT" "Imatinib_IC_50" 0.280251975749572 0.737882141891724 -0.482585674740479 0.443441372928253 0.923470452440897 -0.344753604764174 0.807076638343863 0.977383317127464 -0.126501093500888 "CDKN2a(p14) MUT" "NSC.87877_IC_50" 0.90478503091878 0.980404570472143 0.0115701822799754 0.443691719075907 0.923470452440897 0.076321436557588 0.222762856912699 0.865601665610206 0.133705732476435 "FBXW7 MUT" "X681640_IC_50" 0.79457369252392 0.948646027682356 -0.0926163276955616 0.443750007345164 0.923470452440897 0.233713064545029 0.8564165431127 0.984631915507353 0.0647055333220967 "TET2 MUT" "AUY922_IC_50" 0.356340435520574 0.786601117838604 1.01062994715446 0.44375249109724 0.923470452440897 0.571535247702246 0.411332980831625 0.921714070263062 1.05399462596418 "MDM2 MUT" "X17.AAG_IC_50" 0.969055614091289 0.994856543446662 0.027184804642166 0.443846597887643 0.923470452440897 -0.472101166512156 0.726158045411206 0.965402608571648 0.21424587034592 "CDK6 MUT" "Z.LLNle.CHO_IC_50" 0.85965706000009 0.966322414954601 -0.186274017064847 0.444181189077581 0.923470452440897 -0.738376692744228 0.949252746660022 0.995668765770473 0.0798847158113082 "EWS_FLI1 MUT" "FTI.277_IC_50" 0.321499293767972 0.762412610935476 0.285649499118163 0.444209238897901 0.923470452440897 0.215384849325637 0.895059849243149 0.988301482344111 0.0411665374406463 "MS-HL MUT" "PD.0332991_IC_50" 0.809627998864449 0.952641225877339 0.065463908704137 0.444227549362085 0.923470452440897 0.166211775717798 0.300252935017421 0.894167310052 0.288724850367426 "BCR_ABL MUT" "RDEA119_IC_50" 0.0947698207514264 0.527350111587355 -1.95910733001991 0.444260663174346 0.923470452440897 -0.994107642969445 0.0175200616539908 0.513211661128791 -2.45564002217666 "SMARCA4 MUT" "Nutlin.3a_IC_50" 0.742825601660828 0.929570057037101 -0.195507011904763 0.444306964754364 0.923470452440897 -0.41491207551379 0.295933710286025 0.894167310052 -0.687612105842021 "CDKN2C MUT" "SB590885_IC_50" 0.247336734655175 0.714668105985286 0.749988698770495 0.444318122202449 0.923470452440897 0.417098091105791 0.02121495989635 0.544537742310648 1.39805768993163 "TP53 MUT" "FH535_IC_50" 0.725229724826809 0.924863965058017 0.0491782612296955 0.444739284772836 0.923544190053525 0.095336879278052 0.985931968362747 0.998124818853736 0.00254986908505889 "EWS_FLI1 MUT" "Rapamycin_IC_50" 0.465878565478148 0.830483247693985 0.675483985215477 0.444774813266726 0.923544190053525 0.664589925948441 0.791353572352862 0.975393509832241 0.285177215849212 "FGFR3 MUT" "OSI.906_IC_50" 0.264199287342228 0.726560302215652 -1.31665143321718 0.444931920671688 0.923544190053525 -0.850769249829958 0.22578883955181 0.86643108387559 -1.4303415305032 "CDKN2C MUT" "OSI.906_IC_50" 0.182824903187088 0.659821175430369 0.865502959435622 0.445114222855444 0.923544190053525 0.470731438710183 0.100478630211235 0.774133667469059 1.27850249252244 "MET MUT" "Pazopanib_IC_50" 0.425827880238404 0.819381892124907 -0.456673003051721 0.445149491861074 0.923544190053525 -0.373716203440317 0.143229216406853 0.831473272394224 -0.767743695894634 "NRAS MUT" "QS11_IC_50" 0.0823720932141735 0.497989489336334 -0.545195427859365 0.445286711972068 0.923544190053525 -0.181941506400271 0.207796866535647 0.853446327418758 -0.441335636945375 "CDK4 MUT" "Embelin_IC_50" 0.307906456205822 0.756423880316111 -0.519480004393677 0.445312235356209 0.923544190053525 -0.312215696751424 0.610639032899894 0.949930222127033 -0.272436870028111 "FLCN MUT" "PLX4720_IC_50" 0.176188313764291 0.654424263714207 1.28219820153552 0.445348135523114 0.923544190053525 0.642030765332124 0.375196157620865 0.914419412871569 1.0747111502974 "SMARCA4 MUT" "Obatoclax.Mesylate_IC_50" 0.283051721126965 0.739347745684876 0.75231231480887 0.445389110192277 0.923544190053525 0.390623946611003 0.261896801695921 0.877052916121269 0.847563911063472 "EGFR MUT" "GW.441756_IC_50" 0.124913897849868 0.58603292488361 0.397498658102766 0.445515020110786 0.923544190053525 0.194559144235635 0.0972390464611637 0.772625185318248 0.446187417634047 "KDM5C MUT" "Erlotinib_IC_50" 0.733128027874566 0.928405819984888 -0.340338880778592 0.445579146870818 0.923544190053525 -0.688672252149331 0.955386425997005 0.996100446818628 -0.0541511083359259 "ERBB2 MUT" "Bosutinib_IC_50" 0.0830744612775473 0.498552626562699 0.766855550980388 0.44560149244222 0.923544190053525 0.287128285213256 0.43827904969902 0.922796643048126 0.338947879555111 "MAP2K4 MUT" "TW.37_IC_50" 0.336249225683781 0.773835028063658 0.414774581735155 0.445786341330179 0.923628612223898 0.298257493737554 0.679086558554848 0.961100601384891 0.181725710663896 "JAK2 MUT" "Lapatinib_IC_50" 0.455058500864482 0.828966839128293 0.771862733564017 0.445867698580683 0.923628612223898 0.676248817534451 0.0929068731993846 0.768046723169691 1.87655273736868 "CCND1 MUT" "AZD6482_IC_50" 0.435349346977958 0.823150425912549 0.302214089489492 0.44596622325458 0.923628612223898 0.25150339923643 0.673893592570872 0.960256725054738 0.170774428754231 "HRAS MUT" "BMS.708163_IC_50" 0.703902488227241 0.915500829364901 -0.207445116853933 0.446201397656425 0.923628612223898 -0.42165084478115 0.581156900649343 0.949294892873838 -0.304258253573257 "CCND2 MUT" "GSK.650394_IC_50" 0.920787242524867 0.986016435821543 -0.119796960511029 0.446242448381215 0.923628612223898 -0.589458873042373 0.908345195803662 0.989534075687441 -0.168685877767922 "BRCA2 MUT" "BMS.754807_IC_50" 0.252356498640058 0.717470497840808 1.08081640630473 0.446354809771403 0.923628612223898 0.603946055251382 0.31745303817293 0.900918773778407 0.935005285593916 "NF1 MUT" "CGP.60474_IC_50" 0.58667945239153 0.876506729771444 0.29794109859155 0.44655148027682 0.923628612223898 -0.313047827328132 0.546158976912672 0.946853280734584 0.371826073835414 "MS-HL MUT" "AZD6244_IC_50" 0.615896680162239 0.885815598771911 0.154940300156127 0.446569045219243 0.923628612223898 0.213749842250858 0.444972556783001 0.925809648901546 0.23115936546651 "MYC MUT" "A.443654_IC_50" 0.672364689220311 0.907763880353539 0.182605161764705 0.446756558655957 0.923628612223898 0.219262580622253 0.936037852291112 0.994729228933513 0.0375599296228287 "RB1 MUT" "JNJ.26854165_IC_50" 0.556310829208277 0.867684663540343 0.11362927856226 0.446889248782083 0.923628612223898 0.139409896044958 0.386640942418098 0.915662729926209 0.171711638092786 "CTNNB1 MUT" "NU.7441_IC_50" 0.388646479094512 0.800271129338827 0.346410710607943 0.446980365332886 0.923628612223898 0.268778399270577 0.802883965368085 0.976367588173896 0.105524940323669 "MSH6 MUT" "Embelin_IC_50" 0.453301459959641 0.828509891052426 -0.382150962214413 0.447066192622544 0.923628612223898 -0.308890424766993 0.388872157556242 0.915926348152589 -0.431609631953127 "NRAS MUT" "CGP.60474_IC_50" 0.621208989260929 0.888247588669681 0.208040743203465 0.447205657201701 0.923628612223898 0.248373559255942 0.490843072301951 0.933639405738697 0.317364973834968 "CDKN2A MUT" "CGP.60474_IC_50" 0.0124905638427226 0.201322499976806 -0.559148217178463 0.44727436622967 0.923628612223898 -0.13548840683976 0.632881025760365 0.952523560833852 -0.121183411977847 "NRAS MUT" "AKT.inhibitor.VIII_IC_50" 0.0791899604864149 0.489072349846906 0.449710873809525 0.447335742602154 0.923628612223898 0.172554803261132 0.498036514828071 0.934042323734638 0.194112940291765 "MYCN MUT" "CI.1040_IC_50" 0.388340423938376 0.80015066282215 0.360329819474721 0.447381307356068 0.923628612223898 0.292805093235761 0.100443548402756 0.774133667469059 -0.709388963851947 "EZH2 MUT" "AICAR_IC_50" 0.333694997972081 0.773264085106582 -0.744700389105064 0.447410234183899 0.923628612223898 -0.521063714510999 0.330478149864371 0.902810042912437 -0.71803569912916 "NF2 MUT" "BMS.536924_IC_50" 0.18453237994124 0.660385845878234 -1.05355549825784 0.447580278572274 0.923705673457739 0.459247223703388 0.735200359627102 0.96672489654949 0.279436383534261 "NOTCH1 MUT" "Docetaxel_IC_50" 0.650546797813801 0.898942914483331 0.221814549971767 0.44779889731188 0.923705673457739 0.294641239481115 0.844402273991139 0.983349844199673 -0.100617994034639 "MYCN MUT" "FH535_IC_50" 0.0628724496331587 0.450893824743909 0.672025193895865 0.44795224929445 0.923705673457739 0.240523322881101 0.896872027069489 0.988301482344111 -0.0520903845981183 "CCND1 MUT" "BI.2536_IC_50" 0.447446638950097 0.826231147407263 -0.507509273684211 0.448019770228212 0.923705673457739 -0.307655151432208 0.637820697380845 0.953445720127982 -0.378983420432324 "IDH1 MUT" "Gefitinib_IC_50" 0.412635940307437 0.812480994891775 0.94210258254269 0.448140935954071 0.923705673457739 0.780105483201718 0.958044498634331 0.99641548698706 0.0548740441495593 "SMAD4 MUT" "Gefitinib_IC_50" 0.779475902252763 0.942683810925913 0.0898141018887418 0.448167690994888 0.923705673457739 -0.22377827121245 0.688102879165236 0.961100601384891 0.123217031874148 "EP300 MUT" "Bicalutamide_IC_50" 0.273394622687391 0.734000646544246 -0.3930944018583 0.448423833523057 0.923705673457739 -0.260128499657392 0.428954078634684 0.922428741067589 -0.264642285962128 "CDKN2A MUT" "Sorafenib_IC_50" 0.259552943490247 0.723189643810247 -0.252923008184523 0.448428021691127 0.923705673457739 0.172208067261277 0.899384106267818 0.988704788932507 0.0337954867469861 "CDKN2A MUT" "BAY.61.3606_IC_50" 0.331275795440906 0.772603259108552 -0.156196324524597 0.448434101108124 0.923705673457739 0.0879089351499023 0.585917899707049 0.949294892873838 -0.0941552391023034 "IDH1 MUT" "MK.2206_IC_50" 0.782927167300473 0.944853400298342 0.348529241237108 0.448572234207491 0.923705673457739 0.760769295966775 0.896493443633627 0.988301482344111 0.161631910251094 "CDKN2C MUT" "Sorafenib_IC_50" 0.417952215732696 0.814099702076568 0.617753611683852 0.448659946675085 0.923705673457739 0.551313560122829 0.454314861001627 0.925809648901546 0.714287111659243 "SMARCB1 MUT" "Bexarotene_IC_50" 0.849640805746248 0.963526482778845 0.215685772173916 0.448792769983392 0.923705673457739 0.765456566216158 0.60703472711777 0.949657634568742 0.565890236924952 "NOTCH1 MUT" "Doxorubicin_IC_50" 0.0554254902876199 0.421794155307929 -0.94554942713904 0.448964275324844 0.923705673457739 0.242868772176182 0.345015983327202 0.908328790918938 -0.489778136327891 "FLCN MUT" "Methotrexate_IC_50" 0.46095156309477 0.828966839128293 0.945648905622488 0.449006743277947 0.923705673457739 0.738258910522298 0.358204812319025 0.91161229252998 -1.60738462189508 "MAP2K4 MUT" "PLX4720_IC_50" 0.628085250790482 0.891895646036614 -0.267391056530216 0.449102376012449 0.923705673457739 -0.370607422481802 0.902178366821678 0.988746233284632 0.0680915971332287 "MSH2 MUT" "JNK.9L_IC_50" 0.140896999259603 0.612484704074661 -0.719332413763065 0.449111710166706 0.923705673457739 -0.290945407488436 0.168074860520644 0.84067330207935 -0.673456387781016 "CDKN2A MUT" "Docetaxel_IC_50" 0.00166795436896819 0.0594903724931988 -0.497467792857145 0.449671520138327 0.924557456957878 -0.0937723173966761 0.0820324356180895 0.744918262499236 -0.302105208877952 "HRAS MUT" "Camptothecin_IC_50" 0.877697542363021 0.971802715567801 -0.141980249203314 0.449752275050857 0.924557456957878 0.442361379303632 0.759051115822528 0.969901216545994 -0.249678557401463 "FLCN MUT" "Elesclomol_IC_50" 0.48444780113582 0.83972091053812 -0.764186601904765 0.449871190622632 0.924557456957878 -0.685233586889792 0.725262117074939 0.965402608571648 0.511653433734564 "PIK3CA MUT" "Camptothecin_IC_50" 0.224283371802034 0.696139064632428 0.398511780680539 0.449942273276878 0.924557456957878 0.158016257278477 0.467305745248475 0.929276781658587 -0.231513101918686 "CDKN2C MUT" "JNK.9L_IC_50" 0.294400582565659 0.747036827777118 0.459160930069932 0.450285941633116 0.925049606209507 0.25992509408752 0.450272271884171 0.925809648901546 0.391366422816773 "FGFR2 MUT" "Embelin_IC_50" 0.00166148367646827 0.0594903724931988 2.24935342931939 0.450514257180374 0.92516419049129 0.441109504572584 0.00618059579862324 0.368388397903175 2.23459112699028 "APC MUT" "BIBW2992_IC_50" 0.812631525367056 0.953718819162788 -0.0832154536209348 0.450550064618267 0.92516419049129 -0.265915098058186 0.142396249351693 0.831473272394224 0.583944148406169 "JAK2 MUT" "GW843682X_IC_50" 0.724039608622885 0.924072376079985 -0.49959522108844 0.450687948446704 0.925203553305262 -0.545470092228314 0.632130539062946 0.952523560833852 0.866708689732396 "MDM2 MUT" "PF.02341066_IC_50" 0.644276850492745 0.896446680008675 0.338635732203389 0.45082842482486 0.925203553305262 0.510567826935204 0.534549299768063 0.943443271455699 0.447249256018962 "MLL_AFF1 MUT" "Midostaurin_IC_50" 0.131674184987469 0.596936414943194 -1.99330003275862 0.450881767673142 0.925203553305262 -0.783581000843396 0.0601670690371174 0.70215997387469 -2.27215463966041 "GNAS MUT" "TW.37_IC_50" 0.944545477817664 0.990147156460271 0.031606120475829 0.451162949624862 0.92556667951453 -0.309834512783702 0.657277624641732 0.958313128388245 -0.19375139180662 "MAP2K4 MUT" "AZD.2281_IC_50" 0.07811458981973 0.486980385654137 0.76948655622489 0.451674075238389 0.926401261476242 0.248786192891431 0.571859762272487 0.949294892873838 0.240696362880527 "EP300 MUT" "Parthenolide_IC_50" 0.77001120147605 0.939608337497774 0.330691851851848 0.452033427000554 0.926832801452292 0.789378444271891 0.501358987742092 0.934042323734638 0.781590425105991 "PTEN MUT" "Z.LLNle.CHO_IC_50" 0.172447369535665 0.650961807890931 -0.389987534946236 0.452170318094993 0.926832801452292 -0.201223473985382 0.285698966068292 0.8879937007725 -0.321093751396221 "TP53 MUT" "Sunitinib_IC_50" 0.394495632640289 0.803226635150841 0.243209763555115 0.452197559812271 0.926832801452292 0.166818606333862 0.933915509128007 0.994729228933513 -0.022815827568531 "CDKN2A MUT" "BMS.708163_IC_50" 0.38833303758847 0.80015066282215 0.0987965838745436 0.45244658120988 0.926989190341437 0.0901456237924311 0.377738163261321 0.914419412871569 0.115748379846886 "MLLT3 MUT" "Rapamycin_IC_50" 0.641795668594679 0.896094514063559 0.451293444827587 0.452482619089081 0.926989190341437 0.620048928354472 0.703584791993349 0.962139809888331 0.394537227023358 "JAK2 MUT" "Nutlin.3a_IC_50" 0.796791753322292 0.949420392411711 0.197303108923882 0.452775733720453 0.927172939644455 -0.526492618151811 0.723100832884025 0.965402608571648 -0.289976325989869 "EWS_FLI1 MUT" "Epothilone.B_IC_50" 0.412781464420159 0.812480994891775 -0.5000102692764 0.452781110149533 0.927172939644455 0.277975158767453 0.727926529749721 0.965402608571648 0.236720377859681 "CCND3 MUT" "Bexarotene_IC_50" 0.399507761879641 0.805918367644724 -0.678767331588147 0.453071193641998 0.927553082234806 -0.539558573559102 0.60758670212043 0.949657634568742 -0.395563337962175 "KRAS MUT" "Paclitaxel_IC_50" 0.19218546521867 0.668023137615267 -0.736311832434144 0.453649258228725 0.928052390905176 -0.194829991507126 0.381220778218381 0.915134825237766 -0.541752926636185 "SMO MUT" "Cytarabine_IC_50" 0.846574360498761 0.961804643160995 0.271960941176471 0.453714575436375 0.928052390905176 -0.793508499761339 0.652968872091645 0.958313128388245 -0.582579282984829 "MYCN MUT" "BMS.708163_IC_50" 0.39940390357316 0.805918367644724 -0.252801020105963 0.453784555573377 0.928052390905176 -0.240059248159479 0.872184772697487 0.987643979884169 -0.0626638841680801 "NOTCH1 MUT" "BI.2536_IC_50" 0.0297306303677342 0.320045731267694 -1.44703316842106 0.453796497167338 0.928052390905176 -0.313837034919842 0.00245176173020482 0.262338505131915 -2.39887967478941 "CDH1 MUT" "AS601245_IC_50" 0.134581758408868 0.601893367640051 0.904655287949929 0.453924150680338 0.928052390905176 0.367668988461528 0.133576098520662 0.826682460600696 0.959967300857652 "SMO MUT" "X17.AAG_IC_50" 0.833155212376827 0.958775297273765 -0.327561152380956 0.454177757442933 0.928052390905176 -1.01915090927617 0.819854341921307 0.977383317127464 0.309576335037016 "EP300 MUT" "RDEA119_IC_50" 0.960452300713133 0.99365707033384 0.0671648968253955 0.454180638804462 0.928052390905176 0.920977593379294 0.936682024301797 0.99481859098592 0.0914851396467961 "KIT MUT" "AZD.0530_IC_50" 0.0916199825167681 0.517935750942977 -2.41420464309761 0.454324370412989 0.928052390905176 -0.9646567772844 0.43442132194499 0.922569292988365 -1.06410601516091 "STK11 MUT" "Lapatinib_IC_50" 0.132777492199552 0.59918542084564 -1.20555848780489 0.454329421394853 0.928052390905176 -0.519876222727316 0.930905207143767 0.99422596912377 0.0696955846652857 "RB1 MUT" "ABT.888_IC_50" 0.497558768355148 0.844923707565453 -0.0998012496139996 0.45436007157479 0.928052390905176 0.0952689841228165 0.302258085431245 0.894167310052 -0.157050491224783 "MAP2K4 MUT" "ABT.888_IC_50" 0.96627890208053 0.994434372972651 0.0130521864077674 0.454653111339368 0.928075620188881 -0.194761165668533 0.653088801219927 0.958313128388245 -0.143698100974762 "FGFR3 MUT" "CEP.701_IC_50" 0.514092574745204 0.85130999259055 0.853392586337758 0.45466685396379 0.928075620188881 0.716297516122883 0.733949981178808 0.96672489654949 0.402030174285945 "BRCA2 MUT" "Vinblastine_IC_50" 0.271177092536257 0.733797610851461 0.882810015267186 0.454918858768754 0.928075620188881 -0.434796412179503 0.905091228017087 0.988892684972226 0.090693158967848 "SMAD4 MUT" "NVP.TAE684_IC_50" 0.171657064931545 0.649721929411943 -1.20072418150685 0.454955486081725 0.928075620188881 -0.554436945457581 0.276334594648359 0.884207634152307 -1.01835095233454 "SMARCB1 MUT" "PAC.1_IC_50" 0.388004163214063 0.800061521593707 -1.05512072086957 0.455165871258016 0.928075620188881 -0.761883751528283 0.428707698926322 0.922428741067589 -0.944418518312627 "BRAF MUT" "AUY922_IC_50" 0.0186685287874406 0.249671250091952 -0.629883450888189 0.455170960261444 0.928075620188881 -0.147968732705672 0.0976577028161551 0.772625185318248 -0.507642809334652 "RUNX1 MUT" "AP.24534_IC_50" 0.353415109605136 0.785062892590933 1.15324711265164 0.455192514471122 0.928075620188881 0.833702905167429 0.801516511177782 0.976365695720597 0.326508279234469 "MYC MUT" "Rapamycin_IC_50" 0.261954245271373 0.724288808298587 0.719443836956525 0.455274913297723 0.928075620188881 0.424720703511014 0.43796330810032 0.922569292988365 0.534580587685983 "MYC MUT" "PD.173074_IC_50" 0.943701083757168 0.990147156460271 -0.0167502310126583 0.455311955541375 0.928075620188881 -0.152043974857831 0.380753167277741 0.915134825237766 0.200063091484337 "FAM123B MUT" "KU.55933_IC_50" 0.17586266290217 0.654035305374445 0.852085297029699 0.455607820972446 0.928465593863307 0.418231310277282 0.428546119321562 0.922428741067589 0.49898769541974 "MS-HL MUT" "Parthenolide_IC_50" 0.638598845167691 0.895624997957207 0.129992794918331 0.455822732579708 0.928613392092782 0.194196650776478 0.822414133068731 0.977759024870603 0.072053525242713 "TSC1 MUT" "Gemcitabine_IC_50" 0.785421006395659 0.946055035513406 -0.781569899130447 0.455936220563161 0.928613392092782 -1.43302775322126 0.93881619346399 0.994831655017307 0.205795658152958 "BCR_ABL MUT" "AS601245_IC_50" 0.795932833212725 0.949070823276344 0.233734333333338 0.456067663490042 0.928613392092782 0.647769282917446 0.735041014033759 0.96672489654949 0.308319476651223 "ERBB2 MUT" "Obatoclax.Mesylate_IC_50" 0.075302636438406 0.480779116570693 1.00713819884453 0.456098594337205 0.928613392092782 0.318694152358157 0.478828751203816 0.930304161706959 0.40841501195389 "TP53 MUT" "Z.LLNle.CHO_IC_50" 0.282545274025191 0.739072441127871 0.236291084309831 0.456254588762913 0.92871808452978 0.159006591280602 0.499692324562288 0.934042323734638 0.159225861237627 "CCND2 MUT" "AS601245_IC_50" 0.783716548597872 0.944974629816073 -0.286199045296164 0.456697363262752 0.92902228372161 -0.616804738682455 0.467875298863215 0.929276781658587 -0.913980686403835 "RUNX1 MUT" "AZD7762_IC_50" 0.396546537415552 0.804510548663926 -0.877086594783733 0.456749591486344 0.92902228372161 -0.59982005603828 0.252857184082049 0.875707386589409 -1.06776710470626 "KDM6A MUT" "ABT.888_IC_50" 0.0298216425322581 0.320249101969751 -0.581821940313107 0.457126668753251 0.92902228372161 -0.169673293092795 0.109296562465594 0.795960407011784 -0.415453294709787 "SMARCA4 MUT" "Bortezomib_IC_50" 0.602499199598492 0.880745626033854 0.680355079635947 0.457257758554285 0.92902228372161 0.790242227363595 0.892174976956816 0.988301482344111 -0.289337717453344 "CCND3 MUT" "PD.173074_IC_50" 0.274304739119414 0.73402283606276 1.11510898437498 0.457341290589399 0.92902228372161 0.647884472472582 0.281154526570855 0.887872038823822 1.00571829828992 "SETD2 MUT" "Embelin_IC_50" 0.264467652794753 0.72664811065258 1.13100528695653 0.457406593991029 0.92902228372161 0.605396370102351 0.186848095552009 0.851001889249827 1.32407223479993 "HRAS MUT" "PAC.1_IC_50" 0.18515850390414 0.660550500647272 1.02653247202796 0.457465760426913 0.92902228372161 0.484600681868512 0.353875956825619 0.911252930312559 0.693315219393567 "MLH1 MUT" "AZD8055_IC_50" 0.979430863263302 0.996276778834563 0.0116899959758553 0.457701752181813 0.92902228372161 0.266176095825707 0.395517781583284 0.916003810456352 0.377234715248719 "MS-HL MUT" "RO.3306_IC_50" 0.588900237572121 0.876506729771444 0.108321372996057 0.457838751715115 0.92902228372161 0.142177882248724 0.489323222201391 0.933639405738697 0.151407037911811 "KDM5C MUT" "Nilotinib_IC_50" 0.870542684929096 0.969692600253955 0.189165185958251 0.457838763947692 0.92902228372161 0.703276166153726 0.878714331085694 0.987955687349291 0.158058261937597 "GNAS MUT" "PD.0332991_IC_50" 0.505858103782258 0.847796212975596 0.467372398747386 0.458170256168123 0.92902228372161 -0.415392455528677 0.936971630641872 0.994831655017307 -0.0519160266565495 "RB1 MUT" "GSK269962A_IC_50" 0.888851092557052 0.975527896272722 -0.0518192178243547 0.458195263564245 0.92902228372161 -0.265043683387219 0.282327512401585 0.887872038823822 -0.467066533960233 "BRCA1 MUT" "Salubrinal_IC_50" 0.312277042254139 0.759215564942334 1.23206774744028 0.458203328539914 0.92902228372161 0.744451618817882 0.252689515102012 0.875707386589409 1.40323019461318 "FAM123B MUT" "BMS.708163_IC_50" 0.404079911237299 0.807904911469051 0.50843928923767 0.458269659141398 0.92902228372161 0.455856569342054 0.487096870326857 0.933639405738697 0.434838742124601 "EGFR MUT" "Imatinib_IC_50" 0.329120217318937 0.770229380276924 0.459046203065135 0.458522045063793 0.92902228372161 0.340882989723354 0.208955432436476 0.853446327418758 0.626094967610046 "JAK2 MUT" "Bryostatin.1_IC_50" 0.600354783077783 0.880698848449586 -0.251125538847122 0.45858327374167 0.92902228372161 -0.334825929879804 0.477881500634415 0.930304161706959 0.353461525691536 "CDKN2a(p14) MUT" "Parthenolide_IC_50" 0.32758381822527 0.769735904120651 -0.194275096004153 0.458733645034422 0.92902228372161 0.147495161382674 0.947307338619298 0.995668765770473 0.0154034427014236 "MYCL1 MUT" "ZM.447439_IC_50" 0.822837648589661 0.957085051223088 -0.13617865229642 0.45880654424166 0.92902228372161 -0.3571741607202 0.79827916028781 0.976360691959787 0.16157825739198 "MSH6 MUT" "AZ628_IC_50" 0.285675439960502 0.740532869253749 -1.44885749657536 0.459008427550478 0.92902228372161 -0.747979783599849 0.503175014229916 0.934042323734638 -0.780435495892464 "KRAS MUT" "BIRB.0796_IC_50" 0.968095503170769 0.994523558549405 0.00573311975953193 0.459016912875928 0.92902228372161 -0.105727210373366 0.426305315730175 0.922428741067589 -0.131069032017357 "SMARCA4 MUT" "JNK.Inhibitor.VIII_IC_50" 0.840590207809408 0.959424448728358 -0.0733689361702122 0.459032486880025 0.92902228372161 -0.256730169655503 0.932876060020228 0.994343769687907 -0.0352813720700811 "TSC1 MUT" "Bicalutamide_IC_50" 0.163994657034612 0.639629578008075 0.611034052173919 0.459036859409873 0.92902228372161 0.309582670315671 0.180269419874271 0.848722027112292 0.549717223666206 "EZH2 MUT" "MK.2206_IC_50" 0.655031707167048 0.901074441039429 0.400459605590056 0.459116242577283 0.92902228372161 0.525998254881928 0.979706726447058 0.997827228172038 0.0221951825752641 "CDKN2a(p14) MUT" "NVP.TAE684_IC_50" 0.0386414676844038 0.35636020197839 -0.626126907475493 0.459189406611821 0.92902228372161 0.194147903934409 0.388413612633735 0.915926348152589 -0.298502535842399 "CDK6 MUT" "CHIR.99021_IC_50" 0.632246527117569 0.893962968847498 -0.230648453752181 0.459463848756873 0.92902228372161 -0.33786951571714 0.907977396241227 0.989534075687441 0.0569028635487485 "MYCL1 MUT" "Vorinostat_IC_50" 0.877613488381972 0.971802715567801 -0.0694642938247014 0.459532217767885 0.92902228372161 -0.254079522396064 0.751759122485053 0.968780465757047 0.1425993763801 "CTNNB1 MUT" "PAC.1_IC_50" 0.826802073518645 0.957600463040636 0.0988082486358258 0.459614682204403 0.92902228372161 0.278897656834405 0.530932631482771 0.94320946427311 0.306436161816739 "CDK4 MUT" "PAC.1_IC_50" 0.582409844040243 0.876506729771444 -0.337877567662569 0.459778191583614 0.92902228372161 -0.382177929127099 0.591438372971639 0.949294892873838 -0.33752579442847 "BRCA1 MUT" "QS11_IC_50" 0.163398388162178 0.638865708109947 1.37027500523562 0.459778717551946 0.92902228372161 0.535258860431387 0.259389062217222 0.877052916121269 1.09051002495199 "BCR_ABL MUT" "PD.0332991_IC_50" 0.0454828236219524 0.380351183226516 -1.97525150828154 0.459815582677905 0.92902228372161 0.717764581282955 0.97810951675732 0.997655980053033 -0.0262315915835883 "EZH2 MUT" "Z.LLNle.CHO_IC_50" 0.994682443516164 0.998977896287767 0.00609120890410986 0.459861333583606 0.92902228372161 -0.619701259470208 0.566607346351708 0.949294892873838 0.584754754208132 "NRAS MUT" "A.443654_IC_50" 0.524288766749703 0.854725328793752 -0.29225938805195 0.459917996904606 0.92902228372161 -0.230225715555229 0.384824270140909 0.915331032347709 -0.457574448074813 "NF1 MUT" "PF.562271_IC_50" 0.077054285427481 0.486022094376036 0.588991628084408 0.459938850892821 0.92902228372161 0.202230788196497 0.229719778468838 0.868145256417768 0.42532614671001 "SMARCA4 MUT" "WH.4.023_IC_50" 0.794782466193449 0.948646027682356 0.53598304664391 0.459998715165068 0.92902228372161 1.32568946139763 0.288540754422534 0.889281028047524 3.50231007943952 "CCND3 MUT" "Camptothecin_IC_50" 0.872787255299877 0.970487466477047 -0.254900259962047 0.460065308389555 0.92902228372161 -0.743300477626355 0.685677705494085 0.961100601384891 -0.565746868248985 "CDKN2C MUT" "CGP.60474_IC_50" 0.477973624670653 0.836304203722611 -0.544124648275863 0.460282624280184 0.929058404982752 -0.4227580041184 0.746586708667992 0.968371047127272 -0.293284476749404 "PDGFRA MUT" "Cytarabine_IC_50" 0.954877191378563 0.992679871625456 -0.0504440534351147 0.460404973189606 0.929058404982752 0.498581530051984 0.834090977584935 0.981482581683432 0.175496147481082 "SMAD4 MUT" "GDC.0449_IC_50" 0.60210855719515 0.880745626033854 -0.1259043279994 0.460449337400096 0.929058404982752 -0.163304581904628 0.481721018317428 0.931047739646806 -0.178746612008233 "TP53 MUT" "Tipifarnib_IC_50" 0.587171783972386 0.876506729771444 -0.106962697221103 0.46050164381647 0.929058404982752 -0.100512986380579 0.603055829039274 0.949657634568742 -0.108832040639522 "CTNNB1 MUT" "MS.275_IC_50" 0.353680512696354 0.785062892590933 -0.838584903690895 0.46064391654665 0.929134368124187 -0.548830721847161 0.532197965928891 0.943403220641612 -0.65336728528793 "CTNNB1 MUT" "X17.AAG_IC_50" 0.169482170446389 0.648780670575163 -0.846101928314887 0.460856409628719 0.929346531595846 -0.399599726311694 0.171612682971051 0.842832361237713 -0.807004590990533 "EZH2 MUT" "Bleomycin_IC_50" 0.423038606425974 0.817629132463345 1.00458593233084 0.4609583911361 0.929346531595846 0.752702162069543 0.95351053791233 0.99568364368633 -0.0758615241980912 "BRCA1 MUT" "Metformin_IC_50" 0.949762724688938 0.991622481379556 -0.0455402671755733 0.461100610562774 0.929422270178846 -0.497887689809094 0.881125374653553 0.988301482344111 -0.105586203263635 "MYC MUT" "Paclitaxel_IC_50" 0.857627870795712 0.965651207814682 -0.0994749761904759 0.461563519168386 0.929943481563781 -0.183193321724641 0.377128241716592 0.914419412871569 -0.518817273347324 "BCR_ABL MUT" "JNK.Inhibitor.VIII_IC_50" 0.0139380057676279 0.213122813704679 -1.4059581453155 0.461598025943916 0.929943481563781 -0.489952952977393 0.0519548079951534 0.690213288728522 -1.15631053243808 "CDKN2A MUT" "AG.014699_IC_50" 0.0752871004467 0.480779116570693 -0.241502558630882 0.461801584553644 0.929943481563781 -0.0916481751631555 0.0731950016725377 0.739487156743738 -0.25461834554277 "NF2 MUT" "AS601245_IC_50" 0.113155932381433 0.563938179281427 -0.633679090613228 0.461951571677294 0.929943481563781 -0.238399792871704 0.521035552175485 0.939635632721979 -0.273845779692731 "CCND2 MUT" "EHT.1864_IC_50" 0.647067358065813 0.897186614618066 0.410350223214283 0.462289999687658 0.929943481563781 0.649310342326434 0.429804773254457 0.922428741067589 0.688204840420946 "STK11 MUT" "ATRA_IC_50" 0.563434134672575 0.871665208691448 0.217039252344879 0.462299703002509 0.929943481563781 -0.217536420183956 0.455696408555274 0.925809648901546 -0.262468973561538 "APC MUT" "NVP.TAE684_IC_50" 0.171307924020123 0.649721929411943 -1.0301187310475 0.462317321582195 0.929943481563781 -0.469586256776114 0.275951423590361 0.883780956691668 -0.963514284187141 "NF1 MUT" "IPA.3_IC_50" 0.575294823700539 0.872620551543038 0.246072898916968 0.462341059734917 0.929943481563781 -0.273187296751763 0.935780733406662 0.994729228933513 0.0355937886996764 "KRAS MUT" "AS601245_IC_50" 0.138025098714302 0.606087209949663 -0.318243983394922 0.462355142002394 0.929943481563781 -0.131379306180274 0.403437048745625 0.91712184556463 -0.202849179029874 "AKT2 MUT" "Lenalidomide_IC_50" 0.902952075359122 0.979694707150557 -0.0531443275971957 0.46240630723856 0.929943481563781 -0.281039599334152 0.805174249763492 0.976878758490379 -0.103893451363129 "ERBB2 MUT" "AZD6482_IC_50" 0.469581829703443 0.832012966658205 -0.349953790629877 0.46258565049912 0.930013507324006 -0.308289526557087 0.201024287048605 0.851001889249827 -0.640548453200826 "BRCA1 MUT" "BIRB.0796_IC_50" 0.601753862496804 0.880745626033854 -0.318467925430211 0.46265056585491 0.930013507324006 -0.430933116754677 0.611473799033291 0.949930222127033 -0.305428044675668 "EWS_FLI1 MUT" "Temsirolimus_IC_50" 0.0109549611245585 0.186024875233659 -1.56682930013873 0.463052984658111 0.930245739222997 -0.375835274948501 0.633505539584095 0.952523560833852 -0.322704935740385 "BRCA2 MUT" "GSK.650394_IC_50" 0.89931417436026 0.979015589910943 -0.108064486865149 0.463056531565307 0.930245739222997 -0.407167050942936 0.921823104564838 0.993931766508607 -0.0842632343153317 "CDKN2a(p14) MUT" "GNF.2_IC_50" 0.0137511101688767 0.212607581866345 -0.38155624 0.46308033026741 0.930245739222997 -0.11473899424669 0.385129629364427 0.915331032347709 -0.156279163486336 "CDK4 MUT" "PD.173074_IC_50" 0.920079792030104 0.986016435821543 0.0461580555555565 0.463478666460114 0.93072966223966 -0.288545830145873 0.751794827055012 0.968780465757047 -0.140259085362963 "FAM123B MUT" "FTI.277_IC_50" 0.609660432972869 0.884443710620525 -0.252660558058923 0.463530829420788 0.93072966223966 -0.330141392292163 0.445645606601253 0.925809648901546 -0.363116541208702 "NF1 MUT" "BIBW2992_IC_50" 0.419623599100981 0.814396237678281 0.333247585798816 0.463781241031238 0.930784229094898 0.290499191833368 0.503045036791149 0.934042323734638 -0.271331007677348 "MS-HL MUT" "BI.2536_IC_50" 0.963710948037828 0.994159243759316 0.0175399319066146 0.464068150610075 0.930784229094898 -0.16903529095172 0.635092441681212 0.953057950774478 -0.215262255095078 "EZH2 MUT" "Bexarotene_IC_50" 0.84350156015386 0.960498931426639 -0.120581846365917 0.464161912160831 0.930784229094898 -0.396866171681683 0.413087832605268 0.921714070263062 -0.514030007862079 "BCR_ABL MUT" "Bleomycin_IC_50" 0.908468195410535 0.981529929795606 -0.190262539267017 0.464178415096552 0.930784229094898 -1.19240893274878 0.497616460036449 0.934042323734638 1.10250347284463 "MDM2 MUT" "AZD6244_IC_50" 0.201578619127247 0.674012093366938 0.961837205020915 0.464192907830503 0.930784229094898 0.501482932860444 0.289032654533628 0.889281028047524 0.709469519887429 "KDM6A MUT" "BIRB.0796_IC_50" 0.82918465967733 0.958015830101332 0.0629177253874701 0.464494566014212 0.930784229094898 0.206403361938921 0.949495865199278 0.995668765770473 -0.0188402914184008 "MAP2K4 MUT" "WZ.1.84_IC_50" 0.609908202884212 0.884443710620525 0.495966166097839 0.465009750014412 0.930784229094898 0.591259081827086 0.279942553118662 0.88601917827756 1.21460563973734 "MSH6 MUT" "SB590885_IC_50" 0.0855350768405096 0.503679085433888 -1.28348812585036 0.465029226960791 0.930784229094898 -0.456531006383026 0.149767937600365 0.831473272394224 -0.93453353322136 "FLCN MUT" "Metformin_IC_50" 0.594146796278554 0.878468193610776 -0.444236000000002 0.4653169586781 0.930784229094898 -0.567265828607091 0.362806856362968 0.912255858255809 -1.28057263354144 "STK11 MUT" "BIBW2992_IC_50" 0.493372921226411 0.843282996121548 0.28284755424063 0.465369047571362 0.930784229094898 0.289564563811785 0.0594067495878146 0.70215997387469 0.767095188463864 "MYCN MUT" "Bicalutamide_IC_50" 0.0561171577325826 0.425599041693481 0.269243617594253 0.465404040975901 0.930784229094898 0.100236553277691 0.858742972427677 0.985224768537332 -0.0273177011136011 "EP300 MUT" "KIN001.135_IC_50" 0.730986314265847 0.928075690778411 0.189555555555554 0.465428650402483 0.930784229094898 0.39292507499424 0.255563373305479 0.875707386589409 0.587489165551131 "GNAS MUT" "AG.014699_IC_50" 0.146781668022762 0.619919550890177 0.701779665654269 0.465602028268284 0.930784229094898 0.310404481793864 0.466157287834538 0.929276781658587 0.327798329707143 "FLCN MUT" "Bosutinib_IC_50" 0.830449546626905 0.958318921984608 -0.222816798346061 0.465602428460379 0.930784229094898 -0.622174100393973 0.444159343332408 0.925809648901546 -1.26834540385147 "NOTCH1 MUT" "PF.562271_IC_50" 0.880936989671097 0.973189981880763 0.0582765463780907 0.465680888261278 0.930784229094898 0.237983662627092 0.74915551143068 0.968780465757047 -0.134632846947586 "MS-HL MUT" "Shikonin_IC_50" 0.0438090800038416 0.374825086237107 -0.524586944196431 0.465823789721878 0.930784229094898 -0.160976910355707 0.0180691087921971 0.513211661128791 -0.667047797237456 "BCR_ABL MUT" "Doxorubicin_IC_50" 0.64272675727432 0.896094514063559 0.45383460645725 0.465862928113331 0.930784229094898 -0.536687066257171 0.185220145895814 0.851001889249827 1.25714015918448 "MDM2 MUT" "Erlotinib_IC_50" 0.243865824257976 0.713407040228131 -1.00808931318681 0.465871311302129 0.930784229094898 -0.571342358027365 0.530209965840137 0.94320946427311 -0.536205504686808 "KIT MUT" "Temsirolimus_IC_50" 0.273478159006053 0.734000646544246 -1.25278130190477 0.465892249204902 0.930784229094898 -0.638299444304845 0.266773965368978 0.877052916121269 -1.21526273623378 "CDH1 MUT" "Nutlin.3a_IC_50" 0.743188503508589 0.929570057037101 0.217832007905136 0.465904514420582 0.930784229094898 -0.450834381649258 0.787127358101018 0.975098070483351 0.186814056301506 "NF1 MUT" "Sunitinib_IC_50" 0.464544854848201 0.829490249358073 0.507920224178405 0.465927367352756 0.930784229094898 -0.376146961765838 0.981291728691465 0.997957874252292 0.0164426206164604 "SMAD4 MUT" "AICAR_IC_50" 0.76257497358992 0.936064732612588 -0.102405307136404 0.465992201193404 0.930784229094898 -0.227170210803644 0.95387480228699 0.99568364368633 -0.0199894252623814 "CDKN2C MUT" "Etoposide_IC_50" 0.301320477034251 0.751119785777076 0.807148741258743 0.466058150134707 0.930784229094898 0.369423192738372 0.641143571953277 0.955103296458244 0.411542699481152 "PIK3R1 MUT" "Bryostatin.1_IC_50" 0.697854793875367 0.914917098377198 -0.174234723637962 0.466141768885108 0.930784229094898 -0.308178677569536 0.57955765479626 0.949294892873838 -0.236570772270341 "MSH2 MUT" "AS601245_IC_50" 0.717665701595287 0.92132587844031 -0.24767574035088 0.466178161357292 0.930784229094898 0.402240357120001 0.537407427794345 0.943597179771607 -0.421597673065287 "EGFR MUT" "Cisplatin_IC_50" 0.210277678244981 0.684261946425694 0.442574867588933 0.46635865811106 0.930867519875365 0.224146689056876 0.611349378138321 0.949930222127033 0.180270606348605 "EZH2 MUT" "PAC.1_IC_50" 0.8509212709591 0.963639744191413 0.123365102255641 0.466429508326244 0.930867519875365 0.398583671344323 0.537646651913361 0.943597179771607 0.419980149470009 "NF2 MUT" "JNK.9L_IC_50" 0.96144502195847 0.993899806776065 0.0147574573465751 0.466738110061311 0.931187402242763 0.17558117599072 0.676589003924325 0.960256725054738 0.136089101063608 "RUNX1 MUT" "BIRB.0796_IC_50" 0.420259411479315 0.81490164468446 -0.567271628498739 0.46687287155445 0.931187402242763 -0.488672071762511 0.396657468918981 0.916480913435499 -0.585244940085962 "SMAD4 MUT" "WH.4.023_IC_50" 0.270034469013074 0.732714976872933 -1.49672521898171 0.466904346603651 0.931187402242763 -0.881324858669454 0.490514299549113 0.933639405738697 -0.924513126699725 "CTNNB1 MUT" "PD.0325901_IC_50" 0.753520420873998 0.933869109446012 0.215041207478003 0.467548243594208 0.931599678837111 0.46828139429834 0.133096610724718 0.826023079873761 0.997555280817502 "KIT MUT" "QS11_IC_50" 0.976529970727221 0.996276778834563 0.0259152674825161 0.467627534294529 0.931599678837111 0.471504314597598 0.959675064594982 0.99641548698706 -0.0435589112587352 "PTEN MUT" "Roscovitine_IC_50" 0.416029923437503 0.814099702076568 -0.212902175191063 0.467990241218717 0.931599678837111 -0.170690429089498 0.749054572683457 0.968780465757047 -0.0920977882802938 "FLCN MUT" "BX.795_IC_50" 0.659308452890262 0.902400992643984 -0.353549422764229 0.468011170387739 0.931599678837111 -0.448554392498641 0.587977402911411 0.949294892873838 -0.539334692846732 "MYCN MUT" "AZD7762_IC_50" 0.188603666682636 0.663245512002727 -0.563121671469118 0.468047722971951 0.931599678837111 -0.249515373354404 0.0143485368258435 0.488235078736844 -1.11894391125744 "MYCL1 MUT" "RDEA119_IC_50" 0.252120733932355 0.717470497840808 1.0188960217143 0.46814570167271 0.931599678837111 0.582007869271674 0.968671049276829 0.997173634484198 -0.0329093345015383 "EGFR MUT" "MG.132_IC_50" 0.71688353743825 0.921306561002511 -0.275769993055554 0.46815661263805 0.931599678837111 -0.483105499835354 0.769522063235659 0.969901216545994 0.209284297145415 "FLCN MUT" "GW.441756_IC_50" 0.413209447522184 0.812782525679848 0.499395516190479 0.468181389254266 0.931599678837111 0.432347946431087 0.441240501446479 0.924472815010418 0.657074313059834 "BRCA1 MUT" "BI.2536_IC_50" 0.509665113573546 0.849059439813668 1.0606586338983 0.468340089333438 0.931599678837111 0.691615608769113 0.745581234412323 0.968371047127272 0.548449482790369 "BRAF MUT" "BMS.754807_IC_50" 0.223053469540284 0.696139064632428 -0.397404483664226 0.468506553182493 0.931599678837111 0.215962859779049 0.492685637194622 0.933639405738697 -0.26271355839681 "CTNNB1 MUT" "Metformin_IC_50" 0.712094834583643 0.919646314953749 -0.149242882748321 0.468526249248016 0.931599678837111 -0.273731119455952 0.957947138965412 0.99641548698706 -0.0228396432090074 "KRAS MUT" "DMOG_IC_50" 0.902457260117866 0.979694707150557 -0.0261361219512193 0.468580703823134 0.931599678837111 -0.147560222090386 0.00280900546440991 0.277186416993605 -0.685543384297494 "FLT3 MUT" "Gefitinib_IC_50" 0.14230320122544 0.614587916284734 -1.37798724778198 0.468718146777296 0.931599678837111 -0.618967816536964 0.359983791096528 0.91161229252998 -0.778455307619194 "HRAS MUT" "AP.24534_IC_50" 0.381174041079086 0.797756093872259 1.08835764298093 0.468763049554604 0.931599678837111 0.81503208666883 0.180511963728842 0.848722027112292 1.56546240783086 "RB1 MUT" "BIRB.0796_IC_50" 0.36442980616676 0.787388571741174 0.155827445404915 0.468838971573755 0.931599678837111 0.120482336281099 0.501479408194306 0.934042323734638 0.126757052962097 "PDGFRA MUT" "Vinorelbine_IC_50" 0.921973685705356 0.986140039233073 -0.0890790415944533 0.46888115767734 0.931599678837111 0.483572482257552 0.887036146907281 0.988301482344111 0.128940974853054 "MYCN MUT" "Dasatinib_IC_50" 0.0171727210955785 0.240174702440681 2.0992737021645 0.468894332215053 0.931599678837111 0.552382169100605 0.732194816293702 0.966676227971091 -0.317750437047921 "CDKN2C MUT" "BMS.536924_IC_50" 0.639736396571283 0.895624997957207 -0.477095542955329 0.46915432827071 0.931676531115213 -0.546518910289424 0.769698426692095 0.969901216545994 0.343826803005696 "MLL_AFF1 MUT" "AKT.inhibitor.VIII_IC_50" 0.383723880060425 0.798569876743396 -0.987709536206897 0.469207655607036 0.931676531115213 -0.715355265599438 0.179342828714573 0.848722027112292 -1.49615998731022 "ERBB2 MUT" "WZ.1.84_IC_50" 0.151290474860604 0.625830613280407 -1.39280680318544 0.469338588703608 0.931676531115213 -0.595242083222191 0.15573221750419 0.837288218996252 -1.34320120241563 "CTNNB1 MUT" "SB590885_IC_50" 0.543692109810521 0.862633715268747 -0.336931296157451 0.469411598389172 0.931676531115213 -0.336153133011211 0.198434338269993 0.851001889249827 -0.692309719611574 "BRCA1 MUT" "Obatoclax.Mesylate_IC_50" 0.759973190607847 0.935327315103698 0.35304646509599 0.469499095400162 0.931676531115213 -0.614193160381887 0.935646743610313 0.994729228933513 0.0901747984579685 "MSH2 MUT" "Pyrimethamine_IC_50" 0.42840929988277 0.820918238409269 -0.758964810996567 0.469656248951438 0.931676531115213 -0.587856552369032 0.997150627060548 0.999545005862799 -0.00350564559010839 "FLCN MUT" "Doxorubicin_IC_50" 0.0375307751146632 0.352079059947973 1.81836903671329 0.469716855717402 0.931676531115213 0.394003835127077 0.53363911133994 0.943443271455699 0.66695473441361 "GNAS MUT" "Midostaurin_IC_50" 0.271095041137373 0.733797610851461 0.655606512237763 0.46977226734984 0.931676531115213 0.331920664074431 0.611965600097573 0.949930222127033 0.276964067419758 "SMARCA4 MUT" "CGP.60474_IC_50" 0.835853641693062 0.959122768755193 -0.223638366325369 0.469952802756687 0.931826488341626 -0.580862703033081 0.521819946017881 0.939635632721979 -1.15556835198232 "PTEN MUT" "ABT.888_IC_50" 0.536273717845868 0.859994020980345 -0.0815112964601761 0.470077709756751 0.931866102756631 -0.0823183713855313 0.180155283780193 0.848722027112292 -0.179413976670344 "EGFR MUT" "PHA.665752_IC_50" 0.330939325788498 0.772603259108552 0.428180448275863 0.470237177113033 0.931880196412059 0.313224598389572 0.149412130732599 0.831473272394224 0.656947637478261 "PDGFRA MUT" "X17.AAG_IC_50" 0.627903640975739 0.891797894691435 -0.477976921455936 0.470360794523335 0.931880196412059 -0.626237464409769 0.582469638040538 0.949294892873838 0.483112773136972 "JAK2 MUT" "Salubrinal_IC_50" 0.616639463762721 0.885815598771911 -0.499582420091319 0.470639680390329 0.931880196412059 -0.58741332140648 0.739851403090578 0.96672489654949 0.406553190267756 "EP300 MUT" "GW843682X_IC_50" 0.17513840175113 0.653333117096956 -2.34239584745761 0.470706867264726 0.931880196412059 -0.642135110403416 0.173486917194474 0.844239622796781 -2.43731095522507 "KDM6A MUT" "Bortezomib_IC_50" 0.945034192882516 0.990147156460271 -0.0440332794237557 0.470903952393394 0.931880196412059 0.374936526123522 0.656110677600047 0.958313128388245 0.297044865562147 "MAP2K4 MUT" "Erlotinib_IC_50" 0.568657739402585 0.872389778906173 0.493557619047619 0.471112399353151 0.931880196412059 0.566714343022304 0.903117896095394 0.988746233284632 0.12004503804765 "KDR MUT" "TW.37_IC_50" 0.242423061438219 0.711722052440603 -0.913065322846453 0.471116123910615 0.931880196412059 -0.512722923841853 0.323574292455187 0.900918773778407 -0.746820199019351 "NRAS MUT" "Axitinib_IC_50" 0.746742070850979 0.931110103613801 0.0966983672419339 0.471154318611261 0.931880196412059 0.189921873777048 0.395815716973209 0.916003810456352 0.253863774662059 "KDR MUT" "WO2009093972_IC_50" 0.940923704817015 0.989446598697723 0.0661863187066987 0.4715719876112 0.931880196412059 0.578385549433826 0.511785591864071 0.939086342216131 0.584894156706935 "MLH1 MUT" "AZD.0530_IC_50" 0.04269631836228 0.372070775939072 1.46353963402062 0.471607475673846 0.931880196412059 0.45555524590315 0.094305840256463 0.76978875672578 1.15397968510215 "SMAD4 MUT" "NVP.BEZ235_IC_50" 0.0864406402780129 0.506983418285915 0.541958356249999 0.471783841796361 0.931880196412059 0.168766117712274 0.234222378251866 0.869962136993019 0.379578999996706 "MYCN MUT" "Thapsigargin_IC_50" 0.893002464456404 0.975972789421281 -0.0880885439856365 0.471812356176064 0.931880196412059 -0.367380954246232 0.140307621974414 0.831473272394224 -1.08763225304727 "APC MUT" "Pyrimethamine_IC_50" 0.843792474451535 0.960498931426639 -0.14075597902098 0.471974351114857 0.931880196412059 -0.449151254380166 0.441104606243868 0.924472815010418 0.669524637199543 "MDM2 MUT" "AICAR_IC_50" 0.104481207399909 0.547249836715204 0.88796310412574 0.472043653609749 0.931880196412059 0.352056823077484 0.0890007873960326 0.758159640835928 0.888174515662165 "MSH6 MUT" "Lenalidomide_IC_50" 0.0854908881837801 0.503679085433888 -0.693615065681443 0.472045818189213 0.931880196412059 -0.254648004798697 0.147504759491878 0.831473272394224 -0.557262027441011 "CDH1 MUT" "S.Trityl.L.cysteine_IC_50" 0.325153931645466 0.766576072987359 -0.925330621993132 0.472088168590313 0.931880196412059 -0.378509027571397 0.782856746852964 0.973856308110695 -0.27070414007214 "KIT MUT" "SB.216763_IC_50" 0.509905506350639 0.849206188535564 -0.48127801369863 0.472632799105775 0.931880196412059 -0.508120266773485 0.328445443286821 0.902810042912437 -0.694006364780213 "RB1 MUT" "Lapatinib_IC_50" 0.399293175359586 0.805918367644724 0.241039634146342 0.472671971263012 0.931880196412059 0.18164145214637 0.998564286615637 0.999689936809094 0.000533867873687814 "MSH6 MUT" "ATRA_IC_50" 0.06995002084295 0.46849633115101 -1.18767128406275 0.472744600929516 0.931880196412059 -0.370826508274689 0.147162921500224 0.831473272394224 -0.828969540646143 "MSH6 MUT" "Elesclomol_IC_50" 0.341368880220619 0.778707276763076 0.78822552353585 0.472898603573155 0.931880196412059 0.493697436512897 0.389296936126412 0.915926348152589 0.670193914977799 "FBXW7 MUT" "BI.D1870_IC_50" 0.464574315989985 0.829490249358073 -0.250885523033128 0.472919269475157 0.931880196412059 -0.213213312892518 0.353326685775674 0.911252930312559 -0.320693567305425 "STK11 MUT" "BMS.708163_IC_50" 0.470390395855292 0.832012966658205 -0.180262769411766 0.473036330151958 0.931880196412059 -0.180088045501198 0.319948428596598 0.900918773778407 -0.266812303276046 "ERBB2 MUT" "CGP.60474_IC_50" 0.976986289904952 0.996276778834563 0.0311371513083051 0.473138859226844 0.931880196412059 0.589304842924361 0.95776341977299 0.99641548698706 0.0571307184647261 "FLT3 MUT" "GW843682X_IC_50" 0.169951297230905 0.649721929411943 -1.93902491496601 0.47320928722738 0.931880196412059 0.529929955482954 0.216767173386772 0.860576337437605 -1.82019839995337 "NOTCH1 MUT" "Sunitinib_IC_50" 0.0314970523083645 0.328181974777787 -1.55187551929823 0.473216674472536 0.931880196412059 0.400162285465631 0.229502235948048 0.868145256417768 -0.876554256959971 "VHL MUT" "AG.014699_IC_50" 0.70619968661052 0.916471600847684 0.206490365079368 0.47324857474144 0.931880196412059 0.346098631465555 0.454179564964885 0.925809648901546 0.384764696272541 "STK11 MUT" "GDC0941_IC_50" 0.215516745539548 0.688608753079032 0.490377782557919 0.47325905142409 0.931880196412059 0.229277730594233 0.269710842123327 0.878819138279722 0.466724979961978 "KDM5C MUT" "Dasatinib_IC_50" 0.852696385225725 0.964196154467744 0.365468458904107 0.47329483567447 0.931880196412059 1.17024949086789 0.691351937915834 0.961100601384891 0.677533880201474 "RUNX1 MUT" "BMS.708163_IC_50" 0.337260923525351 0.77528718153147 -0.674376011185676 0.473329888646521 0.931880196412059 -0.506229396434869 0.336614311037658 0.905430766021494 -0.676558977615202 "FGFR2 MUT" "AICAR_IC_50" 0.45024903340145 0.828077050034054 0.917108123791089 0.473447398488004 0.931880196412059 0.785179184654717 0.0414587609367958 0.658180729724545 3.34888083578927 "CDH1 MUT" "A.443654_IC_50" 0.346793637526105 0.782020929432191 -0.85995823367698 0.473634447974272 0.931880196412059 -0.436841901217937 0.691140566017026 0.961100601384891 -0.3805314599698 "MDM2 MUT" "OSI.906_IC_50" 0.80495290967959 0.952510646223648 -0.160564132451499 0.47366777144933 0.931880196412059 -0.439636550307254 0.525613419662238 0.940554660491705 -0.413119881349198 "TSC1 MUT" "Axitinib_IC_50" 0.183094889736409 0.660385845878234 -1.6758667039848 0.473819328878192 0.931880196412059 -0.762762017306432 0.361860020063862 0.91161229252998 -1.00714724326048 "PDGFRA MUT" "OSI.906_IC_50" 0.434565643647672 0.823150425912549 0.715208555944059 0.474023061785209 0.931880196412059 0.619814542592718 0.631057346190985 0.952523560833852 0.448844872614755 "NF2 MUT" "Mitomycin.C_IC_50" 0.418738567819999 0.814099702076568 -0.398222851147657 0.474037008933409 0.931880196412059 -0.27704786459679 0.621908546442706 0.950496524771391 -0.254609394495225 "CDK4 MUT" "Tipifarnib_IC_50" 0.902615067500067 0.979694707150557 0.0975250852372597 0.474118207984774 0.931880196412059 0.381228628979003 0.592614006540341 0.949294892873838 0.445368129120936 "MLH1 MUT" "Roscovitine_IC_50" 0.200199626153618 0.674012093366938 0.7669860915493 0.474205703035753 0.931880196412059 0.382883432005786 0.144299125039209 0.831473272394224 0.886463316026504 "CDK4 MUT" "GW843682X_IC_50" 0.874035519288138 0.971016943557412 -0.274304305084745 0.474346921678689 0.931880196412059 0.643582204092005 0.99361706687304 0.999469155159075 -0.0144266826008402 "TP53 MUT" "Vorinostat_IC_50" 0.792015394498444 0.94821902379896 0.0314466670843772 0.474368761081584 0.931880196412059 -0.0680613180855246 0.56348788431167 0.949294892873838 -0.0673702332663157 "MDM2 MUT" "Etoposide_IC_50" 0.0745322941006496 0.480000945545953 1.3913465034965 0.474739048818048 0.931880196412059 0.362602377609794 0.0788248838517169 0.741811190933953 1.29444466776019 "VHL MUT" "GSK269962A_IC_50" 0.828850055817838 0.958015830101332 0.251573259385666 0.474843179700605 0.931880196412059 0.785382660569204 0.255285662361986 0.875707386589409 1.37954024969615 "STK11 MUT" "JNJ.26854165_IC_50" 0.359332198230283 0.786601117838604 0.214827763593382 0.47495570839969 0.931880196412059 0.155855025499892 0.537213447106347 0.943443271455699 0.145390581556571 "APC MUT" "Bleomycin_IC_50" 0.916532891176039 0.984975746996111 -0.0638213068651764 0.474967516222802 0.931880196412059 -0.371369470818734 0.680847600979616 0.961100601384891 0.293784588012648 "JAK2 MUT" "PLX4720_IC_50" 0.227711498182574 0.699759797702227 0.935630323699425 0.475090830439383 0.931880196412059 0.491220229234189 0.419427138558301 0.922428741067589 0.626651798096367 "EZH2 MUT" "Shikonin_IC_50" 0.633998439989067 0.89399270048764 0.370313505093174 0.475102360299418 0.931880196412059 0.465535335035294 0.828548534113449 0.981081757090089 -0.177011713773298 "FLCN MUT" "GSK.650394_IC_50" 0.0383936743987145 0.355181481598942 1.93198083566433 0.475180578444102 0.931880196412059 0.430937498701424 0.162715438938852 0.839927262232576 1.66825403811829 "CTNNB1 MUT" "PLX4720_IC_50" 0.452597832878537 0.828509891052426 0.398646866586535 0.47539373573216 0.931880196412059 0.336948544569506 0.94223202553449 0.995314665488626 -0.0380857798599074 "CDK4 MUT" "SB590885_IC_50" 0.130006314339844 0.592095424437004 0.925950573807892 0.475528921449235 0.931880196412059 0.366198294063244 0.30655154433946 0.896682870760742 0.578168145036425 "ALK MUT" "Bicalutamide_IC_50" 0.457970622522126 0.828966839128293 0.326046226086958 0.47560256909745 0.931880196412059 0.298483289084566 0.816287607071269 0.977383317127464 -0.134765356858766 "EGFR MUT" "GDC0941_IC_50" 0.997294415398161 0.998981694467749 0.00137379822954785 0.475686647483207 0.931880196412059 0.233397713193165 0.721334789258608 0.965402608571648 -0.150954280749001 "EWS_FLI1 MUT" "Roscovitine_IC_50" 0.300271675700403 0.751119785777076 0.531996700097048 0.475772778698537 0.931880196412059 0.352780674976864 0.662371243103865 0.958689538788368 0.258372785255422 "ALK MUT" "PD.173074_IC_50" 0.909112114615157 0.981529929795606 0.0952258317025447 0.475900891414103 0.931880196412059 0.51273783971746 0.637354101463486 0.953240447136615 0.445009097182911 "CDKN2a(p14) MUT" "SB.216763_IC_50" 0.382587248010156 0.798569876743396 -0.115056925246153 0.475986786838118 0.931880196412059 -0.0943905682646078 0.390630440922626 0.915926348152589 -0.121548310430588 "FLCN MUT" "KU.55933_IC_50" 0.273132954737485 0.734000646544246 0.690062029702968 0.4759868297136 0.931880196412059 0.399041222909067 0.207643447439711 0.853446327418758 1.10185567899617 "CDK6 MUT" "FTI.277_IC_50" 0.647032368398046 0.897186614618066 -0.169486865619546 0.475999493009346 0.931880196412059 -0.240055645726509 0.737544351947885 0.96672489654949 -0.124601751733937 "MAP2K4 MUT" "Metformin_IC_50" 0.979205917637718 0.996276778834563 -0.0109610465116273 0.476016093171486 0.931880196412059 -0.279397958048056 0.820944092264332 0.977383317127464 0.103304577609559 "KDM6A MUT" "PF.4708671_IC_50" 0.504976584551081 0.847679261741881 -0.220428797524316 0.476206192432231 0.931880196412059 -0.232896456686929 0.444747872926587 0.925809648901546 -0.25704668185933 "CDK6 MUT" "IPA.3_IC_50" 0.455381714861419 0.828966839128293 0.548468516695959 0.47621661127942 0.931880196412059 0.439772481976413 0.710641081373558 0.962630898212352 -0.270955718415082 "MSH6 MUT" "OSI.906_IC_50" 0.704130359203426 0.915500829364901 0.275566588752198 0.476310527604715 0.931880196412059 0.486903072045232 0.674732402778746 0.960256725054738 0.303986341989065 "FBXW7 MUT" "MK.2206_IC_50" 0.539226312446464 0.861419263046422 -0.250270124197003 0.47642987906912 0.931880196412059 -0.233053727540769 0.87382185428766 0.98777404048288 -0.0674828464361562 "CDK6 MUT" "A.770041_IC_50" 0.437220853049097 0.823808548892323 1.15227320748299 0.47658721753619 0.931880196412059 0.86472209208717 0.217677086033076 0.860928912580141 2.12293905111165 "SMAD4 MUT" "Axitinib_IC_50" 0.0304667597602137 0.323654657213466 0.758587930057547 0.47680488425887 0.931880196412059 0.216480069890486 0.683121628100058 0.961100601384891 0.133778147481078 "TP53 MUT" "Bexarotene_IC_50" 0.77423821137166 0.94153218611416 -0.04054717754061 0.47709659264115 0.931880196412059 -0.0931143432393449 0.454319686020912 0.925809648901546 -0.109041608840278 "NRAS MUT" "PHA.665752_IC_50" 0.326141722571129 0.768089270260991 0.291758058389579 0.477130915733442 0.931880196412059 0.217312414388669 0.190949018965551 0.851001889249827 0.443622325353257 "SMAD4 MUT" "BIRB.0796_IC_50" 0.959178556224962 0.993456347206305 0.0125188392445881 0.477158496387305 0.931880196412059 -0.170718133538563 0.876568646620544 0.987838063957761 -0.0400096342515324 "SMAD4 MUT" "Nutlin.3a_IC_50" 0.124115598549151 0.584448902818138 0.576841534993696 0.477304293564741 0.931880196412059 0.25068772132029 0.544443583188174 0.946853280734584 0.23466927318381 "SETD2 MUT" "LFM.A13_IC_50" 0.389561416174523 0.801307549598838 -0.673836434782616 0.477339969463291 0.931880196412059 -0.525698497736065 0.714149633051063 0.962630898212352 -0.285920018655656 "ALK MUT" "JNK.9L_IC_50" 0.378623686206139 0.795952477739693 0.85628161551724 0.477489136916817 0.931880196412059 0.539857958123193 0.808287404166269 0.977383317127464 0.329865038817541 "NRAS MUT" "AZ628_IC_50" 0.00477553785381238 0.118778793432633 -1.67585563337756 0.477583391116094 0.931880196412059 -0.327553113166309 0.254303224883113 0.875707386589409 -0.656899265053776 "AKT2 MUT" "Shikonin_IC_50" 0.161734936415892 0.637610023074489 -1.08752578732921 0.477714433229893 0.931880196412059 -0.463708522915394 0.178372891260833 0.848722027112292 -1.03281013110529 "ALK MUT" "SL.0101.1_IC_50" 0.412693339764772 0.812480994891775 -0.577050833333328 0.477714697020242 0.931880196412059 -0.437427821636426 0.893871909166406 0.988301482344111 -0.111186294844941 "MYCN MUT" "JNK.9L_IC_50" 0.375068655019822 0.794616056070335 0.284084840703003 0.477790426045874 0.931880196412059 0.181559699542697 0.438945788596066 0.923376375367667 -0.283902874635871 "FGFR3 MUT" "GW843682X_IC_50" 0.289328500100563 0.745006207420441 -1.83165652542374 0.477847553842875 0.931880196412059 0.631498120238805 0.279181395279286 0.885713545160236 -1.94206360582649 "MDM2 MUT" "Cytarabine_IC_50" 0.124655522195202 0.585263877052461 0.971538296724472 0.47790037876072 0.931880196412059 0.340122639253035 0.157225531942652 0.837524411233041 0.824115879659726 "APC MUT" "Etoposide_IC_50" 0.180341449702206 0.658614416960816 0.59622919227273 0.478170803959429 0.931880196412059 -0.215891600308587 0.615365132812713 0.950126768674963 0.258796146447245 "BRCA1 MUT" "ZM.447439_IC_50" 0.0777125642018027 0.486980385654137 1.41311146862745 0.478190022541799 0.931880196412059 0.453715782669004 0.11117184012418 0.797376436030023 1.20089573080659 "BCR_ABL MUT" "Vinblastine_IC_50" 0.602864414132247 0.880745626033854 -0.466456203809531 0.478694332644205 0.931880196412059 -0.559803919368486 0.433919166861381 0.922569292988365 0.678033035931551 "JAK2 MUT" "NVP.TAE684_IC_50" 0.546594803120714 0.863032646899058 0.858573784511775 0.478732831280809 0.931880196412059 0.824360627198048 0.281877183514056 0.887872038823822 1.89409824566285 "KDM6A MUT" "S.Trityl.L.cysteine_IC_50" 0.0418889964027157 0.368354819675836 -1.08752815535714 0.478771868181467 0.931880196412059 -0.20872526699539 0.192288795211896 0.851001889249827 -0.773763137466325 "FGFR2 MUT" "SB.216763_IC_50" 0.501358690207945 0.846334637471348 0.69307662768031 0.479023779730387 0.931880196412059 0.710160613978985 0.669559688259031 0.959230524020512 0.599023937034457 "MLL_AFF1 MUT" "LFM.A13_IC_50" 0.327629107429152 0.769735904120651 -0.766557826086964 0.479031293859378 0.931880196412059 -0.53195572727506 0.171035759622893 0.842832361237713 -1.07362937185455 "EP300 MUT" "EHT.1864_IC_50" 0.465037051216311 0.829815963803909 -0.535141163310955 0.479444854565757 0.931880196412059 -0.516664625257862 0.293880725940966 0.894167310052 -0.742160241519082 "SOCS1 MUT" "AZD7762_IC_50" 0.75751188924017 0.934762260113025 0.390943297142864 0.47946947204751 0.931880196412059 0.700792341093439 0.555242810242071 0.948071221654821 0.678911365669495 "NOTCH1 MUT" "AZD.0530_IC_50" 0.833232974672902 0.958775297273765 -0.125440519163762 0.479532008619771 0.931880196412059 -0.382730438056059 0.362093278578911 0.91161229252998 -0.588700242730136 "PIK3CA MUT" "CEP.701_IC_50" 0.277230726763079 0.735258595314258 0.292846964602487 0.479595726571243 0.931880196412059 -0.142686599019827 0.676645263528043 0.960256725054738 -0.112196108485066 "FAM123B MUT" "BMS.754807_IC_50" 0.411756086356735 0.812480994891775 0.848503127622388 0.47960591709411 0.931880196412059 0.610522738185632 0.177862978021052 0.848722027112292 1.3842042147433 "EP300 MUT" "QS11_IC_50" 0.680620935340577 0.909596174888715 0.467246724157952 0.479609582814055 0.931880196412059 0.592453259839822 0.865360179225347 0.987077901072027 0.186845186802758 "KIT MUT" "Embelin_IC_50" 0.75032210355204 0.932697982453688 -0.20461812937063 0.479679761854511 0.931880196412059 0.363388395154913 0.96177064473643 0.996625877572729 0.0305511956109684 "STK11 MUT" "PAC.1_IC_50" 0.110520664963341 0.559686423710509 0.573724987643162 0.479743100905848 0.931880196412059 0.21260709753944 0.315728680273893 0.900294798053993 0.37031031459305 "NF2 MUT" "Sorafenib_IC_50" 0.597499099714831 0.879232253518807 0.31419261672474 0.479887564898367 0.931880196412059 0.41198607520318 0.872187428436513 0.987643979884169 0.108420621020981 "PDGFRA MUT" "Shikonin_IC_50" 0.878522447189375 0.971802715567801 -0.140429303292895 0.479948555075292 0.931880196412059 0.546220143053084 0.763293278097592 0.969901216545994 0.274164231565059 "CCND3 MUT" "GDC.0449_IC_50" 0.304515625692949 0.754155959782231 0.888464999999997 0.48034459725845 0.931880196412059 0.543809984898566 0.33125262963468 0.902810042912437 0.829038329261456 "SETD2 MUT" "BMS.509744_IC_50" 0.429929188130059 0.820918238409269 0.969584813559323 0.480537872564837 0.931880196412059 0.650103924647338 0.330912680061277 0.902810042912437 1.18493156261499 "BRCA2 MUT" "CI.1040_IC_50" 0.0430532821939415 0.373759725478391 1.62253905758161 0.480563532401242 0.931880196412059 0.511139791615501 0.0540832523028726 0.697305726351784 1.37551509174921 "MS-HL MUT" "NU.7441_IC_50" 0.119998065222444 0.578243525361108 -0.303225512148714 0.480743234216914 0.931880196412059 -0.121203653251843 0.334405544261948 0.904036217258164 -0.199186467023291 "CTNNB1 MUT" "Epothilone.B_IC_50" 0.276670024164224 0.735108059249974 -0.663979569395025 0.480818870362613 0.931880196412059 0.245180002276675 0.481980275934624 0.931143535039242 -0.470457795709056 "SMAD4 MUT" "Tipifarnib_IC_50" 0.997136392164334 0.998981694467749 0.00153098565315853 0.480842676169482 0.931880196412059 0.206114243736781 0.736176500115839 0.96672489654949 0.151886708731914 "MAP2K4 MUT" "GW843682X_IC_50" 0.264330180887149 0.726560302215652 1.57796692176871 0.480916076500741 0.931880196412059 0.512749797734827 0.133985188152394 0.827361946088783 2.67144243772643 "VHL MUT" "PLX4720_IC_50" 0.541011735440197 0.861616652986104 -0.411618205029026 0.481332825443566 0.931880196412059 -0.422122458975814 0.461938697557923 0.929276781658587 -0.486856177231492 "CTNNB1 MUT" "AZD6482_IC_50" 0.335405915469873 0.773264085106582 -0.495297050793648 0.481364066680483 0.931880196412059 -0.305240597391624 0.279189502042785 0.885713545160236 -0.610234114166057 "MLH1 MUT" "AUY922_IC_50" 0.98893047878093 0.998036562927507 -0.00766401828908731 0.481426729573572 0.931880196412059 0.265155047638279 0.903678944962795 0.988746233284632 0.0642993544863867 "CTNNB1 MUT" "GNF.2_IC_50" 0.985940180200304 0.996887811168928 -0.0091127804597701 0.48143192951237 0.931880196412059 0.345442986627762 0.964044275490808 0.997051031866061 -0.0263457930345628 "MYCN MUT" "Cytarabine_IC_50" 0.964481188868413 0.994434372972651 -0.0206430138286896 0.481517512951885 0.931880196412059 0.255871944703949 0.240867600219762 0.875707386589409 -0.589923275755725 "BRCA2 MUT" "A.443654_IC_50" 0.218759373131528 0.692453909775927 1.767359707483 0.481519782357926 0.931880196412059 0.661579169362986 0.0933459134305979 0.768046723169691 2.49267729018982 "CCND3 MUT" "Lenalidomide_IC_50" 0.22091754190454 0.693711036770013 0.919919734345344 0.481623731773965 0.931880196412059 0.464055424332916 0.282964775073452 0.8879937007725 0.76980635074413 "MDM2 MUT" "BX.795_IC_50" 0.459957723831529 0.828966839128293 0.377010806584363 0.481719962344943 0.931880196412059 -0.2768372059009 0.42629519842111 0.922428741067589 0.355402634398717 "BCR_ABL MUT" "Shikonin_IC_50" 0.521026891792112 0.852790237008063 -0.658558793252589 0.481898474675522 0.931880196412059 -0.726586498070088 0.871243510075445 0.987557576640718 0.165418893259803 "CDKN2A MUT" "Cyclopamine_IC_50" 0.051092991698967 0.403339430469801 -0.349868783068783 0.481969973726422 0.931880196412059 -0.123832702870307 0.790747972261814 0.975393509832241 -0.0554370609679258 "NF1 MUT" "BMS.536924_IC_50" 0.199635190547907 0.674012093366938 0.932972527192985 0.482013175329081 0.931880196412059 0.380255739229257 0.184404118067483 0.851001889249827 1.05662337873974 "TSC1 MUT" "LFM.A13_IC_50" 0.930692607874792 0.986689293492114 0.0681353913043489 0.482141933168158 0.931880196412059 -0.519005993746542 0.904771319491008 0.988835108097421 -0.0930522291137269 "MLLT3 MUT" "AZD7762_IC_50" 0.574205273124056 0.872620551543038 -0.234629486220471 0.482274532947675 0.931880196412059 -0.228834559930193 0.74250860937434 0.966725278648091 -0.130873380649667 "MSH2 MUT" "GW.441756_IC_50" 0.340364819291349 0.778500909061878 0.441088217569786 0.482387925084853 0.931880196412059 0.317707744498885 0.302352230145749 0.894167310052 0.476416778626872 "KDM6A MUT" "PLX4720_IC_50" 0.157858814249663 0.633503899390536 -0.657625770495599 0.482692035164996 0.931880196412059 -0.292426366076207 0.260441760077613 0.877052916121269 -0.490746915138612 "EZH2 MUT" "Pyrimethamine_IC_50" 0.81549031814582 0.954576184981287 0.273097559726963 0.482798855659254 0.931880196412059 -0.691902475931779 0.279014262685429 0.885713545160236 1.45554931538446 "KDM6A MUT" "VX.680_IC_50" 0.234879280844689 0.707962074581044 -0.801828110714281 0.48283310526531 0.931880196412059 0.31057106982476 0.121670285876091 0.809590452621284 -1.17325538159777 "CDK6 MUT" "Lenalidomide_IC_50" 0.807749648531618 0.952641225877339 -0.086841228632478 0.482896710050467 0.931880196412059 -0.219474562929158 0.42961383604015 0.922428741067589 -0.269813894060191 "STK11 MUT" "KIN001.135_IC_50" 0.860346130267698 0.966384100200122 -0.0616635374149667 0.483012555832405 0.931880196412059 0.24104410066652 0.564370153670116 0.949294892873838 0.215847323712861 "NF1 MUT" "CEP.701_IC_50" 0.335460248954499 0.773264085106582 0.387158580509232 0.483044149999449 0.931880196412059 0.207390344375977 0.713300903187926 0.962630898212352 0.142328560818181 "NF2 MUT" "Embelin_IC_50" 0.168764321613584 0.647707839347554 -0.437620855601237 0.483137402185189 0.931880196412059 -0.179987976135504 0.596262972353059 0.949294892873838 -0.179792672916528 "PDGFRA MUT" "PD.0332991_IC_50" 0.568146152602368 0.872389778906173 -0.505646620331948 0.483170591274304 0.931880196412059 -0.495992669681938 0.545952479162311 0.946853280734584 -0.50902228052241 "FGFR3 MUT" "Docetaxel_IC_50" 0.56263912685206 0.871238675201477 -0.741215351351352 0.483174431101245 0.931880196412059 -0.673086846525184 0.909075251883583 0.989712770103838 -0.140485734797131 "FGFR2 MUT" "GNF.2_IC_50" 0.234841694511884 0.707962074581044 0.863288146757677 0.483272943619556 0.931880196412059 0.497056955819306 0.297188124672339 0.894167310052 0.939642491573491 "SMAD4 MUT" "Camptothecin_IC_50" 0.475104006398133 0.834671681422364 0.316980946657812 0.483344764157173 0.931880196412059 0.202445199854426 0.285009030563488 0.8879937007725 -0.444605531924931 "JAK2 MUT" "Epothilone.B_IC_50" 0.715622919720194 0.920719574063407 0.323367457142862 0.48342886831639 0.931880196412059 -0.353657452327717 0.62953208626952 0.952523560833852 0.454255683986219 "JAK2 MUT" "AZD8055_IC_50" 0.181789487190487 0.658636992153339 0.777782281437128 0.483644493343549 0.931880196412059 0.317345153306155 0.233361796200402 0.869962136993019 0.741327394012957 "PDGFRA MUT" "Temsirolimus_IC_50" 0.437317320042953 0.823808548892323 -0.795754282442751 0.483889147546488 0.931880196412059 -0.54833482835074 0.533942626401141 0.943443271455699 -0.614081980913187 "PIK3R1 MUT" "SB.216763_IC_50" 0.385394704028226 0.798746759187088 0.449949575936891 0.483944255967573 0.931880196412059 0.350532826105836 0.479513354195207 0.930304161706959 0.352658493668791 "ALK MUT" "Midostaurin_IC_50" 0.4291557245902 0.820918238409269 1.04614479482758 0.484093933800105 0.931880196412059 0.716843289692551 0.658093408465225 0.958313128388245 -0.750152331915611 "VHL MUT" "Axitinib_IC_50" 0.967080569462165 0.994434372972651 0.0261471967370433 0.484142094109458 0.931880196412059 0.376019941285489 0.490375464362083 0.933639405738697 0.41607167282732 "MLLT3 MUT" "AP.24534_IC_50" 0.548983587519699 0.864873049004332 -0.360475219642854 0.484358713831929 0.931880196412059 -0.376965679322885 0.868932739793883 0.98751437004641 -0.0972972358723088 "JAK2 MUT" "CHIR.99021_IC_50" 0.30249081985153 0.752498871456986 0.562303132919268 0.484398428792582 0.931880196412059 0.361461748567597 0.0657262014108439 0.711992560878964 1.05214338577939 "MSH6 MUT" "ZM.447439_IC_50" 0.133956213546615 0.600840976013882 -0.982539844488178 0.484611706951725 0.931880196412059 -0.364930222817394 0.245726601005734 0.875707386589409 -0.714521603751413 "ERBB2 MUT" "ABT.263_IC_50" 0.172549402088851 0.650961807890931 0.731297312463009 0.484617405167025 0.931880196412059 0.3488961297942 0.665367381472679 0.959206771190239 0.21502248015459 "TET2 MUT" "Temsirolimus_IC_50" 0.020856375251546 0.262359020692606 -3.04333328770591 0.484648557362727 0.931880196412059 -0.713608975065727 0.543878399960562 0.946853280734584 -0.935553937389129 "MLLT3 MUT" "KU.55933_IC_50" 0.533422920084394 0.858279561609675 -0.192801673840268 0.484648688533955 0.931880196412059 -0.19184368245959 0.678954837716692 0.961100601384891 -0.13335039071152 "FGFR3 MUT" "AP.24534_IC_50" 0.256140558531763 0.720311238267775 -1.81837825906732 0.484658358630183 0.931880196412059 -1.00759435323063 0.212417266835142 0.856711056658899 -1.87156485046651 "EZH2 MUT" "Roscovitine_IC_50" 0.674113660518358 0.908418658675584 0.354035069444445 0.484671143792987 0.931880196412059 -0.517817712607408 0.145210757262053 0.831473272394224 1.40303519983214 "AKT2 MUT" "Imatinib_IC_50" 0.463827488017836 0.829490249358073 0.722567542087535 0.484737076447132 0.931880196412059 0.673009440774789 0.428500503549139 0.922428741067589 0.828246818257235 "PIK3R1 MUT" "S.Trityl.L.cysteine_IC_50" 0.0604258105510173 0.443886947376523 1.76202184536083 0.484946856533356 0.931880196412059 0.357758476846575 0.0523597760507461 0.690946762417053 1.83512832628104 "TET2 MUT" "BMS.754807_IC_50" 0.387257029672344 0.799449019181797 1.15181103310103 0.485163710735054 0.931880196412059 0.786744445631732 0.692400555500597 0.961100601384891 0.633579022904745 "JAK2 MUT" "FTI.277_IC_50" 0.217260070112056 0.689960327486037 0.516662504844732 0.485312869260428 0.931880196412059 0.266241475644164 0.09507608917916 0.77097828178369 0.72106648991802 "NF1 MUT" "Temsirolimus_IC_50" 0.269027838904352 0.732006752858616 0.548653034875379 0.48542384513807 0.931880196412059 0.265712028184187 0.630453516748184 0.952523560833852 0.240859863244045 "CDKN2C MUT" "Tipifarnib_IC_50" 0.147862607999757 0.621176831431336 1.03253327513227 0.485460151956988 0.931880196412059 0.332536966446557 0.219576262600131 0.862485161824651 1.02885883999403 "MET MUT" "X17.AAG_IC_50" 0.808846429320797 0.952641225877339 0.155051720064724 0.485506628016612 0.931880196412059 -0.394091446698799 0.239405567936518 0.875707386589409 0.660752474160649 "MYCN MUT" "Gefitinib_IC_50" 0.772835344747243 0.940985837222411 0.109509791434468 0.485516809141881 0.931880196412059 0.242070744524983 0.896427909764613 0.988301482344111 -0.0521922846499958 "CDKN2C MUT" "Bortezomib_IC_50" 0.238069989596301 0.710855542080976 -1.09440768390805 0.485517892562822 0.931880196412059 -0.528122292007932 0.565929281708387 0.949294892873838 -0.616031192924986 "MSH6 MUT" "AMG.706_IC_50" 0.930425716424724 0.986689293492114 -0.0459778674540675 0.485638044880623 0.931880196412059 0.338468412275323 0.843398333484249 0.983031552042661 0.0952616107410452 "KDM5C MUT" "AMG.706_IC_50" 0.363775855896761 0.787306955898826 -0.674108982387483 0.4856595806043 0.931880196412059 -0.476760449304718 0.223491446070622 0.86643108387559 -0.826857083854611 "EP300 MUT" "CCT007093_IC_50" 0.408750593743904 0.810304102803978 -0.484032885906035 0.485969002669163 0.931880196412059 -0.410181442840133 0.468006907526074 0.929276781658587 -0.427405636374793 "PIK3CA MUT" "QS11_IC_50" 0.368833449432971 0.789246419666677 -0.251824527583034 0.486008605155551 0.931880196412059 -0.14504060832422 0.113109854451984 0.799692247086917 -0.475161911206256 "FBXW7 MUT" "Tipifarnib_IC_50" 0.187954371343033 0.663245512002727 -0.640283753808348 0.486022126741157 0.931880196412059 -0.226001891198253 0.715571844625644 0.963023723612721 -0.18153013394909 "CDKN2A MUT" "Metformin_IC_50" 0.810251950143614 0.952739326074327 0.0302002225047681 0.486034125636827 0.931880196412059 0.0851252997797732 0.87713653097375 0.987838063957761 0.0216682269962532 "RB1 MUT" "Doxorubicin_IC_50" 0.848666607054017 0.963319035946667 -0.0486704616023246 0.486560204089111 0.932476367459555 -0.113268496428816 0.134989632988465 0.828937189282754 -0.41146354866139 "RUNX1 MUT" "CCT018159_IC_50" 0.21956426189945 0.692453909775927 -1.00523424866513 0.486592796540602 0.932476367459555 -0.528521140278524 0.287115225881301 0.888563331668781 -0.871023651706997 "CDKN2A MUT" "Thapsigargin_IC_50" 0.00352995912189182 0.0963814374491735 -0.703725397067841 0.486660056657475 0.932476367459555 -0.135029279194714 0.344894860138677 0.908328790918938 -0.254235547071759 "GNAS MUT" "A.443654_IC_50" 0.216067010095402 0.688608753079032 -1.45396807508532 0.48698993971664 0.932871366485064 -0.530751292577055 0.435521676513393 0.922569292988365 -0.942164904720847 "IDH1 MUT" "BI.D1870_IC_50" 0.88502170638751 0.974449243426767 0.164868321904765 0.487126170464089 0.932871366485064 0.679759536439925 0.938531787996895 0.994831655017307 -0.0838758400345211 "KDM5C MUT" "BMS.536924_IC_50" 0.925518937325121 0.98643792569589 0.116324409556314 0.487200229903672 0.932871366485064 0.642810859559987 0.818969061694376 0.977383317127464 0.269019471183967 "APC MUT" "ABT.263_IC_50" 0.538578566429122 0.861419263046422 0.251677741873279 0.487637740000859 0.932871366485064 -0.268272416780571 0.736080694003318 0.96672489654949 0.14659330716322 "VHL MUT" "Lenalidomide_IC_50" 0.460457269917492 0.828966839128293 0.279061996161222 0.487671854172862 0.932871366485064 0.231488841324188 0.802613636712084 0.976365695720597 -0.0982682428503282 "CDH1 MUT" "WO2009093972_IC_50" 0.854939158583808 0.964766793822465 0.115853556589145 0.48769161592582 0.932871366485064 0.397099132365889 0.904389184645851 0.988782512475663 0.0826219630966658 "MSH2 MUT" "Axitinib_IC_50" 0.815694650401512 0.954589193792642 0.157715534756431 0.48778840538075 0.932871366485064 0.396074780382289 0.424545947428313 0.922428741067589 0.47776555430973 "PTEN MUT" "BMS.708163_IC_50" 0.354685878475144 0.785252181551816 0.153577827818423 0.487812209647018 0.932871366485064 0.119531767205449 0.232523756297662 0.869962136993019 0.218935919921209 "PIK3CA MUT" "RO.3306_IC_50" 0.434869820483939 0.823150425912549 0.172339096774195 0.487899769927448 0.932871366485064 0.147651587578621 0.718865317895812 0.964721180904622 0.0876273832081672 "MLLT3 MUT" "OSI.906_IC_50" 0.476047135119062 0.835198460488422 -0.322852696642689 0.487916619448612 0.932871366485064 -0.296069374806192 0.359068865887619 0.91161229252998 -0.435880121603657 "SMO MUT" "Bryostatin.1_IC_50" 0.506933089708858 0.847796212975596 -0.59248391130435 0.488421777268239 0.933344264902173 -0.580445401609254 0.552012016476659 0.947060194029534 -0.505156725807285 "SMAD4 MUT" "BMS.536924_IC_50" 0.102156595711363 0.542132629566743 -1.5418741458128 0.488499581066585 0.933344264902173 0.495030096972075 0.47652751711052 0.929855889225741 -0.674684227695398 "MDM2 MUT" "EHT.1864_IC_50" 0.385870469109399 0.798746759187088 0.350607727272729 0.48852306162523 0.933344264902173 0.277712284269061 0.394674708122816 0.915926348152589 0.333409925330013 "MLL_AFF1 MUT" "AP.24534_IC_50" 0.376248257614168 0.795051761241315 -1.73420196551724 0.488725160139333 0.933344264902173 1.24540819316176 0.93156038060056 0.994235539701634 -0.159341193790651 "FAM123B MUT" "AZD6482_IC_50" 0.313368429927826 0.759215564942334 0.890015585788553 0.48878582886004 0.933344264902173 0.515510952578715 0.544736782276476 0.946853280734584 0.529513097933966 "JAK2 MUT" "Bicalutamide_IC_50" 0.453390166705866 0.828509891052426 -0.17682915789474 0.488794524947642 0.933344264902173 -0.155360440080215 0.64542723197041 0.956971941901975 -0.110613445492642 "SMAD4 MUT" "Cisplatin_IC_50" 0.310266115495267 0.757046299071613 0.332233288401948 0.489009002124303 0.933379299002062 0.20069109024442 0.96174061898547 0.996625877572729 0.0159877065496765 "NRAS MUT" "PF.02341066_IC_50" 0.699159216671114 0.914968665673257 0.139197825703073 0.489092340219482 0.933379299002062 0.23800164074155 0.271126738994215 0.880071845397524 0.435118998574985 "EGFR MUT" "CGP.082996_IC_50" 0.978161779711363 0.996276778834563 -0.0144049300699297 0.489135682029261 0.933379299002062 -0.303486005800103 0.504567374398942 0.93503055238173 0.350806295013107 "FAM123B MUT" "CEP.701_IC_50" 0.0377648099636099 0.352922011796915 1.92137198190479 0.489324566230173 0.933379299002062 0.469605057204946 0.28339444137251 0.8879937007725 0.914997449436981 "MLH1 MUT" "Midostaurin_IC_50" 0.500667367095403 0.84613261411499 -0.366983542105264 0.489342631528649 0.933379299002062 -0.294011282492097 0.401142876995626 0.916589616820582 -0.418645307918212 "VHL MUT" "CCT007093_IC_50" 0.470303762696135 0.832012966658205 -0.260537782805431 0.489467107053651 0.933379299002062 -0.251027548013312 0.533532999678428 0.943443271455699 -0.246165946563495 "GNAS MUT" "A.770041_IC_50" 0.743755489948005 0.929570057037101 -0.485031894557826 0.489872136640748 0.933379299002062 0.832118581350323 0.930915687281321 0.99422596912377 -0.122921209505663 "FBXW7 MUT" "ABT.888_IC_50" 0.0655708306395273 0.457742485196035 -0.414420824879229 0.490009299204444 0.933379299002062 -0.131648214356845 0.725297558212313 0.965402608571648 -0.0785047021744675 "MLLT3 MUT" "ABT.263_IC_50" 0.372604630409942 0.792043637967351 0.465249047715054 0.490039686190821 0.933379299002062 0.323792942980215 0.660013216544448 0.958557216047627 0.209520499564494 "BRAF MUT" "Gemcitabine_IC_50" 0.241143571956951 0.711340033600749 -0.673046965621729 0.490157902662899 0.933379299002062 -0.292916523573031 0.112059731462324 0.797376436030023 -1.02184919653232 "BCR_ABL MUT" "GDC.0449_IC_50" 0.0352459890742018 0.347105523744792 -1.28863978682172 0.490243635128646 0.933379299002062 0.480630433026796 0.350974589671816 0.910340341961272 -0.586161201522945 "MS-HL MUT" "Tipifarnib_IC_50" 0.0338821603584132 0.340008436319851 -0.608158266347147 0.490481696269788 0.933379299002062 -0.132667610154013 0.0247002205876669 0.571841777133554 -0.705426097667029 "TET2 MUT" "Midostaurin_IC_50" 0.535127699527053 0.859397667178979 0.670685269430033 0.490484831293128 0.933379299002062 0.58121476993537 0.689264960184184 0.961100601384891 0.481825575895121 "EWS_FLI1 MUT" "A.770041_IC_50" 0.112522851214915 0.563938179281427 1.24424889160841 0.490521773679177 0.933379299002062 0.486586492484258 0.259411050041437 0.877052916121269 0.967880930203996 "HRAS MUT" "CCT018159_IC_50" 0.870988001359973 0.969815000009769 0.103327126436782 0.490526445336548 0.933379299002062 -0.411209699268254 0.858029573361206 0.984898622336936 0.114689051212892 "BRCA1 MUT" "Mitomycin.C_IC_50" 0.61150382837524 0.88496040166963 0.564680649214669 0.490637006026727 0.933379299002062 -0.600412134001529 0.447907297843173 0.925809648901546 0.826197024052636 "MET MUT" "BMS.509744_IC_50" 0.234485859671292 0.707962074581044 1.45943345762712 0.490721816577005 0.933379299002062 0.624852988630043 0.0811749732945044 0.741811190933953 2.1008602066438 "SMAD4 MUT" "FTI.277_IC_50" 0.888261987783868 0.975301439279579 -0.0294941975431817 0.490876359638469 0.933379299002062 0.135665382858182 0.741843941918498 0.96672489654949 0.0704986645292917 "AKT2 MUT" "Temsirolimus_IC_50" 0.181247228347239 0.658636992153339 1.25082103059273 0.491030908268766 0.933379299002062 0.492509466102121 0.273872933474132 0.882167181782537 0.979683981983516 "JAK2 MUT" "Camptothecin_IC_50" 0.183269112232241 0.660385845878234 1.13684678735632 0.491072910210148 0.933379299002062 0.372281050860663 0.442967268896142 0.925645250603914 0.630076643009709 "EZH2 MUT" "Vinorelbine_IC_50" 0.738299055617311 0.929570057037101 -0.257238838509322 0.491220455913984 0.933379299002062 -0.388479070013674 0.767730164215995 0.969901216545994 -0.240680580042997 "CDKN2a(p14) MUT" "BAY.61.3606_IC_50" 0.274596757027989 0.73402283606276 -0.181182215981197 0.491260704116196 0.933379299002062 0.0818273477866951 0.82877168922507 0.981081757090089 -0.037602568973511 "MS-HL MUT" "RDEA119_IC_50" 0.357343904735923 0.786601117838604 0.295898324608499 0.491382652743602 0.933379299002062 0.200028741566743 0.599150195078264 0.949657634568742 0.15814103055299 "CDKN2C MUT" "CCT007093_IC_50" 0.326661365113401 0.768905269963455 -0.407691891891889 0.491391938016477 0.933379299002062 -0.290407848131194 0.491884633917907 0.933639405738697 -0.318996819831553 "ERBB2 MUT" "GW.441756_IC_50" 0.727834478369721 0.926192578077302 -0.104353256318934 0.491447064329415 0.933379299002062 -0.208920448593202 0.976709081043191 0.99742775226181 0.00926148731703329 "KDM5C MUT" "CEP.701_IC_50" 0.932852487109569 0.98681842896288 -0.110223073055025 0.491545431982057 0.933379299002062 0.664704073837088 0.903356534184349 0.988746233284632 -0.142925810424443 "MET MUT" "Cytarabine_IC_50" 0.238870231327234 0.710855542080976 0.681912702611222 0.49187796610292 0.9337935331317 -0.302034914093581 0.559178071354554 0.949294892873838 0.312876024638805 "MYC MUT" "NVP.TAE684_IC_50" 0.495181507102799 0.843282996121548 -0.356235592391306 0.492163507672793 0.9337935331317 -0.30263721744111 0.169851103098567 0.84067330207935 -0.760858344284943 "RUNX1 MUT" "Gemcitabine_IC_50" 0.715758128514105 0.920719574063407 0.662822881118886 0.492181810376659 0.9337935331317 0.835814055084859 0.853104041675 0.984631915507353 -0.350686141834356 "FBXW7 MUT" "WH.4.023_IC_50" 0.880912879822946 0.973189981880763 0.18009326132404 0.492245482656492 0.9337935331317 0.726555345425916 0.986708455226457 0.998124818853736 -0.0192055248024337 "KDR MUT" "SB.216763_IC_50" 0.611660579676467 0.88496040166963 -0.427773483072914 0.49240334386621 0.9337935331317 -0.558531077207363 0.375511863686833 0.914419412871569 -0.727953562015756 "CCND3 MUT" "X17.AAG_IC_50" 0.502037269217835 0.846422209719112 -1.04361863809526 0.492459680308187 0.9337935331317 -0.937265242830757 0.660311728214867 0.958677204230216 -0.596856006553594 "FLT3 MUT" "Bortezomib_IC_50" 0.424615531945694 0.81889479678821 -1.04270840159271 0.492575841950669 0.9337935331317 -0.738137570759587 0.29680038850145 0.894167310052 -1.30377115268515 "RUNX1 MUT" "SB.216763_IC_50" 0.518175001978551 0.852380843541241 0.54438960286458 0.492664686350617 0.9337935331317 0.556531706897604 0.638126496605613 0.953445720127982 0.379383026834089 "TET2 MUT" "Imatinib_IC_50" 0.800895555723438 0.9507092914502 0.203526385135137 0.492709885852398 0.9337935331317 0.550952767547104 0.606604589325176 0.949657634568742 0.535209796237258 "ALK MUT" "AZD8055_IC_50" 0.99545272399635 0.998977896287767 -0.00468496428571334 0.492885398852762 0.933859387942223 0.443871952505777 0.0234673050983662 0.566340045050517 -2.21113650759868 "MYCL1 MUT" "AZD8055_IC_50" 0.927759632891491 0.986593180452362 -0.0489854754285725 0.492954938708833 0.933859387942223 -0.28716614400981 0.792214288470987 0.975393509832241 -0.151515031255832 "CCND3 MUT" "Nutlin.3a_IC_50" 0.185044710848936 0.660550500647272 1.75062841015622 0.493175821290371 0.934078581548259 0.828780394262059 0.168847140169884 0.84067330207935 1.74938360709758 "FAM123B MUT" "Bosutinib_IC_50" 0.570820340245382 0.872389778906173 0.511248720841298 0.493452911264247 0.934295333532536 -0.506850060077601 0.841258826098705 0.982150602679453 -0.169758709108896 "MLH1 MUT" "AZD.2281_IC_50" 0.560563544228748 0.870039293305752 -0.293051620093148 0.493583277966916 0.934295333532536 0.263011448272428 0.362922863795719 0.912280009424634 0.409104080293925 "ALK MUT" "Docetaxel_IC_50" 0.234161899099349 0.707628390886945 -1.52241998455598 0.493656241334502 0.934295333532536 -0.660478147293945 0.189544689019267 0.851001889249827 -1.62674511281018 "FLCN MUT" "BMS.509744_IC_50" 0.173346563757612 0.65113493295882 1.36647506802722 0.49372744924845 0.934295333532536 0.509134764611254 0.320905753877576 0.900918773778407 1.72828281800035 "MSH2 MUT" "AUY922_IC_50" 0.104518527130413 0.547249836715204 -1.16759334812031 0.493816270194992 0.934295333532536 -0.333396920620621 0.047135882671264 0.673636396626734 -1.37623738432246 "MLLT3 MUT" "ABT.888_IC_50" 0.474833382038408 0.834555294653764 0.176505397223372 0.49424538909413 0.934568673430741 0.142082487785058 0.555911568023356 0.948338577720981 0.142610789333908 "NF2 MUT" "Nutlin.3a_IC_50" 0.491648473215894 0.842990705166559 -0.28584768994494 0.494306790669234 0.934568673430741 -0.262436987155667 0.156728578964511 0.837288218996252 -0.60816115659745 "FLCN MUT" "PD.173074_IC_50" 0.967086844479946 0.994434372972651 -0.0298371568627451 0.494337291205073 0.934568673430741 -0.421555264316309 0.64436660539756 0.956479997081018 -0.432658661816637 "KIT MUT" "JW.7.52.1_IC_50" 0.513237644537456 0.85130999259055 -1.24744705084746 0.494381671858757 0.934568673430741 0.809128651204715 0.969462467884933 0.997173634484198 0.0748210171877583 "GNAS MUT" "CI.1040_IC_50" 0.252945313123533 0.717874556377469 0.838867850641026 0.494640977249102 0.934791225006831 0.446680177752668 0.46335713517189 0.929276781658587 0.473330180002991 "MAP2K4 MUT" "Mitomycin.C_IC_50" 0.967561733401065 0.994434372972651 0.025280318194217 0.494770031873568 0.934791225006831 -0.332306001731458 0.91037757553204 0.990141873133243 -0.0747955603655265 "RB1 MUT" "Paclitaxel_IC_50" 0.35365382055153 0.785062892590933 -0.398071260574986 0.494885576675724 0.934791225006831 0.131779735157647 0.0192634878165196 0.520202996939728 -1.17098428715301 "BRAF MUT" "BMS.536924_IC_50" 0.212100267535385 0.686465916902972 -0.697285400103522 0.495035134242073 0.934791225006831 0.305794593441098 0.518563095813831 0.939635632721979 -0.441560793041256 "MS-HL MUT" "CI.1040_IC_50" 0.658223055476529 0.901832606554622 0.106216619527581 0.495382074306197 0.934791225006831 0.146527595171788 0.312237162703074 0.89827607449498 0.233948260928005 "CDKN2a(p14) MUT" "Pazopanib_IC_50" 0.0205525037533311 0.259639809151257 -0.377906387322103 0.495391870403575 0.934791225006831 0.099663054374632 0.996908635231027 0.999545005862799 0.000645829632255953 "APC MUT" "Mitomycin.C_IC_50" 0.647356359246995 0.897186614618066 0.1871423995628 0.495408782380351 0.934791225006831 -0.22844117220293 0.582899239537012 0.949294892873838 0.265900383000914 "MDM2 MUT" "Salubrinal_IC_50" 0.749235337097047 0.932323030730707 0.247967586206896 0.495421042225474 0.934791225006831 0.435271932636931 0.599357561151278 0.949657634568742 0.405240326356337 "NRAS MUT" "GSK269962A_IC_50" 0.984209424125938 0.996723172778267 -0.00993307362742058 0.495446717273635 0.934791225006831 -0.332297954156749 0.887651659729722 0.988301482344111 -0.0790960320299344 "EP300 MUT" "Temsirolimus_IC_50" 0.796512981828049 0.94925279007178 0.340489969581744 0.495665504203723 0.935005382929751 0.690003879312857 0.736261593695982 0.96672489654949 0.419669521287997 "FLCN MUT" "Thapsigargin_IC_50" 0.466261461865664 0.830665605381938 0.941488262237763 0.495883670100151 0.935218278649276 -0.670569789066953 0.302457911302337 0.894167310052 1.66385567175244 "MYCL1 MUT" "Erlotinib_IC_50" 0.344507107497923 0.780249349533262 0.670401771217711 0.496026479229228 0.935223699073303 0.441801942802846 0.813284436220853 0.977383317127464 0.171431723660653 "MSH2 MUT" "Vinorelbine_IC_50" 0.113444328116803 0.564425253784497 -1.13982546167247 0.496210218084681 0.935223699073303 -0.361891597617395 0.0841137288304689 0.747749574262573 -1.23192794874919 "NF1 MUT" "KIN001.135_IC_50" 0.403716951589168 0.807888744268454 -0.177539548872181 0.496512817950276 0.935223699073303 -0.142279232168532 0.629357789435105 0.952523560833852 0.109089795480853 "KDR MUT" "CEP.701_IC_50" 0.926957959911203 0.98643792569589 -0.0980113472750322 0.496694095196169 0.935223699073303 0.531298020394035 0.981874168234463 0.997977517143419 -0.022262192100934 "PTEN MUT" "ATRA_IC_50" 0.906958327740349 0.981251818741413 -0.0251419572801184 0.496772072389419 0.935223699073303 0.117914035554765 0.669680326205966 0.959230524020512 -0.0873774750591848 "CCND1 MUT" "ZM.447439_IC_50" 0.11356751771884 0.56472179443506 0.517933826175872 0.496982629700457 0.935223699073303 0.178276434831133 0.884626957666032 0.988301482344111 0.0485566383196469 "FAM123B MUT" "GDC.0449_IC_50" 0.908566633986033 0.981529929795606 0.0704396705426347 0.497312176073159 0.935223699073303 -0.370972459821926 0.949255436685826 0.995668765770473 -0.0392788697937825 "CCND1 MUT" "Cisplatin_IC_50" 0.31830502894375 0.761267128904167 0.33890961309524 0.497352744311176 0.935223699073303 0.200992953977832 0.437428719731244 0.922569292988365 0.272519369670879 "JAK2 MUT" "CGP.60474_IC_50" 0.595554683253034 0.878883539709238 0.572798967007958 0.497378317844293 0.935223699073303 0.540793901114693 0.142479947996719 0.831473272394224 1.8993640124685 "CCND3 MUT" "ABT.888_IC_50" 0.983218568571078 0.996723172778267 -0.0157548076190479 0.497536308147397 0.935223699073303 -0.428322584999982 0.937348379075167 0.994831655017307 -0.0548029620795386 "PIK3R1 MUT" "GW843682X_IC_50" 0.0692124493624161 0.466280108629924 1.99302649657533 0.49766658980805 0.935223699073303 0.383051149327232 0.0751734723184856 0.741811190933953 2.00411574273327 "BRAF MUT" "Bryostatin.1_IC_50" 0.195958579749192 0.671674313682969 -0.230943461163356 0.49770825866484 0.935223699073303 0.125725224141636 0.991497503124894 0.999374568749539 -0.00217737287527035 "FGFR2 MUT" "KIN001.135_IC_50" 0.631220379772974 0.893419864692589 0.216425788288289 0.497727698611811 0.935223699073303 0.30651519877862 0.433007828355791 0.922569292988365 0.40433233027934 "ERBB2 MUT" "JW.7.52.1_IC_50" 0.485054416288769 0.83972091053812 -1.08948496598639 0.497730654735286 0.935223699073303 -0.651489913100875 0.699845544915949 0.961100601384891 -0.626889791857243 "NF1 MUT" "Cytarabine_IC_50" 0.653352286857209 0.900904870244158 -0.194030212300519 0.497852136637735 0.935223699073303 -0.223065280789071 0.211302454169765 0.855272470862467 -0.530634760465274 "MYC MUT" "Erlotinib_IC_50" 0.359834335129299 0.786601117838604 0.349632240641712 0.497923526297398 0.935223699073303 0.238769375996197 0.571590518739543 0.949294892873838 0.225761386276297 "PTEN MUT" "Gefitinib_IC_50" 0.880515594668516 0.973103409190031 -0.0304210444933919 0.498061575891325 0.935223699073303 0.126053216865463 0.0186273240022833 0.516564999115032 -0.464833486430386 "TET2 MUT" "NU.7441_IC_50" 0.0545893589683555 0.417578033589978 -1.58954793017129 0.498110451814216 0.935223699073303 -0.500398097305542 0.838997437677738 0.981704379975756 -0.200090364988128 "MSH2 MUT" "Mitomycin.C_IC_50" 0.159995701593344 0.636336191287136 -1.18304213609024 0.498202224407663 0.935223699073303 -0.449647580391503 0.529129685338455 0.943054040048671 -0.520472140776599 "CDH1 MUT" "Etoposide_IC_50" 0.160301135388924 0.636336191287136 1.15428869808029 0.498274165544691 0.935223699073303 0.367502283441145 0.307452412633103 0.89718581932126 0.851380892190399 "EP300 MUT" "CGP.60474_IC_50" 0.195599987191818 0.67133524752782 -1.7055188707483 0.498298828472304 0.935223699073303 -0.665588837381596 0.409630700924281 0.921036354320715 -1.05947122544701 "CDKN2A MUT" "BX.795_IC_50" 0.000715301168580707 0.0358903371647755 -0.48490736292017 0.498310602782726 0.935223699073303 -0.0783434142220489 0.0876814906471563 0.755326311453013 -0.245176912806835 "FLT3 MUT" "PF.562271_IC_50" 0.443084395462818 0.825539266593482 -0.590468133217994 0.498362219346071 0.935223699073303 -0.428536426840165 0.440161023122682 0.924472815010418 -0.58735812765418 "PDGFRA MUT" "Nutlin.3a_IC_50" 0.423707037037616 0.818030912158927 0.670640365422395 0.498509949190419 0.935223699073303 0.519608481594661 0.273262603736065 0.882167181782537 0.902436463735137 "STK11 MUT" "SB.216763_IC_50" 0.812254723048063 0.953553760130845 -0.0753187977134431 0.498598593920785 0.935223699073303 -0.207221736635885 0.360400893426073 0.91161229252998 -0.299209165727282 "CDK6 MUT" "KIN001.135_IC_50" 0.691864940006325 0.9129944327186 -0.178705405405407 0.49884278116318 0.935223699073303 -0.297439448957184 0.939531096202242 0.994831655017307 -0.0392772402882931 "MDM2 MUT" "DMOG_IC_50" 0.181305568871946 0.658636992153339 0.762624930069931 0.498971487205631 0.935223699073303 0.346687496693162 0.125179318101446 0.817150972850516 0.822288629438527 "FGFR2 MUT" "BIBW2992_IC_50" 0.524460206273456 0.854725328793752 0.855042191650853 0.499020699823694 0.935223699073303 0.874798900164357 0.367904042449111 0.913948248824328 1.57596611616679 "KRAS MUT" "GW843682X_IC_50" 0.159434003938848 0.636336191287136 -0.743638900983811 0.4990446391347 0.935223699073303 0.197559418124215 0.23025657531319 0.868326388686386 -0.720616032033405 "CTNNB1 MUT" "Gemcitabine_IC_50" 0.408081991273989 0.809871768604313 -0.876901209964422 0.499302840817485 0.935223699073303 0.479169031774828 0.982527988130129 0.998011368051263 0.024430277209782 "CTNNB1 MUT" "Parthenolide_IC_50" 0.313681698921187 0.759626633150515 -0.661919465301483 0.499672857730925 0.935223699073303 -0.40869221176635 0.144105463554034 0.831473272394224 -1.09424824558756 "NOTCH1 MUT" "Bexarotene_IC_50" 0.809462876164438 0.952641225877339 -0.0981908863636359 0.499732680814742 0.935223699073303 -0.251757618618674 0.230532074528314 0.868523106840304 -0.513870891020127 "MYCN MUT" "Imatinib_IC_50" 0.63794939701942 0.895624997957207 -0.148093060979787 0.499746546753232 0.935223699073303 -0.218613592932121 0.281150177091748 0.887872038823822 -0.431301317965565 "FLT3 MUT" "SB.216763_IC_50" 0.898729167785736 0.978795346528664 0.107243118489582 0.499798404421385 0.935223699073303 0.555455610955786 0.77894293946552 0.972337708041191 0.229627396131823 "MLLT3 MUT" "IPA.3_IC_50" 0.344571326299905 0.780249349533262 -0.433549571428576 0.499873749169026 0.935223699073303 -0.258504707741709 0.298782108559464 0.894167310052 -0.462656272738051 "CDH1 MUT" "BI.D1870_IC_50" 0.271574454289618 0.734000646544246 0.630003760115603 0.500000071039511 0.935223699073303 0.33866650263344 0.500949018283481 0.934042323734638 0.393332931806737 "SMAD4 MUT" "AMG.706_IC_50" 0.0884405698815911 0.51191930306634 0.439110392496848 0.500006219458784 0.935223699073303 0.16428998195812 0.672498946458822 0.960256725054738 0.107131055954712 "CDKN2C MUT" "BMS.708163_IC_50" 0.478489732765014 0.836304203722611 0.35346604279279 0.500029819519935 0.935223699073303 0.342851742424247 0.748975370048705 0.968780465757047 0.178063788445213 "MLH1 MUT" "AMG.706_IC_50" 0.93106502378291 0.986689293492114 0.0338109036688963 0.500040547497374 0.935223699073303 0.245772928438173 0.691769940109731 0.961100601384891 0.14423015564872 "BRAF MUT" "Salubrinal_IC_50" 0.583342794699285 0.876506729771444 0.223710030511061 0.500149863074984 0.935223699073303 0.247153377422746 0.692090234186204 0.961100601384891 0.206366950084404 "CTNNB1 MUT" "JW.7.52.1_IC_50" 0.311317959069077 0.758106606660947 -1.12236919243987 0.500218943183117 0.935223699073303 -0.451065046412294 0.679509646632612 0.961100601384891 -0.517276496131323 "RUNX1 MUT" "AZD.2281_IC_50" 0.88546502890132 0.974449243426767 0.12489902366864 0.500399157998371 0.935223699073303 0.439432766273617 0.903337751099882 0.988746233284632 -0.0918160005404991 "CDKN2a(p14) MUT" "Doxorubicin_IC_50" 0.0169343371960209 0.239099918343183 -0.403204831818773 0.500463063106341 0.935223699073303 -0.0744183279891516 0.562035244759142 0.949294892873838 -0.104232266691843 "MYCN MUT" "S.Trityl.L.cysteine_IC_50" 0.232433210464067 0.705058634100954 0.563466995151516 0.500522882801547 0.935223699073303 -0.178680909861651 0.696875252186415 0.961100601384891 -0.225740139096733 "CCND3 MUT" "Docetaxel_IC_50" 0.938004414359573 0.98883650048509 -0.0995975907335928 0.500660343765852 0.935223699073303 0.647080844281925 0.993828971331072 0.999545005862799 -0.00949366496316544 "MYCL1 MUT" "BMS.509744_IC_50" 0.483674632542822 0.839194763643102 0.500193883161515 0.500775792914572 0.935223699073303 0.361907856851627 0.60763558217098 0.949657634568742 -0.375570584063749 "MLH1 MUT" "Vinorelbine_IC_50" 0.45437138402524 0.828966839128293 -0.441783359649124 0.501132096129732 0.935223699073303 -0.294082710546153 0.821411371268007 0.97739893500462 -0.131883619654363 "BRCA2 MUT" "CGP.60474_IC_50" 0.755665925849815 0.934654823707749 0.410629428571429 0.501150016622805 0.935223699073303 -0.664747969482655 0.512689546893079 0.939635632721979 0.85259643324344 "CDH1 MUT" "A.770041_IC_50" 0.419021591974406 0.81418600684961 -0.931555332191776 0.501294788269518 0.935223699073303 -0.645233379585772 0.302109252979804 0.894167310052 -1.15804228280819 "MAP2K4 MUT" "NSC.87877_IC_50" 0.670219555937912 0.906882709825482 0.133709436257942 0.501392955585153 0.935223699073303 0.207417573428203 0.408911814689874 0.920903133902018 0.289169975084783 "EGFR MUT" "Doxorubicin_IC_50" 0.987505629858522 0.997842473406933 0.00649836422853569 0.501634884500535 0.935223699073303 -0.174544263635997 0.976076381227255 0.99742775226181 0.0124572144847701 "MYC MUT" "CCT007093_IC_50" 0.308152922806929 0.756423880316111 -0.189029336124402 0.501717170657323 0.935223699073303 -0.125626432980992 0.359264664261478 0.91161229252998 -0.18176459982405 "MLH1 MUT" "KIN001.135_IC_50" 0.135506543965091 0.602620739586366 0.414978221649486 0.501727738144201 0.935223699073303 0.184725784486267 0.426647388257199 0.922428741067589 0.210578183271339 "MLH1 MUT" "Dasatinib_IC_50" 0.049956829147644 0.398055644729792 2.73835170138887 0.501797912835609 0.935223699073303 0.784346897831927 0.0829140652186077 0.745860856369627 2.14076202885348 "SMARCA4 MUT" "IPA.3_IC_50" 0.241903325623411 0.711340033600749 0.734947967555417 0.501819503942549 0.935223699073303 0.352563847588721 0.576259795001567 0.949294892873838 0.366736593188283 "CDKN2A MUT" "TW.37_IC_50" 0.221093814867292 0.693711036770013 -0.15604413826983 0.501972046420997 0.935223699073303 0.0805376487100814 0.341512374908265 0.907180409180092 -0.131398535064482 "FGFR2 MUT" "Nilotinib_IC_50" 0.583721221326811 0.876506729771444 -0.635954358633774 0.5020841839012 0.935223699073303 -0.635638569607069 0.498556369606547 0.934042323734638 -0.996586866529169 "VHL MUT" "PD.0325901_IC_50" 0.725020120995134 0.924731250116011 0.281624742985972 0.502273045963685 0.935223699073303 0.508123468525925 0.835684772226579 0.981626636221501 0.157686423888472 "MLLT3 MUT" "PF.02341066_IC_50" 0.556892325540053 0.868264251396044 -0.307239513793103 0.502400835441442 0.935223699073303 -0.321163271267946 0.926234243454835 0.994088691803316 -0.0500948399268976 "EGFR MUT" "GNF.2_IC_50" 0.348980569387298 0.784433418559503 0.377481353146851 0.502517711559064 0.935223699073303 0.255434031140506 0.0883120892291109 0.757046008150322 0.704372933759064 "JAK2 MUT" "AS601245_IC_50" 0.831957947359068 0.958611936552287 0.145352364912283 0.502575560867557 0.935223699073303 -0.367501230723432 0.571393847751925 0.949294892873838 0.416790620658035 "HRAS MUT" "AG.014699_IC_50" 0.58958665210823 0.876506729771444 0.348805442437921 0.502942488626607 0.935223699073303 0.384086076092166 0.57962832382852 0.949294892873838 0.331435899299268 "KIT MUT" "Methotrexate_IC_50" 0.991515231702844 0.998361396647489 0.0118274346076465 0.502988587229608 0.935223699073303 -0.569679551290918 0.28087820696877 0.887872038823822 -0.957692398183228 "NRAS MUT" "Cisplatin_IC_50" 0.310232349870005 0.757046299071613 -0.28318785218137 0.503054483653345 0.935223699073303 -0.16878808128547 0.96467749100112 0.997126446878798 0.01346886688217 "SETD2 MUT" "QS11_IC_50" 0.0930070765234863 0.521674050404563 2.33057896173916 0.503274416450296 0.935223699073303 0.687720732977022 0.158233953543965 0.83854630828105 1.91288561554123 "ERBB2 MUT" "Temsirolimus_IC_50" 0.251473246451578 0.717470497840808 0.644365237591907 0.503415514603513 0.935223699073303 -0.296219007313404 0.50073098732186 0.934042323734638 -0.383221519040887 "NOTCH1 MUT" "NVP.BEZ235_IC_50" 0.342060720194287 0.778783026668672 -0.397218286005236 0.503438194939918 0.935223699073303 -0.210574644631598 0.831627593559529 0.981482581683432 -0.0920974758187825 "KDM5C MUT" "PD.173074_IC_50" 0.492459060531126 0.842990705166559 -0.572437703848668 0.503613213575007 0.935223699073303 -0.476449237706166 0.361873433499193 0.91161229252998 -0.694510668619705 "CDKN2A MUT" "XMD8.85_IC_50" 0.00660344886572363 0.140825544793469 -0.598145195767195 0.503717731861983 0.935223699073303 -0.13559632094937 0.231547860013609 0.869503824431655 -0.30151034932448 "MET MUT" "GNF.2_IC_50" 0.504782974209719 0.847679261741881 0.593096010204083 0.503843152950158 0.935223699073303 0.564202257818162 0.190378247591187 0.851001889249827 1.18307871845034 "KIT MUT" "Bryostatin.1_IC_50" 0.22592470199929 0.698134056525989 -0.685244232517487 0.50414296512734 0.935223699073303 -0.357351643478513 0.505270260319685 0.93586286551405 -0.361092514629443 "NF1 MUT" "CCT007093_IC_50" 0.533620235949646 0.858279561609675 0.132115140845071 0.504271869465762 0.935223699073303 0.142675968140138 0.49490595779946 0.933639405738697 0.156366108792862 "CCND2 MUT" "BMS.754807_IC_50" 0.43407779568684 0.823150425912549 1.0421408240418 0.504388086063818 0.935223699073303 0.737617609447493 0.967411879620053 0.997173634484198 -0.0652376330967997 "BRCA2 MUT" "Tipifarnib_IC_50" 0.417677514756129 0.814099702076568 0.744386000000005 0.504510184061419 0.935223699073303 0.409968762186164 0.372701433529586 0.913948248824328 0.813552863289476 "EGFR MUT" "Cyclopamine_IC_50" 0.95377662942907 0.992679871625456 -0.0275715492957738 0.504640904714593 0.935223699073303 -0.288868067197822 0.847875990528674 0.98378870157398 0.0923600568888186 "RB1 MUT" "Roscovitine_IC_50" 0.352398366712517 0.784969887597353 -0.249661223047014 0.504864937863076 0.935223699073303 -0.162413608998762 0.226608397998591 0.866945694839636 -0.383162146556047 "MAP2K4 MUT" "Temsirolimus_IC_50" 0.550925354985176 0.865580796066258 0.397093482914253 0.504983055154348 0.935223699073303 -0.338483304017026 0.643594331101447 0.955972780483685 -0.323694950573953 "EP300 MUT" "Gemcitabine_IC_50" 0.835740134225113 0.959122768755193 -0.486423214866428 0.505140750682369 0.935223699073303 1.0509725507279 0.675649003382472 0.960256725054738 -0.914240670864784 "KIT MUT" "CI.1040_IC_50" 0.873185362990102 0.970547215299492 0.143255074712641 0.505191283813998 0.935223699073303 0.534820938257672 0.829059392223555 0.981081757090089 0.17219068953727 "BRCA2 MUT" "TW.37_IC_50" 0.195632881500056 0.67133524752782 0.784602747629782 0.505394157915373 0.935223699073303 0.370356663567328 0.601976462778983 0.949657634568742 0.306322292087111 "TET2 MUT" "NVP.BEZ235_IC_50" 0.136078501892435 0.60335156031289 -1.33049881872511 0.505825668050385 0.935223699073303 -0.435036373232405 0.270950951485046 0.879822815407201 -1.14835007404058 "MSH6 MUT" "Methotrexate_IC_50" 0.252797372506448 0.717874556377469 -1.13801240524195 0.505880409427879 0.935223699073303 0.507567281614122 0.754148262618259 0.969352817240442 -0.246704967205494 "MLLT3 MUT" "JW.7.52.1_IC_50" 0.587060738333698 0.876506729771444 0.46988118118467 0.50610382468856 0.935223699073303 0.345492732846482 0.697044260427194 0.961100601384891 0.360701403194998 "FLT3 MUT" "GSK.650394_IC_50" 0.0784772434857895 0.486980385654137 -1.83490356806287 0.506155841215765 0.935223699073303 -0.453484122151609 0.10097294328025 0.774133667469059 -1.714305554227 "PIK3R1 MUT" "KIN001.135_IC_50" 0.460154408919441 0.828966839128293 -0.258759455782315 0.506341376925254 0.935223699073303 -0.226766681962145 0.597442655618027 0.949294892873838 -0.171997669197674 "BRCA1 MUT" "AZD8055_IC_50" 0.809424423406535 0.952641225877339 0.171855284294237 0.506430306901956 0.935223699073303 -0.370282793987647 0.828091246942359 0.981081757090089 0.149128158560477 "BRCA2 MUT" "PLX4720_IC_50" 0.179710390825542 0.658614416960816 1.1386685346154 0.506648270352554 0.935223699073303 0.503430236770983 0.372119395366366 0.913948248824328 0.69368959224319 "EGFR MUT" "Gemcitabine_IC_50" 0.854014720512628 0.964541653680809 0.158684110343744 0.506917297326011 0.935223699073303 -0.384920877000241 0.788957162026637 0.975340917051672 -0.227349485766859 "BCR_ABL MUT" "Temsirolimus_IC_50" 0.0466346821270572 0.384195372885338 -2.27312909714289 0.507098445111496 0.935223699073303 0.704022370662904 0.608699281067514 0.94989603148139 -0.572789237033289 "NRAS MUT" "Erlotinib_IC_50" 0.318750834318591 0.761267128904167 0.428828423076921 0.507539460754657 0.935223699073303 0.265312110209958 0.67654069690035 0.960256725054738 0.193121529194798 "MYCN MUT" "Shikonin_IC_50" 0.91893866864914 0.9856394101779 0.0485602228662274 0.507681795247619 0.935223699073303 -0.271196669959209 0.385641921659975 0.915331032347709 -0.466142562948245 "KRAS MUT" "AKT.inhibitor.VIII_IC_50" 0.604193541505383 0.881814764520839 0.0988917604390231 0.507756959655152 0.935223699073303 -0.115125173182987 0.383118046530146 0.915134825237766 0.186131674779075 "APC MUT" "Nilotinib_IC_50" 0.0912643689690754 0.516507787943737 0.511502023772508 0.507860834786347 0.935223699073303 -0.171362955646914 0.218052618824701 0.860928912580141 0.412582986141613 "CDH1 MUT" "CI.1040_IC_50" 0.991995448583648 0.998386941916174 -0.00639152702702632 0.507883849543256 0.935223699073303 -0.382116088544553 0.875092123219513 0.98777404048288 0.0949556989666532 "KDM6A MUT" "Axitinib_IC_50" 0.202085536642847 0.674012093366938 -0.5754732161306 0.508070553329347 0.935223699073303 -0.254298602756178 0.254857379049495 0.875707386589409 -0.466823486759662 "SMARCB1 MUT" "Midostaurin_IC_50" 0.157088276322286 0.632778052170647 -1.87108003275862 0.508187203594455 0.935223699073303 -0.672994210572253 0.1878128061096 0.851001889249827 -1.60274530588936 "TSC1 MUT" "SB590885_IC_50" 0.765124443252974 0.936968974174869 0.385258066801614 0.508278403224184 0.935223699073303 0.715761445000782 0.47829784319075 0.930304161706959 0.798588335850444 "MLH1 MUT" "Vorinostat_IC_50" 0.950957716798184 0.992018445110145 -0.0261830166333995 0.508310972756091 0.935223699073303 0.217130963736416 0.198397882773415 0.851001889249827 0.506655790134727 "GNAS MUT" "AZD6244_IC_50" 0.202119799983898 0.674012093366938 1.01789682724425 0.508338161852732 0.935223699073303 0.479718416445403 0.253456252120465 0.875707386589409 0.813230730033464 "MSH6 MUT" "PLX4720_IC_50" 0.12860690428617 0.58914788070103 -1.09184384555984 0.508422773857085 0.935223699073303 -0.421549547356887 0.108192268436391 0.792785095696032 -1.04075510178079 "SMARCA4 MUT" "NSC.87877_IC_50" 0.508938792632483 0.848726038823513 0.235807552447553 0.508498378478034 0.935223699073303 0.231214480286827 0.77975119756779 0.972337708041191 0.115857825529286 "BCR_ABL MUT" "Salubrinal_IC_50" 0.0514554829707465 0.404403667489557 -1.68102886597939 0.50850804344441 0.935223699073303 -0.597211469350849 0.288726916782823 0.889281028047524 -0.927352477099302 "EGFR MUT" "FTI.277_IC_50" 0.546080894353397 0.86289571535809 0.141499898732209 0.508563584774795 0.935223699073303 0.141565200611885 0.189011843500994 0.851001889249827 0.306657578839192 "PTEN MUT" "GDC.0449_IC_50" 0.243112598072603 0.712490868125953 -0.1779184164794 0.508613755289933 0.935223699073303 -0.0919953460844765 0.209452666327536 0.853671009479047 -0.205793893973782 "EZH2 MUT" "ABT.888_IC_50" 0.778483667165274 0.94230795258209 0.133632846743294 0.508936248107114 0.935223699073303 0.263418746176159 0.928350738909794 0.994186152404781 0.0398597080631503 "KDM6A MUT" "NSC.87877_IC_50" 0.667171745855432 0.905722930184296 -0.106990807231984 0.509032049948218 0.935223699073303 -0.162339275164251 0.838664239156767 0.981704379975756 -0.0544430487707804 "MYCN MUT" "CHIR.99021_IC_50" 0.863997714374396 0.967489995749939 0.0573242282883057 0.509074068016956 0.935223699073303 -0.2133097560148 0.0889590661741273 0.758159640835928 -0.633431639277311 "NRAS MUT" "FTI.277_IC_50" 0.474064994335863 0.834460661638643 -0.126338888359789 0.509103194107743 0.935223699073303 -0.109608541502069 0.282940020084599 0.8879937007725 -0.205583119563597 "FGFR3 MUT" "Imatinib_IC_50" 0.70371731000766 0.915500829364901 0.375244309764306 0.50917524000365 0.935223699073303 0.639704882309027 0.727642828340237 0.965402608571648 0.364090490163076 "SMO MUT" "KU.55933_IC_50" 0.503278373417794 0.846758664699095 0.595102465483246 0.509208785598506 0.935223699073303 0.519576657404529 0.703634441668559 0.962139809888331 0.332057784578501 "FGFR2 MUT" "BIRB.0796_IC_50" 0.565061878506512 0.871775968539349 -0.495556380952387 0.509340394455294 0.935223699073303 -0.548780266778301 0.994910981650234 0.999545005862799 0.00766647586608693 "TSC1 MUT" "Embelin_IC_50" 0.350833136042395 0.784966682190403 0.945763200000012 0.509389109936448 0.935223699073303 0.534046270141039 0.262087034153602 0.877052916121269 1.12114066354379 "CDKN2A MUT" "NU.7441_IC_50" 0.615733694901206 0.885815598771911 -0.0639231594257065 0.509447067185756 0.935223699073303 0.076874826695694 0.818248088849046 0.977383317127464 0.0320504693957302 "EWS_FLI1 MUT" "Sunitinib_IC_50" 0.995138633605112 0.998977896287767 -0.004413673046252 0.509465026104653 0.935223699073303 0.382702107642079 0.953509259223845 0.99568364368633 0.0425333855444356 "CDKN2A MUT" "FTI.277_IC_50" 0.001753459542297 0.0615512814037141 -0.287659462643368 0.509652783273482 0.935223699073303 -0.0582255553920906 0.656708365003988 0.958313128388245 0.0446348851610201 "STK11 MUT" "A.443654_IC_50" 0.983393815926758 0.996723172778267 -0.0190395257731955 0.509669331071332 0.935223699073303 0.392316429313455 0.527588767204611 0.942617761067065 -0.672221173220185 "SMARCA4 MUT" "Roscovitine_IC_50" 0.537011393241424 0.860710735133926 -0.599010611303348 0.509714161970414 0.935223699073303 -0.564896165294924 0.714447711419245 0.962630898212352 -0.609671682285666 "NF2 MUT" "MS.275_IC_50" 0.501250399965986 0.846334637471348 -0.474467414035089 0.509730706734288 0.935223699073303 -0.397946777889147 0.264028779095192 0.877052916121269 -0.900355877036894 "PIK3CA MUT" "Paclitaxel_IC_50" 0.861599484378515 0.966384100200122 -0.128781776273022 0.509808122947615 0.935223699073303 -0.212335887077717 0.748741068531261 0.968780465757047 -0.259101888401592 "MET MUT" "BMS.536924_IC_50" 0.388139962037312 0.80015066282215 1.51254322711865 0.509844716826773 0.935223699073303 0.849606488925549 0.079296538211659 0.741811190933953 2.91150565364394 "ERBB2 MUT" "Dasatinib_IC_50" 0.941873836886674 0.989446598697723 0.165440120591579 0.510049093678433 0.935223699073303 1.25253934089731 0.861454478770636 0.985524480087535 -0.353662466422443 "STK11 MUT" "Parthenolide_IC_50" 0.568663769349733 0.872389778906173 0.40977224489796 0.510086428474393 0.935223699073303 0.440060377256329 0.973031370727763 0.99742775226181 0.0284669180942238 "MAP2K4 MUT" "Dasatinib_IC_50" 0.977827845709141 0.996276778834563 -0.0630594197952233 0.510370979467025 0.935223699073303 1.23119870720112 0.965567512015487 0.997126446878798 0.103845971110625 "KDR MUT" "QS11_IC_50" 0.996266795902905 0.998977896287767 0.0053116486643442 0.510391974255936 0.935223699073303 0.549158021883706 0.97549726617332 0.99742775226181 -0.0343861095049916 "MLL_AFF1 MUT" "KIN001.135_IC_50" 0.357750393133337 0.786601117838604 0.506727104377097 0.510398034248523 0.935223699073303 0.361571315604503 0.933505215435489 0.99465624694452 0.0433496427745232 "CDKN2C MUT" "AKT.inhibitor.VIII_IC_50" 0.823681916439471 0.957177484110155 -0.113811367132866 0.51049894225552 0.935223699073303 -0.289760472982365 0.836026943476696 0.981626636221501 0.1232422559359 "CDKN2a(p14) MUT" "Embelin_IC_50" 0.0828643173765615 0.498552626562699 -0.215227002741871 0.510518538448258 0.935223699073303 0.0684444351369007 0.33963383957574 0.907039453844874 0.130921905419457 "BRCA2 MUT" "BMS.509744_IC_50" 0.0343971489613332 0.342467578391929 2.59004701694913 0.510688884396403 0.935223699073303 0.604577121669838 0.0442498304722577 0.659657620288543 2.45237412591018 "CDK6 MUT" "Doxorubicin_IC_50" 0.597028601509273 0.879232253518807 0.367001980008788 0.510721626764398 0.935223699073303 -0.284491841816026 0.439890520392236 0.924472815010418 0.545713166222923 "CDKN2A MUT" "AUY922_IC_50" 0.0111710293317146 0.187804952756533 -0.40310652605815 0.51076051603092 0.935223699073303 0.0740083984881059 0.363394563023927 0.912304381946028 0.158292387426922 "CDKN2C MUT" "Metformin_IC_50" 0.644352466791924 0.896446680008675 0.236817884615387 0.510788538907963 0.935223699073303 0.315471269401429 0.954262763457982 0.99568364368633 0.0309014795235805 "SETD2 MUT" "RO.3306_IC_50" 0.595541862096682 0.878883539709238 0.552700468749994 0.510915563219157 0.935223699073303 0.656607973557195 0.462809985617008 0.929276781658587 0.764081441937407 "FGFR3 MUT" "AMG.706_IC_50" 0.623960753203891 0.890041029425595 0.445358417968745 0.511159192971286 0.935223699073303 0.54965267072927 0.847144833071705 0.98378870157398 0.160914106728582 "MYCL1 MUT" "BI.D1870_IC_50" 0.711042663283031 0.919312211985394 -0.226833185989008 0.511163150609471 0.935223699073303 -0.346445344205612 0.695005535735596 0.961100601384891 0.250501015286773 "VHL MUT" "GSK.650394_IC_50" 0.462827771772439 0.829373172137011 -0.543881585237256 0.511245055444284 0.935223699073303 -0.315677021313123 0.763693791807268 0.969901216545994 -0.240363106468455 "MYC MUT" "BMS.509744_IC_50" 0.861704277613418 0.966384100200122 -0.0642473305860804 0.511332844442894 0.935223699073303 -0.184591286026027 0.231659832349456 0.86955662345542 -0.459308575238942 "MSH2 MUT" "GDC0941_IC_50" 0.814761730742209 0.954309977735381 -0.191277092975204 0.511371328489161 0.935223699073303 0.432072911951392 0.608026760300947 0.949680910698683 -0.416038041930162 "SOCS1 MUT" "Vinblastine_IC_50" 0.679572603056811 0.90920221267664 -0.522730421252368 0.511552759762882 0.935223699073303 -0.601635654224979 0.948246711288275 0.995668765770473 0.0770010877275957 "MYCL1 MUT" "BIBW2992_IC_50" 0.393591215052802 0.803073858340542 0.576236367562378 0.51159968062552 0.935223699073303 0.424175120549747 0.191818664125735 0.851001889249827 0.891759154915998 "CDK4 MUT" "X17.AAG_IC_50" 0.415595284888034 0.814099702076568 0.570307742746615 0.511675774069293 0.935223699073303 0.405216527506142 0.18747043591472 0.851001889249827 0.849112743016477 "SMARCA4 MUT" "CGP.082996_IC_50" 0.879034566901857 0.971950446794745 0.144462536973833 0.511769924875326 0.935223699073303 -0.523614152124229 0.542370341875718 0.945765861891114 -0.981332708247239 "EWS_FLI1 MUT" "BMS.536924_IC_50" 0.429276273554833 0.820918238409269 0.600003748251755 0.511936658486826 0.935223699073303 -0.399521854765285 0.546763560042192 0.947060194029534 -0.499499157556984 "GNAS MUT" "FH535_IC_50" 0.723698803416565 0.923974852378165 -0.179285779541446 0.512009130829844 0.935223699073303 -0.284894316749509 0.768171223080578 0.969901216545994 -0.144219602697129 "CDK4 MUT" "RO.3306_IC_50" 0.904157582942141 0.980083424155884 0.0565194841269836 0.512583512534826 0.935223699073303 -0.293709726428777 0.812803366118729 0.977383317127464 0.116408461029436 "CDKN2C MUT" "AG.014699_IC_50" 0.384106281091242 0.798569876743396 -0.514194002262441 0.512669940185641 0.935223699073303 -0.345136353873578 0.50972414672157 0.938298970167224 -0.397893657444017 "KIT MUT" "PF.02341066_IC_50" 0.470604735837335 0.832226335916243 -0.832226372483211 0.512734209635478 0.935223699073303 -0.725615757499856 0.93665291952807 0.99481859098592 -0.0906817890693836 "MAP2K4 MUT" "AZD8055_IC_50" 0.803852784239978 0.951995809685991 0.103003203030302 0.51276171649823 0.935223699073303 -0.211051574803923 0.892462225173452 0.988301482344111 -0.0600816516614934 "TET2 MUT" "Lenalidomide_IC_50" 0.330199314693268 0.771507527963934 -0.598200665399231 0.512831372262297 0.935223699073303 0.35780321488196 0.298689406729037 0.894167310052 0.752844071225233 "CDKN2A MUT" "KIN001.135_IC_50" 0.783618286034336 0.944974629816073 -0.0258546097201767 0.512865036749696 0.935223699073303 0.0642095494767188 0.709260171401704 0.962630898212352 0.0381292323847629 "STK11 MUT" "Bexarotene_IC_50" 0.668379250310301 0.90624062931386 -0.143453717902352 0.512885475534198 0.935223699073303 -0.195590867418519 0.958407363694889 0.99641548698706 -0.0177540604560687 "KDM6A MUT" "Thapsigargin_IC_50" 0.361071428940299 0.786914198875777 -0.584042726447418 0.512956673439805 0.935223699073303 -0.320844818688267 0.334709255487167 0.904061100359347 -0.634831506277065 "KIT MUT" "GSK.650394_IC_50" 0.125001409660645 0.586133853852264 -1.43259695104896 0.513032518518213 0.935223699073303 -0.39672847369418 0.162170724818157 0.839927262232576 -1.30223034416831 "STK11 MUT" "JNK.Inhibitor.VIII_IC_50" 0.877865290340722 0.971802715567801 0.0374362336093861 0.513054368793255 0.935223699073303 -0.152295536885431 0.79197267074398 0.975393509832241 -0.069111688102253 "CDH1 MUT" "Bortezomib_IC_50" 0.757564813393943 0.934762260113025 0.313467989690722 0.513310437431583 0.935223699073303 0.553681217384541 0.753930193390084 0.969260863853118 0.310547806269958 "FLCN MUT" "BI.2536_IC_50" 0.886660407005537 0.974920276664129 0.187589326530613 0.513331473804825 0.935223699073303 -0.510367666358983 0.854968878195176 0.984631915507353 0.440000121341282 "JAK2 MUT" "Tipifarnib_IC_50" 0.586220800148126 0.876506729771444 0.463338508771936 0.513375171483839 0.935223699073303 -0.369933192844825 0.361186542400522 0.91161229252998 0.83164556129681 "MYCL1 MUT" "A.770041_IC_50" 0.927125027112216 0.98643792569589 -0.0964646975945032 0.513438668745568 0.935223699073303 -0.568698522687033 0.0661477704587632 0.712070726599122 -1.91241889193964 "EGFR MUT" "XMD8.85_IC_50" 0.85026347113204 0.963526482778845 0.110586190140845 0.513638128498374 0.935223699073303 -0.326958290048826 0.597831455799185 0.949294892873838 0.306716336355646 "MS-HL MUT" "MS.275_IC_50" 0.63909792238035 0.895624997957207 0.178766182776982 0.513704892481287 0.935223699073303 0.209587087155314 0.252890874867542 0.875707386589409 0.506084184934257 "EP300 MUT" "PHA.665752_IC_50" 0.892562776587946 0.975972789421281 0.131313187919462 0.513748783235771 0.935223699073303 0.63041157922745 0.54898257643299 0.947060194029534 0.59666864480045 "FLT3 MUT" "PD.173074_IC_50" 0.213630659148554 0.688117861819268 -1.03661356816701 0.513773753414707 0.935223699073303 -0.470772158135897 0.708596649594491 0.962630898212352 -0.287973454288068 "KDR MUT" "AUY922_IC_50" 0.280948534014305 0.737978092452245 -1.18121278222995 0.513920604984689 0.935223699073303 -0.480667418646839 0.551349874523912 0.947060194029534 -0.630289844776271 "KRAS MUT" "BI.2536_IC_50" 0.1305669788759 0.59349449267004 -0.74297238717867 0.514053663046129 0.935223699073303 -0.204339241048977 0.211569993202522 0.855272470862467 -0.697764296266651 "BRCA2 MUT" "NVP.TAE684_IC_50" 0.175040379807704 0.653333117096956 2.35857521476507 0.514234465934479 0.935223699073303 0.938833189780149 0.086974674669295 0.754318443103524 3.01811963105902 "MYCL1 MUT" "Doxorubicin_IC_50" 0.675680856145958 0.908552538148308 0.260232026455028 0.514240684660913 0.935223699073303 0.252961141272838 0.866937511610765 0.987077901072027 -0.108358770100346 "JAK2 MUT" "PF.4708671_IC_50" 0.744288724095885 0.929937110785116 0.145994897959185 0.51444516756158 0.935223699073303 0.289671177293589 0.818687093978717 0.977383317127464 -0.11335812089498 "JAK2 MUT" "Sunitinib_IC_50" 0.321053653726071 0.762015213745527 1.35637591695107 0.51464530185298 0.935223699073303 0.650692644084863 0.111783649112281 0.797376436030023 2.34217882973499 "SMO MUT" "Etoposide_IC_50" 0.345173650819538 0.780816911087192 -1.6370774896552 0.514695921734398 0.935223699073303 -0.731908182115872 0.194170064937191 0.851001889249827 -2.12301274159214 "SMAD4 MUT" "FH535_IC_50" 0.163599835076988 0.638931457923803 -0.421660563805692 0.51492375306054 0.935223699073303 -0.174006486319412 0.178241809015554 0.848722027112292 -0.418923161480146 "BRAF MUT" "Bleomycin_IC_50" 0.609755034097308 0.884443710620525 -0.238638073389062 0.514959267239851 0.935223699073303 0.274006352904557 0.291255425346788 0.891022884087089 -0.568618544639284 "RUNX1 MUT" "Vinblastine_IC_50" 0.234425840804002 0.707962074581044 -1.22909106210392 0.515024184053131 0.935223699073303 -0.486448214492363 0.223616204794285 0.86643108387559 -1.17110277339429 "IDH1 MUT" "PD.0332991_IC_50" 0.302929917984866 0.752537231223384 -1.4379454969072 0.515173738823447 0.935223699073303 -0.7211499385971 0.334538654500676 0.904036217258164 -1.26918553490311 "CDK4 MUT" "ABT.888_IC_50" 0.142048565283054 0.614482858392011 0.52136429300729 0.515235509269749 0.935223699073303 0.195245107353381 0.453271903400312 0.925809648901546 0.262668136186056 "PIK3CA MUT" "Imatinib_IC_50" 0.399612111452211 0.805918367644724 0.332036048951051 0.515238166322312 0.935223699073303 0.253842914552223 0.431103649292389 0.922569292988365 0.359560706927387 "FGFR2 MUT" "DMOG_IC_50" 0.0399727344910571 0.361141839503332 1.84127119377162 0.515244631904743 0.935223699073303 0.534356248897257 0.585824708233437 0.949294892873838 0.532189998518088 "CDKN2A MUT" "A.770041_IC_50" 0.00179051031012767 0.0626044175757632 -0.955399585978832 0.515263730822909 0.935223699073303 -0.17049334084307 0.659564212532023 0.958313128388245 -0.149409291282547 "KIT MUT" "Parthenolide_IC_50" 0.765591456509582 0.936968974174869 0.337235622895619 0.515347537985096 0.935223699073303 0.70048455591151 0.428499169688518 0.922428741067589 0.927663838381942 "EGFR MUT" "AZD6244_IC_50" 0.677196473972211 0.908720747099578 0.212948289079229 0.51539268817329 0.935223699073303 0.304257888048289 0.820991967182218 0.977383317127464 0.109032997131682 "RUNX1 MUT" "FTI.277_IC_50" 0.320510001880081 0.762015213745527 0.491456197573653 0.515587825182149 0.935223699073303 0.292040327745185 0.419012255449489 0.922428741067589 0.421681255327169 "RB1 MUT" "BMS.754807_IC_50" 0.617450660998482 0.886326305706232 0.150383286870664 0.515638417319479 0.935223699073303 -0.167221934767236 0.748841447142239 0.968780465757047 -0.10732098455411 "TET2 MUT" "Epothilone.B_IC_50" 0.83698065033021 0.959212493377535 -0.27801053077816 0.515661007259361 0.935223699073303 0.5053645667468 0.598124113796601 0.94937477774851 -0.851311032264201 "NF2 MUT" "S.Trityl.L.cysteine_IC_50" 0.571071248177986 0.872389778906173 -0.380193409090907 0.515684365472006 0.935223699073303 -0.245142814657902 0.524164556434078 0.940554660491705 -0.476705891371097 "TP53 MUT" "XMD8.85_IC_50" 0.51528909339325 0.852194122611816 0.144441239878544 0.515725029287823 0.935223699073303 0.129448467262206 0.682000367587361 0.961100601384891 0.0974739041241438 "ERBB2 MUT" "Pazopanib_IC_50" 0.73225455557036 0.928176068595523 0.158698603046218 0.515786768286187 0.935223699073303 -0.264724202646739 0.491205907065939 0.933639405738697 -0.309218314066843 "TSC1 MUT" "Doxorubicin_IC_50" 0.897435455840419 0.978169401487329 0.178048090434786 0.515810442740149 0.935223699073303 -0.559431136303149 0.673621951493793 0.960256725054738 0.552202669641627 "PIK3R1 MUT" "ABT.263_IC_50" 0.741475464788824 0.929570057037101 -0.255739518774702 0.515859448929194 0.935223699073303 -0.453554718838703 0.669765620926832 0.959230524020512 -0.285767824804047 "SMAD4 MUT" "A.443654_IC_50" 0.0382580655389412 0.354296016737578 -1.6015785081562 0.515955841640987 0.935223699073303 -0.340614233126286 0.193748172122351 0.851001889249827 -1.08709719456192 "CDK6 MUT" "Cyclopamine_IC_50" 0.949713881584775 0.991622481379556 -0.054105841924397 0.515998274652432 0.935223699073303 -0.509393961253746 0.902730649407952 0.988746233284632 -0.128634868037428 "CDH1 MUT" "Pyrimethamine_IC_50" 0.368984476349064 0.789246419666677 0.941413184931501 0.516099191457467 0.935223699073303 0.590171823252754 0.368695673656575 0.913948248824328 0.97005234706208 "NRAS MUT" "PF.4708671_IC_50" 0.756625558644787 0.934762260113025 0.0722889460719631 0.51613338112664 0.935223699073303 -0.155480131860164 0.750495995215651 0.968780465757047 -0.0874028297272459 "KDM5C MUT" "Sorafenib_IC_50" 0.638306183295369 0.895624997957207 0.504604085034017 0.516136921542609 0.935223699073303 0.665072321024127 0.673904147189951 0.960256725054738 0.462213338191842 "FLCN MUT" "Etoposide_IC_50" 0.0488369617791695 0.393576277278407 2.16354536568456 0.516260847142094 0.935223699073303 0.464179088292126 0.399844441213633 0.916480913435499 1.1271397292973 "SMARCB1 MUT" "Etoposide_IC_50" 0.440224107913992 0.824500931653809 -1.33865698965517 0.516302159969181 0.935223699073303 -0.731163134924414 0.311947611933725 0.898149383211927 -1.68105070960158 "CCND1 MUT" "JNK.Inhibitor.VIII_IC_50" 0.945093149959572 0.990147156460271 0.0161241673306776 0.516315932502692 0.935223699073303 -0.146182732181757 0.737700374301625 0.96672489654949 -0.0853370381553978 "FAM123B MUT" "ZM.447439_IC_50" 0.0808620257141722 0.493903473430236 1.61316317482063 0.516560602128104 0.935436898082072 0.476849705255006 0.26990090927446 0.878819138279722 0.970642321974734 "MSH2 MUT" "Embelin_IC_50" 0.204647379029064 0.676395003035772 -0.690079716791988 0.516665351191343 0.935436898082072 -0.283964582241043 0.108914006125758 0.794794813806788 -0.870551223930702 "MS-HL MUT" "X681640_IC_50" 0.157321691160093 0.632778052170647 -0.319613247239929 0.516749625266371 0.935436898082072 -0.125700929194214 0.373235344258898 0.913948248824328 -0.204099361280905 "FGFR3 MUT" "Bortezomib_IC_50" 0.476560979209721 0.835743387252806 -1.13673773809524 0.51689531601008 0.935509945279299 0.839482700876598 0.398687861054021 0.916480913435499 -1.28399313048775 "KDM5C MUT" "Tipifarnib_IC_50" 0.566257311427534 0.872389778906173 0.644176109947654 0.517046261834523 0.935542114617287 0.484125686498487 0.461727594457086 0.929276781658587 0.810557220251795 "MET MUT" "GDC0941_IC_50" 0.292025399149679 0.746611418788718 0.643511588194438 0.51712377442363 0.935542114617287 0.319671253933616 0.459191314645298 0.927632358897555 0.44619024522698 "SMAD4 MUT" "Bosutinib_IC_50" 0.323965491667396 0.765579672794663 0.350086468074074 0.517497629177448 0.935586206915037 0.193747830999817 0.358232544808848 0.91161229252998 0.320509813078798 "MSH6 MUT" "Imatinib_IC_50" 0.326348162815856 0.768371695113365 -0.686626322033893 0.517513587859494 0.935586206915037 -0.446392264309715 0.372973613511068 0.913948248824328 -0.654151926035884 "MLH1 MUT" "S.Trityl.L.cysteine_IC_50" 0.05982423585844 0.4412782713113 1.40350811458333 0.517533522940469 0.935586206915037 0.266955398198213 0.054379959726793 0.697305726351784 1.48130053356797 "KIT MUT" "ABT.888_IC_50" 0.478623981490538 0.836304203722611 0.375882984703632 0.51786684617666 0.935586206915037 0.290020546755275 0.725787589959343 0.965402608571648 0.175486642518811 "MSH2 MUT" "Cyclopamine_IC_50" 0.382283990371964 0.798569876743396 -0.582235709342559 0.518053526525515 0.935586206915037 -0.397275370503535 0.639824079703262 0.954844169357195 -0.317145001095339 "MS-HL MUT" "BIRB.0796_IC_50" 0.687133237412554 0.911748124009352 0.0657511494252847 0.518161381438473 0.935586206915037 0.101147000617007 0.225709534564298 0.86643108387559 0.214349722763258 "MAP2K4 MUT" "Lenalidomide_IC_50" 0.866438449282102 0.967996000759365 -0.0521324790457776 0.518253032070785 0.935586206915037 -0.175726631319613 0.605886587735352 0.949657634568742 -0.169705056206423 "FBXW7 MUT" "A.443654_IC_50" 0.0704522903848304 0.469481816691404 -1.23848637011227 0.518315996573765 0.935586206915037 -0.291686764232595 0.0513524265362864 0.689395114310948 -1.39776146518436 "FLT3 MUT" "Sunitinib_IC_50" 0.0173279239425971 0.241205787671168 -3.23988110238904 0.518401229812167 0.935586206915037 -0.659437753810253 0.125273141334497 0.817150972850516 -1.84159611625802 "FGFR3 MUT" "Shikonin_IC_50" 0.397249973200342 0.805474203651196 -1.00208726424869 0.518409694710023 0.935586206915037 -0.642978228098865 0.369339967502546 0.913948248824328 -1.03354299448562 "PTEN MUT" "WO2009093972_IC_50" 0.00453423492837163 0.113432508165827 -0.614186210180623 0.518515497000615 0.935586206915037 -0.129512579778407 0.202661621679766 0.852959543285214 -0.297833607548367 "SMARCB1 MUT" "Vinorelbine_IC_50" 0.402248808292216 0.806950907260711 -1.20098485344828 0.518749336763198 0.935586206915037 -0.677917692238691 0.219578758122456 0.862485161824651 -1.75007018337041 "FAM123B MUT" "DMOG_IC_50" 0.953407934784096 0.992679871625456 -0.0469721317157711 0.518892249881695 0.935586206915037 -0.466122273756161 0.197169299606872 0.851001889249827 -0.990769252623882 "FGFR3 MUT" "Vinorelbine_IC_50" 0.65938050904042 0.902400992643984 -0.516570492227969 0.518948208805185 0.935586206915037 0.554184113175886 0.695801545920559 0.961100601384891 -0.448956016031021 "PDGFRA MUT" "BIRB.0796_IC_50" 0.533955186078689 0.858279561609675 0.339788084291186 0.519167638772063 0.935586206915037 0.337748817149332 0.465711055631493 0.929276781658587 0.400042646421624 "CCND1 MUT" "Gemcitabine_IC_50" 0.177252096555898 0.656513564381252 1.07704638087542 0.519181269197202 0.935586206915037 0.347052873909598 0.504628019093079 0.93503055238173 0.535235909140675 "CDKN2C MUT" "Bexarotene_IC_50" 0.450007380620492 0.827950185889909 0.386964654320986 0.519223805834267 0.935586206915037 0.295501422679908 0.379627140267901 0.915134825237766 0.512970935820574 "STK11 MUT" "Rapamycin_IC_50" 0.663763996936017 0.903538553756266 -0.591362715254236 0.5193119057802 0.935586206915037 -0.753983888035392 0.589053946379396 0.949294892873838 -0.848135860351872 "ERBB2 MUT" "CCT007093_IC_50" 0.930633905167373 0.986689293492114 -0.0224219758064518 0.519329280826241 0.935586206915037 0.172243642899625 0.456000469174613 0.925809648901546 0.207288369131287 "RUNX1 MUT" "CCT007093_IC_50" 0.586908580715458 0.876506729771444 0.318416778523488 0.519342665055149 0.935586206915037 0.377446392673426 0.582063023658155 0.949294892873838 0.323411685270595 "MLH1 MUT" "Z.LLNle.CHO_IC_50" 0.335565790339012 0.773264085106582 0.626145496527774 0.519710449553522 0.935586206915037 0.389438219176245 0.207062401096604 0.853446327418758 0.810269431412428 "KDM5C MUT" "Salubrinal_IC_50" 0.584654296079604 0.876506729771444 0.545444977168943 0.519716768076531 0.935586206915037 0.531075428069355 0.552598387544543 0.94744222663987 0.584619123369438 "VHL MUT" "OSI.906_IC_50" 0.757683425416574 0.934762260113025 -0.223885726713532 0.520032277975123 0.935586206915037 -0.444268095932133 0.608218146907289 0.949812794563677 -0.404962860534055 "MLLT3 MUT" "XMD8.85_IC_50" 0.460978923339119 0.828966839128293 -0.431675070422535 0.520174234496568 0.935586206915037 -0.323128847819183 0.605564257188222 0.949657634568742 -0.314124409909625 "PIK3R1 MUT" "Methotrexate_IC_50" 0.276276641417547 0.735108059249974 0.859173592799199 0.520255450784283 0.935586206915037 0.385424718417156 0.360682410633202 0.91161229252998 0.569646472246519 "CDK6 MUT" "CGP.082996_IC_50" 0.293354643498933 0.747036827777118 0.996498031854382 0.520277844402064 0.935586206915037 0.510446706228106 0.584098539967882 0.949294892873838 0.628449417340331 "CCND3 MUT" "FH535_IC_50" 0.677619998108756 0.908720747099578 0.331589641361263 0.520395522069733 0.935586206915037 0.439885434324168 0.392093267963651 0.915926348152589 0.653838355278694 "CDH1 MUT" "Elesclomol_IC_50" 0.469189436991054 0.83190905508009 0.561532481285979 0.520482976185504 0.935586206915037 -0.419450773159627 0.57714940164189 0.949294892873838 0.439385374023854 "MET MUT" "NVP.TAE684_IC_50" 0.204080524123016 0.675781408528279 2.20912890604025 0.52051878019104 0.935586206915037 0.912753337466564 0.12892207774068 0.820169751013594 2.64791227222568 "FLCN MUT" "WO2009093972_IC_50" 0.691161805409626 0.912932803156675 -0.434009963133643 0.52057233110498 0.935586206915037 -0.630169790476817 0.637475166521518 0.953260978932076 0.715958793519765 "CCND3 MUT" "BX.795_IC_50" 0.874297975494153 0.971134508019394 -0.179070275303645 0.520604803237166 0.935586206915037 -0.560878933842886 0.928645969989135 0.994186152404781 -0.0888225855079484 "MYCN MUT" "CEP.701_IC_50" 0.439944794659161 0.824500931653809 -0.333107432817335 0.520659510568256 0.935586206915037 -0.211389034269364 0.312849448712698 0.899454824868071 -0.462971166683006 "FGFR3 MUT" "VX.702_IC_50" 0.682693385300439 0.910084943794605 -0.43396433206108 0.520699839780923 0.935586206915037 -0.556346810776064 0.321199736426395 0.900918773778407 -0.976035169299772 "CDK6 MUT" "Vorinostat_IC_50" 0.139756690854336 0.609482385765814 0.627973477045909 0.520729942661978 0.935586206915037 0.208372673344246 0.369068714561087 0.913948248824328 0.347888599230653 "FGFR2 MUT" "Roscovitine_IC_50" 0.0559999075689955 0.42507280266688 1.84907427912342 0.520957790578746 0.935806257712347 0.564730546129507 0.1650266940577 0.84067330207935 1.64099012637951 "KDM5C MUT" "Axitinib_IC_50" 0.214333365454442 0.688117861819268 -1.56331116318785 0.521324764493706 0.936013240619932 -0.686622213031976 0.132348704018445 0.824834273956355 -1.65023700087746 "MLLT3 MUT" "AS601245_IC_50" 0.922719559230325 0.98643792569589 -0.038846449982871 0.521346630371152 0.936013240619932 0.204926679156164 0.968924209468439 0.997173634484198 0.0161107556308736 "MLLT3 MUT" "Tipifarnib_IC_50" 0.787279075510545 0.946449577332088 -0.134289002740666 0.521389201818129 0.936013240619932 0.211026953333766 0.807354700171083 0.977383317127464 -0.124750325587725 "BRAF MUT" "JW.7.52.1_IC_50" 0.24902323525582 0.715488629021978 -0.701179870600416 0.521616840321228 0.936215309605815 -0.258991673924878 0.424219292471385 0.922428741067589 -0.636761324669059 "MLLT3 MUT" "Cisplatin_IC_50" 0.677067171568925 0.908720747099578 -0.161343541073271 0.521757353380613 0.936215309605815 -0.215188295129043 0.531697813601407 0.94320946427311 -0.243205985341925 "CDK6 MUT" "LFM.A13_IC_50" 0.359338733301365 0.786601117838604 0.360801669595783 0.521932009923477 0.936215309605815 0.238340722010947 0.633528048886034 0.952523560833852 0.199857510508712 "KDR MUT" "PD.173074_IC_50" 0.490250499785825 0.84263880174142 0.57536151337247 0.521942878001863 0.936215309605815 0.456263868009954 0.203360936098749 0.852959543285214 0.985528597288291 "MYC MUT" "CMK_IC_50" 0.832638797300078 0.958751873919626 -0.0768528651960784 0.522028849585407 0.936215309605815 -0.21732086462701 0.821107637550727 0.977383317127464 -0.0893543715811858 "MET MUT" "Cyclopamine_IC_50" 0.914840904324044 0.984454388864878 -0.112166780821917 0.522316683561429 0.936385952247351 -0.612327493977301 0.902730649407952 0.988746233284632 -0.128634868037428 "RB1 MUT" "CGP.082996_IC_50" 0.790737218892889 0.94790644179192 0.0715924414008641 0.522334873036074 0.936385952247351 0.149502777708926 0.117831867042886 0.806213259790349 -0.487928909586663 "TSC1 MUT" "ABT.263_IC_50" 0.702201719338856 0.915500829364901 -0.589303396484367 0.522531265415645 0.9364459588775 0.888172980461108 0.788377852345361 0.975265472692061 0.358549194318404 "FGFR2 MUT" "Epothilone.B_IC_50" 0.00105989018281561 0.0473009282089722 3.81677101570684 0.522869881944316 0.9364459588775 -0.432237572852088 0.0237815750497669 0.568899552891211 2.97014780630753 "CDK6 MUT" "Bicalutamide_IC_50" 0.492638414572057 0.842990705166559 0.151504160808436 0.523309038387374 0.9364459588775 0.134175461184832 0.162042219762241 0.839927262232576 0.309172363910751 "PIK3R1 MUT" "BIRB.0796_IC_50" 0.764687579673736 0.936715916563097 -0.129669123314064 0.52351800265621 0.9364459588775 -0.264376829195254 0.765137847943422 0.969901216545994 -0.12751303637715 "KDM5C MUT" "OSI.906_IC_50" 0.524613483174699 0.854725328793752 -0.650579172774879 0.523585466987704 0.9364459588775 -0.617675609196656 0.469533851412679 0.929276781658587 -0.740200793949295 "KDM5C MUT" "JW.7.52.1_IC_50" 0.633106894802739 0.89399270048764 -0.646330268771332 0.523646423384058 0.9364459588775 0.525532155907851 0.592180218120602 0.949294892873838 -0.733504183665923 "CDK6 MUT" "Bexarotene_IC_50" 0.309987101685911 0.757046299071613 0.580321716168719 0.523744814333662 0.9364459588775 0.324959968385904 0.493930124721238 0.933639405738697 0.399511938680771 "MDM2 MUT" "CI.1040_IC_50" 0.200290334056566 0.674012093366938 0.730636102713176 0.523777403666507 0.9364459588775 0.325659175367651 0.19820285628171 0.851001889249827 0.643614605918244 "IDH1 MUT" "GDC.0449_IC_50" 0.626943158723891 0.89123540333742 -0.420720328185327 0.523799153663376 0.9364459588775 -0.48873337544455 0.615694128332892 0.950126768674963 -0.433375680289231 "FGFR3 MUT" "Sorafenib_IC_50" 0.851359218213546 0.963639744191413 0.245980172881357 0.52384293882053 0.9364459588775 0.793520341595117 0.746419914030875 0.968371047127272 0.438528445963518 "MDM2 MUT" "GW843682X_IC_50" 0.327250879639043 0.769477114660932 -1.07669227054794 0.523881604586416 0.9364459588775 -0.361382237384442 0.472275238625254 0.929276781658587 -0.819846531183128 "NF1 MUT" "Lenalidomide_IC_50" 0.106889949716122 0.551794991672845 0.372278608570914 0.524016339079651 0.9364459588775 0.129895453583076 0.288670625587211 0.889281028047524 0.249635346487134 "CTNNB1 MUT" "BMS.509744_IC_50" 0.605419743730651 0.882603260686518 -0.369015910652923 0.524217099566614 0.9364459588775 0.335735188937755 0.643867504895716 0.956058737832946 -0.360655255505512 "APC MUT" "CGP.082996_IC_50" 0.545055217634836 0.862633715268747 -0.304086988835722 0.524332949999475 0.9364459588775 -0.276061866752252 0.689910007173236 0.961100601384891 -0.235005703767005 "KDM5C MUT" "AUY922_IC_50" 0.677909354305758 0.908720747099578 -0.394556521815015 0.524368083274046 0.9364459588775 -0.407407842678399 0.576634570743451 0.949294892873838 -0.504986861608069 "FGFR3 MUT" "Doxorubicin_IC_50" 0.578093722624966 0.873750949722175 -0.627717757839716 0.524369529155306 0.9364459588775 0.447061619646259 0.608661147105817 0.94989603148139 -0.548474629481484 "JAK2 MUT" "Paclitaxel_IC_50" 0.663431568600571 0.903532550336094 -0.657609952380959 0.524385527915765 0.9364459588775 -0.415290857092115 0.867263693510306 0.987077901072027 0.311518891182343 "MSH6 MUT" "JNJ.26854165_IC_50" 0.655918878822333 0.90173615523547 -0.254899279279281 0.524473887346399 0.9364459588775 -0.338854550220882 0.45241543150115 0.925809648901546 -0.405964997163517 "FLCN MUT" "GDC.0449_IC_50" 0.96586252057798 0.994434372972651 0.0262497480620153 0.52489265289146 0.9364459588775 -0.347043334553888 0.818273306929513 0.977383317127464 -0.196879066692852 "EWS_FLI1 MUT" "Sorafenib_IC_50" 0.990925510540825 0.998036562927507 -0.00646573076923099 0.5249093072828 0.9364459588775 -0.372946529177955 0.77891446642839 0.972337708041191 0.18867132782394 "MET MUT" "Vinblastine_IC_50" 0.0320557269211656 0.329610399195976 1.1158823974855 0.524939020519528 0.9364459588775 0.240199158387612 0.207347907873775 0.853446327418758 0.616182959208068 "FLCN MUT" "Bexarotene_IC_50" 0.753867243933353 0.933869109446012 0.226198284965035 0.525014725639861 0.9364459588775 -0.408248261837189 0.92387128826849 0.993978204254811 -0.0846449121786173 "NOTCH1 MUT" "BMS.509744_IC_50" 0.462340438499021 0.82931728663973 -0.375030456140353 0.52508021162344 0.9364459588775 0.253172664445955 0.724489240722073 0.965402608571648 -0.203918816401723 "JAK2 MUT" "S.Trityl.L.cysteine_IC_50" 0.569814419422922 0.872389778906173 -0.688032001137651 0.525094934237058 0.9364459588775 -0.416354413670666 0.998758790593675 0.999751228014461 0.00236722236987093 "MS-HL MUT" "Mitomycin.C_IC_50" 0.160137657585914 0.636336191287136 -0.399009251939979 0.525135981616864 0.9364459588775 0.143065531240535 0.666528000852085 0.959230524020512 -0.132666172551619 "FLT3 MUT" "QS11_IC_50" 0.1257597461235 0.586978030371663 -1.50500763001748 0.525159679566777 0.9364459588775 -0.464419983874075 0.265957828437499 0.877052916121269 -1.07493762291933 "IDH1 MUT" "JNK.9L_IC_50" 0.458934012429982 0.828966839128293 -0.720356384482765 0.525215327234414 0.9364459588775 -0.481299315502478 0.449333860199849 0.925809648901546 -0.734313607245608 "CDK4 MUT" "Epothilone.B_IC_50" 0.919464772090889 0.985846509832088 -0.0840259059753949 0.525330920988836 0.936464052449188 0.301870451503485 0.9761701283779 0.99742775226181 0.0257034368008557 "CDKN2C MUT" "SB.216763_IC_50" 0.777351702923046 0.941790749776385 -0.146630182445759 0.525600774504551 0.936757069712005 -0.319402753028155 0.795244992934061 0.975627957210581 -0.139065828098274 "MYCN MUT" "A.443654_IC_50" 0.043679789780676 0.374825086237107 0.922964742164503 0.525800671968341 0.936925314556749 0.1945247694587 0.530929930192342 0.94320946427311 0.35400666169788 "EZH2 MUT" "AZD.2281_IC_50" 0.987066449860156 0.997512191762409 0.0121848913043477 0.526246673792021 0.937286304902845 0.35728247969953 0.814343431387414 0.977383317127464 0.154823456567333 "KIT MUT" "AZ628_IC_50" 0.306773744586389 0.755024525457845 -1.95487696938776 0.526473245167437 0.937286304902845 -0.937136575738698 0.787973083145245 0.975265472692061 0.448600195901858 "MAP2K4 MUT" "BAY.61.3606_IC_50" 0.723528333008922 0.923974852378165 0.189691920621929 0.526513966982426 0.937286304902845 0.236259137829243 0.706958297416689 0.962630898212352 -0.208125847126153 "NRAS MUT" "MG.132_IC_50" 0.254594609799553 0.720081124085933 -0.596089776021082 0.526548815872321 0.937286304902845 -0.304698130559755 0.647420600204376 0.957449344088104 -0.250639766864541 "APC MUT" "VX.680_IC_50" 0.692658358528279 0.913066921534475 -0.3192741030303 0.526586002250698 0.937286304902845 -0.341465361729942 0.835544616653277 0.981626636221501 0.205272699560667 "BRCA1 MUT" "BMS.536924_IC_50" 0.578225050630226 0.873750949722175 -0.974806603389826 0.526703965374846 0.937286304902845 -0.81728162759384 0.318256020729392 0.900918773778407 -1.68073179647848 "CDKN2A MUT" "PF.4708671_IC_50" 0.463699972093633 0.829490249358073 0.0814134855020367 0.526742027673697 0.937286304902845 0.0720706793816743 0.962531490758707 0.996771409852636 0.00598800907621705 "NF1 MUT" "Paclitaxel_IC_50" 0.263777895608994 0.726391159970069 0.856800785964916 0.526997269344037 0.93739386628265 -0.21273191593825 0.894003794195374 0.988301482344111 0.117932617422132 "FGFR3 MUT" "ATRA_IC_50" 0.671059509410999 0.906916702390321 0.51898397900765 0.527062773089427 0.93739386628265 0.608301233760606 0.793434013649057 0.975393509832241 -0.279744401826888 "KIT MUT" "RO.3306_IC_50" 0.260009518374746 0.723189643810247 -0.830513254901963 0.527119127149595 0.93739386628265 -0.445504800099363 0.232900992849445 0.869962136993019 -0.88591723994284 "MLL_AFF1 MUT" "PLX4720_IC_50" 0.168007875021945 0.647446641789 -1.84462306309752 0.527617843500929 0.937903024801914 -0.76281814115801 0.393355220576911 0.915926348152589 -1.04936975099172 "MLL_AFF1 MUT" "KU.55933_IC_50" 0.441717666075693 0.825166478070376 -0.68392317554241 0.527670352813737 0.937903024801914 0.511114502617861 0.997884717392522 0.99968575015939 0.00236360986226985 "CDKN2a(p14) MUT" "AKT.inhibitor.VIII_IC_50" 0.276876079066678 0.735108059249974 -0.150376641289428 0.527814894008432 0.937903024801914 0.07840402784156 0.531225856390451 0.94320946427311 -0.0946100220203994 "MLH1 MUT" "Camptothecin_IC_50" 0.884526430626979 0.974262585935532 0.0994384368199359 0.52782787050557 0.937903024801914 0.275831377613943 0.196846192206615 0.851001889249827 0.785899164856323 "SMO MUT" "CCT018159_IC_50" 0.686393669439243 0.911730003936733 0.404742694063929 0.528287551886857 0.93814759320035 0.586203916256151 0.714905591898318 0.962630898212352 0.36786489426572 "EWS_FLI1 MUT" "Vinblastine_IC_50" 0.00941629594850587 0.171014569158856 -1.25249427850211 0.52840704853943 0.93814759320035 -0.234260349401123 0.943513072142105 0.995314665488626 0.0371496933348642 "MAP2K4 MUT" "DMOG_IC_50" 0.714842506856007 0.920308547391321 0.183427037988373 0.528565245794254 0.93814759320035 0.284523068715295 0.572688080435791 0.949294892873838 -0.293660688469933 "ALK MUT" "Cytarabine_IC_50" 0.0636170308402694 0.452348159241339 -2.60287801518026 0.528573549987392 0.93814759320035 -0.674026751160108 0.0268340651136251 0.588427980923714 -2.89074029040586 "KDM6A MUT" "MG.132_IC_50" 0.740562236390357 0.929570057037101 0.222007622132255 0.528743650094373 0.93814759320035 0.373796454006771 0.587184236805468 0.949294892873838 0.371722167094253 "GNAS MUT" "X681640_IC_50" 0.0721039756372006 0.474889173046706 1.04381159034906 0.528855772343537 0.93814759320035 0.312522653336917 0.213933617705755 0.859314544932072 0.676721571273261 "FLT3 MUT" "BMS.754807_IC_50" 0.897811213538217 0.978288534071451 0.14834329057592 0.528902604123188 0.93814759320035 0.613875846172029 0.602701303019896 0.949657634568742 -0.593620154675714 "PTEN MUT" "WZ.1.84_IC_50" 0.962363729335583 0.994039576672403 0.012467486559139 0.528935641423987 0.93814759320035 0.140747591733532 0.746824656112417 0.968538225895791 0.0875412956420559 "SMAD4 MUT" "CGP.082996_IC_50" 0.0689925572361918 0.465594909433601 -1.13461466633712 0.528955625092002 0.93814759320035 -0.343638392688259 0.0934907609297105 0.768046723169691 -1.09436900666796 "CDK4 MUT" "Bryostatin.1_IC_50" 0.9173377335646 0.984975746996111 -0.0465834874780319 0.529036655662889 0.93814759320035 0.267608753752541 0.937280368303333 0.994831655017307 -0.035815081320962 "RUNX1 MUT" "Docetaxel_IC_50" 0.626892191965433 0.89123540333742 -0.508682563507415 0.529217277683141 0.93814759320035 0.49337835745832 0.861508389809027 0.985524480087535 -0.174489841851211 "RB1 MUT" "NVP.TAE684_IC_50" 0.978366403231184 0.996276778834563 0.0109689713148132 0.529233131621862 0.93814759320035 -0.217868804475239 0.265245362825135 0.877052916121269 -0.527662004508011 "MYC MUT" "NSC.87877_IC_50" 0.340037340334573 0.778500909061878 0.167406590064212 0.529359234288398 0.938183867434696 0.109322938908292 0.434135501288941 0.922569292988365 0.147182969354217 "NF1 MUT" "CI.1040_IC_50" 0.734623600593016 0.928710633005918 0.13499175379538 0.529616735101388 0.938239118177785 -0.224907368194944 0.657814322240801 0.958313128388245 -0.16581423528201 "FAM123B MUT" "AUY922_IC_50" 0.431086733054366 0.820918238409269 0.669463952797211 0.529720166922914 0.938239118177785 0.359268091119364 0.624160516689325 0.950496524771391 0.403631448006192 "JAK2 MUT" "PF.02341066_IC_50" 0.440388347783713 0.824500931653809 0.727816636363627 0.529758202666401 0.938239118177785 0.54544563393468 0.589786604515856 0.949294892873838 0.615380170656996 "ERBB2 MUT" "AG.014699_IC_50" 0.0795231156236244 0.490447770731534 0.640835766203706 0.529812991516901 0.938239118177785 0.210558039375029 0.762997100994249 0.969901216545994 0.109094741133264 "CDH1 MUT" "GNF.2_IC_50" 0.963561005590311 0.994159243759316 0.0258350068728524 0.530447690497306 0.939042465678401 0.346187040217577 0.61345320305031 0.949969990634665 0.297718607731916 "CCND1 MUT" "Bortezomib_IC_50" 0.823224510233212 0.957106429492329 -0.161819968531467 0.530572454848943 0.939042465678401 -0.376256188845852 0.755828403510347 0.969901216545994 0.253862091004172 "NOTCH1 MUT" "KU.55933_IC_50" 0.896030296960964 0.977117518088203 -0.0523850300601199 0.530720360216658 0.939042465678401 0.230367240358933 0.536742246160244 0.943443271455699 0.26275992089013 "MLH1 MUT" "Pazopanib_IC_50" 0.760573543290666 0.93574319967042 0.167496067256639 0.530732627011475 0.939042465678401 0.296735169633845 0.948210915022411 0.995668765770473 0.0328284897226458 "BRCA1 MUT" "CI.1040_IC_50" 0.808972217283158 0.952641225877339 -0.216971793103445 0.530828150918614 0.939042465678401 -0.505262873612983 0.591206932723867 0.949294892873838 -0.423309888482658 "SMARCA4 MUT" "OSI.906_IC_50" 0.618173824476527 0.88687184464302 -0.309255690009639 0.530978935635627 0.939042465678401 -0.365992303608135 0.875026476802004 0.98777404048288 -0.110163710580062 "MAP2K4 MUT" "VX.680_IC_50" 0.997257600464019 0.998981694467749 -0.00524403299203635 0.531006785568847 0.939042465678401 -0.621842873652962 0.618231051687913 0.950394619652337 0.95616019418752 "STK11 MUT" "LFM.A13_IC_50" 0.393791273120038 0.803073858340542 0.196588720614829 0.531276245848241 0.939068977682597 0.136157504641871 0.204565636475983 0.853446327418758 0.309711470078842 "SETD2 MUT" "PF.4708671_IC_50" 0.905309241704695 0.980799080670852 0.0990559417040342 0.531318972374957 0.939068977682597 0.518988563193993 0.992629105731125 0.999469155159075 0.0078064606109096 "KRAS MUT" "AP.24534_IC_50" 0.149736418205649 0.62466549367193 0.47461010234146 0.531338994804082 0.939068977682597 0.196688492020893 0.346717521807842 0.9093911137553 0.33407725932917 "EGFR MUT" "SL.0101.1_IC_50" 0.289259080983859 0.745006207420441 -0.280791689348577 0.531644270347784 0.939184510466533 -0.145214183449569 0.22604670885483 0.86643108387559 -0.323233208906036 "CDH1 MUT" "CGP.60474_IC_50" 0.791583060120265 0.947957006058263 0.221683560137458 0.531762145423736 0.939184510466533 0.400434725515875 0.537874065279823 0.943670401768097 0.515923401886973 "NF2 MUT" "FTI.277_IC_50" 0.0755713991330365 0.480779116570693 -0.434624450725744 0.531784988904419 0.939184510466533 -0.140682432002173 0.56562828111342 0.949294892873838 0.143888649873152 "CDK6 MUT" "BIRB.0796_IC_50" 0.25618637318177 0.720311238267775 0.463924882024879 0.531827373396712 0.939184510466533 0.244399618670953 0.428209547111022 0.922428741067589 0.319813863880259 "MLLT3 MUT" "Sorafenib_IC_50" 0.560067652234581 0.869754268118204 0.346748783972127 0.531990226089908 0.939285327615203 0.350790462825224 0.295019934085967 0.894167310052 0.677363858177295 "KIT MUT" "Bleomycin_IC_50" 0.775932248129172 0.941591338606299 -0.421646342657346 0.532104268426541 0.939299941939199 0.759066276320879 0.993312784578711 0.999469155159075 -0.0119878580709986 "NF2 MUT" "AZD7762_IC_50" 0.970982234609632 0.995220468612913 -0.0144795819687558 0.532252769884097 0.93937536751603 0.195862243352429 0.594647816431679 0.949294892873838 0.206063394351535 "SMO MUT" "GSK.650394_IC_50" 0.184158497629984 0.660385845878234 -1.95627160347827 0.532607436717986 0.939597939631452 -0.591785877348647 0.137113663150883 0.831473272394224 -2.17000408727348 "FLCN MUT" "BAY.61.3606_IC_50" 0.043305773410536 0.374123126127403 1.73200294405594 0.532705958282029 0.939597939631452 0.371726271698315 0.00952904888758486 0.433987093182775 2.67781664489052 "STK11 MUT" "GSK.650394_IC_50" 0.255203300463277 0.720311238267775 0.493455061181438 0.532801841334461 0.939597939631452 0.175318381370402 0.353906898943761 0.911252930312559 0.425989998431155 "EZH2 MUT" "Thapsigargin_IC_50" 0.90183567469152 0.979694707150557 -0.134973387969927 0.53293494816637 0.939597939631452 -0.518426691739531 0.702962225945572 0.962139809888331 -0.436584391785775 "MDM2 MUT" "Bortezomib_IC_50" 0.649471156229533 0.898715072993842 -0.461502731958764 0.532995320262696 0.939597939631452 0.514629496361582 0.876086055856216 0.987838063957761 0.150852248211963 "APC MUT" "Nutlin.3a_IC_50" 0.157800479581471 0.633503899390536 0.495404626721765 0.5330136718684 0.939597939631452 0.21091136109928 0.26544215966107 0.877052916121269 0.46304926837657 "TSC1 MUT" "GDC.0449_IC_50" 0.834889643542139 0.959122768755193 0.180441833976834 0.533141809328415 0.939637310705627 0.481286176303412 0.495887521322986 0.933639405738697 0.583713005969184 "NF1 MUT" "MG.132_IC_50" 0.674085485063431 0.908418658675584 0.272181363179076 0.533548669817091 0.939889893420077 0.358244300251746 0.970082239277938 0.997173634484198 0.0255707209436546 "EZH2 MUT" "PD.0332991_IC_50" 0.433959909476311 0.823150425912549 -0.774040297101437 0.533597697127476 0.939889893420077 -0.488427390695067 0.275855229191565 0.883780956691668 -1.0063418953189 "CDH1 MUT" "WZ.1.84_IC_50" 0.988666391672182 0.998036562927507 -0.0107351890034373 0.533675890115208 0.939889893420077 0.400441003936051 0.646426027528693 0.957449344088104 0.337723148803896 "MET MUT" "CGP.60474_IC_50" 0.353594019325617 0.785062892590933 1.22331857142857 0.533798069383997 0.939889893420077 0.607436848363818 0.194662568847427 0.851001889249827 1.66531545421501 "JAK2 MUT" "PD.0325901_IC_50" 0.293599953888494 0.747036827777118 0.968529936127747 0.53401251608332 0.939889893420077 0.53887014299179 0.620593330442933 0.950496524771391 0.441134072625519 "CDK6 MUT" "AUY922_IC_50" 0.958755878850263 0.993432616972253 -0.0348644336555367 0.534061016501714 0.939889893420077 -0.281596449505719 0.770189792755765 0.969901216545994 0.201216183970027 "BRCA2 MUT" "AZD.0530_IC_50" 0.56978375175285 0.872389778906173 0.815146367003357 0.534362745206981 0.939889893420077 -0.77612471812444 0.549477270050891 0.947060194029534 0.819106824157919 "EGFR MUT" "Rapamycin_IC_50" 0.240659217017383 0.711340033600749 1.13718137586207 0.534372636647842 0.939889893420077 0.512746027543418 0.070627494436735 0.728378470923167 1.79236844302207 "MLLT3 MUT" "PD.0332991_IC_50" 0.808884603446837 0.952641225877339 -0.125026082627117 0.534469062734554 0.939889893420077 0.255829306406393 0.819572996263198 0.977383317127464 0.11755400591178 "MS-HL MUT" "GW843682X_IC_50" 0.855360786474725 0.964997350696397 0.0755580272373543 0.534524126049781 0.939889893420077 -0.133850322628482 0.868940888433552 0.98751437004641 0.080495193439414 "CDK4 MUT" "Docetaxel_IC_50" 0.513933449383438 0.85130999259055 0.396625708197432 0.534565789706183 0.939889893420077 -0.282880708405491 0.454192970011714 0.925809648901546 0.461565382836208 "BCR_ABL MUT" "BAY.61.3606_IC_50" 0.691304256415791 0.912932803156675 -0.38083585689355 0.534808232515423 0.939889893420077 0.427104274197937 0.262165076437557 0.877052916121269 1.02914563889528 "EZH2 MUT" "SL.0101.1_IC_50" 0.89361986016265 0.976022725555062 0.0731316988416977 0.534909360737759 0.939889893420077 0.29464454370002 0.921308894991353 0.993931766508607 0.0517730136934962 "NF1 MUT" "Bicalutamide_IC_50" 0.391748903583597 0.802844410532843 0.113021263537907 0.534935814203413 0.939889893420077 0.0785243284002159 0.829556651114035 0.98125900619922 0.0288159931334154 "TET2 MUT" "Elesclomol_IC_50" 0.997107094739649 0.998981694467749 0.0045726787072237 0.535293542548628 0.939889893420077 0.658440648766078 0.860100668426186 0.985492715300343 0.258294523553878 "CDK4 MUT" "Paclitaxel_IC_50" 0.55470163926 0.867243358863332 -1.0912828 0.53550146302775 0.939889893420077 -0.503103878707455 0.80036817579101 0.976360691959787 -0.469352229821958 "FBXW7 MUT" "Epothilone.B_IC_50" 0.693685578091731 0.913368820021033 -0.199840705651104 0.535572766557208 0.939889893420077 0.180700067956566 0.89875166288552 0.988599284971277 -0.065523084780335 "PIK3CA MUT" "BI.2536_IC_50" 0.854038290615209 0.964541653680809 -0.118342194474539 0.53565431098506 0.939889893420077 -0.236657684061457 0.591184430990713 0.949294892873838 -0.392495572447075 "SMARCA4 MUT" "AZD6482_IC_50" 0.514169425302258 0.85130999259055 0.409102659090909 0.535700641365751 0.939889893420077 0.326637188029415 0.953892595307725 0.99568364368633 0.0404969779148396 "MSH2 MUT" "PF.4708671_IC_50" 0.877077219422249 0.971606616908121 0.0912787162162166 0.535812189098315 0.939889893420077 0.361134583682488 0.899996061200716 0.988704788932507 0.0752922388859915 "MLH1 MUT" "PD.0325901_IC_50" 0.101934418471724 0.542024654294532 1.17208373239437 0.53582916202636 0.939889893420077 0.425404078011248 0.163513502164396 0.839927262232576 0.885078873984317 "EGFR MUT" "BMS.708163_IC_50" 0.319320314705644 0.761311064402907 -0.276350411627906 0.535830241072527 0.939889893420077 -0.174515303372877 0.877200058555994 0.987838063957761 -0.046003733583234 "KDM6A MUT" "Imatinib_IC_50" 0.273571934141127 0.734000646544246 -0.390928696996467 0.535856312018368 0.939889893420077 -0.218826930239507 0.141367923185311 0.831473272394224 -0.60329131378906 "FLCN MUT" "TW.37_IC_50" 0.707621427744915 0.917562549248444 -0.29315413183521 0.535898180756556 0.939889893420077 -0.438228417496781 0.661464577209684 0.958689538788368 -0.400566410160316 "CCND1 MUT" "GSK269962A_IC_50" 0.391794581156327 0.802844410532843 0.669744236111117 0.535960087604142 0.939889893420077 0.460826062814287 0.933953397238672 0.994729228933513 -0.076876978932712 "CDK6 MUT" "Metformin_IC_50" 0.531134616590555 0.856734402332693 0.303178098908156 0.536036742503399 0.939889893420077 0.278975192773965 0.708114262077634 0.962630898212352 0.177496087629893 "STK11 MUT" "Salubrinal_IC_50" 0.862057175951911 0.966470069859388 -0.134800000000001 0.536357114244951 0.940016289019803 -0.396186457796563 0.949780113746897 0.995668765770473 -0.0553232232179539 "FLCN MUT" "FH535_IC_50" 0.17599700098824 0.654260931677086 0.965550414335662 0.536415184612319 0.940016289019803 0.377720521410931 0.69416275982173 0.961100601384891 0.345505277375413 "MLH1 MUT" "Methotrexate_IC_50" 0.0293885080746229 0.317131640596265 -1.61941789092142 0.536601091334462 0.940016289019803 -0.354295524051926 0.750756206734857 0.968780465757047 0.190978419623238 "EP300 MUT" "Paclitaxel_IC_50" 0.0872618697196572 0.5095152300988 -3.15211042711862 0.536700648335023 0.940016289019803 -0.495355008046012 0.114441678388683 0.799692247086917 -2.90770332426091 "NRAS MUT" "GW843682X_IC_50" 0.197599285286017 0.673916763680921 -0.695203709090907 0.536774923393122 0.940016289019803 -0.18005625138512 0.387515258220769 0.915785792511616 -0.541644938924234 "KDM6A MUT" "CHIR.99021_IC_50" 0.309259935134736 0.75674113273833 -0.324107911892031 0.536883969836644 0.940016289019803 -0.187544601483423 0.190506473612458 0.851001889249827 -0.426318909088792 "SMAD4 MUT" "JNJ.26854165_IC_50" 0.808068392301884 0.952641225877339 -0.0559166314254468 0.537001079924811 0.940016289019803 -0.136579611170216 0.248536440004482 0.875707386589409 -0.266531699067443 "NF2 MUT" "AZD8055_IC_50" 0.520051595224624 0.852599738673405 -0.203489616108173 0.537038821914759 0.940016289019803 -0.153458381863492 0.703148533909458 0.962139809888331 -0.124648804994366 "KRAS MUT" "XMD8.85_IC_50" 0.436000112044775 0.823808548892323 -0.314201661096258 0.537089930443703 0.940016289019803 -0.225573876219133 0.603071976627912 0.949657634568742 -0.227364753823441 "PIK3CA MUT" "Bortezomib_IC_50" 0.366267603894268 0.788563052166059 -0.576641792606687 0.53720840544118 0.940016289019803 -0.320846649547153 0.296313546152131 0.894167310052 -0.694436944665914 "ALK MUT" "Salubrinal_IC_50" 0.353557499933181 0.785062892590933 0.925307990867573 0.537749288609681 0.940016289019803 0.507563966617716 0.213250296413455 0.858767761815455 1.51308467466341 "KRAS MUT" "Axitinib_IC_50" 0.00140663314950145 0.0548424861786086 0.665948832090918 0.537810337871068 0.940016289019803 0.115517403840349 0.0548434369172172 0.697305726351784 0.409836569157579 "NF2 MUT" "Tipifarnib_IC_50" 0.276709772157436 0.735108059249974 -0.541053939191509 0.537823581908158 0.940016289019803 -0.205755173374129 0.516043118211517 0.939635632721979 -0.342857374092939 "GNAS MUT" "Erlotinib_IC_50" 0.779620608850062 0.942683810925913 0.242329780219779 0.538003797067727 0.940016289019803 0.482516783295905 0.332533912843402 0.903405836635744 0.84305535337453 "MET MUT" "Thapsigargin_IC_50" 0.476640046890605 0.835743387252806 -0.62334835110826 0.538068445423747 0.940016289019803 -0.412929907244337 0.422384069007285 0.922428741067589 -0.684199096796031 "MDM2 MUT" "NVP.TAE684_IC_50" 0.930352022053912 0.986689293492114 -0.0967714779661008 0.538088065944458 0.940016289019803 0.559100301226578 0.824862791774348 0.979752100273905 0.246037387780094 "TP53 MUT" "PF.562271_IC_50" 0.867749896638371 0.968516630896742 0.022415084011843 0.538264402501507 0.940016289019803 0.0709792787090105 0.677971644310122 0.96106403401727 0.0592100513283001 "FGFR3 MUT" "SL.0101.1_IC_50" 0.439905262121711 0.824500931653809 0.66573838771592 0.538437671947072 0.940016289019803 0.461717476997039 0.776166145065795 0.972337708041191 0.23485601411145 "EP300 MUT" "Sunitinib_IC_50" 0.629641118077825 0.892582202029064 -0.806453479591838 0.538485822356767 0.940016289019803 -0.758528599828787 0.547435076153397 0.947060194029534 -0.879756966572182 "MYCL1 MUT" "Embelin_IC_50" 0.459854116517307 0.828966839128293 0.337463580246917 0.538558644639279 0.940016289019803 0.22403402129673 0.56976098644114 0.949294892873838 -0.280406701655909 "CDKN2C MUT" "AICAR_IC_50" 0.8625852557053 0.966883712724823 0.105766805283756 0.538655794072666 0.940016289019803 0.337023008660097 0.447354941782997 0.925809648901546 -0.477338012927624 "MLH1 MUT" "Paclitaxel_IC_50" 0.0444493421666143 0.376863927777587 1.86973668339102 0.538688734229197 0.940016289019803 0.251317935837311 0.0459343746338356 0.672064548802462 1.88103044879437 "MET MUT" "PD.173074_IC_50" 0.242718997812054 0.712355393115946 0.512594505693119 0.538870833805717 0.940016289019803 0.231061363155887 0.818570904272171 0.977383317127464 0.0925367816283615 "KIT MUT" "NU.7441_IC_50" 0.623540809961181 0.889870791140166 -0.352475893069305 0.538964758517983 0.940016289019803 -0.388496258915959 0.750495336792264 0.968780465757047 -0.221727823528126 "CDKN2A MUT" "BMS.536924_IC_50" 0.00039519652090303 0.0254734302347722 -1.04531707804232 0.53896729426425 0.940016289019803 -0.143862248502003 0.257394823977861 0.877052916121269 -0.37026321798576 "RUNX1 MUT" "Bicalutamide_IC_50" 0.360404343479275 0.786781278801733 0.254743566433569 0.538989560154439 0.940016289019803 0.162315354101143 0.385445800477804 0.915331032347709 0.251663159936281 "STK11 MUT" "PHA.665752_IC_50" 0.563004026233676 0.871238675201477 -0.35735820338983 0.539580546875532 0.940016289019803 -0.37780115149705 0.423202992568533 0.922428741067589 0.577050268066236 "MSH6 MUT" "BI.D1870_IC_50" 0.313123784384609 0.759215564942334 -0.617369142032962 0.539616984902084 0.940016289019803 -0.323853685343715 0.311953427718928 0.898149383211927 -0.583869844526591 "CDKN2C MUT" "Salubrinal_IC_50" 0.676466008106769 0.908720747099578 0.296001787773933 0.539763796183714 0.940016289019803 0.359139064744918 0.756423008303536 0.969901216545994 0.265582955851534 "TET2 MUT" "Tipifarnib_IC_50" 0.526196004804398 0.854969048950887 -0.821224379790933 0.539808860034161 0.940016289019803 -0.535007005145216 0.561752816308309 0.949294892873838 -0.906628984986571 "ERBB2 MUT" "AICAR_IC_50" 0.979041841243407 0.996276778834563 -0.0114412276341947 0.539948217937212 0.940016289019803 -0.245793129947883 0.843988241484104 0.983349844199673 -0.0875657197938621 "CDK4 MUT" "GSK.650394_IC_50" 0.442963354715521 0.825539266593482 -0.568315355008792 0.540089018228411 0.940016289019803 -0.294788873775422 0.617484040060948 0.950247055931602 -0.390958302984911 "CDK6 MUT" "FH535_IC_50" 0.411268973845324 0.812480994891775 0.464956209578208 0.540308381966573 0.940016289019803 0.297117722239767 0.361242272196041 0.91161229252998 0.528869011490608 "NOTCH1 MUT" "GW843682X_IC_50" 0.0107369225889261 0.184249532340571 -1.82335122807018 0.540311138780769 0.940016289019803 -0.239469937654619 0.00244531238721194 0.262338505131915 -2.58014225765179 "EGFR MUT" "JNK.Inhibitor.VIII_IC_50" 0.576525170691129 0.873455460479685 -0.138946239423942 0.540376048887732 0.940016289019803 -0.146118892387814 0.530878133036355 0.94320946427311 -0.164674333838241 "MYCL1 MUT" "JNJ.26854165_IC_50" 0.555338422510584 0.867523275183957 0.302103295711055 0.540484516552993 0.940016289019803 0.291895393396264 0.518620040803914 0.939635632721979 0.354029483557169 "TET2 MUT" "BIRB.0796_IC_50" 0.155011430091493 0.630721638230745 -1.00023632315525 0.540549479910809 0.940016289019803 -0.416529295586689 0.777006901111326 0.972337708041191 -0.242641135409271 "RUNX1 MUT" "WO2009093972_IC_50" 0.331734983433778 0.772603259108552 0.866392323325645 0.540677050845068 0.940016289019803 0.488173682039465 0.319093627674034 0.900918773778407 0.869384987357723 "MLL_AFF1 MUT" "Lapatinib_IC_50" 0.996524782393237 0.998977896287767 -0.00550506896551714 0.540869838044877 0.940016289019803 -0.678653331487654 0.399242556271415 0.916480913435499 -0.938392113830555 "GNAS MUT" "Sorafenib_IC_50" 0.646232781271827 0.897186614618066 -0.427443321672356 0.540997086548339 0.940016289019803 -0.540925182672051 0.690193065439917 0.961100601384891 -0.393711651599679 "MLL_AFF1 MUT" "Vinorelbine_IC_50" 0.247062692205297 0.714668105985286 -1.65920950862069 0.541043567704461 0.940016289019803 0.654361274094181 0.437614946169946 0.922569292988365 -1.10069992942965 "NF1 MUT" "PD.173074_IC_50" 0.112290054837383 0.563432092377384 0.497894327420553 0.541049776444692 0.940016289019803 0.164718268557287 0.0796758179119853 0.741811190933953 0.549139132994463 "CDK6 MUT" "BMS.754807_IC_50" 0.2564716968236 0.720571065957101 0.929578348857649 0.54112024644343 0.940016289019803 0.419757284115933 0.373375001605116 0.913948248824328 0.764967431235373 "BRCA1 MUT" "PF.02341066_IC_50" 0.724623849698281 0.92462419671989 -0.406488117449662 0.541239391699161 0.940016289019803 -0.650090606168932 0.37962528984628 0.915134825237766 -1.00685730092922 "PDGFRA MUT" "AZD7762_IC_50" 0.950107906046792 0.991645118533501 -0.0502545570881228 0.541450102381029 0.940016289019803 0.383426000370992 0.859978501731348 0.985479880500142 -0.130923569753447 "PIK3R1 MUT" "Bexarotene_IC_50" 0.827510876498075 0.958015830101332 0.124603262741653 0.541606576035051 0.940016289019803 -0.310910789810995 0.999870208282041 0.999870208282041 -8.84915012662341e-05 "CDK6 MUT" "Sorafenib_IC_50" 0.855545266052891 0.965082879184012 -0.195453874149658 0.541638878054395 0.940016289019803 -0.620733031215777 0.77917418841786 0.972337708041191 -0.379667016330715 "TP53 MUT" "Erlotinib_IC_50" 0.783603897604896 0.944974629816073 -0.0592057694926775 0.541650017348847 0.940016289019803 -0.124349877879439 0.69320607993179 0.961100601384891 0.0906524887227954 "MAP2K4 MUT" "S.Trityl.L.cysteine_IC_50" 0.568794975759901 0.872389778906173 0.689849682593859 0.541667268016599 0.940016289019803 -0.403389362832012 0.23651682245567 0.871873900377873 1.7747760624255 "KDM6A MUT" "BMS.509744_IC_50" 0.296111571865774 0.747305163324792 -0.464743567615657 0.541773420597202 0.940016289019803 0.20206890659069 0.138836116205051 0.831473272394224 -0.703413915306689 "MLH1 MUT" "Sorafenib_IC_50" 0.403810296330884 0.80789349892196 0.553293519896197 0.541785236017426 0.940016289019803 0.389095624809579 0.151680925603738 0.832065593775825 0.990747821670087 "AKT2 MUT" "Etoposide_IC_50" 0.223594169889318 0.696139064632428 -1.13275600695653 0.541854552080338 0.940016289019803 -0.369213055962912 0.227604058130777 0.867648638924452 -1.07660058902942 "MLH1 MUT" "CGP.082996_IC_50" 0.59521572167539 0.878837476080544 0.311423576388887 0.542073044386874 0.940016289019803 -0.303706726903655 0.256054361082809 0.875707386589409 0.667559425830519 "BRCA1 MUT" "CGP.082996_IC_50" 0.530882359596748 0.856734402332693 0.727044183673471 0.542084366037859 0.940016289019803 0.593864746817842 0.527919215090471 0.942781127934541 0.733885388294583 "TSC1 MUT" "Docetaxel_IC_50" 0.486518117167017 0.84074437879216 0.890861868725865 0.542304749544224 0.940016289019803 0.586802037763475 0.604984169790153 0.949657634568742 0.637174087725989 "FLCN MUT" "CGP.082996_IC_50" 0.761575481051435 0.93574319967042 0.287983811149032 0.54234222697792 0.940016289019803 -0.484987040334195 0.452157363976207 0.925809648901546 -1.24460953617153 "PTEN MUT" "FH535_IC_50" 0.690657999959457 0.912932803156675 -0.0743134161406026 0.542363541156672 0.940016289019803 -0.0994785669613437 0.390337175719548 0.915926348152589 -0.16623312864507 "FBXW7 MUT" "AG.014699_IC_50" 0.154230948618737 0.629901298984863 0.555693665898613 0.542435742176764 0.940016289019803 0.209271289947523 0.565904519341486 0.949294892873838 0.217309201064914 "NF1 MUT" "Bryostatin.1_IC_50" 0.98437139268529 0.996723172778267 -0.00525506262753092 0.542526228288528 0.940016289019803 -0.155207334228617 0.426485409600172 0.922428741067589 -0.22049557016015 "NF2 MUT" "KIN001.135_IC_50" 0.609921652543255 0.884443710620525 -0.127506816608995 0.542529003164499 0.940016289019803 0.153763537042362 0.456077455030793 0.925809648901546 0.191919627573849 "EWS_FLI1 MUT" "Cyclopamine_IC_50" 0.503568018980403 0.846767322410355 0.303775650497917 0.54267080337534 0.940016289019803 0.276644479118378 0.731315712207162 0.96639568318693 0.17993118231602 "IDH1 MUT" "Epothilone.B_IC_50" 0.783782583174715 0.944974629816073 -0.453670918260875 0.54267126605163 0.940016289019803 0.571259087550764 0.966182545223084 0.997172246847904 -0.0687999540590242 "PIK3R1 MUT" "CEP.701_IC_50" 0.127111294337792 0.587259147140593 1.0025031271593 0.542814860462663 0.940051886434805 0.29312005493766 0.373458198101608 0.913948248824328 0.528930544746751 "NRAS MUT" "Sunitinib_IC_50" 0.961944050547353 0.994012653885573 -0.0254664490043296 0.54300462013118 0.940051886434805 0.250079588930125 0.483090070067376 0.931761829532683 0.367549776366136 "PTEN MUT" "Gemcitabine_IC_50" 0.923882469817389 0.98643792569589 -0.04548370870397 0.543009365770809 0.940051886434805 0.197358427664918 0.539628471775698 0.944569766818715 -0.296060068354456 "MLH1 MUT" "PF.562271_IC_50" 0.650147469695795 0.898913406720956 -0.203036247368422 0.543403888321536 0.940121979573454 -0.224581149557941 0.673106573150203 0.960256725054738 -0.186656854078963 "PIK3CA MUT" "AZD.2281_IC_50" 0.344167937642411 0.780249349533262 0.216756988879188 0.543409482568091 0.940121979573454 -0.106585435665692 0.594168062695559 0.949294892873838 -0.116888978116722 "TET2 MUT" "Thapsigargin_IC_50" 0.938881985685638 0.989111615050314 0.127720509872241 0.543447334006202 0.940121979573454 0.782138168449059 0.858868388471571 0.985224768537332 -0.352699331051587 "HRAS MUT" "RO.3306_IC_50" 0.308714755836642 0.75674113273833 -0.672049563850693 0.54347328489248 0.940121979573454 -0.384042983153517 0.508748522211036 0.938147991955214 -0.435071748389675 "FBXW7 MUT" "CHIR.99021_IC_50" 0.698751600936466 0.914968665673257 -0.120679524350647 0.543844094614255 0.940454625430415 -0.17990421135184 0.393341042692223 0.915926348152589 -0.266997296749411 "CDKN2A MUT" "AS601245_IC_50" 0.0372702184522872 0.351296460573821 -0.315072744595753 0.54387737374289 0.940454625430415 0.076938978775142 0.675183278867617 0.960256725054738 0.0718548904618185 "CDKN2a(p14) MUT" "AUY922_IC_50" 0.0228159394521225 0.276060433616212 -0.373312053910431 0.543986670343638 0.94046050599997 0.070233405730762 0.456281695875048 0.925809648901546 0.130513626793847 "FLCN MUT" "JW.7.52.1_IC_50" 0.761291955533536 0.93574319967042 0.474193095238098 0.5442543094128 0.940540099718321 -0.572321609205844 0.552321969610274 0.947310044825964 -1.66171025609704 "MYCN MUT" "JNJ.26854165_IC_50" 0.908951364040668 0.981529929795606 0.0331674074074079 0.544536320832897 0.940540099718321 0.173133805435013 0.724969054391367 0.965402608571648 0.121470307470776 "CCND1 MUT" "Pazopanib_IC_50" 0.250759913035941 0.717470497840808 0.426329779865318 0.544646834684399 0.940540099718321 0.192795821123277 0.37140981093621 0.913948248824328 0.325036946513965 "KDM6A MUT" "Vinorelbine_IC_50" 0.853195577983139 0.96439225252237 -0.0832778673287508 0.544794319085127 0.940540099718321 0.201252399188998 0.924027030101083 0.993978204254811 0.0446645806862416 "CTNNB1 MUT" "Lapatinib_IC_50" 0.722886866948043 0.923735002210874 -0.260537540792539 0.544949578815394 0.940540099718321 0.382053300173056 0.60519107591127 0.949657634568742 -0.370958318222356 "SMO MUT" "Cisplatin_IC_50" 0.317468455403662 0.761258739353268 1.17381294686907 0.54509324060138 0.940540099718321 0.612415975367574 0.489093968116592 0.933639405738697 0.774999700879571 "ALK MUT" "AZD6482_IC_50" 0.428770213984584 0.820918238409269 1.10183578103448 0.545105036050156 0.940540099718321 0.711669547932147 0.797133732399896 0.976360691959787 -0.492631609632906 "STK11 MUT" "Sorafenib_IC_50" 0.303719433404879 0.753234372540836 0.857509934931501 0.545221049027016 0.940540099718321 0.481385094181129 0.122650427050136 0.810576117427226 1.50925010234209 "FGFR2 MUT" "AZD7762_IC_50" 0.282547051531693 0.739072441127871 1.36000595428573 0.54539781812684 0.940540099718321 0.603237580852505 0.149338240052581 0.831473272394224 2.34199051908501 "STK11 MUT" "MS.275_IC_50" 0.625059696068982 0.890724841246629 0.483450300000002 0.545451774181557 0.940540099718321 0.497561298373114 0.760782659811749 0.969901216545994 0.356674513695727 "KIT MUT" "Bexarotene_IC_50" 0.787823918992053 0.946449577332088 -0.194164372377624 0.545456391976956 0.940540099718321 0.389681021102084 0.563537643566512 0.949294892873838 0.398794759059492 "IDH1 MUT" "ABT.888_IC_50" 0.434754041402531 0.823150425912549 0.584874620952392 0.545514691104419 0.940540099718321 0.379784465726863 0.536330766762849 0.943443271455699 0.436023788688404 "CDK4 MUT" "PD.0332991_IC_50" 0.431306475403567 0.820918238409269 0.52171639958159 0.545723629235161 0.940540099718321 -0.320570482999254 0.415612454030682 0.92211126027385 0.533352475618675 "RB1 MUT" "GW843682X_IC_50" 0.217102639633667 0.689960327486037 -0.49572511298297 0.545766433443491 0.940540099718321 -0.129229399753375 0.0177674996803305 0.513211661128791 -1.15207602787811 "MDM2 MUT" "Rapamycin_IC_50" 0.620082459412467 0.887671478437871 -0.674325427118643 0.545923300154177 0.940540099718321 -0.705072736339994 0.943357085830976 0.995314665488626 -0.0981045070720255 "GNAS MUT" "PD.0325901_IC_50" 0.700690438809575 0.915410639012359 -0.307746246492984 0.546134428765448 0.940540099718321 -0.453671944740421 0.531982457667381 0.94320946427311 -0.437128123050795 "APC MUT" "WZ.1.84_IC_50" 0.853111785154482 0.96439225252237 0.0953212185007961 0.546442335147983 0.940540099718321 0.267052223435159 0.183360160313992 0.851001889249827 0.770213368340148 "PTEN MUT" "CGP.60474_IC_50" 0.395294287606121 0.8037107527999 -0.249172584677419 0.546491285460273 0.940540099718321 -0.133969238485604 0.798824960095246 0.976360691959787 -0.0786372794747936 "JAK2 MUT" "Elesclomol_IC_50" 0.340970546393312 0.778598466389594 0.788875553639846 0.546504964466587 0.940540099718321 0.415446238659009 0.209880820477975 0.854552215275616 1.06798628167827 "PDGFRA MUT" "CHIR.99021_IC_50" 0.238906416767781 0.710855542080976 -0.75850778162911 0.546553292372211 0.940540099718321 -0.367484541280305 0.780081766669686 0.972337708041191 -0.176359049722354 "EP300 MUT" "GSK.650394_IC_50" 0.945731903480446 0.990164814713378 -0.0820004448315911 0.546651976877379 0.940540099718321 0.470163149623546 0.916341936508969 0.992403322408462 -0.125296929137249 "TET2 MUT" "GSK269962A_IC_50" 0.702853017440863 0.915500829364901 0.511695374149665 0.546739508419657 0.940540099718321 0.763053707211967 0.907009207907026 0.989089977335743 0.190204208133798 "IDH1 MUT" "NVP.BEZ235_IC_50" 0.640548028322835 0.895951701992251 -0.51046651491053 0.54676254650497 0.940540099718321 0.472793698774593 0.983052270032057 0.998011368051263 0.0221949900062627 "EWS_FLI1 MUT" "Salubrinal_IC_50" 0.744389474222654 0.929937110785116 0.172317413572341 0.546890600078932 0.940540099718321 -0.285613848212337 0.847039015072393 0.98378870157398 0.116517670314289 "CDK4 MUT" "CEP.701_IC_50" 0.362322872602635 0.787270200866664 0.536820994219655 0.546944287632729 0.940540099718321 -0.260714153634354 0.534944510321104 0.943443271455699 0.347715368926985 "CCND2 MUT" "IPA.3_IC_50" 0.575845168087415 0.872895290383193 0.668406015098715 0.547008851478925 0.940540099718321 0.600558606800069 0.835309397556888 0.981626636221501 0.282044103605744 "MAP2K4 MUT" "Nutlin.3a_IC_50" 0.567594839384392 0.872389778906173 0.311497269588316 0.54713463119716 0.940540099718321 0.300580245834281 0.617379355664584 0.950247055931602 0.291802566747265 "RUNX1 MUT" "CEP.701_IC_50" 0.946222948576536 0.990383736748169 -0.0721144841571603 0.547206462335248 0.940540099718321 0.470478759301117 0.813327945547811 0.977383317127464 -0.227144334509976 "BRCA2 MUT" "Nutlin.3a_IC_50" 0.279354798572808 0.737882141891724 1.01262195294118 0.547218393538549 0.940540099718321 0.518509952675287 0.703756356833082 0.962139809888331 0.346095022102702 "NRAS MUT" "CMK_IC_50" 0.350760182105933 0.784966682190403 -0.360551005367967 0.547244498241831 0.940540099718321 -0.218283773924972 0.393705000614107 0.915926348152589 -0.379192476184799 "PTEN MUT" "AZD7762_IC_50" 0.569594188866501 0.872389778906173 -0.126706592861357 0.547315756710312 0.940540099718321 0.107395717610477 0.776017467118965 0.972337708041191 -0.0627024609215452 "VHL MUT" "Bleomycin_IC_50" 0.869781587142888 0.969505966359972 0.192505492091389 0.547512396449238 0.940695993976723 0.579751018731854 0.620425108928858 0.950496524771391 0.607285153615005 "BRCA2 MUT" "AP.24534_IC_50" 0.686076063879375 0.911730003936733 0.459070173611116 0.547839764848265 0.940793525643629 -0.618094536089075 0.72303551509322 0.965402608571648 -0.382190879292859 "EP300 MUT" "FTI.277_IC_50" 0.34272222568659 0.779440739135111 -0.604950905008621 0.547869398400627 0.940793525643629 -0.35055166072071 0.625607665692497 0.951047873847153 -0.293791688182495 "RUNX1 MUT" "Axitinib_IC_50" 0.607892964334368 0.884017916530788 0.528243318124205 0.547894710713775 0.940793525643629 0.520712362834924 0.843350578407676 0.983031552042661 0.177295082251374 "MSH6 MUT" "Bexarotene_IC_50" 0.659691660809061 0.902400992643984 0.251791707381372 0.548164890900796 0.940793525643629 0.305529562852852 0.654511976600298 0.958313128388245 0.242916347077721 "CDKN2A MUT" "JNK.Inhibitor.VIII_IC_50" 0.221674563052552 0.694179053057023 -0.122003439340743 0.548165477420641 0.940793525643629 -0.0595260251969052 0.536687023813918 0.943443271455699 -0.0708910377016747 "CDK6 MUT" "AICAR_IC_50" 0.364088466149812 0.787306955898826 0.523202418300654 0.548204762437313 0.940793525643629 0.309310668633148 0.530234517058346 0.94320946427311 0.346995333603193 "FGFR2 MUT" "Gemcitabine_IC_50" 0.000743385043061146 0.036882695907408 6.82517911518332 0.548335565894848 0.940836197973752 0.82815501228793 0.0119279423045989 0.459749370120074 5.50293544994951 "NRAS MUT" "Gemcitabine_IC_50" 0.25061129054224 0.717470497840808 -0.745698015309297 0.548523462585894 0.940976795678062 0.270165576592421 0.465796104552931 0.929276781658587 0.506983891418043 "BCR_ABL MUT" "Midostaurin_IC_50" 0.522446848207206 0.853303159804623 0.599492519031136 0.548757784486397 0.940994097176677 -0.447061611309001 0.473167434696447 0.929276781658587 0.623016600269775 "KRAS MUT" "CEP.701_IC_50" 0.00945915834693199 0.171369896162435 0.562845583888914 0.548787748589787 0.940994097176677 0.10126609660734 0.353079455897868 0.911252930312559 0.212830671049591 "MSH6 MUT" "GW.441756_IC_50" 0.488091984205443 0.841371294978366 0.320825409688013 0.548851415761197 0.940994097176677 0.270805247018364 0.493880803263982 0.933639405738697 0.312255085996367 "CDKN2A MUT" "Tipifarnib_IC_50" 0.00915076725920271 0.168256654304305 -0.489478690712793 0.549195427813667 0.941122364883762 -0.0788264970849624 0.508887205534974 0.938147991955214 -0.140115056246066 "MAP2K4 MUT" "SB.216763_IC_50" 0.963586092582566 0.994159243759316 0.02121704950495 0.549473829984488 0.941122364883762 -0.268763490267943 0.418783280274019 0.922428741067589 -0.385774807825895 "FBXW7 MUT" "Docetaxel_IC_50" 0.414374652653497 0.813632830027793 0.314555008660656 0.549540956230091 0.941122364883762 -0.174974406539704 0.658290315149441 0.958313128388245 -0.174297860354992 "APC MUT" "Axitinib_IC_50" 0.0181268412810942 0.247069557579196 0.77584413861899 0.549616418322397 0.941122364883762 -0.174365974649564 0.897682065356825 0.988507677921136 0.0456919518035047 "BCR_ABL MUT" "WZ.1.84_IC_50" 0.464942300680482 0.829813619843923 0.616081575342474 0.549631649694869 0.941122364883762 0.4359893104639 0.492177989431578 0.933639405738697 0.560215646583488 "SETD2 MUT" "GDC0941_IC_50" 0.130635132654134 0.59349449267004 -1.94304028952776 0.549658949822256 0.941122364883762 -0.624262678879456 0.177129450655928 0.848722027112292 -1.72380301999863 "ALK MUT" "CMK_IC_50" 0.743554572933236 0.929570057037101 -0.281264506849315 0.549693277436413 0.941122364883762 -0.470485366538284 0.466237057387513 0.929276781658587 -0.749534093357947 "CDKN2C MUT" "LFM.A13_IC_50" 0.377176648996352 0.795261485512158 0.311467266313932 0.549875193600146 0.941122364883762 0.199318781066737 0.241173712885183 0.875707386589409 0.490980871137709 "MLLT3 MUT" "QS11_IC_50" 0.331180755923456 0.772603259108552 -0.423473738266534 0.549879962997617 0.941122364883762 -0.190538483481267 0.632601550103582 0.952523560833852 -0.212483476552822 "CCND1 MUT" "S.Trityl.L.cysteine_IC_50" 0.749034592485417 0.932323030730707 -0.196729559859154 0.550133183509097 0.941151884889811 -0.204826736686834 0.65134464827278 0.958313128388245 -0.328732140471827 "NF2 MUT" "A.443654_IC_50" 0.573862925895973 0.872620551543038 -0.36681739160839 0.550214228762017 0.941151884889811 0.260797576687678 0.876150005392148 0.987838063957761 0.113791887126303 "MAP2K4 MUT" "Pazopanib_IC_50" 0.383665022436772 0.798569876743396 -0.460330712084009 0.550215131893694 0.941151884889811 -0.268550872163518 0.0739958674313176 0.741621865836141 -0.946840342518183 "KDM6A MUT" "Lenalidomide_IC_50" 0.062604746616464 0.450196562510783 -0.500966581384011 0.550389692419942 0.941182723266156 -0.142352769782772 0.319039676184538 0.900918773778407 -0.266210163673009 "FGFR2 MUT" "Sunitinib_IC_50" 0.460625022371412 0.828966839128293 1.00890761205915 0.550539697369006 0.941182723266156 -0.61553647616909 0.269628106905773 0.878819138279722 -1.60864464944434 "VHL MUT" "RDEA119_IC_50" 0.911402531797879 0.982267477694927 0.0927552314629216 0.550551091922946 0.941182723266156 0.452747189499447 0.611962932585589 0.949930222127033 0.392374875186685 "BRCA1 MUT" "Camptothecin_IC_50" 0.146474831662716 0.619919550890177 1.63607703904765 0.550949346643973 0.941309821607171 0.42594374612547 0.182859932851131 0.851001889249827 1.31957277715948 "KDM5C MUT" "GNF.2_IC_50" 0.518425474328287 0.852460032866047 0.407444613013699 0.551319056779868 0.941309821607171 0.360895013112791 0.467159143350263 0.929276781658587 0.464593099367798 "FLCN MUT" "Vorinostat_IC_50" 0.663269415934209 0.903526384925934 0.319112055226825 0.551411844510252 0.941309821607171 0.332972641643173 0.770351463686936 0.969901216545994 -0.335764606916057 "IDH1 MUT" "SL.0101.1_IC_50" 0.828092196695632 0.958015830101332 -0.187223416506716 0.551542854627625 0.941309821607171 -0.445779949335221 0.770295424696902 0.969901216545994 -0.243340496966422 "SMARCB1 MUT" "Embelin_IC_50" 0.445646204436803 0.825858023699112 -0.773245234782615 0.55180882313772 0.941309821607171 -0.48034911699427 0.46589021299194 0.929276781658587 -0.740446236571845 "BCR_ABL MUT" "CEP.701_IC_50" 0.179768626673722 0.658614416960816 -1.24219664190478 0.551818039937805 0.941309821607171 0.417915582237168 0.658528867937371 0.958313128388245 0.382584343042614 "FGFR2 MUT" "TW.37_IC_50" 0.146261780739292 0.619919550890177 1.38773586995513 0.55182271397698 0.941309821607171 0.523339358652057 0.0379246234140844 0.645472009508728 2.67616401547727 "SOCS1 MUT" "MK.2206_IC_50" 0.215072275692647 0.688556914357028 -1.56714801649482 0.551871438585829 0.941309821607171 -0.602075353348103 0.480707780438378 0.930304161706959 -0.868228520284565 "FAM123B MUT" "Axitinib_IC_50" 0.638610934468494 0.895624997957207 0.419146122857148 0.551897434313877 0.941309821607171 -0.448823239552536 0.959617359232543 0.99641548698706 -0.0403068938632451 "ALK MUT" "CI.1040_IC_50" 0.33207631645748 0.773045810343088 -1.2282293912214 0.551937452733136 0.941309821607171 -0.675771875757516 0.0634408254561411 0.70501719149803 -2.0818538309299 "BRCA1 MUT" "NVP.TAE684_IC_50" 0.977038472973673 0.996276778834563 -0.0501328389261752 0.552151138119599 0.941309821607171 0.848293045959843 0.879139449593974 0.988115784617527 -0.269154112376433 "PTEN MUT" "Nilotinib_IC_50" 0.878007157517706 0.971802715567801 -0.0313469331864901 0.5523030142747 0.941309821607171 0.101256300796502 0.802772470459611 0.976365695720597 -0.0498463668314773 "FBXW7 MUT" "Thapsigargin_IC_50" 0.860072743490284 0.966384100200122 -0.110272437182636 0.552394344161631 0.941309821607171 0.284236731817206 0.892162244347908 0.988301482344111 -0.0857281870991969 "MYC MUT" "OSI.906_IC_50" 0.607120948323097 0.883763504680778 -0.166120339169063 0.552439487470393 0.941309821607171 -0.183188899793124 0.63621916913262 0.953101495776253 -0.162283579133551 "CCND3 MUT" "Methotrexate_IC_50" 0.843994544350591 0.960498931426639 0.308896122244484 0.552506587476435 0.941309821607171 -0.709349512815938 0.635510251628194 0.953101495776253 -0.586401768091285 "RB1 MUT" "WO2009093972_IC_50" 0.878791533467516 0.971802715567801 -0.0404002565874143 0.552512986957801 0.941309821607171 0.144225384586925 0.18917721733935 0.851001889249827 0.367733999284488 "FGFR3 MUT" "PF.02341066_IC_50" 0.818163500405715 0.955165737441734 -0.265296842281878 0.552562753866866 0.941309821607171 0.630196610305208 0.760919428589818 0.969901216545994 -0.345102280477744 "ERBB2 MUT" "CHIR.99021_IC_50" 0.937988310214857 0.98883650048509 0.0274770858927642 0.552566404223223 0.941309821607171 -0.203705529939726 0.428792732956023 0.922428741067589 -0.285947046843326 "CDKN2a(p14) MUT" "X681640_IC_50" 0.192758788840832 0.668215486666746 -0.196158646678171 0.552667890801222 0.941309821607171 -0.0796302453922538 0.414661978867957 0.92211126027385 -0.128076442605405 "KDM6A MUT" "AG.014699_IC_50" 0.958211684290273 0.993340772343095 0.0212079333333332 0.552745267388965 0.941309821607171 0.211727237435757 0.854124532684432 0.984631915507353 -0.069111964042103 "CDK6 MUT" "Pazopanib_IC_50" 0.306802898665456 0.755024525457845 0.685263669595784 0.553245397800596 0.941563845593877 0.338369209828789 0.639393427033565 0.954756033698446 0.306969324029354 "GNAS MUT" "Bortezomib_IC_50" 0.923158076763195 0.98643792569589 -0.109334571917808 0.55334994216166 0.941563845593877 0.545647641651504 0.876093836657891 0.987838063957761 -0.172850453552088 "CCND3 MUT" "Midostaurin_IC_50" 0.433377375780524 0.822749994507661 -0.734259159169569 0.553370588366066 0.941563845593877 -0.429155060036642 0.801310608117625 0.976360691959787 -0.214645059135528 "CDKN2a(p14) MUT" "TW.37_IC_50" 0.462549465788707 0.82931728663973 -0.0955934821291355 0.553463789061064 0.941563845593877 0.0720351821740127 0.745240099940505 0.968321481722257 -0.0450679885495199 "GNAS MUT" "CGP.60474_IC_50" 0.347014824087706 0.782020929432191 -1.01427490784982 0.553670479235798 0.941563845593877 -0.476532299536836 0.741285882688816 0.96672489654949 -0.349062065714304 "FBXW7 MUT" "Mitomycin.C_IC_50" 0.197696333667714 0.673988921037607 -0.620082329074523 0.553715527215421 0.941563845593877 -0.225109412003493 0.975214222461273 0.99742775226181 -0.0151372609510597 "FLCN MUT" "Roscovitine_IC_50" 0.354645335533015 0.785252181551816 0.897767243367938 0.553739774481756 0.941563845593877 0.506111784984349 0.54431333352069 0.946853280734584 -1.03804664797498 "RB1 MUT" "AZD8055_IC_50" 0.575293657076737 0.872620551543038 -0.116410691758241 0.55374259267389 0.941563845593877 -0.0984201851259615 0.412767117091723 0.921714070263062 -0.18296899020634 "MSH6 MUT" "RDEA119_IC_50" 0.285158322332369 0.740302864659114 -1.0261648243513 0.554010643397228 0.941664176586042 -0.514065842120334 0.0525995528525021 0.693081051755298 -1.57896939713505 "CDH1 MUT" "NVP.TAE684_IC_50" 0.252451477979361 0.717470497840808 1.26571157288135 0.554013660923552 0.941664176586042 0.548943486177441 0.140842435897013 0.831473272394224 1.66998677367713 "CCND3 MUT" "Mitomycin.C_IC_50" 0.623400250754411 0.889813183373501 -0.545906394415371 0.554356313079387 0.941842142822234 -0.514664243745523 0.644649811049346 0.956580613522012 -0.498870616674053 "KIT MUT" "Epothilone.B_IC_50" 0.215336645780799 0.688608753079032 -1.29818786363637 0.554453183805109 0.941842142822234 -0.355216966533002 0.250872032447023 0.875707386589409 -1.17607004088371 "EP300 MUT" "AZD7762_IC_50" 0.666098469434234 0.904922207808508 -0.446525583333346 0.554601979674308 0.941842142822234 -0.480079186867912 0.473062490738456 0.929276781658587 -0.671765724134621 "FLCN MUT" "Tipifarnib_IC_50" 0.187063161541261 0.662667705483822 1.3256327027972 0.554634668660441 0.941842142822234 -0.394702074894434 0.676008385087787 0.960256725054738 0.531511245879492 "FBXW7 MUT" "VX.702_IC_50" 0.057299933486957 0.430077283009252 -0.606397132855035 0.55484358334355 0.941842142822234 -0.154624281904198 0.392881540605809 0.915926348152589 -0.26917247051844 "MAP2K4 MUT" "JNK.Inhibitor.VIII_IC_50" 0.343233705854883 0.779805203811004 0.316085660194172 0.554858317801745 0.941842142822234 0.187871597700938 0.97481215574165 0.99742775226181 0.0117456872079272 "TET2 MUT" "AP.24534_IC_50" 0.70211839222945 0.915500829364901 -0.612740967184785 0.555213209137981 0.941842142822234 0.860721975514674 0.455826697615825 0.925809648901546 1.37654841572273 "MS-HL MUT" "Lenalidomide_IC_50" 0.978943941925697 0.996276778834563 -0.00376087778458883 0.555282306312901 0.941842142822234 0.0739419972388776 0.227314016082101 0.867648638924452 0.18016909807871 "BRAF MUT" "Pazopanib_IC_50" 0.721237972577151 0.922822998769296 0.0953048594566345 0.555294796042808 0.941842142822234 0.147259572939402 0.177791281692415 0.848722027112292 0.39305079433613 "EZH2 MUT" "Elesclomol_IC_50" 0.44425761003464 0.825606373270691 0.748570078244283 0.555561670900423 0.941842142822234 0.476783804089249 0.67179060015987 0.960256725054738 0.390700643129081 "BRCA1 MUT" "MG.132_IC_50" 0.767404318480829 0.938102925317033 0.496129763513514 0.555670921340032 0.941842142822234 0.872243063025425 0.453020142737642 0.925809648901546 1.18491835841462 "EWS_FLI1 MUT" "GDC0941_IC_50" 0.202135327589706 0.674012093366938 -0.627678644210527 0.555925013017406 0.941842142822234 0.251903974293743 0.877311859590565 0.987838063957761 -0.0883601602827157 "MDM2 MUT" "WO2009093972_IC_50" 0.756675816156939 0.934762260113025 0.152800507042253 0.555960542125445 0.941842142822234 -0.260140425958473 0.741583938023382 0.96672489654949 0.159969116358819 "FBXW7 MUT" "AKT.inhibitor.VIII_IC_50" 0.706264118477823 0.916471600847684 -0.13116671931818 0.555974235470273 0.941842142822234 -0.1763416419157 0.825399282807005 0.980029315589217 -0.0779886538740256 "SMARCA4 MUT" "ABT.888_IC_50" 0.733990676786412 0.928593402067957 0.114701481624759 0.556313010433632 0.941842142822234 -0.166631165048649 0.636649075254261 0.953101495776253 -0.170174535365924 "PIK3R1 MUT" "AUY922_IC_50" 0.0575777313990368 0.43115331581353 1.27816903646749 0.556416822434857 0.941842142822234 0.266371051305892 0.131424114911241 0.824721122422311 0.966579375054946 "EP300 MUT" "BI.2536_IC_50" 0.121903483245609 0.580982694522287 -2.48413704406778 0.556464592724448 0.941842142822234 -0.561034601831441 0.150349566393002 0.831473272394224 -2.39473474584071 "MYCN MUT" "Elesclomol_IC_50" 0.568801370895135 0.872389778906173 -0.289958701651186 0.55652602829033 0.941842142822234 -0.254279050913156 0.163828649644425 0.839927262232576 -0.78437349323914 "MYCL1 MUT" "PLX4720_IC_50" 0.361568025486403 0.787174158907433 0.656007988416984 0.556706984027737 0.941842142822234 0.374384903672303 0.47709304342088 0.930206773177301 0.509976931590075 "CCND3 MUT" "VX.702_IC_50" 0.821151875792573 0.956293356389236 0.239998263358778 0.556716187757893 0.941842142822234 -0.508952296947985 0.880750987674903 0.988301482344111 -0.147379051997425 "APC MUT" "SB.216763_IC_50" 0.0923887847813878 0.520483603614995 0.467521888037466 0.556754270509243 0.941842142822234 0.165886095312078 0.286405859478864 0.888460548829126 0.343220689852628 "EP300 MUT" "NSC.87877_IC_50" 0.720839441988264 0.922822998769296 0.231539378238337 0.556841124429362 0.941842142822234 0.375852311048514 0.658712552448093 0.958313128388245 0.288874990519226 "SMAD4 MUT" "Docetaxel_IC_50" 0.588699717916124 0.876506729771444 -0.193142716850726 0.556885818266566 0.941842142822234 0.161043562153832 0.316948955087705 0.900918773778407 -0.365795736943936 "SMAD4 MUT" "NSC.87877_IC_50" 0.966102163324065 0.994434372972651 0.00906298559581005 0.55689406837272 0.941842142822234 0.126887646129519 0.70512897850153 0.962630898212352 0.087959175776707 "APC MUT" "Parthenolide_IC_50" 0.883528858573009 0.973927829424842 0.0717560858585866 0.557065454812029 0.941842142822234 0.27617359317791 0.898460063070237 0.988526046030225 -0.0769686771230933 "BRAF MUT" "Doxorubicin_IC_50" 0.607883444617027 0.884017916530788 -0.14182865670498 0.557114127498506 0.941842142822234 0.111628615942145 0.172322612205941 0.842832361237713 -0.429356005845113 "KDM5C MUT" "Epothilone.B_IC_50" 0.999107076339981 0.999548905963057 0.00131068411867383 0.557392236642491 0.941842142822234 0.391614619216788 0.93156098651509 0.994235539701634 0.0977856435479901 "MYCL1 MUT" "PD.0325901_IC_50" 0.237352647449625 0.709759716521808 1.00970903742859 0.557421159510033 0.941842142822234 0.470026041655534 0.799193102988784 0.976360691959787 0.209473803245355 "RUNX1 MUT" "SB590885_IC_50" 0.618654498002366 0.887317602835758 0.524577454361045 0.557514659689012 0.941842142822234 0.515405616926867 0.8159006856498 0.977383317127464 0.212805184245217 "NF2 MUT" "VX.680_IC_50" 0.2331634422495 0.706490798573119 -1.00722543706293 0.557535772044136 0.941842142822234 -0.33220221844434 0.35305942961374 0.911252930312559 -0.887997921632445 "SMARCB1 MUT" "FH535_IC_50" 0.380355391484049 0.797435371050481 -0.987579726956531 0.557535909848146 0.941842142822234 -0.56418787710442 0.636663927179846 0.953101495776253 -0.515612119218308 "ERBB2 MUT" "NVP.BEZ235_IC_50" 0.221553305347358 0.694044058126944 0.465069772299903 0.557614061761744 0.941842142822234 -0.166264463885944 0.804114905577053 0.976660896667097 -0.0957146192910933 "FAM123B MUT" "Vorinostat_IC_50" 0.39031753585748 0.801837403580487 0.629430792899414 0.557618059560782 0.941842142822234 -0.327985835299052 0.625272018361099 0.950863149839883 0.328562063126077 "EGFR MUT" "BMS.509744_IC_50" 0.274799926259994 0.73402283606276 0.607945156794428 0.557808797849682 0.941927789587651 0.23982947626538 0.194027556781548 0.851001889249827 0.717505306759862 "SMAD4 MUT" "AZD8055_IC_50" 0.125951589788431 0.586978030371663 0.445079252780084 0.557880888777282 0.941927789587651 0.134958700680705 0.256017963344854 0.875707386589409 0.339779731826082 "RB1 MUT" "PF.562271_IC_50" 0.868477376232399 0.968770736448595 0.0325882614628371 0.558028522183659 0.941997967214042 -0.0963680228446024 0.838791863992057 0.981704379975756 -0.0448443645888894 "IDH1 MUT" "JNK.Inhibitor.VIII_IC_50" 0.633186611158157 0.89399270048764 -0.386252590476197 0.558360006808956 0.942202789866654 -0.450534051715675 0.676873875937122 0.960274263929326 -0.341729996216209 "MLL_AFF1 MUT" "PD.173074_IC_50" 0.202936746869103 0.674758985003557 -1.29847238281248 0.558464841703724 0.942202789866654 0.519012573051846 0.95925831595234 0.99641548698706 -0.0485518363321875 "FBXW7 MUT" "NVP.BEZ235_IC_50" 0.954264691960345 0.992679871625456 -0.0192940338791645 0.558468132626739 0.942202789866654 -0.142778697604266 0.341489638251047 0.907180409180092 -0.325087659341572 "NOTCH1 MUT" "BAY.61.3606_IC_50" 0.0332669274809638 0.336031521689191 -1.02976384870767 0.558661469101712 0.942349953863686 0.202684198154485 0.83938455356752 0.98178039101519 0.101699853427067 "KDM5C MUT" "Sunitinib_IC_50" 0.926324538056785 0.98643792569589 -0.109742476027397 0.558865494488232 0.942424052252336 0.513540814757999 0.855905939809497 0.984631915507353 -0.187699767266597 "SMAD4 MUT" "ABT.888_IC_50" 0.836377792077392 0.959177578956524 0.0431411779259262 0.55904221925794 0.942424052252336 -0.105824231605571 0.948128454668116 0.995668765770473 -0.0135031301067134 "FBXW7 MUT" "BMS.509744_IC_50" 0.513470686656388 0.85130999259055 -0.364000278745647 0.559054009143425 0.942424052252336 0.246203966387773 0.749297234510958 0.968780465757047 0.180989582402638 "RUNX1 MUT" "Bosutinib_IC_50" 0.63835633484844 0.895624997957207 0.48903549173029 0.559159579119908 0.942424052252336 0.497425887504984 0.506968491890569 0.936562389753569 0.633765696424251 "FLT3 MUT" "Thapsigargin_IC_50" 0.702784806884843 0.915500829364901 -0.550879134380466 0.559235981913052 0.942424052252336 0.649946492364288 0.736631722707372 0.96672489654949 -0.475027658172268 "FGFR2 MUT" "WH.4.023_IC_50" 0.953109386829407 0.992561499112566 -0.1211773629124 0.559740517577151 0.942779323420636 -1.06782213165241 0.14829120987273 0.831473272394224 -3.38628915952179 "RUNX1 MUT" "Elesclomol_IC_50" 0.829225830728369 0.958015830101332 0.272022742078579 0.559830589846685 0.942779323420636 0.60861362007389 0.694723027828014 0.961100601384891 0.46382676177208 "MET MUT" "Dasatinib_IC_50" 0.522036629327485 0.853303159804623 1.77542581632654 0.560090056822542 0.942779323420636 1.32527337487892 0.0564238313749744 0.697813103075383 4.59287287726626 "ERBB2 MUT" "Doxorubicin_IC_50" 0.424382373506238 0.818622905975 0.383400194222689 0.560110464030825 0.942779323420636 -0.178994822049971 0.856099963054083 0.984631915507353 -0.0878805910866849 "SETD2 MUT" "Gemcitabine_IC_50" 0.284973034174721 0.740302864659114 3.06792323130438 0.560257769924663 0.942779323420636 -1.13159792495203 0.287287016365312 0.888563331668781 2.86176699990855 "CDH1 MUT" "LFM.A13_IC_50" 0.23949585144014 0.711120914958168 0.436795657276999 0.560392032275579 0.942779323420636 0.206408764322002 0.380699871092208 0.915134825237766 0.347118089940891 "CDK6 MUT" "MS.275_IC_50" 0.797940253809195 0.949524851900765 0.325893734018263 0.560454899569832 0.942779323420636 -0.611677177845382 0.404602317470198 0.917353377955789 1.34838667201929 "FGFR3 MUT" "A.443654_IC_50" 0.277579297580738 0.735493799937367 -1.560777707483 0.560523387566677 0.942779323420636 0.542408218121766 0.472464507433647 0.929276781658587 -1.0573003086467 "BRCA1 MUT" "Pazopanib_IC_50" 0.686865938034202 0.911748124009352 0.381076894415364 0.560632366004313 0.942779323420636 0.468840953402737 0.565993107603335 0.949294892873838 0.499191980161668 "STK11 MUT" "BMS.754807_IC_50" 0.38399634269073 0.798569876743396 0.417742041365284 0.560918826980641 0.942779323420636 0.2334343010079 0.475726128389611 0.929855889225741 0.357219277761971 "NF2 MUT" "LFM.A13_IC_50" 0.462342080738754 0.82931728663973 -0.180664174374788 0.560920810324798 0.942779323420636 -0.134932255291955 0.454296653838821 0.925809648901546 0.197424141591904 "FAM123B MUT" "Tipifarnib_IC_50" 0.958536631274865 0.993432616972253 0.0522784370629398 0.560921674665013 0.942779323420636 -0.388574573219132 0.783842904594865 0.974078058737889 0.275202034702937 "MSH2 MUT" "Bicalutamide_IC_50" 0.508987150408066 0.848726038823513 0.15576289724311 0.56093581258884 0.942779323420636 0.131519808057457 0.895859742247521 0.988301482344111 -0.0292146447044733 "TP53 MUT" "PAC.1_IC_50" 0.883512618134368 0.973927829424842 0.0222585325681304 0.561036008639438 0.942779323420636 -0.0771176815888138 0.569183343194053 0.949294892873838 -0.0900013483442568 "KDM5C MUT" "CCT007093_IC_50" 0.578302903104036 0.873750949722175 0.325765771812078 0.561039153730218 0.942779323420636 0.342104716394776 0.510786483043697 0.938693162701913 0.388606701904088 "HRAS MUT" "Mitomycin.C_IC_50" 0.86913053034118 0.969083269298182 0.163994145104893 0.561198751399625 0.942846706415182 -0.45366748537225 0.803981586128302 0.976660896667097 0.240358869585964 "KRAS MUT" "GDC0941_IC_50" 0.000272343115982267 0.0198775318300914 0.798811835330433 0.561333800672002 0.942846706415182 0.109694799178487 0.0225348185268281 0.557469981439444 0.59012285736705 "PTEN MUT" "CCT018159_IC_50" 0.401022534950396 0.806415132522709 -0.163820870279857 0.561470932323054 0.942846706415182 -0.10831792813739 0.188556561767247 0.851001889249827 -0.283011659326639 "VHL MUT" "MG.132_IC_50" 0.923782137424705 0.98643792569589 -0.113868401360545 0.56150391062154 0.942846706415182 0.617429000106703 0.282439159496796 0.887908734687095 1.24542834600606 "PIK3R1 MUT" "Docetaxel_IC_50" 0.498336506007293 0.845109283443017 0.435967671874997 0.561684136251458 0.942971042353346 -0.279983067763338 0.728985409872624 0.965407830614903 0.214204675144315 "STK11 MUT" "Roscovitine_IC_50" 0.810864934282734 0.952889749533063 0.18054174216028 0.562021692303288 0.943210846739208 0.387131633318133 0.894736339577808 0.988301482344111 -0.113763892125879 "PIK3CA MUT" "BIBW2992_IC_50" 0.501221084536082 0.846334637471348 0.186245683760685 0.562039387562649 0.943210846739208 0.156389002765248 0.00262587400129837 0.272034735859731 0.842677371657309 "CDKN2C MUT" "MS.275_IC_50" 0.447853142269013 0.826231147407263 -0.686423257208766 0.562244028078578 0.943333538088328 -0.436087372134444 0.583706790086809 0.949294892873838 -0.625679549945966 "FLCN MUT" "MG.132_IC_50" 0.634977516115873 0.89462773886888 0.651217581920904 0.562536383154095 0.943333538088328 0.700394282258764 0.948763069259591 0.995668765770473 0.144723734974505 "MYCL1 MUT" "PD.173074_IC_50" 0.753951302187581 0.933869109446012 -0.171827162581006 0.56253893135403 0.943333538088328 -0.270657663424463 0.342435314516966 0.907180409180092 -0.526452897154767 "NF1 MUT" "Sorafenib_IC_50" 0.3598783848222 0.786601117838604 0.463493340232204 0.562636868586461 0.943333538088328 0.28055395976415 0.562890934251786 0.949294892873838 0.341999525851818 "APC MUT" "Paclitaxel_IC_50" 0.821479790101731 0.956293356389236 -0.180561559440561 0.56264359320503 0.943333538088328 0.207757690009446 0.447105718197693 0.925809648901546 0.720012456525756 "FGFR3 MUT" "PD.173074_IC_50" 0.753145088163102 0.933869109446012 0.320968945312496 0.562957351396827 0.943370481555637 0.504307654753145 0.813330943027569 0.977383317127464 -0.220957950410867 "KIT MUT" "Camptothecin_IC_50" 0.544435391710069 0.862633715268747 -0.683479641904767 0.563056277773269 0.943370481555637 0.413354834247911 0.470762958561747 0.929276781658587 -0.723355539783994 "PIK3CA MUT" "Docetaxel_IC_50" 0.41173307443282 0.812480994891775 -0.222630289353957 0.563079227182091 0.943370481555637 -0.119085940802047 0.547304670226626 0.947060194029534 -0.172905654186987 "MS-HL MUT" "GNF.2_IC_50" 0.434094256305254 0.823150425912549 0.168445221291031 0.563090521644683 0.943370481555637 0.1193401024973 0.328067892492757 0.902810042912437 0.242229158979757 "CCND3 MUT" "Metformin_IC_50" 0.549607670293386 0.864873049004332 0.610366730038029 0.563284395492134 0.943517020215549 0.549396084559506 0.686701619676655 0.961100601384891 0.401453088620969 "MDM2 MUT" "WZ.1.84_IC_50" 0.999671220983242 0.999842122472917 0.000311408934707022 0.563490035758197 0.943517020215549 0.363340037018404 0.489580797516158 0.933639405738697 0.49647717482224 "SMAD4 MUT" "AG.014699_IC_50" 0.96775192230956 0.994434372972651 0.0117473683922722 0.563673811252887 0.943517020215549 -0.15236537772191 0.222808851208753 0.865601665610206 -0.347881057744577 "SMARCB1 MUT" "Doxorubicin_IC_50" 0.442984552711579 0.825539266593482 -1.05939614434783 0.563700512968757 0.943517020215549 -0.495781211567103 0.41128558130356 0.921714070263062 -1.0935293408759 "RB1 MUT" "WH.4.023_IC_50" 0.134477843306091 0.601893367640051 0.875035762294325 0.563791741501958 0.943517020215549 0.307692454336312 0.901527523336535 0.988746233284632 -0.0793380552801157 "CDK6 MUT" "RDEA119_IC_50" 0.718652666127712 0.92132587844031 -0.283407882195447 0.563815429150312 0.943517020215549 -0.409994713157442 0.471290928905834 0.929276781658587 0.483960085463059 "GNAS MUT" "AUY922_IC_50" 0.535845762732776 0.859928843301371 0.373913 0.564010867102923 0.94366626050133 -0.23414998837197 0.961854347252401 0.996625877572729 -0.0278155314097763 "MET MUT" "ZM.447439_IC_50" 0.0445429695451573 0.377107828913767 0.976689126875123 0.564143020485433 0.943709580887386 0.22375938230847 0.252179876251828 0.875707386589409 0.526045913341755 "TET2 MUT" "BI.2536_IC_50" 0.382522879308683 0.798569876743396 -1.14859414285715 0.564310190163697 0.943788491349873 -0.455204480904249 0.324519649922156 0.900918773778407 -1.63733492415081 "CTNNB1 MUT" "DMOG_IC_50" 0.976137111318202 0.996276778834563 0.0140057142857143 0.564460463020163 0.943788491349873 0.242276097405129 0.990472390919872 0.998681346929993 0.00592438417325043 "MLLT3 MUT" "Pyrimethamine_IC_50" 0.53975887143993 0.861547651912703 0.458460871080141 0.564676323066045 0.943788491349873 0.360813856002162 0.288996172305167 0.889281028047524 0.839436931976115 "FBXW7 MUT" "PD.0332991_IC_50" 0.253734010625156 0.718791626271773 -0.51333583019272 0.564725673383383 0.943788491349873 -0.207758493994082 0.945649322261065 0.995668765770473 -0.0306818148225977 "BRCA2 MUT" "Rapamycin_IC_50" 0.690132334242056 0.912742406612613 0.853189258389252 0.564753148953511 0.943788491349873 -1.06234718013112 0.388898179183673 0.915926348152589 1.89087868025744 "CTNNB1 MUT" "BMS.708163_IC_50" 0.555506201163074 0.867523275183957 -0.209337504566208 0.565084144515975 0.943788491349873 -0.206774783725676 0.270820215136508 0.879734431423575 -0.438032559329134 "RUNX1 MUT" "PD.173074_IC_50" 0.403005773756527 0.807551344312402 0.697340117416834 0.56510457489489 0.943788491349873 0.408577516052095 0.632100233863482 0.952523560833852 0.364205961644979 "CCND1 MUT" "JNJ.26854165_IC_50" 0.924016977850109 0.98643792569589 -0.0219546627779803 0.56520233074129 0.943788491349873 -0.124516830506393 0.169431552463397 0.84067330207935 -0.323131140234854 "HRAS MUT" "Cytarabine_IC_50" 0.113117625649475 0.563938179281427 -1.28906976226895 0.565229665190447 0.943788491349873 -0.355512173966123 0.211500076490534 0.855272470862467 -0.941239526685126 "CDKN2A MUT" "Shikonin_IC_50" 0.0967368259396452 0.530648394793075 -0.284309569883138 0.565325888863493 0.943788491349873 0.087133058015629 0.744682331274046 0.96773833538847 0.0624063271539643 "FBXW7 MUT" "Pazopanib_IC_50" 0.703213266314727 0.915500829364901 -0.156044829975429 0.565411239485955 0.943788491349873 -0.200919938142463 0.174533089750477 0.84578207413725 -0.527943772476037 "NF1 MUT" "ATRA_IC_50" 0.401709328485583 0.806415132522709 0.314965955086583 0.565758087193683 0.943788491349873 -0.170817372604855 0.473398192858056 0.929276781658587 0.250783252732023 "SETD2 MUT" "Bryostatin.1_IC_50" 0.987923211489698 0.997992312673585 0.0135166104347828 0.565882681570895 0.943788491349873 0.48629713871469 0.522295336757446 0.939919936320746 0.546232614528966 "SMO MUT" "Pazopanib_IC_50" 0.473639020376351 0.834460661638643 -0.956176690434787 0.565954174938466 0.943788491349873 -0.648743414929051 0.279571075946863 0.88601917827756 -1.31165762619639 "RB1 MUT" "SL.0101.1_IC_50" 0.141370756528393 0.613643054119577 -0.252853013153873 0.566403881805174 0.943788491349873 -0.0869732679050782 0.0447704639124569 0.662759199838072 -0.367564626180001 "HRAS MUT" "CHIR.99021_IC_50" 0.748053008164102 0.932115582035752 0.206986845753897 0.566568545318996 0.943788491349873 0.351606130059909 0.180156459771019 0.848722027112292 0.833523878270864 "FAM123B MUT" "JNK.9L_IC_50" 0.214051229382369 0.688117861819268 0.765999821490461 0.567207001869824 0.943788491349873 0.275981461258422 0.227783645283143 0.867648638924452 0.747620548915397 "GNAS MUT" "SB590885_IC_50" 0.184225050743167 0.660385845878234 0.860673944672128 0.567224754004204 0.943788491349873 0.309502822191414 0.376224114608796 0.914419412871569 0.501121000820378 "KRAS MUT" "Etoposide_IC_50" 0.995014500538285 0.998977896287767 0.00182337629268287 0.567250336270182 0.943788491349873 -0.114598013325874 0.645560061247014 0.956971941901975 -0.145604545617325 "PIK3CA MUT" "Cisplatin_IC_50" 0.368083387924092 0.789246419666677 0.217878829866152 0.567284408133861 0.943788491349873 0.121602607258139 0.838456556666704 0.981704379975756 0.0520231920084809 "FGFR3 MUT" "Bryostatin.1_IC_50" 0.873645835228797 0.970705450102207 0.116049804297328 0.567339000221116 0.943788491349873 0.39323852241172 0.899487417105388 0.988704788932507 0.0878112039380112 "VHL MUT" "Shikonin_IC_50" 0.829323527650575 0.958015830101332 -0.15698853397212 0.56738671420909 0.943788491349873 0.352146945369472 0.944564031753286 0.995333788087439 -0.053544280490181 "CCND1 MUT" "A.770041_IC_50" 0.544527224280475 0.862633715268747 0.456521045614036 0.567467066827886 0.943788491349873 0.357086694896628 0.490723198316807 0.933639405738697 0.573209013479307 "CCND1 MUT" "Obatoclax.Mesylate_IC_50" 0.638897955209049 0.895624997957207 0.213016493602692 0.567514981814319 0.943788491349873 -0.192034400077916 0.703133443084902 0.962139809888331 0.177982388137927 "CCND3 MUT" "Doxorubicin_IC_50" 0.79471938545254 0.948646027682356 -0.254563801047126 0.567565953935284 0.943788491349873 -0.348752890589173 0.670322502473942 0.95927684711462 -0.396750989054735 "MET MUT" "Epothilone.B_IC_50" 0.343200242447961 0.779805203811004 -0.673288605525222 0.567702484193817 0.943788491349873 -0.231881827071997 0.480307123514802 0.930304161706959 -0.490206906132364 "FGFR2 MUT" "Nutlin.3a_IC_50" 0.58236519457779 0.876506729771444 0.726895011718743 0.568109528226522 0.943788491349873 0.696391589698713 0.807789832643764 0.977383317127464 -0.439015299445223 "CTNNB1 MUT" "Camptothecin_IC_50" 0.368321567972694 0.789246419666677 -0.567478299194985 0.568218646497248 0.943788491349873 -0.228181125098932 0.0621345434839995 0.702860976445846 -1.13242062057365 "KDR MUT" "Doxorubicin_IC_50" 0.355017190486138 0.785252181551816 -1.04363356504064 0.568392840472255 0.943788491349873 -0.401255373758989 0.339692965148975 0.907039453844874 -1.03613734082481 "VHL MUT" "Cisplatin_IC_50" 0.609978350135201 0.884443710620525 -0.301306529750472 0.568414133442348 0.943788491349873 -0.293831464528431 0.751697335599438 0.968780465757047 -0.194135806328527 "MSH6 MUT" "X17.AAG_IC_50" 0.549190284223591 0.864873049004332 -0.500154309065931 0.568439564761261 0.943788491349873 -0.418638869382894 0.203972864013246 0.853438950500765 -0.925768490025539 "CDKN2A MUT" "AZ628_IC_50" 0.000277446253981301 0.0198775318300914 -1.17846648740963 0.568446942823245 0.943788491349873 -0.147682814148859 0.409649093521768 0.921036354320715 -0.269684136872768 "ALK MUT" "WO2009093972_IC_50" 0.407259609330498 0.809352267869285 -0.90507079262673 0.568451898726837 0.943788491349873 -0.561374877168298 0.410655950450057 0.921714070263062 -0.899551595687144 "PIK3R1 MUT" "Cyclopamine_IC_50" 0.732388396608939 0.928176068595523 0.228003875432525 0.56848596531864 0.943788491349873 -0.347910528099478 0.622755409538616 0.950496524771391 0.325685058166649 "KRAS MUT" "Thapsigargin_IC_50" 0.0953882988430213 0.528144315476853 -0.571465073441728 0.568507411611072 0.943788491349873 -0.157666325320495 0.15811958499256 0.83854630828105 -0.537752939742376 "CDK6 MUT" "PD.0325901_IC_50" 0.48712761405069 0.840863415759626 0.5249551064257 0.568587503912336 0.943788491349873 0.404421130760218 0.0658483375571657 0.711992560878964 1.21251181959963 "MLLT3 MUT" "Vinorelbine_IC_50" 0.828551194464429 0.958015830101332 -0.0953058384740255 0.568742904733663 0.943788491349873 0.184056083566709 0.77257376493302 0.970470665681775 0.130274423310987 "SMARCA4 MUT" "Rapamycin_IC_50" 0.399135175954094 0.805918367644724 1.47510235353533 0.568868822725382 0.943788491349873 0.859422303543098 0.668341900606683 0.959230524020512 1.30452297476198 "PIK3R1 MUT" "A.770041_IC_50" 0.109618567004169 0.557499836095061 1.84130583219177 0.569050622327086 0.943788491349873 0.532909625915093 0.0879817883175804 0.755673367551674 1.84723821211699 "PDGFRA MUT" "BMS.754807_IC_50" 0.982743232727682 0.996723172778267 0.0223662290209789 0.569149576099236 0.943788491349873 0.491625630526324 0.834723583446134 0.981626636221501 0.215087150696541 "EWS_FLI1 MUT" "GDC.0449_IC_50" 0.235551323144279 0.708702464036204 -0.392439274421236 0.569197776328312 0.943788491349873 -0.180487852458832 0.972058623230911 0.99742775226181 -0.0133175477987536 "EGFR MUT" "LFM.A13_IC_50" 0.598317074288439 0.879232253518807 0.123973583424894 0.569218250188056 0.943788491349873 0.126937869173826 0.723730989370782 0.965402608571648 0.0870972149254306 "CDKN2a(p14) MUT" "CGP.082996_IC_50" 0.0147873917784675 0.221461764560827 -0.492572437500001 0.569409717473622 0.943788491349873 -0.104589062870272 0.240899833642848 0.875707386589409 -0.267602598400068 "GNAS MUT" "BMS.754807_IC_50" 0.30668112401222 0.755024525457845 0.750367652910052 0.569411423541253 0.943788491349873 0.348649593727774 0.389246851402006 0.915926348152589 0.624717527333323 "KDR MUT" "AZD.2281_IC_50" 0.69501058713402 0.913615900582776 0.339930581854043 0.569416383493633 0.943788491349873 0.372358421067502 0.647626754305432 0.957449344088104 0.352228661502982 "PDGFRA MUT" "KU.55933_IC_50" 0.556538182608657 0.86788684806804 0.331631825396826 0.56946456353699 0.943788491349873 0.285379633290993 0.529177060442758 0.943054040048671 0.355146184725378 "CDKN2a(p14) MUT" "BMS.754807_IC_50" 0.0156283831980973 0.227586688087166 -0.48183219543021 0.56949173944277 0.943788491349873 -0.0990979104869898 0.199674883983133 0.851001889249827 -0.280256729514404 "CDKN2a(p14) MUT" "AZ628_IC_50" 0.000602180707542386 0.0332380402971253 -1.14427670139035 0.569595402641907 0.943788491349873 -0.152938468731547 0.397096205960283 0.916480913435499 -0.280048893776271 "FLT3 MUT" "Tipifarnib_IC_50" 0.433777080142532 0.823150425912549 -0.878988087260053 0.569715521594285 0.943788491349873 0.429078522741965 0.782302019359081 0.973465634570267 -0.307497269269107 "MYC MUT" "JNK.Inhibitor.VIII_IC_50" 0.671430843172656 0.906916702390321 -0.079706570841888 0.569826984962989 0.943788491349873 -0.102458806253841 0.62789819335304 0.952146453272921 -0.0960165701289509 "SOCS1 MUT" "SL.0101.1_IC_50" 0.594621961645634 0.878675148315287 -0.458761804222643 0.570133465909715 0.943788491349873 0.426684485590806 0.886090380913741 0.988301482344111 -0.118552223846834 "MS-HL MUT" "QS11_IC_50" 0.155336954199657 0.630721638230745 -0.357221500142648 0.570163582740318 0.943788491349873 0.105851181622749 0.132196990989722 0.824786416167871 -0.411375063324788 "PIK3R1 MUT" "PD.0332991_IC_50" 0.196640116578242 0.672783946439227 0.906480676409178 0.57039745017425 0.943788491349873 0.317903223851127 0.389307859592776 0.915926348152589 0.56355595201663 "EZH2 MUT" "NVP.TAE684_IC_50" 0.264303948091487 0.726560302215652 1.37805367905407 0.570425040364436 0.943788491349873 -0.576536128853026 0.121888049671016 0.809590452621284 2.19378451504411 "BRCA2 MUT" "PF.02341066_IC_50" 0.954830060702422 0.992679871625456 -0.0653639563758382 0.570629828045262 0.943788491349873 -0.608841146083398 0.987273069288496 0.998124818853736 -0.0182776590966429 "BRCA1 MUT" "Vinorelbine_IC_50" 0.58275116977788 0.876506729771444 0.499564029462733 0.570701108818928 0.943788491349873 -0.378462171283738 0.469429008018605 0.929276781658587 0.648127000349606 "MLL_AFF1 MUT" "Axitinib_IC_50" 0.325322985188471 0.766643855599989 -1.23863364895635 0.570807419575326 0.943788491349873 0.613052126766366 0.825758289444219 0.980029315589217 0.24645819565591 "EP300 MUT" "Bryostatin.1_IC_50" 0.385135280311205 0.798746759187088 -0.633557634727055 0.570920186572364 0.943788491349873 -0.391452363643405 0.619672804524471 0.950496524771391 -0.344126578963461 "NF2 MUT" "BAY.61.3606_IC_50" 0.779577525327467 0.942683810925913 0.11892813626242 0.571098748454507 0.943788491349873 0.167763765549395 0.510173023308553 0.938422873866617 0.283272906468933 "FBXW7 MUT" "CMK_IC_50" 0.18885978994474 0.663737156509391 -0.758595998451409 0.571243998466374 0.943788491349873 -0.303258712908826 0.145504743365366 0.831473272394224 -0.883119128151537 "TSC1 MUT" "AKT.inhibitor.VIII_IC_50" 0.856307948446523 0.96514911547635 0.205390463793108 0.571397714930826 0.943788491349873 -0.551311872902304 0.676248506685352 0.960256725054738 0.461457180821108 "MAP2K4 MUT" "GSK269962A_IC_50" 0.505867876348463 0.847796212975596 0.773958754266211 0.571402970595576 0.943788491349873 0.619260545252023 0.854598435449609 0.984631915507353 0.24752075576731 "CTNNB1 MUT" "KU.55933_IC_50" 0.587416507157488 0.876506729771444 0.191315787841193 0.571462849812284 0.943788491349873 0.177618164855109 0.609299360282201 0.949930222127033 -0.193933363018741 "MYCL1 MUT" "AZD.2281_IC_50" 0.857943882599974 0.965651207814682 0.095512559760957 0.571483252760796 0.943788491349873 0.227531242631586 0.86775990879819 0.987342922214615 0.0856427454390427 "EWS_FLI1 MUT" "XMD8.85_IC_50" 0.778253564596513 0.942157839037845 0.157550218438808 0.57148796217237 0.943788491349873 0.290055998251 0.89268641268135 0.988301482344111 0.0853973923564866 "TSC1 MUT" "Thapsigargin_IC_50" 0.370418395753009 0.790219979025337 1.82507587130437 0.571576671751015 0.943788491349873 0.879391676171887 0.330760011378608 0.902810042912437 1.92014347982709 "SMARCA4 MUT" "FH535_IC_50" 0.661076551980831 0.902400992643984 -0.212179777224543 0.571577375171679 0.943788491349873 -0.233448333667287 0.92580658194919 0.994026707431102 -0.0484917318856526 "CDK4 MUT" "EHT.1864_IC_50" 0.973334858452145 0.995472410100622 -0.0142360544217687 0.571810050252386 0.943788491349873 -0.239144506681137 0.910837687259743 0.990141873133243 0.0490922200402736 "EZH2 MUT" "BAY.61.3606_IC_50" 0.990173695817237 0.998036562927507 -0.00895293283208001 0.571822688914673 0.943788491349873 0.285589275587703 0.852722766780382 0.984631915507353 0.136450613003267 "TET2 MUT" "Bortezomib_IC_50" 0.865463931072238 0.967741687593997 0.22136986916951 0.571844076615709 0.943788491349873 -0.607116680036337 0.502109810322193 0.934042323734638 -1.01680621561729 "SMARCA4 MUT" "AZ628_IC_50" 0.441841725460996 0.825166478070376 1.20364745506256 0.571936242753885 0.943788491349873 0.659413233768551 0.282228011884417 0.887872038823822 2.49413340526267 "RUNX1 MUT" "Cytarabine_IC_50" 0.334797470345813 0.773264085106582 -1.10746109759188 0.572109432968046 0.943788491349873 -0.491006629234751 0.287805915202652 0.888563331668781 -1.12073131333544 "BRAF MUT" "JNJ.26854165_IC_50" 0.704485155712164 0.915500829364901 -0.0632000955337953 0.572123208006904 0.943788491349873 -0.0969958187813839 0.771184174161796 0.969901216545994 0.0540322418601708 "NOTCH1 MUT" "A.770041_IC_50" 0.835885478883434 0.959122768755193 0.156108150877194 0.572260008480483 0.943788491349873 0.364225812799193 0.564736210351879 0.949294892873838 -0.47541555118434 "RUNX1 MUT" "JNK.Inhibitor.VIII_IC_50" 0.634061384323757 0.89399270048764 -0.314862455470744 0.572301101604903 0.943788491349873 -0.355497167711034 0.664749026573374 0.959206771190239 -0.286404147322797 "KIT MUT" "Pazopanib_IC_50" 0.165539351882425 0.64339386611283 -1.17261368356644 0.572359110598586 0.943788491349873 -0.407449867187348 0.589182233235267 0.949294892873838 -0.418221473632489 "SMAD4 MUT" "PF.4708671_IC_50" 0.610571155235851 0.884818029552257 -0.120894795843967 0.572443329441817 0.943788491349873 -0.136990501397057 0.54502424942537 0.946853280734584 -0.154704543503077 "PIK3R1 MUT" "AP.24534_IC_50" 0.996355091289481 0.998977896287767 0.00480817888198771 0.572479293199163 0.943788491349873 -0.534253639186595 0.932699753532872 0.994275178385 -0.0832660025723106 "KDM6A MUT" "Roscovitine_IC_50" 0.950458880343515 0.991778324090091 0.0294844775296382 0.572684304205959 0.943951244553288 0.236845629488663 0.896540024237212 0.988301482344111 -0.0677440766812962 "MLL_AFF1 MUT" "FTI.277_IC_50" 0.841882062868232 0.960035259416123 -0.155700989655172 0.573069790927577 0.944411358921471 -0.407398619685057 0.524554394217181 0.940554660491705 -0.47435363101943 "GNAS MUT" "NU.7441_IC_50" 0.216208636060336 0.688666274325955 0.630059254491013 0.573345658629663 0.944690685397038 0.251086508158987 0.490060594106867 0.933639405738697 0.338368500435173 "NRAS MUT" "Lapatinib_IC_50" 0.156742800992109 0.632454709500646 0.583417757352939 0.573513564739702 0.944709957235654 0.207499490732737 0.746310854122721 0.968371047127272 0.131656572282858 "FGFR2 MUT" "Salubrinal_IC_50" 0.0787558302148116 0.487563291901206 1.75006198630136 0.573570103526027 0.944709957235654 0.474067796323605 0.697731964486437 0.961100601384891 0.469842420201975 "FGFR3 MUT" "X681640_IC_50" 0.64013771624241 0.895849835794019 0.540186981744413 0.573896727935135 0.945072657294999 0.555496025643967 0.884051892398525 0.988301482344111 0.157707126337888 "CDK4 MUT" "GDC0941_IC_50" 0.435082383237784 0.823150425912549 0.476806507638884 0.5744757233631 0.94531919279198 -0.276876464955497 0.641859882953013 0.955267111495758 0.298007866227971 "APC MUT" "FTI.277_IC_50" 0.729188814400614 0.927251698266302 0.0693694427272731 0.574551182966765 0.94531919279198 0.107166745306735 0.882435006548595 0.988301482344111 -0.0343444287658654 "FAM123B MUT" "BAY.61.3606_IC_50" 0.735517766736147 0.928872455997232 0.290027489510493 0.574560751258973 0.94531919279198 -0.334551546996753 0.934357124960295 0.994729228933513 -0.0673285672067674 "MLH1 MUT" "SB590885_IC_50" 0.886088657683794 0.974449243426767 -0.0832947222222224 0.574575155065776 0.94531919279198 0.277425960742015 0.578685959295548 0.949294892873838 0.285992474811231 "HRAS MUT" "AZD6244_IC_50" 0.540782048527054 0.861616652986104 0.615865029045644 0.574722850682206 0.94531919279198 0.515358330095178 0.240028017056373 0.875707386589409 1.05453210331621 "MDM2 MUT" "Bryostatin.1_IC_50" 0.816356928044144 0.955087060724548 0.0933923439153437 0.575205411218979 0.94531919279198 0.212115510157337 0.390303298992976 0.915926348152589 0.32889831024707 "SMARCB1 MUT" "FTI.277_IC_50" 0.328008858680042 0.769735904120651 -0.763138403448276 0.575258249066422 0.94531919279198 -0.396970075961379 0.414344667792369 0.92211126027385 -0.611905944205572 "CDK4 MUT" "CGP.082996_IC_50" 0.591288984585449 0.877253169412525 0.623041462585035 0.5752609233171 0.94531919279198 0.551622757456456 0.284770566366449 0.8879937007725 1.2329595965967 "GNAS MUT" "Metformin_IC_50" 0.353236301348035 0.785062892590933 0.508481683575537 0.575473215468417 0.94531919279198 0.285921690414228 0.308814404758153 0.89718581932126 0.547069327517937 "BCR_ABL MUT" "NU.7441_IC_50" 0.299169664891425 0.750344870252218 -0.859684179183143 0.57563169431531 0.94531919279198 0.525061355008168 0.971386380861492 0.99742775226181 -0.0294346454262518 "KDM5C MUT" "Imatinib_IC_50" 0.818189007287934 0.955165737441734 0.160937322033899 0.575652290887293 0.94531919279198 0.388686777128898 0.900110822786733 0.988704788932507 0.0924772376256796 "IDH1 MUT" "DMOG_IC_50" 0.844299185242466 0.960498931426639 0.24899706896552 0.575671670548105 0.94531919279198 0.635019758000621 0.768268828812335 0.969901216545994 0.354561926320605 "KDM5C MUT" "TW.37_IC_50" 0.364551176410774 0.787388571741174 -0.708458521348325 0.575911533258341 0.94531919279198 -0.397539455240487 0.497115145881163 0.934008720636554 -0.506530654571956 "BRCA2 MUT" "FTI.277_IC_50" 0.958266081819962 0.993340772343095 -0.0236632187500008 0.575999715439322 0.94531919279198 -0.231536679619666 0.628704617647586 0.952332544657719 -0.209541380982282 "EZH2 MUT" "BMS.708163_IC_50" 0.478138854042434 0.836304203722611 -0.432278395739917 0.576050405485906 0.94531919279198 -0.341229524337275 0.528600245793481 0.943054040048671 -0.387940343601634 "NF2 MUT" "RDEA119_IC_50" 0.559837455778182 0.869704664436116 -0.303940841857732 0.576188113336299 0.94531919279198 0.266892961312481 0.625571113623151 0.951047873847153 0.232517146784401 "EP300 MUT" "Bleomycin_IC_50" 0.374474300782387 0.794293352101356 -1.69505165505225 0.576486439732304 0.94531919279198 -0.873232427656501 0.357601131877021 0.91161229252998 -1.68240731739045 "EP300 MUT" "Z.LLNle.CHO_IC_50" 0.434657412556818 0.823150425912549 -1.00582723469388 0.576536694778773 0.94531919279198 -0.662259963850428 0.652368445358601 0.958313128388245 -0.565108748190973 "MSH2 MUT" "BMS.536924_IC_50" 0.574193539435244 0.872620551543038 0.572676982817872 0.576567115189168 0.94531919279198 0.421942283163164 0.817727251597442 0.977383317127464 0.227440141044009 "NRAS MUT" "JNK.Inhibitor.VIII_IC_50" 0.9313893249329 0.986689293492114 -0.0167709608383894 0.57659294162035 0.94531919279198 0.106271791780898 0.838890573970034 0.981704379975756 0.0454496502686619 "GNAS MUT" "OSI.906_IC_50" 0.347114796061445 0.782020929432191 0.611108035273366 0.57662227719392 0.94531919279198 0.343047966607628 0.480951980574038 0.930456985059316 0.463731673849714 "EP300 MUT" "VX.702_IC_50" 0.871753917253669 0.970309741812243 0.140067922243468 0.576623544730608 0.94531919279198 -0.397761065040296 0.829137880363183 0.981081757090089 -0.173129855859113 "PDGFRA MUT" "FH535_IC_50" 0.940245431590193 0.989446598697723 -0.0535304423076923 0.576627989297225 0.94531919279198 0.341823787201465 0.428155941429816 0.922428741067589 0.550439960441388 "STK11 MUT" "PD.0332991_IC_50" 0.0831069112037489 0.498552626562699 0.798118167004054 0.576804146888775 0.94531919279198 0.206114698608584 0.0845333377502109 0.747749574262573 0.799527382982925 "SMO MUT" "BAY.61.3606_IC_50" 0.62827374863248 0.891895646036614 -0.655517906086959 0.57687165475851 0.94531919279198 0.522728062698099 0.218286851305491 0.860928912580141 -1.55743169109571 "CCND1 MUT" "Dasatinib_IC_50" 0.931583124189999 0.986689293492114 -0.0989292840375595 0.576945015279961 0.94531919279198 -0.539850206356832 0.544254575427802 0.946853280734584 0.706665175977894 "FLCN MUT" "ABT.888_IC_50" 0.964175102299908 0.994434372972651 0.0274948333333341 0.576993452074161 0.94531919279198 -0.287878392643362 0.639550010637547 0.954756033698446 -0.461741869813149 "FLCN MUT" "PF.562271_IC_50" 0.570481008041593 0.872389778906173 0.391039512998263 0.57703463468462 0.94531919279198 -0.312924020738793 0.416472918582521 0.922398153848459 0.706592543094695 "MLH1 MUT" "Vinblastine_IC_50" 0.351275664227444 0.784966682190403 0.50718312530712 0.577133280409651 0.94531919279198 0.221448190176708 0.0788661425625264 0.741811190933953 0.904053991188612 "MYC MUT" "JNJ.26854165_IC_50" 0.551354458203568 0.865580796066258 -0.122721477911646 0.577309639057647 0.945342522631612 -0.107362053133556 0.181336062827345 0.84916206298285 -0.274956471438463 "FLT3 MUT" "GDC0941_IC_50" 0.135740319344066 0.60335156031289 1.91770005954828 0.57743379788174 0.945342522631612 0.580123890635559 0.0808271035148064 0.741811190933953 2.2237452502894 "FLT3 MUT" "Bryostatin.1_IC_50" 0.663033503057908 0.903526384925934 -0.2755889864747 0.577486124678156 0.945342522631612 -0.335609668025396 0.319196002280213 0.900918773778407 -0.60577545498557 "FGFR2 MUT" "Cyclopamine_IC_50" 0.21030650590462 0.684261946425694 1.07329828178694 0.577591476779817 0.945342522631612 0.44956317565265 0.814594617902409 0.977383317127464 0.245985111084163 "CDKN2A MUT" "AZD7762_IC_50" 0.0219294887227764 0.270494151870802 -0.357256396816878 0.577716050240891 0.945342522631612 0.0707415839162032 0.461682929063711 0.929276781658587 -0.118958418756853 "FGFR2 MUT" "RDEA119_IC_50" 0.459131705485464 0.828966839128293 1.22652249108912 0.578245829494574 0.945342522631612 0.840502567313797 0.9021662466547 0.988746233284632 0.245764243284031 "NF1 MUT" "VX.680_IC_50" 0.346997577251294 0.782020929432191 0.728144139671363 0.578376647178399 0.945342522631612 -0.282247444776639 0.364823831234608 0.913900497593792 0.836323163000219 "FLCN MUT" "Obatoclax.Mesylate_IC_50" 0.0716039100824378 0.474209042089583 1.8611947062937 0.578406536517454 0.945342522631612 0.421747261849418 0.319608295415142 0.900918773778407 1.26896612929966 "BRCA1 MUT" "VX.680_IC_50" 0.479398855128801 0.836304203722611 1.31880227551021 0.578597715159682 0.945342522631612 0.672907052644985 0.576928191252116 0.949294892873838 1.0888789785521 "FGFR2 MUT" "XMD8.85_IC_50" 0.344828323295941 0.780357971301188 0.997359896907215 0.578649870860406 0.945342522631612 -0.518590892367246 0.417016504347979 0.922428741067589 -1.02771996069117 "TET2 MUT" "A.443654_IC_50" 0.817496988015211 0.955165737441734 -0.271570987485777 0.578654640706964 0.945342522631612 0.428694017695275 0.93489050758498 0.994729228933513 -0.119778624978921 "PIK3R1 MUT" "NVP.BEZ235_IC_50" 0.279748645003908 0.737882141891724 0.594104186116706 0.578732392529681 0.945342522631612 0.220312120791067 0.520983879632037 0.939635632721979 0.333778508152123 "EZH2 MUT" "Mitomycin.C_IC_50" 0.768848707094143 0.938868331695358 -0.247642852130329 0.578748189642719 0.945342522631612 -0.365428382004782 0.411141603083143 0.921714070263062 -0.724800505552845 "MLL_AFF1 MUT" "SB590885_IC_50" 0.568855184634184 0.872389778906173 -0.734607520242916 0.578849727332467 0.945342522631612 0.608856702866078 0.480236890227807 0.930304161706959 0.806186141626942 "RB1 MUT" "Gefitinib_IC_50" 0.181743292581065 0.658636992153339 -0.301477251702173 0.578882051250076 0.945342522631612 -0.115534755829656 0.0265094473069882 0.585472903331568 -0.498372507617369 "ALK MUT" "ABT.888_IC_50" 0.5587698659651 0.869163612542691 -0.437856712380956 0.579074437397591 0.945342522631612 -0.351111459289367 0.856816826325982 0.984749141685459 -0.127193313204804 "VHL MUT" "QS11_IC_50" 0.657977534018049 0.901751651084414 -0.309087239894551 0.579123044205947 0.945342522631612 -0.286144151984328 0.262622361290788 0.877052916121269 -0.826956872767986 "EZH2 MUT" "X681640_IC_50" 0.41746907552539 0.814099702076568 -0.663669830448061 0.579201868939796 0.945342522631612 -0.385478575523651 0.462345985756405 0.929276781658587 -0.563372228529492 "GNAS MUT" "LFM.A13_IC_50" 0.551543871198952 0.865580796066258 0.210049594356261 0.579308392002588 0.945342522631612 0.184084771542724 0.784000671530056 0.974078058737889 0.097023704545352 "HRAS MUT" "AZD7762_IC_50" 0.361732779606625 0.787196475296847 -0.669086373640441 0.579397316319155 0.945342522631612 -0.318866853344472 0.360334177263562 0.91161229252998 -0.610601398732291 "CDKN2C MUT" "Docetaxel_IC_50" 0.273792648232711 0.73402283606276 -0.704376078125001 0.579445752238892 0.945342522631612 -0.266735435456694 0.331310516680767 0.902810042912437 -0.645213581205538 "CCND1 MUT" "Imatinib_IC_50" 0.976962923980095 0.996276778834563 0.011834268292683 0.579532272584584 0.945342522631612 -0.228057035591477 0.374259820971904 0.913948248824328 -0.447622478277464 "CCND3 MUT" "ATRA_IC_50" 0.891343790139629 0.975972789421281 0.166945429389312 0.579595770265637 0.945342522631612 -0.532799663351633 0.786284912085604 0.974870348210561 -0.289073161617815 "FLCN MUT" "WZ.1.84_IC_50" 0.328112435141461 0.769735904120651 0.950068555176333 0.5798283286143 0.945548179659126 0.447046793244177 0.814273812743732 0.977383317127464 -0.383026782969564 "KDR MUT" "PF.562271_IC_50" 0.946698082637739 0.990414144411092 -0.0593927478411049 0.580461600055163 0.945719914855513 0.39936454777365 0.865410854004748 0.987077901072027 0.149345904807985 "CCND3 MUT" "AS601245_IC_50" 0.820858334449971 0.956196598668703 0.20465776265271 0.580486887377721 0.945719914855513 0.400360241928963 0.455099836772326 0.925809648901546 0.66770087585985 "BRCA2 MUT" "Epothilone.B_IC_50" 0.797603410839769 0.949524851900765 0.245656080560421 0.580592517545412 0.945719914855513 -0.302288652506783 0.893670668537014 0.988301482344111 0.126134129400574 "MET MUT" "RDEA119_IC_50" 0.386669858612404 0.79929668582732 0.646507770623738 0.58060168872158 0.945719914855513 0.373558443757531 0.0522151889914673 0.690946762417053 1.23275346928943 "BRCA1 MUT" "Bryostatin.1_IC_50" 0.746715786551586 0.931110103613801 0.204280917975572 0.580683668631371 0.945719914855513 0.329771544069396 0.654247708721621 0.958313128388245 0.272646835197811 "EP300 MUT" "Salubrinal_IC_50" 0.86846227262725 0.968770736448595 -0.202105460750854 0.580793949708771 0.945719914855513 0.555426417447532 0.875714219425695 0.987838063957761 -0.189658462567965 "CDK6 MUT" "OSI.906_IC_50" 0.316620415899715 0.761258739353268 0.726415020210898 0.58086295733872 0.945719914855513 0.380231738465704 0.528376440584553 0.943054040048671 0.491368754842217 "PIK3CA MUT" "AZ628_IC_50" 0.877082563647383 0.971606616908121 -0.118376541723295 0.580911128684694 0.945719914855513 -0.314630938762319 0.70137293070324 0.961100601384891 -0.277895116624972 "BCR_ABL MUT" "AZD8055_IC_50" 0.0652109128434503 0.457742485196035 -1.31171440755469 0.58103238474669 0.945719914855513 -0.373654015371586 0.449844830423336 0.925809648901546 -0.537703725991396 "CCND3 MUT" "Cytarabine_IC_50" 0.771008449682455 0.939898671414565 -0.409083897533204 0.581052855793295 0.945719914855513 -0.587835499005251 0.869540397504407 0.98753907730331 -0.21264996509804 "VHL MUT" "Pazopanib_IC_50" 0.325778391289107 0.767437106906781 -0.658933377855886 0.581105007923267 0.945719914855513 0.316403653393974 0.768532555427211 0.969901216545994 0.195439852152966 "BRCA2 MUT" "Lenalidomide_IC_50" 0.343771829323853 0.780249349533262 0.451398301526723 0.581265869028523 0.945808388208559 0.232486131277109 0.331636938139192 0.902810042912437 0.448005880103732 "FGFR3 MUT" "BIBW2992_IC_50" 0.753928270354579 0.933869109446012 -0.421162779886146 0.581654796990944 0.946241991069955 -0.708849202591926 0.861692130797995 0.985536099628718 -0.21558718817017 "SMARCA4 MUT" "JNJ.26854165_IC_50" 0.605464457087392 0.882603260686518 0.188171872146118 0.581761966071805 0.946241991069955 0.1856254744075 0.371899128244787 0.913948248824328 0.351744988040466 "MS-HL MUT" "BI.D1870_IC_50" 0.296078395718728 0.747305163324792 -0.225662870244936 0.582017753514911 0.946241991069955 -0.102869209518664 0.28785009629671 0.888563331668781 -0.238695814903612 "PDGFRA MUT" "Camptothecin_IC_50" 0.569402139834241 0.872389778906173 -0.57437543320611 0.582095924844297 0.946241991069955 -0.350662691985362 0.540235495022582 0.944806105261359 -0.553963414509247 "FGFR3 MUT" "CI.1040_IC_50" 0.601276673961455 0.880741900288913 0.661932536259562 0.582158926145606 0.946241991069955 0.622366722693251 0.781811734935299 0.9732646506813 0.308407629217994 "ERBB2 MUT" "Etoposide_IC_50" 0.086709828110539 0.507961730507715 1.0314770854763 0.582317906952047 0.946241991069955 0.221617488562837 0.544466476237345 0.946853280734584 0.36701853915371 "MS-HL MUT" "OSI.906_IC_50" 0.876533491092718 0.971594429690931 -0.0406301753109674 0.582325624090113 0.946241991069955 0.137150282297734 0.382747698434065 0.915134825237766 0.25529631289016 "NOTCH1 MUT" "CI.1040_IC_50" 0.260733240475786 0.724105426777921 -0.544465215680805 0.582384722800177 0.946241991069955 -0.248773622518832 0.414866310368141 0.92211126027385 -0.37825626644029 "FLCN MUT" "CGP.60474_IC_50" 0.67114862038802 0.906916702390321 0.458202179749714 0.582680183670136 0.946460082105181 -0.44063190267325 0.454963360359349 0.925809648901546 -1.38538054467771 "CDK4 MUT" "SB.216763_IC_50" 0.988646011129111 0.998036562927507 0.00661348514851386 0.58273209424064 0.946460082105181 -0.247073902297339 0.914184664413665 0.990992087087848 -0.0506597533302095 "CDKN2C MUT" "AZD6482_IC_50" 0.825434900731275 0.957177484110155 -0.138338547202799 0.582909002842592 0.946570518219895 -0.291850810348174 0.648862461015252 0.957493413330814 0.332801661409256 "BRCA1 MUT" "PD.0332991_IC_50" 0.775362227568257 0.941591338606299 0.282384200828153 0.583119713805908 0.946570518219895 -0.435252565509489 0.977195082291138 0.99742775226181 -0.0263648614760229 "EZH2 MUT" "Methotrexate_IC_50" 0.93428985200101 0.987517726433927 -0.0916991247484908 0.583119840691482 0.946570518219895 0.46243646308723 0.822127715517054 0.977637136298011 0.197693460996013 "EGFR MUT" "SB590885_IC_50" 0.422225660860448 0.816946861460052 0.325620978947367 0.583574340731278 0.94666675357961 0.187361914891976 0.668059222511718 0.959230524020512 0.159896471900395 "CDK6 MUT" "GDC.0449_IC_50" 0.516010044325103 0.852353345422823 0.266821445966513 0.58359110843904 0.94666675357961 0.200381475820568 0.7186715733082 0.964721180904622 0.146473941479346 "MAP2K4 MUT" "Pyrimethamine_IC_50" 0.741015227459032 0.929570057037101 -0.386789812286689 0.583637288276382 0.94666675357961 -0.545505164202518 0.887267488470689 0.988301482344111 -0.194038615735438 "BCR_ABL MUT" "BMS.509744_IC_50" 0.72993891595564 0.927541495579058 -0.30099822525597 0.583827217958282 0.94666675357961 0.367758254389671 0.793038694472112 0.975393509832241 0.228696390922995 "CCND3 MUT" "AZD.2281_IC_50" 0.414944602816938 0.814032033933559 0.864604931102376 0.583849151113943 0.94666675357961 0.438352106098409 0.55115176484393 0.947060194029534 0.552899455786457 "MAP2K4 MUT" "BMS.708163_IC_50" 0.70423235306033 0.915500829364901 -0.14734449318182 0.583980975980581 0.94666675357961 -0.213309344351608 0.455862316859459 0.925809648901546 -0.310737716554621 "MYC MUT" "IPA.3_IC_50" 0.446491050242004 0.825892730562573 0.249042173939553 0.584100719509482 0.94666675357961 0.151479890442871 0.373056391038126 0.913948248824328 0.286288497916239 "KRAS MUT" "Lenalidomide_IC_50" 0.390134689439352 0.801837403580487 0.107459186833954 0.58411487967055 0.94666675357961 -0.0638159226819431 0.638152728213677 0.953445720127982 0.0655205005557862 "MLL_AFF1 MUT" "JW.7.52.1_IC_50" 0.418536510762456 0.814099702076568 -1.5431885762712 0.584261376288152 0.94666675357961 0.642800473029524 0.422362278885492 0.922428741067589 -1.55992854518712 "MYCL1 MUT" "PF.4708671_IC_50" 0.573409448038905 0.872620551543038 0.297473747178325 0.58449173389334 0.94666675357961 0.284684461540739 0.237414445919377 0.873248794735437 0.716247791247849 "IDH1 MUT" "Gemcitabine_IC_50" 0.699286166864536 0.914968665673257 -1.10885433391305 0.584581974843627 0.94666675357961 1.04624918766982 0.924932214535212 0.994026707431102 -0.254862582230994 "TSC1 MUT" "Bryostatin.1_IC_50" 0.830951052476476 0.958562510266249 0.190630523478263 0.584666063935436 0.94666675357961 -0.460094002649257 0.96861675120417 0.997173634484198 0.033473437962221 "CDKN2a(p14) MUT" "JNK.Inhibitor.VIII_IC_50" 0.98535825462126 0.996887811168928 -0.00187858217821764 0.584670285257068 0.94666675357961 0.0554773944598009 0.649096935380237 0.957493413330814 0.0525235691903098 "FBXW7 MUT" "PD.173074_IC_50" 0.178277112896683 0.65750790682535 -0.422194164818925 0.584671449542187 0.94666675357961 -0.14746841490752 0.354025969779811 0.911252930312559 -0.285917845547438 "BRAF MUT" "CGP.082996_IC_50" 0.623719343980112 0.889924295824892 -0.18164065974026 0.584852214621995 0.946786824290546 -0.185731198102883 0.392040457820612 0.915926348152589 -0.40386453786337 "MDM2 MUT" "GDC0941_IC_50" 0.190163583250084 0.664991779417723 0.799855754861109 0.585346350124706 0.947370618148955 0.268052316787235 0.140372250916091 0.831473272394224 0.888384691070709 "RB1 MUT" "XMD8.85_IC_50" 0.374240694376724 0.794193236181393 0.259536868863955 0.585527156114735 0.947370618148955 0.14163641832382 0.350233374700394 0.910340341961272 -0.316039930925842 "NOTCH1 MUT" "Erlotinib_IC_50" 0.392097273825033 0.803073858340542 0.498407512437809 0.585670630686806 0.947370618148955 0.300136741893427 0.916490861639 0.992403322408462 0.0701284579118776 "MDM2 MUT" "Nilotinib_IC_50" 0.618243845308517 0.88687184464302 0.260647173410405 0.585997068717375 0.947370618148955 -0.231272338264806 0.643570894260761 0.955972780483685 0.216509691761293 "BCR_ABL MUT" "CI.1040_IC_50" 0.111347347816433 0.56218066853766 -1.42727562452105 0.586016639076541 0.947370618148955 0.531567351679654 0.452740285628393 0.925809648901546 -0.611807977087377 "MLL_AFF1 MUT" "BAY.61.3606_IC_50" 0.0356027493383547 0.347105523744792 -2.84003488869569 0.586021162497567 0.947370618148955 0.522411981428807 0.28378649787807 0.8879937007725 -1.37092524848244 "MYCL1 MUT" "IPA.3_IC_50" 0.699237509928963 0.914968665673257 0.25439299118166 0.586098913125917 0.947370618148955 0.300945094944347 0.377773316723994 0.914419412871569 0.589289847554828 "JAK2 MUT" "RO.3306_IC_50" 0.885811407526259 0.974449243426767 -0.0866785958005226 0.586260148930975 0.947370618148955 -0.313181144645054 0.442617577277753 0.925132196705984 -0.510857726210194 "EZH2 MUT" "Sunitinib_IC_50" 0.152250028948411 0.625830613280407 1.69609067465754 0.586273794204027 0.947370618148955 0.474521641574837 0.0031859842107429 0.301007721017103 3.4792946965673 "PIK3CA MUT" "CGP.60474_IC_50" 0.643278640759505 0.896290807747908 0.244295644468604 0.586343580611803 0.947370618148955 0.214232537429541 0.742152450038679 0.96672489654949 0.185321380669865 "BRCA1 MUT" "Midostaurin_IC_50" 0.548811678108503 0.864873049004332 -0.503083225303289 0.586421779224869 0.947370618148955 -0.35204076212325 0.318551254191413 0.900918773778407 -0.762752235189427 "CDKN2a(p14) MUT" "AS601245_IC_50" 0.0319497733275456 0.329263246012996 -0.334710872986028 0.586496156170433 0.947370618148955 0.0710348196486345 0.969703510005506 0.997173634484198 0.00655095283735798 "MYC MUT" "Axitinib_IC_50" 0.505505392414332 0.847695126516556 0.192503473210714 0.586610282839597 0.947370618148955 -0.133456316028945 0.221375785878634 0.864953081560998 0.324636915537508 "MSH2 MUT" "Thapsigargin_IC_50" 0.764811888296689 0.936738984962474 -0.327367458145368 0.586778683492159 0.947370618148955 0.457093381177733 0.668761026309754 0.959230524020512 -0.459308651963482 "GNAS MUT" "CHIR.99021_IC_50" 0.589766845331472 0.876506729771444 0.24673198951049 0.586987941875515 0.947370618148955 0.235297118838415 0.99949499875302 0.999751228014461 0.000281717300908476 "EZH2 MUT" "X17.AAG_IC_50" 0.573742495616291 0.872620551543038 0.55474722030651 0.587022976597746 0.947370618148955 0.468777775840796 0.509453313535903 0.938202304953595 0.569515133688022 "CDH1 MUT" "Gemcitabine_IC_50" 0.219466553703822 0.692453909775927 1.67087581416277 0.587133285543179 0.947370618148955 0.501553375276967 0.571418883092064 0.949294892873838 0.772687083605409 "FGFR3 MUT" "Cisplatin_IC_50" 0.530700567240672 0.856734402332693 -0.736358874762804 0.587139617819619 0.947370618148955 -0.552035647675053 0.494559386835572 0.933639405738697 -0.76621123973851 "BRAF MUT" "EHT.1864_IC_50" 0.253611811503465 0.718674696222806 0.211017332826385 0.587239641133881 0.947370618148955 -0.110254996519651 0.189752308562199 0.851001889249827 0.277728577558129 "CDK4 MUT" "MS.275_IC_50" 0.936955706870096 0.988375382416448 0.123110877133107 0.587700379742027 0.947820375579213 0.706149915156976 0.728032690609269 0.965402608571648 0.565550103828988 "MLH1 MUT" "ABT.888_IC_50" 0.129997417848902 0.592095424437004 -0.487247077871739 0.587834965644082 0.947820375579213 -0.149011712885882 0.574193202343578 0.949294892873838 -0.170785247311244 "TSC1 MUT" "NSC.87877_IC_50" 0.362451889053872 0.787270200866664 0.721876551724147 0.587838602487367 0.947820375579213 0.422436630577454 0.377629926736388 0.914419412871569 0.707768373460743 "MYCL1 MUT" "Lenalidomide_IC_50" 0.487073444472253 0.840863415759626 0.262765547024952 0.587948441962252 0.947825397180388 0.179515404981043 0.415194186123022 0.92211126027385 0.323565567715406 "MS-HL MUT" "AUY922_IC_50" 0.0729609550865044 0.476796351819901 -0.435014070324094 0.588385159204758 0.947844814957618 -0.0889160579723933 0.0113269867753902 0.451098518171481 -0.652729068238224 "KDM5C MUT" "Nutlin.3a_IC_50" 0.701018695138639 0.915500829364901 -0.414804410958909 0.588445585089081 0.947844814957618 -0.535258898909926 0.574963870432173 0.949294892873838 -0.582339580602431 "MS-HL MUT" "A.770041_IC_50" 0.503132968449414 0.846758664699095 0.290926428015565 0.58849716552721 0.947844814957618 0.191741580722152 0.263177235697614 0.877052916121269 0.523947721899514 "SMARCA4 MUT" "AS601245_IC_50" 0.580311478514264 0.875296576203325 0.303177903629941 0.588990556723243 0.947844814957618 0.236043901206198 0.429088627585823 0.922428741067589 0.481613062205104 "CDK4 MUT" "VX.702_IC_50" 0.651752752165882 0.899243470992269 0.215920678294572 0.589072015833229 0.947844814957618 -0.211792566250348 0.973352383713237 0.99742775226181 -0.0155811911772434 "JAK2 MUT" "MK.2206_IC_50" 0.873012540219021 0.970487466477047 -0.128281145228213 0.589130445079797 0.947844814957618 -0.344816451077637 0.455006765894392 0.925809648901546 -0.656078059247145 "MLH1 MUT" "Bosutinib_IC_50" 0.893911567880488 0.976022725555062 -0.073030628787878 0.589224761295482 0.947844814957618 0.245481883313519 0.477709017276711 0.930304161706959 0.362840949770493 "SMARCA4 MUT" "NU.7441_IC_50" 0.398022042982949 0.805826318300581 0.386058705410821 0.589285281383002 0.947844814957618 0.215296493683488 0.500475228696997 0.934042323734638 0.338170614647399 "RB1 MUT" "VX.680_IC_50" 0.592223524856524 0.877813673424837 -0.232231839783067 0.589453651971165 0.947844814957618 -0.156848241429624 0.141361131545484 0.831473272394224 -0.770420854654931 "CCND2 MUT" "AP.24534_IC_50" 0.48395180654861 0.83936150279118 1.12123706390327 0.589623636395345 0.947844814957618 0.772770599579886 0.661101590453948 0.958689538788368 -0.806956708196637 "MLLT3 MUT" "Dasatinib_IC_50" 0.573532544621528 0.872620551543038 -0.707812902097899 0.589804135192739 0.947844814957618 -0.554279829073642 0.596723928819007 0.949294892873838 -0.610917946759346 "VHL MUT" "NU.7441_IC_50" 0.332830894450381 0.773185226006147 -0.493537926147694 0.589836768192668 0.947844814957618 -0.242057623894433 0.882683653582639 0.988301482344111 -0.0785625288164546 "MLL_AFF1 MUT" "BMS.509744_IC_50" 0.165993157254858 0.644593454123477 -1.69969010169493 0.58998802515456 0.947844814957618 0.502516493586228 0.387337047188274 0.915785792511616 -1.04714138036367 "FLCN MUT" "Lenalidomide_IC_50" 0.839644395433744 0.959424448728358 0.107806952380952 0.590022726338185 0.947844814957618 -0.251736527217206 0.960377399047609 0.996507965993903 -0.0357743652387864 "CCND2 MUT" "JNK.9L_IC_50" 0.929357633940798 0.986689293492114 -0.070483248704663 0.590162434898526 0.947844814957618 -0.332518854226903 0.711929126225744 0.962630898212352 -0.355795278752641 "VHL MUT" "AKT.inhibitor.VIII_IC_50" 0.0869601170949777 0.508756785191368 -0.974588627613223 0.590183810452772 0.947844814957618 -0.264273478751776 0.141210146183783 0.831473272394224 -0.887166230893278 "ALK MUT" "BAY.61.3606_IC_50" 0.837324184927282 0.959212493377535 -0.278009384347827 0.590236113330755 0.947844814957618 0.509146879025697 0.880592380328706 0.988301482344111 0.269077392751784 "MLH1 MUT" "Bleomycin_IC_50" 0.589345096873703 0.876506729771444 -0.519309594395283 0.590246145712673 0.947844814957618 -0.426133591265459 0.996967152605637 0.999545005862799 0.00354759014750029 "CDKN2a(p14) MUT" "Gefitinib_IC_50" 0.972127591028024 0.995220468612913 0.00507698826717524 0.590268894624372 0.947844814957618 0.0730203743236216 0.887560009434167 0.988301482344111 -0.0206626035257768 "NF2 MUT" "GSK.650394_IC_50" 0.46832785868949 0.831405016816516 -0.335433686365196 0.590325190105557 0.947844814957618 0.162270564010921 0.90539635126558 0.988917021334873 0.0590165244670538 "STK11 MUT" "NVP.TAE684_IC_50" 0.31226365046788 0.759215564942334 -1.11785554576271 0.590347558323669 0.947844814957618 -0.489852861866861 0.399711343999691 0.916480913435499 -1.06423714031939 "CDK6 MUT" "AG.014699_IC_50" 0.886122293651005 0.974449243426767 -0.0734694295454553 0.590424530745258 0.947844814957618 -0.241904521861194 0.650614931857186 0.957867556929346 -0.21415603788303 "FGFR3 MUT" "LFM.A13_IC_50" 0.951024101077331 0.992018445110145 -0.0393218931475024 0.590592014752696 0.947844814957618 0.324083874476463 0.961690989089184 0.996625877572729 0.0305269285179055 "MLL_AFF1 MUT" "Paclitaxel_IC_50" 0.182089560145958 0.658636992153339 -2.4620133084746 0.590629793893821 0.947844814957618 -0.441758587831955 0.134112342744035 0.827361946088783 -2.76999770048878 "FGFR2 MUT" "Parthenolide_IC_50" 0.159209502299394 0.635849673885708 1.30022560810811 0.590830405050458 0.947844814957618 0.476311828426912 0.696490538639674 0.961100601384891 0.452347138129423 "RB1 MUT" "Mitomycin.C_IC_50" 0.301137409640811 0.751119785777076 -0.299565472306234 0.59090138766634 0.947844814957618 -0.124863910398848 0.0104004065134242 0.450367315182713 -0.816874360545651 "CCND3 MUT" "GW.441756_IC_50" 0.511832688010714 0.850007572343239 0.565181159392785 0.590986980447457 0.947844814957618 0.452668970244234 0.487575593327286 0.933639405738697 0.590117693072585 "CCND3 MUT" "JNK.9L_IC_50" 0.583600979435584 0.876506729771444 -0.377684200692049 0.591005566471247 0.947844814957618 -0.289956850000338 0.612785455255334 0.949930222127033 -0.346162848871674 "EGFR MUT" "Etoposide_IC_50" 0.261054235972412 0.724280746538892 0.585354693007703 0.59111902431483 0.947844814957618 0.182798140385294 0.230896217265923 0.868971729823866 0.620514693721415 "MLL_AFF1 MUT" "AZD8055_IC_50" 0.714061566799202 0.91988693852899 -0.368504241584164 0.591334841028638 0.947844814957618 0.427291345953332 0.548108531153851 0.947060194029534 0.591644647804467 "FBXW7 MUT" "Nutlin.3a_IC_50" 0.906146143764921 0.981251818741413 -0.0479398178122695 0.591406564542367 0.947844814957618 0.200686234144156 0.593562444790832 0.949294892873838 0.224476025750857 "RB1 MUT" "Cyclopamine_IC_50" 0.800505826665243 0.950694336268257 0.0599681626928466 0.591433723230869 0.947844814957618 0.120985584065649 0.0842449538044152 0.747749574262573 -0.482563245510456 "STK11 MUT" "X681640_IC_50" 0.514677976129372 0.851706582334351 0.231723217758988 0.591639706438087 0.947844814957618 -0.163538995907012 0.630507346041867 0.952523560833852 -0.173005080472649 "CDKN2A MUT" "Roscovitine_IC_50" 0.656662857004114 0.901751651084414 -0.0908427577741415 0.591665274115176 0.947844814957618 0.102922104580295 0.758506327118115 0.969901216545994 0.0727858084874654 "MSH2 MUT" "LFM.A13_IC_50" 0.358228464649456 0.786601117838604 -0.386265413533839 0.591792894288124 0.947844814957618 -0.213737476508371 0.147407784051672 0.831473272394224 -0.611864989607228 "HRAS MUT" "LFM.A13_IC_50" 0.742253097567169 0.929570057037101 0.163364860139859 0.59184968863816 0.947844814957618 0.252054511265403 0.402740314431883 0.916850640727267 0.414024855370944 "BRCA2 MUT" "RO.3306_IC_50" 0.821296947242393 0.956293356389236 0.166646745098037 0.591942615252888 0.947844814957618 -0.378549572140252 0.68438759296995 0.961100601384891 -0.300858416644677 "EGFR MUT" "A.770041_IC_50" 0.281841659183509 0.738375640008268 0.884446770034848 0.592043943619839 0.947844814957618 0.355009401078967 0.0597057858826054 0.70215997387469 1.48206139629747 "FGFR2 MUT" "BI.2536_IC_50" 0.0396937147835724 0.361141839503332 2.69752218367348 0.592336717266669 0.947844814957618 0.429881143597629 0.183298486669515 0.851001889249827 2.21026743382934 "TSC1 MUT" "SL.0101.1_IC_50" 0.918018337048896 0.985247232789275 -0.0887468330134364 0.592338541438037 0.947844814957618 0.403954589069234 0.766595102502099 0.969901216545994 0.245631479364431 "FLCN MUT" "QS11_IC_50" 0.0579523013108506 0.43286323628399 1.66760131643356 0.592440304669335 0.947844814957618 0.346206080311322 0.079022515046201 0.741811190933953 1.93800787605081 "EGFR MUT" "RDEA119_IC_50" 0.440260115433331 0.824500931653809 -0.393394412746017 0.592458005510444 0.947844814957618 -0.24778058411214 0.549210989721155 0.947060194029534 -0.273880188989095 "FBXW7 MUT" "Gefitinib_IC_50" 0.108934193721422 0.555860688046234 -0.554240571146241 0.592599038974289 0.947844814957618 -0.167355809833658 0.225044608104591 0.86643108387559 -0.400563106942862 "VHL MUT" "Nilotinib_IC_50" 0.264918792007094 0.726697783882931 0.650360322456802 0.592856816697458 0.947844814957618 0.252954266754955 0.211239898224526 0.855272470862467 0.711096138503836 "FAM123B MUT" "AICAR_IC_50" 0.54523812301333 0.862633715268747 0.520636601941739 0.593007151113906 0.947844814957618 -0.41176086995263 0.889216511067725 0.988301482344111 0.11691377104047 "BRAF MUT" "VX.702_IC_50" 0.375919374182954 0.795051761241315 -0.189004973171201 0.593040785462728 0.947844814957618 -0.0991351009004976 0.417223643719622 0.922428741067589 -0.192078057239242 "MS-HL MUT" "Rapamycin_IC_50" 0.545191125776469 0.862633715268747 -0.313229829944004 0.59316916422153 0.947844814957618 -0.238670460415947 0.869659320294435 0.98753907730331 -0.0971754231830566 "FBXW7 MUT" "GNF.2_IC_50" 0.794458652285157 0.948646027682356 0.110567109175377 0.593272643743026 0.947844814957618 0.218888918792094 0.793255753677665 0.975393509832241 0.116134579390399 "EZH2 MUT" "A.443654_IC_50" 0.106971294448429 0.551794991672845 1.64209354109589 0.593516200230667 0.947844814957618 0.353027963119483 0.0529566082049591 0.694693703793562 2.30586863261056 "FAM123B MUT" "PD.0325901_IC_50" 0.558824932734914 0.869163612542691 -0.76041310912697 0.593524903069809 0.947844814957618 -0.652655603681558 0.620039645318135 0.950496524771391 -0.568463332629503 "NRAS MUT" "BIRB.0796_IC_50" 0.9028451535905 0.979694707150557 -0.0253065030336458 0.593534499829671 0.947844814957618 0.108381701497493 0.812649133445285 0.977383317127464 0.0553695361984121 "SMARCB1 MUT" "AZD6482_IC_50" 0.84322823236996 0.960498931426639 -0.275447149999996 0.593588892890821 0.947844814957618 0.625275286184681 0.433097259453145 0.922569292988365 -1.07901067884639 "HRAS MUT" "TW.37_IC_50" 0.471640088510864 0.833061978135438 -0.436702288939048 0.593629986731411 0.947844814957618 -0.295335811931529 0.586240409592411 0.949294892873838 -0.316111437598615 "TP53 MUT" "AP.24534_IC_50" 0.0864402651098643 0.506983418285915 0.415696236174265 0.593723759217344 0.947844814957618 0.122537674073646 0.87661622692152 0.987838063957761 0.03824231303507 "APC MUT" "WO2009093972_IC_50" 0.00195289053621446 0.0659453264339186 0.943507258172604 0.593909492145757 0.947970920155728 0.154700945127444 0.518014519498084 0.939635632721979 0.238311499005976 "MSH6 MUT" "GSK.650394_IC_50" 0.358082468965313 0.786601117838604 -0.680707400263625 0.594048279023339 0.948022060378485 -0.254687597490729 0.428705182652088 0.922428741067589 -0.580004840771443 "IDH1 MUT" "BMS.754807_IC_50" 0.943456746470338 0.990147156460271 -0.115658481739131 0.594269374875187 0.948204512803905 0.721093448345111 0.784984611026879 0.974755079772051 0.438991657960943 "CTNNB1 MUT" "Bicalutamide_IC_50" 0.397878765509721 0.805826318300581 -0.137163013048637 0.594804348149691 0.948422104231808 -0.0820026521802671 0.293872625416905 0.894167310052 -0.179239354971392 "BRCA2 MUT" "JNK.9L_IC_50" 0.911277759898454 0.982267477694927 -0.0628050746527786 0.595078412895692 0.948422104231808 -0.235766923280444 0.757387726076563 0.969901216545994 -0.174375259429183 "TP53 MUT" "RO.3306_IC_50" 0.720953670368531 0.922822998769296 -0.0491440369631516 0.5952113937394 0.948422104231808 -0.073669060260311 0.480147514435461 0.930304161706959 -0.104483248858038 "FAM123B MUT" "BX.795_IC_50" 0.317638034925174 0.761258739353268 0.924057506423239 0.595216378726054 0.948422104231808 -0.37889202164308 0.870513238121955 0.98753907730331 -0.13377152799975 "MLH1 MUT" "Shikonin_IC_50" 0.192010801630505 0.668023137615267 -0.777927440350877 0.595231709249405 0.948422104231808 -0.269798159737396 0.278282630555749 0.885713545160236 -0.634985605501419 "AKT2 MUT" "GSK.650394_IC_50" 0.119314857083922 0.577057450057752 -1.23146049473685 0.595362176627903 0.948422104231808 -0.270966189469625 0.148303953154259 0.831473272394224 -1.15157729102593 "MDM2 MUT" "Cyclopamine_IC_50" 0.538692087877768 0.861419263046422 0.409836262975778 0.595482736261903 0.948422104231808 0.324937101529117 0.467501649991494 0.929276781658587 0.485797184186423 "EP300 MUT" "Elesclomol_IC_50" 0.401457724514768 0.806415132522709 -1.05779877883395 0.595516499438632 0.948422104231808 -0.556952525961835 0.621535649039623 0.950496524771391 -0.58471548136085 "MET MUT" "BMS.754807_IC_50" 0.93655228959957 0.988375382416448 -0.0557893425955675 0.595588676484791 0.948422104231808 0.311239391528103 0.782944943126941 0.973856308110695 0.189758849980153 "AKT2 MUT" "Embelin_IC_50" 0.504458166298011 0.847595766822021 -0.363329967418549 0.595755055677168 0.948422104231808 0.23067275586464 0.518088124473442 0.939635632721979 -0.352205717158455 "FLT3 MUT" "AZ628_IC_50" 0.569362815779332 0.872389778906173 -0.890692294653005 0.595839771066473 0.948422104231808 -0.626294972174601 0.937557327897391 0.994831655017307 -0.106549424481087 "SMARCA4 MUT" "WO2009093972_IC_50" 0.61980697677948 0.887556792488111 0.244639915492957 0.595841843999032 0.948422104231808 0.232530140128061 0.765437845945634 0.969901216545994 0.166401823934193 "RB1 MUT" "RO.3306_IC_50" 0.660920927902005 0.902400992643984 0.0927350708534624 0.595846446218095 0.948422104231808 0.109213788269221 0.774424725518623 0.971696240086308 0.0671427445777092 "KDR MUT" "IPA.3_IC_50" 0.921749034031404 0.986140039233073 0.117374365853657 0.595900837925176 0.948422104231808 0.532013210073698 0.964682268079964 0.997126446878798 -0.0496825844677201 "MET MUT" "KIN001.135_IC_50" 0.782888604413327 0.944853400298342 -0.151928619528618 0.596178765334396 0.948694430197951 -0.284090450257178 0.939531096202242 0.994831655017307 -0.0392772402882931 "APC MUT" "FH535_IC_50" 0.631322935785491 0.893419864692589 -0.140846558489896 0.596333228232375 0.948770225713314 0.138920548329815 0.599418981767141 0.949657634568742 0.179675195726121 "KDM6A MUT" "Bicalutamide_IC_50" 0.509561940926952 0.849059439813668 -0.0909314765330598 0.596573653681851 0.948982736584008 -0.0698337292330898 0.203599166516794 0.852959543285214 -0.173874508028773 "CCND3 MUT" "Axitinib_IC_50" 0.404109263899506 0.807904911469051 1.05078700569259 0.596915203557509 0.949009909249903 0.562126053544929 0.285517478326725 0.8879937007725 1.17529158918903 "EP300 MUT" "Bexarotene_IC_50" 0.516672794362836 0.852353345422823 -0.60282946747967 0.597049449576872 0.949009909249903 -0.440009857979397 0.754725304659595 0.96972156115189 -0.275947790098866 "VHL MUT" "JNJ.26854165_IC_50" 0.422717106726624 0.817363515096701 -0.347802811791387 0.597240859870898 0.949009909249903 -0.213979779281245 0.714967431572461 0.962630898212352 -0.151985423553163 "KIT MUT" "AZD7762_IC_50" 0.177981220005755 0.656868746076954 -1.20734602533461 0.59727186221692 0.949009909249903 -0.371078698371867 0.127067390328405 0.817150972850516 -1.25420703404714 "TET2 MUT" "Roscovitine_IC_50" 0.459338832351242 0.828966839128293 -0.717865051903118 0.597273628631456 0.949009909249903 -0.457856810740633 0.217347720214371 0.860928912580141 -1.4572032696159 "PDGFRA MUT" "PF.562271_IC_50" 0.393042856110771 0.803073858340542 -0.588590552859613 0.597298682167726 0.949009909249903 -0.295921671437172 0.600325758929714 0.949657634568742 -0.360102312384675 "NOTCH1 MUT" "Roscovitine_IC_50" 0.609024879191461 0.884360685431551 -0.262864898091232 0.597399089686653 0.949009909249903 0.249900359852082 0.315246762055373 0.900294798053993 -0.594582579049473 "EZH2 MUT" "Pazopanib_IC_50" 0.611523838476801 0.88496040166963 0.363887912531333 0.597449070782082 0.949009909249903 0.320593532767713 0.868591617102949 0.98751437004641 0.116585132782187 "BRCA1 MUT" "Lenalidomide_IC_50" 0.90679467217045 0.981251818741413 -0.0623799047619055 0.597552461718889 0.949009909249903 -0.247453525402257 0.724001443945797 0.965402608571648 -0.179680093717662 "CDH1 MUT" "MG.132_IC_50" 0.572331844508814 0.872389778906173 -0.60193860750853 0.597743213430629 0.949143121487112 -0.509788705941573 0.719377397782198 0.964898274809486 -0.365211576879213 "EGFR MUT" "Methotrexate_IC_50" 0.609311697554237 0.884443710620525 0.246844434712468 0.597982030196661 0.949352593882114 0.19475148699818 0.655468197070442 0.958313128388245 -0.179143858637134 "CDKN2C MUT" "ABT.263_IC_50" 0.327986571041734 0.769735904120651 0.75797183992094 0.59823532167086 0.949556813787471 0.368569875779111 0.339867602317609 0.907051943807165 0.687522908097039 "CDKN2A MUT" "Pyrimethamine_IC_50" 0.512910958184002 0.8511140171211 -0.184184380124468 0.598386253664066 0.949556813787471 0.133000789600765 0.925563787823505 0.994026707431102 -0.030592972996951 "FGFR2 MUT" "FTI.277_IC_50" 0.0374827942855455 0.352079059947973 1.14807461245674 0.598938372434055 0.949556813787471 0.269074243931781 0.148159654937903 0.831473272394224 0.874033876716442 "CDK6 MUT" "NVP.BEZ235_IC_50" 0.268100340126377 0.731489745211169 0.574454040546596 0.598960708275347 0.949556813787471 0.196653296267269 0.315460394819797 0.900294798053993 0.493696909562248 "PDGFRA MUT" "Doxorubicin_IC_50" 0.461308233049554 0.828966839128293 -0.645108253496506 0.599022130703475 0.949556813787471 -0.287005225692455 0.449166087708072 0.925809648901546 -0.64120261764846 "KDM6A MUT" "AKT.inhibitor.VIII_IC_50" 0.999211258545211 0.999548905963057 -0.000351850522026904 0.599200037136422 0.949556813787471 0.161285245509385 0.619129488489922 0.950394619652337 0.183026097761386 "STK11 MUT" "Thapsigargin_IC_50" 0.275009570192583 0.73402283606276 0.654626187311638 0.599265310721174 0.949556813787471 0.240909154796044 0.288986355707455 0.889281028047524 0.657520132229335 "CDH1 MUT" "CHIR.99021_IC_50" 0.175555210922171 0.65398734404354 0.652390453752186 0.599399354182087 0.949556813787471 0.243376161386128 0.47900686719471 0.930304161706959 0.352550350898509 "MLL_AFF1 MUT" "Gefitinib_IC_50" 0.251067787495603 0.717470497840808 -1.31944770208727 0.599672465567746 0.949556813787471 0.551943994859182 0.738312060940128 0.96672489654949 -0.350297341048432 "KIT MUT" "MS.275_IC_50" 0.59721857193588 0.879232253518807 -0.822248841296938 0.599910691047109 0.949556813787471 -0.700327493128481 0.692626075649908 0.961100601384891 -0.644739774342987 "BRAF MUT" "VX.680_IC_50" 0.50830246992763 0.848277813132358 -0.393594739913421 0.599948688133115 0.949556813787471 -0.221758080594161 0.206562847684762 0.853446327418758 -0.999503971013533 "NF1 MUT" "GDC0941_IC_50" 0.262788943447818 0.724847082936025 0.443438732528718 0.599981831860405 0.949556813787471 0.168371290776628 0.284565618698676 0.8879937007725 0.457552958017234 "FAM123B MUT" "Bicalutamide_IC_50" 0.783042265964816 0.94486390815673 0.0767209090909102 0.600029662616228 0.949556813787471 0.138942359094555 0.409001038418377 0.920903133902018 0.218501118538425 "GNAS MUT" "AMG.706_IC_50" 0.827648025751377 0.958015830101332 0.0994864328063234 0.600118485795158 0.949556813787471 -0.220333486793844 0.80270133906127 0.976365695720597 -0.105061089450015 "SMAD4 MUT" "CCT018159_IC_50" 0.399351814486328 0.805918367644724 -0.240938145670753 0.600129621773214 0.949556813787471 -0.143098425195744 0.453029442999385 0.925809648901546 -0.229948836648649 "PTEN MUT" "Epothilone.B_IC_50" 0.660231488481958 0.902400992643984 0.120518520133907 0.600140559943897 0.949556813787471 0.0834025212486534 0.615313935033175 0.950126768674963 -0.145520472520435 "KDR MUT" "DMOG_IC_50" 0.761195577240562 0.93574319967042 -0.314864939550949 0.600343243438921 0.949556813787471 0.488325723850373 0.775118423257931 0.972154599202611 -0.282082530366834 "EWS_FLI1 MUT" "Nilotinib_IC_50" 0.557581351952326 0.86900908342163 -0.260222504576982 0.600522234719801 0.949556813787471 -0.205568941336896 0.0585579062912341 0.70215997387469 0.870001685346224 "KDM6A MUT" "PD.0332991_IC_50" 0.268636815434096 0.732006752858616 -0.523355235252313 0.60062081792799 0.949556813787471 -0.199885200888117 0.355268655719578 0.91161229252998 -0.422732576033118 "EGFR MUT" "AG.014699_IC_50" 0.54373918890478 0.862633715268747 0.199702829439253 0.600647179272305 0.949556813787471 0.152803079433359 0.900268389029732 0.988704788932507 0.0404706946672164 "NOTCH1 MUT" "LFM.A13_IC_50" 0.915686869239708 0.98476490303336 -0.0296864750445634 0.600667484482463 0.949556813787471 -0.142137964415006 0.76030414399369 0.969901216545994 -0.0939023539696504 "FGFR2 MUT" "Vinblastine_IC_50" 0.313147361576581 0.759215564942334 1.27596995825427 0.600705179205585 0.949556813787471 0.481998992771439 0.713351925959315 0.962630898212352 0.615587952437324 "STK11 MUT" "PF.562271_IC_50" 0.846895087562419 0.961922915032848 0.0617759018817214 0.600748306374497 0.949556813787471 -0.136781495061041 0.81884070166969 0.977383317127464 0.0765788793224755 "MSH2 MUT" "ABT.888_IC_50" 0.438794863291532 0.824054351147029 -0.311373768681316 0.600780884971654 0.949556813787471 0.177661266237534 0.657244288740967 0.958313128388245 0.168142403454045 "BRAF MUT" "OSI.906_IC_50" 0.416220098186307 0.814099702076568 -0.234856887843956 0.600783665879045 0.949556813787471 0.156314027347976 0.317059700225274 0.900918773778407 -0.347311723386984 "FBXW7 MUT" "Midostaurin_IC_50" 0.697514749029632 0.9148149981614 0.157839746428569 0.601318683782011 0.949989154870657 0.164217489467763 0.684616097907577 0.961100601384891 0.15590971039656 "NRAS MUT" "Methotrexate_IC_50" 0.264255182423998 0.726560302215652 -0.451620650586358 0.601894078307521 0.949989154870657 -0.167212264321376 0.860923353138894 0.985524480087535 0.0644947054629813 "APC MUT" "BIRB.0796_IC_50" 0.129232568099642 0.590691938905261 0.341160282258068 0.601908918480822 0.949989154870657 0.116616860753158 0.3524770621051 0.91110953125066 0.254262084608614 "CTNNB1 MUT" "CCT007093_IC_50" 0.317936544346467 0.761258739353268 0.295524657534244 0.60194684495558 0.949989154870657 0.155733327650388 0.650387324405699 0.957867556929346 0.150496715885514 "MYC MUT" "Nutlin.3a_IC_50" 0.226766844079943 0.699276507734018 0.371086991561179 0.602127468114715 0.949989154870657 0.14715657889374 0.497709525244433 0.934042323734638 0.210997228612408 "MYCN MUT" "CCT018159_IC_50" 0.44212018065343 0.825166478070376 0.276806132075472 0.602144486735731 0.949989154870657 0.182239739467073 0.536255469249309 0.943443271455699 0.283348851026972 "JAK2 MUT" "Pazopanib_IC_50" 0.32385164258593 0.765538045729476 0.706617235839611 0.602165429998284 0.949989154870657 0.317571337459245 0.704089735266762 0.962447427875037 0.27030817194434 "TP53 MUT" "MG.132_IC_50" 0.551669428298123 0.865580796066258 0.170997860626488 0.602192886601327 0.949989154870657 0.138564338161929 0.943371318718512 0.995314665488626 -0.0207021276881208 "PIK3R1 MUT" "X17.AAG_IC_50" 0.687091080288596 0.911748124009352 0.314959381021193 0.602214489784024 0.949989154870657 -0.358559436639547 0.620515937417588 0.950496524771391 0.338566179524934 "MLLT3 MUT" "Erlotinib_IC_50" 0.629910369117738 0.892582202029064 0.280746608623548 0.602653335225543 0.949989154870657 0.273788610721357 0.700724811474762 0.961100601384891 0.232070711910558 "EZH2 MUT" "AZ628_IC_50" 0.273566698255701 0.734000646544246 1.48573414726028 0.602871836536326 0.949989154870657 0.524837566621356 0.179533978585024 0.848722027112292 1.80181258435645 "CDKN2A MUT" "Embelin_IC_50" 0.0417536646865565 0.36823663960408 -0.244798264507421 0.602940131193875 0.949989154870657 0.0526101009779563 0.326297384912499 0.901495873281184 0.133803566165267 "RUNX1 MUT" "RDEA119_IC_50" 0.717685407402996 0.92132587844031 0.489698428571421 0.602946912721658 0.949989154870657 0.634717666839526 0.515967185883224 0.939635632721979 0.746072784809307 "CDKN2C MUT" "EHT.1864_IC_50" 0.568524939320903 0.872389778906173 0.296378153153152 0.602979242702458 0.949989154870657 0.27176022473667 0.716945727686394 0.963986227227103 0.202127501952813 "NF1 MUT" "A.770041_IC_50" 0.179331263690888 0.658614416960816 1.01039044035088 0.603213775009408 0.949989154870657 0.321533365433357 0.255849753979177 0.875707386589409 0.937830313963738 "IDH1 MUT" "EHT.1864_IC_50" 0.527199610715693 0.855121165130409 -0.566641964285714 0.603253206321035 0.949989154870657 -0.459471868098168 0.590306474852654 0.949294892873838 -0.472456298827019 "EP300 MUT" "CMK_IC_50" 0.714920467115496 0.920308547391321 -0.442576517006803 0.603528691531422 0.949989154870657 0.57510950334989 0.993323104027625 0.999469155159075 0.0103876097192187 "FLCN MUT" "GSK269962A_IC_50" 0.398999172253324 0.805918367644724 1.13078210884354 0.603545726287486 0.949989154870657 0.649682068877415 0.785844160807688 0.974807190013589 0.640533899875693 "CDK6 MUT" "Bryostatin.1_IC_50" 0.406000392099558 0.808450556555196 0.372849372803164 0.60359672810736 0.949989154870657 0.219749214701178 0.291244631275493 0.891022884087089 0.483730407657645 "ERBB2 MUT" "Sunitinib_IC_50" 0.352335264374984 0.784969887597353 1.27144849943117 0.603617300587476 0.949989154870657 0.536262154415412 0.551235578687231 0.947060194029534 0.731104009101764 "NOTCH1 MUT" "GW.441756_IC_50" 0.492166374322261 0.842990705166559 0.226260942302362 0.603773723144139 0.949989154870657 0.173793876319502 0.603172627852995 0.949657634568742 0.184522447892493 "VHL MUT" "EHT.1864_IC_50" 0.514654620595927 0.851706582334351 -0.293949321266969 0.60384850770399 0.949989154870657 -0.233901262136349 0.205155713034663 0.853446327418758 -0.601164686763424 "ERBB2 MUT" "NSC.87877_IC_50" 0.49712753378836 0.844812404817149 0.187074971369077 0.604054836067154 0.949989154870657 0.144441829685119 0.280687803519113 0.887745150659987 0.319758251442551 "RUNX1 MUT" "BMS.754807_IC_50" 0.588018032940432 0.876506729771444 0.560081607692312 0.604059138350217 0.949989154870657 0.446844012695174 0.901612390517971 0.988746233284632 -0.139287382690637 "MET MUT" "WZ.1.84_IC_50" 0.776619362154165 0.941591338606299 -0.337272721088437 0.604117861215376 0.949989154870657 -0.510285363541521 0.89676548408808 0.988301482344111 0.146676627292614 "ALK MUT" "Sorafenib_IC_50" 0.830079024054695 0.958015830101332 0.230401023809525 0.604215721343469 0.949989154870657 0.531594380413693 0.828158543986665 0.981081757090089 -0.294771237551295 "FBXW7 MUT" "OSI.906_IC_50" 0.96664921697221 0.994434372972651 0.018526377395577 0.604280364176982 0.949989154870657 0.217868760679013 0.684330392340296 0.961100601384891 0.188222182414112 "MLH1 MUT" "MS.275_IC_50" 0.61360803996429 0.885370106080074 0.396953569686413 0.60443347230214 0.949989154870657 -0.341465499690262 0.385665992466353 0.915331032347709 0.717966692326201 "BRCA2 MUT" "AZD8055_IC_50" 0.07425472282439 0.479604504293387 1.27003945924456 0.604493492872962 0.949989154870657 0.288670779603167 0.333506557205808 0.903569160603576 0.669215963748143 "MYC MUT" "AZD.0530_IC_50" 0.263038912421593 0.725255691156837 0.48117993848485 0.604620129079828 0.949989154870657 0.19773599266969 0.780448405076589 0.972658193304124 0.119814671656928 "CCND1 MUT" "BMS.536924_IC_50" 0.560219318723152 0.869809050625929 0.42419876140351 0.604626292209707 0.949989154870657 0.284280433312683 0.220553399929857 0.864474168037968 0.98221391182575 "NRAS MUT" "LFM.A13_IC_50" 0.49446046971577 0.843282996121548 0.121063876279483 0.604670234765318 0.949989154870657 0.0888764218864968 0.379425655777719 0.915134825237766 0.177228689600549 "BRAF MUT" "XMD8.85_IC_50" 0.703322950328685 0.915500829364901 0.164458386602871 0.604711847479053 0.949989154870657 0.198361892485853 0.473764163208923 0.929505752020906 0.390821501888361 "MYC MUT" "KU.55933_IC_50" 0.55076883986947 0.865580796066258 0.12626139233434 0.604874898289669 0.949989154870657 0.0976127617584276 0.248606530549539 0.875707386589409 0.252539369145432 "FGFR2 MUT" "AZD.2281_IC_50" 0.852659941476498 0.964196154467744 0.197037017716532 0.604883040362932 0.949989154870657 -0.417633836388238 0.247253421117312 0.875707386589409 1.52145064155384 "EP300 MUT" "WO2009093972_IC_50" 0.622919244472162 0.889412509671587 -0.439090355658202 0.605135061148347 0.949989154870657 -0.416068720635712 0.90110598362044 0.988746233284632 -0.108779326358862 "AKT2 MUT" "AZ628_IC_50" 0.787888995453191 0.946449577332088 0.515061806122449 0.605185251426946 0.949989154870657 0.731304167888272 0.7349807303493 0.96672489654949 0.561949513289771 "FGFR3 MUT" "Elesclomol_IC_50" 0.526204163908135 0.854969048950887 -0.977880343453504 0.605381615140775 0.949989154870657 -0.662032481820561 0.642682802041845 0.955897833685082 -0.674273186848255 "MLLT3 MUT" "BIRB.0796_IC_50" 0.657909624268845 0.901751651084414 0.129123466492033 0.605552005579213 0.949989154870657 0.144096529698314 0.668417050345112 0.959230524020512 0.129907335824091 "MLLT3 MUT" "CGP.60474_IC_50" 0.854182190379752 0.964541653680809 -0.109971756643356 0.605556139886447 0.949989154870657 -0.228692579218291 0.545518817156312 0.946853280734584 -0.371493410460514 "CCND2 MUT" "LFM.A13_IC_50" 0.718978864017061 0.92132587844031 -0.230348432055747 0.605564106469753 0.949989154870657 -0.309102500763161 0.619185144613042 0.950394619652337 -0.386981253708613 "FGFR2 MUT" "FH535_IC_50" 0.0203319934478319 0.258938579544408 1.84646890401398 0.605745616127109 0.949989154870657 0.358571857257357 0.151758818811993 0.832065593775825 1.26063852034408 "APC MUT" "Embelin_IC_50" 0.661345688573324 0.902490943487968 -0.115782323644096 0.605791518078939 0.949989154870657 -0.113496627226332 0.275025537145315 0.883780956691668 -0.347269958764707 "NOTCH1 MUT" "EHT.1864_IC_50" 0.517976692404794 0.852353345422823 0.41057600896862 0.60617725052331 0.949989154870657 0.324058326270015 0.570025180706929 0.949294892873838 0.347929063494861 "CDKN2a(p14) MUT" "PD.173074_IC_50" 0.961934220014979 0.994012653885573 -0.0062375852295475 0.606188319811309 0.949989154870657 0.0599509247507606 0.995219135957548 0.999545005862799 -0.000805354256736252 "MDM2 MUT" "Roscovitine_IC_50" 0.299809710847471 0.751119785777076 -0.781532125435539 0.606324108352062 0.949989154870657 -0.342858118790487 0.500932849596547 0.934042323734638 -0.508000717968444 "FGFR2 MUT" "NSC.87877_IC_50" 0.166477931567903 0.645911101028637 0.776482525951552 0.606370681622319 0.949989154870657 0.289059957340473 0.111264148018713 0.797376436030023 1.04526401465835 "BRCA2 MUT" "BX.795_IC_50" 0.0440991292361078 0.376006653842012 1.61127090243905 0.606422850436769 0.949989154870657 0.320084542195668 0.451944174882494 0.925809648901546 0.533568132196352 "BCR_ABL MUT" "GSK269962A_IC_50" 0.804272160548609 0.952365474377626 -0.288396561433445 0.606531195437956 0.949989154870657 0.710247250984295 0.819506899079922 0.977383317127464 -0.268907233803166 "ERBB2 MUT" "Bicalutamide_IC_50" 0.34140613957981 0.778707276763076 -0.145239542016807 0.606545869979206 0.949989154870657 -0.0769827273445185 0.837647003546472 0.981704379975756 -0.0310972643092835 "KIT MUT" "BX.795_IC_50" 0.130685067818936 0.59349449267004 -1.21077326829269 0.606629778604781 0.949989154870657 -0.319672439464114 0.221716016917548 0.865076203633533 -0.869932965314296 "CDKN2C MUT" "AZD6244_IC_50" 0.903718436870766 0.979846592339064 -0.0966125855949899 0.606697543004489 0.949989154870657 -0.375492685051247 0.608969848225866 0.949930222127033 0.391446675953482 "EZH2 MUT" "CHIR.99021_IC_50" 0.378905361955044 0.795952477739693 0.479912176397526 0.606907318822081 0.949989154870657 0.264818131167172 0.919429503787192 0.993794649720217 0.0573648443147728 "ALK MUT" "Imatinib_IC_50" 0.635737635534895 0.894862632072096 0.331570033898306 0.607000144363787 0.949989154870657 0.35889514273861 0.881959073509194 0.988301482344111 0.12841767181487 "MET MUT" "Tipifarnib_IC_50" 0.22662833237948 0.699276507734018 -0.823500257629302 0.607290602677104 0.949989154870657 -0.23369591351366 0.25207662369726 0.875707386589409 -0.769280273602871 "SMAD4 MUT" "AP.24534_IC_50" 0.0757747471352815 0.481370192638366 0.935070162125093 0.607322069261547 0.949989154870657 0.251503076489456 0.193671986123006 0.851001889249827 0.691688044654872 "ERBB2 MUT" "BMS.708163_IC_50" 0.693496429191822 0.913368820021033 0.121768111751152 0.60741242992766 0.949989154870657 0.166325761009485 0.980914236440186 0.99788079425261 -0.00797673724814738 "EWS_FLI1 MUT" "Lapatinib_IC_50" 0.578098350053695 0.873750949722175 0.30441864445163 0.607852571834014 0.949989154870657 -0.263576338075189 0.677132923442397 0.960488339417334 0.230339868144886 "ERBB2 MUT" "Lenalidomide_IC_50" 0.984058042132472 0.996723172778267 -0.00522921070772089 0.607860831740676 0.949989154870657 -0.121798121264875 0.493926450655611 0.933639405738697 -0.183044671813584 "MLL_AFF1 MUT" "X681640_IC_50" 0.23063141608414 0.70328674741747 -1.384238474645 0.607946441347695 0.949989154870657 0.515030889758715 0.838099391531426 0.981704379975756 0.224526523960916 "MYCN MUT" "Etoposide_IC_50" 0.940147448459389 0.989446598697723 0.0428958493035429 0.607986373918215 0.949989154870657 -0.195105352200172 0.137817825899163 0.831473272394224 -0.92625228221392 "EZH2 MUT" "MG.132_IC_50" 0.633694160992607 0.89399270048764 0.56707173469388 0.608054298724795 0.949989154870657 -0.537776972330226 0.684766126728402 0.961100601384891 -0.515275970025909 "MDM2 MUT" "CGP.60474_IC_50" 0.42682387939978 0.81941696345643 -0.666302199312717 0.608165486673789 0.949989154870657 -0.319971439205704 0.728246785484879 0.965402608571648 -0.284152207213037 "EWS_FLI1 MUT" "MK.2206_IC_50" 0.183262644739488 0.660385845878234 -0.643759965569311 0.608200113621361 0.949989154870657 0.211956226366118 0.866988883162992 0.987077901072027 0.0922602316671187 "KDM6A MUT" "AP.24534_IC_50" 0.385247090782251 0.798746759187088 -0.533995284441052 0.608241488708404 0.949989154870657 -0.284609910111598 0.281467499052061 0.887872038823822 -0.659463036683444 "MSH2 MUT" "AG.014699_IC_50" 0.678046141568983 0.908720747099578 0.299794259009011 0.608266712023779 0.949989154870657 0.327149924378012 0.786676825982901 0.975087420732438 -0.181136238061968 "BRCA1 MUT" "AG.014699_IC_50" 0.837704323683837 0.959212493377535 0.147933105855859 0.608309294606241 0.949989154870657 -0.326844265443808 0.924002852600968 0.993978204254811 0.0635629005183293 "BRCA2 MUT" "A.770041_IC_50" 0.146295269312091 0.619919550890177 2.63108516271184 0.608529706268677 0.949989154870657 0.762228104271131 0.159338898672162 0.838901067822678 2.45380085937721 "EP300 MUT" "Doxorubicin_IC_50" 0.31861894081026 0.761267128904167 -1.12525795528454 0.608665065440633 0.949989154870657 -0.361646551260899 0.289029984123831 0.889281028047524 -1.13244840976812 "KIT MUT" "Vinorelbine_IC_50" 0.24545965942178 0.714359708232298 -1.05567311438474 0.608842312092921 0.949989154870657 -0.343617665982544 0.278493530328767 0.885713545160236 -0.969679348034368 "AKT2 MUT" "AZD8055_IC_50" 0.346861011539922 0.782020929432191 0.599915752988042 0.60908327163181 0.949989154870657 0.253718169742773 0.346383068393718 0.909317472748763 0.586407364951599 "EWS_FLI1 MUT" "Vinorelbine_IC_50" 0.114068979036997 0.566018083713894 -0.836089797178122 0.609187078435728 0.949989154870657 -0.211461606537051 0.946930584717459 0.995668765770473 0.0395204506860733 "EWS_FLI1 MUT" "GW843682X_IC_50" 0.101876112232347 0.542024654294532 1.22296844405596 0.609327497914941 0.949989154870657 0.214761919094134 0.363124629356613 0.912280009424634 0.812472223180999 "CCND2 MUT" "QS11_IC_50" 0.91431278059061 0.984363171829944 -0.122151069105691 0.609341821271341 0.949989154870657 -0.423786103373243 0.996871981868625 0.999545005862799 -0.00530687549455177 "EWS_FLI1 MUT" "CMK_IC_50" 0.310429210419371 0.757046299071613 0.531870221371602 0.609383833942212 0.949989154870657 0.260355438152313 0.597073685022157 0.949294892873838 0.327147703362458 "MS-HL MUT" "Axitinib_IC_50" 0.84036618361254 0.959424448728358 0.0480834726139383 0.609577361851333 0.949989154870657 0.103218023875799 0.493111784377972 0.933639405738697 0.157064236540562 "EP300 MUT" "CI.1040_IC_50" 0.582815239013705 0.876506729771444 -0.56862743977056 0.609617048949571 0.949989154870657 -0.474913457778311 0.393440647870739 0.915926348152589 -0.774232071127158 "SETD2 MUT" "NSC.87877_IC_50" 0.531395144987206 0.856967547236495 0.496201034482769 0.609743912353659 0.949989154870657 0.400304203687337 0.394327323393894 0.915926348152589 0.685745710590484 "KIT MUT" "Dasatinib_IC_50" 0.0660004208698653 0.458177989025628 -5.08543132653063 0.609777552969593 0.949989154870657 -1.21504104026469 0.592429194697339 0.949294892873838 -1.30323730007458 "ALK MUT" "GDC0941_IC_50" 0.670588084955279 0.906916702390321 -0.447354467078184 0.609832880583096 0.949989154870657 0.433506930238581 0.450478441646372 0.925809648901546 -0.971070512667632 "VHL MUT" "AZD7762_IC_50" 0.773473087401605 0.94153218611416 -0.183281749277457 0.609943690037149 0.949989154870657 -0.255168994606564 0.989464816606858 0.998596878102629 0.00829816726755566 "CDKN2C MUT" "PD.0325901_IC_50" 0.626532264018795 0.89123540333742 0.38957154559118 0.610001192155949 0.949989154870657 0.385507719708662 0.381887899483002 0.915134825237766 0.656559193149623 "NOTCH1 MUT" "KIN001.135_IC_50" 0.136241020738765 0.603770711168148 0.355068529040406 0.610108588497691 0.949989154870657 0.12479843349271 0.276570670257322 0.884207634152307 0.280833021270379 "KDM5C MUT" "Z.LLNle.CHO_IC_50" 0.960020187160198 0.993583414773304 -0.0458152294520546 0.610182095071308 0.949989154870657 -0.430118713078771 0.893059726061844 0.988301482344111 0.119188372997088 "PIK3CA MUT" "Bicalutamide_IC_50" 0.243389544339744 0.712594714273313 -0.103375213511791 0.610252276106348 0.949989154870657 -0.0434558467742766 0.602793385273152 0.949657634568742 -0.0474503903551113 "ALK MUT" "CGP.60474_IC_50" 0.36011840170802 0.786601117838604 0.85629394520548 0.610256517119367 0.949989154870657 0.356092916615068 0.303815208914029 0.894622967627816 1.0951502572583 "SMAD4 MUT" "JNK.9L_IC_50" 0.837464575197259 0.959212493377535 0.0536746821101201 0.610621458969461 0.950034460502657 0.107384470310519 0.575299840497237 0.949294892873838 0.15616414614376 "PIK3CA MUT" "MG.132_IC_50" 0.46810104435019 0.831367686108334 -0.48632269365722 0.610651019401495 0.950034460502657 -0.301972273402163 0.367656538738396 0.913948248824328 -0.61507350270572 "EWS_FLI1 MUT" "Lenalidomide_IC_50" 0.947676400712318 0.990899019819731 0.0188697364771153 0.610702232484188 0.950034460502657 0.137995306468945 0.376327158817341 0.914419412871569 0.281430251271824 "JAK2 MUT" "Bortezomib_IC_50" 0.771551136523049 0.94006662689823 -0.379351860068252 0.6108446970927 0.950034460502657 -0.535542446277492 0.73963337194306 0.96672489654949 0.509922973730762 "CDKN2C MUT" "S.Trityl.L.cysteine_IC_50" 0.533297957120032 0.858279561609675 -0.53602065402299 0.610846681750743 0.950034460502657 -0.239572401383781 0.827123837946676 0.980722158759675 -0.232411912647961 "FAM123B MUT" "Epothilone.B_IC_50" 0.70693813140659 0.917078227435279 0.394163223776228 0.611066797436013 0.950034460502657 -0.302965417007661 0.697013645863168 0.961100601384891 0.403731584672337 "CCND2 MUT" "AZD6482_IC_50" 0.686382490937089 0.911730003936733 -0.459542706390325 0.611067118201386 0.950034460502657 -0.485545210627646 0.977073782018397 0.99742775226181 0.0390348199473837 "FBXW7 MUT" "JW.7.52.1_IC_50" 0.187807960342103 0.663245512002727 -1.13813373519165 0.611141411198252 0.950034460502657 0.272673631123547 0.201419431505814 0.851001889249827 -1.15941507783052 "AKT2 MUT" "MK.2206_IC_50" 0.984410117563706 0.996723172778267 -0.0156831078838172 0.611260904604604 0.950053919109817 -0.325031471021175 0.928810100946118 0.994186152404781 0.0706345168775386 "KRAS MUT" "Salubrinal_IC_50" 0.317439308425235 0.761258739353268 -0.380772777222778 0.611417946630222 0.950087154976843 -0.171637424924491 0.580608386791388 0.949294892873838 -0.230643616214562 "ERBB2 MUT" "Vinorelbine_IC_50" 0.542041216959868 0.86219233735578 0.303860237896926 0.611496247927895 0.950087154976843 -0.190879373914771 0.874447343382501 0.98777404048288 0.0820808602839429 "FLT3 MUT" "CEP.701_IC_50" 0.754999223188443 0.934254995281673 0.333616447401767 0.612001725700857 0.950472343468257 -0.400689647932177 0.22804890532698 0.867738786721896 1.17305107123125 "APC MUT" "Shikonin_IC_50" 0.277235901828768 0.735258595314258 0.403982743636365 0.612014485769827 0.950472343468257 0.165980818032539 0.640529871385394 0.955094994589269 -0.206909591604272 "MLL_AFF1 MUT" "XMD8.85_IC_50" 0.117994239294856 0.574825474041481 -2.01522626712328 0.612207283132916 0.950472343468257 -0.572887763864712 0.23526691254288 0.869962136993019 -1.51186385961292 "SMAD4 MUT" "CCT007093_IC_50" 0.774775007447345 0.941591338606299 -0.0584933055152399 0.612208898329491 0.950472343468257 -0.107597007180599 0.414397164857172 0.92211126027385 -0.179214822765017 "KRAS MUT" "Sunitinib_IC_50" 0.980094168915103 0.996332002460735 0.012771379359771 0.612452801229907 0.950472343468257 0.203597332763118 0.602801680572399 0.949657634568742 -0.255204898846795 "CCND2 MUT" "Bleomycin_IC_50" 0.906319949202855 0.981251818741413 -0.224680075493609 0.612462333626392 0.950472343468257 -0.784156178449229 0.591031185225788 0.949294892873838 -1.20745286043956 "FBXW7 MUT" "PLX4720_IC_50" 0.525309054020932 0.854969048950887 -0.255987578035685 0.612556354669981 0.950472343468257 0.18182892233561 0.390431757703522 0.915926348152589 -0.333406779322512 "MYC MUT" "ABT.263_IC_50" 0.588502330800324 0.876506729771444 -0.193767467510548 0.612829126366527 0.950472343468257 -0.163596308429135 0.684810110747513 0.961100601384891 -0.132052329304331 "HRAS MUT" "Vorinostat_IC_50" 0.935048807627234 0.98800338614366 -0.0423634682539679 0.61285263665377 0.950472343468257 0.201310639959832 0.420612496321821 0.922428741067589 -0.381415394405348 "BCR_ABL MUT" "GSK.650394_IC_50" 0.368236659057851 0.789246419666677 -0.939226870855167 0.612901606065084 0.950472343468257 -0.412976946833979 0.591567533189251 0.949294892873838 -0.56869612868876 "MYCN MUT" "GW843682X_IC_50" 0.159526910172157 0.636336191287136 0.775248149585923 0.612921417750558 0.950472343468257 0.148025819222339 0.969206440602198 0.997173634484198 -0.0266254599160144 "FBXW7 MUT" "EHT.1864_IC_50" 0.393404787166125 0.803073858340542 0.292984370904322 0.613126594429612 0.950621671427169 0.172386590336475 0.459791528629448 0.927836529370171 0.258364256044767 "ERBB2 MUT" "Sorafenib_IC_50" 0.735320812428701 0.928872455997232 0.314838996587032 0.613406455320691 0.950621671427169 -0.456946055940841 0.509509032405268 0.938202304953595 0.657774728598187 "NF2 MUT" "BMS.708163_IC_50" 0.398465383830345 0.805914614847938 0.228966853479853 0.613507055053846 0.950621671427169 0.139382259404303 0.539207075558492 0.944569766818715 0.179188326413746 "TSC1 MUT" "PLX4720_IC_50" 0.557785935379707 0.86900908342163 -0.784835778202679 0.61368157429189 0.950621671427169 -0.601688853944243 0.47348017531867 0.929276781658587 -0.869119203141613 "JAK2 MUT" "Sorafenib_IC_50" 0.394316651290112 0.803222955584382 0.914006125850347 0.613813046824899 0.950621671427169 0.510179857912826 0.4452432207232 0.925809648901546 1.0422208979753 "IDH1 MUT" "GDC0941_IC_50" 0.919792457589354 0.98596389099784 0.12958671252567 0.614055524084396 0.950621671427169 0.518936280131849 0.811418642063559 0.977383317127464 0.306970884486459 "MYCN MUT" "A.770041_IC_50" 0.192504967463677 0.668037820564704 0.753307795548656 0.614083013329261 0.950621671427169 -0.248123611784011 0.253039847660944 0.875707386589409 -0.75665093800555 "EZH2 MUT" "TW.37_IC_50" 0.758852944097741 0.934762260113025 -0.208043914414416 0.614298762540927 0.950621671427169 -0.307266888812889 0.307676223985972 0.89718581932126 -0.66110470658223 "MS-HL MUT" "Epothilone.B_IC_50" 0.1037938743885 0.546119906272292 -0.486620942656628 0.614406223351437 0.950621671427169 0.0870403509465531 0.0800788058786435 0.741811190933953 -0.568734110461682 "BRCA1 MUT" "LFM.A13_IC_50" 0.518281337138014 0.852380843541241 -0.358410427574177 0.61459675519204 0.950621671427169 -0.263283383378046 0.627881424066792 0.952146453272921 -0.26974984563387 "FGFR2 MUT" "GDC.0449_IC_50" 0.984598331750124 0.996723172778267 0.016712104247104 0.614867167116609 0.950621671427169 -0.390950499934493 0.683624100123038 0.961100601384891 0.493265465574169 "FGFR3 MUT" "Lapatinib_IC_50" 0.740003682663948 0.929570057037101 -0.419389896551725 0.615194440467162 0.950621671427169 0.546442035381986 0.711057145999308 0.962630898212352 0.411721410307445 "CDH1 MUT" "PF.562271_IC_50" 0.152391245864369 0.625830613280407 0.737236182082608 0.615283657451124 0.950621671427169 0.214107953305836 0.112262592534775 0.797376436030023 0.859863637856625 "NOTCH1 MUT" "BMS.754807_IC_50" 0.692702056205062 0.913066921534475 0.230652704768272 0.615306211995421 0.950621671427169 0.252938501236393 0.52167689302167 0.939635632721979 -0.404358843374996 "MSH2 MUT" "FH535_IC_50" 0.43330189039151 0.822749994507661 -0.47360218070176 0.615805608830291 0.950621671427169 -0.26211918545732 0.154098190179363 0.835611501078903 -0.832044629627296 "TSC1 MUT" "PAC.1_IC_50" 0.83060642986717 0.958375432460743 0.261553641739133 0.616010609179192 0.950621671427169 0.513090849824717 0.489941623186871 0.933639405738697 0.811463694423714 "BCR_ABL MUT" "RO.3306_IC_50" 0.801856036091074 0.950899112902234 0.185140666666667 0.61626537636798 0.950621671427169 0.431459283046695 0.627403735998183 0.952105511848497 0.369293971337124 "CTNNB1 MUT" "MK.2206_IC_50" 0.742701666332627 0.929570057037101 0.178742487012986 0.616442078135883 0.950621671427169 -0.218045591989263 0.840122562435542 0.981985848511457 -0.118959521085573 "BCR_ABL MUT" "Erlotinib_IC_50" 0.0764111796889643 0.483683312058227 -1.5302672893773 0.616497456933162 0.950621671427169 0.508306672295399 0.0376142774607907 0.645472009508728 -1.78429346870759 "KIT MUT" "MK.2206_IC_50" 0.638063691411052 0.895624997957207 -0.42163017184265 0.616554953306973 0.950621671427169 -0.359426284369258 0.624039323836429 0.950496524771391 -0.432384141264433 "MDM2 MUT" "FH535_IC_50" 0.79971583963881 0.950264432945179 -0.128673619047619 0.616647355413839 0.950621671427169 -0.217291091259444 0.875104847485565 0.98777404048288 0.0760688078740773 "NF1 MUT" "BMS.708163_IC_50" 0.66327530687621 0.903526384925934 0.110861615023475 0.616729133680606 0.950621671427169 0.129001248384279 0.651454625631949 0.958313128388245 0.124077167531999 "MSH6 MUT" "Bicalutamide_IC_50" 0.73913884522576 0.929570057037101 -0.0735410500878735 0.617089312302738 0.950621671427169 -0.104918945504815 0.527721597570707 0.942617761067065 -0.129865347608399 "VHL MUT" "Vorinostat_IC_50" 0.393576003119816 0.803073858340542 0.384706199203188 0.617198665930577 0.950621671427169 0.172967059115936 0.606550317002046 0.949657634568742 0.22972760894663 "MYCL1 MUT" "GDC.0449_IC_50" 0.779387448280459 0.942683810925913 -0.130248373712057 0.617449031314141 0.950621671427169 -0.205945608320106 0.982853440530883 0.998011368051263 -0.0108971802814314 "CDK4 MUT" "Bortezomib_IC_50" 0.172575843631368 0.650961807890931 -2.17560712585034 0.617876450208851 0.950621671427169 -0.653877365460566 0.590940369183402 0.949294892873838 -0.821470377023536 "FGFR3 MUT" "NU.7441_IC_50" 0.787780104615355 0.946449577332088 0.272866220907306 0.617899497406349 0.950621671427169 0.443776817601596 0.849433076323529 0.984337428855677 -0.184766377578745 "JAK2 MUT" "AZD6482_IC_50" 0.95440628724516 0.992679871625456 -0.0427504916770201 0.617964128768023 0.950621671427169 -0.314738148727087 0.955834704176145 0.996100446818628 0.0439865658195413 "PTEN MUT" "VX.702_IC_50" 0.883321373838474 0.973927829424842 -0.0274254116777532 0.617998723597693 0.950621671427169 -0.0780550504709666 0.982779983567645 0.998011368051263 0.00407405203678888 "RUNX1 MUT" "Mitomycin.C_IC_50" 0.575057068445936 0.872620551543038 -0.557933527272731 0.618095223588158 0.950621671427169 -0.387727109883124 0.171822680637976 0.842832361237713 -1.46754203494357 "NRAS MUT" "Vinblastine_IC_50" 0.615874165847578 0.885815598771911 -0.150903551077286 0.618100322468404 0.950621671427169 0.113074170455676 0.875500551995946 0.987838063957761 0.0502982961426843 "SMARCA4 MUT" "FTI.277_IC_50" 0.571262742723347 0.872389778906173 -0.19898491958042 0.618202323351263 0.950621671427169 -0.159001024297914 0.461333077017039 0.929276781658587 -0.280928804119149 "BRAF MUT" "X17.AAG_IC_50" 0.0185745632639798 0.248885968328711 -0.734212501964551 0.618467183102621 0.950621671427169 -0.15025519905447 0.467078787294519 0.929276781658587 0.238097545852954 "FBXW7 MUT" "SL.0101.1_IC_50" 0.116645074283398 0.571973892266404 -0.406733530434779 0.618681472153279 0.950621671427169 -0.112874767051513 0.341903571227912 0.907180409180092 -0.251909622290907 "JAK2 MUT" "PHA.665752_IC_50" 0.539888485518231 0.861547651912703 0.487277205387199 0.618690983525638 0.950621671427169 0.392070428689906 0.516337242562836 0.939635632721979 0.651690301026925 "MDM2 MUT" "AKT.inhibitor.VIII_IC_50" 0.429821488480027 0.820918238409269 0.40317200874126 0.618746045694378 0.950621671427169 0.217806093506119 0.289197528723115 0.88932245588296 0.526883047254612 "CCND2 MUT" "NSC.87877_IC_50" 0.630591594209886 0.893044801176527 0.311585319516406 0.618906791138847 0.950621671427169 0.31483585637808 0.269833862939986 0.878819138279722 0.886094089749509 "CCND1 MUT" "PF.4708671_IC_50" 0.993641130364537 0.998970779334534 -0.00189224389354716 0.618982406381366 0.950621671427169 0.11803311106752 0.794175258371459 0.975393509832241 -0.0679327084031389 "PIK3CA MUT" "BIRB.0796_IC_50" 0.0952582755287621 0.528067151268111 0.301150436058704 0.619099797858439 0.950621671427169 0.0867193514398839 0.0781347376088257 0.741811190933953 0.347691577135965 "KDM5C MUT" "AG.014699_IC_50" 0.735685318057082 0.928872455997232 -0.281190447191014 0.619249597926268 0.950621671427169 0.365903439895165 0.70907501589882 0.962630898212352 -0.286790655824681 "CDKN2C MUT" "BX.795_IC_50" 0.637219981068673 0.895293569351508 -0.268507737704919 0.619510092353602 0.950621671427169 -0.219254318451292 0.492902345336461 0.933639405738697 0.368432435072476 "VHL MUT" "Embelin_IC_50" 0.90716608777539 0.981251818741413 -0.0594391212653778 0.619545861706199 0.950621671427169 0.203520940065451 0.741076797306571 0.96672489654949 0.180571756987917 "EP300 MUT" "Tipifarnib_IC_50" 0.810048183041429 0.952739326074327 0.311478221835072 0.619651593140284 0.950621671427169 0.429560805618193 0.787874578803034 0.975265472692061 0.341267840407276 "CDK4 MUT" "Lenalidomide_IC_50" 0.660624214080837 0.902400992643984 0.148784335260116 0.619917293069885 0.950621671427169 -0.147798576191629 0.946574261374639 0.995668765770473 -0.0228245322767404 "BRCA1 MUT" "Etoposide_IC_50" 0.272386306084367 0.734000646544246 1.20680151681109 0.619990103596286 0.950621671427169 -0.354897178425452 0.376297417661587 0.914419412871569 0.924103797382058 "ALK MUT" "Nilotinib_IC_50" 0.863704400760944 0.967405572349344 0.19925332637571 0.620027708211831 0.950621671427169 0.471657580678471 0.88439263596823 0.988301482344111 0.152722250616327 "SMO MUT" "Lenalidomide_IC_50" 0.616290731323053 0.885815598771911 0.376816413662238 0.620127263370479 0.950621671427169 0.325662578993084 0.676448754826868 0.960256725054738 0.299600335904473 "SMARCA4 MUT" "BI.D1870_IC_50" 0.367061719937065 0.788956157846227 0.463273402321084 0.62025553088872 0.950621671427169 0.218448977335193 0.569113575462982 0.949294892873838 0.316255542841226 "MDM2 MUT" "Axitinib_IC_50" 0.622201500201357 0.888816394287961 0.279725084778421 0.62031791845286 0.950621671427169 -0.237451524871796 0.614522700434509 0.950059945073224 0.249779167727318 "SETD2 MUT" "Pyrimethamine_IC_50" 0.121790204227561 0.580982694522287 2.54719732203389 0.620322010208021 0.950621671427169 0.699729018323895 0.204605627782665 0.853446327418758 2.11765720476559 "PTEN MUT" "GSK.650394_IC_50" 0.61251261156149 0.88496040166963 0.12380106049737 0.620632493115997 0.950621671427169 0.0799349380070318 0.67981270460966 0.961100601384891 -0.108750375693226 "MET MUT" "BI.D1870_IC_50" 0.0904009945705606 0.51530887855016 0.794678958899671 0.620687046425941 0.950621671427169 0.201121568439552 0.450827899476242 0.925809648901546 0.335596369948306 "EP300 MUT" "FH535_IC_50" 0.476305708766361 0.835487062918043 -0.655347258420435 0.620692815567988 0.950621671427169 -0.392079889678321 0.60631568924737 0.949657634568742 -0.451523014691428 "MLH1 MUT" "Lapatinib_IC_50" 0.119160460391443 0.577057450057752 0.993052042253527 0.620833486343113 0.950621671427169 0.27538855162227 0.34658705610343 0.909317472748763 0.534955326751799 "BRAF MUT" "Nilotinib_IC_50" 0.0668684944464268 0.459643265618201 -0.427027786536252 0.620852140385039 0.950621671427169 -0.103170407417646 0.0121656551002665 0.461723004040455 -0.62586882447128 "CDKN2C MUT" "Cisplatin_IC_50" 0.875896950636766 0.971594429690931 0.0922577936660279 0.620921599232932 0.950621671427169 0.252119470091706 0.533951704873126 0.943443271455699 0.376879782081872 "BCR_ABL MUT" "AZD.2281_IC_50" 0.0661394192017628 0.458177989025628 -1.37887538537547 0.621168773302247 0.950621671427169 0.342616594053507 0.755061873841994 0.969873373096723 0.212325758489069 "RB1 MUT" "GNF.2_IC_50" 0.952225934035012 0.992561499112566 0.0123902352238258 0.621218812980158 0.950621671427169 -0.102023726467284 0.349328965449787 0.909999728614578 -0.23047698123725 "HRAS MUT" "Elesclomol_IC_50" 0.0800097178152685 0.4914013166787 -1.56338204142765 0.62147669990622 0.950621671427169 -0.368055181433068 0.128822513689086 0.820169751013594 -1.28130268453479 "PIK3R1 MUT" "GW.441756_IC_50" 0.637042771447672 0.895268363706423 0.204448720729364 0.621484313271922 0.950621671427169 0.209099478569223 0.552003704791396 0.947060194029534 0.254646305783467 "CDK4 MUT" "Bicalutamide_IC_50" 0.354584297803283 0.785252181551816 -0.204380109841829 0.62161829880437 0.950621671427169 -0.10423012045444 0.795098179085496 0.975627957210581 0.0570451453071358 "MAP2K4 MUT" "Gemcitabine_IC_50" 0.948976882466363 0.991311220467028 -0.0727538319694465 0.621743436716125 0.950621671427169 -0.375825504750153 0.955756546076752 0.996100446818628 -0.0649494497196965 "EWS_FLI1 MUT" "KU.55933_IC_50" 0.288359965379685 0.743664502093737 -0.360964141414137 0.621829882640726 0.950621671427169 -0.159991506698074 0.689876420838511 0.961100601384891 -0.156281010298697 "MSH6 MUT" "GSK269962A_IC_50" 0.875320235205307 0.971594429690931 -0.18259918088737 0.621908728893812 0.950621671427169 -0.536665928353544 0.893891885502878 0.988301482344111 -0.153509064706256 "GNAS MUT" "Vinblastine_IC_50" 0.15048890721288 0.625010754600796 0.914207570537421 0.622110770455521 0.950621671427169 0.226298678541314 0.434234160777798 0.922569292988365 0.466349217164314 "AKT2 MUT" "Epothilone.B_IC_50" 0.300272593078498 0.751119785777076 -0.919048031578955 0.622273458773947 0.950621671427169 0.248833128953148 0.402934610691446 0.916850640727267 -0.732814661784262 "PIK3R1 MUT" "SL.0101.1_IC_50" 0.978129638670922 0.996276778834563 0.0118868689320394 0.622360349836172 0.950621671427169 -0.186124154332122 0.866840490255032 0.987077901072027 -0.0696053463609726 "MLLT3 MUT" "Midostaurin_IC_50" 0.293028972705432 0.747036827777118 -0.426832493344153 0.622560429129519 0.950621671427169 -0.153324002365433 0.432261157196268 0.922569292988365 -0.302137674789284 "CTNNB1 MUT" "AP.24534_IC_50" 0.385671835489743 0.798746759187088 -0.62791864550264 0.622633599237163 0.950621671427169 -0.321017641955314 0.676280961536871 0.960256725054738 -0.319265829388152 "PIK3CA MUT" "S.Trityl.L.cysteine_IC_50" 0.94519752693944 0.990147156460271 -0.0406875278608317 0.622712979893565 0.950621671427169 -0.159250229522485 0.996290466705477 0.999545005862799 0.00307082714183994 "KDR MUT" "Vinblastine_IC_50" 0.825730423136111 0.957177484110155 -0.227745688212926 0.622769324726935 0.950621671427169 0.368088991379181 0.913180959635063 0.99082410867764 -0.106956437810011 "MLH1 MUT" "MG.132_IC_50" 0.13711537166101 0.604353219297467 1.25740589655173 0.622867044319453 0.950621671427169 0.372252014815002 0.162577738985442 0.839927262232576 1.11405590725453 "MYCN MUT" "KIN001.135_IC_50" 0.540914627924055 0.861616652986104 0.107504796163069 0.622872953049169 0.950621671427169 0.0870488247604815 0.0466737026655188 0.673636396626734 0.387046205778797 "EGFR MUT" "PD.173074_IC_50" 0.378172266608183 0.795952477739693 0.276547616407983 0.622931043621244 0.950621671427169 0.131406075110597 0.580539289513457 0.949294892873838 0.167266078857954 "SMARCB1 MUT" "Mitomycin.C_IC_50" 0.937795695304778 0.98883650048509 0.122497653913046 0.622980938488855 0.950621671427169 0.602378878634148 0.743399589517682 0.966920292106991 -0.505803785692636 "MLH1 MUT" "BMS.509744_IC_50" 0.358446190223332 0.786601117838604 0.569752491349486 0.62309707444441 0.950621671427169 -0.228873612853756 0.0614792816145199 0.702860976445846 1.1533567360147 "PTEN MUT" "BAY.61.3606_IC_50" 0.94150155145958 0.989446598697723 -0.0164775097560976 0.623238060219322 0.950621671427169 -0.0787127937499397 0.762515023822793 0.969901216545994 -0.0689871955308847 "ALK MUT" "ATRA_IC_50" 0.453934472179148 0.828966839128293 -0.914968311068722 0.623277303092106 0.950621671427169 -0.474078066801607 0.577060966309482 0.949294892873838 -0.601082999679612 "RUNX1 MUT" "CHIR.99021_IC_50" 0.411941744402114 0.812480994891775 0.52858975736568 0.623361520826845 0.950621671427169 0.298917108094317 0.605025731517448 0.949657634568742 0.357339326378845 "CDKN2A MUT" "BI.2536_IC_50" 0.147375013216478 0.620008286298218 -0.395686843915342 0.62340450103932 0.950621671427169 0.0847003117239551 0.650481086802675 0.957867556929346 -0.14870592425676 "MDM2 MUT" "BIBW2992_IC_50" 0.806398199660119 0.952641225877339 -0.148390597302505 0.6235269916347 0.950621671427169 -0.284615877877583 0.767443996576685 0.969901216545994 -0.164508129442206 "EGFR MUT" "NVP.BEZ235_IC_50" 0.654465028606371 0.900992701759911 0.150553158855639 0.623584559716513 0.950621671427169 0.11970068472916 0.864249692370028 0.987077901072027 0.0572589540260889 "NF1 MUT" "MS.275_IC_50" 0.636619585917787 0.895268363706423 0.293932733497 0.623660263425678 0.950621671427169 -0.254336242637811 0.514326105247264 0.939635632721979 0.479716576698407 "NF1 MUT" "DMOG_IC_50" 0.0972552262035601 0.531849546744961 0.644376558441551 0.623700473963486 0.950621671427169 0.172858805971658 0.581058927196251 0.949294892873838 0.219105350438817 "CDKN2A MUT" "CMK_IC_50" 0.394651114569476 0.803322610243299 -0.175782891954707 0.623817345240923 0.950621671427169 0.0980797199925944 0.288693813366835 0.889281028047524 0.25961706504442 "CCND2 MUT" "Shikonin_IC_50" 0.545542782512008 0.862707523413309 0.71562358203799 0.623817958748198 0.950621671427169 0.485651332748332 0.588239238305449 0.949294892873838 0.764102546606727 "BRCA1 MUT" "CEP.701_IC_50" 0.237947798801706 0.710855542080976 1.09301088190478 0.623855025343544 0.950621671427169 0.334085499259608 0.257555881485973 0.877052916121269 0.947445590409773 "SMAD4 MUT" "Midostaurin_IC_50" 0.798131181110147 0.949524851900765 0.0910396165741729 0.624088507467678 0.950621671427169 0.138576476114487 0.641396403442557 0.955103296458244 0.161881786955994 "STK11 MUT" "ZM.447439_IC_50" 0.200894638574535 0.674012093366938 0.445099061160389 0.624107385279046 0.950621671427169 0.136024443330146 0.592160858173997 0.949294892873838 0.18942553576057 "GNAS MUT" "WH.4.023_IC_50" 0.787057766454161 0.946449577332088 -0.556644211604092 0.624118243306698 0.950621671427169 0.876948616312046 0.982776181355263 0.998011368051263 -0.0417859852242835 "KRAS MUT" "ABT.263_IC_50" 0.133065011323431 0.599873282011872 0.391298443379084 0.624250972237001 0.950621671427169 0.122315392240144 0.342034740577509 0.907180409180092 0.251457349547944 "SMAD4 MUT" "AZD.2281_IC_50" 0.392285199821074 0.803073858340542 0.253237691511389 0.62429382859412 0.950621671427169 -0.112711965250806 0.229280296075219 0.868145256417768 -0.332345480133462 "KIT MUT" "XMD8.85_IC_50" 0.384217547224992 0.798569876743396 -1.12335914383562 0.624299743364816 0.950621671427169 -0.562028931232572 0.90651654888945 0.988917021334873 0.150422366422045 "TP53 MUT" "Cisplatin_IC_50" 0.492186658504073 0.842990705166559 0.104921440389059 0.624320905822505 0.950621671427169 0.0669101407944063 0.698919025741884 0.961100601384891 -0.060822443891573 "FGFR3 MUT" "AUY922_IC_50" 0.832767926519085 0.958751873919626 -0.231441295586525 0.624441177340121 0.950621671427169 0.360335114132138 0.771382088502934 0.969901216545994 -0.303411377710591 "MSH6 MUT" "AUY922_IC_50" 0.970066177007107 0.995166653344128 -0.0252983009666077 0.624631250450066 0.950621671427169 0.221230769133856 0.871848906690632 0.987643979884169 -0.103262372545511 "MLL_AFF1 MUT" "Dasatinib_IC_50" 0.87294626008315 0.970487466477047 0.443627176870746 0.62474215325248 0.950621671427169 1.14460231696949 0.881662634524956 0.988301482344111 -0.361009147820218 "MYC MUT" "Dasatinib_IC_50" 0.193319156186236 0.668382680609485 1.08149157720588 0.624797316854063 0.950621671427169 0.345118780175291 0.764252594981776 0.969901216545994 0.230602377915311 "FLT3 MUT" "KU.55933_IC_50" 0.965389346911169 0.994434372972651 -0.0385874753451685 0.624953632382448 0.950621671427169 -0.388870065402656 0.822704191825365 0.977953923255225 0.196143179020585 "JAK2 MUT" "Bexarotene_IC_50" 0.341036824035077 0.778598466389594 0.581333592230587 0.625189030058227 0.950621671427169 0.265859514044032 0.725412899518047 0.965402608571648 0.222863244329101 "MLH1 MUT" "QS11_IC_50" 0.151899994187021 0.625830613280407 -0.819032915044255 0.625191080858698 0.950621671427169 -0.207932329489308 0.371176224237129 0.913948248824328 -0.502514084801879 "CTNNB1 MUT" "CHIR.99021_IC_50" 0.348380248005146 0.783679073590096 -0.351825731922394 0.625318977983971 0.950621671427169 -0.173437948129819 0.220505743509119 0.864474168037968 -0.498072870644631 "SMARCA4 MUT" "Vorinostat_IC_50" 0.901217895179937 0.979586077148392 0.0501787899999999 0.625673859684202 0.950621671427169 -0.149606682370004 0.692708689083991 0.961100601384891 0.166277288729046 "CDKN2a(p14) MUT" "A.443654_IC_50" 0.0371355139986789 0.351296460573821 -0.522907334166668 0.625770984713401 0.950621671427169 0.08594424149742 0.359719394581268 0.91161229252998 -0.267785014301314 "MET MUT" "TW.37_IC_50" 0.830000489274361 0.958015830101332 0.0884432173913052 0.625937345947759 0.950621671427169 -0.182552548586032 0.555051836310897 0.948071221654821 -0.231942344537591 "MYCL1 MUT" "WH.4.023_IC_50" 0.236989961950113 0.7095832316724 1.73000172183909 0.625953524199778 0.950621671427169 0.630074375982787 0.763511350259682 0.969901216545994 -0.428900743776163 "SMO MUT" "ABT.888_IC_50" 0.776462436547532 0.941591338606299 0.212662049523813 0.625972582129628 0.950621671427169 0.306609324787341 0.922016863751432 0.993931766508607 -0.0683098960197081 "MAP2K4 MUT" "NVP.BEZ235_IC_50" 0.915449533873005 0.98476490303336 0.0478667285327932 0.626036443430691 0.950621671427169 -0.158740929354342 0.433407472601966 0.922569292988365 -0.371277297105399 "PTEN MUT" "ABT.263_IC_50" 0.74103143849784 0.929570057037101 0.0908469292392756 0.626042577118732 0.950621671427169 0.123088345005872 0.924205837057703 0.994026707431102 0.0247453075721259 "CDH1 MUT" "MS.275_IC_50" 0.711070617875029 0.919312211985394 -0.366477251724139 0.62609994581031 0.950621671427169 -0.410379784995181 0.894709446605028 0.988301482344111 -0.139721002460938 "TSC1 MUT" "OSI.906_IC_50" 0.297375074390313 0.748266144511455 1.50384353739132 0.626101012112206 0.950621671427169 0.665432236243252 0.302003726359231 0.894167310052 1.49188153884656 "SOCS1 MUT" "Axitinib_IC_50" 0.842606650026515 0.960245047977092 0.250160060721062 0.626199412658247 0.950621671427169 0.518572138320717 0.712203273194725 0.962630898212352 0.407672955691386 "BRCA1 MUT" "Dasatinib_IC_50" 0.694900806081648 0.913615900582776 -1.08792112244898 0.626326505129026 0.950621671427169 -1.11198888382258 0.595946622850533 0.949294892873838 -1.29734543636979 "CDKN2A MUT" "PD.173074_IC_50" 0.971513521427927 0.995220468612913 -0.00455642246642273 0.626406245380851 0.950621671427169 0.0553765012888542 0.696576333371628 0.961100601384891 -0.051995438291393 "EGFR MUT" "AZ628_IC_50" 0.750590204880809 0.932697982453688 0.275901660839159 0.626474161540915 0.950621671427169 -0.312296149498738 0.998334352014024 0.999689936809094 0.00158177448383663 "SOCS1 MUT" "Nilotinib_IC_50" 0.245284229219728 0.714219422852591 -1.34779562998102 0.626491674422705 0.950621671427169 -0.457773723713843 0.3019010787933 0.894167310052 -1.07580976218789 "KDM5C MUT" "KIN001.135_IC_50" 0.482656108727861 0.839032590911741 0.316462837837841 0.626546394918468 0.950621671427169 0.214849684922351 0.646733574568417 0.957449344088104 0.192543272729347 "MDM2 MUT" "AMG.706_IC_50" 0.94065335157773 0.989446598697723 0.0304886706349208 0.626670744825683 0.950621671427169 -0.183406996040533 0.98726119996977 0.998124818853736 0.00599188604084948 "KIT MUT" "GW.441756_IC_50" 0.838844039819027 0.959212868273494 0.124158182857144 0.626709658098727 0.950621671427169 0.290947419760159 0.949133890045317 0.995668765770473 0.0389279611788049 "MLL_AFF1 MUT" "PD.0332991_IC_50" 0.586769636967965 0.876506729771444 -0.758967084536065 0.626744774929578 0.950621671427169 0.551058336136259 0.28998503051577 0.891022884087089 1.39916970363819 "MET MUT" "AP.24534_IC_50" 0.71346741804674 0.91988693852899 0.309372927877724 0.626786990464678 0.950621671427169 0.37016859666458 0.866413385854812 0.987077901072027 -0.133117262512866 "EP300 MUT" "Axitinib_IC_50" 0.392241795949213 0.803073858340542 0.88064179721165 0.626833342710025 0.950621671427169 0.424507093423263 0.321068098534603 0.900918773778407 0.891775485749122 "SMO MUT" "Bexarotene_IC_50" 0.442157228590524 0.825166478070376 -0.874191966956525 0.627030436085048 0.950621671427169 -0.490423468155593 0.332335145781361 0.903405836635744 -1.04853332639095 "TP53 MUT" "CHIR.99021_IC_50" 0.198116367613131 0.674012093366938 0.161835677355399 0.627222388413809 0.950621671427169 0.0606784489356837 0.552973012462341 0.947568031460906 0.0777353883177572 "CDK6 MUT" "Bosutinib_IC_50" 0.447411174266811 0.826231147407263 0.458959628700127 0.627251994396339 0.950621671427169 0.240530899214628 0.404003218298713 0.917324899625757 0.465830009639932 "NOTCH1 MUT" "AS601245_IC_50" 0.581026359540128 0.875928551871647 0.252023125891267 0.627509733768153 0.950621671427169 0.183104840512454 0.85939690016301 0.985479880500142 0.0881784711413564 "PTEN MUT" "Sunitinib_IC_50" 0.316285825084432 0.761258739353268 0.372219887096774 0.627555426859588 0.950621671427169 0.135091698741404 0.198602780546904 0.851001889249827 0.450547488725434 "CCND1 MUT" "Metformin_IC_50" 0.613042638196632 0.884985642039059 -0.149222735586482 0.62762141123906 0.950621671427169 -0.134388923225025 0.392983231282258 0.915926348152589 -0.26649309308648 "MLLT3 MUT" "Imatinib_IC_50" 0.61518224761252 0.885815598771911 -0.224845605536331 0.627649795942357 0.950621671427169 -0.212233465232709 0.800749577046031 0.976360691959787 -0.125739019078163 "EGFR MUT" "X681640_IC_50" 0.976904711843941 0.996276778834563 -0.0102978181818184 0.627885617353262 0.950621671427169 -0.147669815725542 0.551432367484408 0.947060194029534 -0.208500652807401 "CTNNB1 MUT" "PF.562271_IC_50" 0.545931145633716 0.86289571535809 -0.242406797530862 0.627891968906312 0.950621671427169 0.158750029493537 0.943438551889184 0.995314665488626 0.0314110630427465 "MYCN MUT" "Doxorubicin_IC_50" 0.334609606762203 0.773264085106582 0.428037079892277 0.627948495982355 0.950621671427169 0.137510408136209 0.695889357907509 0.961100601384891 -0.191567748193605 "ERBB2 MUT" "A.770041_IC_50" 0.388500955055922 0.800156999501772 -1.27885026190476 0.628055339340644 0.950621671427169 -0.59460439815642 0.165660602909734 0.84067330207935 -2.00126825474738 "FGFR2 MUT" "AMG.706_IC_50" 0.735948469021657 0.928872455997232 -0.306366582031248 0.62805656802663 0.950621671427169 -0.407945905544777 0.597450143899303 0.949294892873838 -0.623628742244534 "KDM6A MUT" "IPA.3_IC_50" 0.701404092882486 0.915500829364901 -0.175934292052074 0.628133011590163 0.950621671427169 -0.187708990941665 0.778690778660485 0.972337708041191 -0.126929263049594 "FBXW7 MUT" "PF.4708671_IC_50" 0.454506659638787 0.828966839128293 0.238554262672809 0.62823744301958 0.950621671427169 0.152539339403617 0.494161730927007 0.933639405738697 0.231638381373563 "RUNX1 MUT" "TW.37_IC_50" 0.967782437016762 0.994434372972651 -0.0315724689138579 0.628277677673616 0.950621671427169 0.341642720987651 0.895833018985031 0.988301482344111 -0.0971265607818961 "ALK MUT" "Doxorubicin_IC_50" 0.64269298363463 0.896094514063559 0.640766968695656 0.628292968538041 0.950621671427169 0.416739216675601 0.744009386134624 0.967430067095402 -0.604849510801443 "CDK4 MUT" "CGP.60474_IC_50" 0.687639501615431 0.911748124009352 -0.530529755102042 0.628346470343886 0.950621671427169 -0.480083552611747 0.953551666112092 0.99568364368633 0.0752847494222393 "TP53 MUT" "DMOG_IC_50" 0.524755141446245 0.854796480407943 0.0998336153114104 0.628362633667561 0.950621671427169 0.0707547940574941 0.86722392002843 0.987077901072027 -0.0267167630083554 "STK11 MUT" "MG.132_IC_50" 0.954676448851069 0.992679871625456 -0.0606078771331032 0.628408689152888 0.950621671427169 0.4571601570086 0.533486002257826 0.943443271455699 0.703182601000378 "BCR_ABL MUT" "Rapamycin_IC_50" 0.577569535290702 0.873750949722175 -0.845522300675687 0.628549821169817 0.950621671427169 0.80369552796268 0.828623791787735 0.981081757090089 0.339063461618241 "SMO MUT" "AICAR_IC_50" 0.696954523358195 0.914682004129471 0.473147292069627 0.6287505616691 0.950621671427169 0.522907298502831 0.581618600715872 0.949294892873838 0.6402021894439 "NOTCH1 MUT" "Methotrexate_IC_50" 1.87679326369872e-05 0.00282505101269633 -2.63986415747165 0.628769365708623 0.950621671427169 0.242075600805264 0.996511231467144 0.999545005862799 -0.00233572975058281 "TP53 MUT" "Methotrexate_IC_50" 0.972247808319518 0.995220468612913 0.00732695638528277 0.628856229804461 0.950621671427169 -0.0799611250457547 0.233395369796732 0.869962136993019 -0.212113425241174 "JAK2 MUT" "Rapamycin_IC_50" 0.752734256873857 0.933663817778872 0.551432319865313 0.628964087204773 0.950621671427169 0.722648792135974 0.368405913631379 0.913948248824328 1.96674542632246 "CDKN2C MUT" "GDC.0449_IC_50" 0.913733962882759 0.983978576980936 -0.0471652929687502 0.629128031642779 0.950621671427169 -0.18783407333059 0.778249740934887 0.972337708041191 0.130123520201396 "MYC MUT" "CGP.082996_IC_50" 0.193304469819847 0.668382680609485 0.452459276960783 0.62919688704063 0.950621671427169 0.14467117253608 0.771902015375193 0.969901216545994 0.105939121848759 "BRAF MUT" "PF.562271_IC_50" 0.0981320160921992 0.535325819972249 -0.359284599516991 0.629395789497211 0.950621671427169 -0.0944322477761673 0.0781887555746873 0.741811190933953 -0.449248221024694 "CDK6 MUT" "JNK.Inhibitor.VIII_IC_50" 0.446750217050175 0.825892730562573 0.292186499356498 0.62940418062994 0.950621671427169 0.176815170193696 0.549937552026165 0.947060194029534 0.23096465999602 "MAP2K4 MUT" "AP.24534_IC_50" 0.470994671047872 0.832584329931559 -0.559554219278082 0.629465473419023 0.950621671427169 -0.337501519677703 0.171170923009121 0.842832361237713 -1.09721231718725 "MYCN MUT" "ATRA_IC_50" 0.161361964887016 0.636874757939932 -0.564017876570122 0.629626896457145 0.950621671427169 -0.157650184424095 0.757630638155348 0.969901216545994 0.127914208685463 "EZH2 MUT" "WO2009093972_IC_50" 0.492096522275731 0.842990705166559 0.531809898148151 0.62985372233123 0.950621671427169 0.33242195579966 0.718361985288999 0.964721180904622 0.275446686864868 "CCND3 MUT" "Vinorelbine_IC_50" 0.762958660749649 0.936244886169491 -0.306388520761252 0.629892187299361 0.950621671427169 -0.359685347024154 0.576914012994853 0.949294892873838 -0.55731887660803 "MLL_AFF1 MUT" "GNF.2_IC_50" 0.759825048313145 0.935327315103698 0.271925942176872 0.6299217511696 0.950621671427169 0.418478124234385 0.829996873245042 0.981482581683432 0.195022837451499 "NOTCH1 MUT" "JNK.9L_IC_50" 0.185275452889579 0.660550500647272 -0.460902864620135 0.629934356597266 0.950621671427169 -0.135331646408733 0.681474800515307 0.961100601384891 -0.156240781196642 "VHL MUT" "BMS.509744_IC_50" 0.533755674886505 0.858279561609675 0.486027910958904 0.63002116611567 0.950621671427169 0.282178264956107 0.735627605425209 0.96672489654949 0.303155812141268 "MYCL1 MUT" "Pazopanib_IC_50" 0.875599389085709 0.971594429690931 0.0940984356261025 0.630069064552215 0.950621671427169 -0.246202423439317 0.208880273932137 0.853446327418758 -0.752886606364702 "KIT MUT" "BIBW2992_IC_50" 0.317883524900168 0.761258739353268 0.950327861904767 0.630232595026037 0.950621671427169 0.439847286217313 0.890283654819274 0.988301482344111 -0.122251725204349 "BRCA2 MUT" "JNJ.26854165_IC_50" 0.335371701356514 0.773264085106582 0.493297155756199 0.630233341897309 0.950621671427169 0.232799521751186 0.88601708594902 0.988301482344111 -0.0702116006678066 "KRAS MUT" "CMK_IC_50" 0.925627081726128 0.98643792569589 0.0346167211339383 0.630255787562408 0.950621671427169 0.170378670307936 0.633764409522265 0.952523560833852 -0.198273024012784 "MLH1 MUT" "DMOG_IC_50" 0.931454622056294 0.986689293492114 -0.0449095614035088 0.630358182978786 0.950621671427169 0.228700589652023 0.702489371163359 0.962139809888331 0.189375489757232 "ERBB2 MUT" "Nutlin.3a_IC_50" 0.0279827500687142 0.309508303338214 1.00898173535329 0.63077196161706 0.950739830987658 0.209684930922773 0.379542027501038 0.915134825237766 0.417773043809552 "SETD2 MUT" "JNK.Inhibitor.VIII_IC_50" 0.474407932499695 0.834460661638643 0.578860076190492 0.630777710419821 0.950739830987658 0.375971326069115 0.457170048255988 0.925841766232465 0.60616995731946 "IDH1 MUT" "Tipifarnib_IC_50" 0.981711570437284 0.996641260339925 -0.036350580869566 0.630868147527268 0.950739830987658 0.503993074479804 0.871027312071653 0.987549923219873 0.25489044221072 "FAM123B MUT" "Lenalidomide_IC_50" 0.523402652226339 0.854075976778526 0.339912000000004 0.631237262438594 0.950739830987658 0.224634200290952 0.661351559663257 0.958689538788368 0.227171425125994 "APC MUT" "Bexarotene_IC_50" 0.96936665025094 0.994908727710458 0.011388744475954 0.63126167307933 0.950739830987658 0.132312974414125 0.590022379513576 0.949294892873838 -0.185794951345988 "EZH2 MUT" "CMK_IC_50" 0.208278904685284 0.681549356120119 1.08046473972603 0.631340037466748 0.950739830987658 0.376941583988914 0.097755412807908 0.772625185318248 1.66749998821687 "FLCN MUT" "X17.AAG_IC_50" 0.675507967668767 0.908552538148308 0.461109345124283 0.631461500183229 0.950739830987658 0.464219755425054 0.61282779964912 0.949930222127033 -0.68973391922459 "MSH6 MUT" "WO2009093972_IC_50" 0.722526011687215 0.923705342742609 -0.274936444444446 0.631497279401795 0.950739830987658 -0.332376934690041 0.673700545333334 0.960256725054738 -0.321244036267942 "KIT MUT" "JNK.9L_IC_50" 0.183996056237943 0.660385845878234 -0.818970562564982 0.63154760635891 0.950739830987658 -0.231551346074271 0.1935336473101 0.851001889249827 -0.796337494033266 "KDM5C MUT" "Bosutinib_IC_50" 0.55617692172399 0.867684663540343 -0.749235121904777 0.631714289569577 0.950739830987658 -0.504789982084377 0.542476977795693 0.945765861891114 -0.711832906799758 "NOTCH1 MUT" "Gefitinib_IC_50" 0.0196134535828746 0.252811438707561 -1.0237198746186 0.63174438621245 0.950739830987658 0.198338543752796 0.63222881929506 0.952523560833852 -0.206042190617501 "MYC MUT" "Lenalidomide_IC_50" 0.671395045012395 0.906916702390321 0.0732203593562568 0.631915734088629 0.950739830987658 0.0728884730353372 0.61991050726194 0.950496524771391 0.0858421753292121 "FLCN MUT" "AZD6482_IC_50" 0.13702048081646 0.604353219297467 1.31202106239167 0.63191920106448 0.950739830987658 0.356671915297256 0.286139343358118 0.88845489826843 1.18181538640956 "EP300 MUT" "JW.7.52.1_IC_50" 0.306221760483088 0.754830733680498 -1.95118603389829 0.63193528007208 0.950739830987658 0.555069594968965 0.39599292322427 0.916075319394306 -1.64430144434192 "NF2 MUT" "Bicalutamide_IC_50" 0.191731795142559 0.667752969671007 -0.179893055841043 0.632118059383703 0.950853740749773 -0.0633988992395652 0.540394001840095 0.944806105261359 0.0852828981992443 "IDH1 MUT" "Vinorelbine_IC_50" 0.350188382808929 0.784966682190403 -1.33941054310346 0.632340736939145 0.950865764948967 -0.501784143374576 0.480342441227798 0.930304161706959 -1.00056006908925 "STK11 MUT" "EHT.1864_IC_50" 0.732973215263768 0.928342145572949 -0.08880305882353 0.63234087157625 0.950865764948967 -0.123304740713071 0.822201528094792 0.977637136298011 -0.0604354398308922 "NOTCH1 MUT" "CGP.60474_IC_50" 0.31060650511269 0.757204603872028 -0.579007728229661 0.632495063229891 0.950865764948967 0.212149708732435 0.357580511973241 0.91161229252998 -0.590215755315813 "PIK3R1 MUT" "Thapsigargin_IC_50" 0.314699315131016 0.760295053775449 1.02961521265378 0.632554322634669 0.950865764948967 -0.37348205372511 0.434062276000096 0.922569292988365 0.775337046391016 "KIT MUT" "AS601245_IC_50" 0.606467140461777 0.883101274707499 -0.416742293706297 0.632680635416985 0.950886392899262 0.309846892427234 0.99800167086456 0.999689936809094 0.00200736593997063 "EP300 MUT" "JNJ.26854165_IC_50" 0.444985435469065 0.825606373270691 -0.503889318352064 0.632845186528383 0.950886392899262 -0.29560551914462 0.51510267770941 0.939635632721979 -0.40350040638167 "SOCS1 MUT" "X17.AAG_IC_50" 0.23729837230034 0.709759716521808 -1.83640732380956 0.633001595103757 0.950886392899262 -0.653680527418024 0.048286387072086 0.676839988046433 -2.6869173193835 "CDK4 MUT" "AZ628_IC_50" 0.0259215309923042 0.299361660263529 -4.24629955442178 0.633028434761833 0.950886392899262 -0.686333018489686 0.0766068956375964 0.741811190933953 -2.93596915355278 "CDK6 MUT" "Parthenolide_IC_50" 0.926450658441238 0.98643792569589 0.0854034234234239 0.633177660759668 0.950886392899262 -0.407341025987075 0.601011629107186 0.949657634568742 -0.608441337393259 "RUNX1 MUT" "ABT.263_IC_50" 0.759871348159774 0.935327315103698 -0.385027630136988 0.633210463642184 0.950886392899262 -0.53917373760556 0.517437602102911 0.939635632721979 -0.701523441134935 "FAM123B MUT" "Etoposide_IC_50" 0.135270913684031 0.602573270815716 1.64153675563257 0.633549337865059 0.951234432726895 0.340346365005966 0.264197767046584 0.877052916121269 1.17873514412879 "MYCN MUT" "Roscovitine_IC_50" 0.15624183866566 0.63139838220137 0.548444999999999 0.634032749516853 0.951372998609551 0.166939415931679 0.263233276485811 0.877052916121269 0.512759683679537 "EGFR MUT" "FH535_IC_50" 0.849942351170985 0.963526482778845 0.0640065532098571 0.634085012090481 0.951372998609551 0.138675177324202 0.416642702934353 0.922428741067589 0.276577109838077 "FGFR2 MUT" "Bortezomib_IC_50" 0.376310744494289 0.795051761241315 1.15523471558589 0.634105525722244 0.951372998609551 -0.518577190222144 0.700948272499339 0.961100601384891 0.582344843112079 "MS-HL MUT" "Sunitinib_IC_50" 0.813782612020571 0.953913887475092 0.0954245079317575 0.634216024605925 0.951372998609551 0.143315649599045 0.161639032787734 0.839927262232576 0.559923072997857 "FGFR2 MUT" "CGP.60474_IC_50" 0.0372607602256405 0.351296460573821 2.23994033674629 0.634289515405704 0.951372998609551 0.393161429523483 0.785121213627947 0.974788410209674 0.349619531498142 "FGFR3 MUT" "KU.55933_IC_50" 0.805973959548661 0.952641225877339 0.218422386587777 0.634481843468606 0.951372998609551 0.375816941175512 0.979918941342608 0.997827228172038 -0.0219920975759529 "MSH2 MUT" "GNF.2_IC_50" 0.459989039753685 0.828966839128293 0.417633219931274 0.634491488934692 0.951372998609551 0.25760633555733 0.525143937684026 0.940554660491705 0.370383795814192 "MLH1 MUT" "XMD8.85_IC_50" 0.330117983301504 0.771507527963934 0.635089090909088 0.634498622988894 0.951372998609551 0.269983819560623 0.0506990394475381 0.687603690567731 1.26714771150625 "MSH6 MUT" "Sunitinib_IC_50" 0.642167655762204 0.896094514063559 -0.551367886986307 0.634773021851595 0.951390151881966 0.416023440574263 0.576179869264311 0.949294892873838 -0.576131430994577 "IDH1 MUT" "AZD6244_IC_50" 0.501531833073125 0.846336909314253 -1.06665352783503 0.634781136599983 0.951390151881966 -0.68276147086503 0.27128623750011 0.880267838961811 -1.57029341678994 "GNAS MUT" "Doxorubicin_IC_50" 0.163141216175955 0.638639513991862 0.866795389770722 0.63489873635135 0.951390151881966 0.18377628142594 0.354618503829856 0.91161229252998 0.552130082623482 "SOCS1 MUT" "ABT.263_IC_50" 0.81328104695591 0.953913887475092 0.364056173828122 0.634978992725828 0.951390151881966 0.659607219687479 0.248156101154926 0.875707386589409 1.54120768441976 "MAP2K4 MUT" "PHA.665752_IC_50" 0.574723117302055 0.872620551543038 0.446065084175082 0.635045695344701 0.951390151881966 0.375392234006785 0.675190272875634 0.960256725054738 0.415595335147513 "EGFR MUT" "AS601245_IC_50" 0.792294266209075 0.948297220782048 -0.100939823889499 0.635287391096285 0.951591722099192 -0.146519971619715 0.846940979757868 0.98378870157398 -0.0769198279151285 "VHL MUT" "WZ.1.84_IC_50" 0.517486365329592 0.852353345422823 -0.488953195876292 0.635398243519513 0.951597268245666 -0.301483435079322 0.459337149751674 0.927632358897555 0.62126970798953 "EZH2 MUT" "AZD6482_IC_50" 0.669218917401138 0.906776668943588 0.319416902111808 0.635515623376935 0.951612586614494 0.297998992291546 0.462238079255964 0.929276781658587 0.578088192464205 "CDH1 MUT" "AMG.706_IC_50" 0.656098119633134 0.901751651084414 0.203467312252962 0.635797791677715 0.951799690129219 -0.202586842561675 0.573528770178858 0.949294892873838 -0.254818438448498 "KDM5C MUT" "Gefitinib_IC_50" 0.766962161481697 0.937850808294193 0.340879527514229 0.635960396920089 0.951799690129219 0.490221076059167 0.536287662976864 0.943443271455699 0.635799083172254 "ALK MUT" "CEP.701_IC_50" 0.0855093179747766 0.503679085433888 -2.24637676850094 0.636383422382144 0.951799690129219 -0.458766577494753 0.0829464314222708 0.745860856369627 -2.06631231124881 "BRAF MUT" "CMK_IC_50" 0.590193699361922 0.876506729771444 -0.208197883290045 0.636459448598487 0.951799690129219 0.172350658504048 0.833207644283242 0.981482581683432 -0.107516090878147 "MAP2K4 MUT" "LFM.A13_IC_50" 0.397900781927888 0.805826318300581 -0.262204487179483 0.636571513250159 0.951799690129219 -0.138110877447891 0.298251461750689 0.894167310052 -0.353084105543845 "STK11 MUT" "RDEA119_IC_50" 0.690750842328119 0.912932803156675 0.202837302155578 0.63661088078863 0.951799690129219 0.21868098661864 0.187699191000589 0.851001889249827 0.617114505254131 "AKT2 MUT" "SB590885_IC_50" 0.154265885068357 0.629901298984863 1.16428131364563 0.636623119548699 0.951799690129219 0.32266716386514 0.17117920733761 0.842832361237713 0.988151157896518 "TSC1 MUT" "BAY.61.3606_IC_50" 0.636210346571861 0.895149570327107 0.640419076521746 0.63665012766987 0.951799690129219 0.445259676891406 0.304770763700991 0.895767221521364 1.30056960612636 "CCND1 MUT" "RO.3306_IC_50" 0.850444722265936 0.963526482778845 -0.0568260286298564 0.636661148911405 0.951799690129219 -0.136783641388139 0.987560272859789 0.998124818853736 0.00507482179251859 "ERBB2 MUT" "PD.173074_IC_50" 0.914220315885609 0.984363171829944 0.0382735424310568 0.636845498663453 0.951799690129219 -0.147012429764083 0.63633769846946 0.953101495776253 -0.164972327213229 "MLLT3 MUT" "CCT018159_IC_50" 0.682366260114924 0.909924137549646 -0.152071294117648 0.636948702584636 0.951799690129219 -0.162580259503609 0.8165913149522 0.977383317127464 -0.0892881491043553 "KDM5C MUT" "WO2009093972_IC_50" 0.375832588420118 0.795051761241315 0.790570614318718 0.637017922301151 0.951799690129219 0.379277834811846 0.440455365932643 0.924472815010418 0.677162105225891 "MSH2 MUT" "XMD8.85_IC_50" 0.452796872221217 0.828509891052426 -0.616267993079584 0.637121818518216 0.951799690129219 -0.334106041494482 0.812176907515133 0.977383317127464 -0.194557941786449 "CDKN2C MUT" "AZ628_IC_50" 0.722577172237309 0.923705342742609 -0.395061341379311 0.637140992885734 0.951799690129219 -0.392370724653999 0.503234148357816 0.934042323734638 -0.781410028885898 "CCND3 MUT" "Bleomycin_IC_50" 0.856614551284923 0.96514911547635 0.299009293193723 0.637622498703565 0.952186068457798 0.636100737002444 0.630493332416677 0.952523560833852 0.767490096475634 "PDGFRA MUT" "Docetaxel_IC_50" 0.412217302771217 0.812480994891775 -0.665816605825247 0.637840702344905 0.952186068457798 -0.286896117240895 0.785365095218856 0.974807190013589 -0.21645607046759 "FLCN MUT" "CMK_IC_50" 0.458819505785628 0.828966839128293 0.733885224118314 0.637892419797863 0.952186068457798 0.425316285989104 0.693592883506101 0.961100601384891 0.705521238805621 "PTEN MUT" "PHA.665752_IC_50" 0.856688028642036 0.96514911547635 0.0389735317460313 0.637895099416676 0.952186068457798 0.102745480189253 0.448206068687955 0.925809648901546 0.180852764859056 "NRAS MUT" "CHIR.99021_IC_50" 0.903136330663662 0.979694707150557 0.0279715550264552 0.638034713320241 0.952186068457798 -0.105744205040993 0.86711644231941 0.987077901072027 0.042435865715779 "MAP2K4 MUT" "FH535_IC_50" 0.706106248382963 0.916471600847684 -0.16817247804146 0.63823155462186 0.952186068457798 0.179691895488654 0.699275455161507 0.961100601384891 0.181334590232408 "MS-HL MUT" "Bicalutamide_IC_50" 0.988117190300121 0.997992312673585 0.00118537087755225 0.638463116918241 0.952186068457798 -0.0358596999374737 0.519795627430474 0.939635632721979 -0.0534638476321986 "SETD2 MUT" "SB590885_IC_50" 0.224622653917943 0.696147159126308 1.56481434210524 0.638497031270519 0.952186068457798 0.509351178559982 0.474106848038085 0.929753746451187 0.807860667384876 "NF2 MUT" "ABT.888_IC_50" 0.638590760601464 0.895624997957207 0.11057302333898 0.638823773688219 0.952186068457798 -0.0939072837220749 0.577694425405337 0.949294892873838 -0.131078336045919 "NOTCH1 MUT" "Lapatinib_IC_50" 0.111662419821479 0.563072279454009 0.86904329666774 0.638828934460025 0.952186068457798 0.233469245519836 0.972284926818049 0.99742775226181 -0.0192496196485164 "MSH6 MUT" "PHA.665752_IC_50" 0.677954282860461 0.908720747099578 -0.286405979729732 0.639128031182693 0.952186068457798 -0.321350739165334 0.628892961420299 0.952431828758317 -0.339128801012306 "CDK4 MUT" "PF.02341066_IC_50" 0.726952366000113 0.92560056809276 0.402907855704696 0.639208404630332 0.952186068457798 0.502004113004163 0.381834245822645 0.915134825237766 0.994510104131537 "KIT MUT" "PF.562271_IC_50" 0.213128339003284 0.687763182315503 -0.857664181975728 0.639313959907918 0.952186068457798 -0.263971934208233 0.325746729981108 0.900918773778407 -0.66597791467035 "KIT MUT" "PLX4720_IC_50" 0.537433960639584 0.86087328699965 0.585011301343572 0.639362571533755 0.952186068457798 0.39551370380831 0.588491477461561 0.949294892873838 0.468913751667276 "CDK6 MUT" "ABT.888_IC_50" 0.95431354017054 0.992679871625456 -0.0203650291720285 0.639535615800147 0.952186068457798 -0.140269533495419 0.641936056908758 0.955267111495758 -0.154403808574112 "NF1 MUT" "Bortezomib_IC_50" 0.959090375769747 0.993456347206305 -0.0327613033432994 0.639574467132103 0.952186068457798 -0.24427287202838 0.570832729536617 0.949294892873838 -0.391831545678587 "APC MUT" "Vinorelbine_IC_50" 0.198266358663558 0.674012093366938 0.473370088636367 0.639762124994277 0.952186068457798 0.132882086983278 0.841130822768878 0.982150602679453 0.0885611730427533 "SETD2 MUT" "Parthenolide_IC_50" 0.425824096976686 0.819381892124907 0.900352289562278 0.639784056663266 0.952186068457798 0.49812878058016 0.378222052846963 0.914597095447912 1.03461636457934 "SOCS1 MUT" "Camptothecin_IC_50" 0.843236132901643 0.960498931426639 0.314813667931685 0.639788836287005 0.952186068457798 0.471645741211235 0.531817394622509 0.94320946427311 0.877104917113076 "CDK6 MUT" "TW.37_IC_50" 0.952668791537881 0.992561499112566 -0.0285738772727273 0.639819380325999 0.952186068457798 -0.203356428289863 0.930888772421293 0.99422596912377 -0.0398093576054262 "SETD2 MUT" "EHT.1864_IC_50" 0.631363730954043 0.893419864692589 -0.430034821428569 0.639825708393652 0.952186068457798 -0.420986064406684 0.290487429555116 0.891022884087089 -0.920948843521546 "KDM6A MUT" "Salubrinal_IC_50" 0.178447474401788 0.657660823713238 -0.655506601200215 0.639873985623465 0.952186068457798 -0.188302430454142 0.0860562123377266 0.750751691327456 -0.911252126520753 "NF2 MUT" "BMS.754807_IC_50" 0.602028469471907 0.880745626033854 -0.266849616906477 0.639882207559788 0.952186068457798 0.201649909997029 0.801311329888509 0.976360691959787 0.136182731151684 "CCND3 MUT" "QS11_IC_50" 0.896284385052967 0.977274600817115 0.12826991797557 0.640092017563007 0.952186068457798 -0.338770585003905 0.956753543833462 0.996361528879345 -0.0521192422034416 "PIK3R1 MUT" "X681640_IC_50" 0.171501273379919 0.649721929411943 0.794174552361386 0.640104901003744 0.952186068457798 0.232093452468532 0.473806163652589 0.929505752020906 0.389362564992281 "FLT3 MUT" "AZD.2281_IC_50" 0.635144238175135 0.894641709632574 -0.411388944773183 0.640238349566776 0.952186068457798 0.309527444910562 0.494071789426239 0.933639405738697 0.523318093804924 "VHL MUT" "Methotrexate_IC_50" 0.248594184523058 0.715413140877926 0.910440983772841 0.640294471436772 0.952186068457798 0.282606737059009 0.735830879254209 0.96672489654949 -0.229006404535812 "CDKN2A MUT" "Methotrexate_IC_50" 0.990462571989494 0.998036562927507 0.00237434387935202 0.640561941898731 0.952273003893711 -0.0735357571974696 0.281679373077087 0.887872038823822 -0.191503120405455 "MLH1 MUT" "BIRB.0796_IC_50" 0.47716665344433 0.835993679974334 -0.2633266384778 0.640567382643963 0.952273003893711 -0.167756027332588 0.569382228951451 0.949294892873838 -0.210513010733686 "FGFR3 MUT" "Embelin_IC_50" 0.892001353292145 0.975972789421281 -0.112516684088268 0.640683333217122 0.952282986334224 0.308731718712672 0.769152242999209 0.969901216545994 -0.239880727838089 "SOCS1 MUT" "ABT.888_IC_50" 0.290660157257604 0.746560070213055 -0.791047093333349 0.640788551552001 0.952282986334224 -0.295178845648727 0.601736492327304 0.949657634568742 -0.365176418332521 "MAP2K4 MUT" "Bryostatin.1_IC_50" 0.367854034062719 0.789246419666677 -0.318352441625746 0.641062218822967 0.952468033185198 -0.155357493897909 0.589167836078093 0.949294892873838 -0.2005976653126 "STK11 MUT" "Dasatinib_IC_50" 0.4937942326317 0.843282996121548 -1.20629694158076 0.641171368899541 0.952468033185198 -0.679035848537324 0.890574769940429 0.988301482344111 0.240638786512182 "MS-HL MUT" "Elesclomol_IC_50" 0.847687898026446 0.962618339080162 0.056158599666189 0.641332785586525 0.952468033185198 0.113287930948621 0.59231117078857 0.949294892873838 -0.161678394918529 "ALK MUT" "Axitinib_IC_50" 0.399856212481544 0.805918367644724 -1.0603189914611 0.64134206040395 0.952468033185198 0.497501372264815 0.513493569347304 0.939635632721979 -0.727290729119959 "RB1 MUT" "Bryostatin.1_IC_50" 0.107709956448915 0.552948315127282 0.264946371049044 0.641615956294561 0.952686184777899 0.0742662500840026 0.607258629889611 0.949657634568742 0.0918998421340037 "NRAS MUT" "Temsirolimus_IC_50" 0.390634009640122 0.801837403580487 -0.329551209561582 0.641703497054543 0.952686184777899 -0.141772899938838 0.846889896537269 0.98378870157398 -0.0800281143086853 "MLL_AFF1 MUT" "Sunitinib_IC_50" 0.0149272105648863 0.222289121053521 -4.05103633673471 0.6419189364792 0.952846744922577 -0.584901679633425 0.0399138429534153 0.650412549117947 -3.00498179674072 "FAM123B MUT" "NVP.BEZ235_IC_50" 0.100556358956507 0.539275980611557 1.46548096215141 0.642061117029069 0.952898526125528 0.29980079232653 0.492097685427534 0.933639405738697 0.586834299564891 "MAP2K4 MUT" "Nilotinib_IC_50" 0.490511333112137 0.84270247622041 0.329806437137334 0.642246014294707 0.953013676349423 0.180280352108635 0.83234728053255 0.981482581683432 -0.100835678650037 "CDKN2a(p14) MUT" "Docetaxel_IC_50" 0.104707957314301 0.547328645619958 -0.263752291083765 0.642413763883278 0.953082280102729 0.0589396321014721 0.878472439451431 0.987955687349291 -0.0267532082686761 "CCND3 MUT" "Pazopanib_IC_50" 0.634084826600374 0.89399270048764 -0.449954404450272 0.642506881091661 0.953082280102729 -0.373849211243121 0.759153245416522 0.969901216545994 -0.264920901515311 "NF2 MUT" "GSK269962A_IC_50" 0.101714960831162 0.542024654294532 -1.21436773519164 0.642668856279542 0.953163345460691 -0.332466030614755 0.914580658160489 0.991139820027249 -0.0873152382932023 "TP53 MUT" "BMS.754807_IC_50" 0.901272135613052 0.979586077148392 0.0251352495905469 0.642864585625253 0.953294437291346 0.0813161351719461 0.851202257062078 0.984550422117456 0.0402417064883686 "MET MUT" "Bicalutamide_IC_50" 0.505265437821536 0.847679261741881 -0.125791105043367 0.643201186681635 0.953395135123659 -0.0835237980735331 0.925749523158846 0.994026707431102 0.0165274977819929 "KDR MUT" "GW.441756_IC_50" 0.801563817021479 0.9507092914502 0.176998138783271 0.643301368852016 0.953395135123659 0.31828521272999 0.9765589687601 0.99742775226181 0.0207378891578569 "CDKN2C MUT" "Lenalidomide_IC_50" 0.853782501201692 0.964541653680809 0.0696957773512468 0.643360460021974 0.953395135123659 -0.154151316687856 0.536879902778115 0.943443271455699 0.239742562716408 "RB1 MUT" "Gemcitabine_IC_50" 0.890377340008978 0.975801867105169 -0.0730620987368804 0.643479412431461 0.953395135123659 -0.168251181831402 0.0388269559820009 0.646945958867072 -1.16177272951887 "MSH6 MUT" "CMK_IC_50" 0.504885093221181 0.847679261741881 -0.573131150684938 0.643505536663293 0.953395135123659 -0.364578029163741 0.437422357431095 0.922569292988365 -0.678958952906816 "MYCN MUT" "AP.24534_IC_50" 0.522379667085781 0.853303159804623 0.412925400205668 0.643609554560891 0.953395135123659 0.276413651776186 0.228933704731518 0.868145256417768 -0.842766174601679 "GNAS MUT" "CGP.082996_IC_50" 0.366641555102753 0.788882799008227 -0.856347474402725 0.643839685983984 0.953395135123659 -0.369316803004216 0.440303811958772 0.924472815010418 -0.728087100380424 "KDM6A MUT" "WH.4.023_IC_50" 0.589966439433429 0.876506729771444 -0.491779603571426 0.643934414551865 0.953395135123659 0.368232627055453 0.284025953922238 0.8879937007725 -0.993141428001745 "KDR MUT" "Epothilone.B_IC_50" 0.73293729298765 0.928342145572949 -0.461028765389075 0.644135193618293 0.953395135123659 0.355769609314314 0.697070800463251 0.961100601384891 -0.518433946702684 "MSH6 MUT" "Cyclopamine_IC_50" 0.395858853582998 0.804008910182289 -0.631520862068972 0.644177571163772 0.953395135123659 -0.316244355433654 0.408991704435343 0.920903133902018 -0.611496680015804 "MDM2 MUT" "PLX4720_IC_50" 0.571791471203724 0.872389778906173 0.341206238834951 0.644256545682928 0.953395135123659 -0.247302430573435 0.418446004788343 0.922428741067589 0.440104991838656 "RUNX1 MUT" "Cisplatin_IC_50" 0.510238340232136 0.849377075839099 -0.632059366920149 0.644290717158256 0.953395135123659 -0.383436829902325 0.5533711329849 0.947645397616448 -0.540683294915904 "MLLT3 MUT" "Bexarotene_IC_50" 0.407464059855532 0.809352267869285 -0.295690193645086 0.644570786379033 0.953395135123659 -0.145972983831725 0.761035250531101 0.969901216545994 -0.108355278246735 "VHL MUT" "AMG.706_IC_50" 0.802944680804828 0.951554805207856 0.114025217391296 0.64474629518298 0.953395135123659 0.194974880942516 0.930064597143497 0.99422596912377 0.04009929519602 "JAK2 MUT" "AKT.inhibitor.VIII_IC_50" 0.89388147573522 0.976022725555062 -0.0812280290683261 0.644823409525458 0.953395135123659 -0.240806310644067 0.985479854850257 0.998124818853736 -0.0117751387074554 "SOCS1 MUT" "RO.3306_IC_50" 0.564740199090526 0.871775968539349 -0.599532929687494 0.644924197321463 0.953395135123659 -0.458366558695595 0.623435557267735 0.950496524771391 -0.510046726284785 "KDM6A MUT" "Epothilone.B_IC_50" 0.533040552999398 0.858279561609675 -0.323412870674891 0.645102346186578 0.953395135123659 0.136994917588971 0.911723004809464 0.990339041794625 -0.0594405831100416 "HRAS MUT" "Vinblastine_IC_50" 0.27264871414539 0.734000646544246 -0.804192062460161 0.645107238296712 0.953395135123659 -0.244801243835927 0.245102592961456 0.875707386589409 -0.799400264368312 "KDR MUT" "MK.2206_IC_50" 0.775397236900492 0.941591338606299 0.295015252066113 0.645221642085776 0.953395135123659 0.379879338753875 0.819293250100795 0.977383317127464 0.233113637155712 "RUNX1 MUT" "AZD6482_IC_50" 0.248784793335579 0.715488629021978 1.01799506585788 0.645296098082591 0.953395135123659 0.341846556523791 0.600515310013164 0.949657634568742 0.501801507179462 "KRAS MUT" "WZ.1.84_IC_50" 0.96164156382629 0.993987282162626 0.0174960758082493 0.645469792971393 0.953395135123659 0.147393397847091 0.61684935282505 0.950247055931602 0.189556651636902 "SMARCA4 MUT" "BMS.536924_IC_50" 0.809538878764269 0.952641225877339 0.34569966666667 0.645527860189882 0.953395135123659 0.489328180016325 0.941573308600463 0.995314665488626 -0.171156633213434 "BRAF MUT" "Bortezomib_IC_50" 0.0399886615852794 0.361141839503332 -1.09281729146875 0.645628940233722 0.953395135123659 -0.218439617970787 0.768334584002126 0.969901216545994 -0.194021265007991 "KDR MUT" "JNK.Inhibitor.VIII_IC_50" 0.926871071801374 0.98643792569589 -0.0607156997455477 0.645689898385199 0.953395135123659 -0.290436039084827 0.846556451927267 0.98378870157398 -0.13026966505281 "NF2 MUT" "XMD8.85_IC_50" 0.644399910502802 0.896446680008675 -0.27033221830986 0.645698241470875 0.953395135123659 0.239746853338489 0.676492528386179 0.960256725054738 -0.263931094080145 "PIK3R1 MUT" "Embelin_IC_50" 0.163045232284651 0.638639513991862 0.710397016695959 0.645723650238578 0.953395135123659 0.187109846111047 0.322340869647296 0.900918773778407 0.496682313709328 "KIT MUT" "AP.24534_IC_50" 0.907555730113948 0.981251818741413 -0.144362738301558 0.64612400198129 0.953813731733274 0.515080148254269 0.665042322218892 0.959206771190239 0.506984621977141 "ALK MUT" "NSC.87877_IC_50" 0.456444080117681 0.828966839128293 0.590374655172413 0.646221959671108 0.953813731733274 0.358027537304034 0.950661697568906 0.995668765770473 0.0701474231246264 "ERBB2 MUT" "X681640_IC_50" 0.037245522367854 0.351296460573821 0.836664212896879 0.646372756954064 0.953877775757567 0.164010938738955 0.686772967791454 0.961100601384891 0.163017156578914 "NF1 MUT" "Erlotinib_IC_50" 0.386148673556662 0.798891741838427 0.458222447026657 0.646626543910599 0.953981142382178 0.218004230358321 0.317373402382011 0.900918773778407 0.542577922282024 "STK11 MUT" "GW843682X_IC_50" 0.910695303618777 0.98209025378808 0.123369184246574 0.64689594155021 0.953981142382178 0.26030699534266 0.963607450602475 0.997051031866061 0.0592733326475908 "ALK MUT" "GSK269962A_IC_50" 0.809400621406411 0.952641225877339 0.323561700680274 0.646920400999606 0.953981142382178 0.574983634706138 0.427982680458317 0.922428741067589 1.29881451504809 "GNAS MUT" "GDC0941_IC_50" 0.782188543394213 0.944314407151708 0.178996320686069 0.646963447683686 0.953981142382178 -0.23804891461068 0.893215032111488 0.988301482344111 -0.0861662645640723 "FLCN MUT" "Cytarabine_IC_50" 0.819113724593522 0.95524539465489 0.227714582857144 0.647052739319776 0.953981142382178 0.34523995214786 0.524246907488956 0.940554660491705 -0.827417824066434 "BRAF MUT" "Cytarabine_IC_50" 0.452269512561298 0.828509891052426 -0.212370665132338 0.647135919452042 0.953981142382178 -0.108138087573911 0.205091376995834 0.853446327418758 -0.395213579773932 "MET MUT" "Embelin_IC_50" 0.245573717963428 0.714359708232298 -0.505779988756829 0.647223011161512 0.953981142382178 -0.159900231172984 0.22189433530877 0.865076203633533 -0.527346684295272 "NF1 MUT" "PD.0332991_IC_50" 0.939809816659566 0.989446598697723 -0.0348300491452994 0.647403977422884 0.953981142382178 -0.170402891866139 0.867862704025882 0.987342922214615 -0.0791507093097168 "AKT2 MUT" "Parthenolide_IC_50" 0.694153516176758 0.913435675976558 0.444754814814812 0.647409564816731 0.953981142382178 0.476395464099973 0.650295742435866 0.957867556929346 0.529586940705482 "FGFR2 MUT" "GSK269962A_IC_50" 0.220352614049844 0.693216990923367 1.64208006802722 0.647674654822496 0.954077893406145 0.586939363581249 0.797466704018554 0.976360691959787 0.418136368652782 "KDM6A MUT" "Temsirolimus_IC_50" 0.220151887166471 0.692830939023895 -0.709396579678359 0.64769008212427 0.954077893406145 0.203120755455441 0.181625547278579 0.84916206298285 -0.758725928912819 "CDK6 MUT" "GDC0941_IC_50" 0.750360223960195 0.932697982453688 -0.205989516112267 0.648254362580447 0.954497531452318 -0.236733557284928 0.693155637235646 0.961100601384891 -0.252853470061426 "SMO MUT" "AKT.inhibitor.VIII_IC_50" 0.393197798333642 0.803073858340542 -0.968192467241395 0.648358982511967 0.954497531452318 -0.44175671688762 0.512023303324966 0.939326369929565 -0.72342159403176 "BRAF MUT" "BAY.61.3606_IC_50" 0.631486648159393 0.893419864692589 -0.12996962347614 0.648519504235231 0.954497531452318 -0.0947751927427827 0.160051047506989 0.838901067822678 -0.427379470735386 "FBXW7 MUT" "Lapatinib_IC_50" 0.479762961113454 0.836304203722611 0.404899042553193 0.64853188912696 0.954497531452318 0.229102968795435 0.864094818965149 0.987077901072027 0.0891248970260314 "TP53 MUT" "Etoposide_IC_50" 0.487326296200431 0.841030866023325 0.149176106561278 0.648787256541866 0.954497531452318 0.0655360384448889 0.597901473142118 0.949294892873838 0.115784597577883 "MAP2K4 MUT" "Shikonin_IC_50" 0.898789288612218 0.978795346528664 -0.0729820492091358 0.648858742011691 0.954497531452318 0.219810685538771 0.748226191321687 0.968780465757047 -0.197510190899187 "CDKN2C MUT" "KU.55933_IC_50" 0.688430637730477 0.911852590910835 0.179345434131736 0.64886237169708 0.954497531452318 0.18191914011885 0.441453678949201 0.924472815010418 0.363285341801455 "CDH1 MUT" "Z.LLNle.CHO_IC_50" 0.981715769108621 0.996641260339925 0.0187669037800685 0.648889134283818 0.954497531452318 0.352591667914555 0.854964879209511 0.984631915507353 0.149436987893567 "BRAF MUT" "FH535_IC_50" 0.00444238580956728 0.112081898791952 -0.638956566805988 0.648942246921416 0.954497531452318 -0.0967273945645295 0.361639756858672 0.91161229252998 -0.235440138150777 "CCND1 MUT" "ATRA_IC_50" 0.487719025895631 0.841054887180408 0.2452615748503 0.649328465027614 0.954852348226596 -0.127509485101704 0.701221576889169 0.961100601384891 -0.128238042561616 "NOTCH1 MUT" "JNJ.26854165_IC_50" 0.923639412983744 0.98643792569589 0.0548412612612614 0.649398511799194 0.954852348226596 0.241716653587866 0.941796145655637 0.995314665488626 -0.0391988675603108 "CDKN2C MUT" "Temsirolimus_IC_50" 0.499264333499862 0.845109283443017 -0.548839759596928 0.649528744336922 0.954885743826552 -0.282919277933823 0.961194646240654 0.996625877572729 -0.0401838648082531 "MLLT3 MUT" "Vorinostat_IC_50" 0.686185575183798 0.911730003936733 0.1195707136885 0.649655359806358 0.954913811724639 0.10231296686549 0.7085655925066 0.962630898212352 0.105649750114263 "BRCA1 MUT" "Z.LLNle.CHO_IC_50" 0.68412327691407 0.910626322283251 0.523994397959184 0.649839720259034 0.955026734340639 0.537527993334773 0.73538001531019 0.96672489654949 0.42962843121397 "RB1 MUT" "Dasatinib_IC_50" 0.183351733033475 0.660385845878234 0.856817776082358 0.649998563499597 0.955085574790587 0.252441847023779 0.347864928683297 0.909999728614578 -0.617200837777201 "FLCN MUT" "Sorafenib_IC_50" 0.995940819097302 0.998977896287767 0.00546224829932011 0.650177550332568 0.955085574790587 -0.461986522635187 0.750054582142599 0.968780465757047 -0.62216499560513 "MLLT3 MUT" "TW.37_IC_50" 0.447229149561684 0.826231147407263 0.261020208333336 0.650371363889519 0.955085574790587 0.140573112665021 0.470617020959326 0.929276781658587 0.243147418303504 "FGFR2 MUT" "AS601245_IC_50" 0.00902015558773289 0.166544702234212 2.35315200349043 0.650525321625572 0.955085574790587 0.333037405254758 0.0398315340913608 0.650264437987822 2.11283636411529 "CDK4 MUT" "Elesclomol_IC_50" 0.286510668922601 0.741305709900881 0.740781171483625 0.650603315913223 0.955085574790587 0.26215922293602 0.387178018403413 0.915785792511616 0.595322878224382 "MLLT3 MUT" "PD.173074_IC_50" 0.957442273860153 0.993340772343095 -0.018445351702509 0.650635974491721 0.955085574790587 -0.133840215594426 0.933747036435267 0.994729228933513 -0.0277922191301963 "NOTCH1 MUT" "Imatinib_IC_50" 0.99562363379708 0.998977896287767 0.00224786295005863 0.650695581422901 0.955085574790587 0.192568524380883 0.832494454004572 0.981482581683432 0.105541185763061 "CDKN2C MUT" "VX.702_IC_50" 0.651327747568724 0.899243470992269 0.241255000000002 0.650740098306254 0.955085574790587 -0.198344590410006 0.497430877063927 0.934042323734638 0.360735900670708 "EP300 MUT" "GNF.2_IC_50" 0.455601299573873 0.828966839128293 -0.663393785714287 0.650914360042449 0.955183481747685 -0.38361224602343 0.881731856055493 0.988301482344111 -0.134598009194685 "PIK3R1 MUT" "VX.680_IC_50" 0.17430562844899 0.651792962633888 1.6084715773196 0.651121177903863 0.955227409947018 -0.347978138521959 0.225446579213022 0.86643108387559 1.46889333911604 "KDR MUT" "AKT.inhibitor.VIII_IC_50" 0.291610141213108 0.746611418788718 -0.97708520034542 0.651261660242503 0.955227409947018 -0.359136799994496 0.258282958197131 0.877052916121269 -1.03350601307734 "MAP2K4 MUT" "JNK.9L_IC_50" 0.972073636111142 0.995220468612913 0.0134874090847643 0.651322107487141 0.955227409947018 0.135818073596739 0.935609696367903 0.994729228933513 -0.0339368050609002 "CDK4 MUT" "Metformin_IC_50" 0.491722151765719 0.842990705166559 0.332839242132304 0.651563087410865 0.955227409947018 -0.203981709466058 0.887307200314866 0.988301482344111 0.0708809505189426 "EP300 MUT" "GSK269962A_IC_50" 0.357707464546785 0.786601117838604 -1.50752662711863 0.651660785328573 0.955227409947018 -0.692039037756751 0.966018353556092 0.997172246847904 0.0695761944256749 "NF1 MUT" "NVP.TAE684_IC_50" 0.802896066488215 0.951554805207856 -0.180535020833334 0.651738964732964 0.955227409947018 -0.270115548043366 0.926256494164221 0.994088691803316 -0.0774856330527635 "SMAD4 MUT" "CI.1040_IC_50" 0.920550935365461 0.986016435821543 0.0352406893045347 0.6517404188552 0.955227409947018 -0.146488294423329 0.832063895341869 0.981482581683432 0.0702034199341134 "PIK3R1 MUT" "PLX4720_IC_50" 0.805413122775442 0.952510646223648 0.165907181818182 0.652049721352238 0.955227409947018 -0.269471365256397 0.74051028099867 0.96672489654949 -0.201435002365585 "CTNNB1 MUT" "CGP.082996_IC_50" 0.868958727263822 0.969013367256404 0.111304563218392 0.652115663524323 0.955227409947018 0.25357924110911 0.366088693361276 0.913948248824328 0.66970607837213 "MSH6 MUT" "Paclitaxel_IC_50" 0.445871182308684 0.825892730562573 -0.998988484641631 0.652267793041706 0.955227409947018 0.25932900267872 0.324334930374146 0.900918773778407 -1.28143155307659 "CDK4 MUT" "AZD6482_IC_50" 0.787395404450817 0.946449577332088 -0.188790656794426 0.65230539361835 0.955227409947018 -0.267617854297534 0.934643806612127 0.994729228933513 -0.05951040868874 "CDKN2C MUT" "WO2009093972_IC_50" 0.507932731779709 0.8480824574047 -0.458952306264502 0.652308936652039 0.955227409947018 0.283594756072901 0.681670365857907 0.961100601384891 0.315339847779067 "FLT3 MUT" "Rapamycin_IC_50" 0.443662367249893 0.825606373270691 -1.34028148484846 0.652342556168074 0.955227409947018 0.683148666180219 0.853383918758827 0.984631915507353 -0.330042829184507 "MSH6 MUT" "CI.1040_IC_50" 0.723507104635589 0.923974852378165 -0.240701859895401 0.652643704957181 0.955510838068698 0.273748770161268 0.448989276044935 0.925809648901546 -0.451609777240211 "MLLT3 MUT" "Temsirolimus_IC_50" 0.616709587569725 0.885815598771911 -0.266679956759544 0.653186903407713 0.956148490055035 -0.182425508829653 0.75230786230716 0.968780465757047 -0.167272043791003 "CDK4 MUT" "AKT.inhibitor.VIII_IC_50" 0.760997040062443 0.93574319967042 0.173402443379792 0.653490575786708 0.956398940828938 0.220654708883588 0.807976045302168 0.977383317127464 0.143673337898428 "PDGFRA MUT" "Bicalutamide_IC_50" 0.488936087328648 0.841958671689735 -0.192774405594406 0.65357337821088 0.956398940828938 -0.118975119692281 0.785852273560177 0.974807190013589 -0.0721081348836048 "MET MUT" "ATRA_IC_50" 0.211651166759127 0.685512039382861 0.628746345654995 0.653971289836879 0.956823562609772 0.178198579044817 0.961758758464426 0.996625877572729 -0.0211547972317237 "KDR MUT" "PD.0332991_IC_50" 0.827860853115677 0.958015830101332 0.248207153581263 0.654364133927494 0.956935923671071 0.407923412090271 0.691571942259022 0.961100601384891 0.428723166632464 "VHL MUT" "MS.275_IC_50" 0.678788407107972 0.908837606441414 0.527104276255708 0.654364677532441 0.956935923671071 0.475626928892177 0.894996515096377 0.988301482344111 0.181325238820919 "EP300 MUT" "Cisplatin_IC_50" 0.347891428375564 0.782976121490973 -0.900850368187566 0.654459852395975 0.956935923671071 -0.373794205710297 0.322855132680333 0.900918773778407 -0.903509336977715 "SETD2 MUT" "BMS.708163_IC_50" 0.378679522209523 0.795952477739693 0.756933979910711 0.654479090235119 0.956935923671071 0.392220141015243 0.436979540833517 0.922569292988365 0.676134975906 "APC MUT" "SB590885_IC_50" 0.887741739587404 0.975214727041194 0.0499852854090347 0.654697339404724 0.957044788731205 0.140093142153089 0.163379980530934 0.839927262232576 0.532974209186121 "APC MUT" "S.Trityl.L.cysteine_IC_50" 0.742915037684192 0.929570057037101 -0.21029807751196 0.654977211115325 0.957044788731205 0.160484251211359 0.492961123878181 0.933639405738697 0.53015693278717 "KRAS MUT" "BMS.509744_IC_50" 0.0822739558536265 0.497735014942818 -0.651779774674704 0.655322682795553 0.957044788731205 -0.131667859177414 0.131939188959872 0.824721122422311 -0.608769941654573 "KIT MUT" "AG.014699_IC_50" 0.572255487570093 0.872389778906173 -0.407798533783785 0.655370978566734 0.957044788731205 0.285166925443163 0.833630891108091 0.981482581683432 -0.14156900074193 "SMARCA4 MUT" "AICAR_IC_50" 0.811273714203116 0.953031991512947 0.130763516699411 0.655452844391871 0.957044788731205 -0.217278265333716 0.57911962108982 0.949294892873838 -0.332756022821926 "PTEN MUT" "GW843682X_IC_50" 0.872325399223524 0.970405187398056 0.0617795130522093 0.655473176702394 0.957044788731205 0.0898559802414291 0.985047400727254 0.998124818853736 0.00806650674360902 "CTNNB1 MUT" "WH.4.023_IC_50" 0.488982386580666 0.841958671689735 -1.01304899080461 0.655476835577437 0.957044788731205 0.56540377128806 0.841134268600746 0.982150602679453 -0.304741650868595 "JAK2 MUT" "GSK.650394_IC_50" 0.41811216360495 0.814099702076568 0.640631189473694 0.655490760114292 0.957044788731205 -0.228166060729104 0.457877106254165 0.926499562689278 0.635943126481532 "BRCA2 MUT" "Docetaxel_IC_50" 0.0749499171528662 0.480599432660364 1.61309389147287 0.655523415139277 0.957044788731205 0.303838155911111 0.197759016279248 0.851001889249827 1.12910664922895 "CCND1 MUT" "CGP.082996_IC_50" 0.590188301567912 0.876506729771444 0.259562875586854 0.656035595568536 0.957481814477241 0.184378541942104 0.72596780764961 0.965402608571648 0.194171835670088 "MLLT3 MUT" "Docetaxel_IC_50" 0.84080934575168 0.959488317577174 0.0848510675491112 0.656038378684158 0.957481814477241 0.141301683675754 0.512522737558454 0.939635632721979 0.279253404797038 "KDM6A MUT" "X681640_IC_50" 0.614266433436658 0.885815598771911 -0.197340498951782 0.656310580170191 0.957581345146072 0.150542818823859 0.615646559512356 0.950126768674963 -0.190361886092178 "FLCN MUT" "VX.680_IC_50" 0.149225628174264 0.624539492844318 2.19660433105801 0.656322221360673 0.957581345146072 0.440596630302444 0.446730358294882 0.925809648901546 2.1142565118633 "MYCL1 MUT" "Bleomycin_IC_50" 0.736786159123999 0.929060655945983 -0.353628098059967 0.656755977610783 0.957745603726178 -0.381523191138467 0.0317455996798096 0.617683870699155 -2.37243112621468 "APC MUT" "PHA.665752_IC_50" 0.555865175419036 0.867599054990591 0.24788129285939 0.656947739727422 0.957745603726178 0.192109780747655 0.309897990557087 0.89718581932126 0.517424259300813 "MYC MUT" "AZD6244_IC_50" 0.909470756929179 0.981529929795606 -0.0420422312080538 0.65700563804024 0.957745603726178 -0.149919175951797 0.300779966336596 0.894167310052 -0.357398048983414 "CDKN2C MUT" "GW.441756_IC_50" 0.539968776016866 0.861547651912703 0.265535021113244 0.657015730615015 0.957745603726178 0.188976831772701 0.889057746217505 0.988301482344111 0.064200924947274 "ERBB2 MUT" "MG.132_IC_50" 0.814022532768818 0.953913887475092 -0.250843754266212 0.657204692564 0.957745603726178 -0.430323759758435 0.886514019147027 0.988301482344111 -0.14785628153956 "EP300 MUT" "SB590885_IC_50" 0.42720663851378 0.819974531368247 1.02358195344126 0.657260724203844 0.957745603726178 0.480710987370776 0.398129180674539 0.916480913435499 0.946539443735493 "ERBB2 MUT" "Pyrimethamine_IC_50" 0.346491864141621 0.782020929432191 1.10099773037543 0.657367909555745 0.957745603726178 0.447418431287365 0.424704143795273 0.922428741067589 0.972531078560677 "KDM5C MUT" "Camptothecin_IC_50" 0.285501329969313 0.740302864659114 -1.6993613605313 0.657399154551752 0.957745603726178 -0.449065605128575 0.203611556329766 0.852959543285214 -1.77054689233011 "MS-HL MUT" "ABT.263_IC_50" 0.333557437827224 0.773264085106582 -0.286787830239209 0.657634566624196 0.957745603726178 -0.118410374716277 0.102884846573221 0.779624848478479 0.458592172329405 "SMO MUT" "VX.702_IC_50" 0.731585749569743 0.928176068595523 -0.364148874045806 0.657863933227571 0.957745603726178 -0.382288248331316 0.436083442237685 0.922569292988365 -0.765513917791062 "BRCA2 MUT" "AICAR_IC_50" 0.78956429226762 0.947425163069223 0.205675447470822 0.657909617423597 0.957745603726178 -0.307408113559581 0.7514476031135 0.968780465757047 0.236660650626406 "AKT2 MUT" "SL.0101.1_IC_50" 0.956934011238255 0.99327782426188 0.0269854609929074 0.658256051581395 0.957745603726178 -0.192372283825227 0.608619199544579 0.94989603148139 -0.247695257185331 "MLH1 MUT" "BI.D1870_IC_50" 0.824813977714552 0.957177484110155 0.108545565362931 0.658271923875766 0.957745603726178 0.18944335320149 0.523579376499226 0.940554660491705 0.299486098556071 "EGFR MUT" "PAC.1_IC_50" 0.966502773136717 0.994434372972651 0.0154253988384871 0.658285353351125 0.957745603726178 -0.136408603108786 0.61860059367388 0.950394619652337 -0.185397656227422 "FAM123B MUT" "Obatoclax.Mesylate_IC_50" 0.438753173518316 0.824054351147029 0.800822034965044 0.658336472581752 0.957745603726178 0.336124025810117 0.876662558011294 0.987838063957761 0.156161055696736 "MLH1 MUT" "X17.AAG_IC_50" 0.347664903492532 0.782672976989642 0.627830215820999 0.658349958611849 0.957745603726178 -0.264148591345394 0.601192037953708 0.949657634568742 0.309855545079654 "CDKN2A MUT" "NVP.TAE684_IC_50" 0.0534077966842645 0.413242516911974 -0.569787719819861 0.658425348304148 0.957745603726178 0.112312489215319 0.536403662826622 0.943443271455699 -0.211892978126886 "PDGFRA MUT" "NVP.BEZ235_IC_50" 0.412358741727917 0.812480994891775 -0.568362214 0.658436784953494 0.957745603726178 -0.221414801401939 0.959657743689637 0.99641548698706 -0.0338603129801775 "EGFR MUT" "Metformin_IC_50" 0.474834805076621 0.834555294653764 -0.21937529918209 0.658600337724982 0.957745603726178 -0.126963222436993 0.218310090207238 0.860928912580141 -0.387979427572322 "FBXW7 MUT" "NSC.87877_IC_50" 0.61209021450517 0.88496040166963 0.123368376623376 0.658722520057057 0.957745603726178 0.105923799420065 0.596004180888093 0.949294892873838 0.136082226864307 "EZH2 MUT" "PF.562271_IC_50" 0.97958745926158 0.996276778834563 -0.0149323893167695 0.65875526774955 0.957745603726178 -0.21005367984693 0.587133355496181 0.949294892873838 -0.335069391275749 "CDK4 MUT" "NVP.BEZ235_IC_50" 0.166879886810133 0.646299519579969 0.716780552643371 0.658807329485781 0.957745603726178 -0.165951978340259 0.167359649882081 0.84067330207935 0.718022644643496 "CDKN2A MUT" "SB590885_IC_50" 0.0462175954911366 0.382890359661179 -0.326448381350378 0.659048011308195 0.957832562702704 -0.0631050907687013 0.177789303320325 0.848722027112292 -0.220794943530087 "MET MUT" "JNK.Inhibitor.VIII_IC_50" 0.3195793616238 0.761442367303009 0.331921242718444 0.659254452144607 0.957832562702704 0.140739998321428 0.577638920243525 0.949294892873838 0.186888051404053 "AKT2 MUT" "Vinorelbine_IC_50" 0.180395229965096 0.658614416960816 -1.0306033304348 0.659300162675729 0.957832562702704 -0.248881587315118 0.361744528920505 0.91161229252998 -0.698188742327143 "CDKN2A MUT" "AICAR_IC_50" 0.864584926975812 0.967489995749939 -0.0257652307186222 0.659409449537809 0.957832562702704 0.0620912014755661 0.841132128842304 0.982150602679453 -0.0329848024638528 "BRCA2 MUT" "BMS.708163_IC_50" 0.824910090288455 0.957177484110155 0.120761624719103 0.659483333774651 0.957832562702704 0.245208460047534 0.803719888167 0.976660896667097 0.138657833726051 "PTEN MUT" "Elesclomol_IC_50" 0.110711552895994 0.559686423710509 -0.432521352834064 0.65951425750783 0.957832562702704 -0.101681310388363 0.626440081009866 0.951824526851774 -0.135632335509432 "PTEN MUT" "BI.D1870_IC_50" 0.494644781250357 0.843282996121548 -0.137774844102381 0.659828916413907 0.957978480991492 0.0783357634189017 0.575851246687454 0.949294892873838 -0.116728696546147 "PIK3CA MUT" "NVP.BEZ235_IC_50" 0.459804744570447 0.828966839128293 0.174663733206356 0.659830465963851 0.957978480991492 -0.0760371937289805 0.869872451007473 0.98753907730331 0.0402374801083915 "EP300 MUT" "Shikonin_IC_50" 0.758591608808584 0.934762260113025 -0.363897626942998 0.660172732285906 0.958168670619788 -0.440067406717938 0.971262254998246 0.99742775226181 -0.04139574262055 "FAM123B MUT" "Gemcitabine_IC_50" 0.502807976111068 0.846688971528705 1.21955726923078 0.660177243049486 0.958168670619788 -0.534184550397395 0.776715707183083 0.972337708041191 0.490191347762998 "FGFR2 MUT" "Mitomycin.C_IC_50" 0.00638548791385047 0.138397665983245 3.02258182547997 0.660573117362607 0.95858657766296 0.387180225412089 0.0612400862211375 0.702860976445846 2.32849630228145 "MYCL1 MUT" "CGP.082996_IC_50" 0.334406272289948 0.773264085106582 0.650722034482764 0.660809661383303 0.958763775714406 0.252104720867828 0.979827788755423 0.997827228172038 -0.0175821111103569 "MDM2 MUT" "Lenalidomide_IC_50" 0.876573110911368 0.971594429690931 0.0526368015414256 0.660942559359824 0.958763775714406 -0.130475701429865 0.867941244649194 0.987342922214615 0.0537352699053633 "NOTCH1 MUT" "BMS.536924_IC_50" 0.848426973243766 0.963170132861804 -0.139217185964913 0.661212899422942 0.958763775714406 -0.250207442676268 0.124955472036529 0.817150972850516 -1.219885830074 "CDKN2a(p14) MUT" "Sunitinib_IC_50" 0.00143296445396797 0.0555727393698231 -0.925137040000002 0.661325620620551 0.958763775714406 -0.102001137548471 0.0805071746013249 0.741811190933953 -0.50734249990784 "STK11 MUT" "Nutlin.3a_IC_50" 0.475604663259244 0.835134084317001 0.290001885809316 0.661396785955114 0.958763775714406 -0.163650520335393 0.999450452144791 0.999751228014461 0.000291344081402201 "MYC MUT" "Metformin_IC_50" 0.482936466444146 0.839032590911741 -0.164264030650573 0.661528837728826 0.958763775714406 -0.0959980405150868 0.532706710502595 0.943443271455699 -0.149830802688969 "FGFR3 MUT" "ABT.263_IC_50" 0.798129326033441 0.949524851900765 0.39422355664062 0.661558682771554 0.958763775714406 0.60742498853759 0.736245726757054 0.96672489654949 -0.449072421086315 "PIK3R1 MUT" "IPA.3_IC_50" 0.272628814322379 0.734000646544246 0.805811530755715 0.662136968585102 0.958763775714406 0.269593215711403 0.368309449273722 0.913948248824328 0.611678724406711 "KDM5C MUT" "Lenalidomide_IC_50" 0.978232669633652 0.996276778834563 0.0205193548387103 0.662145922312266 0.958763775714406 0.290343823214551 0.897272249987678 0.988301482344111 0.0923516124096653 "CDK4 MUT" "Shikonin_IC_50" 0.817209319466643 0.955165737441734 0.168324371080141 0.662188050953338 0.958763775714406 0.269056290990498 0.667274265511687 0.959230524020512 0.324179145630296 "EZH2 MUT" "PLX4720_IC_50" 0.533963183425287 0.858279561609675 -0.528226657692313 0.662224738338349 0.958763775714406 -0.327551766866125 0.830636816020739 0.981482581683432 -0.164265124795489 "MET MUT" "Axitinib_IC_50" 0.153006182249296 0.626774863725089 0.741356435203097 0.662238392747092 0.958763775714406 0.191940297769245 0.604919181998159 0.949657634568742 0.23569648984724 "SETD2 MUT" "MK.2206_IC_50" 0.590015079397346 0.876506729771444 -0.68155106804122 0.662285410349307 0.958763775714406 0.443395740121671 0.621528185230439 0.950496524771391 -0.609566226606546 "FGFR3 MUT" "ABT.888_IC_50" 0.76728505608996 0.938086258691483 0.22164614476191 0.662485314792097 0.958763775714406 0.275704719644335 0.832914107345321 0.981482581683432 -0.147384906036932 "MYCN MUT" "WZ.1.84_IC_50" 0.0702206364755646 0.469247157667035 0.684866046753247 0.662755437509329 0.958763775714406 0.143963518992665 0.335576135178589 0.905301232236042 -0.417981817365855 "MAP2K4 MUT" "Bexarotene_IC_50" 0.794881386378341 0.948646027682356 -0.117139491680304 0.662757745382083 0.958763775714406 0.175093152975858 0.519181412700984 0.939635632721979 -0.304978343504875 "CTNNB1 MUT" "BX.795_IC_50" 0.493843948295646 0.843282996121548 -0.319351121212121 0.662850432551807 0.958763775714406 -0.157185635130568 0.0141444069312799 0.486885573475568 -1.102676258188 "FLCN MUT" "PF.4708671_IC_50" 0.746796224303694 0.931110103613801 0.219751947565546 0.662880086666882 0.958763775714406 0.293038967548609 0.688544952487739 0.961100601384891 0.338144022435911 "RB1 MUT" "Epothilone.B_IC_50" 0.484930892916367 0.83972091053812 0.21318508379292 0.662942140078757 0.958763775714406 0.0776924829015595 0.695240682626419 0.961100601384891 -0.132429606843204 "CCND3 MUT" "AICAR_IC_50" 0.483711068020385 0.839194763643102 0.850752417794989 0.66318882280131 0.958763775714406 0.473077887243615 0.575833791086906 0.949294892873838 0.649406418481275 "EP300 MUT" "OSI.906_IC_50" 0.55475841928866 0.867243358863332 0.696787051103361 0.663332626243294 0.958763775714406 0.487587581715437 0.700045277654534 0.961100601384891 0.454073386153588 "BRCA2 MUT" "WH.4.023_IC_50" 0.544069199308116 0.862633715268747 1.52809240136055 0.663471944136888 0.958763775714406 -0.961448900050716 0.631335984588887 0.952523560833852 1.14416957081566 "FLCN MUT" "MS.275_IC_50" 0.900164348932275 0.97933285041609 0.159703665525113 0.663640788903061 0.958763775714406 -0.458311476154609 0.831582503887362 0.981482581683432 -0.496421072222422 "STK11 MUT" "AZD7762_IC_50" 0.501024464923561 0.846334637471348 0.261883144554454 0.663675482435277 0.958763775714406 -0.132370821724288 0.700163508176161 0.961100601384891 0.145817995981171 "NF2 MUT" "AMG.706_IC_50" 0.499557002017828 0.845156823715784 0.192882093113105 0.663791318917077 0.958763775714406 0.115361294146694 0.385133022641573 0.915331032347709 0.244271559499895 "CDH1 MUT" "Roscovitine_IC_50" 0.427648005165115 0.820644324518449 -0.598131707317076 0.664047258845977 0.958763775714406 -0.296401013121419 0.790394173236275 0.975393509832241 -0.205852455398013 "MLL_AFF1 MUT" "IPA.3_IC_50" 0.070520070202267 0.469481816691404 -2.64063889391307 0.664050415231806 0.958763775714406 -0.542422628027215 0.565891260662629 0.949294892873838 -0.785076991986256 "CTNNB1 MUT" "Nilotinib_IC_50" 0.786844531801468 0.946449577332088 -0.124415147734047 0.664380531128965 0.958763775714406 -0.162320443709611 0.752756847264304 0.968780465757047 -0.142362968307029 "CCND3 MUT" "CCT018159_IC_50" 0.642117222543612 0.896094514063559 -0.465864611872149 0.664420345458552 0.958763775714406 -0.404305379390105 0.729336039418855 0.965574102111877 -0.347842742696662 "HRAS MUT" "Gemcitabine_IC_50" 0.363889100179131 0.787306955898826 1.65227297202796 0.664432709509501 0.958763775714406 0.530046809070419 0.191724927037499 0.851001889249827 2.22558827481042 "RB1 MUT" "CGP.60474_IC_50" 0.894198614309542 0.976198880600252 0.0408033492048902 0.664506111350468 0.958763775714406 0.102117104330638 0.161865690613932 0.839927262232576 -0.489040590444991 "IDH1 MUT" "Pazopanib_IC_50" 0.715576211564211 0.920719574063407 -0.486297994782613 0.664527425750018 0.958763775714406 -0.489812804047052 0.621829440688262 0.950496524771391 0.604858180300977 "IDH1 MUT" "Embelin_IC_50" 0.385165439065317 0.798746759187088 -0.880366539130442 0.664627599583447 0.958763775714406 -0.349136379343234 0.587719290738699 0.949294892873838 -0.547053765433848 "EP300 MUT" "ZM.447439_IC_50" 0.580134073685367 0.875177630100178 -0.511873093933471 0.664666601534401 0.958763775714406 -0.320351218588339 0.4472637032271 0.925809648901546 -0.660123973998508 "AKT2 MUT" "Methotrexate_IC_50" 0.712836486211389 0.919646314953749 0.366472413306456 0.66480331220394 0.958763775714406 -0.32870797058719 0.979427785341208 0.997827228172038 -0.0205613207811178 "KDM6A MUT" "CCT018159_IC_50" 0.887276638603318 0.975214727041194 -0.0564534498288595 0.664919013712098 0.958763775714406 0.16083486051297 0.962062115576062 0.996625877572729 0.0191662994392346 "CDKN2C MUT" "PLX4720_IC_50" 0.506566371092416 0.847796212975596 0.447231529013542 0.664981161856089 0.958763775714406 0.260071645252955 0.189878226160894 0.851001889249827 0.856344182396037 "GNAS MUT" "NVP.BEZ235_IC_50" 0.450957209797229 0.828077050034054 0.414458310865195 0.665087258052681 0.958763775714406 -0.171574795402031 0.923424277160513 0.993931766508607 -0.0501061529944172 "FGFR2 MUT" "GW.441756_IC_50" 0.774677240391695 0.941591338606299 0.246676984819733 0.665257547535685 0.958763775714406 0.367512464720732 0.894123294477386 0.988301482344111 0.160457124142725 "KDR MUT" "EHT.1864_IC_50" 0.613197042387588 0.885064673077226 -0.370342505592843 0.665277025303749 0.958763775714406 -0.315763110752169 0.58853767207183 0.949294892873838 -0.389564170217813 "FLT3 MUT" "PLX4720_IC_50" 0.844292808019159 0.960498931426639 0.214965781609196 0.665297095741162 0.958763775714406 0.424733481228362 0.681012573515867 0.961100601384891 0.40987445966827 "MAP2K4 MUT" "SB590885_IC_50" 0.859511718023418 0.966322414954601 -0.0941396315426993 0.665355351412859 0.958763775714406 -0.192664621469434 0.253328105857753 0.875707386589409 0.588281261466086 "BCR_ABL MUT" "AZ628_IC_50" 0.00302176829980411 0.0871309229563645 -3.99824872945211 0.665430404108733 0.958763775714406 -0.555520902207077 0.00736237712436356 0.383871009534609 -3.17384717592434 "FLCN MUT" "X681640_IC_50" 0.926052644691716 0.98643792569589 0.0759934969450102 0.665445322993311 0.958763775714406 -0.302215364527736 0.30512587300229 0.896105449118166 -1.11019598519166 "RB1 MUT" "Sunitinib_IC_50" 0.61069157666408 0.884818029552257 0.197924330453166 0.665804400383541 0.958844941341602 0.128252530218905 0.146255405437413 0.831473272394224 -0.57780418854131 "GNAS MUT" "ATRA_IC_50" 0.414853025884079 0.814032033933559 0.500967432432434 0.665831590520618 0.958844941341602 -0.208682232227873 0.648696187765213 0.957493413330814 0.24514531396699 "MDM2 MUT" "A.443654_IC_50" 0.683260240241032 0.910296158652956 -0.373175553264606 0.665860958135905 0.958844941341602 0.256454002061707 0.955390514821011 0.996100446818628 0.0523114758302363 "BCR_ABL MUT" "NSC.87877_IC_50" 0.355136077806234 0.785252181551816 0.519164013840826 0.665998844798272 0.958844941341602 0.285534197736418 0.496469082295348 0.933676180352967 0.394996323497347 "FAM123B MUT" "PAC.1_IC_50" 0.722759647192702 0.923705342742609 0.275044444055946 0.666134042411631 0.958844941341602 0.280186266159762 0.766640496728433 0.969901216545994 0.224922503159441 "MSH2 MUT" "NVP.BEZ235_IC_50" 0.449983408713657 0.827950185889909 -0.443581664945501 0.666149452547876 0.958844941341602 -0.183053403151874 0.215984164776621 0.860576337437605 -0.694940812297487 "CDKN2A MUT" "GW.441756_IC_50" 0.718757054365106 0.92132587844031 -0.0382273432487695 0.666433764151177 0.958862241808704 0.0462646782289348 0.502434152499013 0.934042323734638 0.0802674203354856 "NF1 MUT" "X17.AAG_IC_50" 0.560473604987253 0.870039293305752 0.272394178398897 0.66674878736406 0.958862241808704 0.178303675442967 0.612011131074284 0.949930222127033 -0.225968894524202 "VHL MUT" "GW843682X_IC_50" 0.166941909460247 0.646299519579969 1.51775529794521 0.666774742810759 0.958862241808704 0.249517947088855 0.209957542363629 0.854552215275616 1.66932165011064 "BRAF MUT" "QS11_IC_50" 0.296971694432281 0.748200175390948 -0.289830287182165 0.666817224101067 0.958862241808704 0.0968221441068744 0.109715720785678 0.796066434883663 -0.5186938448927 "NOTCH1 MUT" "AICAR_IC_50" 0.00234521709103083 0.0738577056221447 -1.45919147157189 0.666819569087157 0.958862241808704 -0.19273111448321 0.311872934811665 0.898149383211927 -0.506405011433787 "GNAS MUT" "Temsirolimus_IC_50" 0.377317889002847 0.795261485512158 0.717042771593085 0.666901261534333 0.958862241808704 -0.266592300790586 0.97219268819093 0.99742775226181 0.0268477687471569 "MSH2 MUT" "AZD.0530_IC_50" 0.448884570882326 0.827360921900611 0.631176294653019 0.666972036697919 0.958862241808704 0.311807591590616 0.589529591201306 0.949294892873838 0.431948145641889 "MYC MUT" "ZM.447439_IC_50" 0.810148329175618 0.952739326074327 -0.0632163154008434 0.667105207196869 0.958862241808704 -0.0902586567817452 0.870303424496679 0.98753907730331 -0.0424855040894126 "MAP2K4 MUT" "WO2009093972_IC_50" 0.785520755756768 0.946055035513406 -0.134202122065725 0.667156925983172 0.958862241808704 -0.189416433164204 0.208443868127122 0.853446327418758 -0.649935935050151 "CDKN2C MUT" "Imatinib_IC_50" 0.530077435358183 0.856734402332693 0.360042582480091 0.667398771451597 0.958862241808704 0.243301708728726 0.372523219163323 0.913948248824328 0.656010709495379 "TET2 MUT" "PAC.1_IC_50" 0.266340686916061 0.729152786837712 -1.11001761207897 0.667737305385912 0.958862241808704 -0.363904051314056 0.582854273979965 0.949294892873838 0.648314618167436 "PIK3R1 MUT" "NVP.TAE684_IC_50" 0.317994569595556 0.761258739353268 1.10471753898305 0.667738131671268 0.958862241808704 0.388878908145596 0.249992912577885 0.875707386589409 1.26422598653415 "MLL_AFF1 MUT" "Bryostatin.1_IC_50" 0.44765112722873 0.826231147407263 0.677899497391312 0.667936527418524 0.958862241808704 0.367254919894558 0.885738436742602 0.988301482344111 0.123395896246634 "KDM5C MUT" "BMS.509744_IC_50" 0.732540868387265 0.928191675295662 -0.297982610921503 0.667983639886819 0.958862241808704 0.279130574698996 0.622851232832324 0.950496524771391 -0.419636277935427 "CDK4 MUT" "MK.2206_IC_50" 0.363654411191553 0.787306955898826 0.545479755462575 0.668075348906705 0.958862241808704 -0.206112903106926 0.603578745644004 0.949657634568742 0.321289845565149 "EWS_FLI1 MUT" "CCT007093_IC_50" 0.408668154229103 0.810304102803978 -0.235208607639502 0.668132131732788 0.958862241808704 -0.1360770301702 0.903095861311653 0.988746233284632 -0.0454007541263651 "MSH6 MUT" "Gemcitabine_IC_50" 0.489493800470699 0.842479543019433 -0.9970180417399 0.668257383453931 0.958862241808704 0.414160758381246 0.548488061716418 0.947060194029534 -0.805711777271936 "TSC1 MUT" "GDC0941_IC_50" 0.392228901952654 0.803073858340542 1.10065837577004 0.668334878858185 0.958862241808704 0.44512232520029 0.224607688538187 0.86643108387559 1.55095462287165 "MLH1 MUT" "PHA.665752_IC_50" 0.945104934707991 0.990147156460271 0.0338144863013696 0.668367875313779 0.958862241808704 -0.211525174580309 0.898444506522321 0.988526046030225 0.0650814913409728 "CDK6 MUT" "Temsirolimus_IC_50" 0.270397240844222 0.733000988154624 0.8445975818376 0.668410241170528 0.958862241808704 0.250556696959634 0.552883797325811 0.947568031460906 0.431241856342564 "APC MUT" "Imatinib_IC_50" 0.366806429908414 0.788882799008227 0.385361493055557 0.668428796198365 0.958862241808704 0.186499969891768 0.447269466137482 0.925809648901546 0.405626676900627 "CDKN2a(p14) MUT" "BMS.708163_IC_50" 0.444385313429813 0.825606373270691 0.0893826994372174 0.668768914196048 0.958944590304898 0.0520331349809204 0.464244154293701 0.929276781658587 0.0963809323052143 "CCND1 MUT" "KU.55933_IC_50" 0.726172063935741 0.92547791524492 -0.090153842975206 0.668785179659876 0.958944590304898 -0.098625689624477 0.669350737092098 0.959230524020512 -0.117087147305941 "BRCA2 MUT" "Sorafenib_IC_50" 0.281857450704416 0.738375640008268 1.41132763050846 0.668810133132365 0.958944590304898 0.536383475465929 0.262228391893105 0.877052916121269 1.53752807831179 "BRCA1 MUT" "CCT007093_IC_50" 0.972709217282909 0.995463304757952 -0.0173855381165917 0.668922087689552 0.958950292295547 -0.218286743624844 0.932262262494179 0.994235539701634 0.0435466140156544 "FLCN MUT" "LFM.A13_IC_50" 0.909449053343973 0.981529929795606 0.0564988111888111 0.669359611527192 0.959422645250644 -0.199368557964322 0.996097897997858 0.999545005862799 -0.00310905606692059 "AKT2 MUT" "ABT.888_IC_50" 0.980334967971353 0.996332002460735 -0.0107001740243127 0.669694347127713 0.959655681932596 -0.156206549037561 0.500043642809113 0.934042323734638 -0.276049854396005 "FGFR2 MUT" "PAC.1_IC_50" 0.10949459821597 0.557261619917495 1.384570452007 0.669989811129261 0.959655681932596 0.314924707502567 0.402303749019565 0.916823093416154 0.805991358001789 "MET MUT" "AS601245_IC_50" 0.651589318093809 0.899243470992269 -0.247604091230326 0.670156539345108 0.959655681932596 0.187508344559398 0.828803828810613 0.981081757090089 -0.117471137134115 "MDM2 MUT" "Vinorelbine_IC_50" 0.173268942881924 0.65113493295882 0.878850770979022 0.670179473526931 0.959655681932596 0.201522746050163 0.133842105880884 0.827361946088783 0.947344542085683 "EZH2 MUT" "Epothilone.B_IC_50" 0.609613182461144 0.884443710620525 0.453208364411033 0.670280059466055 0.959655681932596 0.215039863798354 0.979640533312189 0.997827228172038 -0.0237951707218441 "MAP2K4 MUT" "BI.2536_IC_50" 0.268922824024859 0.732006752858616 1.45355687755102 0.670295549431096 0.959655681932596 0.331945646424164 0.093145465363651 0.768046723169691 2.78199120350215 "ALK MUT" "Nutlin.3a_IC_50" 0.587963468534265 0.876506729771444 -0.585292812785392 0.670305522367601 0.959655681932596 0.423069739150012 0.614886832889235 0.950059945073224 -0.647342394404578 "EZH2 MUT" "Cyclopamine_IC_50" 0.331770650535858 0.772603259108552 0.721766206896555 0.67050381382136 0.959655681932596 0.289942295705269 0.0658111646399554 0.711992560878964 1.56847269232516 "ALK MUT" "Paclitaxel_IC_50" 0.257881096540631 0.722245984981816 1.481797778157 0.670735688863316 0.959655681932596 0.244031457570695 0.628312228971653 0.952175822853038 0.741074664747523 "MYC MUT" "BIRB.0796_IC_50" 0.950243109466869 0.991669689209784 -0.0124804979466109 0.670808354206966 0.959655681932596 -0.0817643683633672 0.566926151101017 0.949294892873838 0.118534431310354 "NF2 MUT" "SB.216763_IC_50" 0.957056146133823 0.99327782426188 -0.0174602361673423 0.670968865478185 0.959655681932596 -0.133864273481881 0.747583293835892 0.968780465757047 -0.107656412745505 "PDGFRA MUT" "Thapsigargin_IC_50" 0.438548745205187 0.824054351147029 -1.00099232517483 0.670979448725619 0.959655681932596 -0.418792073151784 0.837728784059153 0.981704379975756 -0.261454236883535 "RUNX1 MUT" "PF.562271_IC_50" 0.549490540791017 0.864873049004332 0.412524088388211 0.671030023295564 0.959655681932596 0.23811726936899 0.954221110165883 0.99568364368633 0.0431700558025357 "MSH6 MUT" "AKT.inhibitor.VIII_IC_50" 0.612516744037124 0.88496040166963 -0.288716456445993 0.671079245722376 0.959655681932596 -0.207259264299938 0.594400493734393 0.949294892873838 -0.294671820818535 "CCND1 MUT" "AZD.0530_IC_50" 0.920158218748204 0.986016435821543 -0.0597169506387922 0.67122432809997 0.959655681932596 -0.222455080380002 0.474699185880523 0.929844139269115 0.466668910232696 "KDR MUT" "AICAR_IC_50" 0.674588565923373 0.908418658675584 -0.416902519379845 0.671286994751333 0.959655681932596 -0.377296088612751 0.261322256105839 0.877052916121269 -1.08172533778159 "SMO MUT" "Elesclomol_IC_50" 0.752324845556331 0.933649480870792 0.486957796963945 0.671528481406583 0.959655681932596 -0.541336314996755 0.851491490765217 0.984550422117456 0.271782962273166 "BRCA1 MUT" "BMS.509744_IC_50" 0.905608703397047 0.980938028402143 0.145737016949152 0.671564530869972 0.959655681932596 0.386110315290014 0.947030581326671 0.995668765770473 -0.0813102814875418 "HRAS MUT" "PLX4720_IC_50" 0.959484700395302 0.993456347206305 -0.0394298882466278 0.6715752801724 0.959655681932596 -0.293110672017574 0.650600542169303 0.957867556929346 0.318563275715242 "MLH1 MUT" "Parthenolide_IC_50" 0.417274718602841 0.814099702076568 0.463236658075603 0.671794066659247 0.959813884491759 0.227497120020807 0.45746021563371 0.925866949645164 0.44246554481937 "CCND3 MUT" "Embelin_IC_50" 0.525458108193148 0.854969048950887 0.456021317626538 0.672033365652237 0.959963397978555 0.242984054332964 0.362170663337005 0.91161229252998 0.647702531398995 "RB1 MUT" "Midostaurin_IC_50" 0.19822532782643 0.674012093366938 0.308048436731929 0.672327251472363 0.959963397978555 0.0800777184350996 0.921042991705695 0.993931766508607 0.0246314408107695 "ALK MUT" "Lenalidomide_IC_50" 0.607890752350724 0.884017916530788 -0.385816888045539 0.672371184874545 0.959963397978555 -0.279796137530254 0.550202662597538 0.947060194029534 -0.433294171412985 "SMARCA4 MUT" "GSK.650394_IC_50" 0.855736722092393 0.96514911547635 0.115182357532928 0.672460425706579 0.959963397978555 -0.172319721013353 0.864789460635228 0.987077901072027 -0.120700681255369 "NOTCH1 MUT" "Etoposide_IC_50" 0.00160914368304617 0.0592029235061749 -1.95012407729679 0.67249546941085 0.959963397978555 -0.177818507079898 0.0620771073849403 0.702860976445846 -1.20749405445112 "AKT2 MUT" "BI.D1870_IC_50" 0.347668606488474 0.782672976989642 0.62028807229687 0.672547265197902 0.959963397978555 0.240959641225419 0.665370020745601 0.959206771190239 0.273060175655127 "CTNNB1 MUT" "IPA.3_IC_50" 0.929460058680948 0.986689293492114 0.0478069145907481 0.672866639877497 0.960246579447761 0.191169291309203 0.262699615336676 0.877052916121269 0.631106072004694 "JAK2 MUT" "Lenalidomide_IC_50" 0.929408234205543 0.986689293492114 -0.0357817049808435 0.672976012277501 0.960246579447761 -0.149734506869828 0.961996526715977 0.996625877572729 -0.0200884135982533 "PDGFRA MUT" "Epothilone.B_IC_50" 0.810918846639158 0.952889749533063 -0.250825937062934 0.673138294806677 0.960246579447761 0.252106912698201 0.759620448589323 0.969901216545994 -0.318096570398551 "FGFR2 MUT" "GSK.650394_IC_50" 0.00310302624813353 0.0888966971279802 3.07636082547996 0.673392397099986 0.960246579447761 -0.288976132619777 0.0254287531810119 0.578483940084869 2.67170565484728 "FGFR3 MUT" "FH535_IC_50" 0.906495106591024 0.981251818741413 -0.108098611498257 0.673517973709563 0.960246579447761 0.332077321907915 0.81697247987474 0.977383317127464 -0.203318301891436 "KIT MUT" "FH535_IC_50" 0.297783124511546 0.748701828501963 -0.743178596153851 0.673656401874108 0.960246579447761 -0.258437806842871 0.66139052441582 0.958689538788368 -0.3000210107151 "KIT MUT" "PD.0332991_IC_50" 0.950735604473977 0.991950529057024 0.0611394958592126 0.673725135111653 0.960246579447761 0.333221547843912 0.854552764186196 0.984631915507353 0.17129609255854 "BRCA1 MUT" "Rapamycin_IC_50" 0.954464525895579 0.992679871625456 0.122216104026845 0.673748205695403 0.960246579447761 -0.772182295129687 0.957747001778293 0.99641548698706 0.116462046909262 "CCND3 MUT" "Temsirolimus_IC_50" 0.473562962412764 0.834460661638643 1.1576859089184 0.673895378170667 0.960246579447761 0.517870298443 0.493051178092869 0.933639405738697 1.04570064856192 "KDR MUT" "AZD6244_IC_50" 0.49213622685015 0.842990705166559 0.891050999999991 0.673936093640095 0.960246579447761 0.496535844279982 0.531776058150275 0.94320946427311 0.733401924207089 "CCND2 MUT" "Embelin_IC_50" 0.971811639623374 0.995220468612913 -0.029283931475029 0.674016826907739 0.960246579447761 -0.276782689232576 0.300033850248352 0.894167310052 -1.03737643491254 "EWS_FLI1 MUT" "AS601245_IC_50" 0.906969357598135 0.981251818741413 0.0550740593119815 0.674122103080115 0.960246579447761 0.167211775230049 0.560749197806141 0.949294892873838 0.309519778174617 "STK11 MUT" "WO2009093972_IC_50" 0.959568240772141 0.993456347206305 -0.0164103292880269 0.674151269322913 0.960246579447761 -0.121670600043366 0.810318216810378 0.977383317127464 -0.0818659201258235 "TET2 MUT" "MK.2206_IC_50" 0.0994483706504144 0.5374999166548 -1.70119171074375 0.674936897125032 0.960598223398966 -0.350616734786943 0.607904926531167 0.949657634568742 -0.636036226422781 "TET2 MUT" "Sunitinib_IC_50" 0.342082264050725 0.778783026668672 -1.29873398065983 0.675059130176717 0.960598223398966 0.427733367356055 0.573237902241911 0.949294892873838 -0.821558699943348 "MLH1 MUT" "PAC.1_IC_50" 0.0990880841553134 0.5374999166548 -0.829521282448385 0.675194777042608 0.960598223398966 0.179280859485544 0.426457505429807 0.922428741067589 -0.388600128682197 "KDM6A MUT" "A.443654_IC_50" 0.0850366562157287 0.503473695901258 -0.895509057142852 0.675325672407166 0.960598223398966 -0.142262235936156 0.180965970917335 0.848722027112292 -0.774128123222555 "MLL_AFF1 MUT" "Vorinostat_IC_50" 0.0899771135131896 0.514353900587832 -1.51843806692914 0.675409972081668 0.960598223398966 -0.29156273576903 0.923971445452312 0.993978204254811 -0.0789112598035676 "NF2 MUT" "NVP.BEZ235_IC_50" 0.17529908346693 0.653581511448282 -0.46578808018497 0.675484134595061 0.960598223398966 -0.104922397189281 0.888354320679373 0.988301482344111 -0.0489910405875202 "BCR_ABL MUT" "Sorafenib_IC_50" 0.00122500072578317 0.0508375301200014 -2.98471950170646 0.675679814382484 0.960598223398966 -0.483913691545622 0.0110102942608403 0.450437967177441 -2.46548839562364 "PDGFRA MUT" "AZD6482_IC_50" 0.184433471394664 0.660385845878234 -1.17129325303292 0.67570708817701 0.960598223398966 -0.311703844432624 0.655539561080996 0.958313128388245 -0.390751687186215 "VHL MUT" "Temsirolimus_IC_50" 0.80933906092212 0.952641225877339 -0.196031789347405 0.675719098731842 0.960598223398966 0.262665761586575 0.68825491044411 0.961100601384891 -0.335472546576637 "HRAS MUT" "BX.795_IC_50" 0.317268252430807 0.761258739353268 -0.717775861507138 0.675784070484024 0.960598223398966 -0.232702017506276 0.485698530131364 0.933639405738697 -0.439884449317309 "BCR_ABL MUT" "GDC0941_IC_50" 0.852270329779839 0.964196154467744 0.195875059670781 0.675871180568122 0.960598223398966 0.453543551373836 0.214186686379236 0.859434499119166 1.33340801282846 "MLL_AFF1 MUT" "AZ628_IC_50" 0.835683262533353 0.959122768755193 -0.397081323129252 0.675969150199014 0.960598223398966 -0.607136052643479 0.73219799034977 0.966676227971091 0.56789448592244 "KIT MUT" "Doxorubicin_IC_50" 0.303117495054437 0.752792638025294 -0.901546421328678 0.675976340197953 0.960598223398966 -0.229430407517852 0.299002132398234 0.894167310052 -0.86723833603895 "KDM5C MUT" "NSC.87877_IC_50" 0.711455110119988 0.919312211985394 0.207748702422149 0.676076682351701 0.960598223398966 0.230836857590891 0.826694264526999 0.980698467734194 0.124370287771001 "RUNX1 MUT" "JNK.9L_IC_50" 0.324214069291828 0.765579672794663 0.60791490363951 0.67608020608619 0.960598223398966 0.201178847314606 0.549275935160385 0.947060194029534 -0.407069684167898 "VHL MUT" "AZD6244_IC_50" 0.732222909763511 0.928176068595523 0.27326976043841 0.676130180743141 0.960598223398966 0.305453045782946 0.733534104326598 0.96672489654949 -0.263909457173062 "MSH6 MUT" "BMS.708163_IC_50" 0.588749477032436 0.876506729771444 -0.329534365470858 0.676367954372321 0.960598223398966 -0.255857532298594 0.59217076080569 0.949294892873838 -0.329674777036483 "MDM2 MUT" "QS11_IC_50" 0.333180932319055 0.773185226006147 0.60518314109347 0.676378326689007 0.960598223398966 -0.191726203211396 0.46804725015572 0.929276781658587 0.441546198074997 "SMARCB1 MUT" "Obatoclax.Mesylate_IC_50" 0.91782759563788 0.985161575641771 -0.168316918260871 0.676453247284893 0.960598223398966 0.49838192575704 0.969852251263569 0.997173634484198 -0.0598923357213098 "MLLT3 MUT" "KIN001.135_IC_50" 0.745043681262346 0.930361773522342 -0.0812807958477505 0.676940268031586 0.961012265358674 -0.101098912306165 0.448800958897264 0.925809648901546 -0.187539880212947 "CDH1 MUT" "Midostaurin_IC_50" 0.125379308686349 0.586857535554275 0.961048593949977 0.676961235455902 0.961012265358674 0.20426142290932 0.211488915430592 0.855272470862467 0.763013232161705 "MLH1 MUT" "Gefitinib_IC_50" 0.134868573539433 0.601893367640051 -0.738929969989465 0.67733295354286 0.961386281031507 -0.187605011282763 0.208794196605797 0.853446327418758 -0.564659318881298 "MYCL1 MUT" "NU.7441_IC_50" 0.866590935067523 0.967996000759365 -0.0987044552683902 0.677476027874175 0.96143569887353 -0.213777397771463 0.664034660197471 0.959206771190239 0.273170847119031 "CDKN2a(p14) MUT" "FH535_IC_50" 0.0970260500201255 0.53125052418541 -0.228719897649823 0.677605426366832 0.961465696047904 0.0515039844152825 0.693261111832976 0.961100601384891 0.0581451846256003 "CCND2 MUT" "CCT018159_IC_50" 0.786965786707841 0.946449577332088 -0.270928538812786 0.677876661165855 0.961502248637111 -0.384882469714713 0.509129151942478 0.938147991955214 -0.667821236841376 "CDK4 MUT" "AZD6244_IC_50" 0.364921040231147 0.787611719688425 0.682670284983727 0.677897564527696 0.961502248637111 0.285482661494214 0.287812892188281 0.888563331668781 0.755738858045451 "TSC1 MUT" "BMS.754807_IC_50" 0.245937858799852 0.714668105985286 1.89094682260871 0.677982315632208 0.961502248637111 0.56563913413732 0.27692589611879 0.884350551395532 1.73308956811259 "RUNX1 MUT" "DMOG_IC_50" 0.397376221596436 0.805546273453081 0.680174835355279 0.678064247631373 0.961502248637111 0.299161139546131 0.654652383839049 0.958313128388245 0.376907130574326 "CCND1 MUT" "DMOG_IC_50" 0.657820792660227 0.901751651084414 0.156227987987989 0.678182158669704 0.961514055716158 -0.132621470091893 0.754220016566992 0.969352817240442 -0.111721556278123 "EP300 MUT" "Lapatinib_IC_50" 0.479526957644132 0.836304203722611 -0.893285758620681 0.678289106976887 0.961514055716158 0.452968604986615 0.850512769837233 0.984453468864253 -0.209077541360905 "FLT3 MUT" "Nutlin.3a_IC_50" 0.876117033566393 0.971594429690931 -0.168433112850623 0.67842227375649 0.961549347786688 -0.414905218856533 0.654740185591864 0.958313128388245 0.469630272309292 "STK11 MUT" "Pyrimethamine_IC_50" 0.814360697957483 0.954008357546551 0.246209417808217 0.678573049018113 0.961609581670633 -0.368176046131807 0.788303870621898 0.975265472692061 0.321797807112788 "MYCL1 MUT" "AZD6482_IC_50" 0.520390089266673 0.852599738673405 0.403075092657339 0.678981180213118 0.961860692660822 0.21904959639805 0.925613245263881 0.994026707431102 -0.0624658263526482 "NF1 MUT" "KU.55933_IC_50" 0.167927622684379 0.647446641789 0.368978341384861 0.679148478385113 0.961860692660822 0.099051683078378 0.489838127779457 0.933639405738697 0.197623839322381 "STK11 MUT" "Tipifarnib_IC_50" 0.224151091303155 0.696139064632428 0.567043490430986 0.679159101023777 0.961860692660822 0.128562134410919 0.24375199297201 0.875707386589409 0.569420372235585 "CCND3 MUT" "KU.55933_IC_50" 0.533527669883904 0.858279561609675 0.553589349112423 0.679183470743837 0.961860692660822 0.326910972460345 0.432133910413862 0.922569292988365 0.684831447193665 "BRCA2 MUT" "LFM.A13_IC_50" 0.945242850035786 0.990147156460271 0.0311733800350263 0.679418238590437 0.962039760351032 -0.177603452743097 0.690701431536729 0.961100601384891 -0.181560993377266 "SMARCA4 MUT" "CEP.701_IC_50" 0.943700425821391 0.990147156460271 -0.0416324535645473 0.679562541958434 0.96209069586049 -0.177733988321224 0.814860706693374 0.977383317127464 -0.14281283094688 "FLCN MUT" "Vinblastine_IC_50" 0.602316127890988 0.880745626033854 -0.467161537142858 0.679743652166477 0.962190450932908 -0.267623904663455 0.892069669061689 0.988301482344111 0.160969452930159 "EZH2 MUT" "SB.216763_IC_50" 0.6408859120563 0.896000211845268 -0.305036450980389 0.679849688053597 0.962190450932908 -0.259271269037262 0.553517159832328 0.947712723437614 -0.37297752248864 "PIK3CA MUT" "SB.216763_IC_50" 0.235582730220782 0.708702464036204 0.254467508029077 0.680044573511921 0.962312915449231 0.0861563353384989 0.252440311427081 0.875707386589409 0.261719569512943 "PTEN MUT" "Etoposide_IC_50" 0.684273300844496 0.910689522673456 -0.115774362661095 0.680276771148031 0.962356682857149 0.0777137489414577 0.549207620925408 0.947060194029534 -0.175843776917766 "SETD2 MUT" "Shikonin_IC_50" 0.451836014303328 0.828509891052426 1.08988343793106 0.68042500700201 0.962356682857149 0.505129579202832 0.382289110676505 0.915134825237766 1.23564029471096 "AKT2 MUT" "RO.3306_IC_50" 0.437245228640147 0.823808548892323 0.513000157170922 0.68043145454917 0.962356682857149 0.259359705515418 0.395365601024747 0.916003810456352 0.565972102298535 "MLL_AFF1 MUT" "AZD7762_IC_50" 0.262766953320387 0.724847082936025 -1.41721879809527 0.680508948130041 0.962356682857149 0.414079640290367 0.711060084818169 0.962630898212352 0.431905627481635 "CDKN2C MUT" "A.770041_IC_50" 0.732424038815159 0.928176068595523 0.360568292096222 0.680661533296531 0.962419213056279 0.353306373143155 0.437942093299794 0.922569292988365 0.943552404249149 "CDK6 MUT" "Paclitaxel_IC_50" 0.593980349984776 0.878468193610776 0.805478721088435 0.680844277601398 0.962524359977398 -0.27030595129099 0.752940475377945 0.968780465757047 0.581395501908326 "CTNNB1 MUT" "AS601245_IC_50" 0.480751031493428 0.837166649155517 -0.33222312502966 0.681159513663726 0.962668007342713 0.15471921429842 0.623097586751275 0.950496524771391 0.257188468329848 "APC MUT" "GW.441756_IC_50" 0.31116276938014 0.758106606660947 0.227935519562119 0.681162679669138 0.962668007342713 0.0953738800320891 0.311141875595672 0.898149383211927 0.277770173546893 "TET2 MUT" "KU.55933_IC_50" 0.0855390436199732 0.503679085433888 -1.2478740447958 0.681360528591133 0.962794408021934 -0.270130496999213 0.809597507213314 0.977383317127464 -0.2130114009477 "JAK2 MUT" "Z.LLNle.CHO_IC_50" 0.95381557579189 0.992679871625456 -0.0610171888509673 0.681811727552559 0.963201691897013 -0.393987407262806 0.162053011272926 0.839927262232576 1.76735611501849 "MDM2 MUT" "GSK269962A_IC_50" 0.891069053767202 0.975972789421281 0.142797465068494 0.682156267179679 0.963201691897013 0.398773256739511 0.829064961100953 0.981081757090089 0.224424094464145 "MSH6 MUT" "SB.216763_IC_50" 0.753818638443819 0.933869109446012 -0.173675570866142 0.682282611638948 0.963201691897013 0.218873665649614 0.925470606463055 0.994026707431102 -0.0497450685314939 "IDH1 MUT" "CCT007093_IC_50" 0.659861535887886 0.902400992643984 -0.315558482142857 0.682504211539778 0.963201691897013 -0.292207618518026 0.661056918489775 0.958689538788368 -0.320384703976664 "HRAS MUT" "Epothilone.B_IC_50" 0.503617272488627 0.846767322410355 0.701076786713277 0.682508807517194 0.963201691897013 0.245075659482945 0.238547123315763 0.875707386589409 1.20564369853194 "CCND2 MUT" "Midostaurin_IC_50" 0.665512254061238 0.904286157943368 0.467548170984452 0.682598216346498 0.963201691897013 0.338519616638679 0.700243210910811 0.961100601384891 -0.462538291670866 "CDKN2A MUT" "Gefitinib_IC_50" 0.365555168285943 0.787984332414431 -0.12816898714257 0.682733338472438 0.963201691897013 -0.0542980672475201 0.35369855980577 0.911252930312559 -0.134595137667775 "CDH1 MUT" "JNK.Inhibitor.VIII_IC_50" 0.45072903655937 0.828077050034054 0.306909735067436 0.682940653925009 0.963201691897013 0.160936000856887 0.821235697181985 0.97739893500462 -0.0995937537596264 "EWS_FLI1 MUT" "GSK269962A_IC_50" 0.876561055592517 0.971594429690931 -0.110332692307693 0.682991208716577 0.963201691897013 0.294672732104327 0.627947384395577 0.952146453272921 -0.393168551988783 "MLH1 MUT" "KU.55933_IC_50" 0.296238465284787 0.747413014259714 -0.399426962395039 0.683264274119097 0.963201691897013 -0.1409062199838 0.466587774583666 0.929276781658587 -0.278165705279729 "FLCN MUT" "CCT007093_IC_50" 0.657062056430152 0.901751651084414 -0.260207382550335 0.6832734834 0.963201691897013 -0.239886514960102 0.893848151434982 0.988301482344111 0.0967037685300587 "STK11 MUT" "PD.0325901_IC_50" 0.741271421227941 0.929570057037101 -0.161689350421744 0.683450288980244 0.963201691897013 -0.188482096657686 0.350807049317929 0.910340341961272 0.42972008022572 "EGFR MUT" "PD.0332991_IC_50" 0.785032651269975 0.946055035513406 0.122760314775161 0.683529855593252 0.963201691897013 -0.146994676302298 0.565220416190424 0.949294892873838 -0.255260629356742 "MYCL1 MUT" "Parthenolide_IC_50" 0.327934848535705 0.769735904120651 0.596077720156552 0.683987886306815 0.963201691897013 0.231890791323413 0.632724793356889 0.952523560833852 0.335385305571242 "PIK3R1 MUT" "PD.173074_IC_50" 0.674362555883911 0.908418658675584 0.215667989130432 0.684028962462407 0.963201691897013 0.178547417044553 0.565464942561021 0.949294892873838 0.27027107769686 "CDH1 MUT" "PD.0332991_IC_50" 0.154384988627134 0.630097924631238 0.999688053757819 0.684149602472091 0.963201691897013 0.231306685062159 0.930772152541956 0.99422596912377 0.0614141854030015 "FGFR3 MUT" "JNK.9L_IC_50" 0.774908023562336 0.941591338606299 -0.227344813471498 0.684176695652925 0.963201691897013 0.25271663065803 0.714263496687445 0.962630898212352 -0.287847457482512 "PDGFRA MUT" "JNK.9L_IC_50" 0.470050121362001 0.832012966658205 -0.445552705372611 0.684217052454114 0.963201691897013 0.196346541352424 0.431901611332109 0.922569292988365 -0.488291191865637 "MS-HL MUT" "KU.55933_IC_50" 0.199298295380913 0.674012093366938 -0.219693197453162 0.684265863678167 0.963201691897013 -0.062195970922022 0.659334846431176 0.958313128388245 -0.081694318231573 "MYCL1 MUT" "CCT018159_IC_50" 0.891459728409878 0.975972789421281 0.0868195402298834 0.684293940868839 0.963201691897013 0.240411946432246 0.94842725227188 0.995668765770473 0.0469877482138817 "MLH1 MUT" "Doxorubicin_IC_50" 0.516207393228768 0.852353345422823 -0.36924670147493 0.684549833352571 0.963201691897013 -0.145258426033377 0.920979759930286 0.993931766508607 -0.0540791320032629 "FLCN MUT" "Pazopanib_IC_50" 0.444430941660919 0.825606373270691 0.647054673076922 0.684592514165555 0.963201691897013 -0.292138768687917 0.139351673162964 0.831473272394224 1.46711017493582 "MLLT3 MUT" "CEP.701_IC_50" 0.995868104854478 0.998977896287767 0.00223429277605868 0.684600812896603 0.963201691897013 0.128358827346365 0.922259489760132 0.993931766508607 0.0400190216607935 "FBXW7 MUT" "AZD6482_IC_50" 0.61493999981721 0.885815598771911 0.214965237499997 0.684664437925008 0.963201691897013 0.146915122239128 0.750810905359044 0.968780465757047 -0.137812781562615 "MYCL1 MUT" "Nilotinib_IC_50" 0.962055021678152 0.994012653885573 -0.0277699558541261 0.685004030637605 0.963201691897013 -0.191264916961852 0.446325444943154 0.925809648901546 -0.43793912072522 "TET2 MUT" "JNK.9L_IC_50" 0.592494106996385 0.87786789526775 -0.425477449050071 0.685055268041037 0.963201691897013 -0.254201157748851 0.605415471294208 0.949657634568742 -0.499237849165594 "KDM6A MUT" "BMS.536924_IC_50" 0.0831950222459092 0.498552626562699 -1.0978408136121 0.685159694352592 0.963201691897013 -0.18999420929653 0.191634868138158 0.851001889249827 -0.85510579207538 "MS-HL MUT" "BMS.509744_IC_50" 0.542762981813819 0.862633715268747 0.179151235408561 0.685268665154849 0.963201691897013 0.0887346472692113 0.147894429264231 0.831473272394224 0.474309006377674 "CTNNB1 MUT" "Rapamycin_IC_50" 0.664262295030399 0.903589924015879 -0.539901704081631 0.685282716356611 0.963201691897013 -0.431014912013609 0.464335408559772 0.929276781658587 1.02308348071336 "CDKN2A MUT" "BMS.754807_IC_50" 0.0586269227199439 0.43716683516022 -0.365703185351488 0.685353214281544 0.963201691897013 0.0688262604924693 0.56134538759619 0.949294892873838 -0.126278830467534 "CDK6 MUT" "Lapatinib_IC_50" 0.727976742415982 0.926240895328988 0.359526401384085 0.68544851024465 0.963201691897013 0.363930562327381 0.794158750513031 0.975393509832241 0.289755892746826 "EP300 MUT" "Docetaxel_IC_50" 0.147027133752783 0.619919550890177 -1.51609455577047 0.685497417693437 0.963201691897013 0.319386638518812 0.256434493564302 0.875707386589409 -1.13679296233605 "VHL MUT" "CGP.082996_IC_50" 0.831538398717193 0.958611936552287 0.156942783505155 0.685645938091508 0.963201691897013 0.257592050383256 0.604066211865967 0.949657634568742 -0.44241598769603 "ERBB2 MUT" "FTI.277_IC_50" 0.929601922511695 0.986689293492114 0.0239634400832895 0.685679043661104 0.963201691897013 -0.102828441531808 0.569842602516337 0.949294892873838 -0.155147260653798 "ALK MUT" "LFM.A13_IC_50" 0.810838804703445 0.952889749533063 0.187499130434784 0.685781527231562 0.963201691897013 0.299735133261149 0.259555643036003 0.877052916121269 -1.23807092147119 "MS-HL MUT" "AICAR_IC_50" 0.59791725997946 0.879232253518807 -0.122399534128608 0.685822507658832 0.963201691897013 0.0841886282283807 0.714272905160671 0.962630898212352 0.0892142467485787 "GNAS MUT" "GSK.650394_IC_50" 0.463843219880028 0.829490249358073 0.486214834215165 0.685962575065417 0.963201691897013 -0.173287571598258 0.548645528238454 0.947060194029534 0.399410572426161 "MLH1 MUT" "ZM.447439_IC_50" 0.698955710927533 0.914968665673257 -0.188374133562265 0.686265330937509 0.963201691897013 -0.158329710242927 0.691959960999642 0.961100601384891 0.184120668708757 "FAM123B MUT" "OSI.906_IC_50" 0.832566135941433 0.958751873919626 0.193550118881121 0.68633456076482 0.963201691897013 0.349716051676973 0.725454329772616 0.965402608571648 0.327402695106806 "BRCA2 MUT" "MK.2206_IC_50" 0.146657192496885 0.619919550890177 1.29967284057969 0.686356702726444 0.963201691897013 0.290016821819999 0.30897058684108 0.89718581932126 0.892826128653222 "EGFR MUT" "BX.795_IC_50" 0.430443070450109 0.820918238409269 0.280781618446115 0.686420487247034 0.963201691897013 0.111639823701273 0.752026042682333 0.968780465757047 0.104296805330826 "SMARCA4 MUT" "DMOG_IC_50" 0.474084678501889 0.834460661638643 0.408622412587413 0.686432889749829 0.963201691897013 0.206579579004629 0.639208164515018 0.954727162640074 -0.288686353415053 "TP53 MUT" "GW.441756_IC_50" 0.380083354446945 0.797344611908192 0.098344956054186 0.686469718945519 0.963201691897013 -0.0468585925007141 0.427385331285075 0.922428741067589 0.0947548374569324 "SMAD4 MUT" "Methotrexate_IC_50" 0.536160445604307 0.859994020980345 0.271123329817157 0.686541722956927 0.963201691897013 -0.137835328127786 0.76321258301347 0.969901216545994 -0.111161932963829 "BRCA1 MUT" "VX.702_IC_50" 0.420280545256094 0.81490164468446 0.605994042145587 0.686552364147643 0.963201691897013 0.249180945061007 0.426497934501107 0.922428741067589 0.553952458008022 "CDKN2A MUT" "Camptothecin_IC_50" 0.00545697956333055 0.126330772503967 -0.542952426699691 0.68686989371903 0.963201691897013 -0.0519939305538578 0.0775286991396361 0.741811190933953 -0.34684024202987 "BRCA2 MUT" "SL.0101.1_IC_50" 0.971999407634611 0.995220468612913 0.0191960617760619 0.686912686197112 0.963201691897013 -0.193862514291566 0.622710824424381 0.950496524771391 -0.261139329492054 "SETD2 MUT" "AZD.0530_IC_50" 0.265004102500066 0.726697783882931 -1.59736080471378 0.687002577124131 0.963201691897013 -0.504757086366823 0.888403343321642 0.988301482344111 0.191475276783926 "KRAS MUT" "CGP.60474_IC_50" 0.28847249293018 0.743664502093737 -0.428268355470614 0.687085349828791 0.963201691897013 -0.13000809857073 0.166352874550443 0.84067330207935 -0.595608296072516 "NOTCH1 MUT" "S.Trityl.L.cysteine_IC_50" 0.0627194378030462 0.450355270053747 -1.18990946379584 0.687101750642862 0.963201691897013 0.146904615209518 0.0145532092619866 0.489839878474164 -1.82842794446052 "CCND3 MUT" "EHT.1864_IC_50" 0.63951712137694 0.895624997957207 -0.419789285714285 0.687180038268154 0.963201691897013 -0.358196626137251 0.404324123754511 0.917353377955789 -0.722420147745364 "KDM5C MUT" "GSK.650394_IC_50" 0.940545913267369 0.989446598697723 -0.0778806666666707 0.687652481930206 0.963711802433669 0.270912751128582 0.913762838825905 0.990970181109792 -0.112189656693635 "KRAS MUT" "Bexarotene_IC_50" 0.247279436651793 0.714668105985286 -0.221440215373243 0.688137970821215 0.96393688248212 -0.072387401062364 0.136436345485625 0.830541253822459 -0.311280615484556 "JAK2 MUT" "BAY.61.3606_IC_50" 0.362988714210914 0.787293170741334 0.661056864160412 0.688163921641855 0.96393688248212 -0.202809209673083 0.569213624005194 0.949294892873838 0.422514891335702 "FLCN MUT" "AKT.inhibitor.VIII_IC_50" 0.1509459472269 0.625548743500747 1.03207124610051 0.688236146000378 0.96393688248212 0.247377732964687 0.183700332335336 0.851001889249827 1.19957562869111 "KIT MUT" "WO2009093972_IC_50" 0.656990712257983 0.901751651084414 -0.343823435185186 0.688349830372806 0.96393688248212 0.279881069161744 0.844499875731041 0.983349844199673 0.151110100201434 "TET2 MUT" "BX.795_IC_50" 0.0780427685115808 0.486980385654137 -1.62769984313721 0.688555404373481 0.96393688248212 -0.290584064952968 0.269978086090839 0.878819138279722 -1.10840836005431 "MAP2K4 MUT" "RO.3306_IC_50" 0.380875387442183 0.797708787892259 0.376088492695887 0.688589826029437 0.96393688248212 0.164141436231158 0.980367130008819 0.997827228172038 0.01169082608171 "VHL MUT" "Mitomycin.C_IC_50" 0.551612699780597 0.865580796066258 0.469631913005271 0.688643855528861 0.96393688248212 0.248980460482268 0.723218969102582 0.965402608571648 0.294431675176555 "NF2 MUT" "SL.0101.1_IC_50" 0.0944891209250368 0.526778332037195 0.442705879150793 0.68889594075502 0.96393688248212 0.0937858897883054 0.499385093777368 0.934042323734638 0.183854589720032 "VHL MUT" "SL.0101.1_IC_50" 0.393695357352784 0.803073858340542 0.369710266990295 0.688903458546063 0.96393688248212 0.152309111122981 0.899363910524438 0.988704788932507 0.057138769040477 "MYCL1 MUT" "AKT.inhibitor.VIII_IC_50" 0.918488653294932 0.985394748720982 -0.0522745332167822 0.688974522699186 0.96393688248212 -0.175374770121142 0.653756785591489 0.958313128388245 -0.24444397989873 "EP300 MUT" "Nilotinib_IC_50" 0.490413593808434 0.84270247622041 0.654092749683134 0.689062424826768 0.96393688248212 0.308571122301885 0.63030051972529 0.952523560833852 0.408255299478256 "EGFR MUT" "CCT007093_IC_50" 0.528182711175575 0.855147571292734 -0.145968488372092 0.689173311219926 0.96393688248212 -0.0937474963586516 0.76320179676153 0.969901216545994 0.0748260359276777 "MSH6 MUT" "A.443654_IC_50" 0.487600852217876 0.841054887180408 -0.708382143835625 0.689382146599465 0.96393688248212 -0.264851714511956 0.360988713330274 0.91161229252998 -0.945697160447455 "EP300 MUT" "BIRB.0796_IC_50" 0.424823164653178 0.818939554001493 0.561721946564901 0.689488021788329 0.96393688248212 0.270628183221863 0.373323337489943 0.913948248824328 0.615973155025221 "TP53 MUT" "PHA.665752_IC_50" 0.517372170404387 0.852353345422823 -0.106675040509259 0.689500004262968 0.96393688248212 -0.0704839654835402 0.359109738408837 0.91161229252998 -0.169610629879376 "MSH2 MUT" "ATRA_IC_50" 0.11967492797713 0.577626649654834 -1.02025618359482 0.689858852969978 0.96393688248212 -0.206276213343563 0.602592237900032 0.949657634568742 -0.301846761476622 "BRCA1 MUT" "Tipifarnib_IC_50" 0.454861903630976 0.828966839128293 0.839243396160572 0.689973725297716 0.96393688248212 0.298367433143925 0.65395522229427 0.958313128388245 0.499139454197579 "EP300 MUT" "AMG.706_IC_50" 0.272991435239635 0.734000646544246 0.813506934116124 0.690077521919927 0.96393688248212 0.273934127400326 0.215691944342344 0.860576337437605 0.841410121441401 "MSH2 MUT" "Gemcitabine_IC_50" 0.297419152136633 0.748266144511455 -1.60514396842107 0.690202288860026 0.96393688248212 0.414124331634078 0.492085831163124 0.933639405738697 -1.00094856615149 "ALK MUT" "Lapatinib_IC_50" 0.304198143614159 0.753790098615331 1.06120206459054 0.690223463907365 0.96393688248212 0.35964578317751 0.576712392744787 0.949294892873838 0.62157902962896 "ERBB2 MUT" "GNF.2_IC_50" 0.331602523675564 0.772603259108552 -0.705814924914676 0.690377953909245 0.96393688248212 -0.281173315602498 0.548128512772317 0.947060194029534 -0.455691869196373 "PDGFRA MUT" "AICAR_IC_50" 0.741957022785381 0.929570057037101 -0.253750622568093 0.690739356559427 0.96393688248212 -0.274486540353767 0.337798527882008 0.906230588643738 -0.71983314045792 "EGFR MUT" "CCT018159_IC_50" 0.305075227249217 0.754224310561809 -0.331845952380954 0.691057866137689 0.96393688248212 -0.120154144119382 0.318803424668753 0.900918773778407 -0.345073012244071 "FGFR3 MUT" "BI.D1870_IC_50" 0.587409793816959 0.876506729771444 0.618540036190488 0.691072659807076 0.96393688248212 0.390812429452397 0.7371478615505 0.96672489654949 0.361787271910505 "CCND3 MUT" "NU.7441_IC_50" 0.376445043119167 0.795051761241315 0.896215530571986 0.691098677921985 0.96393688248212 0.353589161802247 0.300152314371405 0.894167310052 1.00594155918282 "MYCL1 MUT" "VX.680_IC_50" 0.917490354493014 0.984975746996111 -0.112339026436783 0.691210855503842 0.96393688248212 -0.283828593074508 0.470666996871653 0.929276781658587 -0.841566592865713 "CCND3 MUT" "Vinblastine_IC_50" 0.832758100997658 0.958751873919626 0.267256296015179 0.691224307283176 0.96393688248212 0.363785842663212 0.938047789315419 0.994831655017307 0.0918640560750735 "VHL MUT" "X17.AAG_IC_50" 0.461206419369459 0.828966839128293 -0.576057745664737 0.691409029279089 0.96393688248212 -0.274743971258499 0.572937419678445 0.949294892873838 -0.419510173759749 "NF2 MUT" "GW843682X_IC_50" 0.639281684964396 0.895624997957207 -0.367637505226483 0.691431021414512 0.96393688248212 -0.165428790591422 0.870119397447765 0.98753907730331 -0.145683955462396 "CCND1 MUT" "Vinblastine_IC_50" 0.437605380129044 0.823808548892323 0.284068250793653 0.691541790630153 0.96393688248212 0.105748452945895 0.831893409209573 0.981482581683432 0.0786568706742851 "PTEN MUT" "GDC0941_IC_50" 0.277263938262296 0.735258595314258 -0.257750144473943 0.69157028331484 0.96393688248212 0.077069358408771 0.435964850110445 0.922569292988365 -0.200472786077432 "GNAS MUT" "Salubrinal_IC_50" 0.799206206462074 0.949963513555487 0.220251202749141 0.691985984793667 0.96393688248212 0.282143217840826 0.342773777863845 0.907180409180092 0.83896143677487 "RB1 MUT" "Bortezomib_IC_50" 0.307338389762797 0.755781746844506 0.368440322608697 0.692017687740619 0.96393688248212 0.120157960710446 0.958849558935875 0.99641548698706 0.0208717130052899 "CDKN2C MUT" "Vinorelbine_IC_50" 0.743476752245318 0.929570057037101 0.211358837412588 0.692168176478145 0.96393688248212 -0.187164644973901 0.473201315261268 0.929276781658587 -0.543096666243476 "CDK4 MUT" "Imatinib_IC_50" 0.882410082199627 0.973927829424842 0.145960639730639 0.692206628656791 0.96393688248212 0.387190255227583 0.644511982870601 0.956535915754313 0.483605790987599 "HRAS MUT" "AKT.inhibitor.VIII_IC_50" 0.682335350081639 0.909924137549646 0.294353464471399 0.692464511760775 0.96393688248212 0.245202107503366 0.580793260580123 0.949294892873838 0.38829536606801 "CTNNB1 MUT" "GW843682X_IC_50" 0.70129480262624 0.915500829364901 -0.385758573883164 0.692505495389421 0.96393688248212 0.203655507592826 0.978560239385035 0.997696419805459 0.0311445065718624 "KDM6A MUT" "Rapamycin_IC_50" 0.402790188724555 0.807551344312402 -0.648149783450703 0.692577175961258 0.96393688248212 0.264504573496866 0.405624709542721 0.918000323669952 -0.70995983822926 "SETD2 MUT" "CGP.082996_IC_50" 0.826181866415164 0.957374889826862 0.254853707482994 0.69267584841168 0.96393688248212 0.390761259272458 0.792351499491055 0.975393509832241 0.305184252179489 "EZH2 MUT" "GSK.650394_IC_50" 0.644901333301776 0.896610607131532 0.364697931328327 0.692690248099393 0.96393688248212 0.2012726830654 0.870893599081131 0.98753907730331 0.137879413884314 "MAP2K4 MUT" "PF.562271_IC_50" 0.643472926935827 0.89631417535738 -0.199241104907394 0.692694023712407 0.96393688248212 -0.138808689365468 0.926171806069353 0.994088691803316 -0.0430537378061552 "ALK MUT" "AZD6244_IC_50" 0.705290408078907 0.916279127289171 -0.490661241046826 0.692752769841954 0.96393688248212 -0.467348920835451 0.189962748658352 0.851001889249827 -1.86760659343835 "GNAS MUT" "AZD7762_IC_50" 0.346938882240493 0.782020929432191 0.639391073351645 0.692811807579074 0.96393688248212 -0.209971763716318 0.897079551109383 0.988301482344111 0.0801516186244227 "CDH1 MUT" "BIRB.0796_IC_50" 0.155895904399885 0.63139838220137 0.6141472061657 0.692847035709928 0.96393688248212 0.16605128725532 0.188668196459199 0.851001889249827 0.604967461770672 "EWS_FLI1 MUT" "Erlotinib_IC_50" 0.661501846183248 0.902497277122025 0.231623950786055 0.692966123989682 0.96393688248212 -0.20545390405092 0.834205277434903 0.981482581683432 0.125168177910026 "MYCN MUT" "X681640_IC_50" 0.72301986649656 0.923772037743627 -0.131940782631579 0.69298334821137 0.96393688248212 0.129507549143384 0.50443740866043 0.93503055238173 0.276748521235521 "SMAD4 MUT" "Bryostatin.1_IC_50" 0.653743662788827 0.900904870244158 -0.107743058457086 0.693080751774421 0.96393688248212 0.0921213003130915 0.951945289117311 0.995669074626174 0.0148540645887057 "NF1 MUT" "MK.2206_IC_50" 0.519672966380763 0.852599738673405 0.26896893252362 0.693128413784705 0.96393688248212 0.132775871919265 0.695158200147347 0.961100601384891 0.176005471617471 "VHL MUT" "PF.562271_IC_50" 0.412667514505358 0.812480994891775 -0.447482140243895 0.693157645487887 0.96393688248212 -0.175883701228349 0.469423262236916 0.929276781658587 -0.420499811006226 "FLCN MUT" "SL.0101.1_IC_50" 0.333474146801579 0.773264085106582 0.590508863198462 0.693240048239309 0.96393688248212 0.210145286160349 0.376666927837524 0.914419412871569 0.731247112224776 "EZH2 MUT" "GSK269962A_IC_50" 0.236426048350183 0.709358018715533 1.37624535836178 0.693416599131672 0.963991664589921 0.42747052288 0.179685684213784 0.848722027112292 1.7791435370523 "EWS_FLI1 MUT" "Paclitaxel_IC_50" 0.0604714186150686 0.443886947376523 1.49785095804198 0.693496536996397 0.963991664589921 0.149921409906688 0.161189310512139 0.839927262232576 1.28693609175562 "MDM2 MUT" "ABT.263_IC_50" 0.946663622095767 0.990414144411092 0.0464782591269831 0.693679692088822 0.964038181365725 -0.246522744901461 0.769578161830597 0.969901216545994 -0.175569479802326 "GNAS MUT" "Lenalidomide_IC_50" 0.353547381734026 0.785062892590933 0.350707989443375 0.693893319512886 0.964038181365725 0.130426720373672 0.388010955675646 0.915926348152589 0.31246148298678 "KDM5C MUT" "PD.0325901_IC_50" 0.782267885757811 0.944314407151708 0.359533795634913 0.694021410604249 0.964038181365725 0.480562289989962 0.818426705349099 0.977383317127464 0.259601186104421 "BRCA2 MUT" "ATRA_IC_50" 0.800393843582182 0.950688474635998 0.195983618042231 0.694025077532897 0.964038181365725 -0.241889743630517 0.868248155789258 0.987439092273582 -0.1138232774758 "EGFR MUT" "ABT.888_IC_50" 0.777796936603225 0.941886297362171 0.0649765681368131 0.694123104114562 0.964038181365725 0.0766239924182463 0.449737598554082 0.925809648901546 -0.170722237721426 "FGFR3 MUT" "PHA.665752_IC_50" 0.528066737843833 0.855147571292734 -0.613250570469792 0.694181305014504 0.964038181365725 -0.378580415266452 0.663859418701373 0.959206771190239 -0.433777256636636 "SMAD4 MUT" "Vorinostat_IC_50" 0.370577147451998 0.790333775397838 0.224048932137108 0.694596934167812 0.964464567283355 -0.0771842362187121 0.634728682623971 0.952683020176354 -0.115188970922292 "AKT2 MUT" "FTI.277_IC_50" 0.423304235791317 0.817964516549758 -0.335414414409942 0.694961216700055 0.964735930505679 -0.149393976437511 0.35838217121858 0.91161229252998 -0.369573398145745 "MYCN MUT" "XMD8.85_IC_50" 0.244603584899748 0.713407040228131 0.479186556776557 0.695095395949179 0.964735930505679 0.143537507938843 0.374230233639088 0.913948248824328 -0.428323530341846 "FAM123B MUT" "ABT.263_IC_50" 0.969098418986521 0.994856543446662 -0.048801889758644 0.695142393460152 0.964735930505679 -0.444800159362194 0.760041152595472 0.969901216545994 -0.33617798483247 "AKT2 MUT" "Bleomycin_IC_50" 0.245171146654292 0.714219422852591 -1.4567962857143 0.695226883823482 0.964735930505679 -0.40008566529317 0.188186633987165 0.851001889249827 -1.60825008096176 "AKT2 MUT" "DMOG_IC_50" 0.71913421792008 0.92132587844031 -0.24475234782609 0.695466163689795 0.964863489975584 0.239264260055678 0.457343523078688 0.925841766232465 -0.482902563342292 "EWS_FLI1 MUT" "AZD8055_IC_50" 0.352242378906842 0.784969887597353 -0.35776174123443 0.69553609535229 0.964863489975584 0.127475135345334 0.181669622752777 0.84916206298285 0.576970822658528 "STK11 MUT" "Docetaxel_IC_50" 0.905369987990051 0.980799080670852 0.0478651596526391 0.695769401912918 0.964880401064575 0.11789641912105 0.633139117602031 0.952523560833852 0.197930089630749 "NRAS MUT" "NSC.87877_IC_50" 0.826055998413637 0.957353950399519 0.0394088624338629 0.695840234129949 0.964880401064575 0.0711462183713384 0.890110059224989 0.988301482344111 0.0287485985983488 "MLH1 MUT" "IPA.3_IC_50" 0.141051960145667 0.612732612129672 -0.885510393510332 0.695948255721192 0.964880401064575 0.200230401290705 0.489565909332735 0.933639405738697 -0.389219472656492 "CDKN2C MUT" "CI.1040_IC_50" 0.577820841750875 0.873750949722175 0.35453281660232 0.69607817375854 0.964880401064575 0.223474817026892 0.234630461496187 0.869962136993019 0.714357913010513 "NF2 MUT" "CEP.701_IC_50" 0.329411866455214 0.770681450471221 -0.400858421072364 0.696143251221007 0.964880401064575 -0.118170062146389 0.577591836817698 0.949294892873838 -0.221981607023891 "TET2 MUT" "GDC.0449_IC_50" 0.312351813658824 0.759215564942334 -0.71447413926499 0.696249353206054 0.964880401064575 0.249632670787273 0.576212289888142 0.949294892873838 0.482682209202282 "CDKN2a(p14) MUT" "RO.3306_IC_50" 0.467368773411391 0.831023608668684 -0.0968881480888398 0.696448721730555 0.964880401064575 0.05163332212189 0.960165771142171 0.996507965993903 -0.00744077856336985 "SMAD4 MUT" "Sorafenib_IC_50" 0.598112767704551 0.879232253518807 -0.372959405418717 0.696533768495709 0.964880401064575 -0.272226014462916 0.301683259083889 0.894167310052 -0.798281858586568 "FAM123B MUT" "AZD8055_IC_50" 0.397481519770034 0.805575850542599 0.695303646825384 0.6967786317461 0.964880401064575 -0.24933230444439 0.793220634345095 0.975393509832241 0.209950010519293 "VHL MUT" "AS601245_IC_50" 0.508328794475466 0.848277813132358 -0.424128979789103 0.696817515926896 0.964880401064575 0.20119698407221 0.942599722381206 0.995314665488626 -0.0494809784478649 "MET MUT" "AZD.2281_IC_50" 0.338760622718121 0.776685604917301 0.436441401894695 0.696838482192526 0.964880401064575 -0.134555706645799 0.746494428271533 0.968371047127272 -0.12958469883935 "MYCL1 MUT" "CMK_IC_50" 0.761569915191409 0.93574319967042 0.21372955402299 0.696852031576195 0.964880401064575 -0.253889739247342 0.628391176779805 0.952175822853038 -0.363816905624062 "AKT2 MUT" "LFM.A13_IC_50" 0.859728748204744 0.966322414954601 -0.0743238847117802 0.697015500740878 0.964956299622718 0.153912035438811 0.800168738402565 0.976360691959787 -0.107277555943326 "JAK2 MUT" "BI.D1870_IC_50" 0.358876723954153 0.786601117838604 0.606024006397963 0.697277766832585 0.965068893809755 0.221706329708813 0.409302914050765 0.920915626804887 0.570319311256219 "JAK2 MUT" "ATRA_IC_50" 0.991679967549622 0.998361396647489 -0.00684471924029712 0.697314164123094 0.965068893809755 -0.201191913052985 0.433524817599047 0.922569292988365 -0.490549281055598 "CDKN2A MUT" "Epothilone.B_IC_50" 0.0142265821314505 0.217089821150193 -0.480198557686171 0.697423842521137 0.965070293772237 -0.0457051620997581 0.892253069239684 0.988301482344111 0.0297034151437343 "TET2 MUT" "NVP.TAE684_IC_50" 0.619176187269719 0.887477435756715 -0.707894228956218 0.697886835667841 0.965560521508973 -0.457901210517891 0.483139649250986 0.931761829532683 -1.22138440169747 "STK11 MUT" "Sunitinib_IC_50" 0.708207968796775 0.917841100717424 0.397917103092785 0.698255002403815 0.965618357704331 -0.304607887374916 0.467228330960607 0.929276781658587 -0.769721450220399 "HRAS MUT" "SB.216763_IC_50" 0.960685621158485 0.99365707033384 -0.0294581335952854 0.698465921821029 0.965618357704331 -0.224499048427084 0.896095172460762 0.988301482344111 -0.0752948537229743 "KRAS MUT" "QS11_IC_50" 0.445190028929317 0.825606373270691 -0.178471298940624 0.698505162601352 0.965618357704331 0.0703642512571901 0.232890414381056 0.869962136993019 -0.311209704139192 "GNAS MUT" "BI.2536_IC_50" 0.206419917758614 0.679262390469222 -1.66066659183675 0.698645757346965 0.965618357704331 -0.302510453355641 0.425593274262361 0.922428741067589 -1.09250507663205 "SETD2 MUT" "VX.680_IC_50" 0.355085922605766 0.785252181551816 1.72383901020409 0.698825652792711 0.965618357704331 0.475745963965925 0.302182542311114 0.894167310052 2.00566037537089 "MSH2 MUT" "Sunitinib_IC_50" 0.946955392794326 0.990566648222192 -0.0707434604811005 0.698998881891394 0.965618357704331 0.304276581024383 0.499772699265857 0.934042323734638 0.635988742063882 "NF1 MUT" "S.Trityl.L.cysteine_IC_50" 0.134831251586376 0.601893367640051 0.917874073943664 0.699016982927363 0.965618357704331 0.130773178509586 0.267326494919629 0.877052916121269 0.800561405041068 "KDR MUT" "NVP.BEZ235_IC_50" 0.72500737290587 0.924731250116011 -0.314328832005315 0.699081175862863 0.965618357704331 0.249470771451054 0.799396364475778 0.976360691959787 0.218059003234905 "FLCN MUT" "AZ628_IC_50" 0.823255941323263 0.957106429492329 0.349726180887371 0.699284021274769 0.965618357704331 -0.449876879982574 0.413423018019141 0.921714070263062 -1.95082680714841 "CDH1 MUT" "Epothilone.B_IC_50" 0.436474866567721 0.823808548892323 0.610084311032868 0.699313373035941 0.965618357704331 -0.174952422614777 0.614019866891551 0.950059945073224 0.413106141460378 "MLL_AFF1 MUT" "JNK.9L_IC_50" 0.419229446247031 0.81418600684961 -0.785640729310344 0.699376822764736 0.965618357704331 0.298105465782141 0.708337921242898 0.962630898212352 -0.363275160484536 "SMAD4 MUT" "BI.2536_IC_50" 0.0143392218603524 0.217686545883401 -2.11354445615763 0.699415036335454 0.965618357704331 -0.207137383663608 0.0854260250120385 0.749680540483183 -1.63072022599118 "PDGFRA MUT" "JNJ.26854165_IC_50" 0.779503203627054 0.942683810925913 -0.143429164785554 0.699438258837799 0.965618357704331 0.184897430807533 0.849709378684491 0.984337428855677 0.093243357744109 "TET2 MUT" "AICAR_IC_50" 0.0307338670640065 0.324937468327906 -2.14063294573644 0.699508417594511 0.965618357704331 -0.347647184657194 0.418454820904967 0.922428741067589 -0.950018968826506 "MYCL1 MUT" "Salubrinal_IC_50" 0.577912439512781 0.873750949722175 0.394658362168399 0.699666595651511 0.965618357704331 0.228552690930395 0.599975236255596 0.949657634568742 -0.384838859181607 "MYC MUT" "BAY.61.3606_IC_50" 0.689608932528914 0.912457826249894 0.121017542548559 0.699668295442785 0.965618357704331 0.082081488115054 0.890736867501188 0.988301482344111 -0.0413280313075724 "KDM5C MUT" "BI.D1870_IC_50" 0.861470061850652 0.966384100200122 -0.162599645674305 0.70016808455249 0.966029501220393 0.309633004665937 0.988285879838181 0.998290138630901 -0.0128918508687828 "FGFR2 MUT" "Lapatinib_IC_50" 0.15493529062617 0.630721638230745 1.4677792272203 0.700247486986856 0.966029501220393 0.350895863605493 0.335714740730715 0.905358978582594 1.06481610650023 "CTNNB1 MUT" "ABT.263_IC_50" 0.500360557147444 0.845775049110478 0.428183446879152 0.700561397701794 0.966029501220393 0.219807328958348 0.971658565740238 0.99742775226181 0.0214858550503784 "MAP2K4 MUT" "Vorinostat_IC_50" 0.225914657590591 0.698134056525989 0.447469451807224 0.700824043327192 0.966029501220393 0.108496029003907 0.656186696801352 0.958313128388245 0.166146385488416 "MAP2K4 MUT" "PD.0332991_IC_50" 0.631560624990438 0.893419864692589 0.276239034736841 0.700843359646817 0.966029501220393 0.176862537299876 0.127968686971407 0.820169751013594 -0.90798868169306 "TSC1 MUT" "FH535_IC_50" 0.26803441808402 0.731489745211169 1.24666462086958 0.70102913096881 0.966029501220393 0.370473832352686 0.249105899372854 0.875707386589409 1.23829859605654 "TP53 MUT" "SL.0101.1_IC_50" 0.745481098154033 0.93064627954821 -0.0366073809523812 0.701060675692364 0.966029501220393 -0.0395371313250111 0.180411174591051 0.848722027112292 -0.156460955446841 "MLL_AFF1 MUT" "SL.0101.1_IC_50" 0.239968531583071 0.711340033600749 -1.01247927063338 0.701074292469258 0.966029501220393 0.293267718228572 0.98392299529998 0.998083394775457 0.0169066172323841 "GNAS MUT" "PD.173074_IC_50" 0.789963938325233 0.947551287988439 0.136725563241105 0.7011546168523 0.966029501220393 -0.168119222912007 0.939020997264767 0.994831655017307 -0.0360599334308443 "MSH2 MUT" "S.Trityl.L.cysteine_IC_50" 0.60895772316571 0.884360685431551 0.481388525773198 0.701231110080492 0.966029501220393 -0.198053449160672 0.668434291843365 0.959230524020512 0.416080342224539 "CDH1 MUT" "PAC.1_IC_50" 0.716728144141461 0.921306561002511 0.21040108489828 0.701324051015392 0.966029501220393 -0.188722343972987 0.418656211344028 0.922428741067589 -0.484078179389649 "CCND3 MUT" "LFM.A13_IC_50" 0.489263689161222 0.842246719023224 -0.383635296684127 0.701365798508593 0.966029501220393 -0.200801550340676 0.683747239725592 0.961100601384891 -0.225209134565213 "MAP2K4 MUT" "CCT007093_IC_50" 0.554547994518039 0.867219711096092 0.191192727272728 0.701432952486912 0.966029501220393 0.123831270978798 0.668205833847517 0.959230524020512 0.149039007198758 "EGFR MUT" "Pazopanib_IC_50" 0.93992509608515 0.989446598697723 0.0302182403861248 0.701489050036067 0.966029501220393 -0.131197002363807 0.907664062676327 0.989534075687441 -0.0446680027914901 "MLL_AFF1 MUT" "Roscovitine_IC_50" 0.530987021751231 0.856734402332693 -0.743230344827591 0.701640147334558 0.966087774957862 -0.409337777318932 0.389942136497095 0.915926348152589 -1.02367937946782 "FLT3 MUT" "Cisplatin_IC_50" 0.801153729003807 0.9507092914502 0.241796336501898 0.701905502153756 0.966174224496135 -0.322320290474605 0.607804138738223 0.949657634568742 0.473999323688869 "KDM5C MUT" "AP.24534_IC_50" 0.916034947101921 0.984784694977867 0.1464137716263 0.701946666357791 0.966174224496135 0.47985817150882 0.966103720737088 0.997172246847904 0.0553067482324019 "NF1 MUT" "QS11_IC_50" 0.13070185520071 0.59349449267004 0.630107187961076 0.702124271246744 0.966174224496135 -0.118205338198459 0.469028700902256 0.929276781658587 0.319060995886004 "EP300 MUT" "IPA.3_IC_50" 0.276154994935026 0.735108059249974 1.30055944134726 0.702257318166275 0.966174224496135 0.38517217921775 0.416167618399338 0.922398153848459 0.897724849924946 "PDGFRA MUT" "WO2009093972_IC_50" 0.33877865375202 0.776685604917301 -0.662937587006954 0.702269284104067 0.966174224496135 -0.238182163002958 0.855608317585661 0.984631915507353 -0.126510912087877 "CDK4 MUT" "Vinorelbine_IC_50" 0.839431253050312 0.959424448728358 0.146059939024391 0.702355705980381 0.966174224496135 0.203006101133327 0.669732585519147 0.959230524020512 0.320673922022744 "VHL MUT" "S.Trityl.L.cysteine_IC_50" 0.106067776997156 0.549516047897355 1.51775979725087 0.702464471069873 0.966174224496135 0.201320228253249 0.309450323105819 0.89718581932126 1.13785158648904 "NF2 MUT" "AZD.2281_IC_50" 0.393418952395537 0.803073858340542 0.291427867346941 0.702707107606543 0.966242805138871 0.0989723015678834 0.980448896881661 0.997827228172038 -0.00786946512722145 "GNAS MUT" "NVP.TAE684_IC_50" 0.660581769742903 0.902400992643984 0.542565587837843 0.702773005815665 0.966242805138871 0.385743588231961 0.411551907579903 0.921714070263062 1.04370640018903 "CDH1 MUT" "Tipifarnib_IC_50" 0.236949243909343 0.7095832316724 0.888957980046955 0.70285945837959 0.966242805138871 0.193628278211288 0.33066866162043 0.902810042912437 0.770611729643702 "JAK2 MUT" "Vinblastine_IC_50" 0.771500192217772 0.94006662689823 0.197400841817186 0.703173150093432 0.966242805138871 -0.186994673347575 0.820611887168681 0.977383317127464 -0.157496828812917 "FLT3 MUT" "Z.LLNle.CHO_IC_50" 0.411513465622001 0.812480994891775 -0.864713425483495 0.703251427907017 0.966242805138871 -0.373973303136246 0.716221371415511 0.963437663728078 -0.375389030599508 "KDR MUT" "Camptothecin_IC_50" 0.651753679995761 0.899243470992269 -0.587149658428394 0.703293324854449 0.966242805138871 0.313059691294511 0.615382634783079 0.950126768674963 -0.582874021786599 "FBXW7 MUT" "CCT018159_IC_50" 0.575075306954853 0.872620551543038 0.21535516431925 0.703537794008397 0.966242805138871 0.136126896638247 0.876735960197047 0.987838063957761 0.0630565601610611 "MET MUT" "X681640_IC_50" 0.41882913397003 0.814099702076568 0.401916336776854 0.703555688793953 0.966242805138871 -0.162131405638765 0.928095549101601 0.994186152404781 -0.0420886104364814 "CDK6 MUT" "GW.441756_IC_50" 0.875521331959421 0.971594429690931 -0.0640622032051283 0.703582129069459 0.966242805138871 -0.152068867234464 0.895590799903918 0.988301482344111 -0.0531513991324629 "HRAS MUT" "AUY922_IC_50" 0.804875475631532 0.952510646223648 0.210109410839159 0.703602321904412 0.966242805138871 -0.218505785528919 0.276723221266092 0.884339304808981 0.884085280582737 "SMO MUT" "PF.562271_IC_50" 0.884739945869319 0.974376917071605 -0.15759148448276 0.703936585052105 0.966552382784129 0.335258009754496 0.848200662982994 0.98378870157398 -0.203458767926184 "MSH2 MUT" "SB590885_IC_50" 0.82442265701487 0.957177484110155 -0.153707509494595 0.704133781963404 0.966673692628998 0.220231331523684 0.960757255519852 0.996625877572729 0.0300605506902579 "NOTCH1 MUT" "FH535_IC_50" 0.757272629599771 0.934762260113025 0.124576641265597 0.704434864213861 0.966904473360928 -0.134902222443631 0.117189348836409 0.804295677755908 -0.665776800075772 "CTNNB1 MUT" "Vinorelbine_IC_50" 0.317252420516919 0.761258739353268 -0.529520527336856 0.704519631473771 0.966904473360928 0.147393831482821 0.15995819158756 0.838901067822678 -0.820711840115013 "PIK3CA MUT" "KIN001.135_IC_50" 0.83861234856081 0.959212868273494 0.044885314685315 0.704766268389738 0.967093515075597 0.0816704002797166 0.709367366315063 0.962630898212352 0.0844336489682988 "SMAD4 MUT" "PD.173074_IC_50" 0.101105972518286 0.541317934187221 0.474754066834806 0.70492790861146 0.967165882338696 -0.0958616585329118 0.994616274977652 0.999545005862799 -0.00191707953354173 "CCND3 MUT" "AZD7762_IC_50" 0.86673845265606 0.967996000759365 0.212481020952387 0.705141045662088 0.967308870331325 -0.374472432834054 0.900567370852096 0.988704788932507 0.143286336247676 "STK11 MUT" "Pazopanib_IC_50" 0.98073802111381 0.996332002460735 0.00948549065702226 0.705862070303009 0.967536146825203 -0.126376445385946 0.906509278723335 0.988917021334873 -0.0448444013560125 "KDM6A MUT" "GW.441756_IC_50" 0.856550138278389 0.96514911547635 -0.0558208496588692 0.705989005215144 0.967536146825203 -0.114600270800118 0.971485077763235 0.99742775226181 0.0113251056907135 "MYCL1 MUT" "Paclitaxel_IC_50" 0.849790233791473 0.963526482778845 -0.203430467353953 0.706147583468618 0.967536146825203 -0.178741235182703 0.267775496421603 0.877052916121269 -1.2380091665239 "MYC MUT" "WZ.1.84_IC_50" 0.526697054181444 0.855121165130409 0.225788762254901 0.706211015444313 0.967536146825203 -0.115111120498438 0.714940252578222 0.962630898212352 -0.131385172436508 "CCND3 MUT" "TW.37_IC_50" 0.928486258823836 0.986689293492114 -0.0858275381165926 0.706544017178629 0.967536146825203 -0.325822717997256 0.898477901537662 0.988526046030225 0.116207847143022 "VHL MUT" "Z.LLNle.CHO_IC_50" 0.815047987965641 0.954309977735381 -0.191541604810997 0.706567597510819 0.967536146825203 0.29071409755068 0.168067932938654 0.84067330207935 1.28326026492892 "BRAF MUT" "NVP.BEZ235_IC_50" 0.763254103147587 0.936244886169491 -0.0686430123088878 0.706645491804623 0.967536146825203 0.0675078529056551 0.819867608577872 0.977383317127464 -0.0581851286419881 "HRAS MUT" "DMOG_IC_50" 0.943794803854982 0.990147156460271 0.0566783362218362 0.706706438418279 0.967536146825203 -0.273278971960566 0.554256270511617 0.948071221654821 0.448836130251913 "MYC MUT" "Camptothecin_IC_50" 0.625566967574325 0.890758415749171 0.178278956567371 0.706730211430541 0.967536146825203 0.0875451948849812 0.838133369365282 0.981704379975756 0.0689035597432416 "NRAS MUT" "Etoposide_IC_50" 0.401428932942213 0.806415132522709 -0.32911112910053 0.706860957966201 0.967536146825203 0.0994933854228727 0.832997856724299 0.981482581683432 0.0895999977780646 "KDR MUT" "Nutlin.3a_IC_50" 0.642559157042856 0.896094514063559 0.501409809523809 0.707003660880543 0.967536146825203 0.371997996062883 0.345085163896014 0.908328790918938 0.997451881697496 "MYC MUT" "S.Trityl.L.cysteine_IC_50" 0.718674567791688 0.92132587844031 -0.160054785539216 0.707004423262192 0.967536146825203 0.0932714557477159 0.420203501009712 0.922428741067589 -0.386621328151769 "MLH1 MUT" "CHIR.99021_IC_50" 0.864746733896126 0.967489995749939 0.071288473684211 0.707121800699366 0.967536146825203 -0.150453293408457 0.929348477043151 0.99422596912377 -0.0360498219055379 "FAM123B MUT" "Temsirolimus_IC_50" 0.172981972235007 0.65113493295882 1.55842546000002 0.707310047765806 0.967536146825203 -0.328593789407926 0.814707035822992 0.977383317127464 0.258525610073546 "CDKN2C MUT" "AMG.706_IC_50" 0.701189929097754 0.915500829364901 0.175329367588931 0.70735175008995 0.967536146825203 -0.158492310975526 0.581434494139632 0.949294892873838 0.248723015012021 "FLCN MUT" "NVP.BEZ235_IC_50" 0.853478180426099 0.964541653680809 0.143063309381237 0.707409257279455 0.967536146825203 -0.209674171661593 0.649542235005271 0.957759353990007 -0.470993040578392 "PIK3R1 MUT" "JNK.9L_IC_50" 0.440014427591479 0.824500931653809 0.403191304099387 0.707558469993929 0.967536146825203 -0.153046178400141 0.549085823995991 0.947060194029534 0.309160309795297 "PIK3R1 MUT" "Rapamycin_IC_50" 0.441279575008564 0.825053453821275 1.04713965762712 0.707905789107739 0.967536146825203 -0.436652539435659 0.340467115381034 0.907180409180092 1.30148690280367 "CDKN2A MUT" "AMG.706_IC_50" 0.526231111754148 0.854969048950887 -0.0719709172771667 0.708098293221289 0.967536146825203 0.0409510964250066 0.758773791651802 0.969901216545994 0.0365302198261715 "MDM2 MUT" "Shikonin_IC_50" 0.513996829149908 0.85130999259055 0.425772818181817 0.708149194124526 0.967536146825203 -0.20528038770362 0.466674602423473 0.929276781658587 0.46174681111248 "MYCN MUT" "Midostaurin_IC_50" 0.556146624759799 0.867684663540343 0.256487574927552 0.708196354615222 0.967536146825203 -0.129204242533763 0.0173909834574344 0.513211661128791 -1.08513479572699 "IDH1 MUT" "AZD7762_IC_50" 0.700105100536578 0.915410639012359 -0.487706236190484 0.708252639815399 0.967536146825203 0.3683480146169 0.724199629727854 0.965402608571648 -0.409295915493287 "CDH1 MUT" "MK.2206_IC_50" 0.797489202941697 0.949524851900765 -0.163318693632567 0.708253876258781 0.967536146825203 -0.192996808850222 0.799857668540602 0.976360691959787 -0.169219917863022 "NF2 MUT" "Shikonin_IC_50" 0.34038047853702 0.778500909061878 -0.433322055003816 0.708302041665927 0.967536146825203 -0.144398952494035 0.967630618747373 0.997173634484198 0.019396566420698 "VHL MUT" "GW.441756_IC_50" 0.883143922386621 0.973927829424842 0.0636951218809964 0.708368266666134 0.967536146825203 0.15871014422224 0.863335032396239 0.986779719782626 0.0802066215320655 "FBXW7 MUT" "DMOG_IC_50" 0.844343560145003 0.960498931426639 -0.0763822564935057 0.708476858721095 0.967536146825203 0.131219370446745 0.617961991349723 0.950394619652337 -0.190292589880608 "RB1 MUT" "Elesclomol_IC_50" 0.160676036900088 0.636336191287136 0.424810378944283 0.708491712879616 0.967536146825203 0.0962920609467955 0.0192711165401611 0.520202996939728 0.739174508593671 "EWS_FLI1 MUT" "PAC.1_IC_50" 0.210877159775366 0.68475321973127 -0.564626625148286 0.708596608163063 0.967536146825203 0.150760724147318 0.962042083568395 0.996625877572729 -0.0236701307513583 "TP53 MUT" "PF.02341066_IC_50" 0.56927772492856 0.872389778906173 0.111540526512035 0.708670233491763 0.967536146825203 0.0728318489415121 0.646672491650497 0.957449344088104 0.0966142870541738 "CTNNB1 MUT" "WO2009093972_IC_50" 0.538916914540174 0.861419263046422 0.277219125786162 0.708740544625689 0.967536146825203 0.151963930595018 0.954313610523369 0.99568364368633 -0.0282863830590415 "PIK3R1 MUT" "Obatoclax.Mesylate_IC_50" 0.283967300511093 0.739564104351618 0.878165862478034 0.7088122750786 0.967536146825203 -0.22486865341861 0.593931911069834 0.949294892873838 0.417609984956482 "NOTCH1 MUT" "AZD8055_IC_50" 0.0994015449682149 0.5374999166548 -0.63312782410896 0.70948469228867 0.967536146825203 -0.116437179968837 0.784462086392937 0.974508795043269 -0.11090358790234 "KDR MUT" "GDC0941_IC_50" 0.805462719384783 0.952510646223648 0.259045944444444 0.709923006779074 0.967536146825203 0.315162419678665 0.631171843371231 0.952523560833852 0.507291293309501 "NRAS MUT" "S.Trityl.L.cysteine_IC_50" 0.564106026893312 0.871766547058339 -0.272406251601733 0.710075852532628 0.967536146825203 0.0999039350608158 0.685876793010794 0.961100601384891 -0.218509879387403 "KDM5C MUT" "Cytarabine_IC_50" 0.653789089307803 0.900904870244158 -0.630345425047435 0.710085424384783 0.967536146825203 0.397847353884126 0.438701624881542 0.923376375367667 -0.999381564640287 "PDGFRA MUT" "AZD8055_IC_50" 0.701158907240127 0.915500829364901 -0.244825023904382 0.710107205757729 0.967536146825203 -0.184712328429643 0.66818054711021 0.959230524020512 -0.268943693265225 "KRAS MUT" "GW.441756_IC_50" 0.577655338773102 0.873750949722175 0.0797987113759246 0.710111653119613 0.967536146825203 -0.0552007928084501 0.373321798788705 0.913948248824328 0.146967073693014 "CDK4 MUT" "PHA.665752_IC_50" 0.774168485722423 0.94153218611416 0.278947416107381 0.710249486445008 0.967536146825203 0.360982643360782 0.682346593165482 0.961100601384891 0.40970202774211 "EGFR MUT" "CHIR.99021_IC_50" 0.997234363437722 0.998981694467749 -0.00105812055689492 0.710279689111847 0.967536146825203 -0.108034219118357 0.771619688386909 0.969901216545994 -0.0897848471002447 "NOTCH1 MUT" "Midostaurin_IC_50" 0.964531481364417 0.994434372972651 0.021063871024735 0.710306841623466 0.967536146825203 -0.139462271012727 0.447215857407245 0.925809648901546 -0.360690317650603 "JAK2 MUT" "Imatinib_IC_50" 0.399760318257128 0.805918367644724 0.679199020270275 0.710501648743121 0.967536146825203 0.294384095111386 0.827225502901556 0.980722158759675 0.229577667807247 "EGFR MUT" "Bortezomib_IC_50" 0.403093695455115 0.807551344312402 0.605302325174823 0.710691607163235 0.967536146825203 0.216603913582859 0.0925984710287429 0.76758746139711 1.1677246587869 "CDKN2C MUT" "NVP.TAE684_IC_50" 0.621273385141607 0.888247588669681 -0.500097231292517 0.710722807824313 0.967536146825203 -0.308279388115922 0.874976753336121 0.98777404048288 0.194101415129902 "CDK4 MUT" "Cyclopamine_IC_50" 0.523500341506027 0.854075976778526 0.668946917808224 0.710754526494942 0.967536146825203 0.360348372660608 0.309776759585274 0.89718581932126 1.07240612786641 "EWS_FLI1 MUT" "SB590885_IC_50" 0.467353247548514 0.831023608668684 0.358538943390642 0.710798249359524 0.967536146825203 0.163643630982579 0.139748482151138 0.831473272394224 0.74237712648864 "CDK4 MUT" "LFM.A13_IC_50" 0.880930672939313 0.973189981880763 -0.0589810413005277 0.710898185052813 0.967536146825203 0.137993949096178 0.962540158784237 0.996771409852636 -0.0195423691818398 "SOCS1 MUT" "AMG.706_IC_50" 0.478579637638849 0.836304203722611 -0.643628886718742 0.71123509899263 0.967536146825203 -0.310190877022551 0.478605466749825 0.930304161706959 -0.592314983701285 "EGFR MUT" "BI.2536_IC_50" 0.382106145445881 0.798569876743396 0.63729385714286 0.711248272073179 0.967536146825203 0.159346819909561 0.230233123372167 0.868326388686386 0.915718821105116 "MYC MUT" "AZ628_IC_50" 0.356323974667102 0.786601117838604 0.519856453874537 0.711276352649112 0.967536146825203 0.159394872780308 0.708185182805578 0.962630898212352 -0.192636562010096 "MYC MUT" "Pyrimethamine_IC_50" 0.641720618826446 0.896094514063559 0.226041980882354 0.711348150362795 0.967536146825203 0.15469495904527 0.959645717356425 0.99641548698706 0.0260684252218979 "SMARCA4 MUT" "QS11_IC_50" 0.705998911937248 0.916471600847684 0.225207722936076 0.711356894234926 0.967536146825203 -0.161596665425042 0.699331416907422 0.961100601384891 -0.25290523339764 "RB1 MUT" "OSI.906_IC_50" 0.79935562851032 0.949963513555487 0.0677649073118665 0.711369688778533 0.967536146825203 -0.0954393016196438 0.800228146970678 0.976360691959787 0.076913458705555 "MET MUT" "VX.702_IC_50" 0.29423366712826 0.747036827777118 0.458768592736706 0.71151641924174 0.967536146825203 0.132510435669506 0.80248038106072 0.976365695720597 0.10169091156628 "CDH1 MUT" "AZD6244_IC_50" 0.621759043310813 0.888470163096271 0.393989079331937 0.711600243335628 0.967536146825203 0.272504947360529 0.583914933048931 0.949294892873838 0.420199840868447 "FLT3 MUT" "NVP.TAE684_IC_50" 0.43494436291545 0.823150425912549 -1.11168210774409 0.712030970141499 0.967536146825203 -0.434418672993493 0.605677693714904 0.949657634568742 -0.7422589193278 "CDK4 MUT" "AZD.2281_IC_50" 0.0734271673538751 0.477424621155859 0.90011537924152 0.712044861205426 0.967536146825203 0.140511488964124 0.157980739364824 0.83854630828105 0.65783069108319 "MLL_AFF1 MUT" "AUY922_IC_50" 0.368488418156371 0.789246419666677 -1.20580084695653 0.712144356203024 0.967536146825203 0.336996743083015 0.488419854274643 0.933639405738697 -0.893421165515469 "EGFR MUT" "NVP.TAE684_IC_50" 0.385414565459127 0.798746759187088 0.684939703448277 0.712288219756334 0.967536146825203 0.23650147287578 0.0906721106927195 0.764118629741502 1.35123560224949 "FAM123B MUT" "MK.2206_IC_50" 0.687357443984559 0.911748124009352 0.509088622680402 0.712333135685445 0.967536146825203 0.371246232962914 0.770170355593899 0.969901216545994 0.359734928836365 "NF1 MUT" "JW.7.52.1_IC_50" 0.146938881146529 0.619919550890177 1.14779898245614 0.712422308098586 0.967536146825203 0.178189689062275 0.434825498670563 0.922569292988365 0.725242618479252 "PIK3R1 MUT" "MG.132_IC_50" 0.375415522517254 0.795051761241315 0.944585788395903 0.712518163963097 0.967536146825203 0.345883553821565 0.469310859685101 0.929276781658587 0.710536480023759 "FGFR3 MUT" "AS601245_IC_50" 0.628611828522216 0.891947858940054 -0.504299684088265 0.712743427103432 0.967536146825203 0.307074147201987 0.594334940756095 0.949294892873838 -0.547311660999167 "ALK MUT" "WH.4.023_IC_50" 0.639876208989807 0.895624997957207 0.83626837671233 0.712819741546245 0.967536146825203 -0.57845914719471 0.792215887071608 0.975393509832241 0.514083451693897 "NOTCH1 MUT" "Vinorelbine_IC_50" 0.0280547443066392 0.309508303338214 -1.12517155918726 0.71287721543995 0.967536146825203 -0.144366899606715 0.0784185886999333 0.741811190933953 -0.977072975251261 "KIT MUT" "GDC.0449_IC_50" 0.761047484329391 0.93574319967042 -0.186511879844961 0.712900030878335 0.967536146825203 -0.201477635203581 0.797364660409696 0.976360691959787 -0.157296953077 "MAP2K4 MUT" "QS11_IC_50" 0.963390499179249 0.994159243759316 -0.0252520855155468 0.712908921812521 0.967536146825203 0.148803521200167 0.819929648078743 0.977383317127464 0.134385585071209 "CDK6 MUT" "WH.4.023_IC_50" 0.551550352802822 0.865580796066258 1.22668338794084 0.713257629857091 0.967536146825203 0.662986862411248 0.373597686170716 0.913948248824328 2.09322606447795 "FGFR3 MUT" "BMS.708163_IC_50" 0.899706409100973 0.979202526865899 -0.108412002232143 0.713351871287919 0.967536146825203 -0.318627576197852 0.804375192105196 0.976843440597053 -0.214924888169382 "CDK6 MUT" "Axitinib_IC_50" 0.223522295439126 0.696139064632428 0.72726518547008 0.713404678513841 0.967536146825203 0.185112807161719 0.424984872299246 0.922428741067589 0.418287017384299 "MET MUT" "AICAR_IC_50" 0.343457899658629 0.779915522083427 0.474332889546348 0.71361431249369 0.967536146825203 0.164780911582848 0.66586079770159 0.959206771190239 0.207466192868561 "FGFR3 MUT" "Midostaurin_IC_50" 0.677633282846298 0.908720747099578 -0.449575939550941 0.713904349106106 0.967536146825203 0.305465443432168 0.870178652856733 0.98753907730331 -0.160219902755805 "SMAD4 MUT" "CEP.701_IC_50" 0.305262507182177 0.754224310561809 0.373813163863066 0.713919727213839 0.967536146825203 0.100709313829493 0.437890710862028 0.922569292988365 -0.272513761037058 "NF2 MUT" "JNJ.26854165_IC_50" 0.534044911322493 0.858279561609675 -0.15830713505074 0.714142682184759 0.967536146825203 0.0878960498331414 0.328478872808123 0.902810042912437 0.250302374746669 "CCND1 MUT" "Etoposide_IC_50" 0.190284687464156 0.664991779417723 0.631729698498502 0.714218700005539 0.967536146825203 0.115832521114767 0.663183361868012 0.959206771190239 0.213518171582365 "HRAS MUT" "Lenalidomide_IC_50" 0.783709225858929 0.944974629816073 0.11963199490121 0.714266099820341 0.967536146825203 -0.140516371336204 0.963861931127078 0.997051031866061 -0.0189276906282177 "STK11 MUT" "Z.LLNle.CHO_IC_50" 0.842507817552456 0.960245047977092 -0.16269431958763 0.714378045451846 0.967536146825203 -0.276313729559338 0.728221771154291 0.965402608571648 0.315695080399269 "BRCA2 MUT" "Z.LLNle.CHO_IC_50" 0.640614042073054 0.895951701992251 0.601241336734696 0.714404940369923 0.967536146825203 -0.436265163332071 0.668771834302609 0.959230524020512 0.543865515391555 "IDH1 MUT" "Camptothecin_IC_50" 0.189908549061078 0.664991779417723 -2.08511980455407 0.714435311579095 0.967536146825203 -0.366232200819538 0.24927202908923 0.875707386589409 -1.62786717940879 "SOCS1 MUT" "GW.441756_IC_50" 0.697823583940311 0.914917098377198 0.334559242884248 0.714697704167254 0.967536146825203 0.308392686252725 0.5583180817824 0.94928677421639 0.49947769078482 "KRAS MUT" "AZD8055_IC_50" 0.00161989758045271 0.0592029235061749 0.534488991929983 0.714929310438504 0.967536146825203 -0.0516472775187363 0.0235715074374374 0.56731316409724 0.437361329291292 "PIK3CA MUT" "Bosutinib_IC_50" 0.341522896407182 0.778707276763076 0.251764329831934 0.714964246687762 0.967536146825203 -0.0810345545771483 0.638148482174157 0.953445720127982 0.126858183317057 "FAM123B MUT" "SB.216763_IC_50" 0.487134587781024 0.840863415759626 0.50747663405088 0.715142531082191 0.967536146825203 0.257526642252152 0.570540766389769 0.949294892873838 0.406286687251431 "FGFR2 MUT" "BMS.754807_IC_50" 0.0108680459363742 0.185257420270517 2.93362449912743 0.715236053254879 0.967536146825203 0.357229896862114 0.0801974332489338 0.741811190933953 2.28156542474431 "TET2 MUT" "AZ628_IC_50" 0.389600945745725 0.801307549598838 1.34629318885095 0.715259844754037 0.967536146825203 -0.429630251067268 0.535206695288825 0.943443271455699 1.02180061715926 "CDH1 MUT" "AZD.0530_IC_50" 0.75818136398503 0.934762260113025 -0.28073060884354 0.715307508793083 0.967536146825203 -0.293731353417841 0.793165452497908 0.975393509832241 -0.230809723156978 "FBXW7 MUT" "NU.7441_IC_50" 0.590153376652829 0.876506729771444 0.175777846625767 0.715333364967145 0.967536146825203 0.104886109794609 0.585597609624267 0.949294892873838 0.181244495741756 "APC MUT" "BI.D1870_IC_50" 0.00150024839234374 0.0569603689624804 0.941321247983879 0.715465996617552 0.967536146825203 0.0983980930589219 0.417475281566834 0.922428741067589 0.281417202688301 "MSH6 MUT" "BMS.509744_IC_50" 0.850600648257205 0.963543923108704 0.164242645051193 0.715553947439617 0.967536146825203 0.235528566417466 0.68845162178393 0.961100601384891 0.341285028932389 "MDM2 MUT" "RDEA119_IC_50" 0.550855479986118 0.865580796066258 0.469182827309236 0.715622484719061 0.967536146825203 0.259055518255963 0.779207525069442 0.972337708041191 0.187591733466169 "MDM2 MUT" "JNJ.26854165_IC_50" 0.614890384648386 0.885815598771911 0.183272511415524 0.715676841164958 0.967536146825203 -0.123624035164712 0.701357469171014 0.961100601384891 0.131691130627188 "EWS_FLI1 MUT" "AICAR_IC_50" 0.306153236432182 0.754830733680498 -0.47526776520509 0.71576035578828 0.967536146825203 -0.163044358878264 0.561495542435396 0.949294892873838 0.300242056802653 "ERBB2 MUT" "Tipifarnib_IC_50" 0.421953674982441 0.816598515475934 0.442467001260503 0.715799746032047 0.967536146825203 0.137273377419436 0.882226121442109 0.988301482344111 0.0852094564814673 "HRAS MUT" "Nilotinib_IC_50" 0.351525168334137 0.784966682190403 0.626472217335879 0.715912112012667 0.967536146825203 0.19911015894746 0.271500882514549 0.88032104330475 0.664753763054953 "BCR_ABL MUT" "LFM.A13_IC_50" 0.500079855082039 0.845622466295429 0.374142931937179 0.716063126624011 0.967536146825203 -0.196121870281948 0.913866206878639 0.990970181109792 0.0609354018189008 "CCND1 MUT" "CEP.701_IC_50" 0.414271310836588 0.813632830027793 0.308795635873017 0.716079776373803 0.967536146825203 -0.101730487282126 0.950312903915769 0.995668765770473 -0.0230638607004791 "BRCA2 MUT" "EHT.1864_IC_50" 0.502077716563482 0.846422209719112 -0.381714831460678 0.716093675298536 0.967536146825203 -0.207799910748726 0.381882030499933 0.915134825237766 -0.488570700658169 "MYCN MUT" "Docetaxel_IC_50" 0.876852759145683 0.971594429690931 0.0671890287737922 0.716335309137931 0.967536146825203 -0.122084483719758 0.448059565230768 0.925809648901546 -0.372724847665752 "FLCN MUT" "Embelin_IC_50" 0.297703359870456 0.748701828501963 0.669335122377619 0.716349903359004 0.967536146825203 -0.186415074535834 0.950748237685398 0.995668765770473 -0.0505008719619151 "MDM2 MUT" "XMD8.85_IC_50" 0.743664467272818 0.929570057037101 0.268529584775086 0.716448381231627 0.967536146825203 0.255983162507767 0.765077478283014 0.969901216545994 0.241449215469785 "EGFR MUT" "Nutlin.3a_IC_50" 0.515480008439137 0.852351136650153 0.264377865114561 0.716449994014559 0.967536146825203 0.135545438823186 0.968168944335105 0.997173634484198 -0.0164663830620837 "FLT3 MUT" "A.443654_IC_50" 0.143283991363488 0.61606176606809 -1.71942518543798 0.716489749902834 0.967536146825203 -0.281175503095315 0.176670013559754 0.848618686837376 -1.6319556881693 "JAK2 MUT" "A.770041_IC_50" 0.459430788087016 0.828966839128293 1.0972844319728 0.716654712384551 0.967536146825203 0.436530387339198 0.0963333991471178 0.77097828178369 2.88597917441452 "KDR MUT" "GSK.650394_IC_50" 0.241149702415519 0.711340033600749 -1.41120136817652 0.716659418797279 0.967536146825203 -0.282347667658847 0.25590303489452 0.875707386589409 -1.3759126619985 "BRCA1 MUT" "AZD6482_IC_50" 0.836878891028928 0.959212493377535 -0.18183273310225 0.716732938397543 0.967536146825203 -0.270801603930962 0.771369974829488 0.969901216545994 -0.251323806485937 "MSH6 MUT" "Nilotinib_IC_50" 0.40164021377747 0.806415132522709 -0.522680659277502 0.71677601685498 0.967536146825203 0.182745326430917 0.568706110939596 0.949294892873838 -0.317831078026738 "FBXW7 MUT" "XMD8.85_IC_50" 0.123619839959798 0.583699714338599 -0.900165105633807 0.716854841359063 0.967536146825203 -0.185799529718092 0.422284224248529 0.922428741067589 -0.478243397777111 "APC MUT" "Gemcitabine_IC_50" 0.354274032302093 0.785252181551816 0.692901411201692 0.71700643776354 0.96759370517824 -0.190093639849998 0.699752674001456 0.961100601384891 0.329013708201701 "KDM6A MUT" "Pyrimethamine_IC_50" 0.840862242506829 0.959488317577174 -0.132401649512458 0.717558068237304 0.968107323283493 0.201846668486075 0.850523341682442 0.984453468864253 -0.136935517843956 "MLL_AFF1 MUT" "AICAR_IC_50" 0.0884805911729346 0.51191930306634 -2.06689090909093 0.717605056770097 0.968107323283493 -0.400594400946194 0.520663308325481 0.939635632721979 -0.759671864335285 "CDK4 MUT" "Lapatinib_IC_50" 0.91469064459457 0.984411974629711 -0.135394724137932 0.717940765249145 0.968181241456177 0.396145808487405 0.81597473505894 0.977383317127464 0.259654358440786 "IDH1 MUT" "AICAR_IC_50" 0.635367307543249 0.894673421215244 -0.576096034816247 0.717978686056839 0.968181241456177 -0.390209604000379 0.443923754977378 0.925809648901546 -0.898786733814775 "GNAS MUT" "Nilotinib_IC_50" 0.217612888358924 0.689975030887399 0.719137937619956 0.717986899699401 0.968181241456177 0.170518347449068 0.37413478776507 0.913948248824328 0.465818194052609 "CCND1 MUT" "AZD8055_IC_50" 0.483511025822973 0.839194763643102 0.203976854356848 0.718458584335003 0.968318195837323 0.082184269124297 0.652003240565494 0.958313128388245 0.137294278161772 "SOCS1 MUT" "SB590885_IC_50" 0.144314613153863 0.617666544298534 -1.88065367408902 0.718527740873944 0.968318195837323 -0.389652951014574 0.070499428334695 0.728029561674914 -2.03304574640427 "AKT2 MUT" "Doxorubicin_IC_50" 0.197843280027058 0.674012093366938 -0.954229067919806 0.719064891159924 0.968318195837323 -0.165962372116443 0.181604136254999 0.84916206298285 -0.953565476718898 "KDM6A MUT" "CI.1040_IC_50" 0.0912075407144848 0.516507787943737 -0.765806950490192 0.719067388005005 0.968318195837323 -0.147517272391164 0.124538718602025 0.817150972850516 -0.635311377163034 "KDR MUT" "AZD8055_IC_50" 0.843142238430567 0.960498931426639 0.162658567460316 0.719069660805609 0.968318195837323 0.230258376310489 0.82878362296906 0.981081757090089 0.173952068311426 "PIK3R1 MUT" "Gemcitabine_IC_50" 0.0604777847455909 0.443886947376523 2.70464357293498 0.71908261465336 0.968318195837323 0.346796055153259 0.120587725358443 0.80757178183218 2.08660449675051 "PIK3R1 MUT" "ABT.888_IC_50" 0.456482781960665 0.828966839128293 0.280411707129093 0.719272426159262 0.968318195837323 0.114185320739004 0.418783768747727 0.922428741067589 0.283802218104321 "KIT MUT" "GDC0941_IC_50" 0.54334810871519 0.862633715268747 -0.554090734020614 0.719365165687092 0.968318195837323 -0.264454565339506 0.722776864787432 0.965402608571648 -0.324132200399065 "MLLT3 MUT" "PHA.665752_IC_50" 0.956841728580263 0.99327782426188 0.0238528620689654 0.719414650292288 0.968318195837323 0.156132319980078 0.60849686981667 0.94989603148139 0.243703209975724 "MDM2 MUT" "CMK_IC_50" 0.430258528175368 0.820918238409269 -0.607304659793817 0.719480195890038 0.968318195837323 -0.251547996525525 0.773979906035744 0.971458506585624 -0.22673137249897 "CDKN2a(p14) MUT" "CGP.60474_IC_50" 0.0130857643338032 0.207480784061478 -0.570089665000001 0.719869760889793 0.968318195837323 -0.0664269720297564 0.43131532822949 0.922569292988365 -0.20127661032348 "KDR MUT" "Bryostatin.1_IC_50" 0.932658589821535 0.98681842896288 0.0616637009291515 0.719883927287958 0.968318195837323 0.246606666612096 0.452979813072751 0.925809648901546 0.528545192631362 "MSH2 MUT" "KU.55933_IC_50" 0.418809725879946 0.814099702076568 -0.45592448412699 0.720004111793908 0.968318195837323 -0.180150818551209 0.295269181830703 0.894167310052 -0.581824008183357 "IDH1 MUT" "Shikonin_IC_50" 0.935387810490975 0.988214667968534 -0.117465527586204 0.720091758467009 0.968318195837323 0.4345565089234 0.681608982875661 0.961100601384891 0.583480427129379 "MSH6 MUT" "AZD8055_IC_50" 0.20155723976426 0.674012093366938 -0.743973327345312 0.720185653236837 0.968318195837323 -0.162647582064075 0.248707123491958 0.875707386589409 -0.645910914829653 "MAP2K4 MUT" "KU.55933_IC_50" 0.731463698787976 0.928176068595523 0.125830684104627 0.720194308344827 0.968318195837323 -0.11677819377364 0.873379200321666 0.98777404048288 -0.0637588741043312 "MAP2K4 MUT" "Cisplatin_IC_50" 0.248568970675676 0.715413140877926 0.558340663442945 0.720315517573477 0.968318195837323 0.150290228830052 0.78867826354764 0.975340917051672 -0.137610153072762 "FAM123B MUT" "PD.0332991_IC_50" 0.49864595409177 0.845109283443017 0.944744678350495 0.720359848071023 0.968318195837323 0.398021769328282 0.951739567422756 0.995669074626174 0.078932930158618 "NF2 MUT" "TW.37_IC_50" 0.240058708995942 0.711340033600749 -0.354076975800153 0.720541290246611 0.968318195837323 -0.0987973996254734 0.579137616175437 0.949294892873838 -0.170450182908353 "MYCL1 MUT" "AMG.706_IC_50" 0.928487159945779 0.986689293492114 -0.0437995576218647 0.720661630805638 0.968318195837323 -0.160345908052371 0.954293506452197 0.99568364368633 0.0283678549483661 "FAM123B MUT" "BI.D1870_IC_50" 0.0900017972653407 0.514353900587832 1.36754750286806 0.720962713514597 0.968318195837323 0.249149362238576 0.496186312653682 0.933676180352967 0.52917337643181 "MYC MUT" "Etoposide_IC_50" 0.370094553878349 0.790098493508081 0.344096610172358 0.720975493391481 0.968318195837323 0.0900602247833534 0.744608868367364 0.96773833538847 0.125221732556722 "MSH2 MUT" "CGP.082996_IC_50" 0.525748078818201 0.854969048950887 -0.467973230240552 0.721021166973041 0.968318195837323 -0.22260179061361 0.769090860230514 0.969901216545994 -0.217191179204605 "ALK MUT" "PHA.665752_IC_50" 0.684555980348797 0.910792758273807 0.280198750000001 0.721036346751651 0.968318195837323 0.247530273974043 0.850243667088946 0.984453468864253 -0.155958483557861 "FBXW7 MUT" "S.Trityl.L.cysteine_IC_50" 0.0232864611784517 0.277593371444066 -1.59565650909794 0.721044240857182 0.968318195837323 -0.139843502732834 0.0200132890243549 0.528982201860999 -1.70832974699206 "NRAS MUT" "BMS.509744_IC_50" 0.467398144949902 0.831023608668684 -0.278795927272727 0.72118150931362 0.968318195837323 -0.105331493358046 0.521107212581838 0.939635632721979 0.270884974271532 "AKT2 MUT" "Vinblastine_IC_50" 0.230100688069458 0.703003777790522 0.879687089228806 0.721289086249452 0.968318195837323 0.189585205072353 0.190112599422223 0.851001889249827 0.90842681073882 "HRAS MUT" "ABT.888_IC_50" 0.507507759487285 0.847796212975596 0.28762970441459 0.721421934589373 0.968318195837323 -0.131046824043559 0.664717392683302 0.959206771190239 0.175950050001189 "MS-HL MUT" "CCT007093_IC_50" 0.614605816018922 0.885815598771911 0.0792687688334062 0.721452118412242 0.968318195837323 0.0564243484442013 0.951017618239961 0.995669074626174 -0.0107393813455653 "MET MUT" "Bexarotene_IC_50" 0.94439771739505 0.990147156460271 -0.0341028896562794 0.72148403004189 0.968318195837323 0.155857410957846 0.945033793432389 0.995668765770473 -0.0322708371901538 "STK11 MUT" "PD.173074_IC_50" 0.136483873158155 0.604186327814048 0.466932760532155 0.721544190791777 0.968318195837323 0.0960429290234323 0.387510916911964 0.915785792511616 0.26806896909133 "CDKN2A MUT" "GNF.2_IC_50" 0.0324872307492346 0.332778657766958 -0.32309665781536 0.721577504791285 0.968318195837323 -0.053984289849397 0.760585072285261 0.969901216545994 -0.054401115904248 "KDM6A MUT" "Mitomycin.C_IC_50" 0.482386794501988 0.83890874556778 -0.345974107571089 0.721879627755837 0.968403980978336 0.137981578099512 0.550790776174223 0.947060194029534 -0.302561992697005 "MET MUT" "Lapatinib_IC_50" 0.742140891641916 0.929570057037101 -0.415815413793105 0.721922779992617 0.968403980978336 -0.385950327813462 0.794158750513031 0.975393509832241 0.289755892746826 "EGFR MUT" "BI.D1870_IC_50" 0.698699537559976 0.914968665673257 -0.135661849144914 0.722209975416448 0.968403980978336 -0.107838470066895 0.307038915660783 0.896682870760742 -0.355868837389454 "EZH2 MUT" "Sorafenib_IC_50" 0.385315697197647 0.798746759187088 0.808082000000001 0.722271237151662 0.968403980978336 0.313801022767266 0.551251659832595 0.947060194029534 0.655446142967629 "SMARCA4 MUT" "Vinorelbine_IC_50" 0.852274258747036 0.964196154467744 0.120273802447552 0.722436391672114 0.968403980978336 -0.16744098217646 0.557090518687014 0.949136321936116 -0.426036882848149 "NRAS MUT" "PLX4720_IC_50" 0.0911624826322227 0.516507787943737 -0.550715379004775 0.722594641195724 0.968403980978336 -0.106463006257749 0.457278819139801 0.925841766232465 0.251023313192281 "FBXW7 MUT" "GSK.650394_IC_50" 0.565216307493477 0.871775968539349 -0.260150768550366 0.722861192173484 0.968403980978336 0.104016180947415 0.95995168411905 0.99641548698706 0.0235276665246889 "EGFR MUT" "Bexarotene_IC_50" 0.995906789229266 0.998977896287767 -0.00175347378747445 0.722927922576929 0.968403980978336 -0.108469287073664 0.92950645403076 0.99422596912377 0.0303745194108499 "STK11 MUT" "Bleomycin_IC_50" 0.325355330678568 0.766643855599989 0.676089251808323 0.722953041916136 0.968403980978336 0.19917063187953 0.478458988177872 0.930304161706959 0.499648774257557 "PIK3CA MUT" "SB590885_IC_50" 0.0230541306824524 0.277373398976097 0.644927264104462 0.723217157475377 0.968403980978336 0.0849703282028451 0.211532168931805 0.855272470862467 0.341016150001295 "NRAS MUT" "AUY922_IC_50" 0.255671999760972 0.720311238267775 -0.344715884468178 0.723307553573383 0.968403980978336 -0.0742717368605296 0.986515718645701 0.998124818853736 -0.00560129028857843 "ERBB2 MUT" "IPA.3_IC_50" 0.317197597194538 0.761258739353268 0.508086666176469 0.723376001321493 0.968403980978336 0.155385651423989 0.520885720527324 0.939635632721979 -0.321466128557911 "SOCS1 MUT" "Cisplatin_IC_50" 0.633790438555206 0.89399270048764 -0.559590563567358 0.72368719533955 0.968403980978336 -0.360161388524814 0.697600738089389 0.961100601384891 -0.436656769595866 "MS-HL MUT" "GW.441756_IC_50" 0.702937176936783 0.915500829364901 0.0622647167041345 0.723815353714647 0.968403980978336 0.0566900683509933 0.336314106491735 0.905430766021494 0.170112276231877 "SMO MUT" "BMS.754807_IC_50" 0.737653563375041 0.929497913781745 -0.546195812173915 0.723851931267844 0.968403980978336 0.478855322435614 0.509162630472259 0.938147991955214 -1.0510573863473 "MDM2 MUT" "Doxorubicin_IC_50" 0.253160502183043 0.717874556377469 0.710439685537917 0.72404987620348 0.968403980978336 -0.136536206998765 0.310415670679918 0.89718581932126 0.598405545225605 "NF1 MUT" "Dasatinib_IC_50" 0.292137673718139 0.746611418788718 1.21275198356808 0.724087586807411 0.968403980978336 0.3383409015029 0.583692269516739 0.949294892873838 0.634282215998324 "KDM6A MUT" "A.770041_IC_50" 0.306232984286773 0.754830733680498 -0.671883316725977 0.724429136944731 0.968403980978336 0.189063157785141 0.430522140718968 0.922428741067589 -0.535570951898661 "CDH1 MUT" "Nilotinib_IC_50" 0.700610585215042 0.915410639012359 0.224418863723605 0.724599800570833 0.968403980978336 -0.168555245360108 0.771803690477984 0.969901216545994 -0.163696813995742 "FGFR2 MUT" "ABT.263_IC_50" 0.593820742025964 0.878468193610776 -0.821913494140616 0.724673491490856 0.968403980978336 -0.493505339964736 0.281902821533641 0.887872038823822 -2.02867514678743 "FLT3 MUT" "AUY922_IC_50" 0.608108474920325 0.884186536635135 -0.487123232111703 0.724754960112302 0.968403980978336 0.226526669617625 0.560339419811349 0.949294892873838 -0.532110198281276 "MSH2 MUT" "MK.2206_IC_50" 0.517646767807569 0.852353345422823 -0.439679055357146 0.724771490346242 0.968403980978336 -0.191180625386056 0.995405450589821 0.999545005862799 -0.00384840556712207 "FGFR2 MUT" "Imatinib_IC_50" 0.567641773805705 0.872389778906173 0.461144515765768 0.72479950283448 0.968403980978336 0.286574861730351 0.857746850964252 0.984898622336936 0.186421068859627 "FBXW7 MUT" "GDC0941_IC_50" 0.540055824591602 0.861547651912703 0.26037078275476 0.724825801755776 0.968403980978336 -0.120994693373003 0.695353003361542 0.961100601384891 0.17596737275245 "EZH2 MUT" "Midostaurin_IC_50" 0.892454031429368 0.975972789421281 0.0960616042236044 0.724955216941765 0.968403980978336 -0.192581313780001 0.203105800971179 0.852959543285214 -0.884811458426309 "CDKN2a(p14) MUT" "BMS.536924_IC_50" 0.000504511308568497 0.0302740873743028 -1.05299370768041 0.725074756328193 0.968403980978336 -0.0854771176769997 0.144825364194628 0.831473272394224 -0.479980545435236 "MDM2 MUT" "Bleomycin_IC_50" 0.296794740077122 0.747966539904914 1.09723667195767 0.725133376928812 0.968403980978336 0.300976749905423 0.301103101452128 0.894167310052 1.04435816984554 "MYCN MUT" "Vinblastine_IC_50" 0.564459351531296 0.871766547058339 -0.240491827450978 0.725234471236948 0.968403980978336 -0.109869692850301 0.874269222141544 0.98777404048288 -0.0727097015619738 "FLCN MUT" "Midostaurin_IC_50" 0.348866974930188 0.784376608697468 0.785896281802421 0.725517700600587 0.968403980978336 -0.226705438715684 0.347056032841149 0.909751579693109 0.921701310884461 "EP300 MUT" "AZD6244_IC_50" 0.678046437022621 0.908720747099578 -0.658944156701018 0.725527873683743 0.968403980978336 -0.510882599131953 0.747454386028044 0.968780465757047 -0.453687690794566 "CCND3 MUT" "PF.562271_IC_50" 0.485559969915062 0.840221318124096 -0.536905001730116 0.725690482917838 0.968403980978336 -0.220784256901825 0.509467798704211 0.938202304953595 -0.499021356689038 "NOTCH1 MUT" "Nutlin.3a_IC_50" 0.23057545550373 0.70328674741747 -0.60575467085714 0.72582878518243 0.968403980978336 -0.168973406673803 0.718141518504243 0.964721180904622 -0.192406901420459 "PIK3R1 MUT" "BMS.754807_IC_50" 0.477150882809477 0.835993679974334 0.582545552284713 0.726004636086834 0.968403980978336 -0.23990412894837 0.455298597722865 0.925809648901546 0.597559232570417 "KDM5C MUT" "AZD6244_IC_50" 0.854602855372744 0.964632429914253 0.237759953168039 0.726008900055545 0.968403980978336 0.41292454206318 0.777833636046258 0.972337708041191 0.324749754456239 "MLH1 MUT" "EHT.1864_IC_50" 0.677377732312445 0.908720747099578 0.216259909909908 0.726088316743612 0.968403980978336 0.181415877788036 0.671868233449682 0.960256725054738 0.212783470603349 "KRAS MUT" "S.Trityl.L.cysteine_IC_50" 0.151728198865493 0.625830613280407 -0.648342525402129 0.726144332441558 0.968403980978336 0.0929360242131421 0.261052362059213 0.877052916121269 -0.567462992442262 "EGFR MUT" "Cytarabine_IC_50" 0.151028070799951 0.625597153346254 0.606787084980236 0.72617474709911 0.968403980978336 0.112811258537998 0.437105892660659 0.922569292988365 0.318712355281175 "CDK6 MUT" "BX.795_IC_50" 0.581591915362137 0.876037618780722 0.313743409836067 0.726265167427067 0.968403980978336 -0.153318442596186 0.584663162910932 0.949294892873838 0.27326036118598 "JAK2 MUT" "PD.173074_IC_50" 0.628846711362128 0.89199610982384 0.285907480314956 0.72631771563775 0.968403980978336 0.176911665132223 0.898051243907583 0.988526046030225 0.0769350414952593 "CTNNB1 MUT" "PHA.665752_IC_50" 0.878727016469881 0.971802715567801 0.0862290136054417 0.726329512331031 0.968403980978336 0.1957041491569 0.858771907113509 0.985224768537332 0.114489503019071 "STK11 MUT" "AZD.0530_IC_50" 0.413790820798021 0.813205638306533 -0.744839629251707 0.72640394427276 0.968403980978336 -0.276244165449156 0.886557137228874 0.988301482344111 -0.13954123530386 "HRAS MUT" "JNJ.26854165_IC_50" 0.686538639332384 0.911730003936733 -0.206735711060946 0.72657087338639 0.968403980978336 -0.168303362626461 0.940664419884537 0.995120990231635 -0.0360532656512434 "JAK2 MUT" "X17.AAG_IC_50" 0.390275696852885 0.801837403580487 0.773973978566875 0.726635695040244 0.968403980978336 0.276886675333139 0.249042204659798 0.875707386589409 1.00549219781549 "KRAS MUT" "AUY922_IC_50" 0.0516676647605626 0.405674569168128 -0.438594007243159 0.726753434443397 0.968403980978336 -0.0560660568579189 0.130430500458833 0.824553892801908 -0.372765726959454 "TSC1 MUT" "AICAR_IC_50" 0.268940184684778 0.732006752858616 -1.34244922630561 0.726761717634095 0.968403980978336 -0.380313172184835 0.488820996275019 0.933639405738697 -0.806830375069129 "CTNNB1 MUT" "Bryostatin.1_IC_50" 0.808452057268741 0.952641225877339 -0.0799536931198109 0.726860433924846 0.968403980978336 0.108433504402938 0.816209491424422 0.977383317127464 0.0822762524276243 "NOTCH1 MUT" "Bosutinib_IC_50" 0.0145480904183766 0.219273935922674 -1.18620524728489 0.7268605563353 0.968403980978336 -0.144989719040161 0.76389820520566 0.969901216545994 0.147021385599412 "AKT2 MUT" "CHIR.99021_IC_50" 0.885156136070914 0.974449243426767 0.0788021142857153 0.726875457403625 0.968403980978336 0.18014500433299 0.770105163129847 0.969901216545994 -0.155737182258303 "NF2 MUT" "AZD6244_IC_50" 0.915413895490379 0.98476490303336 -0.0543359775160605 0.727027499370138 0.968461260222918 0.164806616391453 0.570959734193878 0.949294892873838 -0.277693336659621 "ERBB2 MUT" "BX.795_IC_50" 0.00528398732711768 0.124415842357912 1.12793684166667 0.727182908333493 0.968523006735116 0.112491584774199 0.566651534001515 0.949294892873838 0.218302819963051 "EGFR MUT" "PF.4708671_IC_50" 0.806604108594936 0.952641225877339 -0.0658039485981307 0.727810528052839 0.968715858066684 0.0932674711027 0.855547795359461 0.984631915507353 0.0526221970805319 "MLL_AFF1 MUT" "Bosutinib_IC_50" 0.115350092692616 0.568406140842131 -2.00252142666672 0.728069610391401 0.968715858066684 -0.3702645388275 0.816240037205362 0.977383317127464 -0.277003040435825 "NOTCH1 MUT" "XMD8.85_IC_50" 0.214327731120796 0.688117861819268 -0.69387869257951 0.728226819614634 0.968715858066684 0.175527336163272 0.864662900680396 0.987077901072027 -0.10815440113359 "CDKN2C MUT" "Methotrexate_IC_50" 0.312751249378254 0.759215564942334 0.796694675456399 0.728302612581778 0.968715858066684 0.20774339978562 0.366735254107976 0.913948248824328 0.604720770672405 "STK11 MUT" "WH.4.023_IC_50" 0.6471303502595 0.897186614618066 -0.73306540893471 0.728373146933125 0.968715858066684 -0.484923493567088 0.906005181144102 0.988917021334873 -0.201249045228537 "AKT2 MUT" "NSC.87877_IC_50" 0.449282234790915 0.827644788877436 -0.321998385093172 0.728598579453209 0.968715858066684 -0.144919002894105 0.543776314764843 0.946853280734584 -0.265401549676944 "VHL MUT" "BX.795_IC_50" 0.903585237975268 0.97982179468356 0.0689768114754022 0.728611196841937 0.968715858066684 0.152969949146675 0.399441165409247 0.916480913435499 0.45827250502508 "BRAF MUT" "FTI.277_IC_50" 0.043535816848795 0.374825086237107 -0.314629910988442 0.728726576812694 0.968715858066684 -0.054273164659802 0.857587200772003 0.984898622336936 -0.0318169170752925 "NF1 MUT" "WH.4.023_IC_50" 0.245270828880975 0.714219422852591 1.21463438732395 0.728892948469685 0.968715858066684 0.318347115933742 0.368628677756182 0.913948248824328 1.01344807836872 "IDH1 MUT" "Axitinib_IC_50" 0.955102435141039 0.992680805843952 0.070932451612903 0.728905146561465 0.968715858066684 0.36663878666629 0.529346288665986 0.943054040048671 0.700368944520708 "SETD2 MUT" "Midostaurin_IC_50" 0.724087339842429 0.924072376079985 -0.467180636206906 0.729596709015199 0.968715858066684 -0.353681884015015 0.77333720750386 0.971176188062204 0.346828757204033 "MET MUT" "FTI.277_IC_50" 0.513396808448165 0.85130999259055 -0.219181263174652 0.729613186384552 0.968715858066684 -0.105960346406465 0.847909286342909 0.98378870157398 -0.0609893090233665 "BRCA1 MUT" "FH535_IC_50" 0.965569952003841 0.994434372972651 -0.0344327757417107 0.729881038615718 0.968715858066684 -0.236421574249889 0.926787825464434 0.994186152404781 0.0706925136902702 "MSH6 MUT" "Vorinostat_IC_50" 0.597013700573381 0.879232253518807 -0.300728728712876 0.730451203404476 0.968715858066684 0.149939060148369 0.935960882816304 0.994729228933513 -0.0415871070662005 "PDGFRA MUT" "AZD.2281_IC_50" 0.664721208362951 0.903873756743204 0.291643574257427 0.730630255744429 0.968715858066684 0.174841178793684 0.637040437950259 0.953101495776253 0.283580030241892 "FLCN MUT" "Cisplatin_IC_50" 0.774151488518381 0.94153218611416 0.238805805714286 0.730641661512256 0.968715858066684 0.248046930779343 0.730552384366639 0.96639568318693 -0.387041887030341 "EGFR MUT" "AP.24534_IC_50" 0.25850624664787 0.723084717001489 0.665054903787824 0.730665025700589 0.968715858066684 0.183208908353156 0.472219291057233 0.929276781658587 0.417887320416957 "EZH2 MUT" "Doxorubicin_IC_50" 0.863497772790405 0.967296130190664 -0.127489295989977 0.730670858939815 0.968715858066684 -0.158805461183947 0.624602828348816 0.950496524771391 -0.371893761747992 "BCR_ABL MUT" "KU.55933_IC_50" 0.0617131077250746 0.448143941425676 -1.35560902503295 0.730682328427057 0.968715858066684 -0.283018872402916 0.397452459870545 0.916480913435499 -0.6231015357443 "KDR MUT" "AP.24534_IC_50" 0.432207706377231 0.821407370069804 -1.25806069084628 0.730823704957309 0.968715858066684 -0.495128062852086 0.894610491336873 0.988301482344111 -0.201616066424116 "AKT2 MUT" "Gemcitabine_IC_50" 0.255645756388905 0.720311238267775 -1.75096011127821 0.730999561312111 0.968715858066684 -0.35416590019435 0.127296573776895 0.817440977377154 -2.2251458333479 "FGFR2 MUT" "WO2009093972_IC_50" 0.808777266083243 0.952641225877339 0.264393723502306 0.731000816044665 0.968715858066684 0.34117230382876 0.301305021596462 0.894167310052 1.57212353880675 "MLL_AFF1 MUT" "Parthenolide_IC_50" 0.507511885654741 0.847796212975596 -0.749382727272717 0.73104795211009 0.968715858066684 -0.367487037017921 0.494477555189414 0.933639405738697 -0.797501990480291 "HRAS MUT" "BI.D1870_IC_50" 0.837378667673033 0.959212493377535 0.135620030070378 0.73107261339324 0.968715858066684 0.196614487626904 0.878694110269813 0.987955687349291 -0.0956117372223127 "GNAS MUT" "JW.7.52.1_IC_50" 0.194885799195332 0.670441006096806 -2.02067425170069 0.731128925216024 0.968715858066684 -0.323948582397255 0.386799787421011 0.915662729926209 -1.37868512106714 "CTNNB1 MUT" "A.770041_IC_50" 0.416843189087211 0.814099702076568 -0.855840625429558 0.731307059376892 0.968715858066684 0.293136857302403 0.789055415760416 0.975340917051672 -0.297955808211226 "VHL MUT" "BMS.754807_IC_50" 0.67993931264421 0.909220155851267 -0.33811283369947 0.73162384941613 0.968715858066684 -0.236274416468604 0.798637171008643 0.976360691959787 0.222287852658686 "FLT3 MUT" "BMS.509744_IC_50" 0.182185564710766 0.658636992153339 -1.3389861564626 0.731636743275958 0.968715858066684 -0.257441673232898 0.518370713829329 0.939635632721979 -0.641542332317245 "CDKN2A MUT" "AKT.inhibitor.VIII_IC_50" 0.188345890303651 0.663245512002727 -0.176358164007382 0.731922547221747 0.968715858066684 0.0413477517400312 0.529781971961458 0.94315521189351 -0.0943730485999302 "KRAS MUT" "EHT.1864_IC_50" 0.259117395961453 0.723189643810247 0.177628143093465 0.731948367248425 0.968715858066684 0.0568625631937903 0.503253295695332 0.934042323734638 0.119100942476254 "CDKN2A MUT" "Nilotinib_IC_50" 0.185494504957565 0.660621300857439 -0.189168048218966 0.732223186186872 0.968715858066684 0.0409510856938187 0.710737532591871 0.962630898212352 -0.0542355917221854 "MDM2 MUT" "PD.0332991_IC_50" 0.306010935394489 0.754830733680498 0.678467685030216 0.732224283708565 0.968715858066684 -0.181036669757952 0.404073303382047 0.917324899625757 0.514479875244689 "EGFR MUT" "RO.3306_IC_50" 0.520614343627818 0.852599738673405 0.20571859571323 0.732327989757531 0.968715858066684 0.104692213252991 0.391833183349479 0.915926348152589 0.287227504954038 "SETD2 MUT" "GSK269962A_IC_50" 0.919213557508555 0.985815191913232 -0.16636020338983 0.732488261875452 0.968715858066684 0.530732103269957 0.475174058511782 0.929844139269115 1.17765309420348 "JAK2 MUT" "GNF.2_IC_50" 0.566405860482897 0.872389778906173 0.417031946530145 0.732581795458949 0.968715858066684 0.236330555015757 0.761401071190907 0.969901216545994 0.277267910253564 "KRAS MUT" "PF.4708671_IC_50" 0.191143966917206 0.666489819470635 0.191185020790022 0.732663710601527 0.968715858066684 0.0524667690611995 0.270041187179206 0.878819138279722 0.190161560508742 "TSC1 MUT" "SB.216763_IC_50" 0.612825860856685 0.88496040166963 -0.521690916179338 0.732813395599009 0.968715858066684 -0.340949332461713 0.765707687220507 0.969901216545994 -0.296333463265075 "MSH6 MUT" "FTI.277_IC_50" 0.787293573896125 0.946449577332088 -0.105848395470383 0.732900508297995 0.968715858066684 -0.12172978726438 0.536224398515349 0.943443271455699 -0.228838230011549 "MYCL1 MUT" "Elesclomol_IC_50" 0.425945316575678 0.819381892124907 0.617630849808061 0.732966778888601 0.968715858066684 0.219373095317746 0.758716601908124 0.969901216545994 0.246712830717849 "MLH1 MUT" "Bicalutamide_IC_50" 0.22273165045931 0.695771997090794 0.220510421828911 0.733055453144535 0.968715858066684 0.059453942233545 0.45025201786074 0.925809648901546 0.128860579239585 "MLLT3 MUT" "JNK.9L_IC_50" 0.521674775111516 0.853303159804623 -0.191254058766233 0.733227231636489 0.968715858066684 0.0793533886116663 0.927784425810876 0.994186152404781 -0.0279723969304838 "EZH2 MUT" "PF.02341066_IC_50" 0.554404863781945 0.867148572604343 0.483873449324329 0.733391066291116 0.968715858066684 -0.25815530860228 0.0753165517747897 0.741811190933953 1.63298874973466 "CDKN2C MUT" "Bryostatin.1_IC_50" 0.601210031175927 0.880741900288913 -0.21016766137566 0.733414320248081 0.968715858066684 -0.129618377890699 0.883731594770215 0.988301482344111 0.0670557160580972 "EZH2 MUT" "NSC.87877_IC_50" 0.738649600571044 0.929570057037101 -0.142019403726711 0.733416562774847 0.968715858066684 -0.141939221162806 0.432937453530978 0.922569292988365 -0.364747513712016 "MDM2 MUT" "Docetaxel_IC_50" 0.410700772070626 0.812480994891775 0.474641192156858 0.733425671036901 0.968715858066684 -0.147294007561265 0.35701790909545 0.91161229252998 0.509147467141299 "MYC MUT" "Mitomycin.C_IC_50" 0.578071878787974 0.873750949722175 -0.195356131957147 0.733510823080281 0.968715858066684 -0.0942949728133649 0.131900595013785 0.824721122422311 -0.543413473387975 "KIT MUT" "PHA.665752_IC_50" 0.299248926477633 0.750344870252218 -1.00833446308724 0.733934039265391 0.968715858066684 -0.342047345266295 0.697039586987457 0.961100601384891 -0.390924361931449 "CTNNB1 MUT" "AUY922_IC_50" 0.0999185236878963 0.5374999166548 -0.814094941281148 0.733966984810482 0.968715858066684 -0.112871748588334 0.428057141975489 0.922428741067589 -0.421275889218722 "FLT3 MUT" "MS.275_IC_50" 0.21200007683703 0.686391790882124 -1.58673001027395 0.73401206258081 0.968715858066684 -0.363229065935456 0.386513637907172 0.915662729926209 -1.15104228298253 "HRAS MUT" "X681640_IC_50" 0.99893384900066 0.999548905963057 0.00126205691056844 0.734087712264431 0.968715858066684 -0.274134270075958 0.956364021227274 0.996361528879345 0.0483515820843311 "SMARCB1 MUT" "Tipifarnib_IC_50" 0.420075454663853 0.81490164468446 -1.27822015478262 0.734136199983538 0.968715858066684 -0.357002941206803 0.548717793050718 0.947060194029534 -0.947402321580977 "EWS_FLI1 MUT" "ABT.263_IC_50" 0.234989395632843 0.707962074581044 -0.699652057999998 0.734143884067921 0.968715858066684 0.192709094467055 0.433718334409754 0.922569292988365 0.464904276419674 "CTNNB1 MUT" "Pazopanib_IC_50" 0.79105968269233 0.94790644179192 -0.130598152431792 0.734224447262365 0.968715858066684 0.142140264110789 0.943111485337951 0.995314665488626 0.0360928379508773 "SMO MUT" "OSI.906_IC_50" 0.900814753186299 0.979448558159589 -0.179942810434784 0.734324800888509 0.968715858066684 0.461162169216085 0.727681957475313 0.965402608571648 -0.502777018016497 "CDKN2A MUT" "Bryostatin.1_IC_50" 0.015068350947015 0.223036707934066 -0.257160699128939 0.734704352554442 0.968715858066684 -0.0356005266718388 0.90055923786219 0.988704788932507 -0.0144937152254089 "PIK3R1 MUT" "ATRA_IC_50" 0.394951207451294 0.80356510272049 0.522634469111974 0.734782857662408 0.968715858066684 0.163883478301621 0.573620935922055 0.949294892873838 0.302103075476343 "MS-HL MUT" "Vinorelbine_IC_50" 0.0773312540440428 0.486043076549996 -0.455168543805805 0.734792248620896 0.968715858066684 0.0648900660711862 0.0133377793445212 0.482141194305023 -0.695939431372468 "FLT3 MUT" "BX.795_IC_50" 0.150534624939883 0.625010754600796 1.62560664777326 0.734906398962936 0.968715858066684 0.297821354734082 0.0788960338483996 0.741811190933953 1.74632688367752 "MS-HL MUT" "Z.LLNle.CHO_IC_50" 0.616247851550993 0.885815598771911 -0.156331828095381 0.734989528859939 0.968715858066684 -0.0981205717845942 0.719276457015389 0.964898274809486 0.123561303937535 "MSH2 MUT" "NVP.TAE684_IC_50" 0.767779418897789 0.938432290012561 0.326913132203389 0.735081782164218 0.968715858066684 -0.308627843244157 0.762072719507252 0.969901216545994 0.340585620442674 "PTEN MUT" "Imatinib_IC_50" 0.595195016633529 0.878837476080544 0.117390135933807 0.735282666309756 0.968715858066684 0.0750875233305716 0.23539229987549 0.869962136993019 0.298715912075821 "SMARCA4 MUT" "A.443654_IC_50" 0.671232438112554 0.906916702390321 0.499458500568825 0.735395765432599 0.968715858066684 0.258539594702398 0.56891953100352 0.949294892873838 1.17509329773769 "IDH1 MUT" "BAY.61.3606_IC_50" 0.619122811728022 0.887477435756715 -0.673028601739135 0.735419226218092 0.968715858066684 -0.316997837132791 0.604945222273165 0.949657634568742 -0.661648890847846 "CDK6 MUT" "Tipifarnib_IC_50" 0.878377974007588 0.971802715567801 0.121967728031635 0.735567373383528 0.968715858066684 -0.179085621193662 0.599919431703101 0.949657634568742 0.439901516047178 "NRAS MUT" "RO.3306_IC_50" 0.734300669436627 0.928593402067957 -0.0897679758079746 0.73569401162458 0.968715858066684 0.088313196412908 0.344523968821878 0.908197496915138 -0.286258297940438 "CDH1 MUT" "FTI.277_IC_50" 0.352824072961478 0.785062892590933 0.343817497382201 0.735737473686032 0.968715858066684 0.115472987344963 0.502977797487388 0.934042323734638 0.251976936119165 "ALK MUT" "RO.3306_IC_50" 0.46072599205066 0.828966839128293 -0.62764675799087 0.735742301513666 0.968715858066684 -0.27465785597508 0.640799131625193 0.955103296458244 0.488214754755334 "CCND3 MUT" "Epothilone.B_IC_50" 0.925385033616955 0.98643792569589 -0.109683774869112 0.735798689427069 0.968715858066684 0.225402996072637 0.936658045870627 0.99481859098592 0.0908674605854832 "MDM2 MUT" "PHA.665752_IC_50" 0.70415427570601 0.915500829364901 0.234648576271186 0.73582857781013 0.968715858066684 0.207385307324698 0.665580760901729 0.959206771190239 0.273894991134912 "CCND3 MUT" "Bryostatin.1_IC_50" 0.497763859698508 0.844923707565453 -0.42877770331589 0.735842858687786 0.968715858066684 -0.201463655490666 0.916745150898874 0.992403322408462 -0.0632221966916052 "EZH2 MUT" "Salubrinal_IC_50" 0.18198399556689 0.658636992153339 1.15393634020619 0.735989738857982 0.968715858066684 0.239792917503658 0.0494475676302388 0.679896345274018 1.93067321115281 "EGFR MUT" "Pyrimethamine_IC_50" 0.27411112235426 0.73402283606276 0.817127177700352 0.735997716537636 0.968715858066684 0.211211811467656 0.502488572660735 0.934042323734638 0.508088769751297 "PDGFRA MUT" "SL.0101.1_IC_50" 0.633716544563544 0.89399270048764 0.260563590733588 0.73617768550506 0.968715858066684 -0.160950903967704 0.993397070279601 0.999469155159075 0.00441442412015556 "AKT2 MUT" "Cytarabine_IC_50" 0.547753637783246 0.863742907875179 0.48959917654557 0.736245569255404 0.968715858066684 -0.20820652515306 0.648640515472076 0.957493413330814 0.346346467856996 "STK11 MUT" "Cyclopamine_IC_50" 0.901227500075274 0.979586077148392 -0.0827612456747396 0.736356128187117 0.968715858066684 -0.206793029325194 0.811220061104624 0.977383317127464 0.181896578934296 "PTEN MUT" "NVP.TAE684_IC_50" 0.538115968566744 0.860998762866154 0.237963274801586 0.736373113654581 0.968715858066684 0.108530563287364 0.270534628945536 0.879734431423575 0.460674693786454 "FAM123B MUT" "FH535_IC_50" 0.797885279092688 0.949524851900765 -0.182867211538464 0.736430933901971 0.968715858066684 -0.205876896221824 0.995737732498077 0.999545005862799 -0.00370272762329381 "BRCA1 MUT" "NVP.BEZ235_IC_50" 0.259147288039523 0.723189643810247 0.873577812874248 0.736479701040103 0.968715858066684 0.188622133371373 0.296296216940621 0.894167310052 0.764701170166167 "RB1 MUT" "KU.55933_IC_50" 0.492268178529541 0.842990705166559 -0.129494813664596 0.736653657480873 0.968715858066684 -0.0575266318963216 0.255346677526324 0.875707386589409 -0.2346272372575 "NRAS MUT" "OSI.906_IC_50" 0.511978674742336 0.850043486705307 -0.214150041210502 0.736868822390423 0.968715858066684 0.106785796050874 0.863511223526345 0.986854095500897 -0.0644721293566396 "BRCA2 MUT" "ZM.447439_IC_50" 0.136879911316785 0.604353219297467 1.19206627254902 0.737099991534212 0.968715858066684 0.214927859987815 0.541892292557093 0.945765861891114 0.464090068084215 "GNAS MUT" "Cyclopamine_IC_50" 0.885942010732878 0.974449243426767 -0.106756206896554 0.737205535441943 0.968715858066684 -0.229068875479969 0.955683272802521 0.996100446818628 0.0426456803903093 "MDM2 MUT" "Embelin_IC_50" 0.300621705847553 0.751119785777076 0.47251414462081 0.737457460028365 0.968715858066684 0.122167787863353 0.172105800218331 0.842832361237713 0.614306539975682 "CDKN2C MUT" "RDEA119_IC_50" 0.763920673513277 0.936244886169491 0.250352980961923 0.737738555289455 0.968715858066684 0.253450089838906 0.284918680281425 0.8879937007725 0.81683425738874 "BRCA1 MUT" "Nilotinib_IC_50" 0.640951395772209 0.896000211845268 0.38347462476191 0.73779531434091 0.968715858066684 0.223592401475109 0.898153420959632 0.988526046030225 0.0943133476204331 "PIK3CA MUT" "Etoposide_IC_50" 0.461161502764073 0.828966839128293 -0.25781652588384 0.737804382441414 0.968715858066684 -0.0768862006381904 0.285692585824595 0.8879937007725 -0.388209726231359 "PTEN MUT" "IPA.3_IC_50" 0.891597979646024 0.975972789421281 -0.0330436869918702 0.738033479438113 0.968715858066684 0.069663490808008 0.97290862591378 0.99742775226181 -0.00828623843277808 "BRCA1 MUT" "Temsirolimus_IC_50" 0.152467726375637 0.625830613280407 1.63625647428573 0.738286190903648 0.968715858066684 0.29342125809521 0.140424627167068 0.831473272394224 1.59378887998287 "TET2 MUT" "MS.275_IC_50" 0.256806867583402 0.721056525769268 -1.44198805821916 0.738392865066913 0.968715858066684 -0.356311957957265 0.21483174524841 0.859434499119166 -1.99655013549807 "SMARCA4 MUT" "Nilotinib_IC_50" 0.64294381912126 0.896094514063559 0.242473628131022 0.738446137388626 0.968715858066684 -0.140853245703429 0.997791504214134 0.99968575015939 0.00148552093340741 "FGFR3 MUT" "Axitinib_IC_50" 0.755825791118735 0.934654823707749 -0.391766884250472 0.738537670423474 0.968715858066684 -0.354998037043418 0.320533679266899 0.900918773778407 -1.09543959922647 "SMAD4 MUT" "Salubrinal_IC_50" 0.443013388661178 0.825539266593482 -0.504477331349203 0.738568551053959 0.968715858066684 0.187422077196821 0.190566450086956 0.851001889249827 -0.905276209499595 "MYCL1 MUT" "BAY.61.3606_IC_50" 0.709041767486642 0.918331622728434 -0.227535164021166 0.738627281039852 0.968715858066684 -0.14136454136888 0.62183004023487 0.950496524771391 -0.308450478400145 "MSH6 MUT" "BAY.61.3606_IC_50" 0.547040240717727 0.863384463802049 -0.409791177065028 0.738642125151388 0.968715858066684 0.157442193964568 0.77748629400654 0.972337708041191 -0.179483074476083 "CDKN2a(p14) MUT" "VX.680_IC_50" 0.00163902586830493 0.0594684279920107 -1.01932790583334 0.738988818847323 0.968715858066684 -0.0761925552896527 0.0135978130912322 0.482141194305023 -0.940719019754264 "CTNNB1 MUT" "QS11_IC_50" 0.544144018876062 0.862633715268747 -0.311165868920526 0.739020834199851 0.968715858066684 0.125442010418222 0.949270434089567 0.995668765770473 0.0357917958478154 "STK11 MUT" "Gefitinib_IC_50" 0.65051883869214 0.898942914483331 0.160181934014702 0.739054563271238 0.968715858066684 -0.10620323409497 0.494582933353334 0.933639405738697 0.232479956638833 "NRAS MUT" "CCT018159_IC_50" 0.896456734967211 0.977342531701915 -0.0372194537346713 0.739136840737886 0.968715858066684 -0.0919712450496673 0.962408876841773 0.996771409852636 0.016026264850037 "EGFR MUT" "PD.0325901_IC_50" 0.628267760621658 0.891895646036614 0.237088957450797 0.739289778557928 0.968715858066684 0.153848773057857 0.375593569649351 0.914419412871569 0.398078247096709 "RUNX1 MUT" "Shikonin_IC_50" 0.738838457366219 0.929570057037101 0.306303608318886 0.739305955960761 0.968715858066684 -0.256416803575858 0.294981435543831 0.894167310052 -1.04247435330822 "NRAS MUT" "PAC.1_IC_50" 0.72599385639784 0.92544157293946 -0.0969331286159318 0.739313801703366 0.968715858066684 0.0792889419323827 0.33363349590178 0.903569160603576 0.294632659599208 "BRCA2 MUT" "GW.441756_IC_50" 0.850716068289667 0.963551766672686 0.102866643129773 0.739373035215154 0.968715858066684 -0.1791985780977 0.816630753666049 0.977383317127464 0.126889615284494 "CDK6 MUT" "X17.AAG_IC_50" 0.91026192662084 0.981906494633752 -0.0831740208065213 0.739444052354318 0.968715858066684 -0.215524135964292 0.640178533103766 0.955094994589269 0.302391108824972 "FGFR3 MUT" "Roscovitine_IC_50" 0.601547525336684 0.880745626033854 -0.619533103448277 0.73946913492191 0.968715858066684 0.347791059577697 0.832358111458889 0.981482581683432 -0.251683797026763 "BRAF MUT" "ABT.888_IC_50" 0.652223889707364 0.899720466680818 0.0678821891371334 0.739516601458941 0.968715858066684 -0.0465899541319759 0.301872312772793 0.894167310052 -0.173500472731457 "EZH2 MUT" "DMOG_IC_50" 0.751522644612095 0.932942774224212 -0.215500521739134 0.73956599744078 0.968715858066684 -0.202703805071071 0.97087017719565 0.99742775226181 0.0252548956057282 "NRAS MUT" "BMS.708163_IC_50" 0.958104226201985 0.993340772343095 -0.0126569984239559 0.740006794359548 0.968715858066684 0.0837866002045022 0.389286070636368 0.915926348152589 0.243560965443434 "BCR_ABL MUT" "SB.216763_IC_50" 0.0231598878468308 0.277593371444066 -1.65461632093937 0.740119977827374 0.968715858066684 0.302246116011812 0.0898605033279883 0.762226485249154 -1.23532723972567 "BRCA1 MUT" "A.770041_IC_50" 0.955468787725289 0.992745778961198 -0.101314837288135 0.740277459582897 0.968715858066684 -0.488717451942166 0.905158049334447 0.988892684972226 -0.208141685837089 "ALK MUT" "Vinorelbine_IC_50" 0.578142407710799 0.873750949722175 0.797482732758618 0.74031061765639 0.968715858066684 0.349123888946658 0.724510252134891 0.965402608571648 0.699788709526044 "TET2 MUT" "Vinorelbine_IC_50" 0.216978518710543 0.689934201456618 -1.44609518998269 0.740384164089178 0.968715858066684 -0.287888923487131 0.18893832073074 0.851001889249827 -1.85286018456889 "BRCA2 MUT" "VX.702_IC_50" 0.488761101200609 0.841958671689735 0.466066007677553 0.740401920326653 0.968715858066684 0.18390100129182 0.72146461342951 0.965402608571648 0.225387898082386 "ALK MUT" "VX.680_IC_50" 0.673654920504451 0.908401055116919 0.55732030479452 0.740526745549272 0.968715858066684 0.28565929562468 0.603258762670123 0.949657634568742 0.830181657389213 "MLL_AFF1 MUT" "Pazopanib_IC_50" 0.297235684353848 0.748266144511455 -1.39058242956523 0.740542846710505 0.968715858066684 -0.38223197239551 0.1852944427938 0.851001889249827 -1.62380290959898 "MSH6 MUT" "AP.24534_IC_50" 0.840523832177903 0.959424448728358 -0.198283048780488 0.740552732520994 0.968715858066684 0.292998513663738 0.883107985608942 0.988301482344111 -0.13538794764276 "FGFR2 MUT" "AZ628_IC_50" 0.3317785562196 0.772603259108552 1.51847157337884 0.740675849965517 0.968715858066684 -0.395862332249897 0.744234142975143 0.967580650528802 0.53844352322426 "SOCS1 MUT" "Docetaxel_IC_50" 0.801318943996433 0.9507092914502 0.322224803088801 0.740895386570561 0.968715858066684 0.318046155945709 0.843044812467477 0.983031552042661 0.243985976758668 "APC MUT" "AMG.706_IC_50" 0.129140699808722 0.590575980948123 0.365724634986226 0.741201162020272 0.968715858066684 0.0771730489478011 0.955078628910736 0.996100446818628 -0.0153404273339963 "MSH6 MUT" "Vinblastine_IC_50" 0.692501094533665 0.913066921534475 -0.268796695128627 0.741237592889964 0.968715858066684 -0.162553517226608 0.775928197085388 0.972337708041191 -0.180607852908005 "BRAF MUT" "MG.132_IC_50" 0.0754376460847108 0.480779116570693 -0.993970503678556 0.741547393494182 0.968715858066684 0.178146260961526 0.5164108035305 0.939635632721979 0.434118922716422 "BRCA2 MUT" "GNF.2_IC_50" 0.378442562036291 0.795952477739693 0.782979003401363 0.741686804518614 0.968715858066684 0.282106062703741 0.240200996576394 0.875707386589409 1.07525365403642 "FBXW7 MUT" "Salubrinal_IC_50" 0.0309328154426628 0.326264054568038 -1.13606046734954 0.741890479245472 0.968715858066684 -0.14675391836277 0.100642219285204 0.774133667469059 -0.895634154574292 "AKT2 MUT" "GDC.0449_IC_50" 0.986115559660464 0.996887811168928 0.00873191309987053 0.742045105877926 0.968715858066684 -0.147077845357429 0.901875110075247 0.988746233284632 -0.0618086612930512 "KDR MUT" "AG.014699_IC_50" 0.627494072481784 0.891518522789462 -0.404180709363301 0.74205155193082 0.968715858066684 0.242094414295895 0.882048571845118 0.988301482344111 -0.11571525272909 "ERBB2 MUT" "BAY.61.3606_IC_50" 0.0742182308002724 0.479604504293387 0.839021173109242 0.742119130902398 0.968715858066684 0.110844273279215 0.814597197652947 0.977383317127464 0.109893260506883 "ERBB2 MUT" "Epothilone.B_IC_50" 0.530200575997926 0.856734402332693 0.360653435714284 0.742178817916628 0.968715858066684 -0.110652726849624 0.656004175400136 0.958313128388245 0.264789938387846 "PIK3CA MUT" "Embelin_IC_50" 0.702299959420827 0.915500829364901 -0.0782098445577513 0.742190399010622 0.968715858066684 0.0542425530531701 0.513367446894968 0.939635632721979 -0.145174945926343 "FGFR3 MUT" "Bleomycin_IC_50" 0.685773682066284 0.9116697678588 -0.772414581881527 0.742314287162051 0.968715858066684 0.511123794122064 0.733537138614866 0.96672489654949 -0.624382462908679 "CCND1 MUT" "AMG.706_IC_50" 0.291715652255798 0.746611418788718 0.277094883435584 0.742322180802112 0.968715858066684 -0.0800822897410643 0.898420053854632 0.988526046030225 0.0334411360725751 "FLCN MUT" "CCT018159_IC_50" 0.809397700968629 0.952641225877339 -0.197661403508771 0.74235028672863 0.968715858066684 -0.25075106449036 0.169816291737602 0.84067330207935 -1.38510328270665 "STK11 MUT" "CMK_IC_50" 0.757190477349194 0.934762260113025 0.238156783505155 0.742419037493409 0.968715858066684 0.232024555778862 0.668077096581081 0.959230524020512 0.385357739928683 "PDGFRA MUT" "NSC.87877_IC_50" 0.602821446641734 0.880745626033854 -0.261601559792025 0.742726157365919 0.968715858066684 -0.162171964784244 0.726034436343615 0.965402608571648 -0.181577493269384 "GNAS MUT" "X17.AAG_IC_50" 0.90780380666919 0.981281110884746 0.0905591763005773 0.742785864858517 0.968715858066684 -0.225370732297463 0.904743796622678 0.988835108097421 -0.082025519173125 "NF1 MUT" "PAC.1_IC_50" 0.413443025001304 0.812881891750406 0.300322160178937 0.742849902934764 0.968715858066684 -0.101703814732733 0.787008966536439 0.975087420732438 0.103550106855007 "MET MUT" "A.443654_IC_50" 0.559367963747043 0.869446457391816 0.839772224489797 0.742996755720957 0.968715858066684 -0.304652708164014 0.539850946844513 0.944569766818715 0.901216831815533 "NF2 MUT" "Bortezomib_IC_50" 0.0520155178004085 0.40700424104443 -1.40296452797202 0.743234787354942 0.968715858066684 -0.199006391441426 0.82564017824959 0.980029315589217 -0.166951386538781 "IDH1 MUT" "VX.702_IC_50" 0.492823385355281 0.843144766969803 0.72795360687024 0.743363455847106 0.968715858066684 0.282899084899173 0.705551608641747 0.962630898212352 0.375418060303209 "JAK2 MUT" "NVP.BEZ235_IC_50" 0.592057237990392 0.877806399097275 0.339562878423517 0.743496149772456 0.968715858066684 -0.149662344251083 0.846054377031585 0.98378870157398 0.128938838749513 "SMO MUT" "LFM.A13_IC_50" 0.555523574594208 0.867523275183957 -0.461751304347828 0.743663774413629 0.968715858066684 -0.240052772738892 0.495480320813739 0.933639405738697 -0.529233256992979 "PTEN MUT" "AZ628_IC_50" 0.757613372372372 0.934762260113025 0.130218998512766 0.743713771367951 0.968715858066684 -0.104482413097295 0.434054415450967 0.922569292988365 0.313268875789292 "NRAS MUT" "ABT.888_IC_50" 0.986860652385505 0.997417714104435 0.00293220256161872 0.743725123391626 0.968715858066684 0.0511580761512242 0.518005204607045 0.939635632721979 0.122412298888964 "MET MUT" "Shikonin_IC_50" 0.398681913976297 0.805918367644724 -0.525380371915298 0.743804776617737 0.968715858066684 -0.171847392679172 0.225285406154475 0.86643108387559 -0.735280863851175 "SMARCA4 MUT" "AZD6244_IC_50" 0.985279052422956 0.996887811168928 0.0147365584551142 0.743807701692175 0.968715858066684 -0.236482159908764 0.274946770972006 0.883780956691668 -0.911551388941928 "BRAF MUT" "MS.275_IC_50" 0.69386710434023 0.913368820021033 -0.204771385774219 0.743887713299033 0.968715858066684 -0.154259767177401 0.799783044438446 0.976360691959787 -0.177745067104773 "CDH1 MUT" "BMS.708163_IC_50" 0.833803257463503 0.95907353057031 -0.0970179100290237 0.743944223171965 0.968715858066684 -0.153593015888024 0.490778263558791 0.933639405738697 -0.351772995612209 "EGFR MUT" "Elesclomol_IC_50" 0.310739868075852 0.757321835450506 0.470516598814228 0.743944993101815 0.968715858066684 0.126128008633875 0.396507307054438 0.916480913435499 0.38957067409914 "MSH2 MUT" "SB.216763_IC_50" 0.405748964151044 0.808131094556049 -0.496684885396198 0.743950648552729 0.968715858066684 -0.188487306996793 0.3336310535874 0.903569160603576 -0.559010448189803 "FGFR3 MUT" "MG.132_IC_50" 0.57222686821156 0.872389778906173 -0.94717182432432 0.743963719782697 0.968715858066684 0.482812970524627 0.395209432534382 0.916003810456352 -1.32793975779937 "MYCN MUT" "Bleomycin_IC_50" 0.483660786729328 0.839194763643102 0.525657243536802 0.74401784452549 0.968715858066684 0.205097794164952 0.0607962873611263 0.702860976445846 -1.57058135204897 "SMO MUT" "PLX4720_IC_50" 0.645586614604889 0.897070476954727 0.615850168260037 0.744135653670928 0.968715858066684 0.386003966973891 0.909420424585973 0.989774851807356 0.137556349609404 "PIK3R1 MUT" "QS11_IC_50" 0.200901264895679 0.674012093366938 0.892398643233745 0.744310538980749 0.968715858066684 -0.167349211954267 0.252901901300619 0.875707386589409 0.775439270627674 "APC MUT" "XMD8.85_IC_50" 0.776493396097041 0.941591338606299 0.158834638612273 0.744488670689159 0.968715858066684 0.159467015503239 0.401842776884645 0.916589616820582 0.55952212816474 "CDKN2A MUT" "Cisplatin_IC_50" 0.157458375342436 0.632962968719319 -0.204387742549027 0.744498431187126 0.968715858066684 0.0425422408715761 0.4298966100162 0.922428741067589 0.124395199816629 "KDM5C MUT" "AZ628_IC_50" 0.770716831211306 0.939898671414565 0.456306385665525 0.744528688877347 0.968715858066684 0.380230745470629 0.848130003555805 0.98378870157398 -0.257179539093057 "JAK2 MUT" "CEP.701_IC_50" 0.406272834764996 0.80881171162249 0.583295327312534 0.744535797440994 0.968715858066684 -0.16790515325342 0.648546751478567 0.957493413330814 0.316175377916202 "FBXW7 MUT" "SB590885_IC_50" 0.0679762534091268 0.461747350209541 -0.756973518907563 0.744721040932642 0.968715858066684 -0.113823799595994 0.296597307789976 0.894167310052 -0.404699436375077 "SMAD4 MUT" "GNF.2_IC_50" 0.371590721487089 0.791200478908377 -0.428216713297083 0.744842841939438 0.968715858066684 -0.152751434861624 0.459896437433443 0.927837405916949 -0.380878488558267 "BCR_ABL MUT" "Gefitinib_IC_50" 0.00202714653704534 0.0669259791654263 -2.50374288523813 0.744849275040822 0.968715858066684 -0.292144128084838 0.0352987753837233 0.623237423822756 -1.58823915094179 "NF1 MUT" "VX.702_IC_50" 0.207662129064019 0.681036694319629 0.410951062409817 0.744867007822762 0.968715858066684 -0.0873487396826246 0.36449235068521 0.913390679016748 0.292231367108143 "CDKN2C MUT" "Bosutinib_IC_50" 0.533951116657578 0.858279561609675 0.398187872832368 0.74489940385339 0.968715858066684 0.17162423561297 0.838928517323004 0.981704379975756 0.128981588902339 "RB1 MUT" "JW.7.52.1_IC_50" 0.649395849326585 0.898715072993842 -0.201632912836477 0.744988839567308 0.968715858066684 0.0893906566761492 0.0416534784261601 0.658180729724545 -1.07135638568422 "MYC MUT" "RO.3306_IC_50" 0.781417688061251 0.943838793110076 -0.0671481540084383 0.744998233374108 0.968715858066684 -0.0752920062054274 0.636006532652327 0.953101495776253 -0.119776386160469 "KDM5C MUT" "Midostaurin_IC_50" 0.781448783440873 0.943838793110076 -0.260080700692045 0.745345301381481 0.968952271752869 -0.235304105628062 0.48310177602744 0.931761829532683 -0.595592222809175 "CDK6 MUT" "Erlotinib_IC_50" 0.541253285925865 0.861616652986104 0.609649805352803 0.745541172905571 0.968952271752869 0.294413948354509 0.687067762373196 0.961100601384891 0.480442124269762 "SMARCA4 MUT" "Lenalidomide_IC_50" 0.337980094412088 0.775607549993217 0.324587649325627 0.745541358904306 0.968952271752869 0.095993742705633 0.777792034866591 0.972337708041191 0.104587987911254 "RB1 MUT" "X681640_IC_50" 0.519877328415407 0.852599738673405 -0.151289118669691 0.745861307408826 0.968952271752869 -0.0665073408202851 0.365666313941829 0.913948248824328 -0.221518137945467 "SMARCA4 MUT" "BIRB.0796_IC_50" 0.530988254020148 0.856734402332693 0.243178684719536 0.746039224753691 0.968952271752869 0.119835224837681 0.0896208729285462 0.761022269009867 0.741917242875804 "PIK3CA MUT" "BMS.754807_IC_50" 0.67819080848569 0.908722475884341 -0.136527627328093 0.746079186771639 0.968952271752869 0.0900376079323625 0.513530286992772 0.939635632721979 -0.231380710363408 "AKT2 MUT" "AICAR_IC_50" 0.633936101096294 0.89399270048764 0.335317153996103 0.746159043362508 0.968952271752869 0.203886033990967 0.526282374420868 0.941286003360735 0.431927679363918 "MLH1 MUT" "Epothilone.B_IC_50" 0.875727400084902 0.971594429690931 0.106491322123895 0.746303970594142 0.968952271752869 0.126646417270614 0.841251650981606 0.982150602679453 0.133946727884243 "FAM123B MUT" "AKT.inhibitor.VIII_IC_50" 0.861235702046556 0.966384100200122 0.125724764298092 0.746338681491129 0.968952271752869 -0.199418444283102 0.387304287111254 0.915785792511616 0.615587676971354 "MSH6 MUT" "Pyrimethamine_IC_50" 0.469301246025363 0.83190905508009 -0.846539223549482 0.746477264030425 0.968952271752869 -0.320014730881879 0.479943549328389 0.930304161706959 -0.823454606939719 "EP300 MUT" "Roscovitine_IC_50" 0.65490660877537 0.901074441039429 -0.530322068965511 0.74652587423214 0.968952271752869 0.338868499605848 0.649050414909111 0.957493413330814 -0.53993361791809 "BRCA2 MUT" "BI.2536_IC_50" 0.32367447740569 0.765322958956319 1.58687719322032 0.746965636767928 0.968952271752869 0.310380164397718 0.154904645469731 0.836658903934028 2.39988233356857 "EWS_FLI1 MUT" "Pazopanib_IC_50" 0.902683775233675 0.979694707150557 -0.0602746518386729 0.747215243088297 0.968952271752869 0.145213979395998 0.813185809452158 0.977383317127464 0.121530067556034 "MS-HL MUT" "PD.173074_IC_50" 0.294941189718222 0.747036827777118 -0.205665989215794 0.747218206902858 0.968952271752869 -0.0543771519530635 0.989646267335815 0.998596878102629 0.00256451141242857 "BRCA2 MUT" "WZ.1.84_IC_50" 0.344387425668434 0.780249349533262 1.12319530612245 0.747252966610961 0.968952271752869 -0.321554921610901 0.235349435685752 0.869962136993019 1.35701589735891 "CCND3 MUT" "AG.014699_IC_50" 0.936371861985897 0.988343059935435 0.0813557197309419 0.747395033692029 0.968952271752869 0.288815632229038 0.982529218075564 0.998011368051263 -0.0205489897014945 "FLCN MUT" "BMS.708163_IC_50" 0.731704931418536 0.928176068595523 0.241060230425058 0.747404171928791 0.968952271752869 0.228191243181919 0.533305334322007 0.943443271455699 0.541055987476524 "JAK2 MUT" "ABT.888_IC_50" 0.54952481307276 0.864873049004332 0.240716643406592 0.747524421217154 0.968952271752869 0.109329482203651 0.705586736880658 0.962630898212352 0.154796923381322 "MSH2 MUT" "Camptothecin_IC_50" 0.635024258865824 0.89462773886888 -0.405799154077723 0.74753789305091 0.968952271752869 -0.174059974750936 0.999299911076199 0.999751228014461 -0.000666699876119757 "BCR_ABL MUT" "ZM.447439_IC_50" 0.0156141650531428 0.227586688087166 -1.93415983529412 0.747559843154989 0.968952271752869 0.251210682655049 0.342933430419351 0.907180409180092 -0.741562749788976 "NF1 MUT" "Salubrinal_IC_50" 0.15421453451215 0.629901298984863 0.669929435688867 0.747748960701595 0.968952271752869 0.125565075579171 0.170008923604832 0.84067330207935 0.726042721138885 "STK11 MUT" "Methotrexate_IC_50" 0.193554115352884 0.668853734805043 0.656786214553009 0.747856009894613 0.968952271752869 0.12365899895642 0.722232927831924 0.965402608571648 0.153141359279937 "PIK3CA MUT" "Vinblastine_IC_50" 0.687737944233606 0.911748124009352 0.104854511933559 0.747878670032748 0.968952271752869 0.0614892490894645 0.724336200564357 0.965402608571648 -0.0949896157067424 "BRCA1 MUT" "WH.4.023_IC_50" 0.640920601407488 0.896000211845268 1.17495634693878 0.748043369608612 0.968952271752869 0.703081681494642 0.838272495984098 0.981704379975756 0.486720307564779 "APC MUT" "Doxorubicin_IC_50" 0.425779800728021 0.819381892124907 0.286670894304616 0.748052666854682 0.968952271752869 -0.0754486506479646 0.817882783809671 0.977383317127464 0.0960778332433559 "PIK3R1 MUT" "Epothilone.B_IC_50" 0.0579121742115529 0.43286323628399 1.57351814059754 0.748113929832881 0.968952271752869 0.151823434564705 0.0919982804237117 0.767170637035666 1.35850674485754 "MAP2K4 MUT" "MG.132_IC_50" 0.780763994946186 0.943396603961507 -0.331244957482995 0.748125856030787 0.968952271752869 0.339971103472177 0.382428870086157 0.915134825237766 1.12446891212691 "APC MUT" "Methotrexate_IC_50" 0.103294111776406 0.544747628673553 0.689584815239631 0.748518010578329 0.96902449845351 -0.109219878876238 0.143035457664436 0.831473272394224 0.59232186968262 "STK11 MUT" "AZ628_IC_50" 0.868597711211214 0.968770736448595 0.201342718213059 0.748528743147709 0.96902449845351 -0.29134162962414 0.329213206452998 0.902810042912437 1.16787857385895 "EWS_FLI1 MUT" "Metformin_IC_50" 0.815716404874717 0.954589193792642 -0.0909129794330194 0.748667826294543 0.96902449845351 0.125213216942414 0.290747599040937 0.891022884087089 0.466364749360157 "KDM5C MUT" "AZD.0530_IC_50" 0.609023988814428 0.884360685431551 -0.520471445762714 0.748817744366875 0.96902449845351 -0.28312377759864 0.81842781830855 0.977383317127464 -0.219098564053998 "FBXW7 MUT" "PD.0325901_IC_50" 0.769323260664375 0.939026921105046 0.14361564348641 0.748897500404567 0.96902449845351 -0.148056872295932 0.542594268413524 0.945765861891114 0.279183250048632 "SETD2 MUT" "PF.562271_IC_50" 0.575709415475369 0.872895290383193 0.608340584482773 0.74907528673094 0.96902449845351 0.284408069105967 0.458007153540535 0.926551601501934 0.792570247780215 "AKT2 MUT" "JNK.9L_IC_50" 0.19729367882912 0.673909677569775 -0.67290428347827 0.749182551444867 0.96902449845351 -0.130146678714953 0.188674827279794 0.851001889249827 -0.688671864603431 "MAP2K4 MUT" "BMS.509744_IC_50" 0.717259627841779 0.921306561002511 -0.363970850340136 0.749224945703179 0.96902449845351 -0.238456426907204 0.885092067329802 0.988301482344111 -0.173847943273274 "MAP2K4 MUT" "Bicalutamide_IC_50" 0.795573625903813 0.948769890110348 -0.0450842962356782 0.749299887981169 0.96902449845351 0.052913058222012 0.331049334535272 0.902810042912437 0.174195732370504 "PTEN MUT" "Doxorubicin_IC_50" 0.883268230012932 0.973927829424842 -0.0336311687470111 0.749546737303427 0.96902449845351 0.0463959658846705 0.510154179604398 0.938422873866617 -0.155458069080546 "PIK3R1 MUT" "Erlotinib_IC_50" 0.4112888911139 0.812480994891775 0.637263382352944 0.749582915527681 0.96902449845351 0.223016062317588 0.459407273528771 0.927632358897555 0.555164957977291 "PIK3CA MUT" "Vorinostat_IC_50" 0.119760422098852 0.57772531703417 0.301125337254722 0.749603426938801 0.96902449845351 0.047818215332307 0.879682070304496 0.988301482344111 -0.0291109468369176 "IDH1 MUT" "PLX4720_IC_50" 0.69234148818864 0.913066921534475 -0.529864458891015 0.749750561355026 0.96902449845351 -0.376993731394467 0.710091490611191 0.962630898212352 -0.453961936191037 "CDK6 MUT" "NSC.87877_IC_50" 0.908183770012126 0.98145291573104 0.0433721349621875 0.749759565043482 0.96902449845351 0.117810332354993 0.834217380815143 0.981482581683432 0.0845288743296587 "FGFR2 MUT" "ZM.447439_IC_50" 0.659055647991629 0.902400992643984 0.499558298828121 0.74984532500573 0.96902449845351 -0.289385629684449 0.413851590306057 0.921714070263062 -1.23243341050801 "CDKN2a(p14) MUT" "KIN001.135_IC_50" 0.438962387653963 0.824179170555842 -0.0748859730150497 0.749947894376426 0.96902449845351 0.0325759144269273 0.840093452217142 0.981985848511457 -0.020870309755281 "NF1 MUT" "Vinblastine_IC_50" 0.700142442831711 0.915410639012359 0.149828282768513 0.750188084963436 0.96902449845351 0.0900939229293604 0.817130905562752 0.977383317127464 -0.0896807795482876 "SETD2 MUT" "Bexarotene_IC_50" 0.679904924437201 0.909220155851267 -0.469388836521744 0.750213583732809 0.96902449845351 -0.324871990307072 0.851020374718568 0.98448768371442 -0.204287523672698 "MLL_AFF1 MUT" "MG.132_IC_50" 0.341200883419628 0.778707276763076 1.5954427027027 0.750254751870999 0.96902449845351 0.481419564545817 0.724336287365104 0.965402608571648 0.552467322331029 "PTEN MUT" "Docetaxel_IC_50" 0.256301425443601 0.720320556760956 -0.25738384583687 0.750722771403471 0.969097914919129 0.0551986976244907 0.631830850219383 0.952523560833852 -0.113702598567298 "STK11 MUT" "Nilotinib_IC_50" 0.214953572554665 0.688556914357028 0.442151807961268 0.750884671789836 0.969097914919129 0.0920021797638545 0.395858870006922 0.916003810456352 0.291050149814514 "STK11 MUT" "Cytarabine_IC_50" 0.471188844269598 0.832609597697904 0.311252527523757 0.750894832756278 0.969097914919129 0.103875230258555 0.463142825866505 0.929276781658587 0.313494565613655 "IDH1 MUT" "AUY922_IC_50" 0.718729092051538 0.92132587844031 -0.483045629565221 0.750914466165865 0.969097914919129 0.284472117587589 0.784566815061296 0.974508795043269 0.352444431338592 "SMARCA4 MUT" "Embelin_IC_50" 0.57767434788438 0.873750949722175 0.242633310311598 0.750961223483205 0.969097914919129 0.109838852473656 0.637171286348235 0.953127538160464 0.228495243081199 "MLL_AFF1 MUT" "NU.7441_IC_50" 0.395698585269784 0.804008910182289 -0.860637625246553 0.751075779073753 0.969097914919129 0.288218950980387 0.996838893171323 0.999545005862799 0.00393470764219832 "FGFR3 MUT" "AZD8055_IC_50" 0.790509344473639 0.94790644179192 0.267178382178221 0.751141551911914 0.969097914919129 0.247831987030294 0.933456641161548 0.99465624694452 0.08099410256085 "TSC1 MUT" "AS601245_IC_50" 0.278492357685322 0.736660995953974 1.38207956173915 0.751196986238956 0.969097914919129 0.324331402999169 0.221048476068358 0.864815645798718 1.53817203859937 "IDH1 MUT" "PAC.1_IC_50" 0.784490320871797 0.94558340657742 0.334355989565217 0.751392240655366 0.969097914919129 0.322466229319679 0.950417392316766 0.995668765770473 -0.0737522015658239 "MSH6 MUT" "CCT007093_IC_50" 0.901746223918856 0.979694707150557 -0.062738677130046 0.751472407779199 0.969097914919129 -0.161262467336702 0.959179002829262 0.99641548698706 0.0262828301116627 "FGFR2 MUT" "IPA.3_IC_50" 0.231806161189299 0.704757001699372 1.2376439546248 0.751511917582259 0.969097914919129 -0.279864477862898 0.136724615818988 0.830541253822459 1.64945767706722 "FGFR2 MUT" "Vinorelbine_IC_50" 0.00248650899614658 0.0766759944263118 3.06105542387541 0.751805356263521 0.969160627841245 0.239154414061699 0.0460345590876803 0.672422564568567 2.2919771437152 "TP53 MUT" "SB.216763_IC_50" 0.547700521491169 0.863742907875179 0.081851183020536 0.751878786791052 0.969160627841245 0.0436395333663996 0.749513151104224 0.968780465757047 -0.0449198341001063 "MAP2K4 MUT" "BMS.754807_IC_50" 0.885452059704946 0.974449243426767 -0.0930368127386787 0.751986950249152 0.969160627841245 0.17034211112285 0.602039563935274 0.949657634568742 -0.363115439053406 "MSH2 MUT" "RDEA119_IC_50" 0.835931709639738 0.959122768755193 0.184372718000002 0.752196452818172 0.969160627841245 0.253878746758748 0.385128224461908 0.915331032347709 -0.666261601213574 "MAP2K4 MUT" "AZD.0530_IC_50" 0.995656735976345 0.998977896287767 -0.00638686599099112 0.752269350077071 0.969160627841245 0.319991844938118 0.467013657049152 0.929276781658587 -0.978050745256799 "RUNX1 MUT" "Nutlin.3a_IC_50" 0.661553572127506 0.902497277122025 0.472943664709723 0.752409900592146 0.969160627841245 0.31096828725153 0.890846817428874 0.988301482344111 0.142306856843498 "MSH6 MUT" "Axitinib_IC_50" 0.983357017579235 0.996723172778267 -0.0141153628899837 0.752429842426236 0.969160627841245 0.180148267066159 0.794436492548598 0.975460927965106 0.154027733535559 "MET MUT" "GDC.0449_IC_50" 0.342628836107145 0.779440739135111 0.338535177165357 0.75243356930136 0.969160627841245 0.100492246570355 0.658566926068299 0.958313128388245 0.156116575040698 "AKT2 MUT" "SB.216763_IC_50" 0.600286329924375 0.880698848449586 0.313099495743287 0.75309487894421 0.96982908291778 0.181290019744206 0.669618343252374 0.959230524020512 -0.248100323292612 "TP53 MUT" "Sorafenib_IC_50" 0.371513627931812 0.791200478908377 0.200553039434524 0.753251443040481 0.96982908291778 0.0703555110336126 0.838482784916771 0.981704379975756 0.0514036043172943 "EP300 MUT" "PAC.1_IC_50" 0.568718232382522 0.872389778906173 0.569390814169562 0.753280150204577 0.96982908291778 -0.263402946040952 0.955812837277496 0.996100446818628 0.0530921510956806 "MAP2K4 MUT" "X17.AAG_IC_50" 0.959372992635354 0.993456347206305 0.0326504271844656 0.753431303728878 0.969883085724912 0.17702000866498 0.386328530098329 0.91566150942174 0.53938534003545 "BRCA1 MUT" "GDC0941_IC_50" 0.682856582871583 0.910084943794605 0.372528977319583 0.753643011062622 0.969949251607695 0.230850159033271 0.822850338720196 0.977953923255225 0.201981245090959 "CDKN2a(p14) MUT" "Etoposide_IC_50" 0.0587762298100168 0.4379124974352 -0.399328903010632 0.753701135609132 0.969949251607695 0.0452826832748765 0.948889611219101 0.995668765770473 -0.0143666113513911 "FBXW7 MUT" "Imatinib_IC_50" 0.56935734089921 0.872389778906173 -0.25448902422145 0.753885466946612 0.970045904368714 -0.141063206042226 0.847928589785277 0.98378870157398 -0.0937045626908391 "NOTCH1 MUT" "Vorinostat_IC_50" 0.00633512086743839 0.138397665983245 -0.933055334389409 0.754221950456413 0.970247006095552 -0.0852515590081263 0.836333182117917 0.981626636221501 -0.0701665370381814 "MDM2 MUT" "Gefitinib_IC_50" 0.635851292142062 0.894862632072096 0.245431290944124 0.75426025561127 0.970247006095552 -0.145874756257767 0.670338037742747 0.95927684711462 0.197744479907089 "CDKN2A MUT" "Bexarotene_IC_50" 0.0357811204423245 0.347105523744792 -0.283172176874002 0.754480985478225 0.970362113689843 0.0395725658813452 0.342441953995726 0.907180409180092 0.140205728995392 "MSH6 MUT" "Camptothecin_IC_50" 0.797871193526039 0.949524851900765 -0.218962550355775 0.754847359106386 0.970362113689843 0.168505156644201 0.909140499775601 0.989712770103838 -0.0856542161350521 "NF2 MUT" "GW.441756_IC_50" 0.553391286703749 0.866799981376517 -0.160513826302961 0.75505029681856 0.970362113689843 -0.0830002931968738 0.718397370882845 0.964721180904622 -0.10353736524439 "CCND1 MUT" "GDC0941_IC_50" 0.537500549083781 0.86087328699965 0.229890603879312 0.755079689457108 0.970362113689843 0.0943032892395671 0.843326218791346 0.983031552042661 0.0791055415125727 "CDKN2A MUT" "Bicalutamide_IC_50" 0.22003407294023 0.692830939023895 -0.0639692557968341 0.755179293096406 0.970362113689843 0.0162804245590224 0.147581806804181 0.831473272394224 0.0809840165223323 "PIK3R1 MUT" "JNK.Inhibitor.VIII_IC_50" 0.917543559835472 0.984975746996111 0.042140467244701 0.755378410504497 0.970362113689843 -0.121035053158096 0.874334680636702 0.98777404048288 -0.0645975187115766 "SMARCA4 MUT" "AZD.2281_IC_50" 0.590838538957751 0.876991017840199 0.25707501 0.755598527342407 0.970362113689843 -0.111749562719773 0.903872977019424 0.988746233284632 0.0579811878676928 "FLCN MUT" "GW843682X_IC_50" 0.440527587581601 0.824500931653809 1.09097514625851 0.755716797204712 0.970362113689843 0.22677431527309 0.378020189744496 0.914597095447912 2.28015992392654 "FBXW7 MUT" "VX.680_IC_50" 0.0631726397354328 0.450893824743909 -1.64880674370886 0.755735492794687 0.970362113689843 -0.182974741255593 0.187876327065289 0.851001889249827 -1.24077222142723 "EWS_FLI1 MUT" "Dasatinib_IC_50" 0.0734197879915499 0.477424621155859 2.14497336204144 0.755807093166042 0.970362113689843 0.340136181458492 0.139444931892606 0.831473272394224 1.77637477880829 "CDK4 MUT" "GDC.0449_IC_50" 0.232570223590117 0.705174515433194 0.465469156862741 0.755824603633368 0.970362113689843 0.108247159931533 0.31487022836405 0.900294798053993 0.407160272268277 "CDK6 MUT" "CMK_IC_50" 0.704315895267172 0.915500829364901 0.376092277588169 0.755874331839189 0.970362113689843 -0.280875371595987 0.52451671587097 0.940554660491705 0.78990964213377 "CDK6 MUT" "CCT007093_IC_50" 0.770809674308654 0.939898671414565 0.10515084841629 0.755990695359676 0.970362113689843 0.1119717655441 0.853232052982164 0.984631915507353 0.0672748441928838 "FBXW7 MUT" "ATRA_IC_50" 0.24210239013799 0.711340033600749 -0.429987832569793 0.756071810520873 0.970362113689843 0.0903038278634677 0.987361265113478 0.998124818853736 -0.00541817332400179 "PTEN MUT" "S.Trityl.L.cysteine_IC_50" 0.770282675450056 0.939810474058518 -0.0960812116935482 0.756169875709831 0.970362113689843 -0.0567239243453097 0.979798757975462 0.997827228172038 -0.00916070323364415 "EZH2 MUT" "AS601245_IC_50" 0.957502498793189 0.993340772343095 0.0365032671679204 0.756201725446447 0.970362113689843 -0.169744923478762 0.506355413869113 0.935912793170426 -0.484446145511543 "MSH6 MUT" "XMD8.85_IC_50" 0.601155275109238 0.880741900288913 -0.479034724137935 0.75625861130423 0.970362113689843 -0.245972532989457 0.760807640446671 0.969901216545994 -0.272492653574798 "SMAD4 MUT" "GSK.650394_IC_50" 0.272004591358585 0.734000646544246 -0.435371487415056 0.756316467848338 0.970362113689843 -0.0821557736652585 0.358139283876995 0.91161229252998 -0.389444345641648 "BRAF MUT" "KU.55933_IC_50" 0.951385300598152 0.992278667599787 0.0109256227472964 0.756494377170411 0.970450175307009 -0.0548327400970022 0.821831377115304 0.977589667849051 -0.0474514227586992 "BRCA2 MUT" "CHIR.99021_IC_50" 0.856371145898283 0.96514911547635 0.106567239583335 0.756670240963702 0.970535587810317 -0.173791314564677 0.584996062718439 0.949294892873838 -0.313284771559119 "FLT3 MUT" "PD.0332991_IC_50" 0.419809810727449 0.814579621820073 0.920592491046805 0.756866411140824 0.970562033347223 0.285679238624654 0.0834302015857528 0.746428921711055 1.85332144300515 "EZH2 MUT" "Embelin_IC_50" 0.825185136664126 0.957177484110155 0.120250984962408 0.75705310285126 0.970562033347223 0.133980907339317 0.903088639861502 0.988746233284632 0.0706056795267576 "STK11 MUT" "Metformin_IC_50" 0.971396773955683 0.995220468612913 0.0112460474308305 0.757352537901972 0.970562033347223 -0.0903929624915167 0.587686968046465 0.949294892873838 0.178157155369249 "GNAS MUT" "RDEA119_IC_50" 0.529741168468249 0.856477574579742 0.523740792585168 0.757375604936016 0.970562033347223 0.232565613983033 0.677759820671824 0.960917140387367 0.295764999183109 "CDKN2a(p14) MUT" "Sorafenib_IC_50" 0.113812980403001 0.565625673731983 -0.36423540802851 0.757424099882423 0.970562033347223 0.0729995503897021 0.724322396547958 0.965402608571648 -0.0952830450530334 "CDH1 MUT" "Mitomycin.C_IC_50" 0.641244823132579 0.896094514063559 0.346871074921755 0.757768355297131 0.970562033347223 -0.182059212752562 0.844824096730888 0.98346871189763 -0.151693538116017 "GNAS MUT" "AZD6482_IC_50" 0.940541369127407 0.989446598697723 -0.0467844527972033 0.757780902586526 0.970562033347223 -0.163214342059576 0.671309254855001 0.960241983012847 -0.261938887585719 "TP53 MUT" "ZM.447439_IC_50" 0.564313382072874 0.871766547058339 0.0862319661568891 0.757825504857709 0.970562033347223 -0.0387598466408793 0.804814907572355 0.976878758490379 -0.0376053754214323 "CDK4 MUT" "Roscovitine_IC_50" 0.963124656284838 0.994159243759316 -0.0548655172413796 0.75787857249002 0.970562033347223 0.325838415350004 0.665037738651179 0.959206771190239 0.516651473189506 "FAM123B MUT" "Shikonin_IC_50" 0.806999333903207 0.952641225877339 0.224454436741764 0.757898324527505 0.970562033347223 -0.23816353645232 0.81842615502244 0.977383317127464 -0.20860690053057 "FLCN MUT" "NVP.TAE684_IC_50" 0.80823558531007 0.952641225877339 0.345732033670031 0.758030340200437 0.970562033347223 -0.359331143810584 0.302552951999354 0.894167310052 2.59635142014622 "KIT MUT" "ABT.263_IC_50" 0.932438524304463 0.98681842896288 -0.0925808607843151 0.758207868884711 0.970562033347223 -0.302895379122895 0.374397874549751 0.913948248824328 -0.848273860355094 "VHL MUT" "VX.702_IC_50" 0.52692721661111 0.855121165130409 0.337734874517378 0.75821991013204 0.970562033347223 0.135180629125518 0.890968221714115 0.988301482344111 -0.0737982040805994 "BRCA2 MUT" "PHA.665752_IC_50" 0.734125057522126 0.928593402067957 0.330189026845634 0.758220852084566 0.970562033347223 -0.300072245277162 0.862002185045738 0.985636848898056 0.175414521869313 "MSH6 MUT" "Bryostatin.1_IC_50" 0.759524515711034 0.935293569610329 -0.137385440026363 0.758360239238453 0.970600559832353 -0.129944835486251 0.570438287987542 0.949294892873838 -0.241783651746361 "SMO MUT" "JNK.9L_IC_50" 0.653988803380341 0.900904870244158 -0.436039350000007 0.758565097781031 0.970633331078883 0.232620908332398 0.558605188836263 0.94928677421639 -0.562003517037644 "JAK2 MUT" "KIN001.135_IC_50" 0.832085265674679 0.958611936552287 0.0956136261261266 0.758805817087864 0.970633331078883 0.134294409300287 0.834738383400251 0.981626636221501 0.10896734637334 "EZH2 MUT" "CCT018159_IC_50" 0.806663294313912 0.952641225877339 0.173883715596329 0.758957202673296 0.970633331078883 0.201465429028405 0.921604756837285 0.993931766508607 -0.0704379810068461 "EGFR MUT" "S.Trityl.L.cysteine_IC_50" 0.461565067615406 0.829117994638435 0.494061220279718 0.759156317997097 0.970633331078883 0.111437977470605 0.275654502610829 0.883780956691668 0.752008366827258 "CDKN2a(p14) MUT" "Bicalutamide_IC_50" 0.0963364262081784 0.530089096130627 -0.0894268695652169 0.759214072206323 0.970633331078883 -0.0164531169432745 0.809085330966275 0.977383317127464 0.0136035389560366 "CDH1 MUT" "GSK.650394_IC_50" 0.266928712740484 0.730537410739056 0.77580461697966 0.759228834636744 0.970633331078883 -0.140518410949591 0.310144250669904 0.89718581932126 0.756090864266401 "KRAS MUT" "JNK.Inhibitor.VIII_IC_50" 0.219473918163424 0.692453909775927 0.165258127406003 0.759251649501094 0.970633331078883 0.0410220666262727 0.773691071339541 0.971324626034276 -0.045346393188739 "PTEN MUT" "BX.795_IC_50" 0.0985249871544071 0.536152212572481 -0.3379054360232 0.759460987254979 0.970633331078883 -0.049440469058642 0.952896746763555 0.99568364368633 0.0116571144555801 "KIT MUT" "BIRB.0796_IC_50" 0.667938562207182 0.905919726780999 -0.261787715105162 0.759519092402385 0.970633331078883 -0.178879358452031 0.706793262323575 0.962630898212352 -0.228811918778309 "NF2 MUT" "KU.55933_IC_50" 0.798372705436944 0.949557787195058 0.0698847022587268 0.759527283368399 0.970633331078883 -0.0752955172761426 0.31456017804928 0.900294798053993 0.289293784113716 "KDR MUT" "RDEA119_IC_50" 0.681579743044455 0.909861476478352 0.555722436507933 0.759650394852813 0.970633331078883 0.374766405454607 0.429961548548314 0.922428741067589 0.924558459066017 "MLLT3 MUT" "GW843682X_IC_50" 0.527232238131613 0.855121165130409 0.495832560975611 0.759755240771135 0.970633331078883 0.122739157528359 0.731739150112388 0.966619666247139 0.293942422400083 "MLH1 MUT" "BMS.536924_IC_50" 0.144931423892311 0.619761064904019 1.28908687975779 0.759806656644566 0.970633331078883 -0.202279742372198 0.0998313265674024 0.774133667469059 1.39906506824305 "CDK6 MUT" "RO.3306_IC_50" 0.396811762224523 0.804769413180176 0.41868087128713 0.760071267284209 0.970822541609853 0.143748504196042 0.428889345902735 0.922428741067589 0.390005628871051 "TP53 MUT" "BI.2536_IC_50" 0.0734423757325681 0.477424621155859 -0.49041084283315 0.760282073503756 0.970822541609853 -0.0530516669056766 0.0879785538712122 0.755673367551674 -0.533267449248724 "CDKN2A MUT" "FH535_IC_50" 0.0149977352728324 0.222362081732929 -0.324537927015089 0.760728192451221 0.970822541609853 -0.0367033670084403 0.90059791025402 0.988704788932507 -0.0183079102065025 "HRAS MUT" "Embelin_IC_50" 0.858518493489246 0.965860494131998 0.114628304195804 0.760848866398189 0.970822541609853 -0.157094541294039 0.349475570622672 0.909999728614578 0.595342584328865 "CDK4 MUT" "PF.562271_IC_50" 0.991880879729986 0.998386941916174 -0.00556011062717747 0.760856312977701 0.970822541609853 0.136188303935092 0.611465109058711 0.949930222127033 0.28922410504888 "ALK MUT" "Etoposide_IC_50" 0.907522074277509 0.981251818741413 0.201529748275861 0.761027696073353 0.970822541609853 -0.343508318297881 0.57114241091706 0.949294892873838 -1.31107449148607 "EP300 MUT" "Epothilone.B_IC_50" 0.58524514608389 0.876506729771444 -0.737298509872233 0.761085298567251 0.970822541609853 0.235162110686231 0.63704655769934 0.953101495776253 -0.618505516782907 "BRCA2 MUT" "PD.0332991_IC_50" 0.286138014729181 0.741088279034661 1.05490433540371 0.761150294781715 0.970822541609853 -0.241313493575847 0.989826406703912 0.998596878102629 0.0118587035208724 "CCND3 MUT" "PF.4708671_IC_50" 0.696262428609766 0.914265261478389 -0.325037331838568 0.761156284162783 0.970822541609853 -0.250030802653731 0.602616750116368 0.949657634568742 -0.437252871213117 "STK11 MUT" "Bosutinib_IC_50" 0.515972665332308 0.852353345422823 0.25421142592259 0.761185357512819 0.970822541609853 -0.0979074623028645 0.550050431304409 0.947060194029534 0.231335238593452 "KDM6A MUT" "BMS.754807_IC_50" 0.581483275311333 0.876022556071237 -0.282060752226792 0.761396369509548 0.970822541609853 -0.129912262555742 0.464314983760748 0.929276781658587 -0.388926395608028 "KRAS MUT" "GDC.0449_IC_50" 0.31385086407046 0.759691884385325 0.145195874504341 0.761536963388063 0.970822541609853 -0.0414584860833687 0.859758718420203 0.985479880500142 0.0293159695986343 "JAK2 MUT" "LFM.A13_IC_50" 0.996171439254108 0.998977896287767 -0.00201812030075195 0.761694110370253 0.970822541609853 -0.120068821271585 0.573673918025075 0.949294892873838 0.256196208503356 "KIT MUT" "Bortezomib_IC_50" 0.234641392654403 0.707962074581044 -1.89642073129252 0.761752063711209 0.970822541609853 -0.407408203900093 0.879804590033927 0.988301482344111 -0.231731267912072 "KIT MUT" "KIN001.135_IC_50" 0.907030270771404 0.981251818741413 -0.0643930976430971 0.761864646739602 0.970822541609853 0.169634864098576 0.529274336969956 0.943054040048671 0.32799856495396 "NF1 MUT" "Pazopanib_IC_50" 0.403481094025863 0.807711061141052 0.334872429053525 0.761885315748499 0.970822541609853 -0.104206940193857 0.768367654100629 0.969901216545994 0.116705813920758 "CDKN2a(p14) MUT" "VX.702_IC_50" 0.80363897309538 0.951995809685991 0.0334659794478526 0.761886815824067 0.970822541609853 -0.0345000416609089 0.695405786335602 0.961100601384891 -0.0546885588199949 "PIK3R1 MUT" "Doxorubicin_IC_50" 0.0625005759616735 0.449811681617198 1.29128943233744 0.761922431597869 0.970822541609853 0.13082636698113 0.0989872737634628 0.774133667469059 1.08435885070989 "TSC1 MUT" "BX.795_IC_50" 0.741913391521881 0.929570057037101 -0.372746226720644 0.76245597974377 0.971197474476552 -0.26504567617636 0.879190511209064 0.988115784617527 -0.151590915622258 "SMARCB1 MUT" "Epothilone.B_IC_50" 0.645981122156238 0.897100601386951 -0.759430744347833 0.762523629297735 0.971197474476552 0.284114670290193 0.582576312045207 0.949294892873838 -0.897537858353779 "APC MUT" "AS601245_IC_50" 0.637068072980228 0.895268363706423 -0.15690272669266 0.762544757293661 0.971197474476552 -0.0830893653156773 0.836594534905738 0.981626636221501 -0.0825572132957564 "PIK3CA MUT" "Gemcitabine_IC_50" 0.820389517755778 0.955901247335223 -0.131521639331493 0.762832519213656 0.971348924357307 0.118012136841757 0.334849645102838 0.904165308044483 -0.573980699529575 "MLLT3 MUT" "AMG.706_IC_50" 0.653908168050323 0.900904870244158 -0.137938353494624 0.762882417226913 0.971348924357307 -0.085302364040913 0.557382457936098 0.949136321936116 -0.174956067446426 "EGFR MUT" "Bicalutamide_IC_50" 0.583374934527456 0.876506729771444 -0.072391269816355 0.763227912421071 0.971649525546378 -0.0380270987844533 0.415464513060536 0.92211126027385 0.10590002883628 "CTNNB1 MUT" "BI.D1870_IC_50" 0.990613583652395 0.998036562927507 -0.00531698488476601 0.763494442010951 0.971849525512291 0.117548702632495 0.152034503928535 0.832065593775825 -0.669716791933463 "MYCN MUT" "BMS.536924_IC_50" 0.257215638256593 0.72159917612758 0.633273216356108 0.763750737639714 0.971937457925218 -0.126518248262328 0.142667526324258 0.831473272394224 -0.935619730352153 "MLLT3 MUT" "WH.4.023_IC_50" 0.86335413156211 0.967259478252192 -0.196618048951048 0.763881795556562 0.971937457925218 -0.296002964879536 0.826984666688592 0.980698467734194 -0.245959314310763 "CDH1 MUT" "ATRA_IC_50" 0.89382721915316 0.976022725555062 -0.0820243629343639 0.763891842846303 0.971937457925218 -0.147541178644542 0.31505223283871 0.900294798053993 -0.581786149429422 "VHL MUT" "PD.173074_IC_50" 0.758882546494191 0.934762260113025 0.157559832015805 0.764015310516832 0.971955303351953 0.132720377181874 0.385247393472427 0.915331032347709 0.444516970787784 "MLH1 MUT" "Erlotinib_IC_50" 0.122235160471558 0.580982694522287 0.951420789962822 0.764330091022488 0.972028491295966 0.168504005322803 0.347701798274849 0.909999728614578 0.574693167281879 "NF2 MUT" "PD.0332991_IC_50" 0.551489659564135 0.865580796066258 -0.267982988115632 0.764381614516246 0.972028491295966 -0.108727878326247 0.729083472574502 0.965407830614903 -0.156384693588905 "EGFR MUT" "BMS.754807_IC_50" 0.993939222402961 0.998977896287767 -0.00372131368701909 0.764446856564671 0.972028491295966 -0.122112830119075 0.942779038065569 0.995314665488626 0.0362688487036489 "NF2 MUT" "X17.AAG_IC_50" 0.510550632823784 0.849393770898084 -0.31447597443744 0.764523086398638 0.972028491295966 0.127230461978852 0.483676071940829 0.932593833023556 0.313871471297616 "NRAS MUT" "Nutlin.3a_IC_50" 0.0790384555364201 0.48847635603267 -0.588828443394443 0.764631934859543 0.972028491295966 -0.0955804365122887 0.621739142559269 0.950496524771391 -0.18379927992936 "KDR MUT" "PF.4708671_IC_50" 0.890414774106329 0.975801867105169 -0.09378093632959 0.764779605007113 0.972028491295966 -0.201440690593402 0.931086294922013 0.99422596912377 -0.060371323483749 "GNAS MUT" "AICAR_IC_50" 0.39328339288599 0.803073858340542 0.556942885044647 0.764896727980059 0.972028491295966 0.174449283534689 0.384567420644117 0.915331032347709 0.545322950537619 "SMO MUT" "Bosutinib_IC_50" 0.940098382129314 0.989446598697723 0.0956813923809538 0.764971019091055 0.972028491295966 -0.310893792930617 0.911652952858466 0.990339041794625 -0.13018957734143 "NF2 MUT" "QS11_IC_50" 0.968763673721654 0.994856543446662 -0.0170720706577603 0.765169101674151 0.972028491295966 0.096606631088212 0.943466348308605 0.995314665488626 0.0325325342153033 "NF1 MUT" "Bexarotene_IC_50" 0.538074493575586 0.860998762866154 0.210421498744311 0.765397848826763 0.972028491295966 -0.0916365808280183 0.889201814275611 0.988301482344111 -0.0492199439984996 "KDM6A MUT" "SB590885_IC_50" 0.469852619595356 0.832012966658205 -0.315743262436078 0.765471929320005 0.972028491295966 0.110147706151862 0.927623744471501 0.994186152404781 0.0358389945524073 "EGFR MUT" "GSK269962A_IC_50" 0.405227760846434 0.807904911469051 0.618630372822302 0.765478493347862 0.972028491295966 0.205483013587522 0.183131423502816 0.851001889249827 0.993999613849219 "CCND2 MUT" "DMOG_IC_50" 0.93375602672463 0.987459784870378 -0.0861191709844554 0.765495695093344 0.972028491295966 -0.276307635283292 0.698265342368902 0.961100601384891 -0.462968637134417 "CDK6 MUT" "PD.0332991_IC_50" 0.547451049463903 0.863582852078971 0.398875121106462 0.76566757790769 0.97210775688323 -0.157681827386558 0.653918498152884 0.958313128388245 0.277924295754894 "CDKN2a(p14) MUT" "SB590885_IC_50" 0.171129419791658 0.649721929411943 -0.230085420867587 0.766134039303286 0.972410827902637 -0.0436004445713875 0.697647176577806 0.961100601384891 -0.064131247805489 "EGFR MUT" "BMS.536924_IC_50" 0.397839610847761 0.805826318300581 0.671895494773522 0.766147681718412 0.972410827902637 0.173098340665407 0.122644407947538 0.810576117427226 1.17385487777508 "MDM2 MUT" "PAC.1_IC_50" 0.258901192236043 0.723189643810247 0.621323209876543 0.766314209995403 0.972410827902637 0.136892680379381 0.493693032229459 0.933639405738697 0.362134772075543 "BRAF MUT" "GSK269962A_IC_50" 0.773613056010925 0.94153218611416 -0.157679263536539 0.76634426128708 0.972410827902637 -0.166059057191118 0.683086312380561 0.961100601384891 0.285970255246291 "KDM6A MUT" "PF.562271_IC_50" 0.418334145894216 0.814099702076568 -0.276001611153554 0.766602019713574 0.972455769701355 -0.0827561486053439 0.59039904572472 0.949294892873838 -0.190892669098779 "RB1 MUT" "Rapamycin_IC_50" 0.672674308692807 0.907767897812007 -0.209965409736675 0.766621237193888 0.972455769701355 0.12958895911735 0.180005536146783 0.848722027112292 -0.788159924289876 "PDGFRA MUT" "Embelin_IC_50" 0.668894011694321 0.906523381330271 -0.274987919580421 0.766809732496398 0.972455769701355 0.152331643185754 0.851972002935838 0.984631915507353 0.120647574242045 "KIT MUT" "Cyclopamine_IC_50" 0.836828448229711 0.959212493377535 -0.216023287671236 0.766817673147009 0.972455769701355 0.295264214032414 0.680578032174972 0.961100601384891 0.436487871375706 "PTEN MUT" "QS11_IC_50" 0.763882800351453 0.936244886169491 -0.0691947538259206 0.767071761782901 0.972639108565668 -0.0512827642017149 0.476684627331837 0.929855889225741 -0.173208341674045 "APC MUT" "AP.24534_IC_50" 0.0838159517490649 0.500295367140933 0.869129690909098 0.767256798793071 0.972734850832442 0.140976697563295 0.307745634458665 0.89718581932126 0.589164865105316 "CDKN2a(p14) MUT" "Gemcitabine_IC_50" 0.0343788888830991 0.342467578391929 -0.742756733907817 0.767416131720582 0.972797982559305 -0.072949687435752 0.805085536173209 0.976878758490379 0.0907213287019896 "CDKN2A MUT" "Sunitinib_IC_50" 0.00505145561443494 0.122239720195631 -0.794345972457107 0.767879638781353 0.973246620810218 -0.0661243367480983 0.19471957437675 0.851001889249827 -0.373735065369317 "RB1 MUT" "Vinorelbine_IC_50" 0.681871594778975 0.909861476478352 0.106421548860074 0.76800774922951 0.973270094307546 0.0574994175800736 0.580908414165632 0.949294892873838 -0.160668480229408 "CCND1 MUT" "Midostaurin_IC_50" 0.275103961214692 0.73402283606276 0.401686009809813 0.768569992731325 0.973590705992338 0.084264242209864 0.667595557338913 0.959230524020512 0.154161089932225 "CCND3 MUT" "RO.3306_IC_50" 0.703515056763012 0.915500829364901 -0.396292109374996 0.768771090120977 0.973590705992338 -0.291827972308893 0.750903742036088 0.968780465757047 -0.328545856703062 "MS-HL MUT" "Thapsigargin_IC_50" 0.316330390285219 0.761258739353268 -0.369791728289401 0.768806660629607 0.973590705992338 0.0834231833696207 0.203503006033967 0.852959543285214 -0.507778912866275 "PIK3R1 MUT" "Sunitinib_IC_50" 0.259384136949957 0.723189643810247 1.19797153608248 0.768912641045069 0.973590705992338 -0.229652130571421 0.196741770890837 0.851001889249827 1.18730932947147 "KRAS MUT" "Vorinostat_IC_50" 0.0452169636985336 0.38006499344648 0.306498492963827 0.769124065201571 0.973590705992338 -0.0365055081848513 0.263285840904114 0.877052916121269 0.182109572954257 "KIT MUT" "Tipifarnib_IC_50" 0.546810310956799 0.863174968291385 -0.605794097902101 0.769213752023343 0.973590705992338 0.196681084062429 0.686591069396326 0.961100601384891 -0.400052863517749 "MS-HL MUT" "BMS.536924_IC_50" 0.365974512429316 0.788563052166059 0.379567792217899 0.769308453462136 0.973590705992338 0.0916440588163962 0.386269457906164 0.91566150942174 0.391680151000709 "CDKN2a(p14) MUT" "Rapamycin_IC_50" 0.0721420349571524 0.474889173046706 -0.669606913602944 0.769348827019327 0.973590705992338 -0.10120025795019 0.719808239710498 0.965068988053885 -0.154267282213327 "IDH1 MUT" "Bleomycin_IC_50" 0.490148058912102 0.84263880174142 -1.61187565217392 0.769351677463369 0.973590705992338 -0.556343189887688 0.724995670222489 0.965402608571648 -0.796638200217027 "AKT2 MUT" "Vorinostat_IC_50" 0.259979193644803 0.723189643810247 0.640416182178225 0.769518851937318 0.973590705992338 0.127127362138143 0.298445684390965 0.894167310052 0.544501219972139 "NRAS MUT" "XMD8.85_IC_50" 0.792569863528528 0.948304071878264 -0.108420109890112 0.769635900189693 0.973590705992338 -0.106760211386858 0.734671788320804 0.96672489654949 0.15485928873567 "MLH1 MUT" "BMS.708163_IC_50" 0.567000735687149 0.872389778906173 -0.285537335585582 0.769656836255004 0.973590705992338 -0.147627703702779 0.616542435071246 0.950247055931602 -0.251055538519707 "MDM2 MUT" "Sorafenib_IC_50" 0.837928151659906 0.959212868273494 0.170687263698632 0.76977388551937 0.973590705992338 0.232066037060047 0.713612469130929 0.962630898212352 0.316043201210399 "KDM6A MUT" "CCT007093_IC_50" 0.771259959638609 0.939969768292917 -0.0827900193627888 0.769795511482739 0.973590705992338 -0.0836928126112492 0.56278901995179 0.949294892873838 -0.167209866265444 "TET2 MUT" "Embelin_IC_50" 0.893756535284849 0.976022725555062 0.110677102206735 0.77020398674209 0.973807157771397 -0.195943115143364 0.936421561568101 0.99481859098592 -0.0801316516053487 "PDGFRA MUT" "ZM.447439_IC_50" 0.650996769082252 0.89914499319121 -0.324891935166993 0.770283430135204 0.973807157771397 -0.166743604864205 0.550948149702767 0.947060194029534 -0.410871872097449 "CTNNB1 MUT" "RDEA119_IC_50" 0.712367320570596 0.919646314953749 -0.262870066348969 0.770295606727177 0.973807157771397 0.188520136222814 0.605922723890346 0.949657634568742 0.349038771969238 "EZH2 MUT" "KU.55933_IC_50" 0.660012876522036 0.902400992643984 -0.248123214285716 0.770418611402204 0.97382403755522 -0.145726122337809 0.53152326267523 0.94320946427311 -0.346969030900418 "FBXW7 MUT" "CCT007093_IC_50" 0.864378375605431 0.967489995749939 0.0469253276539968 0.770668831142263 0.973838539376762 -0.0803196489053373 0.455421399580439 0.925809648901546 -0.217223682050615 "VHL MUT" "JNK.9L_IC_50" 0.410681888779808 0.812480994891775 -0.402164973867588 0.770674245374875 0.973838539376762 -0.11208022192979 0.679815532874183 0.961100601384891 -0.216926135461197 "MYCL1 MUT" "S.Trityl.L.cysteine_IC_50" 0.824132751490833 0.957177484110155 -0.19126741264368 0.770828785175211 0.973838539376762 -0.138607193598764 0.485448425464413 0.933639405738697 -0.636677266670805 "SMAD4 MUT" "Thapsigargin_IC_50" 0.341814660412366 0.778773897785973 -0.521020806003025 0.770868700801558 0.973838539376762 -0.125600107748106 0.23228682749111 0.869962136993019 -0.683033938220001 "PIK3R1 MUT" "WZ.1.84_IC_50" 0.423649731415694 0.818030912158927 0.604334501718216 0.771175210969863 0.974087192237712 -0.182496282536343 0.397360691233014 0.916480913435499 0.601930531527269 "CDK4 MUT" "Parthenolide_IC_50" 0.694949111897858 0.913615900582776 -0.443536936026933 0.771436128941436 0.974278194130958 0.307761036707017 0.884060109263523 0.988301482344111 -0.170471575358048 "EGFR MUT" "Camptothecin_IC_50" 0.247685027612423 0.714668105985286 0.553467693675888 0.77164381796661 0.974401926256429 0.0884636052069159 0.861949514842308 0.985636848898056 0.0770287077564888 "KDM5C MUT" "Doxorubicin_IC_50" 0.482031476050901 0.838752471082649 -0.687716593368249 0.772054356838782 0.974716455176227 -0.176628331192946 0.563836237973726 0.949294892873838 -0.535605635771463 "KIT MUT" "A.443654_IC_50" 0.331568918423779 0.772603259108552 -1.39601444217687 0.772112404252309 0.974716455176227 -0.280735123952204 0.489540641873085 0.933639405738697 -1.02372629514921 "FLCN MUT" "PF.02341066_IC_50" 0.354424709953618 0.785252181551816 0.873372191919187 0.772286070391516 0.974724207607591 0.251737159270018 0.922156503620807 0.993931766508607 0.159610468222474 "BRCA2 MUT" "Parthenolide_IC_50" 0.356556910744937 0.786601117838604 1.04215077441076 0.772338053027206 0.974724207607591 0.304929107982851 0.371391494551255 0.913948248824328 1.05289019361262 "MSH2 MUT" "GW843682X_IC_50" 0.672364446966776 0.907763880353539 0.42530317869416 0.772474935759721 0.974758440534538 0.150934440199145 0.750259447694658 0.968780465757047 0.338700066657418 "BRCA2 MUT" "OSI.906_IC_50" 0.540175616807017 0.861583989379152 0.512308203152369 0.772585903426042 0.974759967087183 0.229845148016188 0.696155517179719 0.961100601384891 0.331312851930336 "EGFR MUT" "AZD7762_IC_50" 0.182194899035233 0.658636992153339 0.518872773447344 0.772927192680099 0.974809300144136 0.0879906718295773 0.661654321983713 0.958689538788368 0.162619543625017 "KDR MUT" "SL.0101.1_IC_50" 0.6434972618037 0.89631417535738 0.326096410256411 0.772975160281969 0.974809300144136 -0.177255153462842 0.831498059939768 0.981482581683432 0.145561630798614 "PTEN MUT" "Vinorelbine_IC_50" 0.561130152805215 0.870276331255523 -0.136781756530827 0.773060235751567 0.974809300144136 -0.0507204487695556 0.474925371063137 0.929844139269115 -0.179894073902581 "SETD2 MUT" "KIN001.135_IC_50" 0.664157297905257 0.903589924015879 -0.239363468013465 0.773064058204611 0.974809300144136 0.157260814846456 0.970295823620972 0.997173634484198 0.0194661731872089 "EZH2 MUT" "Nutlin.3a_IC_50" 0.651776852018605 0.899243470992269 -0.422647458823531 0.773249752701773 0.974905033183481 -0.245538490616718 0.835422738180918 0.981626636221501 -0.187890357986474 "STK11 MUT" "RO.3306_IC_50" 0.706524770257748 0.916675892572543 0.120593281596452 0.773479159176647 0.975055842817289 0.0881422335666396 0.61250965609539 0.949930222127033 0.174203899916979 "EGFR MUT" "Parthenolide_IC_50" 0.352719659776212 0.785062892590933 0.476247889273355 0.773756131701137 0.975170161001741 0.135795380669093 0.20342223299181 0.852959543285214 0.676232892763368 "MYCN MUT" "MS.275_IC_50" 0.60339617319193 0.881230293392128 0.263883536363638 0.773826488710888 0.975170161001741 -0.124185099566477 0.859436360762963 0.985479880500142 0.110680135646726 "PIK3R1 MUT" "Vorinostat_IC_50" 0.192917971829021 0.668215486666746 0.586821764442239 0.773899256248201 0.975170161001741 0.098842814168193 0.35956742458746 0.91161229252998 0.375190296496338 "ERBB2 MUT" "AZD.0530_IC_50" 0.824358168872644 0.957177484110155 0.225890833898306 0.774564112354271 0.975504141629365 0.255887847063083 0.685352388563464 0.961100601384891 0.402828423577579 "HRAS MUT" "Obatoclax.Mesylate_IC_50" 0.653775372630342 0.900904870244158 0.463967013986009 0.774566352636403 0.975504141629365 -0.218685148775773 0.377223124523752 0.914419412871569 0.876695424096482 "BRAF MUT" "JNK.9L_IC_50" 0.923776619500439 0.98643792569589 -0.0186215365533895 0.774581253245785 0.975504141629365 0.0460864030038447 0.579710465481832 0.949294892873838 -0.127883928395539 "KRAS MUT" "ATRA_IC_50" 0.0355758339294307 0.347105523744792 0.426563639534886 0.774603671520131 0.975504141629365 0.048705547194046 0.777543662400411 0.972337708041191 -0.0585140003433098 "FLT3 MUT" "Etoposide_IC_50" 0.17700531719402 0.656360844258911 -1.65769992041523 0.7747464164346 0.975545572714545 0.232319557572901 0.495467673100556 0.933639405738697 -0.798589812163049 "MDM2 MUT" "NU.7441_IC_50" 0.411606232192585 0.812480994891775 0.375062673346692 0.775005365727326 0.975609075046487 -0.114596689233004 0.450232527324031 0.925809648901546 0.330288255079663 "BRCA1 MUT" "AZD6244_IC_50" 0.788874985661836 0.946884544892927 0.301185280538299 0.775016554943471 0.975609075046487 0.294080986923308 0.974630403582354 0.99742775226181 -0.031838260751969 "FBXW7 MUT" "Cyclopamine_IC_50" 0.182405294911524 0.658780571008235 -0.633273661971834 0.775345466334262 0.975876634029225 -0.126638924210282 0.449050418067741 0.925809648901546 -0.373521848207285 "CDH1 MUT" "Docetaxel_IC_50" 0.407626708927962 0.809352267869285 0.533112203124996 0.77595957020108 0.975876634029225 0.139223376277746 0.679214087300768 0.961100601384891 0.275843287516711 "AKT2 MUT" "BAY.61.3606_IC_50" 0.404709262627976 0.807904911469051 -0.605540564411032 0.775993695458237 0.975876634029225 0.143566358981777 0.0888611979168163 0.758159640835928 -1.17385237770106 "MSH6 MUT" "ABT.888_IC_50" 0.123644413305386 0.583699714338599 -0.618684263186806 0.776010571933924 0.975876634029225 -0.0965031559991942 0.173209396582734 0.844239622796781 -0.509348235764419 "VHL MUT" "Sunitinib_IC_50" 0.430022286917317 0.820918238409269 0.838682463917532 0.776082169284009 0.975876634029225 0.22827748974243 0.48049025018 0.930304161706959 0.76683542326574 "KDM6A MUT" "PD.173074_IC_50" 0.343964517435324 0.780249349533262 -0.326971433691758 0.776091395098714 0.975876634029225 0.0840760102763665 0.400984246737332 0.916589616820582 -0.27532912496064 "BCR_ABL MUT" "PD.173074_IC_50" 0.00193538928959706 0.0658551428387413 -2.23113538235295 0.776167800656296 0.975876634029225 0.216313940077636 0.135524705998853 0.828937189282754 -1.02345833804351 "FAM123B MUT" "Methotrexate_IC_50" 0.378213772196829 0.795952477739693 1.13010007028111 0.776207947011001 0.975876634029225 -0.277296975291721 0.525347051379082 0.940554660491705 0.650050105647443 "FGFR2 MUT" "Erlotinib_IC_50" 0.360892636888515 0.786783098836476 0.911384355231148 0.776287274161548 0.975876634029225 0.262616600164688 0.88550574839982 0.988301482344111 0.171325000685378 "MSH6 MUT" "KIN001.135_IC_50" 0.556270725080368 0.867684663540343 0.230116101694914 0.776327938229532 0.975876634029225 0.108680296955191 0.773568944323736 0.971308609435756 0.104915043637301 "PIK3R1 MUT" "Vinblastine_IC_50" 0.200149845296321 0.674012093366938 0.814748463051811 0.776557306985062 0.975936448648089 0.130500878164107 0.343831692072986 0.907180409180092 0.56319176781424 "IDH1 MUT" "Docetaxel_IC_50" 0.454287118519679 0.828966839128293 -0.957948942084943 0.776595302623133 0.975936448648089 0.27143946671614 0.661480607269178 0.958689538788368 -0.543996549068382 "MYCL1 MUT" "LFM.A13_IC_50" 0.791079545284494 0.94790644179192 -0.0934605467372139 0.777110667876227 0.976059320897799 -0.093969235858398 0.422590200138982 0.922428741067589 -0.307559416051131 "MYCL1 MUT" "AUY922_IC_50" 0.882397735400546 0.973927829424842 0.0893573597883608 0.777437055009032 0.976059320897799 0.11459415646589 0.146731658143658 0.831473272394224 -0.913782760350977 "CCND1 MUT" "Sunitinib_IC_50" 0.117215420986353 0.572601844763368 1.08615118661971 0.777460412672802 0.976059320897799 0.14759619297712 0.591615821861912 0.949294892873838 0.378674394912896 "MET MUT" "NSC.87877_IC_50" 0.430961058918573 0.820918238409269 -0.268297771055562 0.777583025450537 0.976059320897799 -0.094942568428309 0.647885482446715 0.957449344088104 -0.157732435924028 "KDR MUT" "Bicalutamide_IC_50" 0.936670815679401 0.988375382416448 0.0285310917537741 0.777731321869726 0.976059320897799 0.0964506104964235 0.665693543470092 0.959206771190239 0.146892264852427 "CDK6 MUT" "AZD7762_IC_50" 0.165804717453908 0.6441433489537 0.832035419347917 0.777983628468331 0.976059320897799 0.132284018049155 0.264670777452361 0.877052916121269 0.608886104307263 "EGFR MUT" "Bryostatin.1_IC_50" 0.65973964605575 0.902400992643984 -0.118101400643541 0.778052047163665 0.976059320897799 -0.0716245061182063 0.844451922435021 0.983349844199673 -0.0528846073808363 "FLCN MUT" "Bortezomib_IC_50" 0.632851191281003 0.89399270048764 0.624084772468714 0.778115352887285 0.976059320897799 0.298871927461368 0.960343211859624 0.996507965993903 0.109090032924261 "PIK3R1 MUT" "BI.D1870_IC_50" 0.334432570663867 0.773264085106582 0.553166093930633 0.778226410279863 0.976059320897799 0.139316821598062 0.712245629626076 0.962630898212352 0.199792497573053 "ERBB2 MUT" "PD.0332991_IC_50" 0.00793306133059491 0.156679237330372 1.28722584392992 0.778410687660289 0.976059320897799 0.113610188544665 0.6414104230907 0.955103296458244 0.226581332204407 "FGFR2 MUT" "Thapsigargin_IC_50" 0.0121534903925721 0.197683421568559 3.61074595287962 0.778487574826657 0.976059320897799 -0.314730038251078 0.10274332076643 0.779217277307144 2.63571299129527 "BCR_ABL MUT" "CGP.082996_IC_50" 0.252868317267409 0.717874556377469 -0.940502773972616 0.778509003936891 0.976059320897799 -0.246869856444502 0.563924738185438 0.949294892873838 -0.478157441522909 "JAK2 MUT" "Roscovitine_IC_50" 0.931112656809554 0.986689293492114 0.0839056516724337 0.778581519490953 0.976059320897799 0.238842457291454 0.632837576970927 0.952523560833852 0.572233556629197 "FGFR2 MUT" "JNK.Inhibitor.VIII_IC_50" 0.724936654501042 0.924731250116011 0.284794076190479 0.778633785395122 0.976059320897799 0.219149553511023 0.474835659179034 0.929844139269115 -0.82171603827348 "FGFR3 MUT" "AZD6482_IC_50" 0.585207900526241 0.876506729771444 -0.621149062176156 0.778920440066062 0.976059320897799 0.269559719747971 0.671419383478453 0.960241983012847 -0.470102509929701 "MAP2K4 MUT" "Embelin_IC_50" 0.387154822354107 0.799423849645855 -0.347202990998358 0.779159084811483 0.976059320897799 -0.0899255362157844 0.284816626892347 0.8879937007725 -0.466908268774405 "MET MUT" "AZD7762_IC_50" 0.200395157344325 0.674012093366938 0.667794163915854 0.779286214176786 0.976059320897799 -0.114663628583151 0.681772614421212 0.961100601384891 0.194584617284786 "CDKN2C MUT" "GDC0941_IC_50" 0.961426083068674 0.993899806776065 0.0313139999999996 0.779315273023834 0.976059320897799 0.146477283844716 0.53264763104494 0.943443271455699 0.429986019556384 "ALK MUT" "EHT.1864_IC_50" 0.584713874815625 0.876506729771444 -0.489800446428571 0.779587029708176 0.976059320897799 -0.250207508687844 0.886326491366584 0.988301482344111 0.126372100338736 "CDKN2a(p14) MUT" "FTI.277_IC_50" 0.00665203686339962 0.14099460473473 -0.257562375463395 0.779611673402886 0.976059320897799 -0.0254327907335681 0.665851810306373 0.959206771190239 0.0436301581327659 "MSH6 MUT" "NVP.BEZ235_IC_50" 0.353387361121248 0.785062892590933 -0.587913307281235 0.779656545009686 0.976059320897799 -0.128188884102166 0.355321902725604 0.91161229252998 -0.552330511075312 "CTNNB1 MUT" "AZD.2281_IC_50" 0.984475072195236 0.996723172778267 -0.00888178994352369 0.779915341265327 0.976059320897799 -0.0964671791030165 0.236359646455481 0.871856821645725 -0.498997539725384 "CDK6 MUT" "CGP.60474_IC_50" 0.47934832207637 0.836304203722611 0.763171754266212 0.780197446260528 0.976059320897799 0.223259302375393 0.194662568847427 0.851001889249827 1.66531545421501 "IDH1 MUT" "Bicalutamide_IC_50" 0.870533030318027 0.969692600253955 0.0716143130434787 0.780232518301285 0.976059320897799 0.116057937700505 0.855990416376292 0.984631915507353 0.0751801263852353 "CDK6 MUT" "JNK.9L_IC_50" 0.597779941605012 0.879232253518807 0.243413188481675 0.780240294899683 0.976059320897799 0.100662330552476 0.379153307106984 0.915134825237766 0.425801479852976 "MYCN MUT" "Lapatinib_IC_50" 0.27671614683957 0.735108059249974 0.448445588235293 0.780290645653126 0.976059320897799 -0.100998591355524 0.149491063897868 0.831473272394224 -0.617045703251871 "FGFR3 MUT" "XMD8.85_IC_50" 0.223831817488319 0.696139064632428 -1.56939339041096 0.780334902819787 0.976059320897799 -0.309866207551849 0.393920105089987 0.915926348152589 -1.08441494700679 "NRAS MUT" "BAY.61.3606_IC_50" 0.226734488659087 0.699276507734018 -0.370060153627056 0.780649822983675 0.976059320897799 -0.0610225664728427 0.957632907749475 0.99641548698706 0.0174687091617204 "FLCN MUT" "SB590885_IC_50" 0.524468633321073 0.854725328793752 0.581443668699188 0.780727314010133 0.976059320897799 0.212566435536015 0.681746931997231 0.961100601384891 0.461888113169092 "PIK3R1 MUT" "MK.2206_IC_50" 0.971210232905434 0.995220468612913 0.0229715151356993 0.780805632808394 0.976059320897799 -0.141362017611461 0.84345236195981 0.983031552042661 0.122109518149685 "TET2 MUT" "GW843682X_IC_50" 0.430433786054536 0.820918238409269 -1.11520348639457 0.780825042979799 0.976059320897799 -0.205110822463749 0.29554340553937 0.894167310052 -1.86906574962029 "EGFR MUT" "OSI.906_IC_50" 0.56387835306188 0.871754997395969 0.250275488306388 0.780859826133121 0.976059320897799 0.113667377669099 0.752902036825128 0.968780465757047 0.144230926097661 "MLH1 MUT" "GSK269962A_IC_50" 0.564394638318203 0.871766547058339 0.477407015570937 0.780961327171823 0.976059320897799 -0.217612860424602 0.672776995227726 0.960256725054738 0.353033780503514 "MYCN MUT" "PF.02341066_IC_50" 0.286817844838741 0.741767408273984 0.391649148489501 0.780990086894038 0.976059320897799 -0.0986571948228071 0.352502235038539 0.91110953125066 -0.402340376167847 "RB1 MUT" "CCT018159_IC_50" 0.754365359501432 0.933900277236682 -0.0751130269704116 0.781119025023052 0.976059320897799 -0.0633777930738134 0.429975200379434 0.922428741067589 -0.207846220689685 "PIK3CA MUT" "AZD7762_IC_50" 0.126379884176428 0.587206821914858 0.402091289915969 0.781190556885942 0.976059320897799 0.0578515460678676 0.432974618880168 0.922569292988365 0.206852239856198 "BRCA2 MUT" "X681640_IC_50" 0.407507427861899 0.809352267869285 0.677957855397148 0.781191849189584 0.976059320897799 0.195198971773803 0.683329875412149 0.961100601384891 0.314831914214883 "BRCA2 MUT" "Embelin_IC_50" 0.626468571595286 0.89123540333742 0.285924880326913 0.781253351672307 0.976059320897799 0.131032755118877 0.839203142069139 0.98178039101519 0.119083947516937 "NRAS MUT" "MK.2206_IC_50" 0.763986790909842 0.936244886169491 -0.0980374111263725 0.781262641013624 0.976059320897799 -0.0752899139874784 0.655638806242327 0.958313128388245 -0.163271821816603 "ALK MUT" "Gefitinib_IC_50" 0.808448364334859 0.952641225877339 -0.278858527514231 0.781380414119168 0.976059320897799 -0.289089988928691 0.561926065995437 0.949294892873838 -0.604663939556723 "CDKN2a(p14) MUT" "QS11_IC_50" 0.180240918801214 0.658614416960816 -0.2279221450581 0.781390354282682 0.976059320897799 0.036369433813977 0.437132504793564 0.922569292988365 -0.144020607409365 "PIK3R1 MUT" "AZD.2281_IC_50" 0.500766449771473 0.846139048786236 0.359198814741041 0.781403408036078 0.976059320897799 -0.111741846705175 0.716653569798017 0.963749296392518 0.169637320706352 "CCND1 MUT" "PD.0325901_IC_50" 0.871760097952921 0.970309741812243 0.0743902692946065 0.78141895862891 0.976059320897799 0.121093051359351 0.40529705716002 0.917928412078554 0.362617483101112 "MLL_AFF1 MUT" "Shikonin_IC_50" 0.366226214191764 0.788563052166059 -1.30878440689655 0.781562773804782 0.976101672642423 -0.344095066780341 0.802295583148999 0.976365695720597 -0.356194014752604 "CDK6 MUT" "AZD8055_IC_50" 0.463944724932053 0.829490249358073 0.349579420348057 0.782042050901613 0.976492403066607 0.102669362514612 0.720760460878239 0.965402608571648 0.164870664053441 "KIT MUT" "Docetaxel_IC_50" 0.279564204292023 0.737882141891724 -0.980431302325581 0.782318868963387 0.976492403066607 0.189073448803532 0.464250930238714 0.929276781658587 -0.64484744022437 "EWS_FLI1 MUT" "BI.D1870_IC_50" 0.111935267778499 0.563419220713034 -0.692115740740749 0.782574950116636 0.976492403066607 -0.11145179730067 0.902998672239588 0.988746233284632 0.0584418353278121 "CDH1 MUT" "Cisplatin_IC_50" 0.370236983043212 0.790171942552447 0.529127011516306 0.782581847612674 0.976492403066607 0.142971594337277 0.85763695935028 0.984898622336936 -0.109138732321084 "ALK MUT" "MK.2206_IC_50" 0.449926989811205 0.827950185889909 -0.781006552341587 0.78259614326226 0.976492403066607 -0.227960709461232 0.752467967484644 0.968780465757047 -0.391260267789926 "CDK6 MUT" "Sunitinib_IC_50" 0.315227747823254 0.760537253034044 1.37277546188851 0.782643470595209 0.976492403066607 0.277223209262039 0.107982855576707 0.792785095696032 2.34602313469932 "KDM6A MUT" "Nutlin.3a_IC_50" 0.754423255973479 0.933900277236682 -0.140043164426523 0.78265518450036 0.976492403066607 0.114069836635851 0.940059023809557 0.995120990231635 0.0336126557759586 "MET MUT" "MS.275_IC_50" 0.396082659674191 0.80402516584377 1.32006582593858 0.782882463966636 0.976492403066607 0.35342690550705 0.404602317470198 0.917353377955789 1.34838667201929 "CDH1 MUT" "SB.216763_IC_50" 0.469761516160627 0.832012966658205 0.40023950224972 0.783070963683455 0.976492403066607 0.148409738086671 0.327761229053653 0.902810042912437 0.565468641983624 "MS-HL MUT" "AZD6482_IC_50" 0.16539054948244 0.64339386611283 -0.347302406138394 0.78352210997991 0.976492403066607 -0.0584683063587763 0.00610123786793169 0.368388397903175 -0.743831146960147 "TET2 MUT" "SB590885_IC_50" 0.334113063581216 0.773264085106582 -1.01754992900606 0.783578961095116 0.976492403066607 -0.245277537160292 0.881895664555494 0.988301482344111 0.168445186392119 "AKT2 MUT" "AG.014699_IC_50" 0.869894978842545 0.969505966359972 0.0968056960784325 0.783639531613873 0.976492403066607 0.14282839574954 0.907315886374485 0.989302932706175 0.0643395743425432 "KRAS MUT" "BIBW2992_IC_50" 0.613482646226338 0.885333016109215 0.112871428736415 0.783738190749055 0.976492403066607 -0.0622208563018807 0.0940838393368928 0.768683143653123 0.400983407634055 "NF1 MUT" "Vinorelbine_IC_50" 0.0655447615454303 0.457742485196035 0.809267661525964 0.783774172233805 0.976492403066607 0.089214265440503 0.479345765867546 0.930304161706959 0.330913860952524 "MAP2K4 MUT" "Axitinib_IC_50" 0.455572461611658 0.828966839128293 0.387376647969056 0.784121773214034 0.976492403066607 0.120109481448904 0.221676873766121 0.865076203633533 -0.616545076658622 "BRCA2 MUT" "AMG.706_IC_50" 0.742797540328366 0.929570057037101 0.211219235294118 0.784264370413307 0.976492403066607 -0.162943851520299 0.736346372338258 0.96672489654949 -0.200574448966178 "ALK MUT" "GNF.2_IC_50" 0.461005724691741 0.828966839128293 0.465073380136987 0.784600720864031 0.976492403066607 0.166380838562022 0.85151804890037 0.984550422117456 0.140416580373626 "IDH1 MUT" "AZD8055_IC_50" 0.584492453044939 0.876506729771444 -0.549919885148521 0.78472083238207 0.976492403066607 -0.212635491816477 0.594220062688862 0.949294892873838 -0.521694028388724 "SMARCB1 MUT" "GSK.650394_IC_50" 0.805069070846364 0.952510646223648 -0.363801777391303 0.784739812243085 0.976492403066607 0.259441003206695 0.955695719972828 0.996100446818628 0.0825566857922259 "MYC MUT" "SB.216763_IC_50" 0.673950227425467 0.908418658675584 0.100796415789474 0.784896909549848 0.976492403066607 0.0635094431106923 0.650240025564912 0.957867556929346 0.109845229394568 "MLH1 MUT" "SL.0101.1_IC_50" 0.446908480124551 0.825993088400314 -0.281993022017042 0.784926675876123 0.976492403066607 0.0893927478762061 0.726910072245509 0.965402608571648 -0.125675870916285 "MDM2 MUT" "AZD6482_IC_50" 0.470388100177932 0.832012966658205 0.452661085664336 0.78497350794372 0.976492403066607 0.144270944611932 0.20545706261985 0.853446327418758 0.772481750793803 "CCND3 MUT" "GSK.650394_IC_50" 0.924828674047364 0.98643792569589 -0.0985237731239115 0.785054148681187 0.976492403066607 -0.184323980046511 0.975611874408744 0.99742775226181 -0.031803911797592 "FLCN MUT" "SB.216763_IC_50" 0.965208853130002 0.994434372972651 -0.0318624070450104 0.78507335727511 0.976492403066607 -0.192276811114623 0.211645338381879 0.855272470862467 1.24041160039837 "CDKN2C MUT" "NSC.87877_IC_50" 0.431395723303238 0.820918238409269 0.28088202797203 0.785093855021226 0.976492403066607 0.0960988293257125 0.645453512478943 0.956971941901975 0.198917472767901 "JAK2 MUT" "JW.7.52.1_IC_50" 0.892668017083375 0.975972789421281 0.210630850340139 0.785148626094002 0.976492403066607 0.256629287217601 0.235032801209387 0.869962136993019 2.32037471593396 "MAP2K4 MUT" "AS601245_IC_50" 0.625191656532241 0.890724841246629 -0.246833006819418 0.78520515008603 0.976492403066607 0.109986221350166 0.208460976436716 0.853446327418758 -0.690303683399867 "STK11 MUT" "Vinblastine_IC_50" 0.580715597493023 0.875665027612815 0.21486341187018 0.785315337536666 0.976492403066607 0.0766319177082419 0.520162337999422 0.939635632721979 0.250860948938105 "FBXW7 MUT" "BAY.61.3606_IC_50" 0.214664731572713 0.688117861819268 -0.515297218837014 0.785540305588168 0.976492403066607 -0.0789458901506289 0.885013299582332 0.988301482344111 -0.0587052709572634 "KDM6A MUT" "Vorinostat_IC_50" 0.217603903719568 0.689975030887399 -0.396135823380566 0.785642928907361 0.976492403066607 -0.0672844219866092 0.0397255004171149 0.650264437987822 -0.622418943234251 "EGFR MUT" "AZD8055_IC_50" 0.967109573549608 0.994434372972651 0.0127596423617619 0.785673512646929 0.976492403066607 0.0656849769811967 0.58818411896011 0.949294892873838 -0.169965080548705 "NOTCH1 MUT" "Rapamycin_IC_50" 0.122370405691639 0.580982694522287 -1.42886587323058 0.785697769195248 0.976492403066607 -0.225880471140089 0.231945255116635 0.869962136993019 -1.29311239371817 "NRAS MUT" "Docetaxel_IC_50" 0.731868149603614 0.928176068595523 -0.10434499759773 0.785822253697857 0.976492403066607 0.064719094866236 0.357944511247748 0.91161229252998 -0.306578685405491 "SMAD4 MUT" "QS11_IC_50" 0.655028555842979 0.901074441039429 -0.166946219670276 0.785978591799426 0.976492403066607 -0.0769000098845693 0.27924759896956 0.885713545160236 -0.423576642080083 "MSH6 MUT" "BX.795_IC_50" 0.726490623952477 0.92547791524492 0.280526593495941 0.78606158534339 0.976492403066607 0.167920874007608 0.90075559590732 0.988704788932507 0.0877777816052466 "MLLT3 MUT" "AG.014699_IC_50" 0.723898137047232 0.924072376079985 0.129317247685187 0.786184394273346 0.976492403066607 0.0872842448615215 0.751320555594824 0.968780465757047 0.110058408099156 "NRAS MUT" "DMOG_IC_50" 0.672485351281505 0.907767897812007 -0.121202804232804 0.786211116397797 0.976492403066607 -0.0722042865686957 0.190453055006271 0.851001889249827 0.404595414372899 "PIK3CA MUT" "Bryostatin.1_IC_50" 0.997854449390453 0.999204573800497 -0.000484551873096727 0.786439277764938 0.976492403066607 0.0464868539614192 0.673101786897854 0.960256725054738 0.0797122396934928 "NF1 MUT" "GW.441756_IC_50" 0.94375296177581 0.990147156460271 0.0186898208714362 0.786757819412324 0.976492403066607 0.070337421034364 0.736015611539324 0.96672489654949 0.0940637569419552 "FAM123B MUT" "IPA.3_IC_50" 0.81977723570477 0.955629000670661 0.211234555944059 0.786796761593055 0.976492403066607 -0.21046680614324 0.685101119324389 0.961100601384891 -0.354235197592728 "MSH6 MUT" "PF.4708671_IC_50" 0.977236160624728 0.996276778834563 0.016839076576577 0.786818299528741 0.976492403066607 0.157439441875277 0.769644618137271 0.969901216545994 0.17503443993769 "PIK3R1 MUT" "ZM.447439_IC_50" 0.474499081328133 0.834460661638643 0.407202270750983 0.786982010648347 0.976492403066607 -0.12222459626555 0.76098488896529 0.969901216545994 0.163028312832636 "EP300 MUT" "BIBW2992_IC_50" 0.734757407609976 0.928747585679504 -0.372026942332061 0.787147857328573 0.976492403066607 -0.285427180711394 0.623221210809876 0.950496524771391 -0.495403722891767 "FGFR2 MUT" "AZD.0530_IC_50" 0.236520908388422 0.709402967712791 1.38722923761262 0.78716575236547 0.976492403066607 0.279815604374831 0.950672783224244 0.995668765770473 0.0833520074408828 "KDR MUT" "Embelin_IC_50" 0.593384338473027 0.878261059495448 -0.442432015098717 0.78726314317656 0.976492403066607 0.178616166130828 0.951682318542718 0.995669074626174 -0.0501900939291097 "MLLT3 MUT" "Sunitinib_IC_50" 0.965911652519194 0.994434372972651 -0.0324124860139854 0.787288569808728 0.976492403066607 -0.149570666237352 0.575414332527755 0.949294892873838 0.39163571029603 "KDR MUT" "BMS.708163_IC_50" 0.646745248137626 0.897186614618066 0.322201170022372 0.787327822194911 0.976492403066607 0.191828187928436 0.99711186681279 0.999545005862799 0.00260219154273038 "APC MUT" "Bosutinib_IC_50" 0.0233399081389291 0.277857539117734 0.752731433467749 0.787472068518508 0.976492403066607 -0.0775947522661349 0.52492420801524 0.940554660491705 0.240575273279909 "IDH1 MUT" "LFM.A13_IC_50" 0.792714952504298 0.948304071878264 0.205862782608697 0.787644858305981 0.976492403066607 0.197985035375163 0.546097090417514 0.946853280734584 0.473575708703268 "CDH1 MUT" "Bleomycin_IC_50" 0.156216197171613 0.63139838220137 1.56981845266043 0.787878215853505 0.976492403066607 0.246402672186218 0.429013400998838 0.922428741067589 0.903885051100565 "ALK MUT" "AZD7762_IC_50" 0.241514592438306 0.711340033600749 -1.48210002666668 0.7879017178823 0.976492403066607 0.266908988698113 0.194407756293322 0.851001889249827 -1.50335408621718 "APC MUT" "IPA.3_IC_50" 0.391127789195169 0.80203322462302 0.326737827366178 0.787986791697153 0.976492403066607 0.0898104748993923 0.298478071595654 0.894167310052 -0.448099407846547 "EP300 MUT" "AICAR_IC_50" 0.562131048167054 0.870798157818177 -0.575552906976745 0.787994946847395 0.976492403066607 -0.24009453732291 0.453902291785073 0.925809648901546 -0.709800111400662 "MLL_AFF1 MUT" "Camptothecin_IC_50" 0.0821641493964323 0.497724838837149 -2.76328375142313 0.788008041540513 0.976492403066607 -0.274985637214259 0.882056585275651 0.988301482344111 -0.210876375187337 "CTNNB1 MUT" "GDC0941_IC_50" 0.794451897579478 0.948646027682356 -0.144302080829213 0.788065910735062 0.976492403066607 -0.119929563570966 0.167076680078899 0.84067330207935 -0.84206633932667 "MLH1 MUT" "JNK.Inhibitor.VIII_IC_50" 0.450545224062033 0.828077050034054 -0.262599763918251 0.788551288709246 0.976492403066607 -0.0903207515344456 0.696294727893807 0.961100601384891 -0.13820455932679 "VHL MUT" "XMD8.85_IC_50" 0.944221396764125 0.990147156460271 0.0641302758620703 0.788561352492716 0.976492403066607 0.215991001725394 0.599276213945604 0.949657634568742 -0.49605858805717 "SMARCA4 MUT" "Gefitinib_IC_50" 0.349541066303416 0.784966682190403 0.484733971098267 0.788785947626274 0.976492403066607 0.124375758300694 0.919568095128972 0.993794649720217 -0.0538006926339865 "CDKN2a(p14) MUT" "GW843682X_IC_50" 0.0763165394694572 0.483683312058227 -0.533413797164945 0.78884105466512 0.976492403066607 0.044693215144914 0.323365317386581 0.900918773778407 -0.350966051255887 "GNAS MUT" "ABT.888_IC_50" 0.318961007869485 0.761311064402907 0.400727742307689 0.788852937579597 0.976492403066607 0.0908137295808119 0.33391237753553 0.903569160603576 0.363831171858542 "CDK6 MUT" "Camptothecin_IC_50" 0.276337773119741 0.735108059249974 0.821953080555548 0.78889289209948 0.976492403066607 0.12778337833528 0.598872269247711 0.949657634568742 0.350210372747465 "MLH1 MUT" "PD.0332991_IC_50" 0.822487433708125 0.956993500507893 -0.141288375262054 0.789000616310605 0.976492403066607 0.136946362277398 0.408842553252488 0.920903133902018 0.492695942472529 "MSH6 MUT" "Temsirolimus_IC_50" 0.6772908483301 0.908720747099578 -0.36109922605364 0.789150276214775 0.976492403066607 0.177197063221084 0.742237782514866 0.96672489654949 -0.269426996987578 "PTEN MUT" "Axitinib_IC_50" 0.570349580775958 0.872389778906173 -0.125783247665197 0.78915843427263 0.976492403066607 0.0512615788212024 0.606888706132443 0.949657634568742 0.108831234370896 "SMARCA4 MUT" "Cisplatin_IC_50" 0.764200318617443 0.936377349564226 0.158796922928708 0.789212152141994 0.976492403066607 0.121786542370177 0.794449824566109 0.975460927965106 0.150710283346048 "KIT MUT" "BMS.708163_IC_50" 0.606258552752096 0.882942310100256 0.314162383408073 0.789263564917464 0.976492403066607 0.165011358704141 0.963742410325825 0.997051031866061 0.0282419232946377 "TSC1 MUT" "Vinblastine_IC_50" 0.379139077882601 0.796120156419408 -1.11271097153699 0.789453408865603 0.976492403066607 -0.24512077015496 0.578337588953301 0.949294892873838 -0.659158550436896 "SMARCA4 MUT" "BAY.61.3606_IC_50" 0.545187071652381 0.862633715268747 0.352016966591714 0.789491704563766 0.976492403066607 -0.107615628588004 0.657739734947009 0.958313128388245 0.272055367430852 "JAK2 MUT" "Etoposide_IC_50" 0.210278514098722 0.684261946425694 1.16600807254661 0.789533479302127 0.976492403066607 0.161434652751871 0.346517992140129 0.909317472748763 0.902856038481386 "RUNX1 MUT" "PD.0325901_IC_50" 0.828128632059491 0.958015830101332 0.282440958333329 0.789572339423635 0.976492403066607 0.325211658394487 0.736062826350171 0.96672489654949 0.380530791985838 "RUNX1 MUT" "CI.1040_IC_50" 0.938175470452355 0.98883650048509 0.0803070407903122 0.78971176741656 0.976528850797336 0.24609582866742 0.974598404861589 0.99742775226181 0.0288350983962116 "MET MUT" "Gefitinib_IC_50" 0.782026177430244 0.944314407151708 0.131177256931013 0.790219602361359 0.977013204902509 -0.113682209626169 0.976077385522853 0.99742775226181 -0.012797543091607 "BCR_ABL MUT" "Cisplatin_IC_50" 0.86809338455957 0.968656533267187 -0.138220051428572 0.790368310907616 0.977013204902509 -0.233508612382402 0.477512826555726 0.930304161706959 0.583119072877452 "NF2 MUT" "BMS.509744_IC_50" 0.198717319452485 0.674012093366938 -0.715184668989551 0.79070594920006 0.977013204902509 -0.111926031949759 0.514894108521351 0.939635632721979 -0.390530365470241 "JAK2 MUT" "GSK269962A_IC_50" 0.935677284736863 0.988214667968534 -0.1082668707483 0.790817276957966 0.977013204902509 -0.329401916493403 0.391225130010906 0.915926348152589 -1.41291647460642 "SMAD4 MUT" "VX.702_IC_50" 0.819380812378866 0.95535263157893 0.0676098960884736 0.791028052909665 0.977013204902509 -0.0658971562772569 0.331511508541152 0.902810042912437 -0.28381776839907 "GNAS MUT" "XMD8.85_IC_50" 0.576553767923724 0.873455460479685 0.511719931034487 0.791113922190586 0.977013204902509 0.209204434940169 0.607428837614398 0.949657634568742 0.4760932414137 "MAP2K4 MUT" "AZD6482_IC_50" 0.583217062954457 0.876506729771444 -0.302598909152357 0.79112911710299 0.977013204902509 -0.12328749087178 0.11771603857676 0.806041741403397 -0.925271449483947 "MLLT3 MUT" "BX.795_IC_50" 0.983562839939818 0.996723172778267 -0.00812310106840222 0.791136071237567 0.977013204902509 -0.0803462450049302 0.734318503235341 0.96672489654949 0.12445970453675 "MYC MUT" "AS601245_IC_50" 0.538045923598656 0.860998762866154 0.175805447696194 0.79116467167175 0.977013204902509 -0.0610014657791761 0.881221497400522 0.988301482344111 0.0445952836129932 "EP300 MUT" "XMD8.85_IC_50" 0.637101233940389 0.895268363706423 -0.609312226027405 0.791261428910923 0.977013204902509 -0.295028401786074 0.778741603668172 0.972337708041191 -0.356773157650744 "PTEN MUT" "Vinblastine_IC_50" 0.0411229036604718 0.366158293476655 -0.453871891629952 0.791443390351647 0.977013204902509 -0.04349789899054 0.220571976158506 0.864474168037968 -0.277948946814798 "TET2 MUT" "Pazopanib_IC_50" 0.752733328895673 0.933663817778872 -0.343598862369335 0.791485000447171 0.977013204902509 -0.248612471144243 0.704252632976291 0.962521950363564 -0.463347706557357 "MYCL1 MUT" "NVP.BEZ235_IC_50" 0.223701956686532 0.696139064632428 0.714125330177865 0.791533612124034 0.977013204902509 0.111867313071654 0.653030468818298 0.958313128388245 0.275809869108808 "MSH6 MUT" "MG.132_IC_50" 0.897647459813262 0.978280413621497 -0.153100506802722 0.791770271042038 0.977169507660414 -0.278035024830802 0.803936893217421 0.976660896667097 -0.272999935130608 "FBXW7 MUT" "Z.LLNle.CHO_IC_50" 0.573919718335583 0.872620551543038 -0.345485165698798 0.792087993630797 0.977395496651056 0.15130969196015 0.912955783059141 0.99082410867764 -0.0671796441621159 "GNAS MUT" "AKT.inhibitor.VIII_IC_50" 0.695603018791721 0.913718445479852 0.199846442307692 0.79224876574929 0.977395496651056 0.115295216362725 0.303774818119842 0.894622967627816 0.516882568273694 "PIK3R1 MUT" "BAY.61.3606_IC_50" 0.127905059911249 0.588664235316545 1.03510580667839 0.792283546941893 0.977395496651056 0.12451626450011 0.167754601450058 0.84067330207935 0.877132907390824 "CDK4 MUT" "QS11_IC_50" 0.842151043257385 0.960218694976099 0.139046046572936 0.792480061890916 0.977502143007393 0.135695563636168 0.967024474360323 0.997173634484198 -0.0299015846401149 "AKT2 MUT" "Sorafenib_IC_50" 0.890882586010079 0.975972789421281 -0.180088979661016 0.79278465313648 0.977742050340936 -0.325500854331899 0.939239316609675 0.994831655017307 -0.103601229764757 "FLT3 MUT" "KIN001.135_IC_50" 0.713068916124387 0.919658008147064 0.165818018018019 0.793224401620011 0.977826093138261 0.117161693178207 0.777473725238663 0.972337708041191 -0.120369623573396 "SMO MUT" "Bleomycin_IC_50" 0.431850210390872 0.821209960265379 -1.83589715652175 0.793493043041962 0.977826093138261 -0.49617943843678 0.251738712116497 0.875707386589409 -2.56720138266 "CTNNB1 MUT" "AZD6244_IC_50" 0.695529974027993 0.913718445479852 -0.26738227406417 0.793649532537087 0.977826093138261 -0.162791644483015 0.972284002717322 0.99742775226181 0.0235545372344605 "KIT MUT" "KU.55933_IC_50" 0.976691187074444 0.996276778834563 0.0184088118811879 0.793719554684582 0.977826093138261 0.146902102574561 0.943867569795687 0.995317308813434 -0.0440759926228748 "CTNNB1 MUT" "XMD8.85_IC_50" 0.87133361670407 0.970078206086103 -0.121632881944445 0.794124421643439 0.977826093138261 0.167897777509455 0.632526831341665 0.952523560833852 0.392833707434235 "CCND1 MUT" "VX.680_IC_50" 0.354098243151722 0.785252181551816 0.717506205399059 0.794278283480301 0.977826093138261 0.134263356871735 0.598236488352026 0.94937477774851 0.489924374776717 "FLCN MUT" "Gemcitabine_IC_50" 0.0838132085451655 0.500295367140933 3.14330149650349 0.794370816314348 0.977826093138261 0.317227152188194 0.47480946825678 0.929844139269115 1.56572544734082 "PDGFRA MUT" "Etoposide_IC_50" 0.436236606189469 0.823808548892323 -0.856257961871742 0.794383348001699 0.977826093138261 -0.186613400599264 0.507142048454556 0.936562389753569 -0.701833613653203 "BRCA2 MUT" "RDEA119_IC_50" 0.173616430722496 0.65113493295882 1.59625284890659 0.794467766961416 0.977826093138261 0.278740400688552 0.0614457896356164 0.702860976445846 1.88277314209478 "FGFR3 MUT" "WZ.1.84_IC_50" 0.222101304309874 0.694291335296019 -1.449638707483 0.794568029912464 0.977826093138261 -0.256594821917658 0.458118084191632 0.92656495233566 -0.839279018209562 "MLLT3 MUT" "AZ628_IC_50" 0.788150282832761 0.946449577332088 -0.233247318181818 0.794611149001181 0.977826093138261 0.16695015384497 0.519761907738179 0.939635632721979 0.50933861644139 "KDM6A MUT" "Cytarabine_IC_50" 0.830033615323556 0.958015830101332 -0.108116841130604 0.794645398088514 0.977826093138261 0.100366737260128 0.720139145478086 0.965366905809944 -0.172824378025945 "EGFR MUT" "ABT.263_IC_50" 0.841500200302745 0.959741495283223 0.0948051480044342 0.794645569756077 0.977826093138261 -0.11112842953172 0.502488323860415 0.934042323734638 -0.289187356407651 "CDKN2C MUT" "PD.173074_IC_50" 0.828284908990929 0.958015830101332 0.111340464426876 0.79468459524425 0.977826093138261 -0.11425461521592 0.580163915945211 0.949294892873838 0.279745982172163 "MLLT3 MUT" "BI.2536_IC_50" 0.628513448215297 0.891947858940054 0.352936536585367 0.79480284204475 0.977826093138261 0.111850036950189 0.802437240015759 0.976365695720597 0.199518310704653 "CDH1 MUT" "SL.0101.1_IC_50" 0.474950400386651 0.834593293595933 -0.330777547065332 0.794956725393995 0.977826093138261 -0.106504098882066 0.114613959812147 0.799692247086917 -0.762915282113095 "PIK3CA MUT" "CCT007093_IC_50" 0.516922673586506 0.852353345422823 -0.102021857511839 0.79511373654194 0.977826093138261 -0.0412316225448265 0.658424281343307 0.958313128388245 -0.0770815287469632 "ERBB2 MUT" "EHT.1864_IC_50" 0.458713093951356 0.828966839128293 -0.238510167050691 0.795116626817588 0.977826093138261 -0.0863289649835093 0.263969708937466 0.877052916121269 -0.372896316884627 "EZH2 MUT" "Gemcitabine_IC_50" 0.840042175260449 0.959424448728358 0.311068982456142 0.795120755396592 0.977826093138261 0.267475447343679 0.852830874549178 0.984631915507353 -0.288313244586393 "MAP2K4 MUT" "Bortezomib_IC_50" 0.567414239121182 0.872389778906173 -0.64803936643836 0.795152918778336 0.977826093138261 -0.240936547732793 0.904186654268111 0.988746233284632 -0.151088684226209 "BRCA1 MUT" "Axitinib_IC_50" 0.841345763595424 0.959741495283223 0.178665241904764 0.79535945325001 0.977826093138261 -0.19604580930566 0.977635214766028 0.99751589411042 -0.0218955590438605 "EGFR MUT" "ZM.447439_IC_50" 0.451699276300831 0.828509891052426 0.262039271803401 0.795406060347861 0.977826093138261 0.0719494026946608 0.981072928385591 0.997927920855851 0.00818455355729845 "CDK4 MUT" "CCT007093_IC_50" 0.536264847476938 0.859994020980345 0.210674149659863 0.795609437328929 0.977826093138261 0.088541260104089 0.793852671680703 0.975393509832241 0.0953817093451371 "KIT MUT" "NVP.BEZ235_IC_50" 0.466188786203505 0.830665605381938 -0.564339884231534 0.795688745268646 0.977826093138261 0.145162439438666 0.880444227601279 0.988301482344111 -0.111591915514201 "SMARCB1 MUT" "PF.562271_IC_50" 0.309775600673212 0.757046299071613 -1.10369269137931 0.795940968382074 0.977826093138261 -0.228612047244937 0.278564446213382 0.885713545160236 -1.16996436837485 "NOTCH1 MUT" "GDC0941_IC_50" 0.740140532089211 0.929570057037101 0.192461524008349 0.796005247966746 0.977826093138261 -0.124518127507726 0.627170545528193 0.952105511848497 0.301205403127429 "MYCN MUT" "LFM.A13_IC_50" 0.936802508689958 0.988375382416448 -0.0199575493716335 0.796090307817422 0.977826093138261 -0.0630056380489082 0.209299328665578 0.853446327418758 -0.364749900143137 "NRAS MUT" "Bicalutamide_IC_50" 0.920844535379335 0.986016435821543 0.00987795994659552 0.796159895669398 0.977826093138261 -0.0252268089448016 0.855664565831531 0.984631915507353 -0.0193697278062445 "CTNNB1 MUT" "BI.2536_IC_50" 0.72742059633811 0.926041868997115 -0.326023515463919 0.796434409510597 0.977826093138261 0.142353826081236 0.861161771328793 0.985524480087535 0.188491444510931 "CDK4 MUT" "ZM.447439_IC_50" 0.142349661501824 0.614587916284734 0.748017359126985 0.796483152719743 0.977826093138261 0.104881113271843 0.134804413078461 0.828635349589072 0.754851697980376 "MSH2 MUT" "AZD6482_IC_50" 0.21238898027591 0.686649630080219 -0.872379567944252 0.796764748338154 0.977826093138261 -0.153058532013429 0.0420840462245862 0.658180729724545 -1.39842273705531 "CCND1 MUT" "Axitinib_IC_50" 0.224416860943885 0.696139064632428 0.442377379365082 0.796793798356874 0.977826093138261 -0.0797750912368342 0.325604034914426 0.900918773778407 0.339176501683826 "CCND2 MUT" "BMS.708163_IC_50" 0.763402608587473 0.936244886169491 0.258920587053572 0.79683210290958 0.977826093138261 0.221556805347802 0.717155388277161 0.963986227227103 0.315263547422811 "MYCN MUT" "AICAR_IC_50" 0.895683598723182 0.977104649723106 0.0539449101796401 0.796844654268987 0.977826093138261 0.0974892307623607 0.820582191938996 0.977383317127464 -0.105548872043688 "CTNNB1 MUT" "Gefitinib_IC_50" 0.559375125081618 0.869446457391816 0.266138721377457 0.796847423694247 0.977826093138261 0.106098305878436 0.868146111433071 0.987439092273582 -0.0744870961783781 "KDM5C MUT" "NVP.BEZ235_IC_50" 0.917238507445503 0.984975746996111 0.0928567589641439 0.797074331145093 0.977826093138261 0.1657223568868 0.977002168442182 0.99742775226181 -0.024290978861662 "PTEN MUT" "Thapsigargin_IC_50" 0.671372823223277 0.906916702390321 0.143395189167862 0.797091852269171 0.977826093138261 0.0677885035394063 0.931419229260127 0.994235539701634 0.0306072961110601 "TET2 MUT" "BI.D1870_IC_50" 0.120277638539118 0.578669821377548 -1.44598879961837 0.797146582791767 0.977826093138261 -0.209517835487707 0.930749589156225 0.99422596912377 -0.094487242121516 "FLT3 MUT" "GSK269962A_IC_50" 0.859157769514247 0.966322414954601 -0.23804442176871 0.797249528650171 0.977826093138261 0.325830510962126 0.957911364749845 0.99641548698706 -0.0709133313275857 "PIK3R1 MUT" "Cytarabine_IC_50" 0.40771039012943 0.809352267869285 0.585007858205368 0.797256923816479 0.977826093138261 -0.13739726271202 0.739546461229788 0.96672489654949 0.216763286858681 "ALK MUT" "FTI.277_IC_50" 0.713970480767425 0.91988693852899 0.286067113793103 0.79740382892072 0.977828624694866 0.182566443136773 0.386844562851384 0.915662729926209 -0.90289422300229 "MLLT3 MUT" "ZM.447439_IC_50" 0.82992764498544 0.958015830101332 -0.0823684504928308 0.797627507508567 0.977828624694866 -0.078036313751789 0.94044214030128 0.995120990231635 0.0284642816462975 "PTEN MUT" "CMK_IC_50" 0.508794122194117 0.848726038823513 -0.177883827956989 0.797653934610182 0.977828624694866 -0.0642075902112295 0.63342557508597 0.952523560833852 -0.142030842813426 "JAK2 MUT" "Dasatinib_IC_50" 0.712731210167237 0.919646314953749 0.835312366325364 0.797902302931555 0.977828624694866 -0.47720032715761 0.383427168642014 0.915134825237766 2.12346833040764 "MET MUT" "BIBW2992_IC_50" 0.980924533210159 0.996407500793711 -0.0132416940683417 0.797945732014211 0.977828624694866 -0.13613082850129 0.728251541297521 0.965402608571648 0.177553335714975 "FLT3 MUT" "Vinorelbine_IC_50" 0.255266392478954 0.720311238267775 -1.15512173875433 0.798151782256971 0.977828624694866 0.19362416906191 0.500458802870261 0.934042323734638 -0.677015234001579 "APC MUT" "Obatoclax.Mesylate_IC_50" 0.837891802063902 0.959212868273494 -0.0870009510811763 0.798600826406529 0.977828624694866 -0.0830184888921277 0.183838108700205 0.851001889249827 -0.659496703098949 "KDM5C MUT" "VX.680_IC_50" 0.593345402984067 0.878261059495448 -0.706607297945206 0.798833409820755 0.977828624694866 0.219918074840305 0.710638649183708 0.962630898212352 -0.505089146330003 "VHL MUT" "Vinblastine_IC_50" 0.701392784115008 0.915500829364901 0.244027522552777 0.799069854986213 0.977828624694866 0.118006952423296 0.788377987064724 0.975265472692061 0.173845377806126 "FLCN MUT" "NU.7441_IC_50" 0.464537829234507 0.829490249358073 0.525145938613859 0.79913755723408 0.977828624694866 0.160321871980875 0.781208186762773 0.973017078278378 0.270771658861411 "KRAS MUT" "RO.3306_IC_50" 0.285314836052367 0.740302864659114 0.188142568417521 0.799295801171999 0.977828624694866 -0.0455226606422694 0.328048120032344 0.902810042912437 -0.201354125013397 "FGFR3 MUT" "BMS.754807_IC_50" 0.425902349276283 0.819381892124907 -1.06076951858303 0.799386708353316 0.977828624694866 -0.2823763540909 0.384539535145263 0.915331032347709 -1.13284827472166 "SMARCA4 MUT" "JNK.9L_IC_50" 0.527784479350834 0.855147571292734 0.276579288461539 0.799414112912596 0.977828624694866 0.0867897956785783 0.440624820903084 0.924472815010418 -0.383041820200769 "RB1 MUT" "NU.7441_IC_50" 0.95575077320699 0.992751183257459 -0.0119296887311442 0.799503692196124 0.977828624694866 -0.0488769598863733 0.869834908347579 0.98753907730331 0.0376796441265816 "EGFR MUT" "A.443654_IC_50" 0.349426688591085 0.784966682190403 0.610038496503493 0.799507057164807 0.977828624694866 0.106884544896995 0.115864173013939 0.802355750183445 1.05637678167093 "KIT MUT" "ZM.447439_IC_50" 0.349428993624671 0.784966682190403 -0.750342247058826 0.799547808048109 0.977828624694866 -0.162186130285171 0.22543242074387 0.86643108387559 -0.925515010622285 "RUNX1 MUT" "PD.0332991_IC_50" 0.889190217354767 0.975527896272722 -0.159041565426995 0.799593077306938 0.977828624694866 -0.230447835272869 0.728534525897041 0.965402608571648 -0.367403170378071 "MSH2 MUT" "Bexarotene_IC_50" 0.575038341601048 0.872620551543038 -0.342401470426069 0.799788636003316 0.977828624694866 -0.139173814461449 0.294620799099325 0.894167310052 -0.617048626709953 "BRCA2 MUT" "PD.173074_IC_50" 0.406551505567559 0.809185101063535 0.599964019607844 0.799827808565339 0.977828624694866 -0.15777297111363 0.912674621148446 0.99082410867764 0.0732356018027111 "HRAS MUT" "PD.173074_IC_50" 0.709481554820741 0.918499371481488 0.241176110019647 0.799918931243904 0.977828624694866 0.140761654189261 0.937901931020541 0.994831655017307 -0.0462886756043986 "TSC1 MUT" "ZM.447439_IC_50" 0.571832424228145 0.872389778906173 -0.640071056640615 0.799946771592263 0.977828624694866 -0.228279542504714 0.854912092828658 0.984631915507353 -0.195356442682579 "SETD2 MUT" "Bleomycin_IC_50" 0.605867944557666 0.882603260686518 1.20533939130436 0.800200161154054 0.977828624694866 -0.487497770425966 0.547977494903998 0.947060194029534 1.35330946948255 "CTNNB1 MUT" "SB.216763_IC_50" 0.795114595184088 0.948646027682356 -0.106156140055165 0.800225560543212 0.977828624694866 -0.100139674574588 0.458923567867284 0.927632358897555 -0.319124073235753 "CDKN2A MUT" "JNK.9L_IC_50" 0.0355023200761105 0.347105523744792 -0.241488709034337 0.800236163878768 0.977828624694866 -0.0238020553279336 0.815701478612269 0.977383317127464 -0.0304902765982426 "MS-HL MUT" "S.Trityl.L.cysteine_IC_50" 0.566311878382338 0.872389778906173 0.205604427716253 0.800336056487254 0.977828624694866 0.0499877388525381 0.648515538562921 0.957493413330814 0.188261909992061 "SETD2 MUT" "S.Trityl.L.cysteine_IC_50" 0.411280472648181 0.812480994891775 1.2158229829932 0.80048362280113 0.977828624694866 -0.206938595714283 0.359024760232933 0.91161229252998 1.39525468641824 "RB1 MUT" "NVP.BEZ235_IC_50" 0.303497901691565 0.753137804459424 0.234377707653107 0.800557312874782 0.977828624694866 -0.0428680480356264 0.37292444178338 0.913948248824328 0.214828219851606 "ALK MUT" "Dasatinib_IC_50" 0.572723933382035 0.872536164174514 1.10992873287671 0.800659653893532 0.977828624694866 -0.414117678203737 0.95190026006735 0.995669074626174 -0.120813783370093 "TSC1 MUT" "BI.D1870_IC_50" 0.888324889351707 0.975301439279579 0.160100226666671 0.80066298965014 0.977828624694866 0.248862497310822 0.790466095993244 0.975393509832241 0.286944395819515 "SETD2 MUT" "Rapamycin_IC_50" 0.789623853447 0.947425163069223 0.571008050335563 0.800809630827226 0.977828624694866 0.469884021838155 0.696662204803037 0.961100601384891 0.854258994857753 "EWS_FLI1 MUT" "PLX4720_IC_50" 0.900409433879784 0.979367566722151 0.0640844187866936 0.800856112172459 0.977828624694866 -0.122301272111091 0.743213405321951 0.966920292106991 0.176428130514153 "BRCA1 MUT" "DMOG_IC_50" 0.444797183377399 0.825606373270691 0.614147590987864 0.800877738382838 0.977828624694866 0.182664665968949 0.756187457972651 0.969901216545994 0.236123002001823 "MLL_AFF1 MUT" "Metformin_IC_50" 0.255285321963993 0.720311238267775 -1.15993897338403 0.801036825181083 0.977828624694866 -0.243822141388529 0.998954224940744 0.999751228014461 0.00132655618625059 "NRAS MUT" "Doxorubicin_IC_50" 0.20803824930864 0.681515194433801 -0.39314064601691 0.801142767884472 0.977828624694866 0.0508022852894497 0.599661991870972 0.949657634568742 -0.178458987381945 "MDM2 MUT" "AZD.0530_IC_50" 0.678728919008862 0.908837606441414 -0.377661527210884 0.801150462685838 0.977828624694866 0.198421105461602 0.97131688622542 0.99742775226181 0.0309263121871512 "CDK6 MUT" "DMOG_IC_50" 0.541561114927395 0.861627420578681 0.367011285631179 0.801232618446025 0.977828624694866 0.136089323095148 0.451849423829068 0.925809648901546 0.451530869540278 "NF2 MUT" "Rapamycin_IC_50" 0.612441379783539 0.88496040166963 -0.491442072413797 0.801457935583682 0.977828624694866 0.215368865635699 0.910397273782984 0.990141873133243 -0.121256571247469 "BRAF MUT" "AZD8055_IC_50" 0.973622561738831 0.995472410100622 0.00693062693498428 0.801514691074572 0.977828624694866 0.0448125928611209 0.602972812443045 0.949657634568742 -0.124566337704199 "STK11 MUT" "GSK269962A_IC_50" 0.543132212207548 0.862633715268747 -0.633850821917804 0.801594890768838 0.977828624694866 -0.245422380831699 0.534959981630457 0.943443271455699 -0.733543049790974 "APC MUT" "Camptothecin_IC_50" 0.000114363230626724 0.0106911563283782 1.59347858226454 0.801711295539951 0.977828624694866 0.0694529219739419 0.277905676605562 0.885251188642035 0.489183781968912 "BRAF MUT" "Bicalutamide_IC_50" 0.249375922359535 0.71580012538195 -0.101239592476488 0.801773228806217 0.977828624694866 -0.0231181594595649 0.226035502873516 0.86643108387559 0.119297003737984 "TSC1 MUT" "PF.562271_IC_50" 0.274935157484506 0.73402283606276 1.18627661896553 0.802052223414643 0.978034573135445 0.222515301608041 0.249174011415612 0.875707386589409 1.22589059519913 "FLCN MUT" "Rapamycin_IC_50" 0.645264425121165 0.896946839802954 0.805711781144776 0.802885048816844 0.978915721930587 -0.374588438901288 0.763549683339789 0.969901216545994 -0.941703268791644 "EWS_FLI1 MUT" "Axitinib_IC_50" 0.0829310229572867 0.498552626562699 -0.834059856033306 0.802997743311112 0.978918731413314 0.109099898999658 0.975603800968157 0.99742775226181 -0.0149374312162585 "CDKN2a(p14) MUT" "Tipifarnib_IC_50" 0.017611551513781 0.243626462607304 -0.460107156887319 0.803211943590604 0.978976517129125 -0.0337330195156326 0.465448541004664 0.929276781658587 -0.155713154193926 "MSH2 MUT" "Docetaxel_IC_50" 0.834594576283355 0.959122768755193 0.143618807017543 0.803270460617563 0.978976517129125 -0.128792038017609 0.636750365190037 0.953101495776253 -0.315176852740141 "BCR_ABL MUT" "IPA.3_IC_50" 0.64202252714162 0.896094514063559 0.481426546247827 0.803375842454348 0.978976517129125 -0.259898572995671 0.0238295950541077 0.568899552891211 2.21248222075985 "CDH1 MUT" "GW843682X_IC_50" 0.62513782212687 0.890724841246629 -0.537299585616435 0.803609895030199 0.979081969520297 -0.144792496020726 0.950598432396913 0.995668765770473 -0.0724218058132917 "MYC MUT" "GSK269962A_IC_50" 0.39085171941222 0.801837403580487 0.414319572205883 0.804006094803923 0.979081969520297 0.114078284357921 0.916357181320233 0.992403322408462 0.0533948592562659 "PIK3R1 MUT" "GNF.2_IC_50" 0.472264292795362 0.833832839824177 0.406301810996566 0.804015191099914 0.979081969520297 0.133564003402973 0.400632636728908 0.916589616820582 0.478565039965248 "MSH6 MUT" "AZD6244_IC_50" 0.387748549439246 0.79990589258303 -0.794584225918227 0.804113492594599 0.979081969520297 0.207637783929846 0.249165825713918 0.875707386589409 -0.940338137928036 "HRAS MUT" "NVP.BEZ235_IC_50" 0.329793277053945 0.771167481178538 -0.675583813999996 0.804200230069979 0.979081969520297 0.124761486478657 0.722999627280526 0.965402608571648 -0.232879295563028 "SETD2 MUT" "ABT.263_IC_50" 0.442019375041255 0.825166478070376 1.18464914257811 0.804297082527824 0.979081969520297 0.345763982398382 0.889026336696251 0.988301482344111 -0.186715397399923 "BRCA1 MUT" "WO2009093972_IC_50" 0.797572493895148 0.949524851900765 0.198602953703703 0.804312836896844 0.979081969520297 0.172752708164051 0.834276771661776 0.981482581683432 0.15928302295476 "KIT MUT" "PD.173074_IC_50" 0.870823881601641 0.969753842320273 0.117585098039216 0.804427004570459 0.979081969520297 0.153282833353542 0.572935518473129 0.949294892873838 0.377933423739369 "MAP2K4 MUT" "Sorafenib_IC_50" 0.539887024926331 0.861547651912703 -0.570758238907847 0.804508050466351 0.979081969520297 -0.220921490816897 0.508869687800194 0.938147991955214 -0.738783847287444 "IDH1 MUT" "RO.3306_IC_50" 0.51866265801453 0.852547767172312 -0.671964765624994 0.804564825307863 0.979081969520297 -0.244277899460522 0.617840612079133 0.950394619652337 -0.522262965997796 "PTEN MUT" "Salubrinal_IC_50" 0.977646382940074 0.996276778834563 0.00753952215032343 0.804749193178548 0.979124386072475 0.0556708887740941 0.71583008910366 0.963225306262061 0.106728084767871 "CDKN2A MUT" "AZD8055_IC_50" 0.00576223506610767 0.131553752241908 -0.348332877507456 0.804820179971745 0.979124386072475 -0.0254122501097767 0.0955789353479617 0.77097828178369 -0.23293203055335 "EP300 MUT" "Obatoclax.Mesylate_IC_50" 0.98186384002675 0.996677650391767 0.0303074134727056 0.805262924853852 0.979385126414584 0.24183296628386 0.868940384647461 0.98751437004641 -0.209892313541418 "ERBB2 MUT" "GDC.0449_IC_50" 0.510790474202947 0.849393770898084 0.204012638888888 0.805438973491037 0.979385126414584 -0.0701167440073321 0.570487079139687 0.949294892873838 0.185608675767765 "SMAD4 MUT" "Bicalutamide_IC_50" 0.284828059547706 0.740302864659114 -0.126358845960233 0.80549726889747 0.979385126414584 -0.0285568359173271 0.979914483264976 0.997827228172038 0.00299493823557631 "KDM5C MUT" "Pazopanib_IC_50" 0.676685055436177 0.908720747099578 0.394195336823741 0.805544820540345 0.979385126414584 0.198200939337065 0.967255526279846 0.997173634484198 -0.0353241544327113 "CCND3 MUT" "Elesclomol_IC_50" 0.934668920438041 0.987719500524779 0.1264949886148 0.805585896684893 0.979385126414584 0.315011514590913 0.815785256790132 0.977383317127464 0.337929048486147 "EP300 MUT" "Dasatinib_IC_50" 0.507328138852564 0.847796212975596 -1.83859323129252 0.805748822504762 0.979449123003667 0.561785771110827 0.603103912039452 0.949657634568742 1.25556694019626 "MLL_AFF1 MUT" "PAC.1_IC_50" 0.0998108810520808 0.5374999166548 -2.0098695756522 0.805899840606937 0.97949862931849 -0.254909218081903 0.41560911724635 0.92211126027385 -0.965621426698966 "CDKN2A MUT" "WO2009093972_IC_50" 0.0851729731271166 0.503679085433888 -0.253959685854605 0.806090803801438 0.979596665101337 -0.0337910297221562 0.699081559346138 0.961100601384891 -0.0639424917829067 "TET2 MUT" "Pyrimethamine_IC_50" 0.171465282015797 0.649721929411943 -1.8420554761905 0.806692375497814 0.979712931274545 -0.281865186226291 0.305961255310022 0.896682870760742 -1.68745963480343 "MLL_AFF1 MUT" "ATRA_IC_50" 0.00826582671787555 0.159584363220549 -3.21692098282445 0.806730616684419 0.979712931274545 -0.239818251147417 0.398031479992178 0.916480913435499 -0.916536939841647 "MLH1 MUT" "Thapsigargin_IC_50" 0.745419121220026 0.93064627954821 -0.27255357345133 0.806747141868165 0.979712931274545 -0.158509139251376 0.984523219458415 0.998124818853736 0.015930593926787 "IDH1 MUT" "AS601245_IC_50" 0.974301794813597 0.995601684471241 -0.0411034817391298 0.806801706454157 0.979712931274545 0.248749593290602 0.699749043512032 0.961100601384891 0.489377246545453 "ERBB2 MUT" "Mitomycin.C_IC_50" 0.395804915872435 0.804008910182289 0.463105526575629 0.80682384108683 0.979712931274545 -0.107190408055777 0.590859538919997 0.949294892873838 -0.302331725600842 "NF2 MUT" "MG.132_IC_50" 0.161303621434541 0.636874757939932 -1.06355472222222 0.806848370604889 0.979712931274545 -0.169386667468763 0.833293390587104 0.981482581683432 -0.163514969305948 "MYCL1 MUT" "Bortezomib_IC_50" 0.346041664520132 0.782020929432191 0.874449925287362 0.806959701106839 0.979714163435385 -0.187090875367243 0.763176258479147 0.969901216545994 -0.276863110997871 "CCND1 MUT" "Z.LLNle.CHO_IC_50" 0.742628554040821 0.929570057037101 0.175682839201877 0.807140090959793 0.979725047472661 -0.122551008125456 0.891197891638705 0.988301482344111 -0.0828343372842258 "TET2 MUT" "AS601245_IC_50" 0.517463160994829 0.852353345422823 0.674797470383267 0.807299404751279 0.979725047472661 0.205291040334093 0.838071866999671 0.981704379975756 0.258140847723451 "FLCN MUT" "Z.LLNle.CHO_IC_50" 0.46622052257085 0.830665605381938 0.767314060295788 0.807412836632556 0.979725047472661 0.235927471006634 0.50255909044411 0.934042323734638 -1.21326601440149 "MET MUT" "PAC.1_IC_50" 0.50585225722231 0.847796212975596 -0.349538418888534 0.807521469604478 0.979725047472661 0.107595651763729 0.214544864397848 0.859434499119166 -0.629720825713223 "MYC MUT" "Gefitinib_IC_50" 0.993796513390452 0.998970779334534 -0.00205272835865653 0.8075714976316 0.979725047472661 -0.0581368152802781 0.883352537821049 0.988301482344111 0.0365089506045318 "EGFR MUT" "AZD.0530_IC_50" 0.813811025514382 0.953913887475092 0.161171877011495 0.807630567790491 0.979725047472661 -0.142608734818923 0.309038479690852 0.89718581932126 0.657028162577228 "BCR_ABL MUT" "Elesclomol_IC_50" 0.673428813683232 0.908308454633653 0.460707860000007 0.808145875502164 0.980033521293934 -0.26673330475421 0.904201252427188 0.988746233284632 0.128031280607316 "NF2 MUT" "PD.173074_IC_50" 0.616418854524341 0.885815598771911 0.160772865835988 0.808151968589913 0.980033521293934 -0.0671950712698921 0.90294748615936 0.988746233284632 -0.038461148720107 "CDK6 MUT" "Pyrimethamine_IC_50" 0.502563077821533 0.846565396668817 0.9042112585034 0.808517229595544 0.980033521293934 0.275011256184754 0.154485505797593 0.835611501078903 2.354074056041 "FGFR2 MUT" "CEP.701_IC_50" 0.448882166290971 0.827360921900611 0.990395555977228 0.80867947473981 0.980033521293934 -0.233945439850434 0.166993557699537 0.84067330207935 2.3108690809547 "CDK6 MUT" "AZD6244_IC_50" 0.590414396252168 0.876687887161929 0.405658753138075 0.808805525827282 0.980033521293934 0.165770368924734 0.194473420358397 0.851001889249827 0.872322313308108 "STK11 MUT" "S.Trityl.L.cysteine_IC_50" 0.8135428965247 0.953913887475092 -0.221985390378007 0.808904159695055 0.980033521293934 -0.124466799310069 0.962763782650142 0.996771409852636 0.0509663313745854 "STK11 MUT" "SL.0101.1_IC_50" 0.362469440220478 0.787270200866664 0.241325730357469 0.808916732303595 0.980033521293934 0.0558803927460693 0.445661058114307 0.925809648901546 0.207497432562419 "MDM2 MUT" "Mitomycin.C_IC_50" 0.334290988047061 0.773264085106582 0.6822514675485 0.809012502775896 0.980033521293934 -0.133372163186352 0.521722118824302 0.939635632721979 0.438813085363254 "JAK2 MUT" "WH.4.023_IC_50" 0.414661098997494 0.813999705954707 1.68004493515357 0.809042803355365 0.980033521293934 0.431576374611958 0.35834469697107 0.91161229252998 2.18033075639353 "CDK6 MUT" "BMS.708163_IC_50" 0.854264373039819 0.964541653680809 0.0795337624434401 0.809047375919825 0.980033521293934 0.104983934232504 0.81363920368506 0.977383317127464 0.102757537066978 "APC MUT" "A.770041_IC_50" 0.605485032792289 0.882603260686518 -0.405757926573429 0.809101754789776 0.980033521293934 -0.159600146766331 0.940901295055184 0.995134500581766 0.0655950499532226 "NF1 MUT" "RO.3306_IC_50" 0.703264931475504 0.915500829364901 0.121998898743533 0.809312581048801 0.980033521293934 0.0742994046989133 0.24817615132174 0.875707386589409 0.401447088881119 "CDKN2A MUT" "Rapamycin_IC_50" 0.126949341073812 0.587206821914858 -0.553873197762818 0.809366883241508 0.980033521293934 -0.0801724248425378 0.987047052951211 0.998124818853736 -0.00691236419553428 "VHL MUT" "WO2009093972_IC_50" 0.112356517914688 0.563432092377384 -0.872109857476632 0.809429780282739 0.980033521293934 -0.119750167101841 0.713971376708989 0.962630898212352 -0.21547083810332 "GNAS MUT" "KU.55933_IC_50" 0.403950802455317 0.807904911469051 0.373179441117762 0.809777261281035 0.980111603611955 0.0955337825369098 0.60567378822591 0.949657634568742 0.227226794704504 "MSH2 MUT" "ABT.263_IC_50" 0.556975727981451 0.868264251396044 -0.486207605804448 0.809842866493077 0.980111603611955 -0.17959543305944 0.388083681872188 0.915926348152589 0.624640605522614 "KDM6A MUT" "AZD8055_IC_50" 0.165520337628194 0.64339386611283 -0.472019440354464 0.809882115776647 0.980111603611955 0.0642051497082246 0.211595420714888 0.855272470862467 -0.424517877492515 "CDK4 MUT" "Erlotinib_IC_50" 0.908706536900079 0.981529929795606 0.139940836363637 0.809935712071629 0.980111603611955 0.266319992654218 0.832729492799631 0.981482581683432 0.253095353433217 "CCND1 MUT" "NVP.TAE684_IC_50" 0.427948593511572 0.820918238409269 0.573088243055558 0.810285551125172 0.98031523289953 0.145027194828946 0.449196218210458 0.925809648901546 0.637750603127852 "EGFR MUT" "Vinorelbine_IC_50" 0.68276939446566 0.910084943794605 0.176053599984446 0.81048888265296 0.98031523289953 -0.0761040709106674 0.311990862201193 0.898149383211927 0.449214224113738 "NOTCH1 MUT" "AZD6482_IC_50" 0.892238310220056 0.975972789421281 0.0675309240282672 0.810602222041987 0.98031523289953 -0.10382881210589 0.977544710206005 0.99751589411042 -0.0151048033748441 "BRAF MUT" "Thapsigargin_IC_50" 0.0780645566644813 0.486980385654137 -0.717849535005219 0.810715168364628 0.98031523289953 -0.0819812108653162 0.432687598851282 0.922569292988365 -0.3720603236238 "EP300 MUT" "PF.4708671_IC_50" 0.547879161228814 0.863770680855317 -0.408958164794012 0.810953717001285 0.98031523289953 -0.161033412861016 0.522028909108752 0.939821354509391 -0.438932701633585 "NF2 MUT" "ZM.447439_IC_50" 0.90176674927653 0.979694707150557 0.0439550347725299 0.811036129683357 0.98031523289953 0.0682909496625576 0.830119771558092 0.981482581683432 0.0771145434731351 "ERBB2 MUT" "AZD.2281_IC_50" 0.0606889098556321 0.444487381006596 0.712246821862348 0.811070315398864 0.98031523289953 0.0710565803824743 0.937993914313756 0.994831655017307 -0.0278187742371033 "EGFR MUT" "Dasatinib_IC_50" 0.644190536572326 0.896446680008675 0.580841727272727 0.811085483313444 0.98031523289953 -0.245416950056591 0.0923426086660391 0.76758746139711 1.8572904269031 "MYCL1 MUT" "Sorafenib_IC_50" 0.814164966042231 0.953913887475092 0.179363920962201 0.811124041025841 0.98031523289953 -0.175797714505876 0.486849310878078 0.933639405738697 -0.568906866279288 "MSH2 MUT" "MS.275_IC_50" 0.857121824451774 0.965389844382525 0.16289943598616 0.811207819680064 0.98031523289953 -0.179956873896287 0.691771992877431 0.961100601384891 0.380163825068254 "BRAF MUT" "Methotrexate_IC_50" 0.282323292532868 0.738966448860715 0.345793521394882 0.811428523283639 0.980341658250847 -0.0644581996737463 0.364040799908028 0.9127742360201 -0.275265512668549 "MS-HL MUT" "Methotrexate_IC_50" 0.149760038163205 0.62466549367193 -0.445143428660388 0.811559907129901 0.980341658250847 0.0565133805759554 0.524800567724293 0.940554660491705 0.170605277234902 "CDKN2a(p14) MUT" "Nilotinib_IC_50" 0.268037078510102 0.731489745211169 -0.162307888712266 0.811560845789914 0.980341658250847 0.0290746740403699 0.986043154223818 0.998124818853736 -0.00257507814059046 "NF2 MUT" "Temsirolimus_IC_50" 0.927937488606979 0.986593180452362 -0.0459304936257964 0.812030979584028 0.980423832905026 -0.0929539310490589 0.833622311444355 0.981482581683432 0.108237070457168 "EZH2 MUT" "Cisplatin_IC_50" 0.956002652737222 0.992896685646038 0.0411076316793896 0.812065632728377 0.980423832905026 -0.153027239507922 0.825676429170491 0.980029315589217 -0.156788594794559 "BRCA1 MUT" "PD.173074_IC_50" 0.805467284443148 0.952510646223648 0.178080882352941 0.81207417335815 0.980423832905026 0.14842751838833 0.938349414964316 0.994831655017307 0.0512386753409612 "FBXW7 MUT" "LFM.A13_IC_50" 0.872463017952141 0.970405187398056 -0.0385950696150691 0.812173929054148 0.980423832905026 -0.0540158954484355 0.511395175954462 0.939086342216131 -0.163485485084207 "EP300 MUT" "PD.173074_IC_50" 0.523326267068042 0.854075976778526 0.532276712328775 0.812180851107114 0.980423832905026 -0.170189865532677 0.495343639394952 0.933639405738697 0.519741535329938 "FLT3 MUT" "Salubrinal_IC_50" 0.0996746393485856 0.5374999166548 -1.63957557077623 0.81253812988669 0.980596729352485 -0.197304770721955 0.282094392209227 0.887872038823822 -1.07214411988467 "STK11 MUT" "Bicalutamide_IC_50" 0.835518790191097 0.959122768755193 -0.0268551069921638 0.812563079356086 0.980596729352485 0.0292330924687109 0.490507791957144 0.933639405738697 0.0889136400632627 "NOTCH1 MUT" "SL.0101.1_IC_50" 0.0097937228247905 0.175358976626944 -0.848910202076889 0.812786225709424 0.980596729352485 0.0711815074211744 0.616856396303448 0.950247055931602 -0.172757487263676 "BRCA2 MUT" "KIN001.135_IC_50" 0.736212145948099 0.928872455997232 0.185729966329964 0.812892648488027 0.980596729352485 0.128340245608485 0.531555072252008 0.94320946427311 0.327990327496601 "MYC MUT" "Tipifarnib_IC_50" 0.47438181516125 0.834460661638643 0.253812956232037 0.812903633008985 0.980596729352485 0.0562432399776738 0.854891147597346 0.984631915507353 -0.067525769668034 "BRCA2 MUT" "S.Trityl.L.cysteine_IC_50" 0.446198536633364 0.825892730562573 1.12731495578232 0.813002504527627 0.980596729352485 -0.192240051275558 0.180249425453164 0.848722027112292 2.04332614941768 "MYC MUT" "X17.AAG_IC_50" 0.577080687648099 0.873750949722175 0.201292237114987 0.813145503036097 0.980596729352485 0.0752577393630631 0.963910205917864 0.997051031866061 -0.0150100746954712 "MDM2 MUT" "LFM.A13_IC_50" 0.748070562367367 0.932115582035752 0.113313051146384 0.81325123704247 0.980596729352485 0.0785257902845383 0.623567288129702 0.950496524771391 0.17182343710967 "EGFR MUT" "CEP.701_IC_50" 0.262237760251948 0.724847042887503 0.441106701581028 0.813416946003445 0.980596729352485 0.0684787628509103 0.593853513908248 0.949294892873838 0.199455007702915 "KDM5C MUT" "GSK269962A_IC_50" 0.984751988823332 0.996761159418739 0.0256390476190492 0.813612418057829 0.980596729352485 -0.296324921263376 0.988493744139891 0.998386550859362 -0.0191270196729461 "CDKN2a(p14) MUT" "CMK_IC_50" 0.252459779951866 0.717470497840808 -0.242421008750001 0.813660661826104 0.980596729352485 0.0491944149609925 0.613263853916606 0.949930222127033 0.124843232824799 "NRAS MUT" "Bortezomib_IC_50" 0.978140814442621 0.996276778834563 -0.0139676445021661 0.814083455723937 0.980596729352485 0.10082287759808 0.53577982544995 0.943443271455699 0.336712279525925 "NF1 MUT" "Gemcitabine_IC_50" 0.0310942663238469 0.326856226549646 1.85553578135301 0.814322518332396 0.980596729352485 0.136574050393093 0.24417784968557 0.875707386589409 1.01723476685266 "BRCA2 MUT" "Erlotinib_IC_50" 0.791434102678425 0.94790644179192 0.322710472727275 0.814331179061214 0.980596729352485 -0.261042666910971 0.615807326993142 0.950136357023296 0.607300786226436 "NF1 MUT" "BIRB.0796_IC_50" 0.943069945286835 0.990147156460271 0.0185149499654939 0.814405276865191 0.980596729352485 -0.0586598126717386 0.919523068520432 0.993794649720217 0.0280984590659363 "BCR_ABL MUT" "AZD6244_IC_50" 0.00530949265326525 0.124415842357912 -3.12306447412003 0.814643139573613 0.980596729352485 -0.294541926505405 0.051789226141414 0.690213288728522 -2.01380461987887 "SETD2 MUT" "Vinorelbine_IC_50" 0.400604572774194 0.806019304668694 1.20518376724141 0.81479512681237 0.980596729352485 -0.249329372968951 0.463369104008867 0.929276781658587 1.03412984786411 "MYCL1 MUT" "SB590885_IC_50" 0.501837916307997 0.846422209719112 0.465198479404029 0.814938314653282 0.980596729352485 0.135376177486114 0.363742550915475 0.91230607860569 0.605359793581426 "CDKN2a(p14) MUT" "CCT007093_IC_50" 0.711089920347326 0.919312211985394 0.0360946772763813 0.814968121902864 0.980596729352485 -0.0235690257184961 0.854294436701879 0.984631915507353 -0.020181482322526 "PDGFRA MUT" "CI.1040_IC_50" 0.573219286069545 0.872620551543038 0.452577752399236 0.815030745962325 0.980596729352485 0.168388554918243 0.554903168618935 0.948071221654821 0.424553716207476 "MSH6 MUT" "FH535_IC_50" 0.954899689595347 0.992679871625456 0.0320122706502639 0.81503318190094 0.980596729352485 0.11330553750002 0.969919920668163 0.997173634484198 0.0203082350014331 "MLLT3 MUT" "BMS.536924_IC_50" 0.871975598662933 0.970405187398056 0.128138167247387 0.8152422502545 0.980596729352485 0.137338032861948 0.830483809563972 0.981482581683432 0.170241550261975 "NF1 MUT" "Docetaxel_IC_50" 0.678951875409809 0.908863195629266 0.162966580503832 0.815262002394254 0.980596729352485 0.0693962442674152 0.970208966950342 0.997173634484198 -0.0150580280212787 "EP300 MUT" "MG.132_IC_50" 0.53051371283731 0.856734402332693 -1.05183425675675 0.81526286525149 0.980596729352485 0.346512290430866 0.923210667439684 0.993931766508607 -0.150386174950689 "NOTCH1 MUT" "RDEA119_IC_50" 0.273015884299749 0.734000646544246 0.694514187481894 0.815347425595454 0.980596729352485 -0.139936215479849 0.658229473170407 0.958313128388245 -0.261291368980998 "PDGFRA MUT" "IPA.3_IC_50" 0.950069527410143 0.991645118533501 -0.0580590104895107 0.815484069504673 0.980596729352485 0.181677640802789 0.727711886859855 0.965402608571648 -0.304927807997099 "BRCA2 MUT" "IPA.3_IC_50" 0.762908808099953 0.936244886169491 0.255538008172798 0.815492909771567 0.980596729352485 0.166928677863337 0.531572098113229 0.94320946427311 -0.497271871896141 "NRAS MUT" "SB590885_IC_50" 0.00791188648054949 0.156679237330372 -0.880323254310346 0.81573302028587 0.980596729352485 0.0673771608979188 0.143480250687934 0.831473272394224 -0.488774323321735 "SMO MUT" "Tipifarnib_IC_50" 0.295164083849781 0.747036827777118 -1.65927597217392 0.815856702725533 0.980596729352485 -0.24448285063358 0.22420397135606 0.86643108387559 -1.8871648029926 "MSH6 MUT" "NVP.TAE684_IC_50" 0.605625047782283 0.882603260686518 0.637937209459464 0.816078790758978 0.980596729352485 0.235714664449484 0.761903679424718 0.969901216545994 0.373104580917621 "NF1 MUT" "CHIR.99021_IC_50" 0.846452014481834 0.961788682268829 0.0603876672077916 0.816209688042571 0.980596729352485 -0.0689878195102848 0.856614268527846 0.984673999326404 -0.0588359369952254 "HRAS MUT" "SB590885_IC_50" 0.856498986374457 0.96514911547635 0.147935896130348 0.816243093733368 0.980596729352485 -0.159781478375947 0.922843481088811 0.993931766508607 -0.069168410783624 "RUNX1 MUT" "QS11_IC_50" 0.751415896485504 0.932940664991998 0.279028624125877 0.816379598280717 0.980596729352485 -0.149865134918622 0.560869743754538 0.949294892873838 -0.555359852543671 "GNAS MUT" "ZM.447439_IC_50" 0.251252779682205 0.717470497840808 0.652990264822129 0.816402707189379 0.980596729352485 -0.104959925291858 0.620040436623374 0.950496524771391 0.266283004212779 "PIK3CA MUT" "CGP.082996_IC_50" 0.771095791006251 0.939898671414565 -0.1349811171514 0.816440620530747 0.980596729352485 -0.0907408854149535 0.569972485834166 0.949294892873838 -0.285638919965445 "CCND1 MUT" "QS11_IC_50" 0.248930024130281 0.715488629021978 0.445450561010099 0.816563658445771 0.980596729352485 0.0664493240157162 0.89164553813823 0.988301482344111 0.0551177484080089 "CDK6 MUT" "MK.2206_IC_50" 0.898891436357143 0.978795346528664 0.0763284979079489 0.816736241345439 0.980596729352485 -0.111148163064191 0.798175486000101 0.976360691959787 -0.149680785713112 "EZH2 MUT" "Etoposide_IC_50" 0.94096211050727 0.989446598697723 0.0689763905590072 0.816771848529499 0.980596729352485 -0.140233266121394 0.927902368209203 0.994186152404781 -0.0859775468877179 "PIK3R1 MUT" "Temsirolimus_IC_50" 0.66090177719966 0.902400992643984 0.356382298944334 0.816936005214827 0.980596729352485 -0.143704681027973 0.95889699526469 0.99641548698706 0.0396049232727227 "MAP2K4 MUT" "Epothilone.B_IC_50" 0.818733117656958 0.95524539465489 -0.150064009001635 0.817182485888688 0.980596729352485 -0.0863529879795996 0.935656330080952 0.994729228933513 -0.0567003469527362 "PIK3R1 MUT" "AS601245_IC_50" 0.247523464424618 0.714668105985286 0.741205673110723 0.817196961976896 0.980596729352485 0.118593039946164 0.250517354497482 0.875707386589409 0.725052207864151 "MSH2 MUT" "Etoposide_IC_50" 0.184428503537335 0.660385845878234 -1.15642137020906 0.817220911985521 0.980596729352485 -0.13182282949273 0.258753373749719 0.877052916121269 -0.939915425434148 "JAK2 MUT" "WO2009093972_IC_50" 0.67280810564284 0.907810511427236 0.248027283383283 0.817238889298228 0.980596729352485 0.122636382104128 0.930259309887222 0.99422596912377 -0.0553073380897242 "MSH2 MUT" "CCT007093_IC_50" 0.897875221395833 0.978288534071451 0.0652237668161443 0.817344266112888 0.980596729352485 0.117857423091322 0.946230030000272 0.995668765770473 -0.0347103363478047 "MLH1 MUT" "A.770041_IC_50" 0.105787478591045 0.549414384425186 1.47916011418686 0.81743964024661 0.980596729352485 0.174062977485251 0.11139959004722 0.797376436030023 1.40279141441292 "FBXW7 MUT" "PF.562271_IC_50" 0.990818263077259 0.998036562927507 0.00383881314935026 0.817593636785889 0.980596729352485 0.0629979672398775 0.992608492628499 0.999469155159075 -0.00315463254069533 "RB1 MUT" "NSC.87877_IC_50" 0.810273632455736 0.952739326074327 0.0344603695228415 0.817603633662221 0.980596729352485 -0.033352588936769 0.930474305640876 0.99422596912377 0.0144992246071543 "AKT2 MUT" "BX.795_IC_50" 0.54382895982051 0.862633715268747 0.435815079429739 0.817624004149887 0.980596729352485 0.127451027495671 0.874905875824072 0.98777404048288 0.1005458631838 "MS-HL MUT" "Cisplatin_IC_50" 0.490877881148198 0.842901481530771 -0.153309981981059 0.817863265366643 0.980751236797348 -0.0448022477373168 0.472155715721581 0.929276781658587 -0.167546883831201 "GNAS MUT" "Etoposide_IC_50" 0.208167547330624 0.681549356120119 0.982645143356643 0.818073827408702 0.980871292185322 0.11679503559442 0.470703862640259 0.929276781658587 0.537810248048378 "MS-HL MUT" "PF.562271_IC_50" 0.376344070364917 0.795051761241315 -0.172961749720983 0.818205741155811 0.980897028510362 0.036864044482865 0.172342054253265 0.842832361237713 -0.29125881677053 "ALK MUT" "QS11_IC_50" 0.878628442621059 0.971802715567801 -0.212134603478262 0.81837011570985 0.980961667919986 -0.234660716075457 0.835017974953776 0.981626636221501 -0.39780312692603 "PIK3R1 MUT" "AKT.inhibitor.VIII_IC_50" 0.342644037562043 0.779440739135111 0.577627782111814 0.819000488312163 0.981328434140868 0.11943004260292 0.308835478984178 0.89718581932126 0.602823063026452 "EZH2 MUT" "PHA.665752_IC_50" 0.853110014650458 0.96439225252237 0.127715641891893 0.819165680574484 0.981328434140868 -0.157211463461866 0.70375293388719 0.962139809888331 -0.30799005020974 "KDR MUT" "Cytarabine_IC_50" 0.589847488262157 0.876506729771444 -0.619148505703425 0.819182914686242 0.981328434140868 0.198968047338888 0.814533104273349 0.977383317127464 -0.252087051260015 "EGFR MUT" "Tipifarnib_IC_50" 0.684475846938905 0.910792758273807 0.193575421754826 0.819285547603131 0.981328434140868 0.0727365576373806 0.536196408751691 0.943443271455699 0.304910827339783 "KDM5C MUT" "EHT.1864_IC_50" 0.787031321642814 0.946449577332088 0.197946085011184 0.819320568579911 0.981328434140868 0.166831571544867 0.793114485762632 0.975393509832241 0.186176884728383 "SMARCB1 MUT" "AUY922_IC_50" 0.438670532595534 0.824054351147029 -1.03847084695653 0.819432643027485 0.981328434140868 -0.205076081235557 0.622850947633107 0.950496524771391 -0.63810723305283 "PIK3R1 MUT" "AZD.0530_IC_50" 0.597179831415176 0.879232253518807 0.481800751700684 0.819449574100741 0.981328434140868 -0.179367486714275 0.55024943142864 0.947060194029534 0.508173684379271 "MYCL1 MUT" "ABT.263_IC_50" 0.869739517194976 0.969505966359972 -0.135773731473652 0.819724749379918 0.981525616724154 -0.169388589197168 0.60680401763798 0.949657634568742 0.406767836403305 "CCND3 MUT" "CHIR.99021_IC_50" 0.989111806053184 0.998036562927507 -0.00982391003460197 0.819909111069459 0.981614022028561 0.155515037608295 0.516145165240978 0.939635632721979 0.451349113414983 "KIT MUT" "CHIR.99021_IC_50" 0.656310996513611 0.901751651084414 -0.286754922010396 0.820167964418217 0.981783961494625 0.139376974193376 0.900290701507712 0.988704788932507 0.0780609292645185 "EP300 MUT" "Bosutinib_IC_50" 0.729934294436744 0.927541495579058 -0.359213248727746 0.820318604432793 0.981783961494625 -0.194699403833436 0.584678849535897 0.949294892873838 -0.523194791124225 "GNAS MUT" "Pyrimethamine_IC_50" 0.599423249080023 0.880481543941089 0.614581672354952 0.820466194592647 0.981783961494625 0.224104662488554 0.627589873478336 0.952105511848497 0.585891525263253 "CCND2 MUT" "Vinorelbine_IC_50" 0.697307902679717 0.914740248699936 0.455857020725387 0.820549257731719 0.981783961494625 0.194134780961636 0.394398388348633 0.915926348152589 1.19818414059996 "MSH6 MUT" "Bleomycin_IC_50" 0.507570370948232 0.847796212975596 -0.777963635764504 0.82060379981698 0.981783961494625 -0.217273002366613 0.566859322870263 0.949294892873838 -0.643845504244764 "EWS_FLI1 MUT" "Bosutinib_IC_50" 0.190582213953471 0.665314717814769 -0.636695405736572 0.820895878941739 0.982001118114438 -0.0988533716738337 0.510280972194653 0.938422873866617 0.342463773613645 "JAK2 MUT" "ZM.447439_IC_50" 0.47983531462404 0.836304203722611 0.46362310170603 0.821222288551042 0.982259278736944 -0.117886905234781 0.897473196127937 0.988400230011434 -0.0881723052142802 "STK11 MUT" "Elesclomol_IC_50" 0.479903407977907 0.836304203722611 0.335040372781063 0.821578274205231 0.98245610826539 0.0885024790542448 0.40003447075329 0.916480913435499 0.402829300059354 "SMARCA4 MUT" "AP.24534_IC_50" 0.598865924898613 0.87982270951606 0.464384608391608 0.821608097746543 0.98245610826539 0.178937956866286 0.501649444224218 0.934042323734638 0.637653890667407 "ERBB2 MUT" "Erlotinib_IC_50" 0.973848868348519 0.995482481561142 -0.0283920604395607 0.82191650956401 0.982568026159928 0.176803261854532 0.519672917522201 0.939635632721979 0.565855673961538 "VHL MUT" "AICAR_IC_50" 0.844837022374018 0.960814136983436 0.119592416829745 0.821922966596341 0.982568026159928 -0.123715586616511 0.977128635552152 0.99742775226181 -0.0182389816224313 "EP300 MUT" "Mitomycin.C_IC_50" 0.63892495069541 0.895624997957207 -0.601809272357717 0.822579218136772 0.982696947307561 0.22601088291005 0.421187637992505 0.922428741067589 -0.997361957067859 "MSH6 MUT" "TW.37_IC_50" 0.861359065833095 0.966384100200122 0.118359905405407 0.822607609280403 0.982696947307561 0.137335220901463 0.88838017801964 0.988301482344111 -0.0909727873937935 "IDH1 MUT" "Bryostatin.1_IC_50" 0.755946789194444 0.934654823707749 -0.277532224347828 0.822741907963686 0.982696947307561 -0.18756351687146 0.974543411052724 0.99742775226181 -0.0273906211970279 "BRAF MUT" "GNF.2_IC_50" 0.378690618247407 0.795952477739693 -0.249710689696971 0.822748512110426 0.982696947307561 0.0661140096420995 0.465332355641654 0.929276781658587 -0.271548413608763 "NRAS MUT" "BI.2536_IC_50" 0.49496664471355 0.843282996121548 -0.342806465454544 0.822765038450311 0.982696947307561 -0.0699787588479965 0.662300769642916 0.958689538788368 -0.254727019409093 "STK11 MUT" "AS601245_IC_50" 0.612282922401747 0.88496040166963 0.190337648583485 0.822802786109744 0.982696947307561 0.0674017821557711 0.292113214624673 0.891803870430294 0.416028080425895 "FGFR3 MUT" "QS11_IC_50" 0.425183767259975 0.819381892124907 -0.905054959930306 0.822805371036935 0.982696947307561 -0.186771464275401 0.374366514796367 0.913948248824328 -0.981036913952306 "KDM5C MUT" "BX.795_IC_50" 0.442659190834686 0.825539266593482 -0.710036124408367 0.823063907297065 0.982698459628458 -0.159365719500368 0.286567381292493 0.888460548829126 -0.862307865466944 "MLH1 MUT" "A.443654_IC_50" 0.0926398447426278 0.521047790474527 1.21947049999999 0.823130572094995 0.982698459628458 0.106435563071065 0.10914289396315 0.795811199742802 1.20430753985545 "PIK3R1 MUT" "WO2009093972_IC_50" 0.730193503568945 0.927599557315949 0.23911303016241 0.823138592633273 0.982698459628458 -0.138919836470389 0.997689341024329 0.99968575015939 0.0019786356530435 "CDK4 MUT" "GNF.2_IC_50" 0.627896309645791 0.891797894691435 -0.43107405782313 0.823475279469082 0.982798821402273 0.190285841218929 0.987505181152267 0.998124818853736 -0.0142425820035 "SMARCA4 MUT" "Camptothecin_IC_50" 0.992091516992482 0.998386941916174 -0.00711097687861247 0.823535482767651 0.982798821402273 -0.10061715722007 0.98773031840698 0.998132070308167 -0.0111066564602835 "PTEN MUT" "EHT.1864_IC_50" 0.697570900523477 0.9148149981614 -0.0672205354173595 0.824097432305298 0.982798821402273 -0.0393229290616774 0.377486210457006 0.914419412871569 -0.162217369682159 "CTNNB1 MUT" "PD.173074_IC_50" 0.563926636644504 0.871754997395969 0.242771181938912 0.824125689063459 0.982798821402273 0.0803174361108728 0.521042598184255 0.939635632721979 -0.272317826830046 "NRAS MUT" "GDC0941_IC_50" 0.940225990307628 0.989446598697723 -0.026075559895052 0.824192300481629 0.982798821402273 -0.0642798705834007 0.338682950050862 0.90661482665324 -0.382081990396167 "EGFR MUT" "Temsirolimus_IC_50" 0.986224108651076 0.996887811168928 -0.00839547430830014 0.824282572952636 0.982798821402273 -0.0827943045985461 0.505443481707018 0.93586286551405 -0.321921778483278 "MYCL1 MUT" "Z.LLNle.CHO_IC_50" 0.343995088765774 0.780249349533262 0.708064895402304 0.824342302351939 0.982798821402273 -0.155221644570462 0.381178430586866 0.915134825237766 -0.665050898047599 "CDKN2C MUT" "Axitinib_IC_50" 0.954229411032891 0.992679871625456 0.0363642072936659 0.824474866215221 0.982798821402273 -0.119029027821287 0.328239180600781 0.902810042912437 0.582375944964501 "CCND3 MUT" "JNK.Inhibitor.VIII_IC_50" 0.818084975669716 0.955165737441734 0.186169790476195 0.824616326105109 0.982798821402273 -0.17100440869088 0.872849440450517 0.987739302532152 0.129820617843294 "CDH1 MUT" "Pazopanib_IC_50" 0.15247580178609 0.625830613280407 0.904969928990618 0.82469946269305 0.982798821402273 0.121196858395316 0.570006335890176 0.949294892873838 0.351620206444511 "CDKN2a(p14) MUT" "BI.2536_IC_50" 0.0467844855892226 0.38471575603508 -0.556100048969069 0.824855609109025 0.982798821402273 -0.0395714559240743 0.21427685848735 0.859434499119166 -0.410216016045101 "PIK3R1 MUT" "LFM.A13_IC_50" 0.892629960230231 0.975972789421281 0.0531486159929702 0.824874573707615 0.982798821402273 -0.081975491186234 0.940858132996859 0.995134500581766 0.0289655069936592 "GNAS MUT" "CEP.701_IC_50" 0.22261094340427 0.695639615894905 0.801757273032624 0.825004106947261 0.982798821402273 -0.106499994985377 0.942302260954127 0.995314665488626 0.043127884849158 "APC MUT" "CGP.60474_IC_50" 0.68843279158396 0.911852590910835 -0.229147058373203 0.825046704464469 0.982798821402273 -0.0965860620335028 0.896903654796944 0.988301482344111 -0.0854950981386268 "FLT3 MUT" "BMS.536924_IC_50" 0.453267932997863 0.828509891052426 -1.07524329251702 0.825097618434165 0.982798821402273 0.237497358925179 0.536173671965983 0.943443271455699 -0.846363127576828 "RUNX1 MUT" "Tipifarnib_IC_50" 0.365466658901414 0.787984332414431 0.909694586363645 0.825149550621226 0.982798821402273 0.147231718679156 0.885663724837341 0.988301482344111 -0.158073511806084 "HRAS MUT" "PF.562271_IC_50" 0.931550201048892 0.986689293492114 -0.0592106152512995 0.825368094422584 0.982798821402273 -0.124656080453159 0.713992012400181 0.962630898212352 0.248244861147008 "MSH2 MUT" "Nilotinib_IC_50" 0.528363062724103 0.855147571292734 -0.392993138752051 0.825437291439158 0.982798821402273 0.111250385246849 0.901734834732166 0.988746233284632 0.0697146730594119 "CCND3 MUT" "SB590885_IC_50" 0.458581485308874 0.828966839128293 0.955557661943328 0.825623525082725 0.982798821402273 -0.237673988993623 0.496429903840489 0.933676180352967 0.762988481813269 "MLL_AFF1 MUT" "Bicalutamide_IC_50" 0.321061978810356 0.762015213745527 0.435826747826092 0.825640142885604 0.982798821402273 0.0936828982638513 0.893063004186403 0.988301482344111 0.0557127735156514 "PTEN MUT" "TW.37_IC_50" 0.485259980560101 0.839913055418877 -0.129691894183927 0.825947410979694 0.982798821402273 0.0380306769550404 0.943405379354066 0.995314665488626 -0.0138256175076634 "PDGFRA MUT" "CCT018159_IC_50" 0.838489139237379 0.959212868273494 -0.129680689655172 0.825999666698648 0.982798821402273 -0.130628878979835 0.741262830506596 0.96672489654949 -0.215055657626058 "MYC MUT" "AZD8055_IC_50" 0.416857548143802 0.814099702076568 0.189816022109207 0.826124475276828 0.982798821402273 0.0402957603122267 0.223208158496323 0.866394954373185 0.28814332413502 "MAP2K4 MUT" "Roscovitine_IC_50" 0.742272480687946 0.929570057037101 0.276878125 0.82613498261204 0.982798821402273 0.164614895535491 0.358815135461997 0.91161229252998 0.899776828055677 "CCND1 MUT" "AP.24534_IC_50" 0.120843792936276 0.580044291137328 0.845309549549556 0.826249762809701 0.982798821402273 0.108801541802381 0.597319987318312 0.949294892873838 0.290528425848813 "FGFR2 MUT" "GW843682X_IC_50" 0.107104889439685 0.551794991672845 2.27531079931973 0.826314431685224 0.982798821402273 -0.16445133919626 0.41505808368645 0.92211126027385 1.4573056025864 "APC MUT" "CEP.701_IC_50" 0.000938701106016876 0.0436471440970465 1.12497900123073 0.826320866136031 0.982798821402273 -0.0579353805960872 0.575813675152775 0.949294892873838 0.213122212705063 "BRCA1 MUT" "Doxorubicin_IC_50" 0.217987925257996 0.690917474738139 1.20451110296686 0.826321225020918 0.982798821402273 0.133980194512866 0.271946120600599 0.880932806352548 1.0301632703424 "MDM2 MUT" "GW.441756_IC_50" 0.655288286010134 0.901148229801177 -0.173351701156069 0.826991654532003 0.983261622390134 -0.0832434936238337 0.618168138097843 0.950394619652337 -0.190904841100191 "MSH2 MUT" "Salubrinal_IC_50" 0.752026397934524 0.933437657590008 -0.224144117647061 0.827043414967266 0.983261622390134 -0.128188749919164 0.912010797615497 0.990530499403599 0.0795168409693835 "NRAS MUT" "EHT.1864_IC_50" 0.364411900189786 0.787388571741174 0.227612844759654 0.827094921701031 0.983261622390134 0.0566121894418373 0.11429095074909 0.799692247086917 0.447143326045146 "MAP2K4 MUT" "FTI.277_IC_50" 0.425975250077772 0.819381892124907 -0.245999224280112 0.827153201314795 0.983261622390134 -0.0614425673527402 0.909786160878439 0.99003063847799 0.0365415350735715 "KDM6A MUT" "Methotrexate_IC_50" 0.206254361881132 0.679262390469222 -0.733504474485592 0.827502445239919 0.983491186329996 -0.0972251409575361 0.498214526988783 0.934042323734638 -0.323153619096141 "IDH1 MUT" "Vorinostat_IC_50" 0.66646724909253 0.905168319191124 -0.386499090551179 0.827567800410321 0.983491186329996 0.148199056975486 0.707994537041302 0.962630898212352 -0.308307568516348 "FGFR2 MUT" "BAY.61.3606_IC_50" 0.00698083626949642 0.145995124935243 2.579360434555 0.827818961651847 0.983557872503179 0.146992866644956 0.131208302773364 0.824721122422311 1.5654028011488 "BCR_ABL MUT" "NVP.BEZ235_IC_50" 0.275957033826892 0.735108059249974 -0.843450662674646 0.827845411210592 0.983557872503179 0.148388392368615 0.893189122955254 0.988301482344111 -0.102037290206959 "PIK3R1 MUT" "Midostaurin_IC_50" 0.407475473366898 0.809352267869285 0.588382995527962 0.828056338610578 0.983676312069839 -0.118802698900132 0.497407573084437 0.934042323734638 0.436592427519526 "MYCL1 MUT" "MG.132_IC_50" 0.486683180219019 0.84074437879216 0.678019771689497 0.828166623730006 0.983676312069839 -0.189563308136963 0.664808115787016 0.959206771190239 -0.408487445265813 "MYC MUT" "PD.0325901_IC_50" 0.775868229715582 0.941591338606299 0.105376161134903 0.828546719899918 0.983995216174788 -0.0756680800369945 0.42398797870559 0.922428741067589 -0.270910919348489 "BRCA2 MUT" "GDC.0449_IC_50" 0.698624526926231 0.914968665673257 0.212591980582528 0.828879784976276 0.983995216174788 -0.106469563341937 0.912683933500523 0.99082410867764 0.0602534355192314 "MAP2K4 MUT" "JW.7.52.1_IC_50" 0.49495721664277 0.843282996121548 1.06492676870748 0.828885515896593 0.983995216174788 0.20454691897334 0.279875990399961 0.88601917827756 2.08381824871525 "NF2 MUT" "PLX4720_IC_50" 0.58985424689093 0.876506729771444 0.221917091632028 0.828890614815418 0.983995216174788 0.0796582535748172 0.645746869829811 0.957070872538585 0.183245807235106 "MLL_AFF1 MUT" "CI.1040_IC_50" 0.462136798094255 0.82931728663973 -0.93132547900764 0.829010994649853 0.983995216174788 -0.248573119614583 0.991101777530872 0.99917869279774 -0.0126017769352539 "MSH6 MUT" "JNK.9L_IC_50" 0.854499341070456 0.964632429914253 -0.0896684895470384 0.829099898956867 0.983995216174788 -0.0824644068592493 0.880787276555838 0.988301482344111 -0.0722840134171676 "MYCL1 MUT" "SB.216763_IC_50" 0.740053188660361 0.929570057037101 0.183739642857144 0.829284387828364 0.984082662787774 0.114870807759398 0.184280988635551 0.851001889249827 0.780109427080751 "CDKN2a(p14) MUT" "JNK.9L_IC_50" 0.0722057251050057 0.474889173046706 -0.213062258745205 0.829900394360049 0.984255298070832 0.0208278305711177 0.986901265980039 0.998124818853736 -0.00216070657062791 "ERBB2 MUT" "AS601245_IC_50" 0.552710100438333 0.866603215811789 0.263253877310924 0.830085233379804 0.984255298070832 0.0781334955186726 0.586097571392202 0.949294892873838 0.253108348119068 "NRAS MUT" "Parthenolide_IC_50" 0.554164726928777 0.866925654369292 -0.208846787003608 0.830299006063551 0.984255298070832 0.0728205067297392 0.393385270444621 0.915926348152589 -0.348621211268911 "HRAS MUT" "Midostaurin_IC_50" 0.681602792620438 0.909861476478352 -0.344297083188904 0.830487291510193 0.984255298070832 -0.13917723367455 0.591122579548353 0.949294892873838 0.410171983344794 "APC MUT" "MK.2206_IC_50" 0.00562262252431307 0.129130765471956 0.975120788566831 0.830514097159065 0.984255298070832 -0.0639781980158299 0.0366458703763239 0.638141127082613 0.886708459592045 "MLH1 MUT" "JNK.9L_IC_50" 0.621345001906062 0.888247588669681 -0.1978784 0.830871448390488 0.984255298070832 0.0676864042154611 0.915958870850955 0.992270155163129 -0.042213312398227 "PIK3CA MUT" "AS601245_IC_50" 0.306821699400671 0.755024525457845 -0.26300201140146 0.830929371595102 0.984255298070832 -0.0442886304781384 0.484069972942896 0.932745808137526 -0.195440250850759 "EWS_FLI1 MUT" "VX.680_IC_50" 0.926006920425986 0.98643792569589 -0.0750276494417853 0.831046233245468 0.984255298070832 -0.122096152525858 0.749434273331036 0.968780465757047 0.306898651383529 "PIK3CA MUT" "ATRA_IC_50" 0.11283250969067 0.563938179281427 0.399092984420639 0.831083122132935 0.984255298070832 0.042874790757531 0.393425451826786 0.915926348152589 0.207325668653981 "RUNX1 MUT" "Pazopanib_IC_50" 0.558286872353042 0.869087767461413 0.495360162587417 0.831462898325455 0.984255298070832 -0.152675844234908 0.964291780923704 0.997126446878798 -0.0384442339047856 "NF2 MUT" "CCT018159_IC_50" 0.979504464432989 0.996276778834563 0.00812652574156128 0.831751595845896 0.984255298070832 0.0632202926850353 0.660188713014767 0.958655323787467 0.149288069550789 "IDH1 MUT" "Cytarabine_IC_50" 0.268354873729258 0.731654786713776 -1.55486577609107 0.831905233760644 0.984255298070832 -0.225098754406605 0.464639553476608 0.929276781658587 -0.95729688990201 "CDKN2a(p14) MUT" "KU.55933_IC_50" 0.814851679196921 0.954309977735381 -0.0267978703250044 0.832127656023068 0.984255298070832 0.0223675047530958 0.631918892206443 0.952523560833852 0.0602832645208555 "MYCL1 MUT" "Epothilone.B_IC_50" 0.963492843513198 0.994159243759316 0.0340822786596125 0.83220774770158 0.984255298070832 0.0899777052640956 0.712632427610771 0.962630898212352 -0.292199777968815 "BCR_ABL MUT" "VX.702_IC_50" 0.000208747098251625 0.0159817498239025 -2.77088817049803 0.832296425629959 0.984255298070832 0.16597934512401 0.0304396011183297 0.604774267409141 -1.55817141041515 "MSH2 MUT" "GSK269962A_IC_50" 0.738819635930225 0.929570057037101 0.317878522336772 0.83235084337554 0.984255298070832 0.189175377669807 0.862511351937796 0.985965158522276 0.167754757823985 "PDGFRA MUT" "Vinblastine_IC_50" 0.568969760132398 0.872389778906173 -0.457155061068703 0.832426867296309 0.984255298070832 -0.122899346541753 0.780013675162852 0.972337708041191 -0.213620518500542 "ALK MUT" "Bortezomib_IC_50" 0.754284955482772 0.933900277236682 0.408937559726962 0.832467383527357 0.984255298070832 0.225184636571718 0.781120808805267 0.973017078278378 -0.423991443754629 "CDK4 MUT" "Pazopanib_IC_50" 0.823972968694609 0.957177484110155 -0.149218777680142 0.832513931586725 0.984255298070832 0.121301794748304 0.738881087434344 0.96672489654949 0.216758285587505 "CDK4 MUT" "NVP.TAE684_IC_50" 0.620222669683774 0.887671478437871 -0.862951630872479 0.832635424578786 0.984255298070832 0.303465095967922 0.894719668438098 0.988301482344111 -0.232441432064285 "CDKN2C MUT" "PF.4708671_IC_50" 0.592358669613225 0.877813673424837 -0.258532088989441 0.832728779609602 0.984255298070832 -0.101954312501221 0.535423581775629 0.943443271455699 -0.334825305886985 "NF2 MUT" "GDC0941_IC_50" 0.795381614830559 0.948769890110348 -0.105059828144079 0.832803509461063 0.984255298070832 0.0695086395912001 0.49495851239155 0.933639405738697 0.293119708893948 "BRCA1 MUT" "OSI.906_IC_50" 0.525689402479323 0.854969048950887 -0.648892479930204 0.832992095552199 0.984255298070832 -0.20570931745189 0.41101538751725 0.921714070263062 -0.850485628897634 "EP300 MUT" "BMS.509744_IC_50" 0.693050795863517 0.913066921534475 -0.485060779661013 0.833132224443333 0.984255298070832 0.191905536104133 0.8791214817668 0.988115784617527 -0.183702795964516 "JAK2 MUT" "BMS.509744_IC_50" 0.489671972523578 0.842622900209628 0.6941505782313 0.83313350635953 0.984255298070832 0.156542110281988 0.286214329911719 0.88845489826843 1.29881250379948 "FAM123B MUT" "AS601245_IC_50" 0.759341495516116 0.9351978673802 0.247856797202801 0.833276160047335 0.984255298070832 0.13634675499305 0.507842164240576 0.937465445982239 0.536895868378668 "PDGFRA MUT" "Bexarotene_IC_50" 0.45773275955882 0.828966839128293 -0.535613201048952 0.833551526457496 0.984255298070832 -0.135062234980057 0.695867255259424 0.961100601384891 0.273803165609728 "RUNX1 MUT" "AG.014699_IC_50" 0.341461512713414 0.778707276763076 -0.792044679400759 0.833577632992856 0.984255298070832 -0.153590369289733 0.365764609588391 0.913948248824328 -0.690893031266842 "CDK6 MUT" "AZD.0530_IC_50" 0.491635046267738 0.842990705166559 0.806569890765772 0.833752743131019 0.984255298070832 0.214105147465365 0.211771665738832 0.855272470862467 1.68531421837007 "STK11 MUT" "BMS.536924_IC_50" 0.586441409967454 0.876506729771444 -0.60633592465753 0.833899457497619 0.984255298070832 -0.173139603317258 0.488700193535121 0.933639405738697 -0.833724548074902 "MLL_AFF1 MUT" "Nutlin.3a_IC_50" 0.340207853227717 0.778500909061878 -1.26028721484373 0.833930051663859 0.984255298070832 -0.258248657876755 0.870450010965892 0.98753907730331 0.211266965789813 "FGFR3 MUT" "Camptothecin_IC_50" 0.818861650499636 0.95524539465489 -0.36456487096774 0.834043993149337 0.984255298070832 -0.210864756938806 0.623630316141304 0.950496524771391 -0.687293031913894 "CDKN2a(p14) MUT" "OSI.906_IC_50" 0.377429123421262 0.795261485512158 -0.15610184679462 0.834191619199761 0.984255298070832 -0.0365690425557741 0.222577264817016 0.865601665610206 -0.241696810864831 "BRCA2 MUT" "PD.0325901_IC_50" 0.43027456423528 0.820918238409269 0.889253012922482 0.834302127781684 0.984255298070832 -0.223512485958164 0.194193221133319 0.851001889249827 1.28569285329538 "RUNX1 MUT" "IPA.3_IC_50" 0.644673540005203 0.896610607131532 0.427549031468535 0.834557193910248 0.984255298070832 -0.16221448455199 0.790052159704734 0.975393509832241 -0.254854321292451 "FLT3 MUT" "Bosutinib_IC_50" 0.896663546067568 0.977448011860325 -0.135151085877867 0.834557998218161 0.984255298070832 0.179801570391787 0.453701007215442 0.925809648901546 0.724455229020279 "MYCL1 MUT" "Axitinib_IC_50" 0.731959726137831 0.928176068595523 0.216995877159309 0.834904857199671 0.984255298070832 -0.111307710473723 0.81535332364002 0.977383317127464 -0.14238240931372 "TET2 MUT" "MG.132_IC_50" 0.419240244265653 0.81418600684961 1.107622259887 0.835005532488203 0.984255298070832 -0.255233345638363 0.455602760487679 0.925809648901546 1.16028107042695 "RB1 MUT" "Vorinostat_IC_50" 0.942141536393481 0.989610761053874 0.013115234765235 0.835024080665434 0.984255298070832 0.0294829782284901 0.491883427241005 0.933639405738697 0.125679479489012 "MYCL1 MUT" "Gefitinib_IC_50" 0.976376015233918 0.996276778834563 -0.0171295398272548 0.835025292980182 0.984255298070832 -0.108184401921595 0.592168673099081 0.949294892873838 0.305872769669457 "MS-HL MUT" "Roscovitine_IC_50" 0.87225424694492 0.970405187398056 0.0473105034446204 0.835072797960744 0.984255298070832 0.0550078262474353 0.556352495636203 0.948726289121566 -0.193121883004572 "BRCA2 MUT" "CGP.082996_IC_50" 0.192058759529591 0.668023137615267 1.51179656462585 0.835136522626977 0.984255298070832 0.204234648073407 0.121934321361769 0.809590452621284 1.7949370627202 "FGFR2 MUT" "X681640_IC_50" 0.553717465080919 0.866925654369292 0.684218929006079 0.835137502154703 0.984255298070832 -0.207326860421642 0.375564636291134 0.914419412871569 1.35524776819526 "TET2 MUT" "Erlotinib_IC_50" 0.810221836188291 0.952739326074327 0.239709902676401 0.835291336946192 0.984255298070832 -0.189752692230829 0.502767869147261 0.934042323734638 0.79657734389162 "FBXW7 MUT" "KIN001.135_IC_50" 0.484818992570089 0.83972091053812 0.17455560553633 0.835377108479179 0.984255298070832 0.0515299687817867 0.601752291039982 0.949657634568742 -0.126575974402266 "MLLT3 MUT" "AKT.inhibitor.VIII_IC_50" 0.52017373844094 0.852599738673405 -0.223787153571427 0.835410813482761 0.984255298070832 -0.0617608385805759 0.487106175529702 0.933639405738697 -0.246230988561364 "FAM123B MUT" "CI.1040_IC_50" 0.70557213928453 0.916377035534646 0.339069155172415 0.835763122992643 0.984255298070832 -0.166679101515075 0.869229114720036 0.98753907730331 0.132370039538043 "JAK2 MUT" "Cisplatin_IC_50" 0.560086100593177 0.869754268118204 0.367593563492063 0.835985942326416 0.984255298070832 0.112918128046076 0.356690495366207 0.91161229252998 0.606220245878502 "PIK3CA MUT" "FTI.277_IC_50" 0.429519350427866 0.820918238409269 -0.124342088804715 0.836053412373615 0.984255298070832 -0.0299683978285023 0.561190502948936 0.949294892873838 -0.0952923976965459 "MYCN MUT" "Lenalidomide_IC_50" 0.597375312843566 0.879232253518807 -0.130986527347781 0.836073886733862 0.984255298070832 -0.0463835995123333 0.556830839436459 0.948995333915792 -0.163845346425531 "PIK3CA MUT" "CCT018159_IC_50" 0.623778712026794 0.889924295824892 -0.108095795630104 0.836113274284467 0.984255298070832 -0.042961004971394 0.731052024589421 0.96639568318693 -0.0841892851092151 "GNAS MUT" "Mitomycin.C_IC_50" 0.255855443766421 0.720311238267775 0.802771604761902 0.836142457201924 0.984255298070832 0.114223122482339 0.597792426558554 0.949294892873838 0.365330510567634 "FLT3 MUT" "AS601245_IC_50" 0.615050296736487 0.885815598771911 -0.454461521815018 0.836193636108835 0.984255298070832 0.150971686259995 0.47089873601413 0.929276781658587 -0.648416715680435 "MSH6 MUT" "Epothilone.B_IC_50" 0.394305924076311 0.803222955584382 -0.707698006151146 0.836332774542937 0.984255298070832 -0.0979063168920498 0.348909523186554 0.909999728614578 -0.754409198338088 "TET2 MUT" "Paclitaxel_IC_50" 0.368974423917114 0.789246419666677 -1.35687321768709 0.83691849301981 0.984255298070832 -0.136621004933637 0.299581621446151 0.894167310052 -1.90787079351829 "CDKN2a(p14) MUT" "AZD.2281_IC_50" 0.707533217782002 0.917562549248444 -0.0511371672299497 0.836968243985588 0.984255298070832 0.0219891280245903 0.596497964051904 0.949294892873838 -0.0706475702460311 "ALK MUT" "Temsirolimus_IC_50" 0.163557022403961 0.638931457923803 -2.24894359772295 0.837069476424525 0.984255298070832 -0.255896670069698 0.265264420993571 0.877052916121269 -1.71763826748743 "GNAS MUT" "Cytarabine_IC_50" 0.420792731274877 0.815417902346101 0.568849116602684 0.837246056631625 0.984255298070832 -0.109713861563827 0.891022146055857 0.988301482344111 0.0895381403035375 "SMAD4 MUT" "JNK.Inhibitor.VIII_IC_50" 0.66825094643226 0.906205016836906 0.0984754828803933 0.837363329504778 0.984255298070832 -0.046212775956787 0.776549480886233 0.972337708041191 -0.0699554212229278 "BCR_ABL MUT" "Bicalutamide_IC_50" 0.674762965132705 0.908515750961728 0.130596431064575 0.837528496437692 0.984255298070832 0.0728808768825891 0.575232899057842 0.949294892873838 -0.166636090953055 "PDGFRA MUT" "GDC.0449_IC_50" 0.84772452071844 0.962618339080162 0.10544168932039 0.837661070697475 0.984255298070832 -0.100260478123329 0.74313066795812 0.966920292106991 0.181041795450446 "KDR MUT" "CHIR.99021_IC_50" 0.435032909521015 0.823150425912549 -0.648138981001721 0.837774193544289 0.984255298070832 -0.161002995835182 0.990451070420848 0.998681346929993 -0.00969057241076525 "NRAS MUT" "Shikonin_IC_50" 0.431223961956632 0.820918238409269 -0.257859112698412 0.837837901063761 0.984255298070832 -0.0582104567529141 0.85338921944883 0.984631915507353 -0.0675498983056302 "MLL_AFF1 MUT" "NVP.BEZ235_IC_50" 0.927277689969338 0.986482171132929 0.0997903439363816 0.837896249365206 0.984255298070832 0.164377483205522 0.431256272008199 0.922569292988365 0.827264484088671 "MLL_AFF1 MUT" "CGP.60474_IC_50" 0.358878472864478 0.786601117838604 -1.20997057142858 0.837997929866577 0.984255298070832 -0.204859700579411 0.4057351362719 0.918000323669952 -1.07258961770647 "MS-HL MUT" "AG.014699_IC_50" 0.660112637028498 0.902400992643984 -0.0984183676184292 0.838094892326578 0.984255298070832 0.0405179434279379 0.262279751107691 0.877052916121269 -0.25175681896576 "SMO MUT" "PF.4708671_IC_50" 0.884461904879952 0.974262585935532 0.121003923766815 0.838195295376167 0.984255298070832 0.167208819599948 0.854674391192937 0.984631915507353 0.154094117236011 "PTEN MUT" "Midostaurin_IC_50" 0.882743254166193 0.973927829424842 -0.0320379315221179 0.838211553764981 0.984255298070832 0.0350501853504418 0.472813850977911 0.929276781658587 0.154315664766829 "EGFR MUT" "NSC.87877_IC_50" 0.988785579185769 0.998036562927507 0.00334774053045084 0.838217160714986 0.984255298070832 0.0479430881893075 0.409175066589051 0.920903133902018 0.209395758964058 "BRCA2 MUT" "GW843682X_IC_50" 0.384833560814372 0.798746759187088 1.5026970338983 0.838355947862947 0.984255298070832 0.183164206423924 0.194771887400623 0.851001889249827 2.35308401375822 "MYCN MUT" "NVP.TAE684_IC_50" 0.976908146887128 0.996276778834563 0.0160802345110087 0.838617477985423 0.984255298070832 -0.0969046706977175 0.105964799207453 0.788168661441703 -1.07785460040571 "FGFR3 MUT" "Obatoclax.Mesylate_IC_50" 0.530731180917724 0.856734402332693 -0.835648289198598 0.838617951301721 0.984255298070832 -0.199303479058828 0.406615407673571 0.918634300572115 -1.05796511944293 "HRAS MUT" "NU.7441_IC_50" 0.924640668192584 0.98643792569589 -0.0555777521537446 0.838668142547713 0.984255298070832 -0.10544827750395 0.875078353391201 0.98777404048288 -0.0889398741867993 "FGFR3 MUT" "BIRB.0796_IC_50" 0.733502103665818 0.928593402067957 0.293287333333339 0.838804273846724 0.984255298070832 0.167522808205336 0.734278128619957 0.96672489654949 0.288311484687028 "BRAF MUT" "AS601245_IC_50" 0.196736843700335 0.672783946439227 -0.32942189063044 0.838946522634473 0.984255298070832 0.0439294387007953 0.338063499625797 0.906230588643738 -0.289261264136319 "NOTCH1 MUT" "Shikonin_IC_50" 0.438463466545252 0.824054351147029 -0.401693100265013 0.838984416595287 0.984255298070832 -0.0912512578999393 0.626943642323739 0.952105511848497 0.271018519811856 "CDKN2a(p14) MUT" "NU.7441_IC_50" 0.697169109571916 0.914698512088563 -0.0507592063694267 0.839221127976331 0.984255298070832 0.0240779913053908 0.571473395835187 0.949294892873838 0.07932428279048 "SMAD4 MUT" "XMD8.85_IC_50" 0.437151389685057 0.823808548892323 -0.540910348432053 0.839239136732419 0.984255298070832 -0.126455920318294 0.16101902419031 0.839927262232576 -1.01502705071303 "GNAS MUT" "GNF.2_IC_50" 0.748524235478418 0.932217604162647 -0.233225163822524 0.839441980160207 0.984255298070832 0.140457434668366 0.874843231161515 0.98777404048288 0.117187749026239 "CTNNB1 MUT" "Embelin_IC_50" 0.419513708862709 0.814360928614146 -0.302277167259789 0.839482764633777 0.984255298070832 0.0604580965184625 0.906421514280628 0.988917021334873 -0.0489270750663015 "EZH2 MUT" "Bortezomib_IC_50" 0.192512303227482 0.668037820564704 1.47505104452055 0.839541880293248 0.984255298070832 0.186119663558549 0.57936897500745 0.949294892873838 0.685211088180359 "FLT3 MUT" "DMOG_IC_50" 0.463036453175579 0.829412412394578 -0.658887024221453 0.839650196219466 0.984255298070832 0.165242698246714 0.918060047570545 0.992963223576061 0.0877455641690951 "JAK2 MUT" "BMS.754807_IC_50" 0.617318265653303 0.886326305706232 0.437380012781963 0.839685805264117 0.984255298070832 -0.147783828800974 0.866385909888451 0.987077901072027 0.157119879756356 "HRAS MUT" "Methotrexate_IC_50" 0.199055921086672 0.674012093366938 1.16761980808079 0.839769491243163 0.984255298070832 0.140132562000764 0.52982787435387 0.94315521189351 0.452793221039084 "HRAS MUT" "Bicalutamide_IC_50" 0.703226577901856 0.915500829364901 -0.106143706293706 0.840011511821085 0.984255298070832 0.053766000510144 0.761298373801353 0.969901216545994 0.079377361251171 "MLLT3 MUT" "Bortezomib_IC_50" 0.878225981786397 0.971802715567801 -0.110986625874125 0.84010657279018 0.984255298070832 0.117831646690975 0.90605668583401 0.988917021334873 0.0858874219446745 "BRAF MUT" "GW843682X_IC_50" 0.637453522747613 0.895456450974187 -0.260111887681161 0.840109239087192 0.984255298070832 -0.0618501783731336 0.552612401080343 0.94744222663987 -0.438032429120472 "BCR_ABL MUT" "Z.LLNle.CHO_IC_50" 0.249534645668564 0.71580012538195 -1.05122180479454 0.840186514758541 0.984255298070832 -0.215262114303598 0.737354318713004 0.96672489654949 -0.303804785619988 "MDM2 MUT" "IPA.3_IC_50" 0.190311873261501 0.664991779417723 0.861759269841267 0.840210705309772 0.984255298070832 0.111355565185765 0.371409394190903 0.913948248824328 0.545019783869234 "PDGFRA MUT" "PAC.1_IC_50" 0.961249075965064 0.993899806776065 -0.0376693811188812 0.84030110106575 0.984255298070832 0.130826974435527 0.494340875461479 0.933639405738697 -0.519187869709973 "KIT MUT" "BI.D1870_IC_50" 0.763499758019729 0.936244886169491 -0.24302697131931 0.840303055705013 0.984255298070832 0.140736765925078 0.365922055704794 0.913948248824328 -0.697696826566256 "MET MUT" "Imatinib_IC_50" 0.768972695335733 0.938868331695358 0.289822929292926 0.840469981096844 0.984255298070832 0.194895874125053 0.542689205291872 0.945765861891114 0.63495807702146 "CDKN2A MUT" "X681640_IC_50" 0.17082252447748 0.649721929411943 -0.201513474103849 0.840864788249427 0.984255298070832 -0.0262438780711423 0.361255924352679 0.91161229252998 -0.14207172844914 "SMARCB1 MUT" "Bleomycin_IC_50" 0.520340639132745 0.852599738673405 -1.50154321739131 0.840948833767413 0.984255298070832 -0.381482337664882 0.806749790294524 0.977383317127464 -0.557542743774068 "FGFR2 MUT" "Tipifarnib_IC_50" 0.00126138443022639 0.0516237563356707 3.605746930192 0.840972945883876 0.984255298070832 0.152297047136877 0.033553693715592 0.618827479917328 2.70241707370951 "MAP2K4 MUT" "CGP.082996_IC_50" 0.562955687364015 0.871238675201477 0.548928521046645 0.841010899213077 0.984255298070832 0.16015712184681 0.249133749437919 0.875707386589409 1.31585908990338 "EZH2 MUT" "FTI.277_IC_50" 0.549586663575458 0.864873049004332 0.250692119751558 0.841171876641912 0.984255298070832 0.0761732083513887 0.688394293105382 0.961100601384891 -0.171778323492895 "CDKN2C MUT" "WH.4.023_IC_50" 0.930522086494521 0.986689293492114 -0.127702783908047 0.841173230979745 0.984255298070832 0.255420508082405 0.628184791009281 0.952175822853038 0.804464003313765 "STK11 MUT" "FH535_IC_50" 0.934315818326234 0.987517726433927 -0.0273205834086804 0.841581270386464 0.984255298070832 -0.0568445928018207 0.829489034734823 0.98125900619922 0.072727884810472 "CDKN2a(p14) MUT" "Thapsigargin_IC_50" 0.0264903088749343 0.301229747910745 -0.55303770368194 0.841828646197963 0.984255298070832 0.0398275893852442 0.672301969562584 0.960256725054738 -0.114555316243047 "BCR_ABL MUT" "Parthenolide_IC_50" 0.444359302583916 0.825606373270691 -0.613553203389824 0.842139222539145 0.984255298070832 -0.186615190956798 0.497095952411335 0.934008720636554 -0.570011721785162 "MSH6 MUT" "BMS.754807_IC_50" 0.981356856783347 0.996512714638228 -0.0191531405975389 0.842164294334755 0.984255298070832 0.135800708152012 0.980659198554272 0.997827228172038 0.0193683182003867 "ALK MUT" "Vinblastine_IC_50" 0.301032181820914 0.751119785777076 -1.3083004402277 0.842386589870218 0.984255298070832 -0.182880347185742 0.43051089965966 0.922428741067589 -0.941757897893367 "EP300 MUT" "CGP.082996_IC_50" 0.572783001591872 0.872536164174514 -0.65433948979592 0.842415327674437 0.984255298070832 0.194048971804602 0.764433523690753 0.969901216545994 -0.34398240349713 "MDM2 MUT" "BI.2536_IC_50" 0.473084723765491 0.834286225528459 -0.73362951369863 0.842482110376326 0.984255298070832 -0.120762453938811 0.691257178338837 0.961100601384891 -0.421427064032807 "IDH1 MUT" "TW.37_IC_50" 0.412540186901084 0.812480994891775 -0.783331394618827 0.842529247087572 0.984255298070832 -0.170944479411142 0.590798116491346 0.949294892873838 -0.495903884400989 "AKT2 MUT" "PF.02341066_IC_50" 0.872175711007905 0.970405187398056 -0.185665969798656 0.842753953313314 0.984255298070832 -0.209276435794715 0.814393187625277 0.977383317127464 -0.266701089624315 "MLH1 MUT" "NVP.TAE684_IC_50" 0.290896010987235 0.746581806188469 0.928347308219184 0.842784808868144 0.984255298070832 -0.144741364072237 0.317041291987511 0.900918773778407 0.894924084418632 "NF1 MUT" "AZD6482_IC_50" 0.251819274864332 0.717470497840808 0.489479331655838 0.842853663491185 0.984255298070832 -0.0720475856666274 0.581487395034182 0.949294892873838 0.248904140004358 "MYC MUT" "PD.0332991_IC_50" 0.41192094935674 0.812480994891775 0.266815068791949 0.843098010389319 0.984255298070832 0.051550847942521 0.76830461690956 0.969901216545994 0.0937903904337482 "EGFR MUT" "WO2009093972_IC_50" 0.708295662366455 0.917841100717424 -0.138830631578947 0.84311543375304 0.984255298070832 0.06627713668317 0.755700221745395 0.969901216545994 0.121453125480649 "FLCN MUT" "AZD.0530_IC_50" 0.572392212778546 0.872389778906173 0.662187908783787 0.843137706212332 0.984255298070832 0.200167239694056 0.617418166277024 0.950247055931602 -0.973557098048333 "VHL MUT" "AZD8055_IC_50" 0.687879036713677 0.91179906344092 -0.203225540581162 0.843181193052182 0.984255298070832 0.0788176780754137 0.944230905327226 0.995333788087439 -0.0371468835744348 "FLT3 MUT" "RO.3306_IC_50" 0.835574843456922 0.959122768755193 0.176647566862366 0.843338810163663 0.984255298070832 -0.162269184624453 0.811229716437348 0.977383317127464 0.203991373628938 "TP53 MUT" "MK.2206_IC_50" 0.146516695884136 0.619919550890177 0.249835704835625 0.843581405559114 0.984255298070832 0.0288322860284302 0.0946625966755219 0.770131561879207 0.302464400357837 "CCND3 MUT" "BAY.61.3606_IC_50" 0.692990350500758 0.913066921534475 0.378644169284476 0.843638752387716 0.984255298070832 -0.131827511938967 0.855515553814633 0.984631915507353 0.164116720707257 "KDM6A MUT" "BX.795_IC_50" 0.835036675539458 0.959122768755193 -0.0845442 0.843686406816089 0.984255298070832 0.062089793012764 0.147710002130955 0.831473272394224 -0.534838827044049 "MYC MUT" "Bicalutamide_IC_50" 0.525049338481252 0.854969048950887 0.0624892753244494 0.843754572652674 0.984255298070832 0.0185739337222068 0.592938400838418 0.949294892873838 0.05207680224723 "KDM6A MUT" "NVP.BEZ235_IC_50" 0.62896242228043 0.892017769446263 -0.183945928037608 0.843815393027156 0.984255298070832 0.0546045434081168 0.320189268697087 0.900918773778407 -0.371181035195954 "CCND3 MUT" "X681640_IC_50" 0.634335919521148 0.894070354113207 0.549574912778893 0.843837315922559 0.984255298070832 -0.194503649359269 0.785788298342832 0.974807190013589 0.293247115023021 "CDK4 MUT" "FH535_IC_50" 0.295408227945449 0.747204646998838 -0.591981793497368 0.843840249081711 0.984255298070832 -0.0960207403951674 0.712758634729955 0.962630898212352 -0.211731196609322 "KDM5C MUT" "Lapatinib_IC_50" 0.99778322296755 0.999204573800497 0.00287214532871903 0.844012108537169 0.984255298070832 -0.176126746321902 0.761438423842178 0.969901216545994 0.273486238082806 "PIK3CA MUT" "WZ.1.84_IC_50" 0.817651517604129 0.955165737441734 -0.109574715955423 0.844267774100201 0.984255298070832 0.0779616730284144 0.670116612399 0.95927684711462 -0.210879210032623 "CCND1 MUT" "PHA.665752_IC_50" 0.923514412867218 0.98643792569589 0.0387632986111111 0.844451371846593 0.984255298070832 0.0802388578362563 0.966676310889606 0.997173634484198 0.0200832184946801 "MAP2K4 MUT" "ATRA_IC_50" 0.257672683311494 0.721889937062894 0.569861293774323 0.844461761260758 0.984255298070832 0.0778078784322374 0.896019594485805 0.988301482344111 0.0638937712878237 "HRAS MUT" "Bryostatin.1_IC_50" 0.688282829024399 0.911852590910835 -0.2271546520979 0.844602776169236 0.984255298070832 -0.105113789765396 0.665461007702921 0.959206771190239 0.234089671969523 "ERBB2 MUT" "ABT.888_IC_50" 0.750755806695955 0.932701537476322 0.0827933843137257 0.844612860528228 0.984255298070832 -0.0445722000312997 0.499828488355425 0.934042323734638 -0.175489744343455 "VHL MUT" "MK.2206_IC_50" 0.331799215205497 0.772603259108552 -0.617419505219198 0.84462329305171 0.984255298070832 0.0999801134491194 0.65237752676321 0.958313128388245 -0.30373362762629 "STK11 MUT" "AZD8055_IC_50" 0.502639267721504 0.846565396668817 0.207389434770385 0.844643856649071 0.984255298070832 -0.0472847192241765 0.355021248586161 0.91161229252998 0.297537611651072 "EP300 MUT" "PLX4720_IC_50" 0.688187970563178 0.911852590910835 0.439213865900385 0.844897142836035 0.984255298070832 0.190374689218045 0.874054543426749 0.98777404048288 0.156347363359304 "SMAD4 MUT" "BX.795_IC_50" 0.206418177847001 0.679262390469222 0.406328165630117 0.844899946991725 0.984255298070832 -0.0501620208751603 0.761356172728832 0.969901216545994 -0.0917037673204285 "TSC1 MUT" "Methotrexate_IC_50" 0.249533560764008 0.71580012538195 -1.80631784569139 0.844916410617841 0.984255298070832 0.234185604488183 0.919651992050629 0.993794649720217 0.125375333615836 "MET MUT" "A.770041_IC_50" 0.736199239291909 0.928872455997232 0.611183128813563 0.844946398537335 0.984255298070832 0.287176713895508 0.217677086033076 0.860928912580141 2.12293905111165 "EP300 MUT" "Etoposide_IC_50" 0.395143348512851 0.8037107527999 -1.20516732987907 0.845463780930797 0.984255298070832 -0.180639885084118 0.343670593531085 0.907180409180092 -1.26435094175623 "BCR_ABL MUT" "NVP.TAE684_IC_50" 0.674513734933172 0.908418658675584 -0.518912452702709 0.845690884064957 0.984255298070832 -0.204822762288675 0.90285839803082 0.988746233284632 -0.153948657611759 "CCND3 MUT" "AZD6244_IC_50" 0.89912352025628 0.978928035233054 0.201238420618552 0.845717231781327 0.984255298070832 -0.280315663346889 0.669171498379657 0.959230524020512 0.60288078280559 "NRAS MUT" "KU.55933_IC_50" 0.474416305037705 0.834460661638643 0.159352643962849 0.845895845674159 0.984255298070832 0.0398324596037615 0.36913404133904 0.913948248824328 0.226012925304629 "MET MUT" "Temsirolimus_IC_50" 0.141092015742054 0.612732612129672 0.979108594132822 0.845915363875065 0.984255298070832 -0.0991025560828324 0.654197169475266 0.958313128388245 0.282818942322232 "MSH2 MUT" "AZD.2281_IC_50" 0.446425411653939 0.825892730562573 -0.433789652087478 0.846134928209158 0.984255298070832 0.0835419858950612 0.927084823602047 0.994186152404781 0.0461791558290218 "PDGFRA MUT" "JNK.Inhibitor.VIII_IC_50" 0.814172645767504 0.953913887475092 0.120668122605364 0.846219803853438 0.984255298070832 -0.0952579602245298 0.872240930060377 0.987643979884169 0.084409519560319 "KDM5C MUT" "X17.AAG_IC_50" 0.822512260936465 0.956993500507893 -0.285064125318076 0.846427892230787 0.984255298070832 0.216548775767725 0.633762738910207 0.952523560833852 -0.528084513978779 "MLL_AFF1 MUT" "A.443654_IC_50" 0.561339878828074 0.870331610312871 -0.83556260544218 0.846518247455087 0.984255298070832 0.184299508363643 0.434671247352486 0.922569292988365 -1.15240860263523 "FLCN MUT" "Mitomycin.C_IC_50" 0.21470269058678 0.688117861819268 1.23413546678322 0.846681384253833 0.984255298070832 0.150387410294237 0.487076563864068 0.933639405738697 0.864206044185393 "TET2 MUT" "Nutlin.3a_IC_50" 0.531012860514939 0.856734402332693 -0.676729825179396 0.84671884050759 0.984255298070832 -0.193849958717729 0.148403021092973 0.831473272394224 1.85668109337334 "SMARCA4 MUT" "VX.702_IC_50" 0.244335685348905 0.713407040228131 0.556668779069766 0.846833338021269 0.984255298070832 0.0751926025514877 0.932296220458457 0.994235539701634 0.0431275780927969 "MET MUT" "Nilotinib_IC_50" 0.522213547356312 0.853303159804623 0.306110579626049 0.846852635388538 0.984255298070832 -0.0750264994340309 0.877226773781042 0.987838063957761 -0.0664099737236239 "ERBB2 MUT" "Axitinib_IC_50" 0.030437658892184 0.323654657213466 0.946795113396133 0.84689147893502 0.984255298070832 -0.0742113731538046 0.281236918138246 0.887872038823822 0.442375649616533 "AKT2 MUT" "AZD.0530_IC_50" 0.820048261919953 0.955629000670661 0.326326670033666 0.846896614330376 0.984255298070832 0.236866668065485 0.62804570693309 0.952146453272921 0.656807974468074 "EGFR MUT" "Nilotinib_IC_50" 0.508336282118051 0.848277813132358 0.231002278656126 0.847051773512664 0.984255298070832 0.0548613634628912 0.83238361400732 0.981482581683432 -0.0696666179871328 "KDR MUT" "JNJ.26854165_IC_50" 0.533195747143484 0.858279561609675 -0.411134861423224 0.847194194726673 0.984255298070832 0.119070249611876 0.755488931287136 0.969901216545994 -0.196557355404876 "EZH2 MUT" "AZD6244_IC_50" 0.89568843073931 0.977104649723106 -0.147474308488611 0.847401890575735 0.984255298070832 0.195746119661184 0.807399950986585 0.977383317127464 0.244544810762784 "PDGFRA MUT" "VX.702_IC_50" 0.41836600045663 0.814099702076568 0.54477418426104 0.847707929524123 0.984255298070832 -0.105905764758075 0.676227568206192 0.960256725054738 0.265482318834124 "BRAF MUT" "NSC.87877_IC_50" 0.491899759850214 0.842990705166559 -0.10900230119027 0.84776956283785 0.984255298070832 0.0329275996686466 0.966035675031656 0.997172246847904 -0.00820037127120418 "MLLT3 MUT" "Lenalidomide_IC_50" 0.948046091904395 0.990899019819731 0.0161617285861714 0.847917229568381 0.984255298070832 -0.0416359698918017 0.994273934156764 0.999545005862799 0.00178843162677905 "FBXW7 MUT" "AZD8055_IC_50" 0.745747559275687 0.930717267274786 -0.100333478725399 0.848053867665604 0.984255298070832 -0.04637930567702 0.835600370766939 0.981626636221501 -0.0664736497407802 "ALK MUT" "Bryostatin.1_IC_50" 0.970561464919962 0.995220468612913 -0.0329544678260869 0.848087541601917 0.984255298070832 -0.161314331210522 0.198617024199219 0.851001889249827 -1.54385336566191 "MET MUT" "Vinorelbine_IC_50" 0.846301263246295 0.961788682268829 -0.119474966565833 0.848135390383553 0.984255298070832 0.0867108575712849 0.680456764498201 0.961100601384891 -0.249140885096456 "CCND1 MUT" "PF.562271_IC_50" 0.81893461272103 0.95524539465489 0.0692380682682679 0.848144459148505 0.984255298070832 -0.0476540269872136 0.955321485412281 0.996100446818628 -0.0178417631929434 "MET MUT" "NVP.BEZ235_IC_50" 0.15988744199295 0.636336191287136 0.69206233939394 0.848201333455789 0.984255298070832 0.0682534306028563 0.32899417803066 0.902810042912437 0.454605973996503 "CDKN2A MUT" "VX.702_IC_50" 0.86308218106591 0.96719657413834 -0.0226225719696974 0.848224063458117 0.984255298070832 -0.021245341511863 0.245307666692803 0.875707386589409 -0.16113002573453 "MAP2K4 MUT" "Camptothecin_IC_50" 0.326807600845259 0.769045655301205 0.643123935525474 0.848266613382033 0.984255298070832 0.0793634456030077 0.792232499381103 0.975393509832241 0.168846492387735 "MYCN MUT" "Gemcitabine_IC_50" 0.456280825865163 0.828966839128293 0.686980842908433 0.848395558889111 0.984255298070832 0.121124282105439 0.598316702067156 0.94937477774851 -0.527922669636139 "ERBB2 MUT" "NVP.TAE684_IC_50" 0.443429570427353 0.825606373270691 0.848161403389829 0.84840033104136 0.984255298070832 0.178571980614147 0.157301060459038 0.837524411233041 1.63275485473025 "EP300 MUT" "Pazopanib_IC_50" 0.64698378690191 0.897186614618066 0.499451079558648 0.848421542447728 0.984255298070832 0.17811113294833 0.325673760276338 0.900918773778407 0.973338180290809 "PIK3R1 MUT" "Cisplatin_IC_50" 0.543396029519229 0.862633715268747 0.358926845969286 0.848779205675047 0.984255298070832 -0.0974414912362166 0.982027599279571 0.997984564504162 0.0127030893147684 "MSH2 MUT" "AZD6244_IC_50" 0.713991283014426 0.91988693852899 -0.312581985416668 0.848829973980469 0.984255298070832 0.147710819646275 0.570170447064654 0.949294892873838 -0.436176568603504 "MSH6 MUT" "Bortezomib_IC_50" 0.884000354979182 0.97404645305274 0.165377756849318 0.848961895458582 0.984255298070832 0.175772212331787 0.967564183517922 0.997173634484198 -0.0435975132556202 "CDH1 MUT" "GDC.0449_IC_50" 0.765357851381024 0.936968974174869 0.138773068783067 0.849232867512657 0.984255298070832 -0.0793374805826763 0.80402790829864 0.976660896667097 0.123618913080788 "PIK3R1 MUT" "XMD8.85_IC_50" 0.197913482567565 0.674012093366938 1.05587989619377 0.849309686983039 0.984255298070832 0.134154158723736 0.148859057581692 0.831473272394224 1.15223034629165 "FGFR2 MUT" "MG.132_IC_50" 0.265198459358696 0.726697783882931 1.52708167231638 0.849317191961985 0.984255298070832 0.236008051216478 0.119027132301214 0.80678720253446 2.41990321783383 "MLLT3 MUT" "Epothilone.B_IC_50" 0.417664038370564 0.814099702076568 -0.420438415381983 0.849347703051341 0.984255298070832 -0.05611813678409 0.815911630700091 0.977383317127464 -0.123110076662417 "EZH2 MUT" "GDC.0449_IC_50" 0.918288610143518 0.985394748720982 -0.056333844660195 0.849358270135583 0.984255298070832 0.0924592102168729 0.783857432736908 0.974078058737889 -0.14889816926575 "CDK6 MUT" "CI.1040_IC_50" 0.430323935585252 0.820918238409269 0.474015095852136 0.849509714788049 0.984255298070832 0.101906889042565 0.164385867608432 0.839927262232576 0.735364576822598 "CCND1 MUT" "NU.7441_IC_50" 0.64302481689403 0.896094514063559 0.135989293388429 0.849577005137891 0.984255298070832 0.0493300507635459 0.213732641151401 0.859314544932072 -0.379471255885842 "FLCN MUT" "A.770041_IC_50" 0.621503267198896 0.888247588669681 0.732499738095242 0.849978616522264 0.984255298070832 -0.227882795425136 0.509127564198476 0.938147991955214 1.64168228082927 "ERBB2 MUT" "Vinblastine_IC_50" 0.0412251829633449 0.3664873372347 0.897251211626834 0.850027892281655 0.984255298070832 0.062193153295793 0.527277351252869 0.94258255967728 0.278690594999425 "KDM5C MUT" "Elesclomol_IC_50" 0.650035290229859 0.898913406720956 -0.700080058823525 0.850205208539797 0.984255298070832 0.243591795524977 0.398542650867042 0.916480913435499 -1.22055949440383 "CTNNB1 MUT" "ABT.888_IC_50" 0.562561169580147 0.871238675201477 0.171899227476805 0.85048794921529 0.984255298070832 0.0472813091890026 0.883344006676459 0.988301482344111 0.0445160306737333 "KDM5C MUT" "GDC.0449_IC_50" 0.659444285020891 0.902400992643984 -0.381469362934362 0.850560892362532 0.984255298070832 -0.146318088895187 0.602556657758847 0.949657634568742 -0.443208516746766 "BRAF MUT" "CCT007093_IC_50" 0.337345102868587 0.77528718153147 0.141899001948575 0.850680354874146 0.984255298070832 -0.0300074630315563 0.597676185212084 0.949294892873838 0.0931505308028212 "CDKN2a(p14) MUT" "Vinorelbine_IC_50" 0.0769238396177581 0.485544150423106 -0.309047631835498 0.850719884681144 0.984255298070832 0.025331542990659 0.910872548530413 0.990141873133243 -0.0215169023049871 "NF2 MUT" "AP.24534_IC_50" 0.859476035157707 0.966322414954601 -0.108916287242169 0.850862957995718 0.984255298070832 -0.104419951098816 0.551137375274654 0.947060194029534 0.371490324347592 "FAM123B MUT" "AP.24534_IC_50" 0.900267243643391 0.97933285041609 0.155801996533794 0.850886759089216 0.984255298070832 -0.210131049953874 0.99337881761178 0.999469155159075 -0.00983443198323333 "EGFR MUT" "Mitomycin.C_IC_50" 0.528306311862724 0.855147571292734 0.297311960838174 0.850919552670618 0.984255298070832 0.069673141443423 0.807640349405892 0.977383317127464 0.117379921171788 "TP53 MUT" "BX.795_IC_50" 0.295087641771389 0.747036827777118 0.159315117605055 0.850944342536133 0.984255298070832 0.0232621632687899 0.806188050692645 0.977383317127464 0.0353478010676271 "FAM123B MUT" "Nutlin.3a_IC_50" 0.956727731214055 0.99327782426188 -0.0586255459882592 0.851305717067173 0.984255298070832 -0.185470645834132 0.809764280245094 0.977383317127464 -0.253476294592096 "KIT MUT" "VX.702_IC_50" 0.625483198233568 0.890758415749171 0.367077183908046 0.85133263377065 0.984255298070832 -0.115269723564223 0.993595434786126 0.999469155159075 0.00565917721309996 "MLH1 MUT" "OSI.906_IC_50" 0.631517456969401 0.893419864692589 -0.285147706784663 0.851509004842527 0.984255298070832 -0.10653607918658 0.667145823704128 0.959230524020512 -0.258567868527457 "IDH1 MUT" "RDEA119_IC_50" 0.829589325806666 0.958015830101332 -0.35668791485149 0.851529847928827 0.984255298070832 0.279289264427014 0.761062057445292 0.969901216545994 -0.433867052238099 "VHL MUT" "ZM.447439_IC_50" 0.839951034978892 0.959424448728358 0.115014602766797 0.851682090779387 0.984255298070832 -0.0850647990003074 0.594784177001066 0.949294892873838 0.310404951303561 "MDM2 MUT" "KU.55933_IC_50" 0.302476332046485 0.752498871456986 0.413140861723444 0.851880075633312 0.984255298070832 0.0665492614290066 0.257395981393289 0.877052916121269 0.444588479480678 "CDKN2A MUT" "CGP.082996_IC_50" 0.043280561696243 0.374123126127403 -0.3985614552737 0.851895478578355 0.984255298070832 -0.0330579072846001 0.597373279614041 0.949294892873838 -0.119629846584973 "EZH2 MUT" "Vorinostat_IC_50" 0.635905649251998 0.894862632072096 -0.300787525691696 0.852102605060763 0.984255298070832 -0.0898176196287551 0.59009520691507 0.949294892873838 -0.31125887731322 "FLCN MUT" "JNK.Inhibitor.VIII_IC_50" 0.526305122240119 0.854969048950887 0.363295726577436 0.852548762228189 0.984255298070832 0.101800532262716 0.321985300884275 0.900918773778407 -0.805899148140607 "CDKN2C MUT" "Elesclomol_IC_50" 0.947875012749925 0.990899019819731 -0.0507317125719774 0.852566584167848 0.984255298070832 0.120058087184382 0.738737771453483 0.96672489654949 0.261842998843614 "SOCS1 MUT" "PD.173074_IC_50" 0.456714361015505 0.828966839128293 -0.75941990234374 0.852824372730316 0.984255298070832 -0.161674491659546 0.756598568448325 0.969901216545994 -0.290511129659424 "CDK4 MUT" "JNK.9L_IC_50" 0.771704354909245 0.9401243314059 -0.141871050522649 0.852866299298553 0.984255298070832 0.0712885548064062 0.906174112031112 0.988917021334873 -0.0606784448007318 "MS-HL MUT" "GDC0941_IC_50" 0.395259190830471 0.8037107527999 -0.215873431394511 0.852908220289901 0.984255298070832 -0.0379362279566519 0.659678071999247 0.958313128388245 -0.121651626147492 "MET MUT" "GSK.650394_IC_50" 0.388407781491531 0.80015066282215 -0.54627594796017 0.853062155417385 0.984255298070832 -0.0761259409363994 0.394474805759593 0.915926348152589 -0.538043459522209 "CTNNB1 MUT" "PF.02341066_IC_50" 0.614642600089154 0.885815598771911 -0.337630812925168 0.853066078311935 0.984255298070832 -0.114144659320601 0.692376379294188 0.961100601384891 -0.288713351991606 "EWS_FLI1 MUT" "FH535_IC_50" 0.421390083038788 0.816041283791426 0.334328816725982 0.853173407178686 0.984255298070832 -0.0707453150509648 0.361713707267519 0.91161229252998 0.414697996985062 "CCND1 MUT" "Tipifarnib_IC_50" 0.418772797774672 0.814099702076568 0.356703392390572 0.853362161514679 0.984255298070832 -0.0546884056073969 0.506091179866765 0.935912793170426 0.309597898568112 "SMARCA4 MUT" "ATRA_IC_50" 0.474219135075529 0.834460661638643 0.394052141472867 0.853406068063106 0.984255298070832 -0.0796801602243397 0.8969689936972 0.988301482344111 -0.0713399482628252 "NF1 MUT" "AICAR_IC_50" 0.211440336468774 0.685329061379264 0.466564944210724 0.853416952578618 0.984255298070832 0.0620174244832428 0.865201310622364 0.987077901072027 -0.0647033073326984 "BRAF MUT" "NVP.TAE684_IC_50" 0.683877561685971 0.910554660150617 -0.226170866359446 0.853592416481468 0.984255298070832 -0.091600493666162 0.816459016224798 0.977383317127464 -0.167077174906061 "BRCA1 MUT" "AMG.706_IC_50" 0.8893901253817 0.975545707993487 0.0895221764705884 0.853593720531181 0.984255298070832 0.109736609678432 0.934805656223096 0.994729228933513 0.0483428229504807 "ERBB2 MUT" "S.Trityl.L.cysteine_IC_50" 0.449955283110774 0.827950185889909 -0.914426540386804 0.853708553884388 0.984255298070832 -0.124572349266113 0.83009046076578 0.981482581683432 -0.271395670694758 "NOTCH1 MUT" "PD.0325901_IC_50" 0.137616098207789 0.60563358185499 0.903096573746748 0.853803557172118 0.984255298070832 0.110262191111688 0.728877664791052 0.965407830614903 0.201215472804266 "VHL MUT" "JW.7.52.1_IC_50" 0.398211588515507 0.80588428316352 1.02442955479452 0.854050941138625 0.984255298070832 0.1390853917119 0.267307951751183 0.877052916121269 1.59662040039816 "BRCA1 MUT" "MK.2206_IC_50" 0.865282519692619 0.967732635968793 0.152077002070392 0.854051200334893 0.984255298070832 0.132000315674303 0.892298565285499 0.988301482344111 0.117905073240305 "KRAS MUT" "VX.702_IC_50" 0.383825255636176 0.798569876743396 0.153811520613109 0.854177891241646 0.984255298070832 -0.0276465089555981 0.981439485837126 0.997957874252292 -0.00443997998939241 "MSH2 MUT" "CHIR.99021_IC_50" 0.657977222607577 0.901751651084414 -0.226114494773519 0.854197762980976 0.984255298070832 -0.0894177533331235 0.208842281003259 0.853446327418758 -0.624177030641253 "SMARCA4 MUT" "Midostaurin_IC_50" 0.993720572059871 0.998970779334534 -0.00469080244755235 0.854485417918942 0.984255298070832 0.084094179342589 0.856447661273769 0.984631915507353 -0.112073906644668 "HRAS MUT" "AZD6482_IC_50" 0.958038626209253 0.993340772343095 0.0464686187175039 0.854601254320548 0.984255298070832 0.137189233639967 0.507094263431696 0.936562389753569 0.572556080447032 "KDM6A MUT" "AMG.706_IC_50" 0.467380658810273 0.831023608668684 -0.223558962813621 0.854722716171475 0.984255298070832 0.0523449096237795 0.330069261708644 0.902810042912437 -0.284801756776311 "JAK2 MUT" "A.443654_IC_50" 0.860717237750704 0.966384100200122 -0.206491397042092 0.854743469905673 0.984255298070832 -0.138712000363527 0.684952421069627 0.961100601384891 0.601953807483628 "CDK4 MUT" "CI.1040_IC_50" 0.641988027342526 0.896094514063559 0.265411529069766 0.854755409810623 0.984255298070832 -0.0937372287837323 0.456184581948585 0.925809648901546 0.393084213607597 "EP300 MUT" "Vorinostat_IC_50" 0.917411963723177 0.984975746996111 0.0760053491124272 0.854944707265697 0.984255298070832 0.102725126469868 0.680740599082467 0.961100601384891 -0.273229956414061 "SMARCA4 MUT" "AKT.inhibitor.VIII_IC_50" 0.780564360833988 0.943283724121192 0.142297631118882 0.854983186838881 0.984255298070832 0.0798855131668026 0.567236796966997 0.949294892873838 -0.326382209079346 "KIT MUT" "Nutlin.3a_IC_50" 0.963445166391932 0.994159243759316 0.0429256784313716 0.855016203539892 0.984255298070832 -0.157020734683477 0.765704860852716 0.969901216545994 0.272338732429827 "KDM6A MUT" "Camptothecin_IC_50" 0.350540872567677 0.784966682190403 -0.532338143518515 0.855044775089621 0.984255298070832 -0.0664433327741202 0.116200310019404 0.802355750183445 -0.817180947682705 "PIK3CA MUT" "BAY.61.3606_IC_50" 0.931796550911318 0.986797659032126 0.023385021457404 0.855090807634102 0.984255298070832 -0.0352765989002858 0.189917609469782 0.851001889249827 -0.368814196296612 "JAK2 MUT" "CI.1040_IC_50" 0.580752957171431 0.875665027612815 0.375731627580509 0.855209555449264 0.984255298070832 -0.111146278062195 0.969039302682455 0.997173634484198 -0.025355428510693 "NF1 MUT" "AP.24534_IC_50" 0.223875869760897 0.696139064632428 0.731254883116875 0.855264299158707 0.984255298070832 0.0994451915790472 0.44671565395195 0.925809648901546 0.465596916775406 "RB1 MUT" "WZ.1.84_IC_50" 0.833067684633661 0.958775297273765 0.0582497306737743 0.855267447882931 0.984255298070832 0.0439156129745843 0.0523174624986403 0.690946762417053 -0.595187134079461 "SMAD4 MUT" "MS.275_IC_50" 0.294832347824542 0.747036827777118 -0.878261007440471 0.855348029299688 0.984255298070832 -0.131421682221662 0.173232394342509 0.844239622796781 -1.25915715826264 "BRCA2 MUT" "Imatinib_IC_50" 0.517919901700313 0.852353345422823 0.63780053872053 0.855506832522145 0.984255298070832 -0.178712692365348 0.53998206352197 0.944569766818715 0.64737619555061 "CDK4 MUT" "Rapamycin_IC_50" 0.674337093063422 0.908418658675584 0.899246305369123 0.85556349597907 0.984255298070832 0.337876540277133 0.362764253800733 0.912255858255809 1.98360563775467 "SMAD4 MUT" "GDC0941_IC_50" 0.317974866197475 0.761258739353268 0.372208152155172 0.85562346887752 0.984255298070832 -0.056221881720016 0.788174283992014 0.975265472692061 0.10567881629231 "SETD2 MUT" "AG.014699_IC_50" 0.946556310732425 0.990414144411092 -0.0683124417040328 0.855662339331659 0.984255298070832 -0.165235929964879 0.771827959141911 0.969901216545994 -0.2737388014707 "RB1 MUT" "Salubrinal_IC_50" 0.459496561903016 0.828966839128293 -0.204082145975206 0.85567019349556 0.984255298070832 -0.0426853498558378 0.0429483046091348 0.658180729724545 -0.651817426448431 "FGFR3 MUT" "NSC.87877_IC_50" 0.657180039831595 0.901751651084414 0.287561485319511 0.855904004293609 0.984255298070832 0.115590884866349 0.69073915935532 0.961100601384891 0.260815972873185 "CDKN2C MUT" "ZM.447439_IC_50" 0.926849114895603 0.98643792569589 -0.0522868102766788 0.855951754219995 0.984255298070832 -0.082444407982208 0.775602741674912 0.972337708041191 0.164302585226732 "FBXW7 MUT" "Bortezomib_IC_50" 0.586435804476584 0.876506729771444 -0.393970905594402 0.856092282679824 0.984255298070832 -0.108593049271688 0.341772673459677 0.907180409180092 -0.676699097830584 "KDM5C MUT" "GW.441756_IC_50" 0.635771009977847 0.894862632072096 -0.408098537001895 0.856167462408321 0.984255298070832 -0.154026567954747 0.595359338023379 0.949294892873838 -0.450202634152174 "TSC1 MUT" "Metformin_IC_50" 0.477015977458912 0.835993679974334 -0.725342775665389 0.856287188837078 0.984255298070832 -0.172542442577855 0.946088943536477 0.995668765770473 0.0675479127848101 "SETD2 MUT" "X17.AAG_IC_50" 0.492120843583619 0.842990705166559 -1.06794094285717 0.856329379063709 0.984255298070832 -0.248981829793344 0.788026536789047 0.975265472692061 0.367127548880694 "EGFR MUT" "Obatoclax.Mesylate_IC_50" 0.972512803394994 0.995376997458908 0.0168880754198716 0.856389780291036 0.984255298070832 -0.0653356291565008 0.630551143405299 0.952523560833852 0.237781115383858 "MET MUT" "CCT018159_IC_50" 0.566398032976489 0.872389778906173 0.247616083916085 0.856580114524282 0.984255298070832 0.0729213154399229 0.806964542389583 0.977383317127464 0.106032220936435 "EGFR MUT" "Vorinostat_IC_50" 0.423519505209669 0.81802451626078 0.22073295119225 0.856799264199581 0.984255298070832 0.0381053789888346 0.864743691883491 0.987077901072027 -0.0449403353529198 "SETD2 MUT" "Sunitinib_IC_50" 0.609613784668917 0.884443710620525 0.85391522789116 0.856853331245973 0.984255298070832 -0.225505432642259 0.792295617275364 0.975393509832241 0.388998506560098 "PIK3CA MUT" "XMD8.85_IC_50" 0.705792441496489 0.916395127621392 0.194969228031755 0.856880869940715 0.984255298070832 0.080384255230203 0.702605551604596 0.962139809888331 -0.21254436060736 "PIK3CA MUT" "GW843682X_IC_50" 0.769322809820034 0.939026921105046 0.202831388136511 0.856932988006098 0.984255298070832 -0.0643062715532629 0.891598417019807 0.988301482344111 0.107112966055771 "MS-HL MUT" "Bexarotene_IC_50" 0.889158015943929 0.975527896272722 -0.0287210569724978 0.857069753970222 0.984255298070832 0.0333484796403046 0.226411644199634 0.866933851943076 -0.265051518646206 "MLH1 MUT" "RDEA119_IC_50" 0.332274978313469 0.773102982028273 0.724011850704226 0.857073381817023 0.984255298070832 -0.123942247451556 0.723751494755356 0.965402608571648 0.228689701552161 "KRAS MUT" "Lapatinib_IC_50" 0.83332806211645 0.958775297273765 0.0831078215488208 0.857213214412278 0.984255298070832 0.0656287876952065 0.179458104840945 0.848722027112292 0.512029499521449 "PDGFRA MUT" "AKT.inhibitor.VIII_IC_50" 0.3597434224168 0.786601117838604 -0.658492497400341 0.857330702202535 0.984255298070832 -0.110731769227009 0.370963448535237 0.913948248824328 -0.638230178080204 "PIK3R1 MUT" "A.443654_IC_50" 0.182842012468656 0.659821175430369 1.21663739518901 0.857362111815021 0.984255298070832 0.106352395467919 0.149361016407109 0.831473272394224 1.33213006149362 "FAM123B MUT" "QS11_IC_50" 0.494492247071186 0.843282996121548 0.601682585664345 0.857530668482367 0.984255298070832 0.116181432389356 0.595726047696012 0.949294892873838 0.462407766218986 "CCND1 MUT" "GSK.650394_IC_50" 0.341902874391117 0.778773897785973 0.389737246195285 0.857625794170419 0.984255298070832 0.0480491014971173 0.441128509556162 0.924472815010418 0.337266499916596 "PTEN MUT" "BI.2536_IC_50" 0.825132609598257 0.957177484110155 -0.0789936935240964 0.857852234874733 0.984255298070832 0.0386548646598179 0.770544804518177 0.969901216545994 -0.116735703215834 "CCND1 MUT" "SB590885_IC_50" 0.361222644356937 0.787050614458772 0.340921763481956 0.857925856435842 0.984255298070832 -0.0563869927876833 0.978552282500936 0.997696419805459 0.00949800803035768 "CTNNB1 MUT" "Sunitinib_IC_50" 0.793663917972915 0.948646027682356 -0.254309389655175 0.858071196258408 0.984255298070832 -0.127107008996766 0.690839866744286 0.961100601384891 -0.375774196832177 "ALK MUT" "DMOG_IC_50" 0.750803208131767 0.932701537476322 0.402624999999999 0.858077759363122 0.984255298070832 0.20423765186506 0.423523890509064 0.922428741067589 -1.34822586385657 "CDKN2C MUT" "BAY.61.3606_IC_50" 0.216775557458637 0.689535718406216 0.752713548500878 0.858110449053771 0.984255298070832 -0.0760724211129473 0.413714209987939 0.921714070263062 0.558371931745442 "SMAD4 MUT" "AZ628_IC_50" 0.332871975077782 0.773185226006147 -0.998671281759762 0.858173933377911 0.984255298070832 0.142983064789138 0.0220666986022375 0.552040423342173 -2.15208739649346 "CDH1 MUT" "CCT007093_IC_50" 0.475916405892168 0.835134084317001 -0.274707803934218 0.858197868911968 0.984255298070832 -0.0696470248524555 0.599935827893649 0.949657634568742 -0.223400483161478 "FBXW7 MUT" "Cisplatin_IC_50" 0.437108238969628 0.823808548892323 0.274645322134385 0.85839249337946 0.984255298070832 0.0552199372869892 0.537726081164745 0.943597179771607 0.221038377051176 "HRAS MUT" "AZD.2281_IC_50" 0.601387819019787 0.880745626033854 0.321209930555553 0.858459133592004 0.984255298070832 0.0830615157057706 0.99903648804656 0.999751228014461 -0.000652736988151383 "SMARCA4 MUT" "SL.0101.1_IC_50" 0.276780376011449 0.735108059249974 0.422378615984402 0.858510665361293 0.984255298070832 0.0601425854491756 0.726771817735696 0.965402608571648 0.148745368035759 "CDH1 MUT" "Imatinib_IC_50" 0.698379760700256 0.914968665673257 0.24304867346939 0.858519248922209 0.984255298070832 0.112769677270046 0.7697079256843 0.969901216545994 0.19892516508455 "JAK2 MUT" "JNJ.26854165_IC_50" 0.67016016974788 0.906882709825482 0.184825215419503 0.858572960938725 0.984255298070832 -0.0726837000257025 0.816420427130225 0.977383317127464 0.103800978554086 "SMARCB1 MUT" "BAY.61.3606_IC_50" 0.807916296249032 0.952641225877339 -0.329186775652177 0.858721846606901 0.984255298070832 0.167128292351392 0.681713074787626 0.961100601384891 -0.527977587045307 "FBXW7 MUT" "JNK.9L_IC_50" 0.676674349617425 0.908720747099578 -0.124479384740258 0.858795305859383 0.984255298070832 -0.0415895838888199 0.991190663613117 0.99917869279774 -0.00339916234066167 "MSH2 MUT" "Parthenolide_IC_50" 0.818018429901715 0.955165737441734 0.165446530612246 0.858909939084849 0.984255298070832 -0.119270852432918 0.860873971018313 0.985524480087535 0.131298475415155 "PIK3R1 MUT" "Parthenolide_IC_50" 0.586983854350488 0.876506729771444 0.390510136054424 0.85896479848775 0.984255298070832 -0.118227541697472 0.525390451729129 0.940554660491705 0.464865610497698 "EWS_FLI1 MUT" "Vorinostat_IC_50" 0.00574540448504546 0.131507570184765 -0.943930144297248 0.859103290071725 0.984255298070832 0.0500047559653865 0.634618607300326 0.952678811939519 0.171836494604801 "MYCN MUT" "NSC.87877_IC_50" 0.774619869669387 0.941591338606299 0.0747656258764149 0.859326226771866 0.984255298070832 0.0463972270273127 0.525438027030521 0.940554660491705 -0.194243266472273 "IDH1 MUT" "Cisplatin_IC_50" 0.601788725954357 0.880745626033854 -0.612942271347245 0.859531431610092 0.984255298070832 0.179323298671077 0.699137392710503 0.961100601384891 -0.437665337352804 "CCND3 MUT" "Obatoclax.Mesylate_IC_50" 0.598365019735128 0.879232253518807 0.608653688917987 0.859613388748475 0.984255298070832 0.150179803026376 0.819859817248811 0.977383317127464 0.252641277840028 "CDKN2a(p14) MUT" "AZD7762_IC_50" 0.0172273502181361 0.240182256337938 -0.380399111454683 0.85971004263893 0.984255298070832 0.0229551625814683 0.577917406863705 0.949294892873838 -0.0905042456213711 "MYCN MUT" "TW.37_IC_50" 0.664868674179223 0.903873756743204 -0.148806134259259 0.859955098100876 0.984255298070832 -0.0572658329824403 0.216174602127866 0.860576337437605 0.511643724982349 "PIK3R1 MUT" "OSI.906_IC_50" 0.519896000809505 0.852599738673405 0.466905721001759 0.860101716995545 0.984255298070832 0.120969949801878 0.498688936796643 0.934042323734638 0.491006936063474 "CDK4 MUT" "Bleomycin_IC_50" 0.789752109244619 0.947425163069223 -0.313093293057999 0.860106327514475 0.984255298070832 0.169369015849341 0.848002417959941 0.98378870157398 -0.230161608678584 "SMARCB1 MUT" "Bryostatin.1_IC_50" 0.63980414527139 0.895624997957207 -0.417848589565221 0.860151261688511 0.984255298070832 -0.14782405688744 0.718426669393869 0.964721180904622 -0.311468237727442 "PIK3CA MUT" "Vinorelbine_IC_50" 0.386177485385921 0.798891741838427 -0.250613521675086 0.860173353768273 0.984255298070832 -0.0377327104741764 0.370805773391353 0.913948248824328 -0.279154184559091 "CDKN2C MUT" "Sunitinib_IC_50" 0.584402820961469 0.876506729771444 0.531706702298852 0.860352323789726 0.984255298070832 0.126474797029327 0.67073113617756 0.95968474631753 0.438967206003382 "AKT2 MUT" "Axitinib_IC_50" 0.437665944274816 0.823808548892323 0.566556919056722 0.860371780698004 0.984255298070832 0.108436923808066 0.475835338832938 0.929855889225741 0.460846360934337 "JAK2 MUT" "IPA.3_IC_50" 0.363973268534545 0.787306955898826 0.712363434085225 0.86058105611071 0.984255298070832 0.115779635672959 0.347745838277793 0.909999728614578 0.744668129226239 "MLH1 MUT" "GNF.2_IC_50" 0.340627100634284 0.778503205456979 0.42790356597222 0.860612314140894 0.984255298070832 0.0761338808530586 0.40996297502922 0.921138279485245 0.38190307497476 "TP53 MUT" "NSC.87877_IC_50" 0.868632065571463 0.968770736448595 0.0162393835254321 0.860733434823752 0.984255298070832 -0.0176001745443072 0.738307966740946 0.96672489654949 0.0359165677302077 "SETD2 MUT" "Bicalutamide_IC_50" 0.366507311254505 0.788882799008227 -0.396658817391309 0.860734593066547 0.984255298070832 -0.0738414908529976 0.802205500673052 0.976365695720597 -0.103230665595672 "PDGFRA MUT" "AZD6244_IC_50" 0.691105815642682 0.912932803156675 0.400150298755185 0.86079393087672 0.984255298070832 -0.160894206432159 0.836532108963289 0.981626636221501 0.188837807890136 "CDK6 MUT" "BIBW2992_IC_50" 0.801379735243072 0.9507092914502 -0.160402785256409 0.861236410853024 0.984634470235029 0.106853590623031 0.859884386648731 0.985479880500142 0.103833550754917 "MAP2K4 MUT" "Z.LLNle.CHO_IC_50" 0.983725673181455 0.996723172778267 -0.0214905813424341 0.861444183581386 0.984745243195558 0.168986543624893 0.951453029507526 0.995669074626174 0.076078786585768 "BRAF MUT" "BIRB.0796_IC_50" 0.70990422727651 0.91855665481614 -0.064443089368258 0.861747434087574 0.984965117391473 0.030669248046756 0.0528568926803597 0.694693703793562 -0.394954147273551 "EP300 MUT" "Rapamycin_IC_50" 0.525736278815249 0.854969048950887 -1.35764966778522 0.861865252816026 0.984973016376158 0.320442429908917 0.612365742881256 0.949930222127033 -1.09921368164917 "MAP2K4 MUT" "Midostaurin_IC_50" 0.487484139671606 0.841054887180408 -0.363830935379206 0.862190272985145 0.98512401848757 -0.0701647980465934 0.0726805779769526 0.737687100586647 -0.938640098605128 "NF1 MUT" "Nutlin.3a_IC_50" 0.9627251672306 0.994159243759316 0.019002698817443 0.862349870083801 0.98512401848757 -0.0650844743170793 0.97553510358831 0.99742775226181 0.01311929002647 "EZH2 MUT" "Obatoclax.Mesylate_IC_50" 0.984568739947947 0.996723172778267 -0.0169404426065159 0.862418773184946 0.98512401848757 0.111034722236032 0.838027796282721 0.981704379975756 0.184937896547418 "CDH1 MUT" "PD.173074_IC_50" 0.655703188071638 0.901579193878962 0.228849397233199 0.862467522424294 0.98512401848757 0.0766803803004407 0.551658164382244 0.947060194029534 -0.302084795959403 "STK11 MUT" "BAY.61.3606_IC_50" 0.150444053220184 0.625010754600796 0.572637810126586 0.862651632139644 0.98512401848757 -0.0480287924236927 0.60928133283174 0.949930222127033 0.203537784023288 "CCND3 MUT" "CCT007093_IC_50" 0.935811357874975 0.98822124486179 0.0577506696428567 0.862751505291754 0.98512401848757 0.124384176366299 0.994956463304488 0.999545005862799 -0.00456149495724505 "ALK MUT" "TW.37_IC_50" 0.49570741782623 0.843528947636472 -0.651322067264563 0.862773856074352 0.98512401848757 0.150140895126879 0.738165537123268 0.96672489654949 -0.311020509020226 "FLT3 MUT" "Lenalidomide_IC_50" 0.364938883742582 0.787611719688425 -0.55663159062103 0.863113916089714 0.985304780806415 0.093989342143028 0.891747679838242 0.988301482344111 0.08054378398612 "MET MUT" "ABT.263_IC_50" 0.61559066660937 0.885815598771911 0.332907176396171 0.863433577917857 0.985304780806415 -0.102912254499775 0.554422562244358 0.948071221654821 -0.339735113105098 "MSH2 MUT" "ZM.447439_IC_50" 0.628556134828269 0.891947858940054 -0.294206496759648 0.863556697479104 0.985304780806415 -0.0832049806440738 0.913041091347568 0.99082410867764 -0.0632348318848314 "KRAS MUT" "Roscovitine_IC_50" 0.196237986560328 0.672372514908285 -0.478544444444443 0.863605934990258 0.985304780806415 -0.0612559250576662 0.397982292443829 0.916480913435499 -0.345232170131597 "EP300 MUT" "NVP.TAE684_IC_50" 0.553401181669277 0.866799981376517 -1.03201874496643 0.863680379679765 0.985304780806415 -0.245022621327568 0.932096479115325 0.994235539701634 -0.148883611436733 "MS-HL MUT" "Camptothecin_IC_50" 0.368373046311497 0.789246419666677 -0.271228864398115 0.863771705335061 0.985304780806415 0.0327672640005524 0.836609842310612 0.981626636221501 -0.060016445378394 "KIT MUT" "MG.132_IC_50" 0.546004603813833 0.86289571535809 -1.01251033783783 0.863815288881888 0.985304780806415 0.262789033773793 0.661924064613968 0.958689538788368 0.687642961804316 "EWS_FLI1 MUT" "WH.4.023_IC_50" 0.135900509136502 0.60335156031289 1.62414699393937 0.863889116677146 0.985304780806415 0.179680075659455 0.558404139301096 0.94928677421639 0.68668747061737 "CCND3 MUT" "PLX4720_IC_50" 0.444792127042959 0.825606373270691 1.02305141108987 0.864086894936727 0.985304780806415 -0.203477773611675 0.38491447535883 0.915331032347709 1.04919873318723 "FGFR2 MUT" "SL.0101.1_IC_50" 0.839952358057728 0.959424448728358 -0.174123320537426 0.86412123484758 0.985304780806415 -0.129781275504685 0.46457266206601 0.929276781658587 -0.854590770305945 "TP53 MUT" "GSK.650394_IC_50" 0.938635519228367 0.989080507581691 -0.0141009893945484 0.864152565893612 0.985304780806415 -0.0212333772317237 0.812606840348851 0.977383317127464 -0.0466648934522458 "BRCA2 MUT" "AZD6244_IC_50" 0.215888399740945 0.688608753079032 1.39091130227741 0.864426308575316 0.985378968934017 0.176193793773989 0.119384998675857 0.807345933536413 1.56997262872746 "BRCA2 MUT" "Pyrimethamine_IC_50" 0.434040002563431 0.823150425912549 1.28977986440677 0.864594515786664 0.985378968934017 0.238725731029866 0.444030650600664 0.925809648901546 1.28478843296188 "STK11 MUT" "WZ.1.84_IC_50" 0.658062431108894 0.901751651084414 -0.334422886597939 0.864601375318853 0.985378968934017 -0.107519898973684 0.934924251520369 0.994729228933513 0.0668191236849805 "JAK2 MUT" "KU.55933_IC_50" 0.967250233126746 0.994434372972651 0.0211636182902586 0.864757606885757 0.985378968934017 -0.0780575054315254 0.506164630099481 0.935912793170426 -0.372837550594595 "CCND3 MUT" "Gefitinib_IC_50" 0.390721507791336 0.801837403580487 0.986972222011378 0.864772399940517 0.985378968934017 0.176144728320275 0.310416837146436 0.89718581932126 1.0455342822242 "ERBB2 MUT" "RO.3306_IC_50" 0.333904649145057 0.773264085106582 0.350148311042725 0.865383723236606 0.985742945333205 -0.0607427552593984 0.816160398126819 0.977383317127464 0.0899190879782825 "MSH2 MUT" "AP.24534_IC_50" 0.356646538660687 0.786601117838604 -0.907987182055751 0.86541100234332 0.985742945333205 -0.15111815141459 0.500431875628622 0.934042323734638 -0.629377880945245 "CDH1 MUT" "Embelin_IC_50" 0.315751282478855 0.761258739353268 0.482324923708925 0.865569008467226 0.985742945333205 0.0659126343123937 0.487222007347091 0.933639405738697 0.353855050293492 "EGFR MUT" "PF.02341066_IC_50" 0.428749794922038 0.820918238409269 0.41376393448276 0.865680815055784 0.985742945333205 0.080906684563784 0.345324300821415 0.908688923139256 0.489289068168722 "BRCA1 MUT" "PD.0325901_IC_50" 0.743560094792552 0.929570057037101 -0.368934515904578 0.865926539872037 0.985742945333205 0.17994331220426 0.630028104792042 0.952523560833852 -0.473549896857615 "CDK4 MUT" "MG.132_IC_50" 0.309454667451319 0.756889810420041 -1.70349783783783 0.865990827783922 0.985742945333205 0.252324957679405 0.993100478668489 0.999469155159075 0.0135617807070391 "KDM5C MUT" "Metformin_IC_50" 0.734049345738528 0.928593402067957 -0.346608174904942 0.866042796107266 0.985742945333205 -0.161552988823311 0.805068104697516 0.976878758490379 -0.244934641919179 "JAK2 MUT" "AZD.0530_IC_50" 0.841494539730828 0.959741495283223 0.234631377252254 0.866082304596318 0.985742945333205 -0.170290121097708 0.978698374850174 0.997696419805459 -0.0363852291337061 "KIT MUT" "Vorinostat_IC_50" 0.780512772630194 0.943283724121192 -0.177049531620552 0.866090778339714 0.985742945333205 -0.0819148011345193 0.342713158948061 0.907180409180092 -0.553896743534054 "ALK MUT" "Bleomycin_IC_50" 0.776470178742757 0.941591338606299 0.663300072173919 0.866441319890625 0.986015551249184 0.320466553539304 0.58228324182175 0.949294892873838 -1.74406297609392 "NF2 MUT" "Gefitinib_IC_50" 0.496166470831649 0.843896642253943 0.246006120266216 0.866584590441619 0.986052241859323 -0.055044970997673 0.531266807723452 0.94320946427311 0.217991256595115 "MDM2 MUT" "Obatoclax.Mesylate_IC_50" 0.200040331697812 0.674012093366938 0.940845212169312 0.866698570796587 0.986055599185817 0.0904980666657709 0.235136674715311 0.869962136993019 0.833523625902552 "KIT MUT" "AUY922_IC_50" 0.294687780589612 0.747036827777118 -0.890830798951055 0.867138810454136 0.986316713820799 -0.0957262942777131 0.471084360988477 0.929276781658587 -0.586721359859817 "GNAS MUT" "ABT.263_IC_50" 0.569187819731891 0.872389778906173 0.441236354743078 0.867391652546818 0.986316713820799 -0.11639408657888 0.7392349704751 0.96672489654949 0.223547862421562 "RB1 MUT" "Lenalidomide_IC_50" 0.293064253383794 0.747036827777118 -0.155235240500768 0.867409225276065 0.986316713820799 -0.0222204034615545 0.150572088506072 0.831473272394224 -0.224964303035574 "MDM2 MUT" "PF.562271_IC_50" 0.372215569734124 0.791771610732635 0.436703564685313 0.867549787175518 0.986316713820799 0.0666214928459394 0.294768353428261 0.894167310052 0.501685005962745 "FGFR2 MUT" "A.770041_IC_50" 0.174054314883031 0.651401757469953 2.01394361564627 0.867628581068035 0.986316713820799 -0.205605379844151 0.870000754802138 0.98753907730331 0.28141165254005 "PIK3R1 MUT" "PF.562271_IC_50" 0.305307555057955 0.754224310561809 0.598001091428582 0.867960786494923 0.986316713820799 -0.0790239832619526 0.433701448678234 0.922569292988365 0.446775827826168 "CCND1 MUT" "Embelin_IC_50" 0.664160459445354 0.903589924015879 0.12251612996633 0.868069178088946 0.986316713820799 -0.0377213978903261 0.597431137142042 0.949294892873838 0.158069779992216 "FLT3 MUT" "GW.441756_IC_50" 0.717738115550291 0.92132587844031 0.254571396070972 0.868111006077579 0.986316713820799 0.115346068822718 0.607046789624269 0.949657634568742 0.360714183913798 "CDH1 MUT" "Paclitaxel_IC_50" 0.439763158319823 0.824500931653809 -0.907105226027393 0.86839778142972 0.986316713820799 -0.0868250449588122 0.954202839440462 0.99568364368633 -0.0690995129906807 "MLH1 MUT" "CI.1040_IC_50" 0.97844695704835 0.996276778834563 0.0147208047661082 0.86843191885953 0.986316713820799 -0.0816902718362701 0.537155734137132 0.943443271455699 0.298974806160306 "GNAS MUT" "GW843682X_IC_50" 0.417614402945689 0.814099702076568 -1.1464524659864 0.868434023882321 0.986316713820799 0.120813734622885 0.771575915421377 0.969901216545994 -0.428281812480696 "IDH1 MUT" "PF.562271_IC_50" 0.846410007008029 0.961788682268829 -0.210573553448278 0.868448532160643 0.986316713820799 0.146310752186616 0.873072123057921 0.987739302532152 0.171563297584614 "EWS_FLI1 MUT" "TW.37_IC_50" 0.026195140012668 0.300179404454845 -0.842089235366943 0.868493900060698 0.986316713820799 0.0632339542830801 0.169850351368113 0.84067330207935 0.646277551836715 "KDR MUT" "BI.D1870_IC_50" 0.970330967249913 0.995220468612913 0.0346565884223901 0.868561125286308 0.986316713820799 0.133096324099091 0.622462690316858 0.950496524771391 -0.439542310726132 "JAK2 MUT" "PF.562271_IC_50" 0.533399152185113 0.858279561609675 0.36342834111802 0.86876649866425 0.986316713820799 -0.0786310395439937 0.47148757355706 0.929276781658587 0.448637547865518 "NF2 MUT" "Docetaxel_IC_50" 0.317754998700103 0.761258739353268 -0.402071551865638 0.868775480945713 0.986316713820799 0.0499671344243873 0.616591750601343 0.950247055931602 0.207686246722242 "FGFR3 MUT" "MS.275_IC_50" 0.369283193767099 0.789535578103719 -1.39646130716725 0.868916502019134 0.986316713820799 0.212455984497356 0.45080272000238 0.925809648901546 -1.22130501687073 "CCND3 MUT" "Thapsigargin_IC_50" 0.800368833845852 0.950688474635998 -0.365091176265278 0.868974473117057 0.986316713820799 -0.182033810473439 0.739675499519726 0.96672489654949 -0.466524827524061 "FLT3 MUT" "Pazopanib_IC_50" 0.351593302507812 0.784966682190403 -0.880315090750456 0.869038203541015 0.986316713820799 -0.134010654862846 0.252329957229686 0.875707386589409 -0.99447241417012 "EGFR MUT" "IPA.3_IC_50" 0.612353706144554 0.88496040166963 0.222557273426463 0.869161930168586 0.986331088912243 0.0610532391460255 0.77165062353036 0.969901216545994 -0.124586394077862 "PIK3R1 MUT" "SB590885_IC_50" 0.368936084916496 0.789246419666677 0.582639518442619 0.869464528979629 0.986464331549395 0.089162478808146 0.513977608664333 0.939635632721979 0.368872779761268 "VHL MUT" "Bexarotene_IC_50" 0.376622312751065 0.795051761241315 -0.505432062390157 0.869658405416471 0.986464331549395 -0.0840440229182284 0.893734684085656 0.988301482344111 0.0790908676808807 "CDK4 MUT" "JNK.Inhibitor.VIII_IC_50" 0.52207841649882 0.853303159804623 0.23346330754352 0.869707029172417 0.986464331549395 0.0573085547822426 0.709126959584076 0.962630898212352 0.143640936612834 "EZH2 MUT" "PF.4708671_IC_50" 0.742959395988919 0.929570057037101 0.193516554054055 0.869723647790987 0.986464331549395 0.0948450270966191 0.883119733032254 0.988301482344111 0.0879198895054978 "NF2 MUT" "Nilotinib_IC_50" 0.714039709662443 0.91988693852899 0.133687400262467 0.870077936222979 0.986588246053989 -0.0485197582575603 0.542524784680919 0.945765861891114 -0.213595915233544 "MAP2K4 MUT" "GW.441756_IC_50" 0.654302603862748 0.900959366288538 -0.159038305609286 0.87016019841208 0.986588246053989 -0.056892984269189 0.398944859233176 0.916480913435499 -0.328763047184781 "KDM6A MUT" "Cyclopamine_IC_50" 0.256765756202946 0.721056525769268 -0.475108075554341 0.870166167249285 0.986588246053989 -0.0630642598168841 0.179767885173895 0.848722027112292 -0.618170986523756 "EP300 MUT" "JNK.Inhibitor.VIII_IC_50" 0.778235290285876 0.942157839037845 0.186290407124687 0.870325383051733 0.986642804044222 -0.103641046028082 0.756560790747489 0.969901216545994 0.2053163987959 "CDKN2C MUT" "BIBW2992_IC_50" 0.793018372713964 0.948304071878264 0.177287235364682 0.870682101017961 0.986921217503575 0.105496556597985 0.225822944947596 0.86643108387559 -0.808963994917948 "MET MUT" "BIRB.0796_IC_50" 0.447817220287321 0.826231147407263 0.269459999999998 0.870930378085909 0.987076657450352 0.0553351194491046 0.699556996259708 0.961100601384891 0.135371919678834 "FBXW7 MUT" "Erlotinib_IC_50" 0.999025102786421 0.999548905963057 -0.000753838289962711 0.871106746945055 0.987150570322704 0.0911206216316845 0.742784843314495 0.966725278648091 -0.205235536990117 "CCND1 MUT" "FH535_IC_50" 0.887944486136362 0.975214727041194 0.0441579270033668 0.87132295343226 0.987269603142625 0.0438514198886226 0.98790461637302 0.998132070308167 -0.00487762985996196 "MLH1 MUT" "AP.24534_IC_50" 0.593451707919399 0.878261059495448 -0.430968711403509 0.871459924680542 0.987298838000751 0.119116587988028 0.989473941675448 0.998596878102629 0.010082568578944 "KDM6A MUT" "LFM.A13_IC_50" 0.986106967288872 0.996887811168928 0.00428122644741341 0.871607716697454 0.987340322957919 0.0374973071789073 0.737195366781601 0.96672489654949 -0.0869951309478404 "ALK MUT" "GSK.650394_IC_50" 0.990680531952131 0.998036562927507 0.0172189182608735 0.871919375882128 0.987546784404435 -0.153466568783106 0.748892033922592 0.968780465757047 -0.66178085150645 "BRCA1 MUT" "NSC.87877_IC_50" 0.883275268238734 0.973927829424842 0.07382006932409 0.872139727672407 0.987546784404435 0.0796368884959407 0.768695834289251 0.969901216545994 0.150458422252196 "NF1 MUT" "AS601245_IC_50" 0.209031961232291 0.683258317152734 0.481218851357717 0.872153840672361 0.987546784404435 -0.0497449330962321 0.810946972548663 0.977383317127464 0.0980863419038316 "JAK2 MUT" "WZ.1.84_IC_50" 0.798353404852382 0.949557787195058 0.248390284414105 0.872331182598415 0.987546784404435 -0.129590390657107 0.488530855140924 0.933639405738697 0.789728077773004 "NF2 MUT" "PF.02341066_IC_50" 0.554131629856507 0.866925654369292 -0.309391237931037 0.872345965955724 0.987546784404435 -0.0791420144195806 0.457220962597263 0.925841766232465 -0.417702007435849 "NF2 MUT" "BIBW2992_IC_50" 0.694632024524079 0.913615900582776 0.165788534401949 0.872983550286941 0.987878437124413 -0.0651800773218274 0.945323348730963 0.995668765770473 0.0286004910152419 "PIK3R1 MUT" "AZ628_IC_50" 0.434855184605046 0.823150425912549 0.949907391752583 0.873005338232462 0.987878437124413 -0.144227777202517 0.65494260796004 0.958313128388245 0.465338595563181 "VHL MUT" "BI.D1870_IC_50" 0.685831068468038 0.9116697678588 0.231913138728322 0.873101557969027 0.987878437124413 0.0794212287150144 0.539009351048001 0.944569766818715 0.362097720525151 "EP300 MUT" "Imatinib_IC_50" 0.789692113382743 0.947425163069223 -0.263176060606058 0.87321303681496 0.987878437124413 -0.155135556598389 0.871374356395179 0.987579844199283 0.168852349507722 "CDH1 MUT" "WH.4.023_IC_50" 0.852543557732014 0.964196154467744 -0.297711457044675 0.873312604300497 0.987878437124413 -0.227267010936058 0.607550069821502 0.949657634568742 -0.787419291648954 "BRCA1 MUT" "CHIR.99021_IC_50" 0.958330482681866 0.993340772343095 -0.0336706585788554 0.873354579793882 0.987878437124413 0.0973986704386051 0.958720678432294 0.99641548698706 -0.0322786666362998 "KIT MUT" "NVP.TAE684_IC_50" 0.939576422547722 0.989446598697723 -0.132032838926173 0.873417575532135 0.987878437124413 0.236887253427685 0.401394376771713 0.916589616820582 1.47668465001888 "MLH1 MUT" "Lenalidomide_IC_50" 0.486442205126149 0.84074437879216 -0.225060854685853 0.873586929684125 0.987889691895677 0.0456916382198252 0.766808560472947 0.969901216545994 0.0927506148759233 "KDM5C MUT" "CCT018159_IC_50" 0.61280198292269 0.88496040166963 -0.414674370709376 0.873792521480494 0.987889691895677 -0.121581262696532 0.74918262986643 0.968780465757047 -0.263389806715369 "NF1 MUT" "Mitomycin.C_IC_50" 0.0726824805183431 0.476378678585539 0.845181838251456 0.87391409984991 0.987889691895677 0.0589717382864303 0.684159494559071 0.961100601384891 0.20179560120938 "CDK4 MUT" "BMS.708163_IC_50" 0.809298810896976 0.952641225877339 -0.0986305600907029 0.873971606233945 0.987889691895677 -0.0653473367139267 0.514587715777992 0.939635632721979 -0.285084547589573 "IDH1 MUT" "WO2009093972_IC_50" 0.993264441814931 0.998970779334534 0.0092232165898614 0.874066704979965 0.987889691895677 0.154257846682052 0.799386929782294 0.976360691959787 0.276148861766206 "NF1 MUT" "Elesclomol_IC_50" 0.736513081682699 0.928872455997232 -0.15960355764748 0.874094974504479 0.987889691895677 -0.0627580317531243 0.845508042210265 0.98378870157398 -0.0927468973519437 "CDH1 MUT" "Obatoclax.Mesylate_IC_50" 0.357452760441512 0.786601117838604 0.711809246478879 0.874206180453567 0.987889691895677 -0.091188264282284 0.930289284641733 0.99422596912377 -0.0695350419595413 "APC MUT" "BAY.61.3606_IC_50" 0.378523670324754 0.795952477739693 0.310710097128674 0.874468787236579 0.987894771116542 0.0406164785926213 0.844377225680212 0.983349844199673 -0.0792031909188487 "KDR MUT" "VX.702_IC_50" 0.456406098434184 0.828966839128293 0.646053773103896 0.87459985076521 0.987894771116542 -0.111951770427312 0.680578592587102 0.961100601384891 0.33566043041884 "BRCA2 MUT" "Elesclomol_IC_50" 0.134828827672979 0.601893367640051 1.46202208091605 0.874602886169911 0.987894771116542 0.129205560402297 0.520735804066604 0.939635632721979 0.599394584130529 "JAK2 MUT" "Bosutinib_IC_50" 0.385850012332548 0.798746759187088 0.592806653021973 0.8747146860131 0.987894771116542 0.0885309380383136 0.480634501745075 0.930304161706959 0.485845112128348 "TSC1 MUT" "CI.1040_IC_50" 0.824469304922809 0.957177484110155 0.280984062977102 0.874766859594695 0.987894771116542 -0.179134493379612 0.599845666935715 0.949657634568742 0.585043842015321 "NOTCH1 MUT" "OSI.906_IC_50" 0.973564827618093 0.995472410100622 -0.0171252179144388 0.874972617003752 0.987899686949931 0.0794129171891237 0.72048374317328 0.965402608571648 -0.204768224886387 "FBXW7 MUT" "WZ.1.84_IC_50" 0.594754154538763 0.878724279896649 -0.301654672861012 0.875191873965829 0.987899686949931 -0.0750638054023827 0.391509020244023 0.915926348152589 -0.473965156331887 "MYCN MUT" "Bortezomib_IC_50" 0.142173907383507 0.614525525365426 0.763897626811597 0.875196186065322 0.987899686949931 0.0682977573543244 0.624062266999576 0.950496524771391 -0.286855639721012 "EP300 MUT" "Nutlin.3a_IC_50" 0.409984357729958 0.812154538049528 0.88991065753426 0.875216162247726 0.987899686949931 0.156157486227856 0.454699791850337 0.925809648901546 0.776707177039275 "CDK6 MUT" "ZM.447439_IC_50" 0.218998339413586 0.692453909775927 0.660173958415843 0.875617905813848 0.988197532705616 0.0667920748269064 0.377483899189861 0.914419412871569 0.447277158107575 "PTEN MUT" "Pazopanib_IC_50" 0.528554598232277 0.855149978220034 -0.139458828359637 0.87578270598177 0.988197532705616 -0.0301087977352587 0.479051909545945 0.930304161706959 0.1548935128366 "MYCL1 MUT" "SL.0101.1_IC_50" 0.978860257301025 0.996276778834563 0.0122710686600223 0.875813847531348 0.988197532705616 0.0629218359481188 0.585388967453285 0.949294892873838 0.267047996267632 "PIK3R1 MUT" "AZD6244_IC_50" 0.714909149510045 0.920308547391321 0.291716537578286 0.875933707390544 0.988207222476553 -0.113293717692221 0.883423886036854 0.988301482344111 -0.104238480348195 "CDK4 MUT" "Pyrimethamine_IC_50" 0.922040379501953 0.986140039233073 0.161431559322035 0.876583264787864 0.988703067021337 0.218353200569967 0.897237069102842 0.988301482344111 -0.214848315621941 "KDM5C MUT" "SL.0101.1_IC_50" 0.851444777915777 0.963639744191413 -0.131964423076921 0.876595873181624 0.988703067021337 -0.0953222193982522 0.96986445221762 0.997173634484198 0.0254183844185059 "PTEN MUT" "Pyrimethamine_IC_50" 0.690111254201943 0.912742406612613 0.144898445523371 0.876756101082942 0.988758213805411 0.0484048733229371 0.887259170909926 0.988301482344111 -0.056666808343894 "CDKN2C MUT" "NU.7441_IC_50" 0.74623542807564 0.93106446146948 0.164987173652694 0.877204034126411 0.988971650860345 0.0695154183814728 0.184936982358033 0.851001889249827 0.696524721019001 "BRCA1 MUT" "Paclitaxel_IC_50" 0.594284079181798 0.878468193610776 0.984022318644064 0.877205935671389 0.988971650860345 0.124491243353615 0.728378740038775 0.965402608571648 0.64969127423213 "BRAF MUT" "Bexarotene_IC_50" 0.125552225825146 0.586857535554275 -0.348463004353881 0.877279435365139 0.988971650860345 -0.0344465639594544 0.65900269329801 0.958313128388245 -0.114842604462236 "ERBB2 MUT" "Elesclomol_IC_50" 0.0829530216363671 0.498552626562699 0.929714746438414 0.87746383628951 0.989053982749986 0.0709856573020055 0.197570602603723 0.851001889249827 0.696677466654887 "KDM5C MUT" "XMD8.85_IC_50" 0.739570284669206 0.929570057037101 0.351199759450169 0.87788704379744 0.989164619547113 -0.140367765478228 0.848942217423093 0.984263163568471 0.196453256458022 "MLLT3 MUT" "CMK_IC_50" 0.925374436888182 0.98643792569589 -0.0514665706293712 0.878027146420412 0.989164619547113 -0.0766712281620919 0.95668214032714 0.996361528879345 -0.0322377909287583 "RB1 MUT" "MG.132_IC_50" 0.401680511552672 0.806415132522709 0.317731999654935 0.87810174182965 0.989164619547113 0.0530551608418683 0.807573554510257 0.977383317127464 -0.100820751433188 "SMO MUT" "QS11_IC_50" 0.482704274987552 0.839032590911741 -0.974928603478264 0.878173046365729 0.989164619547113 0.15583643607921 0.282601711690717 0.8879937007725 -1.44973615597666 "FLCN MUT" "GNF.2_IC_50" 0.676002494601132 0.908661532914054 0.304019887372013 0.878331381468292 0.989164619547113 0.106053735985784 0.474918822730225 0.929844139269115 -0.932228998125603 "EZH2 MUT" "Temsirolimus_IC_50" 0.891016965949144 0.975972789421281 0.140412171755728 0.878382299494901 0.989164619547113 0.119220577953148 0.889241983830784 0.988301482344111 -0.13510133182603 "HRAS MUT" "JNK.Inhibitor.VIII_IC_50" 0.703663751685802 0.915500829364901 0.178428035828537 0.878450602212599 0.989164619547113 0.0686462064248101 0.639509735159385 0.954756033698446 0.221213219123585 "MET MUT" "AZD.0530_IC_50" 0.582605467537609 0.876506729771444 0.788216232323222 0.878453334489809 0.989164619547113 0.188514045184475 0.211771665738832 0.855272470862467 1.68531421837007 "MLL_AFF1 MUT" "WZ.1.84_IC_50" 0.410927696444023 0.812480994891775 -0.976944829931976 0.878659659817602 0.989164619547113 -0.154612957836833 0.235244689630178 0.869962136993019 -1.34486247566938 "AKT2 MUT" "GW.441756_IC_50" 0.692736419008354 0.913066921534475 0.197332544933078 0.878675789168694 0.989164619547113 0.0745735722924476 0.505383142835446 0.93586286551405 0.332447835720725 "FGFR3 MUT" "AZD7762_IC_50" 0.848858188217201 0.963413363521656 -0.241316169523814 0.878965943537823 0.989195166268587 -0.150730029314086 0.611714580434872 0.949930222127033 -0.5832594051501 "EP300 MUT" "Vinblastine_IC_50" 0.295372839007884 0.747204646998838 -1.08182255766792 0.879016259942592 0.989195166268587 0.114397297026976 0.326981057879855 0.902483952227875 -0.945610868296087 "MAP2K4 MUT" "AZD7762_IC_50" 0.491880880437016 0.842990705166559 0.358664747249188 0.87903707377454 0.989195166268587 0.0620909211704139 0.771128180524844 0.969901216545994 -0.152981828715232 "BRAF MUT" "AP.24534_IC_50" 0.368623280423493 0.789246419666677 -0.352503715370018 0.879348757095021 0.989332343236444 0.059164893758038 0.29142853855736 0.89121914154694 -0.465236857031299 "KDM5C MUT" "Bicalutamide_IC_50" 0.595231217102051 0.878837476080544 0.16533726876091 0.879381772042393 0.989332343236444 0.0449788169178995 0.813059139594354 0.977383317127464 0.0687364183511213 "HRAS MUT" "Doxorubicin_IC_50" 0.479424792091836 0.836304203722611 0.61931663461538 0.879872336076338 0.989388044941135 0.0827111138685505 0.299143091822989 0.894167310052 0.86589884884302 "CDH1 MUT" "KIN001.135_IC_50" 0.883758946813233 0.9740212467918 0.0512445578231298 0.879886977956093 0.989388044941135 -0.0531327167360093 0.673138520407608 0.960256725054738 0.142188156147864 "CDH1 MUT" "Lenalidomide_IC_50" 0.889426145436693 0.975545707993487 -0.052578358925143 0.880100035716716 0.989388044941135 -0.0507719894679563 0.577325516459053 0.949294892873838 -0.217208233419498 "MYC MUT" "ATRA_IC_50" 0.574845490851034 0.872620551543038 -0.157353306261003 0.880116338427924 0.989388044941135 -0.0334679000051277 0.700887199344225 0.961100601384891 -0.0988492214585983 "BRAF MUT" "BI.2536_IC_50" 0.719887424760525 0.922157827678959 -0.184098279503107 0.880158601342182 0.989388044941135 0.0495238403125982 0.793545331311015 0.975393509832241 -0.179576534081704 "FGFR2 MUT" "CGP.082996_IC_50" 0.0513695576284562 0.404179538875753 1.84348233219567 0.880192798935567 0.989388044941135 0.123684955522414 0.174625446026403 0.84578207413725 1.55138925955179 "SOCS1 MUT" "AZD.2281_IC_50" 0.647061954658709 0.897186614618066 -0.485690344488178 0.880211118464127 0.989388044941135 -0.12089852279406 0.936816016061398 0.994831655017307 0.0738343862210496 "EGFR MUT" "KU.55933_IC_50" 0.502528389591996 0.846565396668817 -0.187522540983605 0.880553268019758 0.989546973269919 0.0375139252443958 0.51282838332081 0.939635632721979 -0.189767152382076 "FAM123B MUT" "Mitomycin.C_IC_50" 0.405362491330491 0.807904911469051 0.827959746503507 0.880575355224881 0.989546973269919 -0.116655383116376 0.454755849520837 0.925809648901546 0.733183514503412 "KDR MUT" "Vorinostat_IC_50" 0.885864033063095 0.974449243426767 0.105210477317554 0.880739395547379 0.989568211428536 0.083934198724419 0.736614132550266 0.96672489654949 -0.227192964726653 "ALK MUT" "BIRB.0796_IC_50" 0.60090862096041 0.880741900288913 -0.368238613231557 0.880817105206911 0.989568211428536 0.101360780144352 0.868981511306462 0.98751437004641 0.141370625516097 "RUNX1 MUT" "SL.0101.1_IC_50" 0.850176679993433 0.963526482778845 -0.133104294871793 0.880977475771065 0.989623192805821 -0.0916897725472059 0.701741136587459 0.961308504401238 -0.257223104560326 "FBXW7 MUT" "MG.132_IC_50" 0.961187375014705 0.993899806776065 -0.0370116687499991 0.881596025184731 0.989725913279421 0.10169468966108 0.573179848010147 0.949294892873838 -0.4120145401792 "SMARCA4 MUT" "Docetaxel_IC_50" 0.941801731742487 0.989446598697723 -0.0421348078431365 0.881737107777047 0.989725913279421 -0.0639913820872031 0.967756905749488 0.997173634484198 -0.0256621630095199 "STK11 MUT" "CI.1040_IC_50" 0.570141916225773 0.872389778906173 0.221128493686871 0.88183354524367 0.989725913279421 -0.0518408042684264 0.39694802322331 0.916480913435499 0.310806804665817 "VHL MUT" "Obatoclax.Mesylate_IC_50" 0.978000520158842 0.996276778834563 0.022612521089631 0.881864674878964 0.989725913279421 0.090124517182567 0.925368090254155 0.994026707431102 -0.0798723055739442 "SOCS1 MUT" "ZM.447439_IC_50" 0.464383213499366 0.829490249358073 -0.828254287109366 0.881915152988147 0.989725913279421 -0.133947996660966 0.705121899165471 0.962630898212352 -0.404172860822475 "GNAS MUT" "Parthenolide_IC_50" 0.834122023199512 0.959122768755193 -0.168068542372882 0.882056519280318 0.989725913279421 -0.110041986427349 0.707482007466715 0.962630898212352 -0.318176895533595 "MLH1 MUT" "Embelin_IC_50" 0.718258883953767 0.92132587844031 -0.150673601769913 0.88211503873697 0.989725913279421 0.0502022516903503 0.902555895134294 0.988746233284632 -0.0509204665059624 "JAK2 MUT" "AZD6244_IC_50" 0.699336482669752 0.914968665673257 0.388935153526961 0.882142757168177 0.989725913279421 -0.135280202278105 0.412408946931324 0.921714070263062 -0.827482189066869 "KDM5C MUT" "PLX4720_IC_50" 0.739043533447058 0.929570057037101 0.364587429118776 0.882410665295066 0.989725913279421 0.143456208651737 0.711152215240193 0.962630898212352 0.365081316292652 "FBXW7 MUT" "AP.24534_IC_50" 0.380132539896328 0.797344611908192 -0.527822847727266 0.882455306851985 0.989725913279421 -0.080436409461782 0.77865017649234 0.972337708041191 -0.165313856420245 "CDK4 MUT" "VX.680_IC_50" 0.76432023904144 0.936395094899577 -0.559237180272109 0.882499288920888 0.989725913279421 -0.181008228359789 0.541743048419425 0.945765861891114 -1.18148375196621 "FGFR3 MUT" "Vorinostat_IC_50" 0.995803513381043 0.998977896287767 -0.004716905511811 0.882901352453248 0.989725913279421 -0.100796127417809 0.578471133068245 0.949294892873838 -0.45281341747391 "MSH2 MUT" "VX.680_IC_50" 0.998902619986635 0.999548905963057 0.00163100000000009 0.882934055499513 0.989725913279421 0.114168219206938 0.726108999829041 0.965402608571648 0.435013078891551 "BCR_ABL MUT" "GW.441756_IC_50" 0.64486694187971 0.896610607131532 -0.281358102857146 0.88303434714284 0.989725913279421 0.0908608728274263 0.73664399239417 0.96672489654949 -0.20970004001662 "STK11 MUT" "Embelin_IC_50" 0.600819322883155 0.880741900288913 0.156168223327307 0.883232975624978 0.989725913279421 -0.0349671742415938 0.617392215331202 0.950247055931602 0.156948937013144 "GNAS MUT" "Roscovitine_IC_50" 0.949006642991856 0.991311220467028 -0.0538524305555562 0.88324525313276 0.989725913279421 0.10910767188732 0.696306666505588 0.961100601384891 0.338029404475112 "CDK4 MUT" "BX.795_IC_50" 0.219805051210898 0.692721312918376 0.625760930041155 0.883326004998562 0.989725913279421 0.057945473683794 0.189557071515741 0.851001889249827 0.617383454845671 "SETD2 MUT" "PD.0325901_IC_50" 0.83884365048811 0.959212868273494 -0.323722300990103 0.883465979144403 0.989725913279421 -0.222018887328634 0.80784276013791 0.977383317127464 0.33899817712599 "NF1 MUT" "FH535_IC_50" 0.305017330539237 0.754224310561809 0.34686787482342 0.883487948737124 0.989725913279421 0.0428133978027059 0.654965731012109 0.958313128388245 0.156609960262148 "CDKN2C MUT" "MK.2206_IC_50" 0.892963421282863 0.975972789421281 0.0856435349686849 0.883517957610101 0.989725913279421 -0.0748278477650348 0.695664961886006 0.961100601384891 0.260387215532719 "KDM6A MUT" "AZD6244_IC_50" 0.169897286067225 0.649721929411943 -0.737847941009245 0.883626410237358 0.989725913279421 0.0724338862830489 0.607707306439594 0.949657634568742 -0.254908346147504 "BRCA2 MUT" "Dasatinib_IC_50" 0.325136798496196 0.766576072987359 2.72740812925171 0.883628194966808 0.989725913279421 -0.337550689806544 0.361331586937994 0.91161229252998 2.23241295909418 "CDH1 MUT" "Methotrexate_IC_50" 0.315058604353136 0.760537253034044 0.913720767676763 0.883632109716533 0.989725913279421 -0.102520935972603 0.999333384956784 0.999751228014461 0.000603507105788384 "NRAS MUT" "NVP.BEZ235_IC_50" 0.231499797838872 0.704757001699372 -0.342053499183339 0.88386719569769 0.989864383983757 -0.0312472637092553 0.123166364519714 0.81266009160444 -0.481404286389815 "PTEN MUT" "Bexarotene_IC_50" 0.973243706384599 0.995472410100622 0.00632801087996171 0.884081322698297 0.989877892042573 -0.0250611240143072 0.710988845949698 0.962630898212352 0.07230101022117 "RB1 MUT" "ATRA_IC_50" 0.133293705986684 0.599990574185375 -0.362872660943403 0.884192112348164 0.989877892042573 0.0285321596735402 0.190414654461383 0.851001889249827 -0.307700398289902 "CCND2 MUT" "Etoposide_IC_50" 0.664377700165103 0.903589924015879 0.615075364421406 0.884213637830619 0.989877892042573 0.133642008311204 0.924506825674636 0.994026707431102 0.155491322370424 "KDR MUT" "Vinorelbine_IC_50" 0.539570794829469 0.861547651912703 -0.718906796200341 0.884378295034546 0.989926300555436 0.125166944670772 0.597702927849775 0.949294892873838 -0.613925559422235 "TET2 MUT" "PD.0332991_IC_50" 0.323509795933881 0.765322958956319 -1.12639730234157 0.884479810258685 0.989926300555436 0.134136473204077 0.339598171858162 0.907039453844874 1.25336346854178 "CTNNB1 MUT" "Tipifarnib_IC_50" 0.257565528216285 0.721889937062894 -0.662734036773435 0.884667194329406 0.989965994091367 -0.0564171436195605 0.692834185782911 0.961100601384891 -0.255748052626892 "TSC1 MUT" "GW.441756_IC_50" 0.900620467377472 0.979412650587141 -0.107612483870967 0.884738215865689 0.989965994091367 0.122628376584962 0.920862156908513 0.993931766508607 0.0847768873646915 "KDR MUT" "Bleomycin_IC_50" 0.588781547513104 0.876506729771444 -1.03200426829267 0.885035098686827 0.990173433035741 0.225157790505125 0.739390466247582 0.96672489654949 -0.618287627378693 "KDM5C MUT" "ATRA_IC_50" 0.519500800636348 0.852599738673405 -0.787031860687022 0.885471392364042 0.990340235699522 -0.139571651413158 0.596112262876964 0.949294892873838 -0.563334292243947 "CTNNB1 MUT" "Sorafenib_IC_50" 0.989051952421995 0.998036562927507 -0.0104711305841925 0.885489210054631 0.990340235699522 0.103651690237864 0.86126545503813 0.985524480087535 0.152954745900343 "KDM6A MUT" "PF.02341066_IC_50" 0.380877495794047 0.797708787892259 -0.365986277288731 0.885518726685047 0.990340235699522 -0.0557674076691036 0.344077056588856 0.907558164409155 -0.421335556347481 "ALK MUT" "JNJ.26854165_IC_50" 0.351604263230877 0.784966682190403 -0.751653991031379 0.885745836810738 0.990469500971564 -0.108764037493444 0.434757981086794 0.922569292988365 -0.605778881666554 "TET2 MUT" "Gefitinib_IC_50" 0.0958308881723793 0.529259917882996 -1.56361261026614 0.886017497298255 0.990648545071862 -0.122972999866233 0.737369602657177 0.96672489654949 0.349389445109614 "MLLT3 MUT" "FH535_IC_50" 0.626849625154001 0.89123540333742 -0.171806644655705 0.886395412995179 0.990831778717778 0.0430290699095338 0.984764607571757 0.998124818853736 -0.00674977716351617 "CDKN2C MUT" "Dasatinib_IC_50" 0.86278074540514 0.966980792521839 -0.27872003448276 0.886627896995723 0.990831778717778 0.189636607001207 0.669423468148581 0.959230524020512 0.72787457658047 "TET2 MUT" "WH.4.023_IC_50" 0.995899210256252 0.998977896287767 0.0105914653014785 0.886713472874717 0.990831778717778 -0.257786017391953 0.797885737366869 0.976360691959787 -0.601084352177345 "FLCN MUT" "Bleomycin_IC_50" 0.28104694359262 0.738018304567137 1.59617107692307 0.886741659391056 0.990831778717778 -0.171853113475784 0.75369659360154 0.96913420088708 -0.575647241957224 "MAP2K4 MUT" "BMS.536924_IC_50" 0.821378711561955 0.956293356389236 -0.323829925170068 0.886884304766436 0.990831778717778 -0.150650833391698 0.975111016522049 0.99742775226181 0.0516932390824759 "PTEN MUT" "KIN001.135_IC_50" 0.870109056933374 0.969565688158757 -0.0198537551020409 0.887132148021638 0.990831778717778 -0.0171348538955911 0.479088428349799 0.930304161706959 0.0883213943545433 "MYC MUT" "WH.4.023_IC_50" 0.36287970378948 0.787293170741334 0.687566051470585 0.887384973096872 0.990831778717778 0.0957829100260161 0.893291766807573 0.988301482344111 -0.100511438187852 "NF1 MUT" "SB.216763_IC_50" 0.516115092923554 0.852353345422823 0.210506941391943 0.887540996761779 0.990831778717778 0.0443964221093858 0.555527813583882 0.948071221654821 0.19666968497086 "CDKN2A MUT" "GW843682X_IC_50" 0.0664507999714576 0.458546662429304 -0.538373435185183 0.88759383009063 0.990831778717778 -0.0227602144266963 0.36982217123074 0.913948248824328 -0.316301557883755 "IDH1 MUT" "Bexarotene_IC_50" 0.900671446610199 0.979412650587141 -0.142004053913045 0.887633091176654 0.990831778717778 0.142475857860197 0.524941364080956 0.940554660491705 0.694973077726862 "CDK4 MUT" "BMS.509744_IC_50" 0.300745078291672 0.751119785777076 -1.2707012881356 0.887920652789659 0.990831778717778 -0.129151544371333 0.343378860910477 0.907180409180092 -1.14944534201019 "FGFR3 MUT" "Cytarabine_IC_50" 0.952922437199257 0.992561499112566 -0.0829809943073999 0.887947008594585 0.990831778717778 -0.14994436123773 0.895903470564148 0.988301482344111 -0.169742397998365 "MLL_AFF1 MUT" "GSK.650394_IC_50" 0.125657111818918 0.586978030371663 -2.25530812521742 0.888218813751816 0.990831778717778 0.136053828040199 0.153991962976897 0.835611501078903 -2.1036308500502 "NOTCH1 MUT" "NSC.87877_IC_50" 0.787650247524174 0.946449577332088 0.0764410998233207 0.888269592207582 0.990831778717778 -0.0403351546482305 0.742814244059743 0.966725278648091 -0.10415680929978 "CTNNB1 MUT" "Thapsigargin_IC_50" 0.205924203026738 0.679098717816733 -0.95158492455517 0.888486843028657 0.990831778717778 -0.0804075259659306 0.485013964664608 0.933639405738697 -0.573718067032343 "MYCL1 MUT" "Mitomycin.C_IC_50" 0.826604515124542 0.957600463040636 -0.154851787830689 0.888689867944074 0.990831778717778 0.0774631171123022 0.485689796679472 0.933639405738697 -0.523187254696661 "VHL MUT" "CMK_IC_50" 0.844158213977708 0.960498931426639 0.151431835051547 0.888841199211303 0.990831778717778 -0.101076289858337 0.267359117525048 0.877052916121269 1.0222126332907 "EP300 MUT" "Lenalidomide_IC_50" 0.587894460380444 0.876506729771444 0.333013656527245 0.889417996942252 0.990831778717778 -0.0753401982905814 0.766755811722588 0.969901216545994 0.173769177114277 "NF1 MUT" "JNK.9L_IC_50" 0.2152223318405 0.688608753079032 0.369733095779216 0.889637953391888 0.990831778717778 0.0325914761245133 0.808871366182806 0.977383317127464 -0.0774920962699329 "CDK4 MUT" "AUY922_IC_50" 0.584911877499415 0.876506729771444 -0.368198550527243 0.889649177545794 0.990831778717778 -0.0631710760099738 0.769975052883146 0.969901216545994 -0.199898483313028 "TSC1 MUT" "FTI.277_IC_50" 0.361633889015012 0.787174158907433 0.711780044827596 0.889824299549253 0.990831778717778 0.0984923081387046 0.463452031192668 0.929276781658587 0.541573742331317 "KDM6A MUT" "GDC0941_IC_50" 0.369564170496246 0.789535578103719 -0.414091423097253 0.889863254322056 0.990831778717778 0.0517634276455399 0.498310447479291 0.934042323734638 -0.321076237088077 "MAP2K4 MUT" "A.770041_IC_50" 0.808751342871854 0.952641225877339 -0.359150363945578 0.889863829631631 0.990831778717778 -0.167243332863669 0.800889750988844 0.976360691959787 -0.433016625278162 "KDR MUT" "RO.3306_IC_50" 0.909901229713958 0.981755900994977 -0.0963122504892362 0.889899081754256 0.990831778717778 0.112317494025909 0.889445603255955 0.988301482344111 -0.119478090872167 "CCND3 MUT" "Nilotinib_IC_50" 0.550729748561987 0.865580796066258 0.692468032258057 0.890041411438706 0.990831778717778 -0.129864539037034 0.48752291446279 0.933639405738697 0.72102955988234 "SMO MUT" "Doxorubicin_IC_50" 0.528631165457492 0.855149978220034 -0.870190318260873 0.890064504122823 0.990831778717778 0.118366581214887 0.363366211786616 0.912304381946028 -1.18953444352517 "MLL_AFF1 MUT" "GDC.0449_IC_50" 0.128574266009212 0.58914788070103 -1.31420681467181 0.89031777921543 0.990831778717778 0.108400123060669 0.442519772067906 0.925132196705984 -0.667813045002754 "MDM2 MUT" "NVP.BEZ235_IC_50" 0.134570304875325 0.601893367640051 0.775778557795699 0.890409086941295 0.990831778717778 0.0516218794086523 0.0951418924204526 0.77097828178369 0.816524792284704 "TET2 MUT" "AZD6482_IC_50" 0.979674035532287 0.996276778834563 0.0289988825561312 0.890580977290156 0.990831778717778 0.133819055371134 0.850793800086003 0.984453468864253 -0.256266057120115 "MS-HL MUT" "SB590885_IC_50" 0.728343253323966 0.926426027496487 -0.0870416215596335 0.890640292356278 0.990831778717778 -0.0288389315718244 0.668059607308099 0.959230524020512 0.102960174312544 "CDK4 MUT" "BAY.61.3606_IC_50" 0.754607407887674 0.933900277236682 0.212724894991215 0.890911052055933 0.990831778717778 0.0651747784346527 0.800519041137179 0.976360691959787 0.171386829675953 "MLLT3 MUT" "Shikonin_IC_50" 0.44496870018403 0.825606373270691 -0.339525716883117 0.890967496030594 0.990831778717778 -0.0510243092873191 0.766766324757284 0.969901216545994 -0.134098649770614 "CDK4 MUT" "Z.LLNle.CHO_IC_50" 0.483087729586327 0.839032590911741 -0.903047778911565 0.891115295956321 0.990831778717778 -0.163794812492103 0.859200634875669 0.985478604976213 -0.22373338808324 "PIK3R1 MUT" "BMS.536924_IC_50" 0.213065964510326 0.687763182315503 1.38638455821917 0.891170503227845 0.990831778717778 -0.112513985063312 0.188673671879388 0.851001889249827 1.37495689149951 "BRCA2 MUT" "AS601245_IC_50" 0.676151505787547 0.908661532914054 0.308779873905431 0.891224687646794 0.990831778717778 -0.0814603735983897 0.800032594523044 0.976360691959787 0.186928694949209 "MAP2K4 MUT" "BIRB.0796_IC_50" 0.612462125458107 0.88496040166963 0.179852944983817 0.891311617721207 0.990831778717778 0.0463922564131176 0.963112649530748 0.997016370262569 -0.0179799830905272 "SMAD4 MUT" "Cyclopamine_IC_50" 0.851229283168035 0.963639744191413 -0.106064808362369 0.891493970266037 0.990831778717778 0.0733769592049558 0.517710981077333 0.939635632721979 -0.388424506090063 "IDH1 MUT" "CHIR.99021_IC_50" 0.927803401044482 0.986593180452362 0.0920850517241384 0.891544171961003 0.990831778717778 0.130678703626056 0.670283261950527 0.95927684711462 0.420111631048278 "KRAS MUT" "AZD.2281_IC_50" 0.0127339179153651 0.203765630642086 0.450534639989641 0.891724118712456 0.990831778717778 0.0197994938946858 0.800988431413554 0.976360691959787 0.0468483830309382 "KRAS MUT" "PD.173074_IC_50" 0.00346476621595665 0.0955608346705312 0.502674028457215 0.891759071472613 0.990831778717778 0.0212693627933601 0.348327575066454 0.909999728614578 0.174196878467129 "NF1 MUT" "NU.7441_IC_50" 0.324071432482927 0.765579672794663 0.300926249060653 0.891900942942656 0.990831778717778 0.0365707879268355 0.522466002142946 0.940036581246253 0.203886827840293 "GNAS MUT" "BMS.708163_IC_50" 0.777205623523899 0.941790749776385 0.11564381632653 0.89212968055026 0.990831778717778 0.0557791038248888 0.992658381445514 0.999469155159075 -0.003816053517864 "EP300 MUT" "MS.275_IC_50" 0.660017653674468 0.902400992643984 -0.684559856655296 0.892340480568872 0.990831778717778 0.174819209015987 0.563127591005344 0.949294892873838 -0.934911322581537 "SMO MUT" "ATRA_IC_50" 0.940849378258285 0.989446598697723 -0.0906841507633603 0.892508244263736 0.990831778717778 -0.129443165465668 0.643853683283494 0.956058737832946 -0.493264281333725 "CCND3 MUT" "AP.24534_IC_50" 0.652476215014437 0.899928756878897 0.625330294117662 0.892769948945104 0.990831778717778 -0.168948128209567 0.456146090797516 0.925809648901546 0.973633006616891 "CDK4 MUT" "CMK_IC_50" 0.519027369330057 0.852599738673405 -0.781164272108844 0.892924458908301 0.990831778717778 -0.148946477554808 0.80102854663469 0.976360691959787 -0.314439466370543 "MYCL1 MUT" "AZD6244_IC_50" 0.565586791724698 0.872195918962848 0.489984883333337 0.893087896773684 0.990831778717778 0.103904187861846 0.850879948992457 0.984453468864253 -0.157627855124482 "FAM123B MUT" "CCT007093_IC_50" 0.883477254237996 0.973927829424842 0.0744810538116589 0.893119458721862 0.990831778717778 -0.0684652342568286 0.818382004682199 0.977383317127464 -0.119898972766022 "KIT MUT" "Salubrinal_IC_50" 0.552866071533026 0.866603215811789 -0.724044027303761 0.893375288290301 0.990831778717778 -0.13931744345412 0.840534380675274 0.982150602679453 -0.246098957594269 "AKT2 MUT" "Docetaxel_IC_50" 0.564523073092276 0.871766547058339 0.467884365048547 0.893389114282452 0.990831778717778 0.0817904691974509 0.338376524454967 0.906340202363472 0.75646839495476 "FGFR3 MUT" "Dasatinib_IC_50" 0.305296153400673 0.754224310561809 -2.84136874149661 0.893403422457242 0.990831778717778 0.305184381321027 0.225844829317259 0.86643108387559 -2.9255625325282 "CCND1 MUT" "Elesclomol_IC_50" 0.651300601404177 0.899243470992269 0.201696308333335 0.893682105578076 0.990831778717778 0.0498224358237427 0.536821456487911 0.943443271455699 0.280824477499461 "RUNX1 MUT" "PLX4720_IC_50" 0.948277307673448 0.990899019819731 -0.0710016513409964 0.89370330393986 0.990831778717778 -0.12938645332198 0.810393419732522 0.977383317127464 -0.236141676936894 "NF2 MUT" "AZD.0530_IC_50" 0.0844617583111369 0.501742391679737 -1.11933093425604 0.893888259301816 0.990831778717778 -0.0764276309412396 0.325665063941147 0.900918773778407 0.659004632280312 "KRAS MUT" "NVP.BEZ235_IC_50" 0.000972959014783131 0.0445762092657074 0.607852683263859 0.894090253619092 0.990831778717778 -0.0189686027952676 0.191400228520967 0.851001889249827 0.269746212284154 "EWS_FLI1 MUT" "Shikonin_IC_50" 0.392837124382397 0.803073858340542 -0.457109779188705 0.89411543011876 0.990831778717778 0.0642658175042458 0.886928703733963 0.988301482344111 0.0846768370835873 "RUNX1 MUT" "LFM.A13_IC_50" 0.590804920454589 0.876991017840199 0.267063461538464 0.894295787523481 0.990831778717778 0.0619807658574242 0.974445498953309 0.99742775226181 0.0176008661907936 "CDKN2a(p14) MUT" "CEP.701_IC_50" 0.00311907437602488 0.0890691303327233 -0.486418269643021 0.89434784954558 0.990831778717778 0.0165211845568466 0.400502113219261 0.916589616820582 -0.140590995720376 "FGFR3 MUT" "AICAR_IC_50" 0.823811439433448 0.957177484110155 -0.270518471953574 0.894764114046949 0.990831778717778 -0.143676547786701 0.764084743228666 0.969901216545994 -0.349105177064999 "SMO MUT" "Embelin_IC_50" 0.520814500878642 0.852599738673405 -0.651021582608699 0.894775032748042 0.990831778717778 0.106710165436187 0.414245734291771 0.92211126027385 -0.815198091574328 "NF1 MUT" "JNJ.26854165_IC_50" 0.662734749702894 0.903526384925934 0.106355290025576 0.894853851053362 0.990831778717778 0.0301490325020129 0.826866281856097 0.980698467734194 0.0536466124012607 "MDM2 MUT" "TW.37_IC_50" 0.37103193778051 0.790579328077906 0.385875820091322 0.894964015667488 0.990831778717778 -0.0516234725695154 0.190773022732897 0.851001889249827 0.538276015818678 "MS-HL MUT" "X17.AAG_IC_50" 0.776804880963002 0.941687707866833 0.0835421508962772 0.894995262530955 0.990831778717778 0.0342529823212435 0.101868663529379 0.775231877295988 -0.463426836596208 "BRCA2 MUT" "GSK269962A_IC_50" 0.523639645710964 0.854075976778526 1.04570183050847 0.895155593054006 0.990831778717778 -0.202749437855755 0.857863704437479 0.984898622336936 -0.296824659833042 "TSC1 MUT" "Cisplatin_IC_50" 0.960218141327916 0.99365707033384 -0.0585964459203022 0.895257808131459 0.990831778717778 0.13431706712712 0.923315652512922 0.993931766508607 0.108164879146963 "MLH1 MUT" "Elesclomol_IC_50" 0.259045504836552 0.723189643810247 0.748625259915756 0.895262408619952 0.990831778717778 0.0736543080237276 0.316050238395777 0.900294798053993 0.633729908078447 "SETD2 MUT" "NVP.BEZ235_IC_50" 0.662652712848463 0.903526384925934 -0.476933711729611 0.895311437374814 0.990831778717778 0.104608270127042 0.961089701211374 0.996625877572729 -0.0506715378367661 "TSC1 MUT" "AZD7762_IC_50" 0.709939520173177 0.91855665481614 -0.47094261714287 0.895348298009979 0.990831778717778 0.130306497298657 0.691047010486293 0.961100601384891 0.457361235813283 "NF1 MUT" "Imatinib_IC_50" 0.497628114462431 0.844923707565453 0.277843559814169 0.895463530818713 0.990831778717778 0.053580165277201 0.436453082561002 0.922569292988365 0.388704450970978 "CDKN2a(p14) MUT" "AZD8055_IC_50" 0.0579221098076527 0.43286323628399 -0.245785138196759 0.895667204636848 0.990831778717778 -0.013821954386213 0.563200216565534 0.949294892873838 -0.0814850301688236 "NF2 MUT" "BI.2536_IC_50" 0.611530220304482 0.88496040166963 -0.370487681184671 0.896145431785036 0.990831778717778 0.058299446583935 0.881687413322348 0.988301482344111 -0.12332366745634 "FGFR2 MUT" "Temsirolimus_IC_50" 0.712787785716804 0.919646314953749 0.594727521821629 0.896178532534573 0.990831778717778 0.162156107341285 0.881982450504785 0.988301482344111 0.321191259423894 "SMO MUT" "Epothilone.B_IC_50" 0.424144587634514 0.81834196888597 -1.32112770086957 0.896187757965453 0.990831778717778 0.12233190763563 0.380902301046448 0.915134825237766 -1.40674242651261 "EWS_FLI1 MUT" "JNK.9L_IC_50" 0.195479146367492 0.671326488356419 -0.464791016225745 0.896293878750172 0.990831778717778 0.0386020904104157 0.705973346871874 0.962630898212352 -0.153356370057873 "KRAS MUT" "Nutlin.3a_IC_50" 0.654870801367853 0.901074441039429 0.0999698604534145 0.896395272875091 0.990831778717778 -0.028348900865575 0.983222161239284 0.998011368051263 0.00532660272359748 "EGFR MUT" "CMK_IC_50" 0.680759706019566 0.909596174888715 0.226035188811187 0.896472853330111 0.990831778717778 -0.0647983579655082 0.453582558272964 0.925809648901546 0.425954315779088 "MET MUT" "PF.4708671_IC_50" 0.935588516295751 0.988214667968534 -0.028988964010818 0.8965012599717 0.990831778717778 0.046209132714183 0.840519922817621 0.982150602679453 -0.0729412864439333 "FLT3 MUT" "Doxorubicin_IC_50" 0.193882379263704 0.669007940801379 -1.27020463874348 0.896581617080782 0.990831778717778 0.0804297458425906 0.363096707907014 0.912280009424634 -0.852447894029512 "MDM2 MUT" "BIRB.0796_IC_50" 0.762453566657473 0.936064732612588 0.11734087040619 0.896627400861723 0.990831778717778 -0.0483139911239402 0.813349205349632 0.977383317127464 0.0901491084902442 "FBXW7 MUT" "Doxorubicin_IC_50" 0.300564143763981 0.751119785777076 -0.438636691728088 0.89665031247676 0.990831778717778 -0.0346107929101089 0.59029270714443 0.949294892873838 -0.2259842727711 "CDK4 MUT" "NU.7441_IC_50" 0.35240118701167 0.784969887597353 0.424754945891782 0.897231422706605 0.990831778717778 -0.0519199534954897 0.440876981230606 0.924472815010418 0.35529486504121 "CDK4 MUT" "KU.55933_IC_50" 0.293297718691567 0.747036827777118 0.421056372745489 0.897260040012273 0.990831778717778 0.0461278154486053 0.418840695990675 0.922428741067589 0.334550168899096 "HRAS MUT" "IPA.3_IC_50" 0.499365790964014 0.845109283443017 0.626170185314679 0.897443003374164 0.990831778717778 -0.100805651068084 0.691686667309325 0.961100601384891 0.341953269764413 "MLH1 MUT" "GSK.650394_IC_50" 0.735635970110992 0.928872455997232 -0.204978755752213 0.897728355527339 0.990831778717778 0.0509455421764602 0.910768292843045 0.990141873133243 -0.0681920329294236 "MLLT3 MUT" "Bosutinib_IC_50" 0.663782647043348 0.903538553756266 -0.182538602465809 0.89791609055616 0.990831778717778 -0.0441809392729966 0.306136474798944 0.896682870760742 -0.416547613261832 "KRAS MUT" "MK.2206_IC_50" 0.000320863971620279 0.0221474759229601 0.796765132923546 0.898089664718523 0.990831778717778 -0.0246940645370016 0.00820026080284154 0.397959104863583 0.679271444253831 "SETD2 MUT" "Etoposide_IC_50" 0.2767351187859 0.735108059249974 1.88602940689659 0.89837540620022 0.990831778717778 -0.145763882846239 0.32237666971555 0.900918773778407 1.62678835598628 "EGFR MUT" "ATRA_IC_50" 0.939130117239654 0.989255672068006 -0.02808864162849 0.898383692114219 0.990831778717778 -0.0371383713145472 0.252311178434981 0.875707386589409 -0.386484527415453 "CCND1 MUT" "IPA.3_IC_50" 0.167466406339959 0.647446641789 0.561206546936023 0.89853374270543 0.990831778717778 0.0439146944787379 0.980153661640238 0.997827228172038 0.0100879207239632 "MYC MUT" "RDEA119_IC_50" 0.669285110339514 0.906776668943588 0.164585432012847 0.898535548678985 0.990831778717778 -0.0446156621847724 0.4412768914883 0.924472815010418 -0.265509065557844 "RB1 MUT" "AP.24534_IC_50" 0.541141132020605 0.861616652986104 0.216853392490891 0.898580652027135 0.990831778717778 -0.0417672153637486 0.573311070911207 0.949294892873838 -0.214393900489574 "MSH6 MUT" "Salubrinal_IC_50" 0.594233819302364 0.878468193610776 -0.461163316151203 0.898613014681157 0.990831778717778 0.0909753719825084 0.563710956127191 0.949294892873838 -0.493332805572674 "BCR_ABL MUT" "AUY922_IC_50" 0.497997882381377 0.844997935313146 0.643688517452016 0.898647068832886 0.990831778717778 0.0972270914080234 0.271987136022822 0.880932806352548 1.01620343209902 "CDKN2C MUT" "CMK_IC_50" 0.920705973378692 0.986016435821543 -0.0701242390804602 0.898853075060051 0.990831778717778 0.0823367681843973 0.951438266640809 0.995669074626174 -0.0533659071376498 "MYCL1 MUT" "Etoposide_IC_50" 0.977392460162663 0.996276778834563 0.0221396118881119 0.898893539164528 0.990831778717778 -0.0646650530948931 0.485552266285706 0.933639405738697 -0.563544200857212 "VHL MUT" "Nutlin.3a_IC_50" 0.994753388764098 0.998977896287767 0.00437217588933007 0.899112939806346 0.990831778717778 0.0776015077396634 0.832259253708221 0.981482581683432 -0.147856240586099 "CDH1 MUT" "CGP.082996_IC_50" 0.605926368697861 0.882603260686518 -0.380536254295534 0.899133652963486 0.990831778717778 0.0806040289666324 0.846135405218746 0.98378870157398 -0.145150299357855 "FGFR3 MUT" "Bosutinib_IC_50" 0.98394091825293 0.996723172778267 -0.0256289885714295 0.899904617677825 0.990831778717778 0.131336121878811 0.837004635751064 0.981704379975756 -0.241677719635856 "BRCA1 MUT" "Embelin_IC_50" 0.45263416210137 0.828509891052426 0.539348979057601 0.899913527116809 0.990831778717778 0.0722100556064222 0.530255478862463 0.94320946427311 0.449171382718733 "SMO MUT" "Axitinib_IC_50" 0.758535985327266 0.934762260113025 0.387278466793167 0.900109737268906 0.990831778717778 -0.132933512333638 0.751692302293648 0.968780465757047 -0.348664936112457 "MLL_AFF1 MUT" "Lenalidomide_IC_50" 0.103159343787113 0.54436014983562 -1.22408614800758 0.900279479487816 0.990831778717778 0.0841393573427901 0.714616892207704 0.962630898212352 -0.266705522487364 "CDK4 MUT" "Obatoclax.Mesylate_IC_50" 0.923648169491007 0.98643792569589 -0.078589374780317 0.900359826032496 0.990831778717778 0.0757864988787144 0.994840101544802 0.999545005862799 0.00539948125625266 "TET2 MUT" "GW.441756_IC_50" 0.909230624120041 0.981529929795606 -0.0802943200253457 0.900369087906834 0.990831778717778 0.0872500753517546 0.799214837485337 0.976360691959787 -0.218517952699714 "SMARCA4 MUT" "RDEA119_IC_50" 0.874663387660763 0.971349949457951 -0.117845225352113 0.900395698579608 0.990831778717778 -0.0841732906197204 0.749945305774855 0.968780465757047 -0.232586542200801 "CDK6 MUT" "KU.55933_IC_50" 0.766101236088651 0.937321153907337 0.133055389221557 0.90053781131324 0.990831778717778 0.04956142737593 0.752210543750783 0.968780465757047 0.1387695139054 "NF1 MUT" "PF.02341066_IC_50" 0.324453906209102 0.765831726397406 0.471811774305556 0.900544947160624 0.990831778717778 0.0557883352219544 0.482319675075685 0.931217392063982 0.380910154261214 "MDM2 MUT" "JW.7.52.1_IC_50" 0.374337674434783 0.794193236181393 -1.07717906164384 0.900583053138275 0.990831778717778 -0.0918170138422692 0.601372189045771 0.949657634568742 -0.644059937318232 "BCR_ABL MUT" "BIBW2992_IC_50" 0.321958696239455 0.762687431662469 -0.942366123809537 0.900699761317165 0.990831778717778 -0.139385704181543 0.386844133959684 0.915662729926209 -0.783413667751315 "MDM2 MUT" "Vorinostat_IC_50" 0.135079123666608 0.602530234697714 0.603464224000001 0.900863779910466 0.990831778717778 0.0384391356251358 0.205952305596545 0.853446327418758 0.463115742319305 "BRCA1 MUT" "Bortezomib_IC_50" 0.666623848498654 0.905242568580512 -0.688106445578233 0.90088323391726 0.990831778717778 -0.161619644682703 0.852421318745587 0.984631915507353 -0.286275561591258 "ALK MUT" "Erlotinib_IC_50" 0.82314338588885 0.957106429492329 0.272749745454546 0.900985976639598 0.990831778717778 -0.13811828918692 0.798631418687318 0.976360691959787 -0.305390856156236 "CDKN2a(p14) MUT" "Roscovitine_IC_50" 0.286405634962834 0.741305709900881 -0.223739568811802 0.901003326336984 0.990831778717778 -0.0248385624532903 0.674719675961945 0.960256725054738 -0.100439817121233 "GNAS MUT" "GSK269962A_IC_50" 0.942483102782204 0.989852464026579 0.0839659215017069 0.901108011628421 0.990831778717778 0.134970861373817 0.632069842416326 0.952523560833852 -0.570655539974089 "STK11 MUT" "GDC.0449_IC_50" 0.64944930365436 0.898715072993842 0.12098933369843 0.901138632300513 0.990831778717778 -0.0294702297336607 0.832198438762986 0.981482581683432 -0.0597280932434655 "FGFR2 MUT" "PF.562271_IC_50" 0.0187542461074403 0.24981411768757 1.80558458304497 0.901142555305087 0.990831778717778 -0.0790616354321019 0.284666807489064 0.8879937007725 0.932103233911648 "FGFR3 MUT" "GDC0941_IC_50" 0.771024322463367 0.939898671414565 -0.374525094455863 0.901380279958539 0.990831778717778 0.128299907459527 0.706483122169631 0.962630898212352 -0.479660473727172 "ERBB2 MUT" "Bexarotene_IC_50" 0.486346708846478 0.84074437879216 0.275215650210083 0.901447129592447 0.990831778717778 0.044902893156155 0.818562138869675 0.977383317127464 0.0918845830519958 "CTNNB1 MUT" "BIBW2992_IC_50" 0.941705679562454 0.989446598697723 0.0389474068276682 0.901472409308348 0.990831778717778 0.0634924705021162 0.987088416003025 0.998124818853736 -0.0086950067758808 "NRAS MUT" "AZD.2281_IC_50" 0.247948469767727 0.714944922080254 -0.302814184962405 0.901601931277474 0.990831778717778 0.0255696933006756 0.652778294992549 0.958313128388245 -0.118584598054643 "MET MUT" "AMG.706_IC_50" 0.405288290195182 0.807904911469051 0.325166132297129 0.901773925435946 0.990831778717778 0.0445108996349089 0.821554822132582 0.97739893500462 0.0811703593330774 "STK11 MUT" "PLX4720_IC_50" 0.466914296600844 0.830828665219814 0.293178518447949 0.901907495877278 0.990831778717778 -0.0441037185269465 0.818596713952563 0.977383317127464 0.0894986314683346 "SMARCA4 MUT" "Vinblastine_IC_50" 0.95552200411669 0.992745778961198 0.0318112215799612 0.901992552056713 0.990831778717778 -0.0504804549062877 0.698365297681991 0.961100601384891 -0.236612574835757 "ALK MUT" "NU.7441_IC_50" 0.526967703268804 0.855121165130409 -0.524027851119896 0.902086872291098 0.990831778717778 0.0896253578702302 0.316182803190002 0.900294798053993 -0.985346633150456 "MLL_AFF1 MUT" "A.770041_IC_50" 0.506385881717332 0.847796212975596 -1.20514805762713 0.902158302942507 0.990831778717778 0.18564523946096 0.383359660402742 0.915134825237766 -1.50719808938894 "MET MUT" "BX.795_IC_50" 0.214666136982262 0.688117861819268 0.632782493827166 0.902213897476752 0.990831778717778 0.0485788691432175 0.685194418965322 0.961100601384891 0.181560132734033 "CDKN2A MUT" "VX.680_IC_50" 0.00591041633301962 0.13354970510576 -0.869977897690752 0.902335648234287 0.990831778717778 -0.0270223854742348 0.0567386820641588 0.697813103075383 -0.721926044456376 "TET2 MUT" "A.770041_IC_50" 0.941642895479882 0.989446598697723 0.1086313707483 0.902415951639392 0.990831778717778 -0.149412610305503 0.657124667478045 0.958313128388245 -0.762936153027515 "SMARCB1 MUT" "LFM.A13_IC_50" 0.594216640045658 0.878468193610776 -0.417297217391308 0.902428865900982 0.990831778717778 0.090185654816151 0.606745642937405 0.949657634568742 -0.406457968817526 "GNAS MUT" "Obatoclax.Mesylate_IC_50" 0.206509228044916 0.679262390469222 0.927490867724866 0.902541211679188 0.990831778717778 0.0660839998650678 0.581286750936205 0.949294892873838 0.391661861634144 "MLH1 MUT" "PLX4720_IC_50" 0.498512119273445 0.845109283443017 -0.389787448178284 0.902542174242638 0.990831778717778 0.063245810867696 0.759398418528919 0.969901216545994 -0.161537900710072 "EZH2 MUT" "WH.4.023_IC_50" 0.204065882187477 0.675781408528279 2.26738276027398 0.902616928503939 0.990831778717778 0.190724314787805 0.186300241621105 0.851001889249827 2.52610279378313 "MYCN MUT" "RDEA119_IC_50" 0.354170499839887 0.785252181551816 0.482843874191658 0.90267654433109 0.990831778717778 -0.0598037163688654 0.000995658337961654 0.160771667262499 -1.77335425855701 "RB1 MUT" "FTI.277_IC_50" 0.137018585817355 0.604353219297467 0.209905246037802 0.902720418820157 0.990831778717778 0.0161210914753007 0.723461828335024 0.965402608571648 0.0541347647380155 "MLH1 MUT" "AZ628_IC_50" 0.736073689470503 0.928872455997232 0.32595500347222 0.902745042281191 0.990831778717778 0.0888112982030429 0.0744792398624242 0.741811190933953 1.5058447513861 "MDM2 MUT" "SB590885_IC_50" 0.251742873431987 0.717470497840808 0.701273777093316 0.902764084802316 0.990831778717778 0.0625625494148947 0.374491349788507 0.913948248824328 0.472722361315481 "BRAF MUT" "Camptothecin_IC_50" 0.650918613481746 0.89914499319121 0.144825661871884 0.90276924505868 0.990831778717778 -0.0265570315407363 0.265007889183229 0.877052916121269 -0.375422119966547 "CCND1 MUT" "PLX4720_IC_50" 0.466522352378799 0.830828665219814 0.282016636000002 0.902772271969939 0.990831778717778 0.0423260051772069 0.778398346692064 0.972337708041191 0.106787028921397 "MDM2 MUT" "Vinblastine_IC_50" 0.212357278307324 0.686649630080219 0.710779154142584 0.902797619467014 0.990831778717778 0.0503343266846849 0.195686158990856 0.851001889249827 0.6883227746437 "EWS_FLI1 MUT" "WO2009093972_IC_50" 0.765252854253719 0.936968974174869 0.129602907437714 0.90283566160717 0.990831778717778 0.0532348152779673 0.665323003067987 0.959206771190239 0.240844184165147 "FAM123B MUT" "PF.4708671_IC_50" 0.952265709969248 0.992561499112566 -0.0353266891891897 0.902840868653708 0.990831778717778 -0.0711190040072726 0.940377817202665 0.995120990231635 0.0454624639070581 "PTEN MUT" "CI.1040_IC_50" 0.401529153260795 0.806415132522709 -0.187004558965261 0.902859052828203 0.990831778717778 -0.0249351504526939 0.0741877995319631 0.741621865836141 -0.380631174723932 "TP53 MUT" "PD.173074_IC_50" 0.330000686646942 0.771449354596339 0.131305458203329 0.902912261664451 0.990831778717778 -0.0147122346590191 0.769802559404257 0.969901216545994 -0.0390768640529117 "MYCN MUT" "AZD6482_IC_50" 0.161423835167525 0.636874757939932 0.641720081050767 0.902924900876517 0.990831778717778 0.0481637698041 0.829185865186151 0.981081757090089 -0.111586988833389 "EZH2 MUT" "WZ.1.84_IC_50" 0.193342540984773 0.668382680609485 1.09558636986302 0.902936583148777 0.990831778717778 -0.0858360389994833 0.42530425871533 0.922428741067589 0.732496418633394 "JAK2 MUT" "Docetaxel_IC_50" 0.608959808383796 0.884360685431551 0.351807055416315 0.903004218872997 0.990831778717778 0.0627571181358986 0.614875664554992 0.950059945073224 -0.363081003185329 "FGFR3 MUT" "KIN001.135_IC_50" 0.478484988146082 0.836304203722611 -0.390625252525248 0.903263018910743 0.990831778717778 -0.0654538809941858 0.790497814513435 0.975393509832241 -0.137688439228917 "KDR MUT" "BX.795_IC_50" 0.462738851180668 0.829373172137011 -0.679193912102766 0.903318924080122 0.990831778717778 0.0867218731921332 0.736135650180292 0.96672489654949 -0.27765590882031 "FLT3 MUT" "BI.2536_IC_50" 0.15236190578134 0.625830613280407 -1.88045332653063 0.903609263805117 0.990831778717778 0.0959097016793079 0.135343512033325 0.828937189282754 -2.0451555590704 "MYCL1 MUT" "BMS.536924_IC_50" 0.532103688686296 0.857771840823296 0.636756518900348 0.903685156412817 0.990831778717778 -0.0924149794087341 0.305466386439476 0.896453471410625 -1.0316175144297 "CCND1 MUT" "AUY922_IC_50" 0.573835300757922 0.872620551543038 0.209894145521883 0.90370729415614 0.990831778717778 -0.0305702504723918 0.699903398459375 0.961100601384891 0.147402370427596 "SMARCA4 MUT" "SB590885_IC_50" 0.691631698871093 0.912974964595134 0.242833074378279 0.90370910706814 0.990831778717778 -0.0615957996626001 0.51647970300411 0.939635632721979 -0.398796527790521 "KDM5C MUT" "PHA.665752_IC_50" 0.776543627028279 0.941591338606299 -0.195772533783786 0.903789041381895 0.990831778717778 -0.0833951430490024 0.691466165509238 0.961100601384891 -0.279220843130513 "HRAS MUT" "Bosutinib_IC_50" 0.74142465105058 0.929570057037101 -0.243483836852208 0.904011028151811 0.990831778717778 -0.0733407089127868 0.935936049573066 0.994729228933513 -0.0548755495603578 "SMARCB1 MUT" "Shikonin_IC_50" 0.650886270288596 0.89914499319121 -0.655649958620686 0.904243681017221 0.990831778717778 -0.146211704979444 0.55044760420435 0.947060194029534 -0.854203907499494 "MDM2 MUT" "GDC.0449_IC_50" 0.36354540722579 0.787306955898826 0.35439307843137 0.904277315818799 0.990831778717778 -0.0417935427961087 0.337412628078576 0.905687542642891 0.368788457848041 "PIK3R1 MUT" "Lapatinib_IC_50" 0.74600815292115 0.930911677124172 0.260248954703834 0.904311959041919 0.990831778717778 -0.0831279396736956 0.69567596489106 0.961100601384891 0.273218229917395 "FGFR2 MUT" "Pyrimethamine_IC_50" 0.143155196591092 0.61606176606809 1.97176125850341 0.904537042864599 0.990831778717778 0.14008024008165 0.475668030261039 0.929855889225741 1.17720045967488 "MYC MUT" "AMG.706_IC_50" 0.536742521385535 0.860435078055042 0.130409071729957 0.904585142594827 0.990831778717778 0.0234216472059188 0.480100426917257 0.930304161706959 0.143805801450132 "MS-HL MUT" "AP.24534_IC_50" 0.365262540225434 0.787984332414431 -0.319234771930806 0.90462380986982 0.990831778717778 0.0382746690444725 0.847518614983116 0.98378870157398 -0.0709444331530856 "MSH2 MUT" "AICAR_IC_50" 0.430626485066121 0.820918238409269 -0.554857212475638 0.904664467429367 0.990831778717778 -0.0754586753276659 0.700292850386267 0.961100601384891 -0.260982286465443 "APC MUT" "PF.562271_IC_50" 0.846853877322822 0.961922915032848 0.0539018686363636 0.904835211734276 0.990831778717778 0.0285941360748276 0.731740121177741 0.966619666247139 -0.114697647349139 "TET2 MUT" "PLX4720_IC_50" 0.547965771415253 0.863770680855317 -0.657486325670502 0.905053188738837 0.990831778717778 0.117388332849247 0.330712468520529 0.902810042912437 1.18730046244852 "FLCN MUT" "Cyclopamine_IC_50" 0.453248926087538 0.828509891052426 0.643142268041236 0.905156138481356 0.990831778717778 0.0936859306758903 0.475029103986988 0.929844139269115 1.08363866409816 "EGFR MUT" "JW.7.52.1_IC_50" 0.446990517154815 0.825993088400314 0.65776317421603 0.905159799977507 0.990831778717778 -0.0619036305408459 0.198152735851591 0.851001889249827 1.14097866466277 "PIK3R1 MUT" "NU.7441_IC_50" 0.678059772394687 0.908720747099578 0.211632807385227 0.905161797098357 0.990831778717778 0.0533197758471971 0.880317277350313 0.988301482344111 0.073673986211138 "MYCL1 MUT" "Vinblastine_IC_50" 0.661827291173541 0.902732018570453 0.278356678023033 0.905274548787506 0.990831778717778 0.054707609261299 0.570087792577422 0.949294892873838 0.371627572770649 "MLH1 MUT" "Bryostatin.1_IC_50" 0.385723136579266 0.798746759187088 0.318897356489679 0.905366048869691 0.990831778717778 0.0417247368328709 0.689370094464631 0.961100601384891 0.141382954764241 "FLCN MUT" "IPA.3_IC_50" 0.210265477647467 0.684261946425694 1.16080305244755 0.905428277560121 0.990831778717778 0.0924121006145529 0.308829774145693 0.89718581932126 1.1265609958784 "ERBB2 MUT" "Cytarabine_IC_50" 0.00607113719748871 0.135471782539943 1.33731470266543 0.905743044066376 0.990831778717778 0.0453009107720687 0.32960995475108 0.902810042912437 0.470670030585165 "PIK3CA MUT" "PF.4708671_IC_50" 0.478144677656465 0.836304203722611 -0.128456335225767 0.905766040502661 0.990831778717778 -0.0213164747374159 0.974516441487853 0.99742775226181 -0.00643530886891742 "BRCA2 MUT" "DMOG_IC_50" 0.630310189396489 0.892788643067021 0.353485590277783 0.906001157937049 0.990831778717778 0.0784611586920027 0.699285956700296 0.961100601384891 -0.270261593165526 "FLCN MUT" "KIN001.135_IC_50" 0.742584529606481 0.929570057037101 -0.148098310810811 0.906007274711585 0.990831778717778 -0.0520303668737762 0.864956706717429 0.987077901072027 0.126992297485711 "EP300 MUT" "GDC0941_IC_50" 0.921318522790136 0.986093099936007 0.10389409259259 0.906334901251647 0.990831778717778 0.100096154092388 0.816728538380893 0.977383317127464 0.240576065843088 "FAM123B MUT" "NU.7441_IC_50" 0.530959806991319 0.856734402332693 0.449892052475245 0.906360549253543 0.990831778717778 -0.0741697828044754 0.920259813692035 0.993931766508607 0.0703095628300496 "SMARCA4 MUT" "LFM.A13_IC_50" 0.889781615381468 0.975694595160244 -0.0466584645036943 0.907003331652243 0.990831778717778 -0.0368957847654456 0.550656274280507 0.947060194029534 -0.224781352942695 "NRAS MUT" "SL.0101.1_IC_50" 0.549793326066016 0.864962715463648 -0.124109275942608 0.907088839101254 0.990831778717778 0.0216086790243095 0.325552298052818 0.900918773778407 0.223236110265723 "AKT2 MUT" "AS601245_IC_50" 0.359689321196186 0.786601117838604 -0.627220266666672 0.907139412272241 0.990831778717778 0.0637504818816633 0.403570788477263 0.91712184556463 -0.572296789286792 "AKT2 MUT" "IPA.3_IC_50" 0.450881087024282 0.828077050034054 -0.591685488220555 0.907280662516392 0.990831778717778 0.0766476163705521 0.0911605313362702 0.764454987127048 -1.24559256178153 "GNAS MUT" "Docetaxel_IC_50" 0.39108878525198 0.80203322462302 0.589680628237253 0.907314510901552 0.990831778717778 0.0599734937715149 0.740196781372653 0.96672489654949 0.219966472366212 "FLT3 MUT" "AZD6482_IC_50" 0.834107382807944 0.959122768755193 -0.206620669550172 0.907379200620744 0.990831778717778 0.09793327710497 0.783213334481195 0.974053721261378 -0.266873635105486 "PIK3CA MUT" "Elesclomol_IC_50" 0.787285191223753 0.946449577332088 0.0858332747943888 0.907432086635259 0.990831778717778 0.0310404440564685 0.359182306090262 0.91161229252998 0.302986229113062 "CDKN2A MUT" "Doxorubicin_IC_50" 0.0278322089719663 0.309275185547668 -0.360133703950433 0.907553306678212 0.990831778717778 0.0124692907513101 0.935440598397102 0.994729228933513 -0.014479647230133 "EGFR MUT" "Salubrinal_IC_50" 0.565183845621598 0.871775968539349 0.318190877192983 0.907736045663329 0.990831778717778 -0.052372813784205 0.40221866066616 0.916823093416154 0.46487028989042 "HRAS MUT" "Axitinib_IC_50" 0.730481795608966 0.927803352123478 -0.25152017144678 0.907863137416815 0.990831778717778 -0.071600325960336 0.711295564096134 0.962630898212352 -0.237298605301047 "MET MUT" "Erlotinib_IC_50" 0.89351262438419 0.976022725555062 0.163359927272729 0.908032073240544 0.990831778717778 -0.126359422331866 0.687067762373196 0.961100601384891 0.480442124269762 "NF2 MUT" "Elesclomol_IC_50" 0.268016375924563 0.731489745211169 -0.536950288807646 0.908070682980392 0.990831778717778 -0.0468784182740707 0.588594154301787 0.949294892873838 0.264901362194758 "MLLT3 MUT" "PF.562271_IC_50" 0.596031975862811 0.879149639202396 -0.17681549853896 0.908338582902736 0.990831778717778 0.0311684023543503 0.90836959991061 0.989534075687441 0.0392907880333855 "CDK6 MUT" "NU.7441_IC_50" 0.708456338860257 0.917841100717424 0.190640367265469 0.908411732329183 0.990831778717778 0.0513246932114406 0.839504592880233 0.98178039101519 0.099162288033267 "CDK4 MUT" "AZD8055_IC_50" 0.150232691724187 0.624925777612415 0.686215542838015 0.908545694431209 0.990831778717778 0.0427817629048179 0.429141452854683 0.922428741067589 0.385697222253907 "CDK4 MUT" "Cytarabine_IC_50" 0.274531578852656 0.73402283606276 0.691733990366091 0.90855513251664 0.990831778717778 0.0551297329838895 0.308434376400406 0.89718581932126 0.625764227475628 "PIK3CA MUT" "AG.014699_IC_50" 0.96735383764119 0.994434372972651 -0.0090738920252561 0.908759061502652 0.990831778717778 -0.0226575088696821 0.291969558245936 0.891803870430294 -0.237003247166906 "STK11 MUT" "AP.24534_IC_50" 0.433308022359202 0.822749994507661 0.452002477150543 0.908805845387232 0.990831778717778 -0.0596342025231224 0.928033163699641 0.994186152404781 0.0521609242870079 "CDK6 MUT" "PD.173074_IC_50" 0.561731238594864 0.870491471862243 0.281069262926294 0.908882502503413 0.990831778717778 0.0474072713021117 0.789071276405023 0.975340917051672 -0.119020594947181 "RUNX1 MUT" "Bryostatin.1_IC_50" 0.88103225473723 0.973189981880763 0.0847441101398619 0.908929579423212 0.990831778717778 -0.06084775388603 0.747417423795369 0.968780465757047 -0.193549820229168 "EGFR MUT" "Thapsigargin_IC_50" 0.592973405490258 0.878261059495448 0.327284029822633 0.909028522165332 0.990831778717778 0.0536429465008291 0.463267059399484 0.929276781658587 0.458863629408815 "TSC1 MUT" "RDEA119_IC_50" 0.243442446020181 0.712594714273313 1.93180466930696 0.909120059071343 0.990831778717778 0.171665695494561 0.276582457794742 0.884207634152307 1.53944617262314 "FLT3 MUT" "BI.D1870_IC_50" 0.877578013994451 0.971802715567801 0.1435330451654 0.909245524899942 0.990831778717778 -0.092631736503824 0.523786636558759 0.940554660491705 0.565878895307156 "BCR_ABL MUT" "BMS.754807_IC_50" 0.28575680024013 0.740532869253749 1.23241854363004 0.90933398619157 0.990831778717778 0.133123451119201 0.542109070631227 0.945765861891114 0.704131832550845 "NF2 MUT" "Obatoclax.Mesylate_IC_50" 0.716893947640439 0.921306561002511 -0.185649772010964 0.909455878704259 0.990831778717778 0.0431894470137447 0.985235800627293 0.998124818853736 0.00979966852162377 "PIK3R1 MUT" "RO.3306_IC_50" 0.667782017581512 0.905919726780999 0.224773300395254 0.909615332960146 0.990831778717778 -0.0566438628022148 0.951912482246064 0.995669074626174 0.031438591935946 "CDK6 MUT" "Salubrinal_IC_50" 0.577736100999367 0.873750949722175 0.555514041095889 0.909688249971396 0.990831778717778 -0.0928531834902896 0.385467071886163 0.915331032347709 -1.05282752367426 "TSC1 MUT" "Gefitinib_IC_50" 0.349936726104683 0.784966682190403 -1.07475759772295 0.910141996834644 0.990831778717778 0.117009026430706 0.509772833133302 0.938298970167224 -0.68208377092049 "KDM6A MUT" "CGP.60474_IC_50" 0.23457162265611 0.707962074581044 -0.567628992857139 0.910149442874046 0.990831778717778 0.040471207653758 0.417544859761283 0.922428741067589 -0.410761944196806 "MLL_AFF1 MUT" "Cisplatin_IC_50" 0.429551556682143 0.820918238409269 -0.927732404174566 0.910540832387465 0.990831778717778 -0.116317081411074 0.841860443670557 0.982408776002613 -0.227138082441305 "SETD2 MUT" "Mitomycin.C_IC_50" 0.179439375572565 0.658614416960816 2.10560149739133 0.910560929173549 0.990831778717778 0.139479482375163 0.164238634791766 0.839927262232576 2.12245329860883 "MAP2K4 MUT" "Elesclomol_IC_50" 0.826807831392365 0.957600463040636 0.139163576402323 0.910741359216905 0.990831778717778 0.0592237760891668 0.790053892994401 0.975393509832241 -0.177080883197081 "EZH2 MUT" "Tipifarnib_IC_50" 0.838485649804915 0.959212868273494 0.173524857644113 0.910761410842653 0.990831778717778 0.0632102276568011 0.778884633394497 0.972337708041191 -0.253275441092944 "MLH1 MUT" "WZ.1.84_IC_50" 0.104529265736289 0.547249836715204 0.972695208333326 0.910769922309397 0.990831778717778 0.0566495642004594 0.129291534983596 0.820170087278083 0.87678476981828 "FGFR3 MUT" "CGP.60474_IC_50" 0.197471782546778 0.673916763680921 -1.69842091156463 0.910770543042742 0.990831778717778 -0.109916695769417 0.209235626685009 0.853446327418758 -1.61441446289138 "TSC1 MUT" "Tipifarnib_IC_50" 0.675634252021435 0.908552538148308 0.663475158260876 0.911021512636302 0.990831778717778 -0.117867412564423 0.410414332380243 0.921590312482665 1.28056388450549 "VHL MUT" "PF.02341066_IC_50" 0.870736908119708 0.969753842320273 0.119361155932204 0.911089148205186 0.990831778717778 0.0764800112530797 0.656647222723973 0.958313128388245 -0.374036246104617 "KIT MUT" "NSC.87877_IC_50" 0.952658647092958 0.992561499112566 -0.0298505719237427 0.911183098495938 0.990831778717778 0.0552725345948164 0.865876802976214 0.987077901072027 0.0863302015212288 "CCND3 MUT" "BIBW2992_IC_50" 0.760954131365938 0.93574319967042 0.408754905123338 0.911383904444984 0.990831778717778 -0.143237216122547 0.619784621804588 0.950496524771391 0.61265761767147 "TSC1 MUT" "JNK.9L_IC_50" 0.840489116332986 0.959424448728358 0.195808448275865 0.911387400148638 0.990831778717778 -0.0848017459532783 0.579480445181421 0.949294892873838 0.533228518356492 "KIT MUT" "CGP.60474_IC_50" 0.555110202915847 0.867339222537114 -0.778555605442179 0.911445234089539 0.990831778717778 -0.112921112478008 0.90555343644171 0.988917021334873 0.153802533133216 "MS-HL MUT" "VX.702_IC_50" 0.314352201412049 0.760194346847454 -0.202373031300352 0.91152443802803 0.990831778717778 -0.0183015097619413 0.66584715746167 0.959206771190239 -0.0884862248524527 "PTEN MUT" "Nutlin.3a_IC_50" 0.902953315676389 0.979694707150557 0.0287480078899143 0.911533812360066 0.990831778717778 -0.024513663918051 0.404328637941324 0.917353377955789 0.207413526899079 "CCND1 MUT" "XMD8.85_IC_50" 0.155033512359877 0.630721638230745 0.831557007042248 0.911626948281177 0.990831778717778 0.0569919053384416 0.983652699125057 0.998037201065879 0.0139785040540902 "MLH1 MUT" "AZD6244_IC_50" 0.838113237059924 0.959212868273494 0.14625281740042 0.911672741714685 0.990831778717778 -0.0736308224693145 0.709660909005818 0.962630898212352 0.241158891271827 "CTNNB1 MUT" "BMS.536924_IC_50" 0.289042700239005 0.744702123824371 -1.07984394501719 0.91169814645032 0.990831778717778 -0.0832300149314341 0.257649781382078 0.877052916121269 -1.2149979163644 "NOTCH1 MUT" "MK.2206_IC_50" 0.757392190984428 0.934762260113025 -0.14956233796436 0.911861149436474 0.990831778717778 -0.0446701222328247 0.0801706051896939 0.741811190933953 0.8980802660806 "FLT3 MUT" "S.Trityl.L.cysteine_IC_50" 0.136074684703524 0.60335156031289 -1.80161498179748 0.911894050927197 0.990831778717778 -0.0739989040528578 0.156942544757395 0.837288218996252 -1.75290089712047 "SMO MUT" "PAC.1_IC_50" 0.360130632263457 0.786601117838604 -1.11847983652174 0.911961608992476 0.990831778717778 -0.112741310559647 0.171562256457512 0.842832361237713 -1.6033929184521 "RB1 MUT" "JNK.Inhibitor.VIII_IC_50" 0.819971952814904 0.955629000670661 -0.0367528798908099 0.911984694644497 0.990831778717778 -0.0172359253908422 0.606017814559468 0.949657634568742 -0.0930788059730324 "KDM6A MUT" "Paclitaxel_IC_50" 0.0785770625652943 0.486980385654137 -1.17440151601423 0.912158307808102 0.990831778717778 -0.0323107775913454 0.198266399645372 0.851001889249827 -0.935161101095601 "RB1 MUT" "Pyrimethamine_IC_50" 0.839940002485471 0.959424448728358 -0.0753098986662048 0.912211613564441 0.990831778717778 0.0358424622512462 0.19503817061159 0.851001889249827 -0.570173898658686 "KDM6A MUT" "X17.AAG_IC_50" 0.354548742216619 0.785252181551816 -0.487154534817725 0.91222148590762 0.990831778717778 -0.0515626010341796 0.647303906238903 0.957449344088104 -0.218008801224814 "SOCS1 MUT" "X681640_IC_50" 0.616055381752718 0.885815598771911 -0.579396588235284 0.91250547358073 0.990831778717778 0.108726934698092 0.987192957435337 0.998124818853736 0.0173845229963053 "MLLT3 MUT" "BMS.509744_IC_50" 0.845399625120013 0.961207792944672 -0.108655822299652 0.912606350548247 0.990831778717778 -0.0450013368504068 0.849555218688074 0.984337428855677 -0.109518924847088 "KDM6A MUT" "FTI.277_IC_50" 0.931218038223486 0.986689293492114 -0.0211395100585691 0.912667498559257 0.990831778717778 -0.024599649291978 0.990448206870224 0.998681346929993 0.00294736549637644 "SMARCA4 MUT" "GNF.2_IC_50" 0.826635256110209 0.957600463040636 -0.15934302502844 0.912795657541906 0.990831778717778 -0.0761396712176752 0.490014500295409 0.933639405738697 -0.876185262327327 "PIK3CA MUT" "VX.680_IC_50" 0.449594363297058 0.827876330176482 0.563593883392226 0.912974833127147 0.990831778717778 0.0531332487097446 0.597926142217662 0.949294892873838 0.445120652905969 "SMARCA4 MUT" "NVP.TAE684_IC_50" 0.794216652859363 0.948646027682356 -0.371564262626258 0.913051862764157 0.990831778717778 0.127801014266663 0.914360163928824 0.99102179837099 -0.263726476511649 "MS-HL MUT" "CGP.60474_IC_50" 0.985606750387419 0.996887811168928 0.00576647191459651 0.913125537217305 0.990831778717778 -0.0262308996799629 0.637019591850413 0.953101495776253 0.166217394002646 "NF1 MUT" "CMK_IC_50" 0.483480444164971 0.839194763643102 0.352565389671362 0.913267868150559 0.990831778717778 -0.0503188285664019 0.799467560000488 0.976360691959787 0.151138162590157 "KRAS MUT" "Gefitinib_IC_50" 0.182046002915039 0.658636992153339 0.255110037429784 0.913639296734319 0.990831778717778 -0.0197595322122821 0.741790080845315 0.96672489654949 0.0659925898834655 "FGFR3 MUT" "Bexarotene_IC_50" 0.409792118529848 0.811995494123959 -0.766145263066193 0.913672468903117 0.990831778717778 -0.0897748558195235 0.314262383690543 0.900294798053993 -0.890717817881933 "KDM5C MUT" "Mitomycin.C_IC_50" 0.48475606903881 0.83972091053812 -0.776661080279246 0.91367419294552 0.990831778717778 0.0943102307425808 0.803239152776095 0.976532089774744 -0.268395605262707 "RB1 MUT" "Thapsigargin_IC_50" 0.511043557969081 0.849393770898084 0.24732401698986 0.913802095197409 0.990831778717778 -0.0319202522005707 0.536883557121912 0.943443271455699 -0.256314092862893 "SMARCA4 MUT" "BIBW2992_IC_50" 0.779118953981084 0.942683810925913 0.169818701348748 0.914009895037638 0.990831778717778 -0.0623853543508119 0.453420553365307 0.925809648901546 -0.478194989334475 "MSH2 MUT" "Lenalidomide_IC_50" 0.31745835111738 0.761258739353268 -0.40359161193213 0.914179343014641 0.990831778717778 -0.038200183227906 0.886755284881749 0.988301482344111 -0.0555303288175168 "JAK2 MUT" "BMS.536924_IC_50" 0.753611390219933 0.933869109446012 0.450188442176875 0.914319691999205 0.990831778717778 -0.113523203140816 0.142465980750334 0.831473272394224 2.45770410484415 "CDKN2C MUT" "Embelin_IC_50" 0.510040064142405 0.849206188535564 0.300808306878306 0.914475426117542 0.990831778717778 0.0393378930965253 0.504466500556832 0.93503055238173 0.359769970154433 "PDGFRA MUT" "Cisplatin_IC_50" 0.714221560031365 0.9199422298243 -0.272833677480918 0.914561659246592 0.990831778717778 -0.0692557931342377 0.860617227690045 0.985524480087535 -0.127232342793532 "SETD2 MUT" "Paclitaxel_IC_50" 0.479714816285372 0.836304203722611 1.30546692881356 0.914646050987142 0.990831778717778 0.0884468589885608 0.24321721426114 0.875707386589409 2.17330027821805 "FLCN MUT" "AP.24534_IC_50" 0.250004604464102 0.7169166587813 1.42928941005198 0.914821294053488 0.990831778717778 0.119539358788515 0.208165751725589 0.853446327418758 1.88958057295112 "CCND2 MUT" "Gemcitabine_IC_50" 0.82847772236453 0.958015830101332 0.508260785714282 0.914857625662585 0.990831778717778 -0.166966267551737 0.533599560448017 0.943443271455699 -1.67070595379663 "TET2 MUT" "Lapatinib_IC_50" 0.346260578672649 0.782020929432191 0.972928477508657 0.915055115594485 0.990831778717778 0.0962815504424736 0.866688461689271 0.987077901072027 0.185660600428813 "MDM2 MUT" "GNF.2_IC_50" 0.506769458835199 0.847796212975596 -0.375280594501719 0.915060996960239 0.990831778717778 -0.0575581158953213 0.77945475587022 0.972337708041191 -0.16114569852563 "SMO MUT" "AS601245_IC_50" 0.549108740485159 0.864873049004332 -0.764310264347829 0.915073609847986 0.990831778717778 0.108355006272049 0.434382640640589 0.922569292988365 -0.981498623251705 "KDR MUT" "FH535_IC_50" 0.678599035153949 0.908837606441414 -0.381322519744479 0.915144379205922 0.990831778717778 0.0840755601445764 0.674626870339949 0.960256725054738 0.373695036562458 "EP300 MUT" "AZD6482_IC_50" 0.948257239566983 0.990899019819731 -0.0738646753022427 0.915164122663276 0.990831778717778 -0.102790269297577 0.692088888132447 0.961100601384891 0.437856237933978 "PIK3CA MUT" "Doxorubicin_IC_50" 0.504522035110821 0.847595766822021 -0.185985746476879 0.915176916298003 0.990831778717778 -0.0186562840667988 0.214834431713157 0.859434499119166 -0.360927926810789 "KRAS MUT" "Vinblastine_IC_50" 0.00412296146195729 0.105218450412766 0.601530891332873 0.915267673673645 0.990831778717778 0.0171275008270742 0.675814779938219 0.960256725054738 0.0959875855988787 "STK11 MUT" "NSC.87877_IC_50" 0.887613305214434 0.975214727041194 0.0329809139784955 0.91537776681016 0.990831778717778 0.0244162386780501 0.393389220119 0.915926348152589 0.215063433685412 "CDKN2C MUT" "BIRB.0796_IC_50" 0.49929487337897 0.845109283443017 0.29261628131021 0.915440661402464 0.990831778717778 0.0442306344658813 0.513152877686847 0.939635632721979 0.2999663367743 "TET2 MUT" "Z.LLNle.CHO_IC_50" 0.812715082446395 0.953718819162788 0.249600294653012 0.915544948439163 0.990831778717778 -0.103977100292661 0.590969129618113 0.949294892873838 -0.672336342935951 "FGFR2 MUT" "Rapamycin_IC_50" 0.186683648468651 0.662394203631185 2.30810235353534 0.915838103001634 0.990831778717778 -0.16326337638528 0.599885969424962 0.949657634568742 1.13462049242839 "TET2 MUT" "OSI.906_IC_50" 0.917015108403443 0.984975746996111 0.12293676074332 0.915919587281457 0.990831778717778 0.11932832678909 0.928379610855131 0.994186152404781 0.130537413525471 "MSH6 MUT" "LFM.A13_IC_50" 0.893673610215569 0.976022725555062 0.0526289103690689 0.915978003915674 0.990831778717778 0.0390071590180452 0.995603808006409 0.999545005862799 -0.00214672751147634 "EGFR MUT" "GSK.650394_IC_50" 0.597303932735957 0.879232253518807 0.233930996232931 0.916158592549496 0.990831778717778 0.0303679616447893 0.42419360819092 0.922428741067589 0.370422403279314 "MYCL1 MUT" "ATRA_IC_50" 0.773585424907801 0.94153218611416 -0.176803368725867 0.916230148655362 0.990831778717778 -0.050808830884566 0.913845259545118 0.990970181109792 -0.0638748744325275 "CDKN2C MUT" "Pazopanib_IC_50" 0.813913302903513 0.953913887475092 0.141479599647265 0.916626113852971 0.990831778717778 0.0537496667372935 0.0591196996164554 0.70215997387469 1.234283217065 "MSH6 MUT" "Nutlin.3a_IC_50" 0.452249978416214 0.828509891052426 -0.575804830708657 0.916676863887441 0.990831778717778 -0.0734573745015518 0.709762242031249 0.962630898212352 -0.274194169879885 "APC MUT" "A.443654_IC_50" 0.588738466992066 0.876506729771444 -0.33684337671451 0.916735787276608 0.990831778717778 -0.0434584527792118 0.920314339859986 0.993931766508607 -0.0754701368954086 "NRAS MUT" "BI.D1870_IC_50" 0.323047827624616 0.764655585590143 -0.271018469773857 0.916834947289087 0.990831778717778 0.0256616117831031 0.550734515708704 0.947060194029534 -0.176868924216119 "TP53 MUT" "ABT.263_IC_50" 0.41274506883176 0.812480994891775 0.166760651680222 0.916866949983564 0.990831778717778 0.0201189496302688 0.677519934728673 0.960730407205068 -0.0791181073372 "CDK4 MUT" "Doxorubicin_IC_50" 0.993409538353528 0.998970779334534 -0.00573469617750549 0.916949181320658 0.990831778717778 -0.0452752281905678 0.921062176225319 0.993931766508607 0.0695095831770507 "EP300 MUT" "BI.D1870_IC_50" 0.551745623976026 0.865580796066258 -0.554463704198488 0.916961498567351 0.990831778717778 -0.0842442723125047 0.389399349501786 0.915926348152589 -0.755786998635494 "EZH2 MUT" "AMG.706_IC_50" 0.948068328519915 0.990899019819731 -0.0419257647058823 0.917068851138836 0.990831778717778 0.0613307463661823 0.991825895200923 0.999389382012633 -0.00606439616927078 "GNAS MUT" "RO.3306_IC_50" 0.519396438790444 0.852599738673405 0.337375869565211 0.917092063480514 0.990831778717778 0.0519145948542019 0.873052182791676 0.987739302532152 0.0834815652815882 "BCR_ABL MUT" "Camptothecin_IC_50" 0.400512838757106 0.806019304668694 -0.947853689523823 0.91728196136912 0.990831778717778 -0.0904876750703313 0.323217573203794 0.900918773778407 1.0122406093529 "FLT3 MUT" "GDC.0449_IC_50" 0.485721906007106 0.840221318124096 -0.493130490006448 0.91746730534922 0.990831778717778 0.0660557880087052 0.892067583772053 0.988301482344111 -0.0956928446248327 "KRAS MUT" "Bicalutamide_IC_50" 0.575869103294125 0.872895290383193 -0.0413705898004428 0.917471721561983 0.990831778717778 -0.00770736954956558 0.29527636786114 0.894167310052 0.0829351157642454 "PTEN MUT" "Paclitaxel_IC_50" 0.693613857704265 0.913368820021033 -0.161723446034136 0.917505182494587 0.990831778717778 0.0188161542871803 0.709592164804472 0.962630898212352 -0.164962069368554 "STK11 MUT" "GNF.2_IC_50" 0.678487986708775 0.908837606441414 -0.234380525773197 0.91752093569474 0.990831778717778 -0.0560088655756251 0.949684005340099 0.995668765770473 0.041342665589796 "SMARCB1 MUT" "JNK.9L_IC_50" 0.62219220407949 0.888816394287961 -0.479338143103447 0.917648187499524 0.990831778717778 0.0784392471244832 0.412168336672284 0.921714070263062 -0.80075297723799 "NOTCH1 MUT" "Salubrinal_IC_50" 0.0395864206671682 0.361141839503332 -1.03954690812721 0.917658978288814 0.990831778717778 0.0453546546156129 0.0240604664053436 0.569786836641336 -1.30467274563263 "IDH1 MUT" "X681640_IC_50" 0.658742244651355 0.902400992643984 -0.510317480730215 0.917706249157238 0.990831778717778 -0.101466890428764 0.5194704402585 0.939635632721979 -0.702908614429699 "MLL_AFF1 MUT" "VX.702_IC_50" 0.0382483539154838 0.354296016737578 -2.19546204198475 0.917878158972653 0.990831778717778 -0.0910304785298873 0.493892902446998 0.933639405738697 -0.683724659714189 "KIT MUT" "Z.LLNle.CHO_IC_50" 0.750590302960985 0.932697982453688 -0.409412404761905 0.917919539038837 0.990831778717778 -0.126267536528748 0.604973234673062 0.949657634568742 0.654149933804085 "PTEN MUT" "ZM.447439_IC_50" 0.257243890510068 0.72159917612758 -0.228651782654615 0.917974698428582 0.990831778717778 -0.0169006213307003 0.64914624948371 0.957493413330814 -0.0946307855658788 "BRCA1 MUT" "GNF.2_IC_50" 0.698067552274392 0.914925904921616 -0.345042765306124 0.918044219067672 0.990831778717778 -0.0872365368415693 0.904244669151872 0.988746233284632 -0.110277838768757 "SMARCA4 MUT" "GSK269962A_IC_50" 0.937200551757511 0.988395451865391 -0.105697585034014 0.918053100565977 0.990831778717778 -0.129135732788973 0.425923190161879 0.922428741067589 -1.82549473534874 "MAP2K4 MUT" "Paclitaxel_IC_50" 0.396593534742784 0.804510548663926 1.2804329047619 0.91848581412334 0.990831778717778 0.067269657323948 0.256543498698045 0.875707386589409 2.08388815337735 "ERBB2 MUT" "Salubrinal_IC_50" 0.979484646389786 0.996276778834563 0.0222666666666666 0.918518881472279 0.990831778717778 0.0744420619881673 0.474141956725304 0.929753746451187 0.63904187576454 "PIK3R1 MUT" "VX.702_IC_50" 0.650505588350786 0.898942914483331 0.241864266409269 0.918557305371051 0.990831778717778 -0.0445850232457756 0.731267605721273 0.96639568318693 0.169910193993145 "MS-HL MUT" "ZM.447439_IC_50" 0.479148998825613 0.836304203722611 -0.154218526073898 0.918860793513782 0.990831778717778 -0.0176895035485122 0.855798562169178 0.984631915507353 -0.0409243092232896 "TSC1 MUT" "PD.173074_IC_50" 0.634002937361647 0.89399270048764 -0.485870507812492 0.919084810355181 0.990831778717778 0.0887956740124145 0.863922664054692 0.987070266238225 0.160676135053542 "SMO MUT" "AZD7762_IC_50" 0.542667643319528 0.862633715268747 0.770749687619054 0.919137043624578 0.990831778717778 0.10008094348149 0.965085584702275 0.997126446878798 -0.050241139429898 "CTNNB1 MUT" "AZD8055_IC_50" 0.647262122484306 0.897186614618066 -0.197989850073311 0.91923444667161 0.990831778717778 -0.0341548631403788 0.198227674805148 0.851001889249827 -0.597055890271071 "ALK MUT" "Epothilone.B_IC_50" 0.866896525895181 0.96805080428456 0.277112125217391 0.91923739030104 0.990831778717778 0.0955671111800943 0.895048687561455 0.988301482344111 -0.299763321820709 "MLL_AFF1 MUT" "ABT.888_IC_50" 0.0390418227278936 0.35856300687324 -1.54264947428575 0.919353834164206 0.990831778717778 0.0651388885068796 0.614499704903798 0.950059945073224 -0.356998377585853 "PIK3CA MUT" "ZM.447439_IC_50" 0.288299548396905 0.743664502093737 0.254758118981788 0.919515926615224 0.990831778717778 -0.0195018296956156 0.57571632098284 0.949294892873838 -0.140047863945624 "SMAD4 MUT" "BMS.708163_IC_50" 0.725436592792945 0.924863965058017 -0.0861214624455731 0.919534650118084 0.990831778717778 -0.0257426024759341 0.696206832360405 0.961100601384891 -0.102800427856994 "APC MUT" "Lenalidomide_IC_50" 0.350463899702023 0.784966682190403 0.183397120741028 0.919580000760604 0.990831778717778 -0.01828127094018 0.391966487143233 0.915926348152589 0.198110061483607 "KDR MUT" "Gefitinib_IC_50" 0.704383543066438 0.915500829364901 0.356663423954374 0.919621955313449 0.990831778717778 0.0853082948457778 0.306890254941124 0.896682870760742 -0.874142996531913 "FLT3 MUT" "Bleomycin_IC_50" 0.300121768277048 0.751119785777076 -1.71394533158817 0.919726865196485 0.990831778717778 -0.138028754308379 0.488042928289812 0.933639405738697 -1.1128799307336 "MYCN MUT" "SL.0101.1_IC_50" 0.464081011039469 0.829490249358073 -0.19841239802694 0.919790998085527 0.990831778717778 0.0246927377498483 0.710430812734914 0.962630898212352 0.117531076206478 "TP53 MUT" "A.443654_IC_50" 0.362741469539844 0.787293170741334 -0.223617187487587 0.919798012849757 0.990831778717778 0.0171126998877413 0.6368738558889 0.953101495776253 -0.130510217042452 "BRAF MUT" "CCT018159_IC_50" 0.607371547921114 0.883983401685908 0.106442343132952 0.919828199937276 0.990831778717778 -0.0214591808715149 0.42229012381608 0.922428741067589 -0.197321836752018 "FAM123B MUT" "Nilotinib_IC_50" 0.504587188288258 0.847595766822021 0.548623386666673 0.919874790623587 0.990831778717778 0.0669944251113088 0.5706115864445 0.949294892873838 0.425868706602558 "KDM6A MUT" "MK.2206_IC_50" 0.415448856232755 0.814099702076568 -0.349096946458187 0.920021116765713 0.990869213921452 -0.0347165862167432 0.339482042633652 0.907039453844874 -0.412405373439035 "CCND1 MUT" "Bicalutamide_IC_50" 0.608904097962447 0.884360685431551 -0.0625555717171711 0.920633617221033 0.991253384454589 -0.0116864221686002 0.813462892384506 0.977383317127464 0.0289950617664474 "APC MUT" "Dasatinib_IC_50" 0.663325304550962 0.903526384925934 -0.522934593301432 0.920642274154159 0.991253384454589 -0.101980463606065 0.742161515424133 0.96672489654949 -0.407755948140279 "SMO MUT" "TW.37_IC_50" 0.999842122472917 0.999842122472917 -0.000189224215246526 0.920825343428247 0.991253384454589 -0.085827599832166 0.467756524194215 0.929276781658587 -0.66224620752106 "PTEN MUT" "AG.014699_IC_50" 0.41064847478013 0.812480994891775 -0.162924317744735 0.921077143385529 0.991253384454589 -0.0177963434821494 0.995544667738264 0.999545005862799 0.00112039113116824 "FAM123B MUT" "X17.AAG_IC_50" 0.520791927470114 0.852599738673405 0.707252605162516 0.921110937320516 0.991253384454589 -0.0961204573846292 0.793285657167413 0.975393509832241 0.257310725776986 "PIK3R1 MUT" "TW.37_IC_50" 0.322165691110114 0.762974267399712 0.508644621315198 0.921140542823041 0.991253384454589 -0.0460768531045675 0.74150781547229 0.96672489654949 0.162640028929669 "CCND1 MUT" "EHT.1864_IC_50" 0.990056469389005 0.998036562927507 0.00312899921197804 0.921197542617571 0.991253384454589 0.0249378396013713 0.487289670374507 0.933639405738697 -0.182797300823095 "CDH1 MUT" "Bexarotene_IC_50" 0.374063341039596 0.794193236181393 0.479506351917062 0.921270739251006 0.991253384454589 0.048239034735998 0.522193854528252 0.939919936320746 0.353160568023665 "MET MUT" "Rapamycin_IC_50" 0.502634955552347 0.846565396668817 1.43423791610737 0.922089214409893 0.991841913265702 0.178937202925256 0.517577193206723 0.939635632721979 1.40400461735524 "TET2 MUT" "Bosutinib_IC_50" 0.193975391010421 0.669007940801379 -1.35057668384228 0.922094047688045 0.991841913265702 0.0844658050588106 0.336481938723855 0.905430766021494 1.13792026155316 "BCR_ABL MUT" "S.Trityl.L.cysteine_IC_50" 0.382728366955087 0.798569876743396 -0.91638359931508 0.922152761832553 0.991841913265702 0.071035498078552 0.529655887513237 0.94315521189351 -0.68393278439136 "KDM5C MUT" "Thapsigargin_IC_50" 0.835756812887171 0.959122768755193 -0.299335329842937 0.922604401565319 0.992207518806199 0.107094980143005 0.612389762633785 0.949930222127033 -0.70832777030649 "HRAS MUT" "Docetaxel_IC_50" 0.366022489469878 0.788563052166059 -0.670635963683518 0.923158788413684 0.9924349989847 0.0537955924911309 0.634265911424665 0.952678811939519 -0.340042185580733 "CDKN2C MUT" "Camptothecin_IC_50" 0.84604377562188 0.961693942313825 0.155439132437622 0.923205682206821 0.9924349989847 0.0490201494142018 0.651419256878148 0.958313128388245 0.341811255108338 "GNAS MUT" "Imatinib_IC_50" 0.986006368302416 0.996887811168928 -0.012279966101695 0.923608084887663 0.9924349989847 -0.0660497473577205 0.860235531349169 0.985520092093907 0.133825903368441 "ALK MUT" "AMG.706_IC_50" 0.407003991177583 0.809352267869285 -0.615500241356822 0.923768592543062 0.9924349989847 0.0658082674379698 0.902179323143909 0.988746233284632 -0.103519130008747 "PIK3CA MUT" "Z.LLNle.CHO_IC_50" 0.831963027437848 0.958611936552287 -0.109265222886654 0.923828115192764 0.9924349989847 -0.0453956876820061 0.612314522776304 0.949930222127033 -0.278515955442467 "BRCA1 MUT" "KU.55933_IC_50" 0.528437098441 0.855147571292734 0.397109851485147 0.923838743267522 0.9924349989847 0.0536937796222218 0.775229362016526 0.972156447905785 0.176685205385752 "FAM123B MUT" "RO.3306_IC_50" 0.516701862485889 0.852353345422823 0.551770332681027 0.923925364195135 0.9924349989847 -0.0774544294220045 0.915622227210498 0.9920264730824 -0.0907238871768461 "MLH1 MUT" "FTI.277_IC_50" 0.641499854489948 0.896094514063559 0.149644519298246 0.923941381601064 0.9924349989847 0.0282826576666728 0.95870375558599 0.99641548698706 -0.0159025479204025 "FGFR3 MUT" "Vinblastine_IC_50" 0.990542371927167 0.998036562927507 0.0150025958254277 0.923975913357321 0.9924349989847 0.087309018761113 0.983066041529785 0.998011368051263 0.0251372655200387 "MYC MUT" "Nilotinib_IC_50" 0.6916223341103 0.912974964595134 0.105667015843662 0.924096374816661 0.9924349989847 -0.020666185937501 0.591130112599625 0.949294892873838 0.134629199580713 "NF1 MUT" "Doxorubicin_IC_50" 0.0397382213921761 0.361141839503332 0.851791681133262 0.924262335835135 0.9924349989847 -0.0247605811783579 0.300891755261285 0.894167310052 0.441971692420332 "PIK3CA MUT" "TW.37_IC_50" 0.838452834193681 0.959212868273494 0.0424137924338093 0.924292307129435 0.9924349989847 -0.0181438893198875 0.643400470401358 0.955972780483685 -0.101117543155007 "SMARCA4 MUT" "AG.014699_IC_50" 0.899557774309341 0.979160754215132 0.058048244292237 0.924715849365483 0.9924349989847 0.0379575093007418 0.92493991825185 0.994026707431102 0.0458773372008396 "GNAS MUT" "Paclitaxel_IC_50" 0.190339950825341 0.664991779417723 -1.97636403401362 0.924897368614826 0.9924349989847 -0.062186305950217 0.471552126531774 0.929276781658587 -1.09276079079895 "FLCN MUT" "JNK.9L_IC_50" 0.200505160408218 0.674012093366938 0.789154746967065 0.92497383912625 0.9924349989847 0.0453884709366621 0.41504836023342 0.92211126027385 0.640774726197766 "EP300 MUT" "AZD.2281_IC_50" 0.69235468500747 0.913066921534475 0.343048925049316 0.925359309430336 0.9924349989847 0.061601205791807 0.936612713552866 0.99481859098592 0.0602593186209335 "PIK3R1 MUT" "WH.4.023_IC_50" 0.382469448598603 0.798569876743396 1.39797184192441 0.925459183670779 0.9924349989847 0.130023131628021 0.322155976233679 0.900918773778407 1.46609151807091 "KRAS MUT" "JW.7.52.1_IC_50" 0.275252042502875 0.734088104945354 -0.636536455093618 0.925630356085164 0.9924349989847 -0.035169789364408 0.562123426261144 0.949294892873838 -0.376674468883494 "MET MUT" "JW.7.52.1_IC_50" 0.551692109093635 0.865580796066258 1.13575142372882 0.925689486363195 0.9924349989847 0.107411613658755 0.322257582744123 0.900918773778407 1.91767289064789 "EGFR MUT" "WH.4.023_IC_50" 0.495344560687949 0.843282996121548 0.778653307692304 0.926210343195017 0.9924349989847 0.0911272292197556 0.188184911039064 0.851001889249827 1.41650395411231 "CDK4 MUT" "Etoposide_IC_50" 0.721159492344625 0.922822998769296 0.311193277003484 0.926230068959871 0.9924349989847 0.0527436320379579 0.578261330696687 0.949294892873838 0.487307893053267 "CDK6 MUT" "Obatoclax.Mesylate_IC_50" 0.66718155717438 0.905722930184296 0.352593902899824 0.926312264915532 0.9924349989847 -0.0556906216274878 0.765616462408913 0.969901216545994 0.250773387859462 "RB1 MUT" "Vinblastine_IC_50" 0.962250888002194 0.994038633982492 -0.0117662558020353 0.926372802422977 0.9924349989847 -0.0170148108118415 0.797982126188431 0.976360691959787 -0.0660626255661037 "ERBB2 MUT" "VX.680_IC_50" 0.957152530124217 0.99327782426188 0.081972249146758 0.926421991788995 0.9924349989847 -0.0936967741768173 0.689810176352551 0.961100601384891 -0.645127066132773 "STK11 MUT" "Gemcitabine_IC_50" 0.209373257438492 0.683860903264959 1.06004174811634 0.926433057999672 0.9924349989847 -0.0523301197172743 0.474604826976809 0.929844139269115 0.602015820145803 "FBXW7 MUT" "BIBW2992_IC_50" 0.430838735670965 0.820918238409269 -0.318440503952567 0.926514164765015 0.9924349989847 -0.0359004270660925 0.583093392987093 0.949294892873838 -0.217139650081758 "CCND1 MUT" "CCT018159_IC_50" 0.318012602522309 0.761258739353268 -0.290725542168673 0.926523247312778 0.9924349989847 0.0254273287514659 0.549051468623241 0.947060194029534 -0.192300787909908 "NOTCH1 MUT" "Paclitaxel_IC_50" 0.0471244492791556 0.384922051833884 -1.51858263508773 0.926601817408471 0.9924349989847 0.0329645118453509 0.00538623217538598 0.358956332448686 -2.44272859170797 "FGFR2 MUT" "Bicalutamide_IC_50" 0.499221986592234 0.845109283443017 0.210273787085517 0.926659901620793 0.9924349989847 -0.0277062257585703 0.785752120494311 0.974807190013589 0.0913996703881765 "BRCA2 MUT" "Salubrinal_IC_50" 0.415779372198571 0.814099702076568 0.992543856655299 0.926673926303521 0.9924349989847 -0.0929250619404462 0.195762854243307 0.851001889249827 1.58944973165702 "FAM123B MUT" "JNJ.26854165_IC_50" 0.300311597128388 0.751119785777076 0.59226468468469 0.926773427784918 0.9924349989847 0.0490879770055726 0.929966536015852 0.99422596912377 0.0483015368457537 "SETD2 MUT" "WZ.1.84_IC_50" 0.482049604523297 0.838752471082649 -0.835388367346941 0.927098734212295 0.9924349989847 0.0915518510091616 0.790846721584032 0.975393509832241 0.302654799820501 "MET MUT" "CMK_IC_50" 0.611074595195827 0.884877462894854 0.616126884353743 0.927473323039937 0.9924349989847 0.100147553053433 0.52451671587097 0.940554660491705 0.78990964213377 "FGFR2 MUT" "Dasatinib_IC_50" 0.306468089042675 0.755024525457845 2.31830940841865 0.927603215248894 0.9924349989847 0.173648412898343 0.943571231765976 0.995314665488626 -0.170518600112467 "MSH6 MUT" "CHIR.99021_IC_50" 0.951890967742042 0.992474158421367 -0.0308174999999997 0.927626158488668 0.9924349989847 -0.0438754989039254 0.728800468685977 0.965407830614903 -0.169845648992603 "KIT MUT" "Midostaurin_IC_50" 0.20785395453686 0.681213655034139 -1.05629389428075 0.92762879704377 0.9924349989847 -0.0588769498958521 0.709607179113717 0.962630898212352 -0.28460698592971 "STK11 MUT" "BI.D1870_IC_50" 0.535490556875292 0.859514121743984 0.212585790804003 0.927704358908955 0.9924349989847 0.0268871974460235 0.972535246791935 0.99742775226181 0.0119654301743409 "NF2 MUT" "Etoposide_IC_50" 0.587058366958182 0.876506729771444 -0.295619624140565 0.927717920560924 0.9924349989847 0.0322748109010393 0.809227189313386 0.977383317127464 0.134142091041073 "VHL MUT" "KIN001.135_IC_50" 0.608493721504742 0.884312345063592 -0.200342542372881 0.927775099219758 0.9924349989847 -0.0350496581207859 0.973704086694356 0.99742775226181 0.0126804396928995 "FGFR3 MUT" "AKT.inhibitor.VIII_IC_50" 0.464713592507413 0.829572143730318 -0.677541158894635 0.927856141115295 0.9924349989847 0.0720092119253458 0.635300424342406 0.953057950774478 -0.428153715428788 "CDH1 MUT" "PLX4720_IC_50" 0.791226734877229 0.94790644179192 0.178278192456482 0.927891236229778 0.9924349989847 -0.0548358664428394 0.356496743607444 0.91161229252998 -0.604973550091419 "EGFR MUT" "CI.1040_IC_50" 0.924773081320867 0.98643792569589 0.0360030017287576 0.927933746292256 0.9924349989847 -0.0310239849873922 0.794835986258616 0.975627957210581 -0.091592130034874 "MET MUT" "CGP.082996_IC_50" 0.664903417723607 0.903873756743204 0.502627857142859 0.927937987823804 0.9924349989847 0.0876750208235626 0.584098539967882 0.949294892873838 0.628449417340331 "BCR_ABL MUT" "Axitinib_IC_50" 3.73534021770334e-07 0.000100525928707344 -4.48096576285721 0.927994494871657 0.9924349989847 -0.0847697090731186 4.48297316064365e-05 0.0180969475634892 -3.2666008529667 "GNAS MUT" "Bicalutamide_IC_50" 0.567118520181853 0.872389778906173 -0.113236419753086 0.92800719549217 0.9924349989847 -0.0170097431396463 0.745397876569035 0.968371047127272 -0.0606769267036872 "CTNNB1 MUT" "NVP.TAE684_IC_50" 0.404857530315775 0.807904911469051 -0.842860496598635 0.928115059583056 0.9924349989847 -0.0745547015902703 0.698460270983861 0.961100601384891 -0.436332567519808 "APC MUT" "AZD8055_IC_50" 7.11066217031053e-05 0.00725859663615262 1.07013184547685 0.928172659348449 0.9924349989847 0.02015042809983 0.0042559037944931 0.343606196353575 0.930113308751263 "SMARCA4 MUT" "X681640_IC_50" 0.599963006648252 0.880698848449586 0.27322408659794 0.928531354675403 0.9924349989847 -0.0397424120978631 0.950716996283316 0.995668765770473 -0.034547408981277 "KRAS MUT" "CCT018159_IC_50" 0.22573730131707 0.698134056525989 0.213737689474429 0.928566023326396 0.9924349989847 -0.0156445447544911 0.624547128670448 0.950496524771391 0.101615187713343 "TSC1 MUT" "AZD6244_IC_50" 0.777358998418233 0.941790749776385 0.448855327835042 0.928771560548442 0.9924349989847 -0.129514483222716 0.563837248675595 0.949294892873838 0.817400870095526 "KDR MUT" "Tipifarnib_IC_50" 0.472892183562383 0.834112310271604 -0.929959728222987 0.928966056145732 0.9924349989847 -0.0768070038792008 0.548775031886115 0.947060194029534 -0.772481555457644 "ERBB2 MUT" "ATRA_IC_50" 0.473698037987679 0.834460661638643 0.304653944874612 0.92899407496008 0.9924349989847 -0.0309024175341089 0.485048611853188 0.933639405738697 -0.277653386518698 "NF2 MUT" "RO.3306_IC_50" 0.76203183463813 0.935915464447689 -0.0991684110885736 0.929171396177843 0.9924349989847 0.0280081339173136 0.437957731978624 0.922569292988365 0.271086790557169 "CCND3 MUT" "BMS.708163_IC_50" 0.892233263906747 0.975972789421281 0.116537774553571 0.929194038197456 0.9924349989847 0.0770100145875877 0.971234186002453 0.99742775226181 -0.0311922758397432 "EGFR MUT" "BIRB.0796_IC_50" 0.526209412063958 0.854969048950887 0.16782100810081 0.929234837956045 0.9924349989847 0.0226176564910563 0.762456082096402 0.969901216545994 0.0830191100306106 "BRCA2 MUT" "Lapatinib_IC_50" 0.638257207666894 0.895624997957207 0.5941018275862 0.929315851492034 0.9924349989847 -0.0974767600518433 0.187146116811101 0.851001889249827 1.48197561402591 "GNAS MUT" "VX.702_IC_50" 0.400462051358902 0.806019304668694 0.448748291505792 0.929390626881067 0.9924349989847 -0.0386263650196728 0.642225564332413 0.955537818200061 0.230354691829442 "APC MUT" "AZ628_IC_50" 0.0677502584289743 0.461747350209541 -1.51023182105262 0.929482088783418 0.9924349989847 0.0567224211556879 0.688259384976679 0.961100601384891 0.34872006617644 "EP300 MUT" "CEP.701_IC_50" 0.696328141947959 0.914265261478389 -0.417238375158423 0.929656399317513 0.9924349989847 0.0694498666696173 0.519922959897396 0.939635632721979 -0.620211905043543 "CTNNB1 MUT" "Imatinib_IC_50" 0.831128196454646 0.958603832819962 -0.122320273037543 0.929786030612189 0.9924349989847 0.0496045358224948 0.697919707455857 0.961100601384891 -0.261429024040662 "SETD2 MUT" "TW.37_IC_50" 0.82476816591825 0.957177484110155 0.211735869955154 0.929804960033695 0.9924349989847 0.0771538737693789 0.941280101889853 0.995296816798845 0.0674961795925866 "NF2 MUT" "SB590885_IC_50" 0.479564423051124 0.836304203722611 0.293645136554625 0.930040692106447 0.9924349989847 -0.0307855779554032 0.455337906907286 0.925809648901546 -0.290664496534485 "SMARCA4 MUT" "TW.37_IC_50" 0.932130097517436 0.98681842896288 -0.0367537762557074 0.930061411153732 0.9924349989847 -0.0340051533300361 0.380579740962851 0.915134825237766 0.414242928216932 "APC MUT" "MG.132_IC_50" 0.210631479265065 0.684455970491418 -0.908163696547352 0.930068786381909 0.9924349989847 -0.0583113917736452 0.393978932485755 0.915926348152589 -0.689273457843065 "MS-HL MUT" "Pyrimethamine_IC_50" 0.492415846888945 0.842990705166559 -0.27714215606584 0.930079551463761 0.9924349989847 0.0304287057525374 0.607324420416124 0.949657634568742 0.233036057028654 "RB1 MUT" "AKT.inhibitor.VIII_IC_50" 0.858064897575724 0.965651207814682 0.0367219058394783 0.930880686324893 0.992899443708211 0.0156453165485591 0.932509160375626 0.994235539701634 0.0193811408155424 "SMAD4 MUT" "GW843682X_IC_50" 0.0416022738404083 0.368149973799425 -1.8939097413793 0.930918482626848 0.992899443708211 0.0434098454426259 0.117486160058643 0.805088416266056 -1.59666912726122 "EP300 MUT" "Cyclopamine_IC_50" 0.926539047546587 0.98643792569589 -0.0967116438356186 0.931037447684903 0.992899443708211 0.0834381382194182 0.941390976366434 0.995296816798845 0.0772970716102371 "STK11 MUT" "Imatinib_IC_50" 0.695524753174875 0.913718445479852 0.245469149659866 0.931321817814408 0.992899443708211 0.053447079601682 0.322972525127683 0.900918773778407 0.745542210181972 "MAP2K4 MUT" "Doxorubicin_IC_50" 0.867691130091862 0.968516630896742 0.0911314690398247 0.931429970958645 0.992899443708211 -0.0293585230189486 0.624550292964311 0.950496524771391 0.280168339567068 "EWS_FLI1 MUT" "AKT.inhibitor.VIII_IC_50" 0.468965895570905 0.831812685952708 -0.303288047619044 0.931566408635691 0.992899443708211 -0.0328492266052399 0.141466804874315 0.831473272394224 -0.685658520618881 "BRCA1 MUT" "Nutlin.3a_IC_50" 0.969203784922927 0.994856543446662 -0.0361597725490199 0.931661946690869 0.992899443708211 -0.0737249462825263 0.906847140120012 0.989034686406218 -0.105660525254402 "KIT MUT" "Gefitinib_IC_50" 0.624320592954342 0.890411303360769 0.399058211428574 0.931877573517083 0.992899443708211 0.0627750808911935 0.398248471412378 0.916480913435499 -0.624956629841797 "TET2 MUT" "Metformin_IC_50" 0.207055754333763 0.680161611517635 -1.05125161904763 0.931910503179789 0.992899443708211 -0.0673264347139675 0.71705254657357 0.963986227227103 -0.364446139065724 "CDK6 MUT" "WZ.1.84_IC_50" 0.799156037351992 0.949963513555487 0.247380045506257 0.932228219772156 0.992899443708211 0.0692859959324745 0.89676548408808 0.988301482344111 0.146676627292614 "CDKN2A MUT" "NSC.87877_IC_50" 0.582120585812801 0.876388018749532 -0.0516040196823326 0.932232741627619 0.992899443708211 0.00823798976477842 0.516823224018378 0.939635632721979 0.0707008192998537 "BRAF MUT" "KIN001.135_IC_50" 0.967896714331224 0.994434372972651 -0.00741515037593978 0.932274932503701 0.992899443708211 0.0164986098829507 0.673999436497325 0.960256725054738 -0.0933539966668184 "FLT3 MUT" "Imatinib_IC_50" 0.860230689131105 0.966384100200122 -0.142108186936938 0.932309587080508 0.992899443708211 0.068069230035963 0.804669724645306 0.976878758490379 0.212095401439389 "NOTCH1 MUT" "WH.4.023_IC_50" 0.957846484025101 0.993340772343095 0.0576762826156297 0.932592763280294 0.992899443708211 -0.0838540532298955 0.624448199599484 0.950496524771391 -0.575264212448758 "FBXW7 MUT" "SB.216763_IC_50" 0.791773275026983 0.94805695773421 -0.0837185303337644 0.932594403868593 0.992899443708211 0.0259841400189966 0.718849596073105 0.964721180904622 0.116555316738771 "NF1 MUT" "WO2009093972_IC_50" 0.414744811332626 0.813999705954707 0.263903542071194 0.932644194843314 0.992899443708211 0.0246519601488968 0.548192749372079 0.947060194029534 0.204817345737494 "SETD2 MUT" "JNJ.26854165_IC_50" 0.833649564285749 0.959020956013178 -0.169555336322868 0.932866263967763 0.992899443708211 -0.0642173121129688 0.989806940333884 0.998596878102629 0.00976114957615842 "CDH1 MUT" "Vinorelbine_IC_50" 0.321118426863383 0.762015213745527 0.674613295520655 0.932923336342613 0.992899443708211 0.0426056898976375 0.346427920235045 0.909317472748763 0.673695728325585 "VHL MUT" "X681640_IC_50" 0.749238764815342 0.932323030730707 0.198439190281037 0.932955467595747 0.992899443708211 -0.0447312573153561 0.974105093096023 0.99742775226181 0.0192328670340389 "ERBB2 MUT" "Gefitinib_IC_50" 0.648323551641705 0.898106607725781 0.182550757927388 0.933088421635091 0.992899443708211 -0.0309656730090722 0.325297326466402 0.900918773778407 0.37825645179643 "SMARCB1 MUT" "Gemcitabine_IC_50" 0.85011261855536 0.963526482778845 -0.542491203478269 0.933235801856693 0.992899443708211 0.160644979703648 0.856466788345265 0.984631915507353 -0.492394742639098 "EP300 MUT" "VX.680_IC_50" 0.499614156571092 0.845156823715784 -1.25885935714286 0.933252004552003 0.992899443708211 0.101672525840206 0.467408087716069 0.929276781658587 -1.39958310040582 "FBXW7 MUT" "QS11_IC_50" 0.283872651392113 0.739564104351618 -0.45665153431613 0.933307436452076 0.992899443708211 0.0263044060948245 0.683277447160545 0.961100601384891 -0.176592602595526 "APC MUT" "CHIR.99021_IC_50" 0.681583725750671 0.909861476478352 0.107044861363637 0.933392037272507 0.992899443708211 0.0216603727196368 0.246566773530923 0.875707386589409 -0.35603403020498 "MS-HL MUT" "KIN001.135_IC_50" 0.393748870116773 0.803073858340542 0.116331854755519 0.933501606724385 0.992899443708211 0.0113488076271036 0.578595988886042 0.949294892873838 -0.0793103643147196 "MYC MUT" "EHT.1864_IC_50" 0.72368178644609 0.923974852378165 -0.0820151166267942 0.933630750350856 0.992899443708211 -0.01925588840466 0.963700241771443 0.997051031866061 0.0108425656717351 "PIK3R1 MUT" "Sorafenib_IC_50" 0.431501992355015 0.820944557434638 0.65609714726027 0.933643914477316 0.992899443708211 0.0658585295088303 0.483887876317703 0.932745808137526 0.596194435274231 "NF2 MUT" "ATRA_IC_50" 0.230112823109678 0.703003777790522 0.460731051862331 0.933645226259123 0.992899443708211 0.0253689778120095 0.709873706041579 0.962630898212352 0.133934820967886 "KDM6A MUT" "Cisplatin_IC_50" 0.359153212911657 0.786601117838604 -0.385864416666664 0.933860895701339 0.992899978159857 -0.0305772225534977 0.313543467205683 0.900294798053993 -0.420237256528608 "KDM6A MUT" "Elesclomol_IC_50" 0.932172764463646 0.98681842896288 -0.0470648910818711 0.934024115135189 0.992899978159857 0.0383802499777812 0.325737378031948 0.900918773778407 -0.530869816641294 "EZH2 MUT" "AUY922_IC_50" 0.829587917880377 0.958015830101332 0.154980311027571 0.934077897503792 0.992899978159857 0.0398647134691615 0.810768478855706 0.977383317127464 -0.177371771207486 "FBXW7 MUT" "AZD.0530_IC_50" 0.873284855022885 0.970547215299492 -0.10372518685121 0.934092930697625 0.992899978159857 -0.0473738014472865 0.652680782612614 0.958313128388245 -0.284843560244513 "CCND1 MUT" "AS601245_IC_50" 0.612702080382899 0.88496040166963 0.179728807811447 0.934512422891364 0.993086813691121 0.0235718318729784 0.658949354991292 0.958313128388245 0.16612799522756 "EGFR MUT" "AZD.2281_IC_50" 0.586194160815647 0.876506729771444 0.17763615033532 0.934533569057904 0.993086813691121 0.0203093764145372 0.464574579584047 0.929276781658587 -0.220077197767804 "JAK2 MUT" "Mitomycin.C_IC_50" 0.547457657606644 0.863582852078971 0.506863605764418 0.934672624752162 0.993086813691121 -0.0539187682151429 0.413751029960177 0.921714070263062 0.728007379739744 "KRAS MUT" "MS.275_IC_50" 0.498760849390125 0.845109283443017 -0.328742921411923 0.934715986447931 0.993086813691121 0.0356675771103807 0.697537154004224 0.961100601384891 -0.216249437270166 "EZH2 MUT" "PD.173074_IC_50" 0.796406764795339 0.94925279007178 -0.186556764705882 0.934913535819681 0.993116678694178 0.0501846763188903 0.782099443528967 0.973465634570267 -0.183517973221892 "CTNNB1 MUT" "JNJ.26854165_IC_50" 0.618194781911688 0.88687184464302 -0.166123119266058 0.934967745812636 0.993116678694178 0.0255136841550691 0.6948797360872 0.961100601384891 -0.137095259263114 "RUNX1 MUT" "BIBW2992_IC_50" 0.721397418340245 0.922894046712722 0.391556733206587 0.935405085575441 0.993167491650837 0.0850044191372368 0.57297801550296 0.949294892873838 0.567117034591862 "CCND2 MUT" "OSI.906_IC_50" 0.854728213443758 0.964651323369427 0.216020732868755 0.935520170966356 0.993167491650837 0.0896359161307665 0.764724105613272 0.969901216545994 -0.433309744281636 "SMARCA4 MUT" "GDC.0449_IC_50" 0.447863612613283 0.826231147407263 0.296061313725488 0.935530790924672 0.993167491650837 0.0279510433850443 0.51424376126469 0.939635632721979 0.28765742613604 "FBXW7 MUT" "BMS.536924_IC_50" 0.596592250778884 0.879232253518807 -0.420788202090595 0.935548001186867 0.993167491650837 -0.0486674988232114 0.685753974849378 0.961100601384891 -0.315613144605364 "KDM6A MUT" "WO2009093972_IC_50" 0.811915893031827 0.953452072590185 -0.107376919811321 0.93557473653315 0.993167491650837 0.0327333078744044 0.801683607631361 0.976365695720597 -0.112197252520299 "FLT3 MUT" "AMG.706_IC_50" 0.616365278701914 0.885815598771911 -0.371978910632752 0.936167123958343 0.993568680587684 0.0554056604221745 0.911679815209318 0.990339041794625 -0.07624853510032 "SMARCA4 MUT" "XMD8.85_IC_50" 0.47280051571883 0.834112310271604 0.758219690721643 0.936176412471314 0.993568680587684 0.0730700610752458 0.989002424683795 0.998559633198815 -0.0245909870924847 "PIK3R1 MUT" "BI.2536_IC_50" 0.150456423958809 0.625010754600796 1.46837323972602 0.936404151975718 0.993691632655795 0.0483083062886106 0.146895604624764 0.831473272394224 1.52100078089179 "PDGFRA MUT" "Tipifarnib_IC_50" 0.544589909874067 0.862633715268747 -0.609151188811189 0.936651978133303 0.993818020711577 -0.0531295016212114 0.646411871557915 0.957449344088104 -0.461381173555415 "EP300 MUT" "PF.562271_IC_50" 0.70069766755912 0.915410639012359 -0.341460036269423 0.936747061296769 0.993818020711577 0.0577024844580823 0.831296055329233 0.981482581683432 -0.184831084008935 "CDK6 MUT" "Shikonin_IC_50" 0.850404203209394 0.963526482778845 0.129608500290868 0.937390901132178 0.993965200107245 -0.0453872396528467 0.777923779667223 0.972337708041191 0.200098072360071 "AKT2 MUT" "X17.AAG_IC_50" 0.745666061113951 0.930717267274786 0.29230154190659 0.937537312852404 0.993965200107245 -0.0622098793894377 0.327233744213936 0.902810042912437 0.780540849958345 "MLL_AFF1 MUT" "Vinblastine_IC_50" 0.267423427436624 0.731277750163748 -1.40280774573054 0.937709640471727 0.993965200107245 -0.0727981267914358 0.985295406756595 0.998124818853736 0.0221483867938517 "MSH2 MUT" "X681640_IC_50" 0.537312941004219 0.86087328699965 -0.382914834894616 0.937784537967375 0.993965200107245 -0.0414781445028041 0.819232479016056 0.977383317127464 -0.13424996584543 "EZH2 MUT" "BI.D1870_IC_50" 0.929783329146481 0.986689293492114 -0.0637219367816094 0.937824462428009 0.993965200107245 0.04845266950224 0.897268557641574 0.988301482344111 -0.0883103273537504 "HRAS MUT" "Bleomycin_IC_50" 0.829382784820637 0.958015830101332 0.319239814685308 0.937927911462452 0.993965200107245 -0.0943353472985027 0.504477922369666 0.93503055238173 0.953272087578943 "CDKN2C MUT" "BMS.754807_IC_50" 0.647876553048136 0.897627405245007 0.335379178306877 0.937997978304353 0.993965200107245 -0.0478413974239684 0.535606496236595 0.943443271455699 0.532383658113378 "PIK3R1 MUT" "KU.55933_IC_50" 0.717355575873479 0.921306561002511 0.161908882235527 0.938052669414789 0.993965200107245 0.0309090812902574 0.998476502946455 0.999689936809094 -0.000838737947816409 "MLH1 MUT" "BAY.61.3606_IC_50" 0.171004523733048 0.649721929411943 -0.762816038643075 0.938161180046026 0.993965200107245 0.0304704031709313 0.633334204366404 0.952523560833852 -0.251457060796866 "MLH1 MUT" "LFM.A13_IC_50" 0.993642277111067 0.998970779334534 -0.00257091445427708 0.938375039855976 0.993965200107245 0.0237908739495174 0.710407288012811 0.962630898212352 -0.120068384970593 "CDH1 MUT" "Camptothecin_IC_50" 0.212293002025738 0.686649630080219 0.997777712092115 0.938454396850077 0.993965200107245 -0.0395861958380802 0.80707667067845 0.977383317127464 -0.185489184528097 "FLT3 MUT" "Roscovitine_IC_50" 0.646263289220689 0.897186614618066 -0.445399077277973 0.938516012975372 0.993965200107245 0.0668851345440938 0.858373254930334 0.985165789226712 -0.174282093563012 "CCND1 MUT" "Methotrexate_IC_50" 0.206106411120545 0.679195190041394 0.574294241260499 0.938596306823308 0.993965200107245 0.0268388143226659 0.729426489254429 0.965574102111877 -0.134602376319427 "TSC1 MUT" "Nutlin.3a_IC_50" 0.878542452488407 0.971802715567801 -0.202019441406245 0.938737500437999 0.993965200107245 -0.0931977655294332 0.783738289809779 0.974078058737889 0.35070139256252 "MLH1 MUT" "BIBW2992_IC_50" 0.510465085500525 0.849393770898084 -0.380236185503682 0.93878938484216 0.993965200107245 -0.0430848515886261 0.471993418882838 0.929276781658587 -0.387147360358637 "SMO MUT" "CEP.701_IC_50" 0.490029217914062 0.84263880174142 0.902789341555977 0.939015719981735 0.993965200107245 0.0730209208320583 0.976056175496183 0.99742775226181 0.0354615736873528 "KDM6A MUT" "Midostaurin_IC_50" 0.925524776726875 0.98643792569589 -0.0388214548001024 0.939196948606879 0.993965200107245 0.0244740796030753 0.674429558765299 0.960256725054738 -0.167957574688962 "MLLT3 MUT" "VX.702_IC_50" 0.670088560012219 0.906882709825482 0.153108510498688 0.939323361093491 0.993965200107245 -0.0223535970486693 0.99963865609373 0.999751228014461 -0.000159309645714237 "CDH1 MUT" "Erlotinib_IC_50" 0.962113812949035 0.994012653885573 -0.0368649999999997 0.939389175276688 0.993965200107245 0.0539158079750034 0.635208146904219 0.953057950774478 0.369241042578025 "CDKN2C MUT" "ATRA_IC_50" 0.675322377753487 0.908552538148308 0.257402396235523 0.939408672449093 0.993965200107245 -0.0368970688644004 0.698205639579312 0.961100601384891 0.223751897132851 "MET MUT" "Camptothecin_IC_50" 0.143740782282412 0.617247025604118 0.958349612508065 0.939648011491715 0.993965200107245 -0.0315090263430011 0.807850397522157 0.977383317127464 0.140686336528747 "EP300 MUT" "AG.014699_IC_50" 0.601016774258963 0.880741900288913 -0.435557488389518 0.939667404344102 0.993965200107245 -0.0557585529127631 0.60648777257579 0.949657634568742 -0.394556509040741 "PIK3R1 MUT" "CHIR.99021_IC_50" 0.92595101533505 0.98643792569589 0.0507070583850944 0.939697167908226 0.993965200107245 -0.039075591252062 0.878705302128813 0.987955687349291 -0.0800531364608812 "SMO MUT" "Vinorelbine_IC_50" 0.481747824642068 0.838573584995337 -1.00877433620692 0.939775452997607 0.993965200107245 -0.0791660921911843 0.506870414164051 0.936562389753569 -0.931381226652494 "AKT2 MUT" "Pyrimethamine_IC_50" 0.749850193818522 0.932697982453688 -0.525896915254238 0.940193320894184 0.993965200107245 -0.103735026428974 0.665756930330841 0.959206771190239 -0.718167185422088 "SMO MUT" "Vinblastine_IC_50" 0.542622527596333 0.862633715268747 0.770458762808347 0.94021545930185 0.993965200107245 -0.0683094170154924 0.699183898376849 0.961100601384891 0.457056224767699 "FLCN MUT" "Salubrinal_IC_50" 0.484628493152166 0.83972091053812 0.69728915525114 0.940225786605182 0.993965200107245 0.0615212904005183 0.218137214116445 0.860928912580141 2.15262912194813 "SMARCB1 MUT" "AKT.inhibitor.VIII_IC_50" 0.499395734659268 0.845109283443017 -0.765997639655172 0.94022765678316 0.993965200107245 -0.0727414156167787 0.384527250279862 0.915331032347709 -0.974987877011146 "KDR MUT" "BIRB.0796_IC_50" 0.864782253836898 0.967489995749939 -0.119891539440204 0.940233061467214 0.993965200107245 -0.0505394963343241 0.939441384473972 0.994831655017307 -0.053448284493362 "RB1 MUT" "TW.37_IC_50" 0.944108749668878 0.990147156460271 0.0160418097560978 0.940355301010341 0.993965200107245 -0.0158256402443699 0.624543849642489 0.950496524771391 0.116455000447208 "FGFR2 MUT" "BMS.509744_IC_50" 0.0653209125867663 0.457742485196035 1.84733221088436 0.940355321619308 0.993965200107245 0.0570159250596236 0.436725109345386 0.922569292988365 0.936377328395626 "MAP2K4 MUT" "OSI.906_IC_50" 0.691269065867484 0.912932803156675 -0.227065726677575 0.940542405712214 0.994044639429986 -0.0403107521434299 0.580372748267136 0.949294892873838 -0.349047976874456 "SMAD4 MUT" "Parthenolide_IC_50" 0.679731697527964 0.909220155851267 -0.235855652920963 0.941102186602773 0.994517910425896 -0.0407222360065784 0.516760781287123 0.939635632721979 -0.405661936416529 "CCND1 MUT" "Bexarotene_IC_50" 0.642949944101846 0.896094514063559 0.146761226464646 0.941558325254727 0.994588914724909 0.0208495410335232 0.696690691704062 0.961100601384891 0.126411224656145 "FLCN MUT" "Imatinib_IC_50" 0.682896753231308 0.910084943794605 0.329658592342344 0.941567527960221 0.994588914724909 0.0582417910362437 0.686446142075848 0.961100601384891 0.607385564255055 "SMAD4 MUT" "KIN001.135_IC_50" 0.701533024707862 0.915500829364901 -0.106730541237114 0.941846182757341 0.994588914724909 0.0207776339867403 0.994274581696146 0.999545005862799 0.00199421418689473 "KIT MUT" "SB590885_IC_50" 0.566927440115494 0.872389778906173 0.523098140243906 0.941848332850503 0.994588914724909 -0.0559322228452647 0.761935189851644 0.969901216545994 0.244366144653775 "MDM2 MUT" "Pyrimethamine_IC_50" 0.910764027721949 0.98209025378808 0.117522979452055 0.94187303057149 0.994588914724909 0.0645737521280918 0.946094116454548 0.995668765770473 -0.0712235042296788 "KDM6A MUT" "GSK.650394_IC_50" 0.499083121030761 0.845109283443017 -0.312654145426518 0.94207499415845 0.994588914724909 -0.0218394406733719 0.315884604006644 0.900294798053993 -0.489020468375048 "NOTCH1 MUT" "TW.37_IC_50" 0.823722150721575 0.957177484110155 -0.150967301801803 0.942107980890756 0.994588914724909 0.0444363781029253 0.808231113143434 0.977383317127464 -0.156266179972573 "CCND1 MUT" "AZ628_IC_50" 0.178466680007759 0.657660823713238 1.16617961888111 0.942252309398 0.994588914724909 0.0478232620426663 0.814884514884005 0.977383317127464 0.207935658623006 "TSC1 MUT" "X17.AAG_IC_50" 0.386733234883458 0.79929668582732 1.34544802857146 0.942497654049571 0.994588914724909 0.0987646611994389 0.472724850911418 0.929276781658587 0.978747116597074 "NF2 MUT" "Cyclopamine_IC_50" 0.74903048409133 0.932323030730707 -0.152159225352113 0.942519833437269 0.994588914724909 0.0325035688809651 0.86582865612958 0.987077901072027 -0.0884916912372022 "FGFR3 MUT" "NVP.TAE684_IC_50" 0.202227839508719 0.674012093366938 -2.21818149664427 0.942714878523729 0.994588914724909 -0.102266585526456 0.35657111524812 0.91161229252998 -1.61261466036037 "MSH2 MUT" "Methotrexate_IC_50" 0.468443973235138 0.831405016816516 -0.659544060606052 0.942718757778146 0.994588914724909 -0.0497894246917131 0.620882735032265 0.950496524771391 0.357596286132452 "MET MUT" "Bosutinib_IC_50" 0.272421296397324 0.734000646544246 0.575676662135918 0.942767605776078 0.994588914724909 -0.0310009487044926 0.605022762249493 0.949657634568742 0.250890825766923 "FLT3 MUT" "X17.AAG_IC_50" 0.412781696762942 0.812480994891775 1.0405051431298 0.94287226538666 0.994588914724909 0.080746563310496 0.699524576263548 0.961100601384891 0.432568360235243 "CDKN2a(p14) MUT" "PAC.1_IC_50" 0.667808688526146 0.905919726780999 -0.0642916922313616 0.94312863370603 0.994588914724909 -0.00937993664515415 0.611155028908467 0.949930222127033 -0.0819511286974265 "CCND1 MUT" "RDEA119_IC_50" 0.781121870355343 0.943700629931411 -0.133312664730292 0.9431520757556 0.994588914724909 0.0311651532488677 0.821975790804053 0.977630507316298 0.0997992979564183 "ALK MUT" "Methotrexate_IC_50" 0.725432551387934 0.924863965058017 -0.551267665330671 0.943184011217305 0.994588914724909 0.0854851546674308 0.93050590270271 0.99422596912377 0.109132096190967 "KIT MUT" "Cytarabine_IC_50" 0.315216239897411 0.760537253034044 -0.999620836190483 0.943185208851839 0.994588914724909 0.054055119371508 0.482778018000378 0.931671355467483 -0.651940519201079 "NF1 MUT" "GSK.650394_IC_50" 0.0594273490159023 0.439862785571841 0.833526464762205 0.9433559418812 0.99464567482944 -0.0204505451738505 0.209268917881623 0.853446327418758 0.598572795363615 "TSC1 MUT" "PD.0325901_IC_50" 0.412927113964338 0.812587125884619 1.30285919405942 0.94347198540914 0.99464567482944 0.106486384380517 0.39951848172361 0.916480913435499 1.17176283003461 "VHL MUT" "KU.55933_IC_50" 0.660102457095132 0.902400992643984 -0.196689745508978 0.943575026510307 0.99464567482944 0.0283130724705353 0.585090203062212 0.949294892873838 0.260889158802037 "FBXW7 MUT" "A.770041_IC_50" 0.594407028609584 0.878503714608374 -0.437917271777006 0.943778399208228 0.994736364005961 0.0481251520491446 0.579616442029223 0.949294892873838 -0.447719259760531 "PTEN MUT" "Metformin_IC_50" 0.346795644571205 0.782020929432191 -0.168835593818984 0.944216790633137 0.994736364005961 -0.0119902474266731 0.0507128045627592 0.687603690567731 -0.372937487087723 "MDM2 MUT" "Imatinib_IC_50" 0.926003387299789 0.98643792569589 0.0582585374149663 0.944303671017745 0.994736364005961 -0.0432339110315584 0.891765225549716 0.988301482344111 0.0903396586111971 "BRCA1 MUT" "Pyrimethamine_IC_50" 0.718452331730805 0.92132587844031 0.594648847457626 0.944431901717316 0.994736364005961 0.0970296957503734 0.655951550354815 0.958313128388245 0.746445738827408 "GNAS MUT" "S.Trityl.L.cysteine_IC_50" 0.387446653556217 0.799604240186033 -1.04591923663253 0.944569991184728 0.994736364005961 0.0460017009038498 0.74122659995651 0.96672489654949 -0.409363535056891 "NF2 MUT" "BI.D1870_IC_50" 0.665288610272855 0.904120604106079 0.151622215841583 0.94460168267521 0.994736364005961 0.0212338318967442 0.576632263487771 0.949294892873838 0.19819906737795 "PIK3CA MUT" "AICAR_IC_50" 0.762551438932757 0.936064732612588 0.0757479986822603 0.944719440678697 0.994736364005961 -0.0157496373169123 0.846192745632107 0.98378870157398 0.0513670641279414 "CDH1 MUT" "GW.441756_IC_50" 0.799940713143896 0.950404478050962 0.109817626679461 0.944766256669907 0.994736364005961 -0.0297275533636436 0.735172297669918 0.96672489654949 0.156275484533455 "CDH1 MUT" "VX.680_IC_50" 0.751329200159272 0.932940664991998 0.37575465635739 0.944766713572375 0.994736364005961 -0.0547901590163076 0.915367605968681 0.991871609151764 0.133431101690492 "PDGFRA MUT" "AG.014699_IC_50" 0.559398385039617 0.869446457391816 -0.3774399751693 0.944884972402192 0.994736364005961 0.0394146383815722 0.94286733365696 0.995314665488626 -0.0435729609770855 "VHL MUT" "BMS.708163_IC_50" 0.703331070877256 0.915500829364901 0.164888683257918 0.944924543078856 0.994736364005961 0.0303415752679292 0.770355879246795 0.969901216545994 0.13836962674404 "MLL_AFF1 MUT" "S.Trityl.L.cysteine_IC_50" 0.318787574867087 0.761267128904167 -1.47483715306123 0.945097279670839 0.994736364005961 0.0567261408280552 0.281087550513393 0.887872038823822 -1.62959593321516 "SETD2 MUT" "NVP.TAE684_IC_50" 0.885854754664798 0.974449243426767 -0.250035523489929 0.945117153415415 0.994736364005961 0.0994184898940282 0.904542957706553 0.988828902928594 0.211646787202239 "KDR MUT" "Elesclomol_IC_50" 0.527383015202676 0.855121165130409 -0.796919311153363 0.945304743600479 0.994800714379007 -0.0718908602201577 0.846763070742576 0.98378870157398 0.232665735828139 "SMARCA4 MUT" "MG.132_IC_50" 0.887433017334482 0.975214727041194 -0.194210101694915 0.945402322864409 0.994800714379007 0.0830917729452098 0.673289683018285 0.960256725054738 0.923793463433695 "MLLT3 MUT" "Pazopanib_IC_50" 0.595099775203314 0.878837476080544 -0.222584822456323 0.945886651697837 0.995055356519428 -0.0240518137477232 0.662342971266872 0.958689538788368 -0.174504235290644 "MAP2K4 MUT" "CEP.701_IC_50" 0.626722690922831 0.89123540333742 0.262210718568668 0.945959435849404 0.995055356519428 -0.026834715389415 0.540542697260667 0.944806105261359 -0.331226543894509 "MAP2K4 MUT" "GDC0941_IC_50" 0.593327590072111 0.878261059495448 0.283450888888888 0.945980449847262 0.995055356519428 0.0289533991957624 0.686590472451054 0.961100601384891 -0.235573206863539 "KDM5C MUT" "IPA.3_IC_50" 0.729900060485915 0.927541495579058 0.357567907504369 0.946182315534547 0.995095319608851 0.0587480767378121 0.420429465219829 0.922428741067589 0.7725821766737 "NF2 MUT" "Bryostatin.1_IC_50" 0.424755563637325 0.818939554001493 -0.223630990407676 0.946297976232675 0.995095319608851 -0.0179575106569965 0.847940604828104 0.98378870157398 -0.0553534662362905 "TP53 MUT" "X681640_IC_50" 0.435227812083018 0.823150425912549 0.121484822175963 0.946354585003531 0.995095319608851 -0.00942395560375768 0.943875957079917 0.995317308813434 -0.0110592104084503 "KDM6A MUT" "Obatoclax.Mesylate_IC_50" 0.750287981276433 0.932697982453688 -0.162943962144571 0.946752794640411 0.995295615397285 -0.0252545917864527 0.758255751672149 0.969901216545994 0.160103570549196 "VHL MUT" "PD.0332991_IC_50" 0.901540104381476 0.979694707150557 -0.086929425365348 0.946922454175003 0.995295615397285 -0.0375501169987091 0.968926551787921 0.997173634484198 -0.0278222855025672 "PTEN MUT" "MS.275_IC_50" 0.959673685697882 0.993456347206305 0.0173522633980418 0.947016688614438 0.995295615397285 -0.0192336448556883 0.725373513739993 0.965402608571648 0.137648541178171 "VHL MUT" "NVP.TAE684_IC_50" 0.861681946982571 0.966384100200122 -0.192907749152542 0.947020534310492 0.995295615397285 -0.0610244108707571 0.767430975183146 0.969901216545994 0.384086748716729 "EWS_FLI1 MUT" "KIN001.135_IC_50" 0.996794267409471 0.998981694467749 0.000959280303029987 0.947105421205096 0.995295615397285 -0.0168334694334333 0.340251592408488 0.907167334788287 -0.245066759927784 "KRAS MUT" "LFM.A13_IC_50" 0.682320116097528 0.909924137549646 -0.0539679650160132 0.947270248140001 0.995351049897226 0.00866495161638337 0.75372254538082 0.96913420088708 -0.0471141256484564 "KRAS MUT" "Nilotinib_IC_50" 0.0923632133690622 0.520483603614995 0.324508695942042 0.947755060450107 0.995582022721441 0.0108510982602026 0.315202068196202 0.900294798053993 0.202536537695908 "PIK3R1 MUT" "AZD6482_IC_50" 0.524615219823752 0.854725328793752 0.475653175403737 0.947773678676745 0.995582022721441 -0.0413108800882894 0.600536525315644 0.949657634568742 0.380903549594726 "AKT2 MUT" "Nilotinib_IC_50" 0.598252788882386 0.879232253518807 0.354419891013384 0.947826371141739 0.995582022721441 0.0356453982844735 0.940637452185151 0.995120990231635 0.0454210607215284 "TET2 MUT" "ABT.888_IC_50" 0.0871581342751817 0.509244335853874 -1.04568099363871 0.947988344995166 0.995598614634047 0.0341769172555086 0.958852291684801 0.99641548698706 0.0363439254636466 "TP53 MUT" "Elesclomol_IC_50" 0.401836727572911 0.806488582502829 0.168208982473037 0.948066375854086 0.995598614634047 0.0113479730683525 0.403213240141273 0.917013261381471 0.170236032578358 "FAM123B MUT" "BIBW2992_IC_50" 0.775574426399771 0.941591338606299 0.271368957142861 0.948469371977075 0.995662560618248 0.0590856529186817 0.539970035511113 0.944569766818715 0.547060842863283 "IDH1 MUT" "CI.1040_IC_50" 0.61965226899786 0.887556792488111 -0.62872490648856 0.948491622687339 0.995662560618248 -0.0728900680321225 0.572162058489715 0.949294892873838 -0.634849517037941 "CTNNB1 MUT" "Doxorubicin_IC_50" 0.179967688106771 0.658614416960816 -0.683532195136424 0.948552336980751 0.995662560618248 0.0205010580773789 0.408348612008335 0.920903133902018 -0.450918864518444 "CCND1 MUT" "LFM.A13_IC_50" 0.796271015944107 0.949219180214713 0.0562829090909088 0.9486029868304 0.995662560618248 -0.0133487511193918 0.82425717750114 0.979163723032052 -0.0516898245715 "EP300 MUT" "AZD.0530_IC_50" 0.460648730473391 0.828966839128293 -1.05791245454544 0.948809660879777 0.995662560618248 -0.0794620282008598 0.871531422895516 0.987631819157213 0.218473900068812 "FGFR2 MUT" "Bosutinib_IC_50" 0.429643924758847 0.820918238409269 1.00533358285716 0.948961251802616 0.995662560618248 0.0673905390960106 0.216719517696995 0.860576337437605 2.051814156451 "BRCA1 MUT" "Sorafenib_IC_50" 0.836084277584146 0.959122768755193 0.271602715254236 0.949035502363212 0.995662560618248 0.0795802946517558 0.575777889500128 0.949294892873838 0.766370074557103 "TP53 MUT" "NVP.TAE684_IC_50" 0.911379195630901 0.982267477694927 0.0329337757009355 0.949230736199953 0.995662560618248 -0.016643797413553 0.908485903393704 0.989534075687441 0.0374002879327372 "SOCS1 MUT" "CEP.701_IC_50" 0.514175415302362 0.85130999259055 -0.853224652751417 0.949250105104643 0.995662560618248 -0.061078347007421 0.527428993436669 0.942617761067065 -0.748641093684122 "MDM2 MUT" "CGP.082996_IC_50" 0.943627744417928 0.990147156460271 -0.0521695189003431 0.949304787111593 0.995662560618248 -0.0393990955667655 0.746080564537418 0.968371047127272 0.23643724989565 "KDM5C MUT" "RO.3306_IC_50" 0.738714276208259 0.929570057037101 -0.283873633398566 0.94947980295913 0.995662560618248 0.0513577716551885 0.802385708111098 0.976365695720597 -0.211377545417859 "FLCN MUT" "RDEA119_IC_50" 0.756549107903759 0.934762260113025 0.364005980119287 0.949552699123351 0.995662560618248 -0.0671586531612615 0.722620779544468 0.965402608571648 -0.502465806710213 "TET2 MUT" "Cisplatin_IC_50" 0.211058446584689 0.684851815382059 -1.19985940494295 0.949754570661315 0.995662560618248 0.0530157849074979 0.887412247725465 0.988301482344111 -0.16016686967254 "MYC MUT" "GW.441756_IC_50" 0.425569769620264 0.819381892124907 0.15754906842263 0.949944015414091 0.995662560618248 0.0122123245884921 0.256215911039436 0.875707386589409 0.23278403250342 "CCND1 MUT" "WH.4.023_IC_50" 0.640446038574583 0.895951701992251 0.488739551643191 0.950551509983738 0.995662560618248 -0.0575250319895596 0.40094545653299 0.916589616820582 0.953448968337115 "MYCN MUT" "Mitomycin.C_IC_50" 0.883205901951088 0.973927829424842 -0.0740885071813288 0.950659682397549 0.995662560618248 -0.0250545465797797 0.161669747746099 0.839927262232576 -0.795341090637582 "GNAS MUT" "VX.680_IC_50" 0.617513983747432 0.886326305706232 -0.761745612059153 0.9507328970096 0.995662560618248 -0.0613925113399731 0.611854170677709 0.949930222127033 -0.803896539395592 "NRAS MUT" "ATRA_IC_50" 0.470233914128335 0.832012966658205 -0.212338397999225 0.950754508055149 0.995662560618248 -0.0148481224788472 0.639771443580035 0.954844169357195 0.137523021851552 "FLCN MUT" "Sunitinib_IC_50" 0.319239826022195 0.761311064402907 1.36146078612059 0.9510026876617 0.995662560618248 -0.0618504002445137 0.861477029511782 0.985524480087535 -0.368297254636103 "EP300 MUT" "Thapsigargin_IC_50" 0.76563268163349 0.936968974174869 -0.496525134727057 0.951519797463955 0.995662560618248 0.0776114262165354 0.81388097633266 0.977383317127464 -0.378990310024717 "SMARCA4 MUT" "NVP.BEZ235_IC_50" 0.947760317419517 0.990899019819731 -0.0322943575757576 0.951654491660699 0.995662560618248 -0.0214561983361768 0.723903076432759 0.965402608571648 0.188768077693305 "KDR MUT" "GDC.0449_IC_50" 0.711432788589754 0.919312211985394 0.261724442295294 0.951663122575037 0.995662560618248 0.0382355371520258 0.672319809210189 0.960256725054738 0.299681935960898 "MLL_AFF1 MUT" "AMG.706_IC_50" 0.102816295348474 0.543688489044222 -1.48023416015623 0.951761342687743 0.995662560618248 -0.0514785301137301 0.275496563017931 0.883780956691668 -0.923991036179968 "CDKN2a(p14) MUT" "WO2009093972_IC_50" 0.210304301544792 0.684261946425694 -0.188687224620514 0.95177810603311 0.995662560618248 -0.00845919902363793 0.894155721576932 0.988301482344111 0.0220442806122666 "FGFR3 MUT" "Nilotinib_IC_50" 0.892036413594445 0.975972789421281 0.157545641366221 0.951803157564479 0.995662560618248 -0.0567826933660334 0.571871409851712 0.949294892873838 -0.588332816637237 "AKT2 MUT" "X681640_IC_50" 0.516527110229757 0.852353345422823 0.475463065306118 0.9519475706423 0.995662560618248 -0.0377583366663967 0.763538233064065 0.969901216545994 0.208988804253679 "MAP2K4 MUT" "GDC.0449_IC_50" 0.372489607091194 0.792043637967351 0.331979562421858 0.952092194160835 0.995662560618248 -0.0199437242654851 0.899769881028043 0.988704788932507 0.0493178141498249 "MLH1 MUT" "CGP.60474_IC_50" 0.278741411123387 0.736963633230962 0.721407402777774 0.952161609063794 0.995662560618248 -0.0301144541666698 0.306230730634495 0.896682870760742 0.673726338493963 "MLLT3 MUT" "FTI.277_IC_50" 0.460093532402588 0.828966839128293 -0.176876534740258 0.952265654193629 0.995662560618248 -0.0129943326653956 0.980749225843229 0.997827228172038 -0.00571748095057368 "CCND2 MUT" "BAY.61.3606_IC_50" 0.74012387953325 0.929570057037101 0.367015814169567 0.952333718546604 0.995662560618248 0.0456713389810152 0.629224953304033 0.952523560833852 0.612845601396726 "FGFR2 MUT" "PLX4720_IC_50" 0.716326218809336 0.921183485265814 0.486607816443594 0.952445524827149 0.995662560618248 0.071400957118912 0.950040230468878 0.995668765770473 -0.107318665057254 "KIT MUT" "EHT.1864_IC_50" 0.963703351111812 0.994159243759316 0.0289084080717494 0.952465888094949 0.995662560618248 0.0377767219825758 0.950823871467108 0.995668765770473 -0.0383892354630335 "FGFR2 MUT" "Sorafenib_IC_50" 0.604115384080972 0.881814764520839 0.556562248299321 0.952481370257423 0.995662560618248 0.0621289354448575 0.738936001991994 0.96672489654949 -0.449755045110382 "FLT3 MUT" "Docetaxel_IC_50" 0.301344420304439 0.751119785777076 1.08112272340426 0.952502275180986 0.995662560618248 0.0473818057741012 0.374244579301968 0.913948248824328 0.899478349276009 "MYCL1 MUT" "AZD.0530_IC_50" 0.497088812684079 0.844812404817149 0.566052802047784 0.952808112814507 0.995662560618248 0.0432332551002415 0.420224646538116 0.922428741067589 -0.659102545890192 "VHL MUT" "Bicalutamide_IC_50" 0.375073810049188 0.794616056070335 -0.195836656414762 0.952810648092105 0.995662560618248 -0.0125021377298742 0.736326039671775 0.96672489654949 -0.0755347043431541 "MDM2 MUT" "Epothilone.B_IC_50" 0.32413318253911 0.765579672794663 0.73389270899471 0.952865648723456 0.995662560618248 -0.0250284134075986 0.302934411108985 0.894219632947544 0.745520673960696 "RB1 MUT" "GDC.0449_IC_50" 0.428349272018708 0.820918238409269 -0.137959904203325 0.953206424974956 0.995662560618248 -0.00938931928059137 0.248804328707464 0.875707386589409 -0.218374651094767 "CTNNB1 MUT" "GSK269962A_IC_50" 0.711156087653876 0.919312211985394 -0.353038694158078 0.95322133391809 0.995662560618248 0.0518290880785813 0.916734272967982 0.992403322408462 -0.110467315350633 "NF1 MUT" "TW.37_IC_50" 0.74249739027202 0.929570057037101 0.0949058449104868 0.953302672977509 0.995662560618248 -0.0153894564993148 0.539416964125613 0.944569766818715 0.180480680176716 "RB1 MUT" "MK.2206_IC_50" 0.794891705314487 0.948646027682356 0.0686878149397372 0.953627618991297 0.995662560618248 -0.0126255241175473 0.578698500575682 0.949294892873838 0.159543372025799 "MSH6 MUT" "EHT.1864_IC_50" 0.951558425605107 0.992342693494476 -0.0385915919282511 0.953647951182391 0.995662560618248 0.0365770908674402 0.87069404933968 0.98753907730331 0.100384706010137 "FGFR3 MUT" "CCT018159_IC_50" 0.902581761587224 0.979694707150557 0.122710730593609 0.95364877682869 0.995662560618248 0.054308593740982 0.895410166046498 0.988301482344111 0.132606779238174 "EZH2 MUT" "Rapamycin_IC_50" 0.332874299330254 0.773185226006147 1.46932229391893 0.953677282188352 0.995662560618248 0.0756463280970786 0.120644465860766 0.80757178183218 2.73342871637003 "AKT2 MUT" "Bicalutamide_IC_50" 0.906748413581431 0.981251818741413 -0.027633443609023 0.953710068871957 0.995662560618248 0.0130080991519865 0.908167183004756 0.989534075687441 0.0258091593661621 "CTNNB1 MUT" "OSI.906_IC_50" 0.562912775060026 0.871238675201477 -0.308459297746148 0.953813849730337 0.995662560618248 0.0292207850483972 0.402279661283221 0.916823093416154 -0.503803856795106 "CCND2 MUT" "Thapsigargin_IC_50" 0.684672884637547 0.91081184668455 0.676399929152141 0.953912031223816 0.995662560618248 -0.0730066291848856 0.743663728677076 0.967122210335498 0.646629397300433 "TET2 MUT" "Sorafenib_IC_50" 0.790772025505227 0.94790644179192 -0.28483673129252 0.954184925915953 0.995662560618248 -0.0593401062675366 0.841613897538737 0.982306876598965 -0.269511845096517 "MLLT3 MUT" "A.770041_IC_50" 0.876837952840651 0.971594429690931 -0.127489042857143 0.954293745962479 0.995662560618248 0.0380463830901647 0.99471752040631 0.999545005862799 0.00545639675120883 "MLH1 MUT" "Nilotinib_IC_50" 0.421235710927834 0.815993951252625 -0.401396615830113 0.954404184890826 0.995662560618248 0.0233889117002367 0.73687702039424 0.96672489654949 0.152164633978325 "CCND1 MUT" "BMS.509744_IC_50" 0.305659478476966 0.754673847193199 0.522456649122808 0.954528645853245 0.995662560618248 0.0220026316323465 0.577691818324363 0.949294892873838 0.324487171264657 "NF1 MUT" "Midostaurin_IC_50" 0.243042470648764 0.712490868125953 0.473833292370125 0.954792740744541 0.995662560618248 0.0178574224155443 0.742534213523019 0.966725278648091 0.131224584990099 "CDKN2a(p14) MUT" "Cisplatin_IC_50" 0.215800957269191 0.688608753079032 -0.183544713734218 0.954885361701289 0.995662560618248 0.00756454080927456 0.322717640152544 0.900918773778407 0.156823535992942 "CDKN2C MUT" "X681640_IC_50" 0.654914266747424 0.901074441039429 0.259803248459959 0.955016696300966 0.995662560618248 0.0281231648602668 0.714435394319131 0.962630898212352 0.213865083500392 "CCND2 MUT" "Bryostatin.1_IC_50" 0.808100233053298 0.952641225877339 0.177234589430893 0.95528317220353 0.995662560618248 -0.0383349418696153 0.260740432907521 0.877052916121269 -0.957390749478353 "FGFR2 MUT" "Elesclomol_IC_50" 0.445386795894593 0.825606373270691 1.17729777798861 0.955637218429193 0.995662560618248 0.0719650337214127 0.122667976784393 0.810576117427226 3.17091069777317 "EZH2 MUT" "A.770041_IC_50" 0.107205218815507 0.551794991672845 2.06915989078498 0.955748829198419 0.995662560618248 -0.0582586122361469 0.201313807289571 0.851001889249827 1.78900054528304 "CDK6 MUT" "Vinorelbine_IC_50" 0.466845528409444 0.830828665219814 0.49483770506108 0.956004703181633 0.995662560618248 -0.0275352928811241 0.356983571526681 0.91161229252998 0.651349612893494 "MYCL1 MUT" "Camptothecin_IC_50" 0.974916341223509 0.996000463177958 0.0251716132437619 0.956016221533525 0.995662560618248 -0.0278710079067624 0.687244460244001 0.961100601384891 0.311623899221177 "RB1 MUT" "AMG.706_IC_50" 0.995260276154773 0.998977896287767 0.00109581561996701 0.956083939091876 0.995662560618248 0.00960940390620692 0.589670519316894 0.949294892873838 -0.101679360132051 "FGFR3 MUT" "Methotrexate_IC_50" 0.861282786901064 0.966384100200122 0.274292985971949 0.956218438602729 0.995662560618248 0.0654929768930025 0.562033271997644 0.949294892873838 -0.718977592207296 "AKT2 MUT" "QS11_IC_50" 0.321055385268513 0.762015213745527 -0.739723415789478 0.956230598127921 0.995662560618248 0.0300366203901775 0.244800491103244 0.875707386589409 -0.856298556482986 "BRCA2 MUT" "FH535_IC_50" 0.61545846143396 0.885815598771911 0.32769264214828 0.956268376125897 0.995662560618248 0.0308285159645638 0.530305617650171 0.94320946427311 0.395756622852886 "SETD2 MUT" "PAC.1_IC_50" 0.280579663682958 0.737882141891724 1.31861764173914 0.95636713710021 0.995662560618248 0.0563479430157756 0.552069657075881 0.947060194029534 0.701529748301282 "TET2 MUT" "FH535_IC_50" 0.313738372975576 0.759626633150515 0.926711684668979 0.95638250895464 0.995662560618248 0.0436887046577565 0.970338312038334 0.997173634484198 0.040146690446217 "NOTCH1 MUT" "CHIR.99021_IC_50" 0.439787337186871 0.824500931653809 0.280929249116603 0.956383392247549 0.995662560618248 0.0194569321822781 0.87283035841605 0.987739302532152 0.0619323565929059 "CDH1 MUT" "BMS.509744_IC_50" 0.41643092134903 0.814099702076568 0.634548253424654 0.956398791744113 0.995662560618248 -0.0324174051961221 0.506317183708673 0.935912793170426 0.522833161678908 "HRAS MUT" "AICAR_IC_50" 0.519223299411418 0.852599738673405 0.453820467836259 0.956444015059566 0.995662560618248 -0.0345287503253728 0.67191527288136 0.960256725054738 0.286286244366146 "FLT3 MUT" "OSI.906_IC_50" 0.734521479377833 0.928710633005918 -0.346798239092502 0.956703957331379 0.995662560618248 0.0530740857732188 0.555648092412267 0.948071221654821 -0.609370773734053 "BRCA1 MUT" "GDC.0449_IC_50" 0.539463327197905 0.861530985226506 0.376292383720931 0.956785707523399 0.995662560618248 0.0296749489487648 0.645842330719935 0.957070872538585 0.278266659469399 "GNAS MUT" "Epothilone.B_IC_50" 0.468948882287439 0.831812685952708 0.539129462786593 0.956871834983785 0.995662560618248 -0.0229173540362034 0.520888963310691 0.939635632721979 0.469843960948568 "KIT MUT" "AZD.2281_IC_50" 0.931546762300737 0.986689293492114 -0.0645670849802373 0.956948894433211 0.995662560618248 0.0306935730901837 0.780055779910157 0.972337708041191 -0.186074712114643 "JAK2 MUT" "TW.37_IC_50" 0.587468182653611 0.876506729771444 0.278833827664402 0.957046805860496 0.995662560618248 0.0252688814422394 0.977090535081393 0.99742775226181 -0.0153991662105519 "NF1 MUT" "Bleomycin_IC_50" 0.192170749968256 0.668023137615267 0.914690046303571 0.957086801990983 0.995662560618248 -0.0310214972204955 0.921971732112158 0.993931766508607 0.0716782403891375 "CDKN2a(p14) MUT" "Bexarotene_IC_50" 0.0179089168245617 0.245008564936728 -0.329258323501761 0.957132179283644 0.995662560618248 0.00699134398094171 0.721055740084284 0.965402608571648 0.0530574035241301 "SETD2 MUT" "GSK.650394_IC_50" 0.348063534972963 0.783164999770683 1.38275213565219 0.957222664175059 0.995662560618248 0.0513679155587577 0.392502910103381 0.915926348152589 1.25553833025904 "NOTCH1 MUT" "WZ.1.84_IC_50" 0.972077226962493 0.995220468612913 0.0180213141945767 0.957260012760335 0.995662560618248 0.0239906712878994 0.708300928740852 0.962630898212352 -0.211113501797603 "TET2 MUT" "AKT.inhibitor.VIII_IC_50" 0.980521057859678 0.996332002460735 -0.0226320051813475 0.957260923787977 0.995662560618248 -0.0431261297066145 0.79583454805546 0.976216384154771 0.28714578537558 "CCND2 MUT" "AKT.inhibitor.VIII_IC_50" 0.974291648968648 0.995601684471241 0.0298719671848016 0.957263313291612 0.995662560618248 0.0423684752828013 0.622753049507146 0.950496524771391 0.544283949277047 "EZH2 MUT" "S.Trityl.L.cysteine_IC_50" 0.100527582475759 0.539275980611557 1.72131396232877 0.957395674950291 0.995662560618248 -0.0305540938103195 0.0221574161243049 0.552752844381886 2.79096245577101 "BRCA2 MUT" "Bryostatin.1_IC_50" 0.546257868609455 0.86289571535809 0.31211532574431 0.95761926594413 0.995662560618248 -0.026060137890209 0.466656401993923 0.929276781658587 0.36326099646784 "FLT3 MUT" "JNK.9L_IC_50" 0.339994463835163 0.778500909061878 -0.657290896193771 0.9576327764223 0.995662560618248 -0.02889264149443 0.651396724737475 0.958313128388245 -0.310878943480863 "SMARCA4 MUT" "Epothilone.B_IC_50" 0.675443946488287 0.908552538148308 0.297498046900098 0.957905058439591 0.995662560618248 0.021240090099499 0.724529113217956 0.965402608571648 0.274537592797587 "IDH1 MUT" "NU.7441_IC_50" 0.998414853903121 0.999548905963057 -0.00201385798816623 0.957929070494909 0.995662560618248 0.0466772973639206 0.799638489227661 0.976360691959787 0.249319309879371 "KDM6A MUT" "BI.D1870_IC_50" 0.20222237757967 0.674012093366938 -0.491825399257803 0.957944616377822 0.995662560618248 0.017734039318692 0.023157684587223 0.563461361148295 -0.854850739973484 "STK11 MUT" "Erlotinib_IC_50" 0.444465948429842 0.825606373270691 -0.593138029411766 0.957977054227934 0.995662560618248 -0.0370082566427703 0.877746316594412 0.987867828877832 -0.132893401570531 "ALK MUT" "S.Trityl.L.cysteine_IC_50" 0.501301801772541 0.846334637471348 0.706142934931507 0.957990460115039 0.995662560618248 0.0302595825014263 0.867810955236272 0.987342922214615 -0.208050963398514 "MLH1 MUT" "Obatoclax.Mesylate_IC_50" 0.382829813258516 0.798569876743396 -0.58617344631269 0.958119372416436 0.995662560618248 0.0263003084478196 0.91422116535421 0.990992087087848 -0.0698964395647958 "MLLT3 MUT" "Paclitaxel_IC_50" 0.943798576528958 0.990147156460271 0.0590646132404186 0.958180575664461 0.995662560618248 -0.019183966764221 0.968952459638357 0.997173634484198 -0.0343557109692702 "APC MUT" "WH.4.023_IC_50" 0.980504536092288 0.996332002460735 -0.0266648338118015 0.958259523244161 0.995662560618248 -0.0513407638103362 0.870648264871662 0.98753907730331 -0.19666992081757 "MYCN MUT" "Vinorelbine_IC_50" 0.555112728397811 0.867339222537114 0.278674059549409 0.958359764982453 0.995662560618248 -0.0185231031772379 0.466241479002506 0.929276781658587 -0.390363438478393 "BCR_ABL MUT" "BX.795_IC_50" 0.18116377612542 0.658636992153339 -1.23597386612574 0.958961150276353 0.995662560618248 -0.0478849006207219 0.889764379533686 0.988301482344111 -0.116171460096165 "SMAD4 MUT" "BMS.509744_IC_50" 0.175534196379443 0.65398734404354 -0.896169064039405 0.959117487938432 0.995662560618248 -0.025836738186101 0.169733138376274 0.84067330207935 -0.94348568135914 "BRCA2 MUT" "JNK.Inhibitor.VIII_IC_50" 0.587029029588067 0.876506729771444 0.278808505747125 0.959382230050652 0.995662560618248 -0.0251854865320001 0.927765407527528 0.994186152404781 -0.0473340401633202 "PDGFRA MUT" "AUY922_IC_50" 0.605497110233619 0.882603260686518 -0.439253652097903 0.959487932106508 0.995662560618248 -0.0290359369209651 0.947556259378427 0.995668765770473 0.0543308966159304 "CCND1 MUT" "GW843682X_IC_50" 0.888026291811974 0.975214727041194 0.101188798245615 0.959719805660685 0.995662560618248 -0.0191231193901289 0.771713920378311 0.969901216545994 0.251196165827789 "PTEN MUT" "DMOG_IC_50" 0.63209354543638 0.893900814662562 -0.0996156879136197 0.959774887837015 0.995662560618248 0.00965043454093758 0.929285839677803 0.99422596912377 0.0189664642397476 "CDKN2A MUT" "CCT007093_IC_50" 0.791278778316878 0.94790644179192 0.0252765563123709 0.960003988695188 0.995662560618248 -0.00498085826597071 0.759418606453739 0.969901216545994 -0.0335394796557329 "FGFR3 MUT" "Paclitaxel_IC_50" 0.187481056738816 0.663090109477269 -2.43206161355933 0.960036740934171 0.995662560618248 -0.0401517972944219 0.30203475296574 0.894167310052 -1.90668047974584 "MYCN MUT" "BAY.61.3606_IC_50" 0.591690732564266 0.877518816093285 -0.233330975763014 0.960180768719524 0.995662560618248 0.0155372985475294 0.93340915922642 0.99465624694452 -0.0396033176574321 "SMAD4 MUT" "Obatoclax.Mesylate_IC_50" 0.561765421119705 0.870491471862243 -0.254603044487795 0.960441793476717 0.995662560618248 -0.0163882064214822 0.422547828979875 0.922428741067589 -0.362510854566309 "VHL MUT" "ABT.888_IC_50" 0.872501454945781 0.970405187398056 0.0604475934489395 0.96045831203858 0.995662560618248 -0.0158382537795002 0.799255767471176 0.976360691959787 -0.0971610460626099 "CCND1 MUT" "GNF.2_IC_50" 0.756550562037435 0.934762260113025 0.114540470657277 0.960508537927413 0.995662560618248 -0.0177894140101685 0.620839720489951 0.950496524771391 0.215943061098255 "CCND3 MUT" "ZM.447439_IC_50" 0.657483592609419 0.901751651084414 0.502017869140617 0.960626758339891 0.995662560618248 0.0444252598444745 0.674648497432292 0.960256725054738 0.446641335833258 "CCND3 MUT" "AZD8055_IC_50" 0.62245728379553 0.889024233867781 0.495162728712878 0.960834755681538 0.995662560618248 -0.0383255544755762 0.679202611184268 0.961100601384891 0.400264256567658 "SMAD4 MUT" "AUY922_IC_50" 0.21538305696039 0.688608753079032 -0.446709447709543 0.96095211932697 0.995662560618248 -0.0121679005267964 0.259489997076487 0.877052916121269 -0.417208194680489 "FLT3 MUT" "CGP.60474_IC_50" 0.205725959112075 0.678793564970003 -1.36398594311716 0.961053985329825 0.995662560618248 -0.039724696177776 0.351930504073163 0.91110953125066 -0.98433396866986 "EZH2 MUT" "CGP.60474_IC_50" 0.12857675847536 0.58914788070103 1.42023476712329 0.961069233378165 0.995662560618248 0.0339595087008486 0.0243936995856592 0.569786836641336 2.34251743737965 "TP53 MUT" "GW843682X_IC_50" 0.171504170962771 0.649721929411943 -0.403251733379431 0.961081735841561 0.995662560618248 0.00791924727008652 0.149788528996349 0.831473272394224 -0.484461239655087 "CDK6 MUT" "Vinblastine_IC_50" 0.24424999233763 0.713407040228131 0.698948357264951 0.961344728983834 0.995662560618248 0.0210077236832641 0.499895381960041 0.934042323734638 0.379717615996694 "ALK MUT" "CCT018159_IC_50" 0.825795955776603 0.957177484110155 -0.22065 0.961463341193327 0.995662560618248 0.0451945185116533 0.72173935927469 0.965402608571648 -0.365779436283318 "MSH6 MUT" "MK.2206_IC_50" 0.616165574058194 0.885815598771911 -0.367617930699931 0.961627626177438 0.995662560618248 0.0281533700361997 0.761591711672684 0.969901216545994 -0.215492467996133 "EZH2 MUT" "GW.441756_IC_50" 0.860515211470565 0.966384100200122 0.0960421393129784 0.961727248902854 0.995662560618248 -0.0255823761032655 0.92217640345268 0.993931766508607 -0.0528128030574514 "FGFR2 MUT" "Docetaxel_IC_50" 0.305234258662903 0.754224310561809 1.31223252509652 0.961730131597156 0.995662560618248 -0.0463693104228973 0.119994934803562 0.80757178183218 2.70283760965224 "FGFR3 MUT" "Pazopanib_IC_50" 0.494156790987963 0.843282996121548 -0.745578879790932 0.961953796290975 0.995662560618248 -0.044225614596573 0.456993441812935 0.925841766232465 -0.738623762185658 "MDM2 MUT" "CCT007093_IC_50" 0.974423793907485 0.995611794028115 0.0103745454545452 0.96196825502922 0.995662560618248 -0.0154430828033263 0.865101934898174 0.987077901072027 0.0554317030564352 "MAP2K4 MUT" "Methotrexate_IC_50" 0.184768091776046 0.660550500647272 0.895009362708723 0.962008683670209 0.995662560618248 -0.024517709277774 0.820353413013609 0.977383317127464 0.128999761198131 "KDR MUT" "CI.1040_IC_50" 0.861465914629481 0.966384100200122 0.180679507329511 0.962155234640304 0.995662560618248 0.0439351267157168 0.748549618339098 0.968780465757047 0.295668238162161 "PIK3R1 MUT" "Nilotinib_IC_50" 0.62025819387117 0.887671478437871 0.289185826295582 0.962177211229082 0.995662560618248 -0.0223954559236384 0.750223735596231 0.968780465757047 0.166537713819701 "MYCN MUT" "BIBW2992_IC_50" 0.551898184908499 0.865667216561706 0.263587862125903 0.962695935366876 0.995662560618248 0.0202039343687046 0.232862810187326 0.869962136993019 -0.572360262273601 "PIK3R1 MUT" "JNJ.26854165_IC_50" 0.529672400428411 0.856477574579742 0.272698231292521 0.962707693133894 0.995662560618248 -0.0188977973412766 0.904895835309087 0.988849503307494 -0.0491247769830521 "FAM123B MUT" "AMG.706_IC_50" 0.845701509170408 0.961427944565079 0.144502237442924 0.962786169910113 0.995662560618248 0.0319109098301249 0.804576150089726 0.976878758490379 -0.170516670633211 "CDKN2A MUT" "Etoposide_IC_50" 0.0371167470088146 0.351296460573821 -0.426931850790552 0.962792606691579 0.995662560618248 0.00654155701233725 0.902594333930819 0.988746233284632 -0.0272645826914577 "MAP2K4 MUT" "GSK.650394_IC_50" 0.691189700470723 0.912932803156675 -0.231903316421164 0.962878856506078 0.995662560618248 -0.0175508256626883 0.665016307249225 0.959206771190239 -0.27667428741555 "NF1 MUT" "Rapamycin_IC_50" 0.250872466291735 0.717470497840808 1.01945711458334 0.962911883785433 0.995662560618248 -0.0357108721599971 0.799735423248078 0.976360691959787 0.263733881774229 "MSH6 MUT" "Metformin_IC_50" 0.369398026328699 0.789535578103719 -0.491663531669861 0.962995848932795 0.995662560618248 -0.0236803380213428 0.462733775711492 0.929276781658587 -0.392365857625079 "CDKN2C MUT" "CHIR.99021_IC_50" 0.932269664074706 0.98681842896288 0.0388969405594409 0.963103221361338 0.995662560618248 0.0201624864990856 0.173448092187539 0.844239622796781 0.716756474606575 "STK11 MUT" "XMD8.85_IC_50" 0.890398269537301 0.975801867105169 0.113167370242215 0.963105721840696 0.995662560618248 -0.0328679992297359 0.984178560866155 0.998124818853736 0.0182426515494723 "CTNNB1 MUT" "BMS.754807_IC_50" 0.273451344332075 0.734000646544246 -0.659258008896804 0.96311098500585 0.995662560618248 0.0232735852123443 0.5359868224111 0.943443271455699 -0.410633064461049 "TET2 MUT" "PF.02341066_IC_50" 0.574514905764399 0.872620551543038 -0.529725451178443 0.963282436191468 0.995662560618248 -0.0405047432954941 0.760675199848892 0.969901216545994 0.343862819410935 "NF2 MUT" "Thapsigargin_IC_50" 0.509602468483282 0.849059439813668 -0.42177506628983 0.963321747830575 0.995662560618248 -0.0226682831748 0.732145372955574 0.966676227971091 0.229377341655933 "MYCN MUT" "PHA.665752_IC_50" 0.775553787783899 0.941591338606299 0.0884072247823855 0.963377595856147 0.995662560618248 -0.0147778254101691 0.425183566068789 0.922428741067589 -0.304916235207769 "MLL_AFF1 MUT" "PF.02341066_IC_50" 0.452796955918383 0.828509891052426 -0.865951204697974 0.963522767463949 0.995662560618248 0.0498608724811393 0.96992569843525 0.997173634484198 -0.0428454840501927 "SMAD4 MUT" "Metformin_IC_50" 0.84453003180844 0.960588013894821 -0.0557946994899089 0.96369605683007 0.995662560618248 -0.0124043928380783 0.803162922565214 0.976532089774744 -0.0738491814422842 "SETD2 MUT" "Cyclopamine_IC_50" 0.97641181175782 0.996276778834563 -0.0310147260273986 0.963740431831339 0.995662560618248 -0.0444174623950282 0.991826235415664 0.999389382012633 -0.0108818203210262 "CTNNB1 MUT" "Paclitaxel_IC_50" 0.535419364203759 0.859514121743984 -0.665517219931276 0.963981675994837 0.995662560618248 0.0209295424912587 0.916752264051236 0.992403322408462 -0.124684983482823 "MDM2 MUT" "GSK.650394_IC_50" 0.291027143445324 0.746581806188469 0.700652253968252 0.964004005526132 0.995662560618248 0.0193419581378289 0.300151429778928 0.894167310052 0.682229665596672 "KIT MUT" "GNF.2_IC_50" 0.657016623836601 0.901751651084414 -0.394929840136055 0.964070317841666 0.995662560618248 -0.0398103611330963 0.669926181634028 0.95927684711462 0.388721097657988 "MYCL1 MUT" "Bicalutamide_IC_50" 0.653539255440438 0.900904870244158 0.0888153439153452 0.964088950044599 0.995662560618248 0.00847672398120123 0.573619911299077 0.949294892873838 0.113955053009318 "FBXW7 MUT" "Methotrexate_IC_50" 0.0870916266682673 0.509190741567401 -0.843837029464276 0.964122062869321 0.995662560618248 -0.0170955589880645 0.454884915560027 0.925809648901546 0.310885333166872 "SMO MUT" "Nilotinib_IC_50" 0.84911000750656 0.963526482778845 0.220834920303604 0.964155972615457 0.995662560618248 0.0420470152838926 0.648553795002571 0.957493413330814 -0.473799124801314 "PDGFRA MUT" "QS11_IC_50" 0.756306365023101 0.934762260113025 -0.273358089160841 0.964290216442574 0.995662560618248 -0.0289889941051626 0.673211450689838 0.960256725054738 -0.368529761653561 "SETD2 MUT" "AS601245_IC_50" 0.990737816801551 0.998036562927507 -0.0148123513043471 0.964492180250246 0.995662560618248 -0.0459692676699628 0.707584571216777 0.962630898212352 0.473517773802171 "TET2 MUT" "CI.1040_IC_50" 0.443119658129842 0.825539266593482 -0.793845285532197 0.964508196547698 0.995662560618248 -0.0415992518616276 0.77031093355087 0.969901216545994 -0.327844633592778 "EZH2 MUT" "Bosutinib_IC_50" 0.9767114922226 0.996276778834563 -0.0235754003831416 0.964736421318892 0.995662560618248 -0.0292105720346608 0.699510408076808 0.961100601384891 -0.28768425998235 "RB1 MUT" "FH535_IC_50" 0.193292816055692 0.668382680609485 0.270326640929847 0.964736470135593 0.995662560618248 -0.00808593311605557 0.750695234651749 0.968780465757047 -0.0717912971137475 "EZH2 MUT" "ATRA_IC_50" 0.712572021152637 0.919646314953749 -0.285553733205376 0.96477699952127 0.995662560618248 0.0268274969022 0.807909777378813 0.977383317127464 -0.164798741628234 "RUNX1 MUT" "PF.4708671_IC_50" 0.817693487876852 0.955165737441734 0.156897715355807 0.964978738367877 0.995662560618248 -0.0294154016495196 0.868912227661209 0.98751437004641 0.112907060677551 "APC MUT" "Vinblastine_IC_50" 6.99672411179016e-05 0.00725859663615262 1.30519569426091 0.965070499300395 0.995662560618248 0.0110231997729147 0.617604889785285 0.950268369054593 0.190394247333248 "SMARCA4 MUT" "PD.173074_IC_50" 0.617564145896877 0.886326305706232 0.229677472222223 0.965145181609193 0.995662560618248 -0.0171058261269231 0.228238084094705 0.868086691582474 0.581454264784613 "AKT2 MUT" "Bexarotene_IC_50" 0.543285035495004 0.862633715268747 -0.371222548120303 0.965254487817208 0.995662560618248 -0.0236705350636703 0.794060082705072 0.975393509832241 -0.15414966878243 "NF2 MUT" "JW.7.52.1_IC_50" 0.277518647932493 0.735493799937367 -0.938806376306625 0.965406852653332 0.995662560618248 -0.0233971785457898 0.548694244084918 0.947060194029534 -0.577213068336646 "KRAS MUT" "KIN001.135_IC_50" 0.914469089425112 0.984411974629711 0.0184889235313423 0.965437849374393 0.995662560618248 -0.00791895090206049 0.93029086491984 0.99422596912377 -0.0154665380190304 "CDK4 MUT" "RDEA119_IC_50" 0.93720006311416 0.988395451865391 0.0619855850066932 0.965555661779956 0.995662560618248 -0.0308019739172095 0.877548797668532 0.987838063957761 0.109532993438949 "PIK3R1 MUT" "AZD8055_IC_50" 0.510958120834065 0.849393770898084 0.332487017535068 0.965768147164394 0.995662560618248 0.0168986518562387 0.699985558610831 0.961100601384891 0.187873802466873 "EGFR MUT" "Lenalidomide_IC_50" 0.866229753753056 0.967914751268356 0.0381232213438731 0.966056886569379 0.995662560618248 0.0084886226427138 0.498285801686095 0.934042323734638 -0.153906069007972 "KDM5C MUT" "Vorinostat_IC_50" 0.581313285056976 0.875991568255491 -0.494497614173233 0.966087947113642 0.995662560618248 0.0292954832717108 0.69706605675688 0.961100601384891 -0.315590059759319 "GNAS MUT" "AS601245_IC_50" 0.737617020792515 0.929497913781745 0.192502252204586 0.966125809969323 0.995662560618248 -0.0195283026525022 0.73221832964323 0.966676227971091 0.19586741142141 "EZH2 MUT" "VX.702_IC_50" 0.765621996446386 0.936968974174869 -0.200732380038389 0.966217288701105 0.995662560618248 0.023215626940356 0.883412052304683 0.988301482344111 -0.0915944120506184 "KDM6A MUT" "PD.0325901_IC_50" 0.571301744614457 0.872389778906173 -0.305217871847306 0.966293506218647 0.995662560618248 0.0216576859742281 0.966341847847061 0.997173634484198 0.0205479626117568 "SMAD4 MUT" "Imatinib_IC_50" 0.835330814539247 0.959122768755193 -0.110575846379647 0.966338437592429 0.995662560618248 -0.0226921482381732 0.469765414734858 0.929276781658587 -0.430157267811695 "NRAS MUT" "TW.37_IC_50" 0.923023654525892 0.98643792569589 -0.0258848876572537 0.966450618220113 0.995662560618248 -0.0105978947527173 0.768053167128105 0.969901216545994 -0.0879032191731248 "KDM5C MUT" "CGP.082996_IC_50" 0.984033435684247 0.996723172778267 0.0164794178082192 0.966508147324888 0.995662560618248 0.0291349073150868 0.968365969338767 0.997173634484198 -0.0321700688868524 "SMO MUT" "Thapsigargin_IC_50" 0.542110349261871 0.86219233735578 -1.2424166852174 0.966609844974215 0.995662560618248 -0.0648048140600999 0.420671841630385 0.922428741067589 -1.58760459784974 "EZH2 MUT" "AKT.inhibitor.VIII_IC_50" 0.879639501451488 0.972384118670381 0.0922079709316794 0.966658323153302 0.995662560618248 0.0217423508041139 0.877980421704205 0.987889970547261 -0.0983703883810953 "PTEN MUT" "Camptothecin_IC_50" 0.184034841415638 0.660385845878234 -0.371766464757707 0.966737784057105 0.995662560618248 0.00757355802001434 0.366976328101478 0.913948248824328 -0.242196214957631 "BRCA2 MUT" "Pazopanib_IC_50" 0.404861502240145 0.807904911469051 0.643916788674844 0.967035064008567 0.995853247154463 0.0273342543177904 0.846697555192751 0.98378870157398 0.137881004740617 "FGFR2 MUT" "Midostaurin_IC_50" 0.0194913947891947 0.252787916799651 2.18482829757784 0.967323585768308 0.995902935316347 -0.0300040645968515 0.475332114415053 0.929844139269115 0.701295268690819 "SMO MUT" "GW.441756_IC_50" 0.816782971881455 0.955165737441734 0.199649185958253 0.967411879978892 0.995902935316347 -0.0342820901110976 0.687378947666815 0.961100601384891 0.342427599426716 "MET MUT" "WH.4.023_IC_50" 0.862107408335331 0.966470069859388 0.437624374149661 0.967488929810822 0.995902935316347 -0.088856587282496 0.373597686170716 0.913948248824328 2.09322606447795 "KDR MUT" "ZM.447439_IC_50" 0.679012194910503 0.908863195629266 -0.382930510763208 0.967598748490652 0.995902935316347 -0.0298762002726948 0.567514603226122 0.949294892873838 -0.50512311984816 "RUNX1 MUT" "ATRA_IC_50" 0.907275911419961 0.981251818741413 -0.116336191841938 0.967644442983807 0.995902935316347 -0.0317980175007308 0.7079514992849 0.962630898212352 -0.325416131496431 "CDK6 MUT" "Rapamycin_IC_50" 0.468507295733445 0.831405016816516 1.26841211784511 0.967756145904749 0.995902935316347 0.0609529669942409 0.517577193206723 0.939635632721979 1.40400461735524 "NF2 MUT" "CCT007093_IC_50" 0.907723092821024 0.981281110884746 0.0262124875124875 0.968023564822788 0.996034082005067 -0.00915296766297013 0.903531348662238 0.988746233284632 -0.02951420905645 "STK11 MUT" "OSI.906_IC_50" 0.605443005423034 0.882603260686518 0.219524405967452 0.968301465197251 0.996034082005067 0.0159969154169315 0.986432814406159 0.998124818853736 0.0077247430716846 "KIT MUT" "CGP.082996_IC_50" 0.463029195960661 0.829412412394578 -0.851320442176873 0.968627869962469 0.996034082005067 -0.0396408863551255 0.983356109853375 0.998011368051263 -0.024144602822675 "CDK6 MUT" "WO2009093972_IC_50" 0.831253598424144 0.958611936552287 -0.117218642523366 0.968671380038363 0.996034082005067 -0.0192860588101242 0.894893571193191 0.988301482344111 -0.0713881392889446 "NF2 MUT" "CI.1040_IC_50" 0.817779273267933 0.955165737441734 -0.0917551655822733 0.968772819310468 0.996034082005067 0.0140840839077819 0.959861393466896 0.99641548698706 -0.0188978809639132 "KIT MUT" "S.Trityl.L.cysteine_IC_50" 0.688352524683931 0.911852590910835 -0.593774527210886 0.968793522886753 0.996034082005067 0.0326543971868735 0.829007326697135 0.981081757090089 -0.32824015486987 "MET MUT" "Nutlin.3a_IC_50" 0.448586853613749 0.827360921900611 0.430836870775352 0.968863496859486 0.996034082005067 -0.0203708510566275 0.712433189690526 0.962630898212352 0.202664004855181 "MAP2K4 MUT" "CI.1040_IC_50" 0.681289339745568 0.909861476478352 0.214453149805449 0.968874219670495 0.996034082005067 -0.0182033707829027 0.192225420016343 0.851001889249827 0.664247930650396 "MSH2 MUT" "PF.562271_IC_50" 0.461140836696832 0.828966839128293 -0.402582462543554 0.969017549720917 0.996034082005067 -0.0173879374630863 0.297442813121788 0.894167310052 -0.563288659783217 "BRCA2 MUT" "JW.7.52.1_IC_50" 0.279625840884816 0.737882141891724 2.06153566101693 0.969069826359123 0.996034082005067 0.0450498202243686 0.128822859351391 0.820169751013594 2.97652734434234 "MYCL1 MUT" "PHA.665752_IC_50" 0.805378015424819 0.952510646223648 0.139239217687075 0.969117273123047 0.996034082005067 0.0220653799912425 0.810578016524915 0.977383317127464 -0.144589403441192 "BRCA1 MUT" "BX.795_IC_50" 0.405550245901182 0.807916494806729 0.66684456097562 0.969288742432757 0.996093614455824 -0.0238782351300783 0.62681524252986 0.952105511848497 0.34220602736251 "MAP2K4 MUT" "CHIR.99021_IC_50" 0.650144063969619 0.898913406720956 -0.182523767743679 0.969483175534314 0.996093614455824 -0.014580087003661 0.107076019368742 0.792785095696032 -0.687153205322546 "CDKN2a(p14) MUT" "Pyrimethamine_IC_50" 0.194098951802431 0.669174220092154 -0.37505473527879 0.969511676990895 0.996093614455824 -0.0100234374119162 0.367415099458986 0.913948248824328 -0.297602642017647 "NRAS MUT" "CGP.082996_IC_50" 0.729486650305931 0.927497629401141 0.128049660606059 0.969890474352069 0.996366013893629 -0.0122503162946599 0.373518454414648 0.913948248824328 0.365874121904457 "TP53 MUT" "Rapamycin_IC_50" 0.258930009560482 0.723189643810247 -0.410049203089437 0.970001188618885 0.996366013893629 0.0122795993620179 0.316120724405232 0.900294798053993 -0.404652640306684 "SOCS1 MUT" "AZD8055_IC_50" 0.184560034846276 0.660385845878234 -1.33336540000001 0.970257135108898 0.996513659870721 -0.0292414426222907 0.227930131283162 0.867658592338519 -1.17048960477999 "CDK4 MUT" "Bosutinib_IC_50" 0.145412621792148 0.619919550890177 0.878883221578719 0.970418120584754 0.996525743126442 -0.0183940781710567 0.565660901132619 0.949294892873838 0.338357732580384 "MYCL1 MUT" "BX.795_IC_50" 0.753934929837216 0.933869109446012 0.205672759183678 0.970569540970205 0.996525743126442 -0.0186142758067179 0.686874809973604 0.961100601384891 0.258953440484461 "TET2 MUT" "AZD.0530_IC_50" 0.876723655301618 0.971594429690931 0.182003336711713 0.97072242164599 0.996525743126442 0.0375427524051048 0.621036067986173 0.950496524771391 0.665700426223368 "PIK3R1 MUT" "Mitomycin.C_IC_50" 0.160089173514294 0.636336191287136 1.10735926164324 0.970898072347872 0.996525743126442 -0.0224788972329809 0.217732452278437 0.860928912580141 0.940823154761335 "KRAS MUT" "Rapamycin_IC_50" 0.817431501512221 0.955165737441734 0.151116963898917 0.970905763717889 0.996525743126442 0.0218405581849897 0.688781542760559 0.961100601384891 0.288965160041196 "SMARCB1 MUT" "AP.24534_IC_50" 0.903410908041746 0.979752384212816 -0.237923113793103 0.971054653459513 0.996525743126442 -0.0638887697291971 0.992775862354308 0.999469155159075 -0.0168955776844105 "GNAS MUT" "JNK.9L_IC_50" 0.454317811496945 0.828966839128293 0.327739835664336 0.971058081040579 0.996525743126442 -0.0124272036536218 0.500613436629441 0.934042323734638 0.294889002923674 "RUNX1 MUT" "GW.441756_IC_50" 0.694494926411534 0.913615900582776 0.27659630101394 0.971183234978871 0.996525743126442 -0.024827585849894 0.774353911931462 0.971696240086308 0.198624372241074 "BRAF MUT" "Mitomycin.C_IC_50" 0.772253531621381 0.940406364230013 0.0909212896900033 0.97139957203763 0.996525743126442 -0.00972738260284879 0.795232010733818 0.975627957210581 -0.0948427526365201 "NF1 MUT" "FTI.277_IC_50" 0.671724967826015 0.907176009620261 0.101488585389609 0.971525152732203 0.996525743126442 -0.00784288885508261 0.659659298250216 0.958313128388245 -0.10830885553449 "PTEN MUT" "AKT.inhibitor.VIII_IC_50" 0.35101304486433 0.784966682190403 -0.173554941344481 0.971717241649766 0.996525743126442 -0.00578622019601941 0.398745099508186 0.916480913435499 -0.167031634476898 "SMARCB1 MUT" "CHIR.99021_IC_50" 0.849385130559406 0.963526482778845 -0.192994603448276 0.971808082312443 0.996525743126442 0.0339293989393112 0.830869356576258 0.981482581683432 -0.212034943359238 "SMO MUT" "AZD6482_IC_50" 0.637537567786261 0.895456450974187 -0.656155425862079 0.97183550795102 0.996525743126442 -0.0413226161780449 0.539965971552689 0.944569766818715 -0.830070485351707 "FGFR2 MUT" "CMK_IC_50" 0.219468837789128 0.692453909775927 1.21549978612059 0.972127781762213 0.996525743126442 0.0324977290176169 0.279052238174766 0.885713545160236 1.3385057246598 "KIT MUT" "AZD8055_IC_50" 0.643036858250992 0.896094514063559 -0.330230948310141 0.972451997164 0.996525743126442 0.0191822057975378 0.612949017809193 0.949930222127033 -0.35178171939096 "EWS_FLI1 MUT" "PF.4708671_IC_50" 0.9205221726411 0.986016435821543 -0.032997639257295 0.97255737646441 0.996525743126442 -0.012490409905386 0.383321030138442 0.915134825237766 0.378783334438054 "CDKN2A MUT" "KU.55933_IC_50" 0.333872435685367 0.773264085106582 -0.107935078949828 0.972606517501138 0.996525743126442 -0.00356381774048219 0.654426372221047 0.958313128388245 -0.0560398335999181 "SMARCA4 MUT" "GW.441756_IC_50" 0.718999127365252 0.92132587844031 -0.139716780346821 0.972837753272415 0.996525743126442 -0.0128819842537283 0.742162272699838 0.96672489654949 0.14451711320762 "BRAF MUT" "A.770041_IC_50" 0.213922962818599 0.688117861819268 -0.718514238612838 0.972938515417905 0.996525743126442 -0.0174127347691322 0.617271245240716 0.950247055931602 -0.354283639071686 "GNAS MUT" "Methotrexate_IC_50" 0.202560328476113 0.674012093366938 1.07372515182186 0.973038153558138 0.996525743126442 0.0216372584824173 0.412799860285197 0.921714070263062 0.547727259712932 "CDKN2A MUT" "SB.216763_IC_50" 0.625165736835482 0.890724841246629 -0.0628313422625365 0.973195381171626 0.996525743126442 0.00434566380201841 0.490485651513811 0.933639405738697 -0.0971150357872887 "MDM2 MUT" "ZM.447439_IC_50" 0.20142205402728 0.674012093366938 0.651519978174605 0.973284859005009 0.996525743126442 -0.0135790790330481 0.214608890575665 0.859434499119166 0.594411445137981 "SOCS1 MUT" "Temsirolimus_IC_50" 0.345880048821635 0.78201647494525 -1.52234151992409 0.973361425978088 0.996525743126442 -0.0412664721273548 0.537562719844882 0.943597179771607 -0.944018183606689 "MLLT3 MUT" "MG.132_IC_50" 0.752873689407041 0.933706358835908 -0.23944503472222 0.973389001883742 0.996525743126442 -0.022229712274658 0.647327893829541 0.957449344088104 -0.341690105946764 "MSH2 MUT" "Doxorubicin_IC_50" 0.149725341697339 0.62466549367193 -1.06725020827069 0.973541526004019 0.996525743126442 -0.015434918785544 0.249393074770658 0.875707386589409 -0.820376675390174 "BRCA2 MUT" "Bicalutamide_IC_50" 0.64255985018348 0.896094514063559 0.118144623467602 0.97368828139681 0.996525743126442 0.00803521936726551 0.374368723846828 0.913948248824328 0.213921701595316 "JAK2 MUT" "Nilotinib_IC_50" 0.460651941133471 0.828966839128293 0.459820298576901 0.973767288710047 0.996525743126442 -0.016611608441698 0.754614135889462 0.969719019076012 0.190803289119772 "NF1 MUT" "AMG.706_IC_50" 0.57203766003135 0.872389778906173 0.157879351441244 0.973818085529172 0.996525743126442 -0.00852270735228359 0.0946947039265954 0.770131561879207 0.46719222829236 "NF2 MUT" "CHIR.99021_IC_50" 0.371980870198199 0.791651595550014 -0.284608434937611 0.973859489418308 0.996525743126442 -0.00997949427792445 0.502596445328182 0.934042323734638 0.222280923343075 "KRAS MUT" "PF.562271_IC_50" 0.369485082327002 0.789535578103719 -0.164047552243902 0.973886978832772 0.996525743126442 0.00516517907518126 0.681950091171698 0.961100601384891 -0.0842650846631316 "FGFR3 MUT" "A.770041_IC_50" 0.290049268626702 0.745349408181059 -1.91779704067797 0.97393402263629 0.996525743126442 0.0480358125523096 0.357485838953185 0.91161229252998 -1.58755307216853 "BRCA1 MUT" "JNK.Inhibitor.VIII_IC_50" 0.844130535836848 0.960498931426639 0.112744005736138 0.974021892169795 0.996525743126442 0.0179119800379899 0.807037314899954 0.977383317127464 0.140542743786803 "KDR MUT" "Docetaxel_IC_50" 0.552931815393948 0.866603215811789 -0.620896618955513 0.97409442341055 0.996525743126442 0.0255010889602151 0.74080556820078 0.96672489654949 -0.337225269194589 "FBXW7 MUT" "AICAR_IC_50" 0.485699837508854 0.840221318124096 -0.260433775379553 0.974170083389262 0.996525743126442 -0.0108503574683027 0.827809520060907 0.981081757090089 -0.0824744573602158 "FGFR3 MUT" "AG.014699_IC_50" 0.834778860529333 0.959122768755193 -0.212556387892373 0.974196205587633 0.996525743126442 -0.029026407834416 0.739660966664313 0.96672489654949 -0.312791417817403 "FGFR3 MUT" "SB.216763_IC_50" 0.965684327180766 0.994434372972651 0.0443573294346968 0.974842465060438 0.997029436382988 0.0314017863227321 0.957945193297388 0.99641548698706 -0.0523170880250488 "MLLT3 MUT" "Nilotinib_IC_50" 0.82062661945495 0.956052080201943 0.0867991338493289 0.974913143289029 0.997029436382988 -0.00974251512479044 0.948382200180051 0.995668765770473 0.0233608634417107 "MAP2K4 MUT" "Vinorelbine_IC_50" 0.92782742341576 0.986593180452362 0.0514459949979722 0.975161883005389 0.997168990555078 -0.0129969331236052 0.887937920404216 0.988301482344111 -0.0864544158476065 "MYCL1 MUT" "Lapatinib_IC_50" 0.645656400033174 0.897070476954727 0.337807214452211 0.975282978220185 0.997178002483705 0.019900515690165 0.951441023760422 0.995669074626174 -0.0409014321313389 "PDGFRA MUT" "BMS.708163_IC_50" 0.890170618553408 0.975801867105169 0.07537735505618 0.975426612198882 0.997210054442071 -0.0169808376876517 0.77100114838168 0.969901216545994 -0.163116951532026 "APC MUT" "X17.AAG_IC_50" 0.334996246590504 0.773264085106582 0.391587352822584 0.976105277883994 0.997744192622786 0.0112073421751091 0.489041640059496 0.933639405738697 0.303176332950403 "FAM123B MUT" "Gefitinib_IC_50" 0.553810199185444 0.866925654369292 0.482410978095244 0.976173774315886 0.997744192622786 -0.0219431996702453 0.85405329243019 0.984631915507353 0.137146243159572 "FGFR3 MUT" "GDC.0449_IC_50" 0.917478332008351 0.984975746996111 -0.0896971621621619 0.976353718019231 0.99779317427165 -0.0228452527688922 0.757721404137377 0.969901216545994 -0.263865722650812 "CTNNB1 MUT" "JNK.9L_IC_50" 0.309746147023611 0.757046299071613 -0.364797599647263 0.97677769101468 0.99779317427165 -0.00816382953444048 0.518077008889432 0.939635632721979 -0.258644586711724 "FBXW7 MUT" "Bosutinib_IC_50" 0.46666270528103 0.830828665219814 -0.278875819271913 0.976971329507472 0.99779317427165 0.00911871636757338 0.960581626244723 0.9966034372289 0.0185685225764628 "KDM5C MUT" "ABT.263_IC_50" 0.797310995162324 0.949524851900765 -0.323532039791262 0.977014178567757 0.99779317427165 -0.0326855447722145 0.85425719624546 0.984631915507353 -0.199442127615177 "SMO MUT" "JNJ.26854165_IC_50" 0.988188616453242 0.997992312673585 -0.011951748878925 0.977078813319021 0.99779317427165 -0.0215556129342469 0.625230258930147 0.950863149839883 -0.371521332792412 "JAK2 MUT" "ABT.263_IC_50" 0.818252553817894 0.955165737441734 0.20529437860892 0.97723081594716 0.99779317427165 0.022939374923024 0.811547529011107 0.977383317127464 0.203990961160315 "KDR MUT" "NU.7441_IC_50" 0.833248528903394 0.958775297273765 0.174422083003955 0.977278083960734 0.99779317427165 0.0207114748141316 0.584362889208156 0.949294892873838 0.441090762510097 "MYCL1 MUT" "ABT.888_IC_50" 0.923608338892049 0.98643792569589 -0.0361183025048166 0.97730857509296 0.99779317427165 -0.0090249040489241 0.619124315464286 0.950394619652337 -0.19189535091853 "RB1 MUT" "DMOG_IC_50" 0.774117306796144 0.94153218611416 0.0658670565302151 0.977333322283835 0.99779317427165 0.0060241851030467 0.293770554714909 0.894167310052 -0.259203542421714 "KDM6A MUT" "BMS.708163_IC_50" 0.930496269406199 0.986689293492114 0.0297959864460489 0.977363054862047 0.99779317427165 0.00977970990793353 0.848656772700538 0.984060686558751 0.0661067865032982 "MYCL1 MUT" "AICAR_IC_50" 0.945352060226505 0.990147156460271 0.0447344866071433 0.977512636939329 0.99779317427165 -0.0163842325056487 0.630204133882546 0.952523560833852 0.331918399904319 "EP300 MUT" "TW.37_IC_50" 0.63293777544959 0.89399270048764 -0.37328740524345 0.97778876125381 0.99779317427165 0.0197584469562838 0.562255185930832 0.949294892873838 -0.43083669684542 "SMO MUT" "GDC.0449_IC_50" 0.975437715098248 0.996276778834563 -0.0266546911196914 0.978050445875279 0.99779317427165 -0.0211165279155862 0.733394493988631 0.96672489654949 -0.291043853499337 "PDGFRA MUT" "Mitomycin.C_IC_50" 0.956841398684992 0.99327782426188 -0.0538657220279736 0.978248494904523 0.99779317427165 0.0212366000300442 0.487876725735439 0.933639405738697 -0.682158367587661 "NF2 MUT" "NU.7441_IC_50" 0.734133465769155 0.928593402067957 0.105907498413291 0.978287802098578 0.99779317427165 -0.00751896598661511 0.39982820886378 0.916480913435499 0.269825981322568 "FBXW7 MUT" "Vinorelbine_IC_50" 0.462609822994395 0.82931728663973 -0.323201827110386 0.978288741634516 0.99779317427165 -0.008870951083118 0.353657349169277 0.911252930312559 -0.416886692155729 "CDKN2C MUT" "Cyclopamine_IC_50" 0.971249054060994 0.995220468612913 0.0219781249999994 0.978377123927618 0.99779317427165 0.0152155011973902 0.780014076167796 0.972337708041191 0.207337982384001 "IDH1 MUT" "PD.0325901_IC_50" 0.610856769643659 0.884818029552257 -0.809885102970305 0.978486841859204 0.99779317427165 0.0401829027683273 0.373579032556235 0.913948248824328 -1.24714977089949 "FGFR2 MUT" "AUY922_IC_50" 0.000381766296215646 0.0251145664940085 3.35660053315885 0.978527962437238 0.99779317427165 0.0175123988417585 0.0129425807113646 0.477665075882967 2.59298353975359 "MAP2K4 MUT" "Vinblastine_IC_50" 0.239365765567858 0.711026565113714 0.613383558027086 0.978562712696791 0.99779317427165 0.0101499043478564 0.594398911083617 0.949294892873838 -0.288535480205899 "NF1 MUT" "AKT.inhibitor.VIII_IC_50" 0.201290947689434 0.674012093366938 0.444461514448047 0.978591826002436 0.99779317427165 0.0080484078143942 0.917741099357893 0.992963223576061 0.0379963958763706 "MLLT3 MUT" "Bicalutamide_IC_50" 0.861466584484828 0.966384100200122 -0.0240645101062009 0.979011227613082 0.99779317427165 -0.00343321377955983 0.952742510185172 0.99568364368633 0.00800048814861121 "JAK2 MUT" "Methotrexate_IC_50" 0.687628124715323 0.911748124009352 0.339040091093115 0.979055487016525 0.99779317427165 -0.0168075762346581 0.54507698579255 0.946853280734584 0.440563584615667 "ERBB2 MUT" "AZD7762_IC_50" 0.0028814310078716 0.0841775946740383 1.30770095490196 0.979056534912204 0.99779317427165 0.00936287833963707 0.116570125278315 0.802933994982728 0.67062308301897 "MAP2K4 MUT" "Sunitinib_IC_50" 0.955737260236651 0.992751183257459 0.0759317758816828 0.979167191747652 0.99779317427165 0.0263048108768019 0.918161899851928 0.992963223576061 0.149694552140231 "MET MUT" "Doxorubicin_IC_50" 0.777287784044141 0.941790749776385 -0.167909564086092 0.97917701042271 0.99779317427165 -0.00967525485294723 0.545157268332749 0.946853280734584 -0.342567173185783 "SMAD4 MUT" "MK.2206_IC_50" 0.028930696144229 0.316210068663154 0.814486017638584 0.979291004974254 0.99779317427165 -0.0079756418945919 0.20560807667267 0.853446327418758 0.493012170898307 "MLH1 MUT" "Tipifarnib_IC_50" 0.468058841198404 0.831367686108334 -0.473798272566375 0.979608891046566 0.99779317427165 -0.0112386579188779 0.835145619975935 0.981626636221501 -0.134645474949449 "JAK2 MUT" "QS11_IC_50" 0.310304748606043 0.757046299071613 0.756326233333347 0.979649546192937 0.99779317427165 0.0139844650714293 0.295112610655405 0.894167310052 0.828381471797403 "CDKN2A MUT" "ABT.888_IC_50" 0.67717881428176 0.908720747099578 -0.038484205321649 0.979659218489579 0.99779317427165 -0.00207332114938595 0.450593750751058 0.925809648901546 -0.074123609267829 "TSC1 MUT" "DMOG_IC_50" 0.969122213735657 0.994856543446662 -0.0490772413793107 0.979999389761732 0.99779317427165 0.0285947863803271 0.847874584501572 0.98378870157398 0.228826680975059 "BRAF MUT" "BMS.708163_IC_50" 0.722682987330986 0.923705342742609 -0.0629891369706759 0.980033138178927 0.99779317427165 0.00495014603481001 0.519425259071697 0.939635632721979 0.136293054802946 "MSH2 MUT" "AKT.inhibitor.VIII_IC_50" 0.355169374484253 0.785252181551816 -0.526928346689896 0.980200085701224 0.99779317427165 0.0122025129887212 0.3120941366611 0.898155550125478 -0.567363157009489 "TET2 MUT" "GNF.2_IC_50" 0.788192892010823 0.946449577332088 0.195452879408417 0.980590782222785 0.99779317427165 -0.0170501162823971 0.895301828282123 0.988301482344111 -0.118741606323099 "MSH2 MUT" "Imatinib_IC_50" 0.722578264314268 0.923705342742609 -0.203618339021616 0.98061508874653 0.99779317427165 -0.0138317032190361 0.981908292399414 0.997977517143419 -0.0140184585570966 "PIK3R1 MUT" "Dasatinib_IC_50" 0.340807614845223 0.778503205456979 1.67861467353953 0.980650624944049 0.99779317427165 0.0351731946267688 0.293449028105968 0.894167310052 1.59642096864041 "KDM5C MUT" "Vinblastine_IC_50" 0.380064950954199 0.797344611908192 -1.1105528121442 0.980733936706893 0.99779317427165 -0.0222215838766304 0.311977537558955 0.898149383211927 -1.190881077741 "NRAS MUT" "GDC.0449_IC_50" 0.969742086284344 0.995036245554468 -0.00811249189985262 0.980830539743223 0.99779317427165 -0.00475243710487096 0.952433614700296 0.99568364368633 -0.0144328546947787 "PIK3R1 MUT" "Axitinib_IC_50" 0.67008929706061 0.906882709825482 0.269890800383874 0.980836539963999 0.99779317427165 0.0128368027542684 0.713006609699336 0.962630898212352 0.203954327950811 "TET2 MUT" "PF.562271_IC_50" 0.993650655385828 0.998970779334534 -0.00706970811744399 0.980945472206881 0.99779317427165 0.0174979644120214 0.245448644138053 0.875707386589409 -1.24079351344872 "BRCA2 MUT" "XMD8.85_IC_50" 0.260746442386645 0.724105426777921 1.45125523972605 0.980974192975458 0.99779317427165 0.0267983205146315 0.252247443749697 0.875707386589409 1.47365993247433 "NOTCH1 MUT" "AZD6244_IC_50" 0.607507998900967 0.884017916530788 -0.31202434823316 0.981018364024309 0.99779317427165 0.0137415315564774 0.740112792036066 0.96672489654949 -0.196074564847458 "FBXW7 MUT" "CGP.60474_IC_50" 0.178764958804097 0.658486768618493 -0.845315018195891 0.981060286294375 0.99779317427165 0.0113111353909798 0.201239027089058 0.851001889249827 -0.803578243189782 "RUNX1 MUT" "AZD8055_IC_50" 0.9157016460345 0.98476490303336 -0.0870121071428555 0.981178077787827 0.99779317427165 0.0150144931542648 0.757598827627636 0.969901216545994 -0.243372691676594 "CDK6 MUT" "Embelin_IC_50" 0.742140547750775 0.929570057037101 0.167697587873463 0.981393982493314 0.99779317427165 -0.00949278171594165 0.866230680117104 0.987077901072027 0.0908232191801848 "HRAS MUT" "RDEA119_IC_50" 0.663294005925144 0.903526384925934 -0.457657247011956 0.981478245621647 0.99779317427165 -0.0221333194592072 0.64974545689191 0.957867556929346 0.407426843534532 "TET2 MUT" "S.Trityl.L.cysteine_IC_50" 0.384913119836785 0.798746759187088 -1.05150585779294 0.981604931619771 0.99779317427165 0.0154145658113486 0.479247239991654 0.930304161706959 -1.06323819730059 "MSH6 MUT" "AZD.2281_IC_50" 0.286386911027233 0.741305709900881 -0.717045534653477 0.981675869245848 0.99779317427165 0.0117007727023948 0.758724724669323 0.969901216545994 -0.181376605204772 "VHL MUT" "Docetaxel_IC_50" 0.966110775445263 0.994434372972651 -0.0273617226562519 0.981726917777916 0.99779317427165 -0.0111421070271695 0.640389611482657 0.955094994589269 0.314282308575976 "PIK3R1 MUT" "Imatinib_IC_50" 0.667735615609023 0.905919726780999 0.269226428571431 0.981842799714626 0.997796762131319 -0.01404832283611 0.579278886209631 0.949294892873838 0.364085792891805 "SMARCA4 MUT" "Thapsigargin_IC_50" 0.714906945297683 0.920308547391321 0.319972508191457 0.982141295134516 0.997985908705908 0.0148893709624364 0.347709279453295 0.909999728614578 0.89797118541741 "PDGFRA MUT" "RDEA119_IC_50" 0.713561014393227 0.91988693852899 0.385879657370517 0.982486441276528 0.998222409904685 0.0209047135073928 0.442044215169971 0.924472815010418 0.702508822993787 "JAK2 MUT" "VX.680_IC_50" 0.69687015698199 0.914682004129471 0.594264399317401 0.982787936420898 0.998336474768363 0.0212335931615807 0.343371063141704 0.907180409180092 1.84132013194363 "KIT MUT" "CCT007093_IC_50" 0.941469824452968 0.989446598697723 -0.0373126681614352 0.982823533261998 0.998336474768363 0.0110334753112242 0.912973599589499 0.99082410867764 -0.0566435537080248 "NOTCH1 MUT" "BMS.708163_IC_50" 0.804493688457621 0.952500792853237 -0.150896473094174 0.983158976693471 0.998413818290433 0.012924354926299 0.75497070431488 0.969873373096723 -0.19082707741528 "BRCA2 MUT" "Shikonin_IC_50" 0.771919652958116 0.940249942799371 0.243323288194445 0.983255847181657 0.998413818290433 -0.0149033032402225 0.751828051205872 0.968780465757047 -0.261496226715156 "NF1 MUT" "Vorinostat_IC_50" 0.630151874635369 0.892706779173187 0.135815917031842 0.983339228509703 0.998413818290433 -0.00452564279653202 0.79992397542195 0.976360691959787 0.0693220922282876 "MLLT3 MUT" "BIBW2992_IC_50" 0.738635352881521 0.929570057037101 -0.147850813725489 0.983349360273215 0.998413818290433 0.00885906379456946 0.303601637887985 0.894622967627816 -0.441062616525734 "MS-HL MUT" "FH535_IC_50" 0.717842259821437 0.92132587844031 -0.0737033314218875 0.983528232963712 0.99848127994407 -0.00363679369658528 0.270824674643853 0.879734431423575 -0.239387908779628 "KDM6A MUT" "RO.3306_IC_50" 0.629474066555365 0.892582202029064 -0.17013423611111 0.983684307680356 0.998525584239255 0.00694840306633163 0.57413449277547 0.949294892873838 -0.204246721078763 "KIT MUT" "SL.0101.1_IC_50" 0.58887958117755 0.876506729771444 0.330092148362238 0.983992220484782 0.998637047962555 -0.0106880044859763 0.886657118252091 0.988301482344111 0.0843154320485938 "EGFR MUT" "Vinblastine_IC_50" 0.343432969592248 0.779915522083427 0.360699324110672 0.984256563753443 0.998637047962555 0.00546515041994217 0.737361334889766 0.96672489654949 0.125587237703189 "FBXW7 MUT" "CGP.082996_IC_50" 0.21075698017752 0.684613292229902 -0.692066391792485 0.984580286728306 0.998637047962555 -0.00914134311646456 0.36073787076356 0.91161229252998 -0.513489333857905 "CCND3 MUT" "CEP.701_IC_50" 0.633596430354652 0.89399270048764 0.62350845920303 0.984615283920287 0.998637047962555 0.0184771302665539 0.728858338487597 0.965407830614903 0.409211387732376 "FLCN MUT" "PD.0325901_IC_50" 0.805184292839998 0.952510646223648 0.27815800049702 0.984653168083277 0.998637047962555 -0.0203897698128752 0.815895512592956 0.977383317127464 -0.323907511137108 "KDM5C MUT" "JNJ.26854165_IC_50" 0.532460424450296 0.858062244518794 -0.411873138576785 0.984695897301325 0.998637047962555 -0.0118561980035753 0.386227682485017 0.91566150942174 -0.538858166445341 "MAP2K4 MUT" "AZ628_IC_50" 0.0720569001239639 0.474889173046706 -2.43664598972605 0.984723049172467 0.998637047962555 -0.01946765304776 0.648131631538356 0.957493413330814 0.624030488944861 "FAM123B MUT" "WO2009093972_IC_50" 0.621357145324006 0.888247588669681 0.382414296296293 0.985013058079682 0.998637047962555 -0.0130652800028622 0.779331654047123 0.972337708041191 -0.217411509289454 "CCND2 MUT" "AG.014699_IC_50" 0.99123728439493 0.99820595563118 0.0111924910313895 0.985400882386853 0.998637047962555 0.0162989793339947 0.492411363461031 0.933639405738697 -0.64814930178777 "CCND3 MUT" "NSC.87877_IC_50" 0.93059976583221 0.986689293492114 -0.0489153114186858 0.985546969985144 0.998637047962555 -0.0100169768870796 0.82110255075914 0.977383317127464 0.128984276977757 "BCR_ABL MUT" "JNK.9L_IC_50" 0.787068374161703 0.946449577332088 0.186140885813147 0.985609194411218 0.998637047962555 -0.0116601820454941 0.232750016722237 0.869962136993019 0.830803665528898 "IDH1 MUT" "Vinblastine_IC_50" 0.335916528557801 0.773470233373563 -1.21735660721062 0.98577298190566 0.998637047962555 -0.0162588285341902 0.421773933733146 0.922428741067589 -0.960015228184281 "TET2 MUT" "CHIR.99021_IC_50" 0.583595496301943 0.876506729771444 0.45518157167529 0.985836149347209 0.998637047962555 -0.0141383204671812 0.972892556450964 0.99742775226181 0.0333793220661157 "MS-HL MUT" "Gefitinib_IC_50" 0.463248375848407 0.829490249358073 -0.159832134307513 0.98589419926592 0.998637047962555 0.00348788178641761 0.985613470599731 0.998124818853736 0.00387128533112998 "MSH6 MUT" "VX.680_IC_50" 0.517806988017103 0.852353345422823 -0.855686886986312 0.985900210242408 0.998637047962555 0.0152534424590678 0.443806014739423 0.925809648901546 -1.0393966309919 "MYCL1 MUT" "AP.24534_IC_50" 0.60380747805773 0.881685993526915 0.458118951048947 0.985915275638034 0.998637047962555 -0.0140263815175936 0.2167262211165 0.860576337437605 -1.11925179570379 "IDH1 MUT" "ABT.263_IC_50" 0.872864646202466 0.970487466477047 0.246649337890621 0.985993959916134 0.998637047962555 -0.0242055827882802 0.989499275027571 0.998596878102629 0.0177123184496108 "ALK MUT" "Pyrimethamine_IC_50" 0.90939174084371 0.981529929795606 -0.153539761904762 0.986123549494712 0.998637047962555 0.0198672246646571 0.771193920978918 0.969901216545994 -0.483148897529853 "KRAS MUT" "MG.132_IC_50" 0.301672835048493 0.751727398447156 -0.540520284914358 0.986230755748561 0.998637047962555 -0.00860227608467177 0.442003244985527 0.924472815010418 -0.409677761590602 "KIT MUT" "Cisplatin_IC_50" 0.401113801654222 0.806415132522709 -0.698557003809528 0.986411850091894 0.998637047962555 -0.0123428413241851 0.399875061262922 0.916480913435499 -0.676204551008643 "SMO MUT" "AP.24534_IC_50" 0.865967449254748 0.967800561563183 -0.33090965517242 0.986708507047296 0.998637047962555 0.0292736607436895 0.470329244237962 0.929276781658587 -1.3251048148378 "BRAF MUT" "PHA.665752_IC_50" 0.801520585539832 0.9507092914502 -0.077947101894521 0.986810338701764 0.998637047962555 0.00555313950058383 0.395183593654423 0.916003810456352 0.348558572966388 "KDM5C MUT" "CMK_IC_50" 0.763349555014561 0.936244886169491 -0.258859232876713 0.986923824542769 0.998637047962555 -0.0128935431380018 0.954221337266547 0.99568364368633 -0.0503523199070377 "MS-HL MUT" "Bosutinib_IC_50" 0.438128092658257 0.824038297893374 -0.187053066057744 0.987019343248847 0.998637047962555 0.00323600372315371 0.983795785449402 0.998068353961177 0.00495877413074331 "SMAD4 MUT" "PHA.665752_IC_50" 0.503494935350053 0.846767322410355 -0.350497654802535 0.987078008629727 0.998637047962555 0.00865120855430746 0.71424945552095 0.962630898212352 -0.20794598703688 "KDM6A MUT" "OSI.906_IC_50" 0.744753841707954 0.9301306241328 -0.147511608084962 0.987450258845914 0.998637047962555 0.00674740447771576 0.874329860812561 0.98777404048288 -0.0762402966339401 "NF2 MUT" "AUY922_IC_50" 0.241993916470003 0.711340033600749 -0.492215552158278 0.987451189899641 0.998637047962555 0.00449296301546661 0.727683242609471 0.965402608571648 0.150980958108178 "KDM5C MUT" "Parthenolide_IC_50" 0.761318653273683 0.93574319967042 0.28099925675676 0.987496190798593 0.998637047962555 0.0135692856125446 0.856178560672929 0.984631915507353 0.171180909371421 "PTEN MUT" "Dasatinib_IC_50" 0.63815657749625 0.895624997957207 -0.289899266801075 0.987587492962712 0.998637047962555 0.00803989738682393 0.499415150837047 0.934042323734638 0.391327255983118 "MSH6 MUT" "WZ.1.84_IC_50" 0.990956695405332 0.998036562927507 0.00956034246575316 0.987636075373648 0.998637047962555 -0.0108767035375025 0.684689793130958 0.961100601384891 -0.323375852638954 "CCND1 MUT" "Mitomycin.C_IC_50" 0.432764370983844 0.82228934075899 0.342573386127945 0.987772855144663 0.998637047962555 -0.00527354349798432 0.945563652053851 0.995668765770473 0.0310952592145045 "VHL MUT" "BAY.61.3606_IC_50" 0.817459321829701 0.955165737441734 -0.157087486379612 0.987797508783049 0.998637047962555 -0.00724203436343465 0.390955038114274 0.915926348152589 -0.59406159830546 "MSH6 MUT" "Etoposide_IC_50" 0.423444739341633 0.81802451626078 -0.69777444512195 0.987924575183494 0.998637047962555 0.00859514719322177 0.517358536527104 0.939635632721979 -0.531299728024005 "MLLT3 MUT" "MK.2206_IC_50" 0.84783252429738 0.962618339080162 -0.0898515932203382 0.988029479807221 0.998637047962555 -0.00560348157754919 0.456842904293427 0.925841766232465 -0.361954487587526 "MYCN MUT" "GDC0941_IC_50" 0.985936270568318 0.996887811168928 -0.00714140934065939 0.98818352292711 0.998637047962555 0.00501129511498574 0.595760802602224 0.949294892873838 -0.264836903957031 "EZH2 MUT" "Camptothecin_IC_50" 0.936958939822551 0.988375382416448 -0.0798613874045824 0.988483924319361 0.998637047962555 0.00916519806068278 0.669445375208718 0.959230524020512 -0.379390730610053 "PIK3CA MUT" "AP.24534_IC_50" 0.587627599035989 0.876506729771444 0.214421246212123 0.988564029894723 0.998637047962555 0.00518844662390216 0.767482847473427 0.969901216545994 0.120674566667615 "MET MUT" "FH535_IC_50" 0.494995700445408 0.843282996121548 -0.330205284773532 0.988573080288228 0.998637047962555 -0.00596049953393624 0.87199846400836 0.987643979884169 -0.0748141745568962 "PTEN MUT" "Bicalutamide_IC_50" 0.909225677567259 0.981529929795606 -0.00830776422764211 0.988793594214117 0.998637047962555 -0.000995745183002656 0.917567924307902 0.992963223576061 0.00765228004398294 "NRAS MUT" "Lenalidomide_IC_50" 0.569251191191997 0.872389778906173 -0.101717601029049 0.988909950159659 0.998637047962555 -0.00227102094721138 0.949566612276572 0.995668765770473 -0.0123254283251298 "FLCN MUT" "Nilotinib_IC_50" 0.417872112308904 0.814099702076568 0.665985815238098 0.989126708472071 0.998637047962555 -0.00905860412041802 0.876994827676274 0.987838063957761 0.161389342381498 "SMARCA4 MUT" "BMS.754807_IC_50" 0.958331689836239 0.993340772343095 0.0366168459685198 0.989313369312706 0.998637047962555 -0.00780558274656707 0.465358967588707 0.929276781658587 0.563820115916721 "MSH6 MUT" "BI.2536_IC_50" 0.550534132831985 0.865580796066258 -0.681380692832759 0.989314131579911 0.998637047962555 -0.00907852260416312 0.466284246977981 0.929276781658587 -0.856197079442517 "MAP2K4 MUT" "Salubrinal_IC_50" 0.777577390466386 0.941852810247132 0.244581099656357 0.989498810262728 0.998637047962555 -0.00945112249432883 0.932506612533991 0.994235539701634 -0.0849489647967322 "SETD2 MUT" "Doxorubicin_IC_50" 0.167544225080015 0.647446641789 1.9047782904348 0.989528883543863 0.998637047962555 -0.0114212243046172 0.162887566231688 0.839927262232576 1.83459006209708 "NF2 MUT" "Axitinib_IC_50" 0.774197349075211 0.94153218611416 -0.113608065991751 0.98954077680332 0.998637047962555 -0.00441447244852022 0.569889978573951 0.949294892873838 -0.211245414476972 "CDH1 MUT" "IPA.3_IC_50" 0.384255496842439 0.798569876743396 0.603206196009395 0.98957665558277 0.998637047962555 -0.00772165013274289 0.935918494401307 0.994729228933513 0.0554870907102106 "EP300 MUT" "Bortezomib_IC_50" 0.358211146227013 0.786601117838604 -1.46676767006803 0.989789882392879 0.998637047962555 0.0166350184893599 0.770424807507497 0.969901216545994 -0.443616183072322 "CDK6 MUT" "AP.24534_IC_50" 0.579285387061372 0.874194311383525 0.515472041884816 0.989802234585446 0.998637047962555 -0.0107260275345361 0.373579860020491 0.913948248824328 0.823025451557478 "CDH1 MUT" "NU.7441_IC_50" 0.605868218770075 0.882603260686518 0.303134010603051 0.989869673446753 0.998637047962555 -0.00657748958881539 0.988965498887505 0.998559633198815 0.0085935821260364 "GNAS MUT" "GDC.0449_IC_50" 0.376580665435755 0.795051761241315 0.384830800781249 0.989992111399467 0.998637047962555 -0.00485628679659114 0.548032543606146 0.947060194029534 0.258849828776163 "MSH2 MUT" "CCT018159_IC_50" 0.496228635231791 0.843896642253943 -0.483341055045868 0.990008123015001 0.998637047962555 0.00833169935888456 0.379089431602567 0.915134825237766 -0.630671735780029 "PIK3CA MUT" "BMS.536924_IC_50" 0.831571790782784 0.958611936552287 0.149104760292524 0.990141653291607 0.998637047962555 0.00640756698060443 0.975712596899822 0.99742775226181 0.0221906802884589 "TP53 MUT" "OSI.906_IC_50" 0.993605966655214 0.998970779334534 -0.00143762844677183 0.99033311522929 0.998637047962555 0.00213042726903553 0.860478245123799 0.985524480087535 -0.0341893187363955 "SMO MUT" "Camptothecin_IC_50" 0.750457177102512 0.932697982453688 0.506277538899429 0.990396637704284 0.998637047962555 0.0120563800215376 0.747297904493943 0.968780465757047 -0.450767979251583 "CDKN2a(p14) MUT" "Shikonin_IC_50" 0.0419703212081294 0.368354819675836 -0.358839197147143 0.990434427078936 0.998637047962555 -0.00186906515955383 0.654302316857727 0.958313128388245 -0.0863250986948369 "MAP2K4 MUT" "VX.702_IC_50" 0.458942830683339 0.828966839128293 0.324010940337226 0.990471863538541 0.998637047962555 -0.00426598070410442 0.64045602088261 0.955094994589269 0.210380186793177 "APC MUT" "Sorafenib_IC_50" 0.945549527670041 0.990147156460271 -0.0388260804195798 0.990480857089404 0.998637047962555 0.00665487116027748 0.850733243319088 0.984453468864253 0.133770214044504 "VHL MUT" "Gefitinib_IC_50" 0.952414741876708 0.992561499112566 0.03451903502879 0.990566294240233 0.998637047962555 -0.00619952965338516 0.612590036170894 0.949930222127033 -0.286141886558482 "NF1 MUT" "ABT.888_IC_50" 0.223234929208547 0.696139064632428 0.280259151395137 0.990950667826466 0.998637047962555 0.00221369348026195 0.686102107626013 0.961100601384891 0.0924810853241438 "CDK6 MUT" "JW.7.52.1_IC_50" 0.489919811283562 0.84263880174142 1.07738595238095 0.990974319376258 0.998637047962555 -0.0107390453705822 0.322257582744123 0.900918773778407 1.91767289064789 "BRAF MUT" "BX.795_IC_50" 0.94183862639398 0.989446598697723 0.0168022440087146 0.991032644124597 0.998637047962555 0.00214900875784978 0.856041817494263 0.984631915507353 -0.0443118203367908 "MYC MUT" "Cisplatin_IC_50" 0.730077245122168 0.927584551349067 0.0930225856157523 0.991264276576494 0.998637047962555 -0.00256775916129705 0.676413465961247 0.960256725054738 0.112748675189561 "BRCA2 MUT" "Nilotinib_IC_50" 0.25919583952126 0.723189643810247 0.830176666030546 0.991372156660055 0.998637047962555 -0.00649504259039266 0.589906267924092 0.949294892873838 0.360275847247207 "CDH1 MUT" "GDC0941_IC_50" 0.976450618465711 0.996276778834563 -0.0220235217391307 0.991374476249088 0.998637047962555 0.00652461526498553 0.701527394037376 0.961163959649172 -0.311706243333919 "MET MUT" "AKT.inhibitor.VIII_IC_50" 0.511052663587583 0.849393770898084 -0.320299664543861 0.991580565725535 0.998637047962555 -0.0044344018664252 0.633164907412806 0.952523560833852 -0.22699777676209 "CDK6 MUT" "BMS.536924_IC_50" 0.457288334638319 0.828966839128293 1.06570578911564 0.991637128733608 0.998637047962555 0.0111925412450953 0.079296538211659 0.741811190933953 2.91150565364394 "MLLT3 MUT" "Gemcitabine_IC_50" 0.602943661556973 0.880745626033854 -0.468590475505313 0.991683222379732 0.998637047962555 0.00628039707163093 0.830946772599486 0.981482581683432 0.188177305928462 "EGFR MUT" "AMG.706_IC_50" 0.575479164084056 0.872751102498378 0.156468035846268 0.991709516948742 0.998637047962555 0.0026786612149662 0.789080564014892 0.975340917051672 0.0722431603316398 "FBXW7 MUT" "Axitinib_IC_50" 0.837388987229368 0.959212493377535 -0.07781371146245 0.991840953877658 0.998637047962555 -0.00328612011087828 0.998495837864879 0.999689936809094 -0.00066507415427905 "KIT MUT" "JNJ.26854165_IC_50" 0.320426048528306 0.762015213745527 -0.568171351351353 0.991889646217646 0.998637047962555 0.00545194310454759 0.505604101873259 0.93586286551405 -0.363045823890486 "FGFR2 MUT" "BI.D1870_IC_50" 0.601866247961224 0.880745626033854 0.594749750476197 0.991890260114592 0.998637047962555 -0.0100784025434774 0.255672685579054 0.875707386589409 1.73271410369222 "MET MUT" "CHIR.99021_IC_50" 0.922070362097898 0.986140039233073 -0.0427255558032149 0.99214633477078 0.9986393956939 -0.00409363532144718 0.871125560016269 0.987549923219873 0.068299519341444 "CDK6 MUT" "Imatinib_IC_50" 0.892952240859119 0.975972789421281 0.108607353603604 0.992370068594779 0.9986393956939 -0.00766246477297265 0.542689205291872 0.945765861891114 0.63495807702146 "NF1 MUT" "GW843682X_IC_50" 0.259650975039358 0.723189643810247 0.809225508771932 0.992372234431331 0.9986393956939 -0.00356358578107693 0.36758474156532 0.913948248824328 0.774169412525215 "ERBB2 MUT" "GSK269962A_IC_50" 0.703521073410567 0.915500829364901 0.442849368600682 0.992453535629086 0.9986393956939 -0.0104918930695442 0.638164514028049 0.953445720127982 -0.565596458251531 "SMARCA4 MUT" "BMS.509744_IC_50" 0.910191123014412 0.981906494633752 0.113384251700682 0.992523629002869 0.9986393956939 0.00699867547413427 0.853772915116169 0.984631915507353 -0.312481837165514 "RUNX1 MUT" "GSK.650394_IC_50" 0.62970372153255 0.892582202029064 0.450654384615391 0.992604366290655 0.9986393956939 0.005581893081108 0.950763917429821 0.995668765770473 0.0638377390036688 "CDH1 MUT" "JNK.9L_IC_50" 0.214654094970585 0.688117861819268 0.572179763234443 0.992679719084083 0.9986393956939 -0.00335571356767507 0.225397047004133 0.86643108387559 0.593737037441577 "MSH6 MUT" "CGP.082996_IC_50" 0.699908492738979 0.915410639012359 -0.317356883561647 0.992967889140099 0.9988161539759 -0.00611677806195256 0.849738417726762 0.984337428855677 -0.153279719181033 "KDM6A MUT" "Vinblastine_IC_50" 0.44871545974145 0.827360921900611 -0.343489470272902 0.993498718739218 0.999090756486552 -0.00270145108078973 0.162366683297967 0.839927262232576 -0.614642834144992 "CDKN2a(p14) MUT" "Epothilone.B_IC_50" 0.0391279718652381 0.358612505815459 -0.417163558519387 0.993635243991311 0.999090756486552 -0.000964844447001805 0.917881951701386 0.992963223576061 0.0227404491074126 "TET2 MUT" "Camptothecin_IC_50" 0.0421279171700561 0.369336655861074 -2.63891873320655 0.993790428025329 0.999090756486552 0.00648418320238476 0.821103894003734 0.977383317127464 -0.319373024898729 "MDM2 MUT" "RO.3306_IC_50" 0.569925981125128 0.872389778906173 0.266647579365082 0.993888829205361 0.999090756486552 0.00342603147335263 0.589639543138288 0.949294892873838 0.251454031284649 "KRAS MUT" "Methotrexate_IC_50" 0.255458385113772 0.720311238267775 0.305545104497354 0.993940083208361 0.999090756486552 -0.00164746394201428 0.586063922050104 0.949294892873838 0.135058957554173 "MYC MUT" "GW843682X_IC_50" 0.531127022437855 0.856734402332693 -0.325076214743589 0.993947484987933 0.999090756486552 0.00208638789893919 0.255844904462328 0.875707386589409 -0.648136881045386 "CDKN2C MUT" "Roscovitine_IC_50" 0.801469038703279 0.9507092914502 -0.173470862470862 0.994028366660869 0.999090756486552 0.00457133711897 0.865386634751287 0.987077901072027 0.142051192291384 "MYCL1 MUT" "X681640_IC_50" 0.803851669555272 0.951995809685991 0.154192044496489 0.994310865278297 0.999242983255767 0.00377295229213544 0.393893984160975 0.915926348152589 0.54662108026771 "KDR MUT" "PAC.1_IC_50" 0.775416976307747 0.941591338606299 -0.285051694541226 0.994586328067177 0.999242983255767 -0.00567603421223746 0.385840784974747 0.915482770868482 -0.843852034126225 "BCR_ABL MUT" "MG.132_IC_50" 0.931110620174633 0.986689293492114 0.102891122448979 0.99465156886652 0.999242983255767 0.00891653555423347 0.886052444812663 0.988301482344111 -0.161422420556189 "SMO MUT" "CHIR.99021_IC_50" 0.94668097426683 0.990414144411092 -0.067964948275864 0.994779383843712 0.999242983255767 0.00627317478667588 0.75105817243542 0.968780465757047 -0.309850197632545 "CDKN2C MUT" "MG.132_IC_50" 0.58670376961876 0.876506729771444 -0.529968812785388 0.994866202799565 0.999242983255767 0.005559009059685 0.796630574247494 0.976360691959787 -0.283889492042268 "RUNX1 MUT" "Camptothecin_IC_50" 0.456719147514908 0.828966839128293 -0.968076591254748 0.994973818481864 0.999242983255767 -0.00516604033746717 0.402829338925534 0.916850640727267 -0.952590426843586 "ERBB2 MUT" "AMG.706_IC_50" 0.181540048692991 0.658636992153339 0.42221328796307 0.995059757607375 0.999242983255767 -0.00187587929433308 0.608823548306157 0.949923038037066 0.159284014331558 "CDK6 MUT" "EHT.1864_IC_50" 0.837603391642514 0.959212493377535 -0.0924801470588234 0.995079939636753 0.999242983255767 0.00274955206322218 0.441240860317678 0.924472815010418 -0.336223585013436 "KIT MUT" "Elesclomol_IC_50" 0.379597554282593 0.796787019518722 -0.960218887619053 0.995677674145399 0.999717436624107 0.00492342440810692 0.964891682409697 0.997126446878798 -0.0458189321606606 "KDR MUT" "ABT.263_IC_50" 0.884001172346029 0.97404645305274 0.183795683626874 0.995867030370039 0.999717436624107 0.0058777264658053 0.700063260779731 0.961100601384891 -0.425608769677456 "CDK6 MUT" "BI.D1870_IC_50" 0.455074078067895 0.828966839128293 0.404071057700556 0.995971041923801 0.999717436624107 0.00235527643340788 0.77964421289246 0.972337708041191 0.143373196146139 "FGFR2 MUT" "PF.02341066_IC_50" 0.366706174240799 0.788882799008227 0.851351989898986 0.996033094669564 0.999717436624107 0.00443152985675103 0.844611261294348 0.983349844199673 0.221236427422081 "PIK3CA MUT" "SL.0101.1_IC_50" 0.155212068702946 0.630721638230745 0.259323301472485 0.99622814848114 0.999717436624107 0.000758618058181244 0.696535359434924 0.961100601384891 0.0759402836984936 "CDKN2C MUT" "CCT018159_IC_50" 0.632369767563663 0.89399270048764 -0.278139861751151 0.996282644566539 0.999717436624107 -0.00254650830804271 0.688991532151589 0.961100601384891 -0.258880173486728 "FAM123B MUT" "Doxorubicin_IC_50" 0.332976646909012 0.773185226006147 0.847631096153856 0.996504126455633 0.999717436624107 -0.00238437874599469 0.51406528570601 0.939635632721979 0.551478998905394 "BRAF MUT" "Z.LLNle.CHO_IC_50" 0.151763659824462 0.625830613280407 -0.588111928484851 0.996560326463039 0.999717436624107 0.00177802707658528 0.562473534847928 0.949294892873838 -0.298807403765167 "IDH1 MUT" "AKT.inhibitor.VIII_IC_50" 0.923346496155505 0.98643792569589 -0.109140398275862 0.99673837493214 0.999717436624107 0.00395877673371474 0.793722855571876 0.975393509832241 -0.291518733332699 "CCND1 MUT" "Vorinostat_IC_50" 0.262652660459853 0.724847082936025 0.29061670927835 0.996781952439289 0.999717436624107 0.000804874550334482 0.690597531260181 0.961100601384891 -0.101750664031156 "FGFR3 MUT" "Z.LLNle.CHO_IC_50" 0.462533743065353 0.82931728663973 -0.945932540816329 0.996942460125588 0.999717436624107 0.00452948815643711 0.338020768816616 0.906230588643738 -1.20284185701128 "MYC MUT" "SB590885_IC_50" 0.936001677966145 0.988304708360163 -0.0240996644736839 0.99703555794869 0.999717436624107 -0.000938536104683935 0.96478936730794 0.997126446878798 0.0121295692993324 "MLL_AFF1 MUT" "Tipifarnib_IC_50" 0.168713706094437 0.647707839347554 -2.18075853739133 0.997345093347203 0.999717436624107 0.00356922066117021 0.335101239534785 0.904569637783716 -1.5132465682854 "MLLT3 MUT" "GDC0941_IC_50" 0.959405013878527 0.993456347206305 -0.0234997008456652 0.997358767239356 0.999717436624107 0.00122516402249683 0.977975038317142 0.997633392521771 -0.0134124329668495 "PIK3CA MUT" "GNF.2_IC_50" 0.67948342139382 0.90920221267664 -0.146913685512367 0.997382353689914 0.999717436624107 0.00111686228156647 0.833628383459242 0.981482581683432 -0.0832575593613777 "TET2 MUT" "AZD8055_IC_50" 0.195070325386122 0.670441006096806 -1.06425125396823 0.997550242421686 0.999717436624107 -0.00198870735098454 0.817311691583231 0.977383317127464 -0.225953078932234 "CDKN2A MUT" "RO.3306_IC_50" 0.169114693429416 0.648365181185948 -0.178847110500608 0.997624960871299 0.999717436624107 -0.000384692089822252 0.490688780909942 0.933639405738697 -0.101845428855595 "SMAD4 MUT" "AZD6482_IC_50" 0.586479602676608 0.876506729771444 0.203732760304297 0.997818940205852 0.999717436624107 -0.000890669418212058 0.913183841441776 0.99082410867764 -0.0428434371546425 "PIK3CA MUT" "IPA.3_IC_50" 0.978875889931286 0.996276778834563 -0.00781241434742607 0.997861128642981 0.999717436624107 -0.000671255777886219 0.113673199584288 0.799692247086917 -0.475482568095662 "RB1 MUT" "Nilotinib_IC_50" 0.686930987809718 0.911748124009352 -0.0918827119847711 0.997899596964733 0.999717436624107 0.000499829004480538 0.133122516169866 0.826023079873761 -0.340309724583486 "EZH2 MUT" "Lapatinib_IC_50" 0.363373759356254 0.787306955898826 0.814591423611114 0.998021569382277 0.999717436624107 0.00191431338907085 0.52431744462732 0.940554660491705 -0.57433052067814 "RUNX1 MUT" "AKT.inhibitor.VIII_IC_50" 0.437738153611403 0.823808548892323 0.558008542461001 0.998061553464245 0.999717436624107 0.00149438531767933 0.998218509421377 0.999689936809094 0.00174316450649797 "MDM2 MUT" "AZD8055_IC_50" 0.138719755392903 0.607179680994022 0.706141140562248 0.998141483002585 0.999717436624107 0.000866261648085611 0.181899221286686 0.849787998025805 0.612564858501393 "IDH1 MUT" "X17.AAG_IC_50" 0.57921613395774 0.874194311383525 -0.862159990476205 0.998330007454221 0.999757506794784 -0.00284463035521308 0.62357939896291 0.950496524771391 -0.67383232811352 "BRCA2 MUT" "NU.7441_IC_50" 0.433190154821986 0.822749994507661 0.503803003968263 0.998406635262126 0.999757506794784 -0.00113525155359083 0.814098502525429 0.977383317127464 -0.147057052993006 "BRCA1 MUT" "GW.441756_IC_50" 0.713764012880394 0.91988693852899 -0.223923817142859 0.998671926333387 0.999861499483062 -0.000997069965318121 0.834081279978605 0.981482581683432 -0.12633859736078 "FGFR3 MUT" "Lenalidomide_IC_50" 0.867167463797523 0.968231612520217 -0.12578377609108 0.998884294276842 0.999861499483062 -0.000922638965307884 0.528949099396462 0.943054040048671 -0.452507540078389 "JAK2 MUT" "GW.441756_IC_50" 0.836812766800692 0.959212493377535 0.0953272159277503 0.998998987110369 0.999861499483062 0.000568388325658021 0.556540297116447 0.948864346072406 0.293765252146512 "KDM5C MUT" "A.770041_IC_50" 0.545452707016677 0.862707523413309 -0.778056457337885 0.999120302785054 0.999861499483062 -0.00116176942821763 0.612886922870776 0.949930222127033 -0.616191041894027 "BRCA2 MUT" "KU.55933_IC_50" 0.437053114065508 0.823808548892323 0.438279444444451 0.99917145035221 0.999861499483062 -0.000525461233176723 0.816886614510532 0.977383317127464 0.129998328445785 "GNAS MUT" "Bexarotene_IC_50" 0.859308457090466 0.966322414954601 0.0908222028218695 0.999395855369101 0.999861499483062 0.00034566648455388 0.925787891478697 0.994026707431102 0.0459405624990877 "BRCA1 MUT" "Bosutinib_IC_50" 0.491610775194118 0.842990705166559 0.620251063097517 0.999557253704531 0.999861499483062 0.000411966841522777 0.846742106916184 0.98378870157398 0.160730915223995 "BRCA1 MUT" "RDEA119_IC_50" 0.742873349376614 0.929570057037101 -0.385179755467202 0.99958256300877 0.999861499483062 -0.000558391911392901 0.548002429831862 0.947060194029534 -0.600934241412746 "BCR_ABL MUT" "X681640_IC_50" 0.0685511293053665 0.463320075617169 -1.48880887067208 0.999751508924723 0.999861499483062 0.000268314579544949 0.60905374974825 0.949930222127033 -0.405757392987013 "TSC1 MUT" "X681640_IC_50" 0.561206232304963 0.870276331255523 -0.671343089249478 0.999761515802955 0.999861499483062 -0.000295469100815091 0.727657433801015 0.965402608571648 -0.377288578948377 "MLLT3 MUT" "PAC.1_IC_50" 0.614485554025457 0.885815598771911 -0.19325008384721 0.999795361923221 0.999861499483062 8.19299738073725e-05 0.922512079900855 0.993931766508607 0.0375954649975738 "RB1 MUT" "Imatinib_IC_50" 0.716119338022885 0.921050809700396 0.083350202579942 0.999861499483062 0.999861499483062 -4.09547164557973e-05 0.622823916763226 0.950496524771391 -0.139730369222904 "AKT2 MUT" "Erlotinib_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Erlotinib_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "Erlotinib_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Erlotinib_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "Erlotinib_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "Erlotinib_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "Erlotinib_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "Erlotinib_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "Erlotinib_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "Erlotinib_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Erlotinib_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Erlotinib_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Erlotinib_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Erlotinib_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "Erlotinib_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Rapamycin_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "Rapamycin_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Rapamycin_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "Rapamycin_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "Rapamycin_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "Rapamycin_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "Rapamycin_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "Rapamycin_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "Rapamycin_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Rapamycin_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Rapamycin_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Rapamycin_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "Rapamycin_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "Sunitinib_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Sunitinib_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "Sunitinib_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Sunitinib_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "Sunitinib_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "Sunitinib_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "Sunitinib_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "Sunitinib_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "Sunitinib_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "Sunitinib_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Sunitinib_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Sunitinib_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Sunitinib_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "Sunitinib_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "PHA.665752_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "PHA.665752_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "PHA.665752_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "PHA.665752_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "PHA.665752_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "PHA.665752_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "PHA.665752_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "PHA.665752_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "PHA.665752_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "PHA.665752_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "PHA.665752_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "PHA.665752_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "PHA.665752_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "MG.132_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "MG.132_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "MG.132_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "MG.132_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "MG.132_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "MG.132_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "MG.132_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "MG.132_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "MG.132_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "MG.132_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "MG.132_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "MG.132_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "MG.132_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "Paclitaxel_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Paclitaxel_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "Paclitaxel_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Paclitaxel_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "Paclitaxel_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "Paclitaxel_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "Paclitaxel_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "Paclitaxel_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "Paclitaxel_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "Paclitaxel_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Paclitaxel_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Paclitaxel_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Paclitaxel_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "Paclitaxel_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "Cyclopamine_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Cyclopamine_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "Cyclopamine_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Cyclopamine_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "Cyclopamine_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "Cyclopamine_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "Cyclopamine_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "Cyclopamine_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "Cyclopamine_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "Cyclopamine_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Cyclopamine_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Cyclopamine_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Cyclopamine_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "Cyclopamine_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "AZ628_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "AZ628_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "AZ628_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "AZ628_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "AZ628_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "AZ628_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "AZ628_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "AZ628_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "AZ628_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "AZ628_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "AZ628_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "AZ628_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "AZ628_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "AZ628_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Sorafenib_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "Sorafenib_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Sorafenib_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "Sorafenib_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "Sorafenib_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "Sorafenib_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "Sorafenib_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "Sorafenib_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "Sorafenib_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Sorafenib_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Sorafenib_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Sorafenib_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "Sorafenib_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "VX.680_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "VX.680_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "VX.680_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "VX.680_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "VX.680_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "VX.680_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "VX.680_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "VX.680_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "VX.680_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "VX.680_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "VX.680_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "VX.680_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "VX.680_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "VX.680_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Imatinib_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "Imatinib_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Imatinib_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "Imatinib_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "Imatinib_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "Imatinib_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "Imatinib_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "Imatinib_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "Imatinib_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Imatinib_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Imatinib_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Imatinib_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "Imatinib_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "NVP.TAE684_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "NVP.TAE684_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "NVP.TAE684_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "NVP.TAE684_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "NVP.TAE684_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "NVP.TAE684_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "NVP.TAE684_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "NVP.TAE684_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "NVP.TAE684_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "NVP.TAE684_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "NVP.TAE684_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "NVP.TAE684_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "NVP.TAE684_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "PF.02341066_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "PF.02341066_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "PF.02341066_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "PF.02341066_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "PF.02341066_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "PF.02341066_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "PF.02341066_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "PF.02341066_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "PF.02341066_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "PF.02341066_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "PF.02341066_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "PF.02341066_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "PF.02341066_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "AZD.0530_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "AZD.0530_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "AZD.0530_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "AZD.0530_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "AZD.0530_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "AZD.0530_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "AZD.0530_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "AZD.0530_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "AZD.0530_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "AZD.0530_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "AZD.0530_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "AZD.0530_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "AZD.0530_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "S.Trityl.L.cysteine_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "S.Trityl.L.cysteine_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "S.Trityl.L.cysteine_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "S.Trityl.L.cysteine_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "S.Trityl.L.cysteine_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "S.Trityl.L.cysteine_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "S.Trityl.L.cysteine_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "S.Trityl.L.cysteine_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "S.Trityl.L.cysteine_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "S.Trityl.L.cysteine_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "S.Trityl.L.cysteine_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "S.Trityl.L.cysteine_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "S.Trityl.L.cysteine_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "S.Trityl.L.cysteine_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "Z.LLNle.CHO_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Z.LLNle.CHO_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "Z.LLNle.CHO_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Z.LLNle.CHO_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "Z.LLNle.CHO_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "Z.LLNle.CHO_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "Z.LLNle.CHO_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "Z.LLNle.CHO_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "Z.LLNle.CHO_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "Z.LLNle.CHO_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Z.LLNle.CHO_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Z.LLNle.CHO_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Z.LLNle.CHO_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "Z.LLNle.CHO_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "Dasatinib_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Dasatinib_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "Dasatinib_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Dasatinib_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "Dasatinib_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "Dasatinib_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "Dasatinib_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "Dasatinib_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "Dasatinib_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "Dasatinib_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Dasatinib_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Dasatinib_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Dasatinib_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "Dasatinib_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "GNF.2_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "GNF.2_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "GNF.2_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "GNF.2_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "GNF.2_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "GNF.2_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "GNF.2_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "GNF.2_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "GNF.2_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "GNF.2_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "GNF.2_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "GNF.2_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "GNF.2_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "GNF.2_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "CGP.60474_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "CGP.60474_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "CGP.60474_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "CGP.60474_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "CGP.60474_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "CGP.60474_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "CGP.60474_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "CGP.60474_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "CGP.60474_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "CGP.60474_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "CGP.60474_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "CGP.60474_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "CGP.60474_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "CGP.60474_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "CGP.082996_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "CGP.082996_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "CGP.082996_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "CGP.082996_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "CGP.082996_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "CGP.082996_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "CGP.082996_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "CGP.082996_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "CGP.082996_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "CGP.082996_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "CGP.082996_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "CGP.082996_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "CGP.082996_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "CGP.082996_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "A.770041_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "A.770041_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "A.770041_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "A.770041_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "A.770041_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "A.770041_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "A.770041_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "A.770041_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "A.770041_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "A.770041_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "A.770041_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "A.770041_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "A.770041_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "A.770041_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "WH.4.023_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "WH.4.023_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "WH.4.023_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "WH.4.023_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "WH.4.023_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "WH.4.023_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "WH.4.023_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "WH.4.023_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "WH.4.023_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "WH.4.023_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "WH.4.023_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "WH.4.023_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "WH.4.023_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "WH.4.023_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "WZ.1.84_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "WZ.1.84_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "WZ.1.84_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "WZ.1.84_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "WZ.1.84_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "WZ.1.84_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "WZ.1.84_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "WZ.1.84_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "WZ.1.84_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "WZ.1.84_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "WZ.1.84_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "WZ.1.84_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "WZ.1.84_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "WZ.1.84_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "BI.2536_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "BI.2536_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "BI.2536_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "BI.2536_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "BI.2536_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "BI.2536_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "BI.2536_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "BI.2536_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "BI.2536_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "BI.2536_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "BI.2536_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "BI.2536_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "BI.2536_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "BI.2536_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "BMS.536924_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "BMS.536924_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "BMS.536924_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "BMS.536924_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "BMS.536924_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "BMS.536924_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "BMS.536924_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "BMS.536924_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "BMS.536924_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "BMS.536924_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "BMS.536924_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "BMS.536924_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "BMS.536924_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "BMS.536924_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "BMS.509744_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "BMS.509744_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "BMS.509744_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "BMS.509744_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "BMS.509744_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "BMS.509744_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "BMS.509744_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "BMS.509744_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "BMS.509744_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "BMS.509744_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "BMS.509744_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "BMS.509744_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "BMS.509744_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "BMS.509744_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "CMK_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "CMK_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "CMK_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "CMK_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "CMK_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "CMK_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "CMK_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "CMK_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "CMK_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "CMK_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "CMK_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "CMK_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "CMK_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "CMK_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Pyrimethamine_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "Pyrimethamine_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Pyrimethamine_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "Pyrimethamine_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "Pyrimethamine_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "Pyrimethamine_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "Pyrimethamine_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "Pyrimethamine_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "Pyrimethamine_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Pyrimethamine_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Pyrimethamine_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Pyrimethamine_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "Pyrimethamine_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "JW.7.52.1_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "JW.7.52.1_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "JW.7.52.1_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "JW.7.52.1_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "JW.7.52.1_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "JW.7.52.1_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "JW.7.52.1_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "JW.7.52.1_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "JW.7.52.1_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "JW.7.52.1_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "JW.7.52.1_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "JW.7.52.1_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "JW.7.52.1_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "JW.7.52.1_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "A.443654_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "A.443654_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "A.443654_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "A.443654_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "A.443654_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "A.443654_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "A.443654_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "A.443654_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "A.443654_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "A.443654_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "A.443654_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "A.443654_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "A.443654_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "A.443654_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "GW843682X_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "GW843682X_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "GW843682X_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "GW843682X_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "GW843682X_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "GW843682X_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "GW843682X_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "GW843682X_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "GW843682X_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "GW843682X_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "GW843682X_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "GW843682X_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "GW843682X_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "GW843682X_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "MS.275_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "MS.275_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "MS.275_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "MS.275_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "MS.275_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "MS.275_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "MS.275_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "MS.275_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "MS.275_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "MS.275_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "MS.275_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "MS.275_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "MS.275_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "MS.275_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Parthenolide_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "Parthenolide_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Parthenolide_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "Parthenolide_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "Parthenolide_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "Parthenolide_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "Parthenolide_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "Parthenolide_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "Parthenolide_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Parthenolide_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Parthenolide_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Parthenolide_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "Parthenolide_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "KIN001.135_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "KIN001.135_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "KIN001.135_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "KIN001.135_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "KIN001.135_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "KIN001.135_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "KIN001.135_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "KIN001.135_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "KIN001.135_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "KIN001.135_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "KIN001.135_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "KIN001.135_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "KIN001.135_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Bortezomib_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "Bortezomib_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Bortezomib_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "Bortezomib_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "Bortezomib_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "Bortezomib_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "Bortezomib_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "Bortezomib_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "Bortezomib_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Bortezomib_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Bortezomib_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Bortezomib_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Bortezomib_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "Bortezomib_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "XMD8.85_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "XMD8.85_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "XMD8.85_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "XMD8.85_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "XMD8.85_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "XMD8.85_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "XMD8.85_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "XMD8.85_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "XMD8.85_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "XMD8.85_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "XMD8.85_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "XMD8.85_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "XMD8.85_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "XMD8.85_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "Roscovitine_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Roscovitine_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "Roscovitine_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Roscovitine_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "Roscovitine_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "Roscovitine_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "Roscovitine_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "Roscovitine_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "Roscovitine_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "Roscovitine_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Roscovitine_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Roscovitine_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Roscovitine_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Roscovitine_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "Roscovitine_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "Salubrinal_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Salubrinal_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "Salubrinal_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Salubrinal_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "Salubrinal_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "Salubrinal_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "Salubrinal_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "Salubrinal_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "Salubrinal_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "Salubrinal_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Salubrinal_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Salubrinal_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Salubrinal_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "Salubrinal_IC_50" NA NA NA NA NA NA NA NA NA "AKT2 MUT" "Lapatinib_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Lapatinib_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "Lapatinib_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Lapatinib_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "Lapatinib_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "Lapatinib_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "Lapatinib_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "Lapatinib_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "Lapatinib_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "Lapatinib_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Lapatinib_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Lapatinib_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Lapatinib_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Lapatinib_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "Lapatinib_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "GSK269962A_IC_50" NA NA NA NA NA NA NA NA NA "CCND3 MUT" "GSK269962A_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "GSK269962A_IC_50" NA NA NA NA NA NA NA NA NA "FAM123B MUT" "GSK269962A_IC_50" NA NA NA NA NA NA NA NA NA "HRAS MUT" "GSK269962A_IC_50" NA NA NA NA NA NA NA NA NA "IDH1 MUT" "GSK269962A_IC_50" NA NA NA NA NA NA NA NA NA "KDR MUT" "GSK269962A_IC_50" NA NA NA NA NA NA NA NA NA "PDGFRA MUT" "GSK269962A_IC_50" NA NA NA NA NA NA NA NA NA "RUNX1 MUT" "GSK269962A_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "GSK269962A_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "GSK269962A_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "GSK269962A_IC_50" NA NA NA NA NA NA NA NA NA "TSC1 MUT" "GSK269962A_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Doxorubicin_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Doxorubicin_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Etoposide_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Etoposide_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Gemcitabine_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Gemcitabine_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Mitomycin.C_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Mitomycin.C_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Vinorelbine_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Vinorelbine_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "NSC.87877_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "NSC.87877_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Bicalutamide_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Bicalutamide_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "QS11_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "QS11_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Midostaurin_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Midostaurin_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "CHIR.99021_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "CHIR.99021_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "AP.24534_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "AP.24534_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "AZD6482_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "AZD6482_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "JNK.9L_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "JNK.9L_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "PF.562271_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "PF.562271_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "DMOG_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "DMOG_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "FTI.277_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "FTI.277_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Shikonin_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Shikonin_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "AKT.inhibitor.VIII_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "AKT.inhibitor.VIII_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Embelin_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Embelin_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "FH535_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "FH535_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "PAC.1_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "PAC.1_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "IPA.3_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "IPA.3_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "GSK.650394_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "GSK.650394_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "BAY.61.3606_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "BAY.61.3606_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Thapsigargin_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Thapsigargin_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Obatoclax.Mesylate_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Obatoclax.Mesylate_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "BMS.754807_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "BMS.754807_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "OSI.906_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "OSI.906_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Bexarotene_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Bexarotene_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Bleomycin_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Bleomycin_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "LFM.A13_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "LFM.A13_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "AUY922_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "AUY922_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Bryostatin.1_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Bryostatin.1_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Pazopanib_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Pazopanib_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Epothilone.B_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Epothilone.B_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Tipifarnib_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Tipifarnib_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "AS601245_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "AS601245_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Metformin_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Metformin_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Metformin_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Metformin_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "AICAR_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "AICAR_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "AICAR_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "AICAR_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "AICAR_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Camptothecin_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Camptothecin_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Camptothecin_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Camptothecin_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Vinblastine_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Vinblastine_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Vinblastine_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Vinblastine_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Cisplatin_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Cisplatin_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Cisplatin_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Cisplatin_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Cytarabine_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Cytarabine_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Cytarabine_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Cytarabine_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Docetaxel_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Docetaxel_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Docetaxel_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Docetaxel_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Docetaxel_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Methotrexate_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Methotrexate_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Methotrexate_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Methotrexate_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Methotrexate_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "Methotrexate_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "ATRA_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "ATRA_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "ATRA_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "ATRA_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "ATRA_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Gefitinib_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Gefitinib_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Gefitinib_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Gefitinib_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "ABT.263_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "ABT.263_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "ABT.263_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "ABT.263_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Vorinostat_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Vorinostat_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Vorinostat_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Vorinostat_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "Vorinostat_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Nilotinib_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Nilotinib_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Nilotinib_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Nilotinib_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "RDEA119_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "RDEA119_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "RDEA119_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "RDEA119_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "CI.1040_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "CI.1040_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "CI.1040_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "CI.1040_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Temsirolimus_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Temsirolimus_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Temsirolimus_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Temsirolimus_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "AZD.2281_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "AZD.2281_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "AZD.2281_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "AZD.2281_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "AZD.2281_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "ABT.888_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "ABT.888_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "ABT.888_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "ABT.888_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Bosutinib_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Bosutinib_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Bosutinib_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Bosutinib_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Lenalidomide_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Lenalidomide_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Lenalidomide_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Lenalidomide_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Axitinib_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Axitinib_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Axitinib_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Axitinib_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "AZD7762_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "AZD7762_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "AZD7762_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "AZD7762_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "GW.441756_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "GW.441756_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "GW.441756_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "GW.441756_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "CEP.701_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "CEP.701_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "CEP.701_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "CEP.701_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "SB.216763_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "SB.216763_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "SB.216763_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "SB.216763_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "SB.216763_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "X17.AAG_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "X17.AAG_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "X17.AAG_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "VX.702_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "VX.702_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "VX.702_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "VX.702_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "VX.702_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "AMG.706_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "AMG.706_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "AMG.706_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "AMG.706_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "KU.55933_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "KU.55933_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "KU.55933_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "KU.55933_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "Elesclomol_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "Elesclomol_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "Elesclomol_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "Elesclomol_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "BIBW2992_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "BIBW2992_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "BIBW2992_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "BIBW2992_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "GDC.0449_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "GDC.0449_IC_50" NA NA NA NA NA NA NA NA NA "SETD2 MUT" "GDC.0449_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "GDC.0449_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "GDC.0449_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "PLX4720_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "PLX4720_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "PLX4720_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "PLX4720_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "BX.795_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "BX.795_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "BX.795_IC_50" NA NA NA NA NA NA NA NA NA "SMO MUT" "BX.795_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "BX.795_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "NU.7441_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "NU.7441_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "NU.7441_IC_50" NA NA NA NA NA NA NA NA NA "SOCS1 MUT" "NU.7441_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "SL.0101.1_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "SL.0101.1_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "SL.0101.1_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "BI.D1870_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" "BI.D1870_IC_50" NA NA NA NA NA NA NA NA NA "SMARCB1 MUT" "BI.D1870_IC_50" NA NA NA NA NA NA NA NA NA "CCND2 MUT" "BIRB.0796_IC_50" NA NA NA NA NA NA NA NA NA "CYLD MUT" 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