$PROBLEM    2-COMP Model with Prop Error and FOCE w/ INTER and
;           Only IIV on Clearance and Q assumed
$INPUT      C ID EVID MDV TIME DV AMT RATE ISM AGE WT SCR CRCL 
$DATA      Vanco_sample.csv IGNORE=C
$SUBROUTINE ADVAN3 TRANS4

$PK

V1WT = ( 1 + THETA(6)*(WT - 94.5))
V1COV=V1WT 

V2WT = ( 1 + THETA(7)*(WT - 94.5))
V2COV = V2WT

CLCRCL = ( 1 + THETA(5)*(CRCL - 83))
CLCOV=CLCRCL

TVV1 = THETA(1)
TVV1 = V1COV*TVV1
V1 = TVV1 * EXP(ETA(1))

TVCL = THETA(2) 
TVCL = CLCOV*TVCL
CL = TVCL * EXP(ETA(2))

TVQ = THETA(3) 
Q = TVQ * EXP(ETA(3))

TVV2 = THETA(4) * V2WT 
V2 = TVV2 * EXP(ETA(4))

S1 = V1
S2 = V2 

$ERROR 
Y = F * (1 + EPS(1))
IPRED = F
IRES = DV-IPRED
IWRES = IRES

$THETA
(0, 26.5) ; V1
(0, 2.87) ; CL
(0, 12) ; Q
(0, 39) ; V2
(0, 0.0313) ; CLCRCL1
(0, 0.00817) ; V1WT1
(0, 0.0233,0.03) ; V2WT1

$OMEGA
 0.0755
 0.842
 0 FIX 
 0 FIX 

$SIGMA 0.00695
;MSFI=./.msf

$ESTIMATION MAXEVAL=9999 PRINT=5 METHOD=1 INTER POSTHOC MSFO=./321.msf
$COVARIANCE PRINT=E

; Xpose
$TABLE ID TIME DV MDV EVID IPRED IWRES CWRES ONEHEADER NOPRINT FILE=sdtab321
$TABLE ID CL V1 V2 Q ETA1 ONEHEADER NOPRINT FILE=patab321
$TABLE ID WT CRCL AGE SCR ONEHEADER NOPRINT FILE=cotab321
$TABLE ID ISM ONEHEADER NOPRINT FILE=catab321