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["S16. HKA GO enrichment results - G.g. gorilla balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["biological process","interferon-gamma-mediated signaling pathway","GO:0060333"]
["C=74;O=11;E=0.33;R=33.48;rawP=1.80e-14;adjP=6.86e-12"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["GBP1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","cellular response to interferon-gamma","GO:0071346"]
["C=89;O=11;E=0.40;R=27.84;rawP=1.50e-13;adjP=5.72e-11"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["GBP1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","response to interferon-gamma","GO:0034341"]
["C=108;O=11;E=0.48;R=22.94;rawP=1.33e-12;adjP=5.07e-10"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["GBP1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","antigen processing and presentation of exogenous peptide antigen via MHC class II","GO:0019886"]
["C=91;O=10;E=0.40;R=24.75;rawP=6.94e-12;adjP=2.64e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["DYNC2H1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of exogenous peptide antigen","GO:0002478"]
["C=167;O=12;E=0.74;R=16.18;rawP=7.66e-12;adjP=2.92e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["DYNC2H1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","antigen processing and presentation","GO:0019882"]
["C=215;O=13;E=0.95;R=13.62;rawP=8.45e-12;adjP=3.22e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["MICA"]
["DYNC2H1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","antigen processing and presentation of exogenous antigen","GO:0019884"]
["C=169;O=12;E=0.75;R=15.99;rawP=8.82e-12;adjP=3.36e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["DYNC2H1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","antigen processing and presentation of peptide antigen via MHC class II","GO:0002495"]
["C=94;O=10;E=0.42;R=23.96;rawP=9.66e-12;adjP=3.68e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["DYNC2H1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of peptide or polysaccharide antigen via MHC class II","GO:0002504"]
["C=95;O=10;E=0.42;R=23.71;rawP=1.08e-11;adjP=4.11e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["DYNC2H1"]
["HLA-DPB1"]
["biological process","exogen","GO:0042638"]
["C=178;O=12;E=0.79;R=15.18;rawP=1.63e-11;adjP=6.21e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["DYNC2H1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","antigen processing and presentation of peptide antigen","GO:0048002"]
["C=185;O=12;E=0.82;R=14.61;rawP=2.56e-11;adjP=9.75e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["DYNC2H1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","hair follicle maturation","GO:0048820"]
["C=192;O=12;E=0.85;R=14.08;rawP=3.96e-11;adjP=1.51e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["DYNC2H1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","anatomical structure maturation","GO:0071695"]
["C=217;O=12;E=0.96;R=12.46;rawP=1.65e-10;adjP=6.29e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["DYNC2H1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","T cell costimulation","GO:0031295"]
["C=67;O=8;E=0.30;R=26.89;rawP=5.10e-10;adjP=1.94e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","lymphocyte costimulation","GO:0031294"]
["C=68;O=8;E=0.30;R=26.50;rawP=5.76e-10;adjP=2.19e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","hair follicle development","GO:0001942"]
["C=256;O=12;E=1.14;R=10.56;rawP=1.10e-09;adjP=4.19e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["DYNC2H1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","hair cycle process","GO:0022405"]
["C=256;O=12;E=1.14;R=10.56;rawP=1.10e-09;adjP=4.19e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["DYNC2H1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","molting cycle process","GO:0022404"]
["C=256;O=12;E=1.14;R=10.56;rawP=1.10e-09;adjP=4.19e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["DYNC2H1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","hair cycle","GO:0042633"]
["C=262;O=12;E=1.16;R=10.32;rawP=1.43e-09;adjP=5.45e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["DYNC2H1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","molting cycle","GO:0042303"]
["C=262;O=12;E=1.16;R=10.32;rawP=1.43e-09;adjP=5.45e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["DYNC2H1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","immune response-activating cell surface receptor signaling pathway","GO:0002429"]
["C=126;O=9;E=0.56;R=16.09;rawP=4.10e-09;adjP=1.56e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["MICA"]
["HLA-DPB1"]
["biological process","T cell receptor signaling pathway","GO:0050852"]
["C=93;O=8;E=0.41;R=19.38;rawP=7.28e-09;adjP=2.77e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","immune response-regulating cell surface receptor signaling pathway","GO:0002768"]
["C=137;O=9;E=0.61;R=14.80;rawP=8.59e-09;adjP=3.27e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["MICA"]
["HLA-DPB1"]
["biological process","developmental maturation","GO:0021700"]
["C=349;O=12;E=1.55;R=7.74;rawP=3.56e-08;adjP=1.36e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["DYNC2H1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","antigen receptor-mediated signaling pathway","GO:0050851"]
["C=117;O=8;E=0.52;R=15.40;rawP=4.48e-08;adjP=1.71e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","epidermis development","GO:0008544"]
["C=454;O=13;E=2.02;R=6.45;rawP=7.68e-08;adjP=2.93e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["EVPL"]
["DYNC2H1"]
["HLA-DPB1"]
["HLA-A"]
["biological process","cytokine-mediated signaling pathway","GO:0019221"]
["C=338;O=11;E=1.50;R=7.33;rawP=2.45e-07;adjP=9.33e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["GBP1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","positive regulation of T cell activation","GO:0050870"]
["C=165;O=8;E=0.73;R=10.92;rawP=6.38e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","immune response-activating signal transduction","GO:0002757"]
["C=229;O=9;E=1.02;R=8.85;rawP=7.10e-07;adjP=0.0003"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["MICA"]
["HLA-DPB1"]
["biological process","immune response-regulating signaling pathway","GO:0002764"]
["C=242;O=9;E=1.07;R=8.38;rawP=1.13e-06;adjP=0.0004"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["MICA"]
["HLA-DPB1"]
["biological process","cellular response to cytokine stimulus","GO:0071345"]
["C=410;O=11;E=1.82;R=6.04;rawP=1.65e-06;adjP=0.0006"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["GBP1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","innate immune response","GO:0045087"]
["C=516;O=12;E=2.29;R=5.24;rawP=2.34e-06;adjP=0.0009"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["GBP1"]
["MICA"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","activation of immune response","GO:0002253"]
["C=278;O=9;E=1.23;R=7.29;rawP=3.53e-06;adjP=0.0013"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["MICA"]
["HLA-DPB1"]
["biological process","positive regulation of lymphocyte activation","GO:0051251"]
["C=209;O=8;E=0.93;R=8.62;rawP=3.77e-06;adjP=0.0014"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","regulation of T cell activation","GO:0050863"]
["C=219;O=8;E=0.97;R=8.23;rawP=5.32e-06;adjP=0.0020"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","positive regulation of leukocyte activation","GO:0002696"]
["C=228;O=8;E=1.01;R=7.90;rawP=7.15e-06;adjP=0.0027"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","positive regulation of cell activation","GO:0050867"]
["C=236;O=8;E=1.05;R=7.64;rawP=9.21e-06;adjP=0.0035"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","response to cytokine stimulus","GO:0034097"]
["C=505;O=11;E=2.24;R=4.91;rawP=1.21e-05;adjP=0.0046"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["GBP1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","T cell activation","GO:0042110"]
["C=332;O=9;E=1.47;R=6.11;rawP=1.48e-05;adjP=0.0056"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["MICA"]
["HLA-DPB1"]
["biological process","regulation of immune response","GO:0050776"]
["C=528;O=11;E=2.34;R=4.69;rawP=1.83e-05;adjP=0.0070"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["MICA"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["molecular function",null,"GO:0032395"]
["C=11;O=7;E=0.04;R=159.00;rawP=3.73e-15;adjP=3.36e-13"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["molecular function","olfactory receptor activity","GO:0004984"]
["C=377;O=11;E=1.51;R=7.29;rawP=2.50e-07;adjP=2.25e-05"]
["OR5H14"]
["OR10A2"]
["OR52M1"]
["OR52J3"]
["OR51B6"]
["OR4K2"]
["OR10A4"]
["OR5H15"]
["OR51B4"]
["OR2D2"]
["OR10A5"]
["molecular function","transmembrane signaling receptor activity","GO:0004888"]
["C=1184;O=14;E=4.74;R=2.95;rawP=0.0002;adjP=0.0180"]
["OR5H14"]
["OR10A2"]
["OR52M1"]
["OR52J3"]
["OR51B6"]
["OR4K2"]
["DDR2"]
["OR10A4"]
["OR5H15"]
["OR2D2"]
["OR51B4"]
["HLA-C"]
["OR10A5"]
["HLA-A"]
["molecular function","ammonium transmembrane transporter activity","GO:0008519"]
["C=5;O=2;E=0.02;R=99.94;rawP=0.0002;adjP=0.0180"]
["RHCE"]
["RHD"]
["molecular function","G-protein coupled receptor activity","GO:0004930"]
["C=816;O=11;E=3.27;R=3.37;rawP=0.0003;adjP=0.0270"]
["OR5H14"]
["OR10A2"]
["OR52M1"]
["OR52J3"]
["OR51B6"]
["OR4K2"]
["OR10A4"]
["OR5H15"]
["OR51B4"]
["OR2D2"]
["OR10A5"]
["molecular function","signaling receptor activity","GO:0038023"]
["C=1278;O=14;E=5.12;R=2.74;rawP=0.0004;adjP=0.0360"]
["OR5H14"]
["OR10A2"]
["OR52M1"]
["OR52J3"]
["OR51B6"]
["OR4K2"]
["DDR2"]
["OR10A4"]
["OR5H15"]
["OR2D2"]
["OR51B4"]
["HLA-C"]
["OR10A5"]
["HLA-A"]
["cellular component","ER to Golgi transport vesicle membrane","GO:0012507"]
["C=36;O=11;E=0.16;R=67.11;rawP=4.50e-18;adjP=5.76e-16"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","MHC protein complex","GO:0042611"]
["C=37;O=11;E=0.17;R=65.29;rawP=6.38e-18;adjP=8.17e-16"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["MICA"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","integral to lumenal side of endoplasmic reticulum membrane","GO:0071556"]
["C=27;O=10;E=0.12;R=81.34;rawP=1.64e-17;adjP=2.10e-15"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","ER to Golgi transport vesicle","GO:0030134"]
["C=40;O=11;E=0.18;R=60.40;rawP=1.71e-17;adjP=2.19e-15"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","MHC class II protein complex","GO:0042613"]
["C=15;O=8;E=0.07;R=117.13;rawP=7.93e-16;adjP=1.02e-13"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","transport vesicle membrane","GO:0030658"]
["C=75;O=11;E=0.34;R=32.21;rawP=3.19e-14;adjP=4.08e-12"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","trans-Golgi network membrane","GO:0032588"]
["C=30;O=8;E=0.14;R=58.56;rawP=6.83e-13;adjP=8.74e-11"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","clathrin-coated endocytic vesicle membrane","GO:0030669"]
["C=32;O=8;E=0.15;R=54.90;rawP=1.22e-12;adjP=1.56e-10"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","coated vesicle membrane","GO:0030662"]
["C=149;O=12;E=0.68;R=17.69;rawP=3.11e-12;adjP=3.98e-10"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["SYNPR"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","clathrin-coated endocytic vesicle","GO:0045334"]
["C=37;O=8;E=0.17;R=47.49;rawP=4.39e-12;adjP=5.62e-10"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","endocytic vesicle membrane","GO:0030666"]
["C=92;O=10;E=0.42;R=23.87;rawP=1.11e-11;adjP=1.42e-09"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","integral to endoplasmic reticulum membrane","GO:0030176"]
["C=105;O=10;E=0.48;R=20.92;rawP=4.24e-11;adjP=5.43e-09"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","transport vesicle","GO:0030133"]
["C=144;O=11;E=0.66;R=16.78;rawP=4.75e-11;adjP=6.08e-09"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","intrinsic to endoplasmic reticulum membrane","GO:0031227"]
["C=122;O=10;E=0.56;R=18.00;rawP=1.90e-10;adjP=2.43e-08"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","endocytic vesicle","GO:0030139"]
["C=148;O=10;E=0.67;R=14.84;rawP=1.28e-09;adjP=1.64e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","coated vesicle","GO:0030135"]
["C=253;O=12;E=1.15;R=10.42;rawP=1.49e-09;adjP=1.91e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["SYNPR"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","clathrin-coated vesicle membrane","GO:0030665"]
["C=109;O=9;E=0.50;R=18.13;rawP=1.53e-09;adjP=1.96e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["SYNPR"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","integral to organelle membrane","GO:0031301"]
["C=205;O=11;E=0.93;R=11.78;rawP=2.09e-09;adjP=2.68e-07"]
["ST8SIA6"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","intrinsic to organelle membrane","GO:0031300"]
["C=227;O=11;E=1.03;R=10.64;rawP=6.09e-09;adjP=7.80e-07"]
["ST8SIA6"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","cytoplasmic vesicle membrane","GO:0030659"]
["C=340;O=12;E=1.55;R=7.75;rawP=4.05e-08;adjP=5.18e-06"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["SYNPR"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","vesicle membrane","GO:0012506"]
["C=353;O=12;E=1.61;R=7.47;rawP=6.11e-08;adjP=7.82e-06"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["SYNPR"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","trans-Golgi network","GO:0005802"]
["C=126;O=8;E=0.57;R=13.94;rawP=1.03e-07;adjP=1.32e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","Golgi membrane","GO:0000139"]
["C=547;O=14;E=2.49;R=5.62;rawP=1.48e-07;adjP=1.89e-05"]
["ST8SIA6"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["SEC23A"]
["CLSTN3"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["GBP1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","lysosomal membrane","GO:0005765"]
["C=139;O=8;E=0.63;R=12.64;rawP=2.21e-07;adjP=2.83e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","cytoplasmic vesicle part","GO:0044433"]
["C=398;O=12;E=1.81;R=6.62;rawP=2.24e-07;adjP=2.87e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["SYNPR"]
["SEC23A"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","Golgi apparatus part","GO:0044431"]
["C=661;O=15;E=3.01;R=4.98;rawP=2.37e-07;adjP=3.03e-05"]
["ST8SIA6"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["SEC23A"]
["CLSTN3"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["GBP1"]
["HLA-C"]
["MUC21"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","clathrin-coated vesicle","GO:0030136"]
["C=206;O=9;E=0.94;R=9.59;rawP=3.89e-07;adjP=4.98e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["SYNPR"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","endosome membrane","GO:0010008"]
["C=311;O=10;E=1.42;R=7.06;rawP=1.40e-06;adjP=0.0002"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","endosomal part","GO:0044440"]
["C=320;O=10;E=1.46;R=6.86;rawP=1.82e-06;adjP=0.0002"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","vacuolar membrane","GO:0005774"]
["C=182;O=8;E=0.83;R=9.65;rawP=1.72e-06;adjP=0.0002"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","vacuolar part","GO:0044437"]
["C=251;O=9;E=1.14;R=7.87;rawP=2.02e-06;adjP=0.0003"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["GALC"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","plasma membrane","GO:0005886"]
["C=4193;O=36;E=19.09;R=1.89;rawP=2.18e-05;adjP=0.0028"]
["HLA-DRA"]
["OR5H14"]
["RHCE"]
["PCDH15"]
["RHD"]
["DDR2"]
["OR5H15"]
["OR51B4"]
["HSD17B7"]
["HLA-DPB1"]
["HLA-A"]
["CD320"]
["HLA-DRB1"]
["HLA-DPA1"]
["OR52M1"]
["HLA-DQB1"]
["OR4K2"]
["SCN9A"]
["GNG13"]
["OR2D2"]
["DYNC2H1"]
["HLA-C"]
["OR10A2"]
["HLA-DQA2"]
["CLSTN3"]
["HLA-DQA1"]
["OR52J3"]
["OR51B6"]
["MICA"]
["HLA-DQB2"]
["ADCY8"]
["OR10A4"]
["SNTG1"]
["PARVG"]
["OR10A5"]
["MUC21"]
["cellular component","lysosome","GO:0005764"]
["C=341;O=9;E=1.55;R=5.80;rawP=2.38e-05;adjP=0.0030"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["GALC"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","lytic vacuole","GO:0000323"]
["C=341;O=9;E=1.55;R=5.80;rawP=2.38e-05;adjP=0.0030"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["GALC"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","cell periphery","GO:0071944"]
["C=4281;O=36;E=19.49;R=1.85;rawP=3.54e-05;adjP=0.0045"]
["HLA-DRA"]
["OR5H14"]
["RHCE"]
["PCDH15"]
["RHD"]
["DDR2"]
["OR5H15"]
["OR51B4"]
["HSD17B7"]
["HLA-DPB1"]
["HLA-A"]
["CD320"]
["HLA-DRB1"]
["HLA-DPA1"]
["OR52M1"]
["HLA-DQB1"]
["OR4K2"]
["SCN9A"]
["GNG13"]
["OR2D2"]
["DYNC2H1"]
["HLA-C"]
["OR10A2"]
["HLA-DQA2"]
["CLSTN3"]
["HLA-DQA1"]
["OR52J3"]
["OR51B6"]
["MICA"]
["HLA-DQB2"]
["ADCY8"]
["OR10A4"]
["SNTG1"]
["PARVG"]
["OR10A5"]
["MUC21"]
["cellular component","endoplasmic reticulum membrane","GO:0005789"]
["C=765;O=13;E=3.48;R=3.73;rawP=3.75e-05;adjP=0.0048"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["SEC23A"]
["CLSTN3"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HSD17B7"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","nuclear outer membrane-endoplasmic reticulum membrane network","GO:0042175"]
["C=782;O=13;E=3.56;R=3.65;rawP=4.70e-05;adjP=0.0060"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["SEC23A"]
["CLSTN3"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-C"]
["HSD17B7"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","Golgi apparatus","GO:0005794"]
["C=1163;O=16;E=5.30;R=3.02;rawP=5.62e-05;adjP=0.0072"]
["HLA-DRA"]
["HLA-DQA2"]
["SEC23A"]
["CLSTN3"]
["HLA-DQA1"]
["HLA-DPB1"]
["HLA-A"]
["HLA-DPA1"]
["HLA-DRB1"]
["ST8SIA6"]
["HLA-DQB1"]
["GBP1"]
["HLA-DQB2"]
["HLA-C"]
["DYNC2H1"]
["MUC21"]
["cellular component","vacuole","GO:0005773"]
["C=403;O=9;E=1.84;R=4.90;rawP=8.70e-05;adjP=0.0111"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA2"]
["HLA-DQA1"]
["GALC"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","MHC class I protein complex","GO:0042612"]
["C=22;O=3;E=0.10;R=29.95;rawP=0.0001;adjP=0.0128"]
["HLA-C"]
["MICA"]
["HLA-A"]

{"sheet":"S17","index":1,"n_rows":169,"n_cols":3,"rows_kept":169,"cut":false,"hidden":false,"merged":[]}
["S17. HKA KEGG enrichment results - G.g. gorilla balancing selection"]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["KEGG pathway","Allograft rejection",5330]
["C=36;O=9;E=0.20;R=45.09;rawP=3.10e-13;adjP=8.37e-12"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["KEGG pathway","Graft-versus-host disease",5332]
["C=40;O=9;E=0.22;R=40.58;rawP=8.85e-13;adjP=2.39e-11"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["KEGG pathway","Type I diabetes mellitus",4940]
["C=42;O=9;E=0.23;R=38.65;rawP=1.43e-12;adjP=3.86e-11"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["KEGG pathway","Autoimmune thyroid disease",5320]
["C=51;O=9;E=0.28;R=31.83;rawP=9.35e-12;adjP=2.52e-10"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["KEGG pathway","Viral myocarditis",5416]
["C=69;O=9;E=0.38;R=23.52;rawP=1.60e-10;adjP=4.32e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["KEGG pathway","Asthma",5310]
["C=29;O=7;E=0.16;R=43.53;rawP=1.93e-10;adjP=5.21e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["KEGG pathway","Antigen processing and presentation",4612]
["C=74;O=9;E=0.41;R=21.93;rawP=3.05e-10;adjP=8.24e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["KEGG pathway","Intestinal immune network for IgA production",4672]
["C=47;O=7;E=0.26;R=26.86;rawP=7.16e-09;adjP=1.93e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["KEGG pathway","Phagosome",4145]
["C=150;O=10;E=0.83;R=12.02;rawP=1.17e-08;adjP=3.16e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-C"]
["DYNC2H1"]
["HLA-DPB1"]
["HLA-A"]
["KEGG pathway","Staphylococcus aureus infection",5150]
["C=54;O=7;E=0.30;R=23.38;rawP=1.95e-08;adjP=5.26e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["KEGG pathway","Cell adhesion molecules (CAMs)",4514]
["C=132;O=9;E=0.73;R=12.30;rawP=5.35e-08;adjP=1.44e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["KEGG pathway","Leishmaniasis",5140]
["C=71;O=7;E=0.39;R=17.78;rawP=1.36e-07;adjP=3.67e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["KEGG pathway","Rheumatoid arthritis",5323]
["C=90;O=7;E=0.50;R=14.03;rawP=6.98e-07;adjP=1.88e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["KEGG pathway","Toxoplasmosis",5145]
["C=131;O=7;E=0.73;R=9.64;rawP=8.64e-06;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["KEGG pathway","Systemic lupus erythematosus",5322]
["C=135;O=7;E=0.75;R=9.35;rawP=1.05e-05;adjP=0.0003"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["KEGG pathway","Olfactory transduction",4740]
["C=388;O=9;E=2.15;R=4.18;rawP=0.0003;adjP=0.0081"]
["OR10A4"]
["OR10A2"]
["OR2D2"]
["OR51B4"]
["OR10A5"]
["OR52J3"]
["OR52M1"]
["OR51B6"]
["OR4K2"]

{"sheet":"S18","index":2,"n_rows":154,"n_cols":3,"rows_kept":154,"cut":false,"hidden":false,"merged":[]}
["S18. HKA PheWAS enrichment results - G.g. gorilla balancing selection"]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["PheWAS","Type 1 diabetic ketoacidosis","PheWAS:250.11"]
["C=32;O=8;E=0.36;R=22.49;rawP=3.90e-10;adjP=1.35e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["LUZP2"]
["HLA-DQB1"]
["HCG9"]
["HLA-DQB2"]
["PheWAS","Type 1 diabetic neuropathy","PheWAS:250.14"]
["C=54;O=8;E=0.60;R=13.33;rawP=3.39e-08;adjP=1.17e-05"]
["PLEKHM1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["PheWAS","Type 1 diabetes","PheWAS:250.1"]
["C=167;O=11;E=1.86;R=5.92;rawP=2.14e-07;adjP=7.40e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQB1"]
["HCG9"]
["HLA-DQB2"]
["PLEKHM1"]
["HLA-C"]
["LUZP2"]
["HLA-DPB1"]
["PheWAS","Discoid lupus erythematosus","PheWAS:695.4"]
["C=85;O=8;E=0.94;R=8.47;rawP=1.30e-06;adjP=0.0004"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQB2"]
["MICA"]
["ZNRD1-AS1"]
["HLA-DPB1"]
["HLA-A"]
["PheWAS","Lupus erythematosus","PheWAS:695.41"]
["C=45;O=6;E=0.50;R=11.99;rawP=4.98e-06;adjP=0.0017"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["HLA-A"]
["PheWAS","Erythematous conditions","PheWAS:695"]
["C=279;O=12;E=3.10;R=3.87;rawP=4.93e-06;adjP=0.0017"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HCP5"]
["HLA-DQB1"]
["HCG9"]
["HLA-DQB2"]
["MICA"]
["LUZP2"]
["ZNRD1-AS1"]
["HLA-DPB1"]
["HLA-A"]
["PheWAS","Rheumatoid arthritis","PheWAS:714.1"]
["C=53;O=6;E=0.59;R=10.18;rawP=1.33e-05;adjP=0.0046"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["LUZP2"]
["HLA-DQB1"]
["HCG9"]
["PheWAS","Diseases of the larynx and vocal cords","PheWAS:473"]
["C=93;O=7;E=1.03;R=6.77;rawP=3.33e-05;adjP=0.0115"]
["C1orf63"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-C"]
["HCP5"]
["HLA-DQB1"]
["PheWAS","Type 1 diabetes nephropathy","PheWAS:250.12"]
["C=38;O=5;E=0.42;R=11.84;rawP=3.85e-05;adjP=0.0133"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQB2"]
["PheWAS","Psoriasis","PheWAS:696.4"]
["C=97;O=7;E=1.08;R=6.49;rawP=4.40e-05;adjP=0.0152"]
["PLEKHM1"]
["HLA-C"]
["HCP5"]
["HLA-DQB1"]
["HCG9"]
["ADCY8"]
["MICA"]
["PheWAS","Rheumatoid arthritis & related inflammatory polyarthropathies","PheWAS:714"]
["C=66;O=6;E=0.73;R=8.18;rawP=4.83e-05;adjP=0.0167"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["LUZP2"]
["HLA-DQB1"]
["HCG9"]
["PheWAS","Rosacea","PheWAS:695.3"]
["C=41;O=5;E=0.46;R=10.97;rawP=5.63e-05;adjP=0.0195"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HCP5"]
["HLA-DQB1"]
["PheWAS","Type 1 diabetic retinopathy","PheWAS:250.13"]
["C=46;O=5;E=0.51;R=9.78;rawP=9.94e-05;adjP=0.0344"]
["PLEKHM1"]
["HLA-DRA"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQB2"]
["PheWAS","Benign neoplasm of colon","PheWAS:208"]
["C=50;O=5;E=0.56;R=8.99;rawP=0.0001;adjP=0.0346"]
["PLEKHM1"]
["HLA-DRB1"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQB2"]
["PheWAS","Multiple sclerosis","PheWAS:335"]
["C=47;O=5;E=0.52;R=9.57;rawP=0.0001;adjP=0.0346"]
["HLA-DRB1"]
["HLA-DQA2"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQB2"]
["PheWAS","Celiac or tropical sprue","PheWAS:557.1"]
["C=50;O=5;E=0.56;R=8.99;rawP=0.0001;adjP=0.0346"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-A"]
["PheWAS","Systemic lupus erythematosus","PheWAS:695.42"]
["C=49;O=5;E=0.54;R=9.18;rawP=0.0001;adjP=0.0346"]
["HLA-DRA"]
["HLA-DQA2"]
["ZNRD1-AS1"]
["HLA-DQB1"]
["HLA-DQB2"]

{"sheet":"S19","index":3,"n_rows":1074,"n_cols":3,"rows_kept":1074,"cut":false,"hidden":false,"merged":[]}
["S19. HKA GO enrichment results - H. sapiens balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["biological process","interferon-gamma-mediated signaling pathway","GO:0060333"]
["C=74;O=12;E=0.25;R=48.70;rawP=7.92e-18;adjP=3.23e-15"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","cellular response to interferon-gamma","GO:0071346"]
["C=89;O=12;E=0.30;R=40.49;rawP=8.27e-17;adjP=3.37e-14"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","response to interferon-gamma","GO:0034341"]
["C=108;O=12;E=0.36;R=33.37;rawP=9.30e-16;adjP=3.79e-13"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","exogen","GO:0042638"]
["C=178;O=13;E=0.59;R=21.93;rawP=1.32e-14;adjP=5.39e-12"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["CYP2C19"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","hair follicle maturation","GO:0048820"]
["C=192;O=13;E=0.64;R=20.33;rawP=3.54e-14;adjP=1.44e-11"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["CYP2C19"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","antigen processing and presentation","GO:0019882"]
["C=215;O=13;E=0.72;R=18.16;rawP=1.53e-13;adjP=6.24e-11"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["MICA"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","anatomical structure maturation","GO:0071695"]
["C=217;O=13;E=0.72;R=17.99;rawP=1.72e-13;adjP=7.02e-11"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["CYP2C19"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of exogenous peptide antigen","GO:0002478"]
["C=167;O=12;E=0.56;R=21.58;rawP=1.91e-13;adjP=7.79e-11"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of exogenous antigen","GO:0019884"]
["C=169;O=12;E=0.56;R=21.32;rawP=2.20e-13;adjP=8.98e-11"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of peptide antigen","GO:0048002"]
["C=185;O=12;E=0.62;R=19.48;rawP=6.50e-13;adjP=2.65e-10"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","hair cycle process","GO:0022405"]
["C=256;O=13;E=0.85;R=15.25;rawP=1.43e-12;adjP=5.83e-10"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["CYP2C19"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","hair follicle development","GO:0001942"]
["C=256;O=13;E=0.85;R=15.25;rawP=1.43e-12;adjP=5.83e-10"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["CYP2C19"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","molting cycle process","GO:0022404"]
["C=256;O=13;E=0.85;R=15.25;rawP=1.43e-12;adjP=5.83e-10"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["CYP2C19"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","molting cycle","GO:0042303"]
["C=262;O=13;E=0.87;R=14.90;rawP=1.92e-12;adjP=7.83e-10"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["CYP2C19"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","hair cycle","GO:0042633"]
["C=262;O=13;E=0.87;R=14.90;rawP=1.92e-12;adjP=7.83e-10"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["CYP2C19"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","epidermis development","GO:0008544"]
["C=454;O=15;E=1.51;R=9.92;rawP=9.97e-12;adjP=4.07e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["CDSN"]
["HLA-DQB2"]
["CYP2C19"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["KRTAP5-9"]
["HLA-DPB1"]
["biological process","immune response-regulating cell surface receptor signaling pathway","GO:0002768"]
["C=137;O=10;E=0.46;R=21.92;rawP=2.08e-11;adjP=8.49e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["MICA"]
["HLA-DQB2"]
["HLA-G"]
["HLA-DPB1"]
["biological process","T cell costimulation","GO:0031295"]
["C=67;O=8;E=0.22;R=35.86;rawP=4.61e-11;adjP=1.88e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","lymphocyte costimulation","GO:0031294"]
["C=68;O=8;E=0.23;R=35.33;rawP=5.21e-11;adjP=2.13e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","developmental maturation","GO:0021700"]
["C=349;O=13;E=1.16;R=11.19;rawP=7.06e-11;adjP=2.88e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["CYP2C19"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","immune response-activating cell surface receptor signaling pathway","GO:0002429"]
["C=126;O=9;E=0.42;R=21.45;rawP=2.81e-10;adjP=1.15e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["MICA"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of exogenous peptide antigen via MHC class II","GO:0019886"]
["C=91;O=8;E=0.30;R=26.40;rawP=5.66e-10;adjP=2.31e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","T cell receptor signaling pathway","GO:0050852"]
["C=93;O=8;E=0.31;R=25.83;rawP=6.75e-10;adjP=2.75e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of peptide antigen via MHC class II","GO:0002495"]
["C=94;O=8;E=0.31;R=25.56;rawP=7.36e-10;adjP=3.00e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","cytokine-mediated signaling pathway","GO:0019221"]
["C=338;O=12;E=1.13;R=10.66;rawP=7.43e-10;adjP=3.03e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","innate immune response","GO:0045087"]
["C=516;O=14;E=1.72;R=8.15;rawP=7.50e-10;adjP=3.06e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["MICA"]
["HLA-DQB2"]
["HLA-F"]
["POLR3E"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of peptide or polysaccharide antigen via MHC class II","GO:0002504"]
["C=95;O=8;E=0.32;R=25.29;rawP=8.01e-10;adjP=3.27e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","regulation of immune response","GO:0050776"]
["C=528;O=14;E=1.76;R=7.96;rawP=1.01e-09;adjP=4.12e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["CRHR1"]
["HLA-DQA1"]
["HLA-DQB1"]
["MICA"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","positive regulation of T cell activation","GO:0050870"]
["C=165;O=9;E=0.55;R=16.38;rawP=3.10e-09;adjP=1.26e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-G"]
["HLA-DPB1"]
["biological process","positive regulation of leukocyte activation","GO:0002696"]
["C=228;O=10;E=0.76;R=13.17;rawP=3.11e-09;adjP=1.27e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["CRHR1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-G"]
["HLA-DPB1"]
["biological process","antigen receptor-mediated signaling pathway","GO:0050851"]
["C=117;O=8;E=0.39;R=20.53;rawP=4.26e-09;adjP=1.74e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","positive regulation of cell activation","GO:0050867"]
["C=236;O=10;E=0.79;R=12.73;rawP=4.34e-09;adjP=1.77e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["CRHR1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-G"]
["HLA-DPB1"]
["biological process","immune response-regulating signaling pathway","GO:0002764"]
["C=242;O=10;E=0.81;R=12.41;rawP=5.52e-09;adjP=2.25e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["MICA"]
["HLA-DQB2"]
["HLA-G"]
["HLA-DPB1"]
["biological process","cellular response to cytokine stimulus","GO:0071345"]
["C=410;O=12;E=1.37;R=8.79;rawP=6.59e-09;adjP=2.69e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent","GO:0002480"]
["C=9;O=4;E=0.03;R=133.47;rawP=1.35e-08;adjP=5.51e-06"]
["HLA-G"]
["HLA-B"]
["HLA-C"]
["HLA-F"]
["biological process","positive regulation of lymphocyte activation","GO:0051251"]
["C=209;O=9;E=0.70;R=12.93;rawP=2.45e-08;adjP=1.00e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-G"]
["HLA-DPB1"]
["biological process","regulation of T cell activation","GO:0050863"]
["C=219;O=9;E=0.73;R=12.34;rawP=3.67e-08;adjP=1.50e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-G"]
["HLA-DPB1"]
["biological process","immune response-activating signal transduction","GO:0002757"]
["C=229;O=9;E=0.76;R=11.80;rawP=5.39e-08;adjP=2.20e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["MICA"]
["HLA-DQB2"]
["HLA-DPB1"]
["biological process","tissue development","GO:0009888"]
["C=1445;O=19;E=4.81;R=3.95;rawP=6.24e-08;adjP=2.55e-05"]
["HLA-DRA"]
["HLA-DQA2"]
["CRHR1"]
["HLA-DQA1"]
["CDSN"]
["BCL9"]
["HLA-F"]
["HLA-DPB1"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQB2"]
["CYP2C19"]
["HLA-G"]
["GDF2"]
["HLA-C"]
["MINPP1"]
["KRTAP5-9"]
["biological process","response to cytokine stimulus","GO:0034097"]
["C=505;O=12;E=1.68;R=7.14;rawP=6.62e-08;adjP=2.70e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["molecular function",null,"GO:0032395"]
["C=11;O=7;E=0.03;R=207.39;rawP=5.19e-16;adjP=4.46e-14"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["molecular function","MHC class I receptor activity","GO:0032393"]
["C=19;O=4;E=0.06;R=68.61;rawP=2.91e-07;adjP=2.50e-05"]
["HLA-G"]
["HLA-B"]
["HLA-C"]
["HLA-F"]
["cellular component","integral to lumenal side of endoplasmic reticulum membrane","GO:0071556"]
["C=27;O=13;E=0.10;R=131.74;rawP=1.02e-25;adjP=1.21e-23"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["SPPL2C"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","MHC protein complex","GO:0042611"]
["C=37;O=13;E=0.14;R=96.14;rawP=1.76e-23;adjP=2.09e-21"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["MICA"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","ER to Golgi transport vesicle membrane","GO:0012507"]
["C=36;O=12;E=0.13;R=91.21;rawP=2.10e-21;adjP=2.50e-19"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","ER to Golgi transport vesicle","GO:0030134"]
["C=40;O=12;E=0.15;R=82.09;rawP=9.28e-21;adjP=1.10e-18"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","endocytic vesicle membrane","GO:0030666"]
["C=92;O=13;E=0.34;R=38.66;rawP=9.51e-18;adjP=1.13e-15"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["ATP6V0E2"]
["cellular component","transport vesicle membrane","GO:0030658"]
["C=75;O=12;E=0.27;R=43.78;rawP=3.94e-17;adjP=4.69e-15"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","integral to endoplasmic reticulum membrane","GO:0030176"]
["C=105;O=13;E=0.38;R=33.88;rawP=5.74e-17;adjP=6.83e-15"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["SPPL2C"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","MHC class II protein complex","GO:0042613"]
["C=15;O=8;E=0.05;R=145.93;rawP=1.25e-16;adjP=1.49e-14"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","endocytic vesicle","GO:0030139"]
["C=148;O=14;E=0.54;R=25.88;rawP=1.56e-16;adjP=1.86e-14"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["ATP6V0E2"]
["ANXA11"]
["cellular component","intrinsic to endoplasmic reticulum membrane","GO:0031227"]
["C=122;O=13;E=0.45;R=29.16;rawP=4.32e-16;adjP=5.14e-14"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["SPPL2C"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","trans-Golgi network membrane","GO:0032588"]
["C=30;O=8;E=0.11;R=72.97;rawP=1.09e-13;adjP=1.30e-11"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","transport vesicle","GO:0030133"]
["C=144;O=12;E=0.53;R=22.80;rawP=1.30e-13;adjP=1.55e-11"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","clathrin-coated endocytic vesicle membrane","GO:0030669"]
["C=32;O=8;E=0.12;R=68.41;rawP=1.94e-13;adjP=2.31e-11"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","coated vesicle membrane","GO:0030662"]
["C=149;O=12;E=0.54;R=22.04;rawP=1.96e-13;adjP=2.33e-11"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","integral to organelle membrane","GO:0031301"]
["C=205;O=13;E=0.75;R=17.35;rawP=3.86e-13;adjP=4.59e-11"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["SPPL2C"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","clathrin-coated endocytic vesicle","GO:0045334"]
["C=37;O=8;E=0.14;R=59.16;rawP=7.02e-13;adjP=8.35e-11"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","intrinsic to organelle membrane","GO:0031300"]
["C=227;O=13;E=0.83;R=15.67;rawP=1.42e-12;adjP=1.69e-10"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["SPPL2C"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","endosome membrane","GO:0010008"]
["C=311;O=13;E=1.14;R=11.44;rawP=7.48e-11;adjP=8.90e-09"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["ATP6V0E2"]
["cellular component","endosome","GO:0005768"]
["C=556;O=16;E=2.03;R=7.87;rawP=9.40e-11;adjP=1.12e-08"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["CRHR1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["NIPA2"]
["HLA-C"]
["HLA-DPB1"]
["ATP6V0E2"]
["NIPA1"]
["cellular component","coated vesicle","GO:0030135"]
["C=253;O=12;E=0.92;R=12.98;rawP=1.02e-10;adjP=1.21e-08"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","endosomal part","GO:0044440"]
["C=320;O=13;E=1.17;R=11.12;rawP=1.07e-10;adjP=1.27e-08"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["ATP6V0E2"]
["cellular component","cytoplasmic vesicle membrane","GO:0030659"]
["C=340;O=13;E=1.24;R=10.46;rawP=2.25e-10;adjP=2.68e-08"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["ATP6V0E2"]
["cellular component","vesicle membrane","GO:0012506"]
["C=353;O=13;E=1.29;R=10.08;rawP=3.57e-10;adjP=4.25e-08"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["ATP6V0E2"]
["cellular component","trans-Golgi network","GO:0005802"]
["C=126;O=9;E=0.46;R=19.54;rawP=7.43e-10;adjP=8.84e-08"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-DQA2"]
["CRHR1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","cytoplasmic vesicle part","GO:0044433"]
["C=398;O=13;E=1.45;R=8.94;rawP=1.54e-09;adjP=1.83e-07"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["ATP6V0E2"]
["cellular component","clathrin-coated vesicle membrane","GO:0030665"]
["C=109;O=8;E=0.40;R=20.08;rawP=5.64e-09;adjP=6.71e-07"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","MHC class I protein complex","GO:0042612"]
["C=22;O=5;E=0.08;R=62.19;rawP=1.38e-08;adjP=1.64e-06"]
["HLA-G"]
["HLA-B"]
["HLA-C"]
["MICA"]
["HLA-F"]
["cellular component","phagocytic vesicle","GO:0045335"]
["C=50;O=6;E=0.18;R=32.83;rawP=2.60e-08;adjP=3.09e-06"]
["HLA-G"]
["HLA-B"]
["HLA-C"]
["ATP6V0E2"]
["HLA-F"]
["ANXA11"]
["cellular component","lysosomal membrane","GO:0005765"]
["C=139;O=8;E=0.51;R=15.75;rawP=3.84e-08;adjP=4.57e-06"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","phagocytic vesicle membrane","GO:0030670"]
["C=32;O=5;E=0.12;R=42.75;rawP=1.03e-07;adjP=1.23e-05"]
["HLA-G"]
["HLA-B"]
["HLA-C"]
["ATP6V0E2"]
["HLA-F"]
["cellular component","vacuole","GO:0005773"]
["C=403;O=11;E=1.47;R=7.47;rawP=2.01e-07;adjP=2.39e-05"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["AKR1B10"]
["HLA-DPB1"]
["ATP6V0E2"]
["ANXA11"]
["cellular component","vacuolar membrane","GO:0005774"]
["C=182;O=8;E=0.67;R=12.03;rawP=3.08e-07;adjP=3.67e-05"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","lysosome","GO:0005764"]
["C=341;O=10;E=1.25;R=8.02;rawP=3.97e-07;adjP=4.72e-05"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["AKR1B10"]
["HLA-DPB1"]
["ANXA11"]
["cellular component","lytic vacuole","GO:0000323"]
["C=341;O=10;E=1.25;R=8.02;rawP=3.97e-07;adjP=4.72e-05"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["AKR1B10"]
["HLA-DPB1"]
["ANXA11"]
["cellular component","endoplasmic reticulum membrane","GO:0005789"]
["C=765;O=14;E=2.80;R=5.01;rawP=4.85e-07;adjP=5.77e-05"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["CYP2C19"]
["HLA-F"]
["SPPL2C"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","Golgi membrane","GO:0000139"]
["C=547;O=12;E=2.00;R=6.00;rawP=5.48e-07;adjP=6.52e-05"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","nuclear outer membrane-endoplasmic reticulum membrane network","GO:0042175"]
["C=782;O=14;E=2.86;R=4.90;rawP=6.32e-07;adjP=7.52e-05"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["CYP2C19"]
["HLA-F"]
["SPPL2C"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","endoplasmic reticulum part","GO:0044432"]
["C=912;O=15;E=3.33;R=4.50;rawP=6.82e-07;adjP=8.12e-05"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["CYP2C19"]
["HLA-F"]
["SPPL2C"]
["HLA-G"]
["HLA-C"]
["MINPP1"]
["HLA-DPB1"]
["cellular component","clathrin-coated vesicle","GO:0030136"]
["C=206;O=8;E=0.75;R=10.63;rawP=7.90e-07;adjP=9.40e-05"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-DPB1"]
["cellular component","vesicle","GO:0031982"]
["C=963;O=15;E=3.52;R=4.26;rawP=1.35e-06;adjP=0.0002"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["CRHR1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["ATP6V0E2"]
["ANXA11"]

{"sheet":"S20","index":4,"n_rows":175,"n_cols":3,"rows_kept":175,"cut":false,"hidden":false,"merged":[]}
["S20. HKA KEGG enrichment results - H.sapiens balancing selection"]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["KEGG pathway","Allograft rejection",5330]
["C=36;O=11;E=0.21;R=52.67;rawP=8.80e-17;adjP=2.02e-15"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Graft-versus-host disease",5332]
["C=40;O=11;E=0.23;R=47.41;rawP=3.32e-16;adjP=7.64e-15"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Type I diabetes mellitus",4940]
["C=42;O=11;E=0.24;R=45.15;rawP=6.09e-16;adjP=1.40e-14"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Autoimmune thyroid disease",5320]
["C=51;O=11;E=0.30;R=37.18;rawP=6.48e-15;adjP=1.49e-13"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Viral myocarditis",5416]
["C=69;O=11;E=0.40;R=27.48;rawP=2.27e-13;adjP=5.22e-12"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Antigen processing and presentation",4612]
["C=74;O=11;E=0.43;R=25.63;rawP=5.08e-13;adjP=1.17e-11"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Phagosome",4145]
["C=150;O=12;E=0.87;R=13.79;rawP=7.75e-11;adjP=1.78e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["KEGG pathway","Asthma",5310]
["C=29;O=7;E=0.17;R=41.61;rawP=2.65e-10;adjP=6.10e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Cell adhesion molecules (CAMs)",4514]
["C=132;O=11;E=0.77;R=14.37;rawP=3.17e-10;adjP=7.29e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Intestinal immune network for IgA production",4672]
["C=47;O=7;E=0.27;R=25.68;rawP=9.81e-09;adjP=2.26e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Staphylococcus aureus infection",5150]
["C=54;O=7;E=0.31;R=22.35;rawP=2.67e-08;adjP=6.14e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Rheumatoid arthritis",5323]
["C=90;O=8;E=0.52;R=15.32;rawP=5.41e-08;adjP=1.24e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["ATP6V0E2"]
["KEGG pathway","Leishmaniasis",5140]
["C=71;O=7;E=0.41;R=17.00;rawP=1.85e-07;adjP=4.25e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Systemic lupus erythematosus",5322]
["C=135;O=7;E=0.78;R=8.94;rawP=1.41e-05;adjP=0.0003"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Toxoplasmosis",5145]
["C=131;O=7;E=0.76;R=9.21;rawP=1.16e-05;adjP=0.0003"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]

{"sheet":"S21","index":5,"n_rows":342,"n_cols":3,"rows_kept":342,"cut":false,"hidden":false,"merged":[]}
["S21. HKA PheWAS enrichment results - H.sapiens balancing selection"]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["PheWAS","Discoid lupus erythematosus","PheWAS:695.4"]
["C=85;O=13;E=1.24;R=10.46;rawP=1.46e-11;adjP=7.10e-09"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQB2"]
["MICA"]
["HLA-F"]
["C6orf10"]
["HLA-DPB2"]
["ZNRD1-AS1"]
["ZNRD1"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Lupus erythematosus","PheWAS:695.41"]
["C=45;O=10;E=0.66;R=15.19;rawP=1.38e-10;adjP=6.71e-08"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQB2"]
["C6orf10"]
["HLA-DPB2"]
["ZNRD1"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Type 1 diabetic ketoacidosis","PheWAS:250.11"]
["C=32;O=9;E=0.47;R=19.23;rawP=1.40e-10;adjP=6.80e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQB2"]
["C6orf10"]
["HLA-F-AS1"]
["BTNL2"]
["PheWAS","Type 1 diabetic neuropathy","PheWAS:250.14"]
["C=54;O=10;E=0.79;R=12.66;rawP=9.58e-10;adjP=4.66e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["CRHR1"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQB2"]
["C6orf10"]
["HLA-C"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Psoriasis vulgaris","PheWAS:696.41"]
["C=60;O=10;E=0.88;R=11.39;rawP=2.87e-09;adjP=1.39e-06"]
["HLA-B"]
["CRHR1"]
["HCP5"]
["HLA-DQB1"]
["MICA"]
["C6orf15"]
["HLA-C"]
["MINPP1"]
["MAPT"]
["PSORS1C1"]
["PheWAS","Type 1 diabetes","PheWAS:250.1"]
["C=167;O=14;E=2.44;R=5.73;rawP=7.38e-09;adjP=3.59e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["CRHR1"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQB2"]
["C6orf10"]
["HLA-F-AS1"]
["HLA-C"]
["ZNRD1"]
["HLA-DPB1"]
["MAPT"]
["BTNL2"]
["PheWAS","Erythematous conditions","PheWAS:695"]
["C=279;O=17;E=4.08;R=4.17;rawP=8.36e-09;adjP=4.06e-06"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-F"]
["C6orf10"]
["HLA-DPB1"]
["HLA-DRB1"]
["HLA-B"]
["HCP5"]
["HLA-DQB1"]
["MICA"]
["HLA-DQB2"]
["HLA-DPB2"]
["HLA-F-AS1"]
["ZNRD1"]
["ZNRD1-AS1"]
["PSORS1C1"]
["BTNL2"]
["PheWAS","Systemic lupus erythematosus","PheWAS:695.42"]
["C=49;O=9;E=0.72;R=12.56;rawP=8.87e-09;adjP=4.31e-06"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQB2"]
["HLA-F"]
["ZNRD1"]
["ZNRD1-AS1"]
["BTNL2"]
["PheWAS","Celiac or tropical sprue","PheWAS:557.1"]
["C=50;O=9;E=0.73;R=12.30;rawP=1.07e-08;adjP=5.20e-06"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQB1"]
["C6orf10"]
["ZNRD1"]
["HLA-DPB1"]
["PSORS1C1"]
["BTNL2"]
["PheWAS","Bullous dermatoses","PheWAS:695.2"]
["C=37;O=8;E=0.54;R=14.78;rawP=1.81e-08;adjP=8.80e-06"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-F-AS1"]
["ZNRD1-AS1"]
["ZNRD1"]
["HLA-DQB1"]
["C6orf10"]
["PSORS1C1"]
["PheWAS","Type 1 diabetes nephropathy","PheWAS:250.12"]
["C=38;O=8;E=0.56;R=14.39;rawP=2.28e-08;adjP=1.11e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["ZNRD1"]
["HLA-DQB1"]
["HLA-DQB2"]
["C6orf10"]
["BTNL2"]
["PheWAS","Psoriasis","PheWAS:696.4"]
["C=97;O=11;E=1.42;R=7.75;rawP=2.58e-08;adjP=1.25e-05"]
["HLA-B"]
["CRHR1"]
["HCP5"]
["HLA-DQB1"]
["MICA"]
["C6orf10"]
["C6orf15"]
["HLA-C"]
["MINPP1"]
["MAPT"]
["PSORS1C1"]
["PheWAS","Celiac disease","PheWAS:557.11"]
["C=40;O=8;E=0.59;R=13.67;rawP=3.51e-08;adjP=1.71e-05"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["ZNRD1"]
["HLA-DQB1"]
["HLA-DPB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Retinoschisis and retinal cysts","PheWAS:361.2"]
["C=39;O=7;E=0.57;R=12.27;rawP=6.57e-07;adjP=0.0003"]
["HLA-DRA"]
["HLA-B"]
["ZNRD1"]
["HLA-DQB1"]
["HLA-DQB2"]
["BTNL2"]
["PSORS1C1"]
["PheWAS","Psoriasis & related disorders","PheWAS:696"]
["C=129;O=11;E=1.89;R=5.83;rawP=5.35e-07;adjP=0.0003"]
["HLA-B"]
["CRHR1"]
["HCP5"]
["HLA-DQB1"]
["MICA"]
["C6orf10"]
["C6orf15"]
["HLA-C"]
["MINPP1"]
["MAPT"]
["PSORS1C1"]
["PheWAS","Rosacea","PheWAS:695.3"]
["C=41;O=7;E=0.60;R=11.67;rawP=9.42e-07;adjP=0.0005"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HCP5"]
["HLA-DQB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Type 1 diabetic retinopathy","PheWAS:250.13"]
["C=46;O=7;E=0.67;R=10.40;rawP=2.14e-06;adjP=0.0010"]
["HLA-DRA"]
["CRHR1"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQB2"]
["MAPT"]
["BTNL2"]
["PheWAS","Multiple sclerosis","PheWAS:335"]
["C=47;O=7;E=0.69;R=10.18;rawP=2.49e-06;adjP=0.0012"]
["HLA-DRB1"]
["HLA-B"]
["HLA-DQA2"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQB2"]
["C6orf10"]
["PheWAS","Shock","PheWAS:797"]
["C=32;O=6;E=0.47;R=12.82;rawP=3.64e-06;adjP=0.0018"]
["HLA-DRB1"]
["HLA-DQA2"]
["HLA-DQB1"]
["C6orf10"]
["MAPT"]
["BTNL2"]
["PheWAS","Retinal detachments and defects","PheWAS:361"]
["C=88;O=8;E=1.29;R=6.21;rawP=1.90e-05;adjP=0.0092"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQB2"]
["MINPP1"]
["ZNRD1"]
["PSORS1C1"]
["BTNL2"]
["PheWAS","Vaginitis and vulvovaginitis","PheWAS:614.52"]
["C=28;O=5;E=0.41;R=12.21;rawP=3.45e-05;adjP=0.0168"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-C"]
["HLA-DQB1"]
["BTNL2"]
["PheWAS","Diabetes mellitus","PheWAS:250"]
["C=425;O=16;E=6.22;R=2.57;rawP=3.48e-05;adjP=0.0169"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["CRHR1"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQB2"]
["MICA"]
["C6orf10"]
["HLA-DPB2"]
["HLA-F-AS1"]
["HLA-C"]
["ZNRD1"]
["HLA-DPB1"]
["MAPT"]
["BTNL2"]
["PheWAS","Intestinal malabsorption","PheWAS:557"]
["C=130;O=9;E=1.90;R=4.73;rawP=4.66e-05;adjP=0.0226"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQB1"]
["C6orf10"]
["ZNRD1"]
["HLA-DPB1"]
["PSORS1C1"]
["BTNL2"]
["PheWAS","Benign neoplasm of colon","PheWAS:208"]
["C=50;O=6;E=0.73;R=8.20;rawP=5.36e-05;adjP=0.0260"]
["HLA-DRB1"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQB2"]
["CYP2C19"]
["C6orf10"]
["PheWAS","Eosinophilia","PheWAS:288.3"]
["C=32;O=5;E=0.47;R=10.68;rawP=6.79e-05;adjP=0.0330"]
["HLA-F-AS1"]
["HLA-DQA2"]
["HLA-DQB1"]
["HLA-DQB2"]
["BTNL2"]
["PheWAS","Rheumatoid arthritis","PheWAS:714.1"]
["C=53;O=6;E=0.78;R=7.74;rawP=7.52e-05;adjP=0.0365"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA2"]
["HLA-DQB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Hematuria","PheWAS:593"]
["C=108;O=8;E=1.58;R=5.06;rawP=8.62e-05;adjP=0.0419"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA2"]
["HLA-DQB1"]
["C6orf10"]
["HLA-F-AS1"]
["ZNRD1"]
["PheWAS","Infection of the eye","PheWAS:369"]
["C=112;O=8;E=1.64;R=4.88;rawP=0.0001;adjP=0.0486"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-F-AS1"]
["CRHR1"]
["HLA-DQB1"]
["C6orf10"]
["MAPT"]
["BTNL2"]
["PheWAS","Hallux rigidus","PheWAS:735.23"]
["C=36;O=5;E=0.53;R=9.49;rawP=0.0001;adjP=0.0486"]
["HLA-B"]
["CRHR1"]
["HLA-DQB2"]
["C6orf10"]
["MAPT"]
["PheWAS","Conjunctivitis, infectious","PheWAS:369.5"]
["C=37;O=5;E=0.54;R=9.24;rawP=0.0001;adjP=0.0486"]
["HLA-DRB1"]
["CRHR1"]
["HLA-DQB1"]
["C6orf10"]
["MAPT"]
["PheWAS","Ectropion or entropion","PheWAS:374.1"]
["C=36;O=5;E=0.53;R=9.49;rawP=0.0001;adjP=0.0486"]
["HLA-DRA"]
["CRHR1"]
["MAPT"]
["BTNL2"]
["PSORS1C1"]
["PheWAS","Adverse effects of cardiac rhythm regulators","PheWAS:972.1"]
["C=36;O=5;E=0.53;R=9.49;rawP=0.0001;adjP=0.0486"]
["HLA-DRB1"]
["HLA-C"]
["CYP2C19"]
["C6orf10"]
["PSORS1C1"]

{"sheet":"S22","index":6,"n_rows":1000,"n_cols":3,"rows_kept":1000,"cut":false,"hidden":false,"merged":[]}
["S22. HKA GO enrichment results - P. paniscus balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["biological process","interferon-gamma-mediated signaling pathway","GO:0060333"]
["C=74;O=9;E=0.28;R=32.47;rawP=6.62e-12;adjP=3.17e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","cellular response to interferon-gamma","GO:0071346"]
["C=89;O=9;E=0.33;R=26.99;rawP=3.65e-11;adjP=1.75e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","response to interferon-gamma","GO:0034341"]
["C=108;O=9;E=0.40;R=22.25;rawP=2.13e-10;adjP=1.02e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","antigen processing and presentation of exogenous peptide antigen","GO:0002478"]
["C=167;O=9;E=0.63;R=14.39;rawP=1.03e-08;adjP=4.93e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","antigen processing and presentation of exogenous antigen","GO:0019884"]
["C=169;O=9;E=0.63;R=14.22;rawP=1.14e-08;adjP=5.46e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","exogen","GO:0042638"]
["C=178;O=9;E=0.67;R=13.50;rawP=1.80e-08;adjP=8.62e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","antigen processing and presentation of peptide antigen","GO:0048002"]
["C=185;O=9;E=0.69;R=12.99;rawP=2.51e-08;adjP=1.20e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","hair follicle maturation","GO:0048820"]
["C=192;O=9;E=0.72;R=12.51;rawP=3.47e-08;adjP=1.66e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","antigen processing and presentation","GO:0019882"]
["C=215;O=9;E=0.81;R=11.17;rawP=9.18e-08;adjP=4.40e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","anatomical structure maturation","GO:0071695"]
["C=217;O=9;E=0.81;R=11.07;rawP=9.94e-08;adjP=4.76e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","T cell costimulation","GO:0031295"]
["C=67;O=6;E=0.25;R=23.91;rawP=1.74e-07;adjP=8.33e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","lymphocyte costimulation","GO:0031294"]
["C=68;O=6;E=0.25;R=23.55;rawP=1.90e-07;adjP=9.10e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","hair cycle process","GO:0022405"]
["C=256;O=9;E=0.96;R=9.38;rawP=4.04e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","molting cycle","GO:0042303"]
["C=262;O=9;E=0.98;R=9.17;rawP=4.91e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","hair cycle","GO:0042633"]
["C=262;O=9;E=0.98;R=9.17;rawP=4.91e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","cytokine-mediated signaling pathway","GO:0019221"]
["C=338;O=10;E=1.27;R=7.90;rawP=4.21e-07;adjP=0.0002"]
["ZNF675"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","molting cycle process","GO:0022404"]
["C=256;O=9;E=0.96;R=9.38;rawP=4.04e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","hair follicle development","GO:0001942"]
["C=256;O=9;E=0.96;R=9.38;rawP=4.04e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","epidermis development","GO:0008544"]
["C=454;O=11;E=1.70;R=6.47;rawP=7.55e-07;adjP=0.0004"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["CDSN"]
["HLA-F"]
["HLA-C"]
["DDR1"]
["HLA-DPB1"]
["HLA-A"]
["biological process","antigen processing and presentation of exogenous peptide antigen via MHC class II","GO:0019886"]
["C=91;O=6;E=0.34;R=17.60;rawP=1.08e-06;adjP=0.0005"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","T cell receptor signaling pathway","GO:0050852"]
["C=93;O=6;E=0.35;R=17.22;rawP=1.23e-06;adjP=0.0006"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of peptide antigen via MHC class II","GO:0002495"]
["C=94;O=6;E=0.35;R=17.04;rawP=1.31e-06;adjP=0.0006"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of peptide or polysaccharide antigen via MHC class II","GO:0002504"]
["C=95;O=6;E=0.36;R=16.86;rawP=1.40e-06;adjP=0.0007"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","cellular response to cytokine stimulus","GO:0071345"]
["C=410;O=10;E=1.54;R=6.51;rawP=2.43e-06;adjP=0.0012"]
["ZNF675"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent","GO:0002480"]
["C=9;O=3;E=0.03;R=88.98;rawP=4.11e-06;adjP=0.0020"]
["HLA-C"]
["HLA-F"]
["HLA-A"]
["biological process","antigen receptor-mediated signaling pathway","GO:0050851"]
["C=117;O=6;E=0.44;R=13.69;rawP=4.72e-06;adjP=0.0023"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","developmental maturation","GO:0021700"]
["C=349;O=9;E=1.31;R=6.88;rawP=5.24e-06;adjP=0.0025"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","immune response-activating cell surface receptor signaling pathway","GO:0002429"]
["C=126;O=6;E=0.47;R=12.71;rawP=7.25e-06;adjP=0.0035"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","immune response-regulating cell surface receptor signaling pathway","GO:0002768"]
["C=137;O=6;E=0.51;R=11.69;rawP=1.17e-05;adjP=0.0056"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","response to cytokine stimulus","GO:0034097"]
["C=505;O=10;E=1.89;R=5.29;rawP=1.52e-05;adjP=0.0073"]
["ZNF675"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","regulation of T cell activation","GO:0050863"]
["C=219;O=7;E=0.82;R=8.53;rawP=1.64e-05;adjP=0.0079"]
["HLA-DPA1"]
["HLA-DRB1"]
["CAMK4"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","innate immune response","GO:0045087"]
["C=516;O=10;E=1.93;R=5.17;rawP=1.83e-05;adjP=0.0088"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["CARD9"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","immune response-activating signal transduction","GO:0002757"]
["C=229;O=7;E=0.86;R=8.16;rawP=2.19e-05;adjP=0.0105"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["CARD9"]
["biological process","regulation of immune response","GO:0050776"]
["C=528;O=10;E=1.98;R=5.06;rawP=2.24e-05;adjP=0.0107"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["CARD9"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","immune response-regulating signaling pathway","GO:0002764"]
["C=242;O=7;E=0.91;R=7.72;rawP=3.12e-05;adjP=0.0149"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["CARD9"]
["biological process","positive regulation of T cell activation","GO:0050870"]
["C=165;O=6;E=0.62;R=9.71;rawP=3.37e-05;adjP=0.0161"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","regulation of immune system process","GO:0002682"]
["C=836;O=12;E=3.13;R=3.83;rawP=4.79e-05;adjP=0.0229"]
["ZNF675"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["CARD9"]
["HLA-F"]
["CAMK4"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","activation of immune response","GO:0002253"]
["C=278;O=7;E=1.04;R=6.72;rawP=7.51e-05;adjP=0.0360"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["CARD9"]
["biological process","immune response","GO:0006955"]
["C=1035;O=13;E=3.88;R=3.35;rawP=8.68e-05;adjP=0.0416"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["IL16"]
["ADAMDEC1"]
["HLA-DQA1"]
["HLA-DQB1"]
["CARD9"]
["HLA-F"]
["CAMK4"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["biological process","regulation of lymphocyte activation","GO:0051249"]
["C=285;O=7;E=1.07;R=6.56;rawP=8.77e-05;adjP=0.0420"]
["HLA-DPA1"]
["HLA-DRB1"]
["CAMK4"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["molecular function",null,"GO:0032395"]
["C=11;O=5;E=0.04;R=117.48;rawP=3.30e-10;adjP=2.77e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["molecular function","transmembrane signaling receptor activity","GO:0004888"]
["C=1184;O=16;E=4.58;R=3.49;rawP=6.90e-06;adjP=0.0006"]
["OR2M5"]
["OR2M2"]
["HLA-F"]
["GPR179"]
["DDR1"]
["GRM5"]
["HLA-A"]
["OR2M7"]
["NPSR1"]
["ALK"]
["OR2T12"]
["OR5H6"]
["PTPRN2"]
["HLA-C"]
["TSHR"]
["LPHN3"]
["molecular function","signaling receptor activity","GO:0038023"]
["C=1278;O=16;E=4.94;R=3.24;rawP=1.81e-05;adjP=0.0015"]
["OR2M5"]
["OR2M2"]
["HLA-F"]
["GPR179"]
["DDR1"]
["GRM5"]
["HLA-A"]
["OR2M7"]
["NPSR1"]
["ALK"]
["OR2T12"]
["OR5H6"]
["PTPRN2"]
["HLA-C"]
["TSHR"]
["LPHN3"]
["molecular function","receptor activity","GO:0004872"]
["C=1483;O=17;E=5.74;R=2.96;rawP=2.91e-05;adjP=0.0024"]
["OR2M5"]
["OR2M2"]
["HLA-F"]
["GPR179"]
["DDR1"]
["GRM5"]
["HLA-A"]
["OR2M7"]
["NPSR1"]
["ALK"]
["OR2T12"]
["OR5H6"]
["MCC"]
["PTPRN2"]
["HLA-C"]
["TSHR"]
["LPHN3"]
["molecular function","MHC class I receptor activity","GO:0032393"]
["C=19;O=3;E=0.07;R=40.81;rawP=5.10e-05;adjP=0.0043"]
["HLA-C"]
["HLA-F"]
["HLA-A"]
["molecular function","glycine N-acyltransferase activity","GO:0047961"]
["C=4;O=2;E=0.02;R=129.23;rawP=8.78e-05;adjP=0.0074"]
["GLYATL1"]
["GLYATL2"]
["molecular function","molecular transducer activity","GO:0060089"]
["C=1580;O=16;E=6.11;R=2.62;rawP=0.0002;adjP=0.0168"]
["OR2M5"]
["OR2M2"]
["HLA-F"]
["GPR179"]
["DDR1"]
["GRM5"]
["HLA-A"]
["OR2M7"]
["NPSR1"]
["ALK"]
["OR2T12"]
["OR5H6"]
["PTPRN2"]
["HLA-C"]
["TSHR"]
["LPHN3"]
["molecular function","signal transducer activity","GO:0004871"]
["C=1580;O=16;E=6.11;R=2.62;rawP=0.0002;adjP=0.0168"]
["OR2M5"]
["OR2M2"]
["HLA-F"]
["GPR179"]
["DDR1"]
["GRM5"]
["HLA-A"]
["OR2M7"]
["NPSR1"]
["ALK"]
["OR2T12"]
["OR5H6"]
["PTPRN2"]
["HLA-C"]
["TSHR"]
["LPHN3"]
["cellular component","integral to lumenal side of endoplasmic reticulum membrane","GO:0071556"]
["C=27;O=9;E=0.11;R=83.04;rawP=6.85e-16;adjP=8.90e-14"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","transport vesicle membrane","GO:0030658"]
["C=75;O=11;E=0.30;R=36.54;rawP=7.39e-15;adjP=9.61e-13"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["PTPRN2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["SCGN"]
["cellular component","ER to Golgi transport vesicle membrane","GO:0012507"]
["C=36;O=9;E=0.14;R=62.28;rawP=1.34e-14;adjP=1.74e-12"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","MHC protein complex","GO:0042611"]
["C=37;O=9;E=0.15;R=60.60;rawP=1.76e-14;adjP=2.29e-12"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","ER to Golgi transport vesicle","GO:0030134"]
["C=40;O=9;E=0.16;R=56.05;rawP=3.84e-14;adjP=4.99e-12"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","transport vesicle","GO:0030133"]
["C=144;O=11;E=0.58;R=19.03;rawP=1.14e-11;adjP=1.48e-09"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["PTPRN2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["SCGN"]
["cellular component","MHC class II protein complex","GO:0042613"]
["C=15;O=6;E=0.06;R=99.65;rawP=1.62e-11;adjP=2.11e-09"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","endocytic vesicle membrane","GO:0030666"]
["C=92;O=9;E=0.37;R=24.37;rawP=1.04e-10;adjP=1.35e-08"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","integral to endoplasmic reticulum membrane","GO:0030176"]
["C=105;O=9;E=0.42;R=21.35;rawP=3.44e-10;adjP=4.47e-08"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","intrinsic to endoplasmic reticulum membrane","GO:0031227"]
["C=122;O=9;E=0.49;R=18.38;rawP=1.32e-09;adjP=1.72e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","trans-Golgi network membrane","GO:0032588"]
["C=30;O=6;E=0.12;R=49.82;rawP=1.83e-09;adjP=2.38e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","clathrin-coated endocytic vesicle membrane","GO:0030669"]
["C=32;O=6;E=0.13;R=46.71;rawP=2.78e-09;adjP=3.61e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","clathrin-coated endocytic vesicle","GO:0045334"]
["C=37;O=6;E=0.15;R=40.40;rawP=7.02e-09;adjP=9.13e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","endocytic vesicle","GO:0030139"]
["C=148;O=9;E=0.59;R=15.15;rawP=7.32e-09;adjP=9.52e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","coated vesicle membrane","GO:0030662"]
["C=149;O=9;E=0.60;R=15.05;rawP=7.77e-09;adjP=1.01e-06"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","cytoplasmic vesicle membrane","GO:0030659"]
["C=340;O=11;E=1.36;R=8.06;rawP=9.90e-08;adjP=1.29e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["PTPRN2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["SCGN"]
["cellular component","integral to organelle membrane","GO:0031301"]
["C=205;O=9;E=0.82;R=10.94;rawP=1.23e-07;adjP=1.60e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","vesicle membrane","GO:0012506"]
["C=353;O=11;E=1.42;R=7.76;rawP=1.45e-07;adjP=1.89e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["PTPRN2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["SCGN"]
["cellular component","intrinsic to organelle membrane","GO:0031300"]
["C=227;O=9;E=0.91;R=9.88;rawP=2.93e-07;adjP=3.81e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","cytoplasmic vesicle part","GO:0044433"]
["C=398;O=11;E=1.60;R=6.89;rawP=4.79e-07;adjP=6.23e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["PTPRN2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["SCGN"]
["cellular component","coated vesicle","GO:0030135"]
["C=253;O=9;E=1.02;R=8.86;rawP=7.28e-07;adjP=9.46e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","endosome membrane","GO:0010008"]
["C=311;O=9;E=1.25;R=7.21;rawP=3.99e-06;adjP=0.0005"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","clathrin-coated vesicle membrane","GO:0030665"]
["C=109;O=6;E=0.44;R=13.71;rawP=4.88e-06;adjP=0.0006"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","endosomal part","GO:0044440"]
["C=320;O=9;E=1.28;R=7.01;rawP=5.04e-06;adjP=0.0007"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","endoplasmic reticulum membrane","GO:0005789"]
["C=765;O=13;E=3.07;R=4.23;rawP=9.11e-06;adjP=0.0012"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["DST"]
["HLA-DQA1"]
["HLA-DQB1"]
["TRDN"]
["HLA-F"]
["GPSM1"]
["HLA-C"]
["MOXD1"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","nuclear outer membrane-endoplasmic reticulum membrane network","GO:0042175"]
["C=782;O=13;E=3.14;R=4.14;rawP=1.15e-05;adjP=0.0015"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["DST"]
["HLA-DQA1"]
["HLA-DQB1"]
["TRDN"]
["HLA-F"]
["GPSM1"]
["HLA-C"]
["MOXD1"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","trans-Golgi network","GO:0005802"]
["C=126;O=6;E=0.51;R=11.86;rawP=1.12e-05;adjP=0.0015"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","lysosomal membrane","GO:0005765"]
["C=139;O=6;E=0.56;R=10.75;rawP=1.97e-05;adjP=0.0026"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","endoplasmic reticulum part","GO:0044432"]
["C=912;O=13;E=3.66;R=3.55;rawP=5.76e-05;adjP=0.0075"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["DST"]
["HLA-DQA1"]
["HLA-DQB1"]
["TRDN"]
["HLA-F"]
["GPSM1"]
["HLA-C"]
["MOXD1"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","Golgi membrane","GO:0000139"]
["C=547;O=10;E=2.20;R=4.55;rawP=6.08e-05;adjP=0.0079"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["GPSM1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","cell periphery","GO:0071944"]
["C=4281;O=32;E=17.18;R=1.86;rawP=7.73e-05;adjP=0.0100"]
["OR2M5"]
["HLA-DRA"]
["SLCO1A2"]
["OR2M2"]
["HLA-DQA1"]
["TRDN"]
["HLA-F"]
["GPSM1"]
["GPR179"]
["FRK"]
["DDR1"]
["HLA-DPB1"]
["HLA-A"]
["GRM5"]
["OR2M7"]
["ALK"]
["HLA-DRB1"]
["NPSR1"]
["DST"]
["HLA-DPA1"]
["IL16"]
["OR2T12"]
["XKR3"]
["OR5H6"]
["HLA-DQB1"]
["MCC"]
["PTPRN2"]
["MDGA2"]
["HLA-C"]
["TSHR"]
["FABP1"]
["LPHN3"]
["cellular component","vacuolar membrane","GO:0005774"]
["C=182;O=6;E=0.73;R=8.21;rawP=8.90e-05;adjP=0.0116"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","MHC class I protein complex","GO:0042612"]
["C=22;O=3;E=0.09;R=33.97;rawP=9.01e-05;adjP=0.0117"]
["HLA-C"]
["HLA-F"]
["HLA-A"]
["cellular component","plasma membrane","GO:0005886"]
["C=4193;O=31;E=16.83;R=1.84;rawP=0.0001;adjP=0.0130"]
["OR2M5"]
["HLA-DRA"]
["SLCO1A2"]
["OR2M2"]
["HLA-DQA1"]
["TRDN"]
["HLA-F"]
["GPSM1"]
["GPR179"]
["FRK"]
["DDR1"]
["HLA-DPB1"]
["HLA-A"]
["GRM5"]
["OR2M7"]
["ALK"]
["HLA-DRB1"]
["NPSR1"]
["DST"]
["HLA-DPA1"]
["IL16"]
["OR2T12"]
["XKR3"]
["OR5H6"]
["HLA-DQB1"]
["MCC"]
["PTPRN2"]
["MDGA2"]
["HLA-C"]
["TSHR"]
["LPHN3"]
["cellular component","cytoplasmic membrane-bounded vesicle","GO:0016023"]
["C=855;O=12;E=3.43;R=3.50;rawP=0.0001;adjP=0.0130"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["DST"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["PTPRN2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["SCGN"]
["cellular component","clathrin-coated vesicle","GO:0030136"]
["C=206;O=6;E=0.83;R=7.26;rawP=0.0002;adjP=0.0260"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","membrane-bounded vesicle","GO:0031988"]
["C=876;O=12;E=3.52;R=3.41;rawP=0.0002;adjP=0.0260"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["DST"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["PTPRN2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["SCGN"]
["cellular component","phagocytic vesicle membrane","GO:0030670"]
["C=32;O=3;E=0.13;R=23.35;rawP=0.0003;adjP=0.0390"]
["HLA-C"]
["HLA-F"]
["HLA-A"]
["cellular component","Golgi apparatus part","GO:0044431"]
["C=661;O=10;E=2.65;R=3.77;rawP=0.0003;adjP=0.0390"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["GPSM1"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["cellular component","cytoplasmic vesicle","GO:0031410"]
["C=921;O=12;E=3.70;R=3.25;rawP=0.0003;adjP=0.0390"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["DST"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["PTPRN2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["SCGN"]

{"sheet":"S23","index":7,"n_rows":153,"n_cols":3,"rows_kept":153,"cut":false,"hidden":false,"merged":[]}
["S23. HKA KEGG enrichment results - P. paniscus balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["KEGG pathway","Type I diabetes mellitus",4940]
["C=42;O=10;E=0.22;R=44.66;rawP=1.64e-14;adjP=4.10e-13"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["PTPRN2"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["KEGG pathway","Autoimmune thyroid disease",5320]
["C=51;O=10;E=0.27;R=36.78;rawP=1.37e-13;adjP=3.43e-12"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-C"]
["TSHR"]
["HLA-DPB1"]
["HLA-A"]
["KEGG pathway","Allograft rejection",5330]
["C=36;O=9;E=0.19;R=46.89;rawP=2.17e-13;adjP=5.43e-12"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["KEGG pathway","Graft-versus-host disease",5332]
["C=40;O=9;E=0.21;R=42.20;rawP=6.18e-13;adjP=1.54e-11"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["KEGG pathway","Viral myocarditis",5416]
["C=69;O=9;E=0.37;R=24.46;rawP=1.13e-10;adjP=2.83e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["KEGG pathway","Antigen processing and presentation",4612]
["C=74;O=9;E=0.39;R=22.81;rawP=2.15e-10;adjP=5.38e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["KEGG pathway","Asthma",5310]
["C=29;O=6;E=0.15;R=38.81;rawP=8.74e-09;adjP=2.19e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Cell adhesion molecules (CAMs)",4514]
["C=132;O=9;E=0.70;R=12.79;rawP=3.80e-08;adjP=9.50e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["KEGG pathway","Phagosome",4145]
["C=150;O=9;E=0.80;R=11.25;rawP=1.15e-07;adjP=2.88e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["HLA-A"]
["KEGG pathway","Intestinal immune network for IgA production",4672]
["C=47;O=6;E=0.25;R=23.94;rawP=1.83e-07;adjP=4.57e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Staphylococcus aureus infection",5150]
["C=54;O=6;E=0.29;R=20.84;rawP=4.26e-07;adjP=1.07e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Leishmaniasis",5140]
["C=71;O=6;E=0.38;R=15.85;rawP=2.20e-06;adjP=5.50e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Toxoplasmosis",5145]
["C=131;O=7;E=0.70;R=10.02;rawP=6.68e-06;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["PLA2G6"]
["HLA-DPB1"]
["KEGG pathway","Rheumatoid arthritis",5323]
["C=90;O=6;E=0.48;R=12.50;rawP=8.79e-06;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Systemic lupus erythematosus",5322]
["C=135;O=6;E=0.72;R=8.34;rawP=8.73e-05;adjP=0.0022"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]

{"sheet":"S24","index":8,"n_rows":22,"n_cols":3,"rows_kept":22,"cut":false,"hidden":false,"merged":[]}
["S24. HKA PheWAS enrichment results - P. paniscus balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["PheWAS","Type 1 diabetic ketoacidosis","PheWAS:250.11"]
["C=32;O=6;E=0.58;R=10.34;rawP=1.40e-05;adjP=0.0062"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-F-AS1"]
["HLA-DQB1"]
["HCG9"]
["PheWAS","Bullous dermatoses","PheWAS:695.2"]
["C=37;O=6;E=0.67;R=8.94;rawP=3.37e-05;adjP=0.0149"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-F-AS1"]
["ZNRD1-AS1"]
["HLA-DQB1"]
["PSORS1C1"]

{"sheet":"S25","index":9,"n_rows":867,"n_cols":3,"rows_kept":867,"cut":false,"hidden":false,"merged":[]}
["S25. HKA GO enrichment results – P.t. ellioti balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["biological process","interferon-gamma-mediated signaling pathway","GO:0060333"]
["C=74;O=9;E=0.27;R=33.08;rawP=5.54e-12;adjP=2.64e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","cellular response to interferon-gamma","GO:0071346"]
["C=89;O=9;E=0.33;R=27.50;rawP=3.06e-11;adjP=1.46e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","response to interferon-gamma","GO:0034341"]
["C=108;O=9;E=0.40;R=22.67;rawP=1.79e-10;adjP=8.54e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","epidermis development","GO:0008544"]
["C=454;O=14;E=1.67;R=8.39;rawP=6.05e-10;adjP=2.89e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["SPRR2G"]
["HLA-DQA1"]
["HLA-DQB1"]
["SCEL"]
["LCE3E"]
["HLA-G"]
["HLA-C"]
["KRTAP5-9"]
["HLA-DPB1"]
["SPRR2B"]
["biological process","antigen processing and presentation of exogenous peptide antigen","GO:0002478"]
["C=167;O=9;E=0.61;R=14.66;rawP=8.67e-09;adjP=4.14e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of exogenous antigen","GO:0019884"]
["C=169;O=9;E=0.62;R=14.48;rawP=9.62e-09;adjP=4.59e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","exogen","GO:0042638"]
["C=178;O=9;E=0.65;R=13.75;rawP=1.51e-08;adjP=7.20e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of peptide antigen","GO:0048002"]
["C=185;O=9;E=0.68;R=13.23;rawP=2.12e-08;adjP=1.01e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","hair follicle maturation","GO:0048820"]
["C=192;O=9;E=0.71;R=12.75;rawP=2.92e-08;adjP=1.39e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","antigen processing and presentation","GO:0019882"]
["C=215;O=9;E=0.79;R=11.39;rawP=7.75e-08;adjP=3.70e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","anatomical structure maturation","GO:0071695"]
["C=217;O=9;E=0.80;R=11.28;rawP=8.39e-08;adjP=4.00e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","T cell costimulation","GO:0031295"]
["C=67;O=6;E=0.25;R=24.36;rawP=1.55e-07;adjP=7.39e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","lymphocyte costimulation","GO:0031294"]
["C=68;O=6;E=0.25;R=24.00;rawP=1.70e-07;adjP=8.11e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","hair follicle development","GO:0001942"]
["C=256;O=9;E=0.94;R=9.56;rawP=3.42e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","molting cycle","GO:0042303"]
["C=262;O=9;E=0.96;R=9.34;rawP=4.16e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","tissue development","GO:0009888"]
["C=1445;O=19;E=5.31;R=3.58;rawP=3.94e-07;adjP=0.0002"]
["HLA-DRA"]
["CRHR1"]
["HLA-DQA1"]
["SCEL"]
["LCE3E"]
["FBN2"]
["HLA-DPB1"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQB1"]
["SPRR2G"]
["SVIL"]
["HLA-G"]
["GDF2"]
["HLA-C"]
["MINPP1"]
["KRTAP5-9"]
["SPRR2B"]
["biological process","cytokine-mediated signaling pathway","GO:0019221"]
["C=338;O=10;E=1.24;R=8.05;rawP=3.50e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["CCR8"]
["HLA-C"]
["HLA-DPB1"]
["biological process","hair cycle process","GO:0022405"]
["C=256;O=9;E=0.94;R=9.56;rawP=3.42e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","molting cycle process","GO:0022404"]
["C=256;O=9;E=0.94;R=9.56;rawP=3.42e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","hair cycle","GO:0042633"]
["C=262;O=9;E=0.96;R=9.34;rawP=4.16e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","immune response-regulating cell surface receptor signaling pathway","GO:0002768"]
["C=137;O=7;E=0.50;R=13.90;rawP=6.43e-07;adjP=0.0003"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of exogenous peptide antigen via MHC class II","GO:0019886"]
["C=91;O=6;E=0.33;R=17.93;rawP=9.69e-07;adjP=0.0005"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","T cell receptor signaling pathway","GO:0050852"]
["C=93;O=6;E=0.34;R=17.55;rawP=1.10e-06;adjP=0.0005"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of peptide antigen via MHC class II","GO:0002495"]
["C=94;O=6;E=0.35;R=17.36;rawP=1.17e-06;adjP=0.0006"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of peptide or polysaccharide antigen via MHC class II","GO:0002504"]
["C=95;O=6;E=0.35;R=17.18;rawP=1.25e-06;adjP=0.0006"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","positive regulation of leukocyte activation","GO:0002696"]
["C=228;O=8;E=0.84;R=9.54;rawP=1.66e-06;adjP=0.0008"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["CRHR1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-DPB1"]
["biological process","positive regulation of cell activation","GO:0050867"]
["C=236;O=8;E=0.87;R=9.22;rawP=2.15e-06;adjP=0.0010"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["CRHR1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-DPB1"]
["biological process","cellular response to cytokine stimulus","GO:0071345"]
["C=410;O=10;E=1.51;R=6.63;rawP=2.03e-06;adjP=0.0010"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["CCR8"]
["HLA-C"]
["HLA-DPB1"]
["biological process","positive regulation of T cell activation","GO:0050870"]
["C=165;O=7;E=0.61;R=11.54;rawP=2.24e-06;adjP=0.0011"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent","GO:0002480"]
["C=9;O=3;E=0.03;R=90.66;rawP=3.88e-06;adjP=0.0019"]
["HLA-G"]
["HLA-B"]
["HLA-C"]
["biological process","antigen receptor-mediated signaling pathway","GO:0050851"]
["C=117;O=6;E=0.43;R=13.95;rawP=4.23e-06;adjP=0.0020"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","developmental maturation","GO:0021700"]
["C=349;O=9;E=1.28;R=7.01;rawP=4.46e-06;adjP=0.0021"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","immune response-activating cell surface receptor signaling pathway","GO:0002429"]
["C=126;O=6;E=0.46;R=12.95;rawP=6.49e-06;adjP=0.0031"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","positive regulation of lymphocyte activation","GO:0051251"]
["C=209;O=7;E=0.77;R=9.11;rawP=1.07e-05;adjP=0.0051"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","response to cytokine stimulus","GO:0034097"]
["C=505;O=10;E=1.86;R=5.39;rawP=1.28e-05;adjP=0.0061"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["CCR8"]
["HLA-C"]
["HLA-DPB1"]
["biological process","regulation of T cell activation","GO:0050863"]
["C=219;O=7;E=0.81;R=8.69;rawP=1.45e-05;adjP=0.0069"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","immune response","GO:0006955"]
["C=1035;O=14;E=3.81;R=3.68;rawP=1.51e-05;adjP=0.0072"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["CRHR1"]
["HLA-DQA1"]
["HLA-DQB1"]
["POLR3E"]
["HLA-G"]
["CCR8"]
["IGSF6"]
["HLA-C"]
["IGLL1"]
["HLA-DPB1"]
["biological process","innate immune response","GO:0045087"]
["C=516;O=10;E=1.90;R=5.27;rawP=1.54e-05;adjP=0.0073"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["POLR3E"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","regulation of immune response","GO:0050776"]
["C=528;O=10;E=1.94;R=5.15;rawP=1.88e-05;adjP=0.0090"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["CRHR1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["biological process","regulation of leukocyte activation","GO:0002694"]
["C=325;O=8;E=1.19;R=6.69;rawP=2.24e-05;adjP=0.0107"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["CRHR1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-DPB1"]
["molecular function",null,"GO:0032395"]
["C=11;O=5;E=0.04;R=139.06;rawP=1.38e-10;adjP=1.30e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["molecular function","MHC class I receptor activity","GO:0032393"]
["C=19;O=3;E=0.06;R=48.31;rawP=3.07e-05;adjP=0.0029"]
["HLA-G"]
["HLA-B"]
["HLA-C"]
["molecular function","ammonium transmembrane transporter activity","GO:0008519"]
["C=5;O=2;E=0.02;R=122.38;rawP=0.0001;adjP=0.0094"]
["RHCE"]
["RHD"]
["cellular component","integral to lumenal side of endoplasmic reticulum membrane","GO:0071556"]
["C=27;O=10;E=0.11;R=93.66;rawP=3.66e-18;adjP=4.32e-16"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["SPPL2C"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","ER to Golgi transport vesicle membrane","GO:0012507"]
["C=36;O=9;E=0.14;R=63.22;rawP=1.16e-14;adjP=1.37e-12"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","MHC protein complex","GO:0042611"]
["C=37;O=9;E=0.15;R=61.51;rawP=1.53e-14;adjP=1.81e-12"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","ER to Golgi transport vesicle","GO:0030134"]
["C=40;O=9;E=0.16;R=56.90;rawP=3.33e-14;adjP=3.93e-12"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","integral to endoplasmic reticulum membrane","GO:0030176"]
["C=105;O=11;E=0.42;R=26.49;rawP=2.88e-13;adjP=3.40e-11"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["SPPL2C"]
["HLA-G"]
["SAMD8"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","intrinsic to endoplasmic reticulum membrane","GO:0031227"]
["C=122;O=11;E=0.48;R=22.80;rawP=1.54e-12;adjP=1.82e-10"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["SPPL2C"]
["HLA-G"]
["SAMD8"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","endocytic vesicle membrane","GO:0030666"]
["C=92;O=10;E=0.36;R=27.49;rawP=2.57e-12;adjP=3.03e-10"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","endocytic vesicle","GO:0030139"]
["C=148;O=11;E=0.59;R=18.80;rawP=1.29e-11;adjP=1.52e-09"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["ANXA11"]
["cellular component","transport vesicle membrane","GO:0030658"]
["C=75;O=9;E=0.30;R=30.35;rawP=1.37e-11;adjP=1.62e-09"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","MHC class II protein complex","GO:0042613"]
["C=15;O=6;E=0.06;R=101.16;rawP=1.47e-11;adjP=1.73e-09"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","integral to organelle membrane","GO:0031301"]
["C=205;O=11;E=0.81;R=13.57;rawP=4.37e-10;adjP=5.16e-08"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["SPPL2C"]
["HLA-G"]
["SAMD8"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","intrinsic to organelle membrane","GO:0031300"]
["C=227;O=11;E=0.90;R=12.25;rawP=1.29e-09;adjP=1.52e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["SPPL2C"]
["HLA-G"]
["SAMD8"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","trans-Golgi network membrane","GO:0032588"]
["C=30;O=6;E=0.12;R=50.58;rawP=1.67e-09;adjP=1.97e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","clathrin-coated endocytic vesicle membrane","GO:0030669"]
["C=32;O=6;E=0.13;R=47.42;rawP=2.53e-09;adjP=2.99e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","transport vesicle","GO:0030133"]
["C=144;O=9;E=0.57;R=15.81;rawP=5.02e-09;adjP=5.92e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","clathrin-coated endocytic vesicle","GO:0045334"]
["C=37;O=6;E=0.15;R=41.01;rawP=6.40e-09;adjP=7.55e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","coated vesicle membrane","GO:0030662"]
["C=149;O=9;E=0.59;R=15.28;rawP=6.78e-09;adjP=8.00e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","endosome","GO:0005768"]
["C=556;O=13;E=2.20;R=5.91;rawP=2.19e-07;adjP=2.58e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["CRHR1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["NIPA2"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["NIPA1"]
["cellular component","endosome membrane","GO:0010008"]
["C=311;O=10;E=1.23;R=8.13;rawP=3.66e-07;adjP=4.32e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","endosomal part","GO:0044440"]
["C=320;O=10;E=1.27;R=7.90;rawP=4.75e-07;adjP=5.61e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","trans-Golgi network","GO:0005802"]
["C=126;O=7;E=0.50;R=14.05;rawP=6.36e-07;adjP=7.50e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["CRHR1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","coated vesicle","GO:0030135"]
["C=253;O=9;E=1.00;R=9.00;rawP=6.39e-07;adjP=7.54e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","cytoplasmic vesicle membrane","GO:0030659"]
["C=340;O=10;E=1.34;R=7.44;rawP=8.27e-07;adjP=9.76e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","vesicle membrane","GO:0012506"]
["C=353;O=10;E=1.40;R=7.16;rawP=1.16e-06;adjP=0.0001"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","phagocytic vesicle","GO:0045335"]
["C=50;O=5;E=0.20;R=25.29;rawP=1.53e-06;adjP=0.0002"]
["HLA-G"]
["HLA-B"]
["HLA-C"]
["ATP6V0E2"]
["ANXA11"]
["cellular component","cytoplasmic vesicle part","GO:0044433"]
["C=398;O=10;E=1.57;R=6.35;rawP=3.40e-06;adjP=0.0004"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","clathrin-coated vesicle membrane","GO:0030665"]
["C=109;O=6;E=0.43;R=13.92;rawP=4.46e-06;adjP=0.0005"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","phagocytic vesicle membrane","GO:0030670"]
["C=32;O=4;E=0.13;R=31.61;rawP=7.38e-06;adjP=0.0009"]
["HLA-G"]
["HLA-B"]
["HLA-C"]
["ATP6V0E2"]
["cellular component","lysosomal membrane","GO:0005765"]
["C=139;O=6;E=0.55;R=10.92;rawP=1.80e-05;adjP=0.0021"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","vacuolar membrane","GO:0005774"]
["C=182;O=6;E=0.72;R=8.34;rawP=8.17e-05;adjP=0.0096"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","MHC class I protein complex","GO:0042612"]
["C=22;O=3;E=0.09;R=34.49;rawP=8.62e-05;adjP=0.0102"]
["HLA-G"]
["HLA-B"]
["HLA-C"]
["cellular component","cornified envelope","GO:0001533"]
["C=23;O=3;E=0.09;R=32.99;rawP=9.88e-05;adjP=0.0117"]
["SPRR2G"]
["SCEL"]
["SPRR2B"]
["cellular component","nuclear outer membrane-endoplasmic reticulum membrane network","GO:0042175"]
["C=782;O=11;E=3.09;R=3.56;rawP=0.0002;adjP=0.0236"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["SPPL2C"]
["HLA-G"]
["SAMD8"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","clathrin-coated vesicle","GO:0030136"]
["C=206;O=6;E=0.81;R=7.37;rawP=0.0002;adjP=0.0236"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","endoplasmic reticulum part","GO:0044432"]
["C=912;O=12;E=3.61;R=3.33;rawP=0.0002;adjP=0.0236"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["SPPL2C"]
["HLA-G"]
["SAMD8"]
["HLA-C"]
["MINPP1"]
["HLA-DPB1"]
["cellular component","endoplasmic reticulum membrane","GO:0005789"]
["C=765;O=11;E=3.02;R=3.64;rawP=0.0002;adjP=0.0236"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["SPPL2C"]
["HLA-G"]
["SAMD8"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","vacuole","GO:0005773"]
["C=403;O=8;E=1.59;R=5.02;rawP=0.0002;adjP=0.0236"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["ATP6V0E2"]
["HLA-DPB1"]
["ANXA11"]
["cellular component","vesicle","GO:0031982"]
["C=963;O=12;E=3.81;R=3.15;rawP=0.0003;adjP=0.0354"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["CRHR1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["ANXA11"]
["cellular component","Golgi membrane","GO:0000139"]
["C=547;O=9;E=2.16;R=4.16;rawP=0.0003;adjP=0.0354"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","lysosome","GO:0005764"]
["C=341;O=7;E=1.35;R=5.19;rawP=0.0004;adjP=0.0472"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["ANXA11"]

{"sheet":"S26","index":10,"n_rows":152,"n_cols":3,"rows_kept":152,"cut":false,"hidden":false,"merged":[]}
["S26. HKA KEGG enrichment results - P.t. ellioti balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["KEGG pathway","Allograft rejection",5330]
["C=36;O=9;E=0.18;R=49.67;rawP=1.28e-13;adjP=2.82e-12"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Graft-versus-host disease",5332]
["C=40;O=9;E=0.20;R=44.70;rawP=3.65e-13;adjP=8.03e-12"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Type I diabetes mellitus",4940]
["C=42;O=9;E=0.21;R=42.58;rawP=5.89e-13;adjP=1.30e-11"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Autoimmune thyroid disease",5320]
["C=51;O=9;E=0.26;R=35.06;rawP=3.87e-12;adjP=8.51e-11"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Viral myocarditis",5416]
["C=69;O=9;E=0.35;R=25.92;rawP=6.69e-11;adjP=1.47e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Antigen processing and presentation",4612]
["C=74;O=9;E=0.37;R=24.16;rawP=1.28e-10;adjP=2.82e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Phagosome",4145]
["C=150;O=10;E=0.75;R=13.25;rawP=4.59e-09;adjP=1.01e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-G"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["KEGG pathway","Asthma",5310]
["C=29;O=6;E=0.15;R=41.11;rawP=6.18e-09;adjP=1.36e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Cell adhesion molecules (CAMs)",4514]
["C=132;O=9;E=0.66;R=13.55;rawP=2.30e-08;adjP=5.06e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Intestinal immune network for IgA production",4672]
["C=47;O=6;E=0.24;R=25.36;rawP=1.30e-07;adjP=2.86e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Staphylococcus aureus infection",5150]
["C=54;O=6;E=0.27;R=22.08;rawP=3.03e-07;adjP=6.67e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Rheumatoid arthritis",5323]
["C=90;O=7;E=0.45;R=15.45;rawP=3.62e-07;adjP=7.96e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["ATP6V0E2"]
["HLA-DPB1"]
["KEGG pathway","Leishmaniasis",5140]
["C=71;O=6;E=0.36;R=16.79;rawP=1.57e-06;adjP=3.45e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Toxoplasmosis",5145]
["C=131;O=6;E=0.66;R=9.10;rawP=5.36e-05;adjP=0.0012"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Systemic lupus erythematosus",5322]
["C=135;O=6;E=0.68;R=8.83;rawP=6.34e-05;adjP=0.0014"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]

{"sheet":"S27","index":11,"n_rows":91,"n_cols":3,"rows_kept":91,"cut":false,"hidden":false,"merged":[]}
["S27. HKA PheWAS enrichment results - P.t. ellioti balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["PheWAS","Type 1 diabetic neuropathy","PheWAS:250.14"]
["C=54;O=7;E=0.70;R=10.07;rawP=2.51e-06;adjP=0.0010"]
["HLA-DRB1"]
["HLA-DRA"]
["CRHR1"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Lupus erythematosus","PheWAS:695.41"]
["C=45;O=6;E=0.58;R=10.36;rawP=1.29e-05;adjP=0.0052"]
["HLA-DPB2"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Type 1 diabetic retinopathy","PheWAS:250.13"]
["C=46;O=6;E=0.59;R=10.13;rawP=1.47e-05;adjP=0.0059"]
["HLA-DRA"]
["CRHR1"]
["HLA-C"]
["HLA-DQB1"]
["MAPT"]
["BTNL2"]
["PheWAS","Vaginitis and vulvovaginitis","PheWAS:614.52"]
["C=28;O=5;E=0.36;R=13.87;rawP=1.77e-05;adjP=0.0071"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-C"]
["HLA-DQB1"]
["BTNL2"]
["PheWAS","Type 1 diabetic ketoacidosis","PheWAS:250.11"]
["C=32;O=5;E=0.41;R=12.14;rawP=3.50e-05;adjP=0.0141"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["BTNL2"]
["PheWAS","Psoriasis vulgaris","PheWAS:696.41"]
["C=60;O=6;E=0.77;R=7.77;rawP=7.01e-05;adjP=0.0282"]
["HLA-B"]
["CRHR1"]
["HLA-C"]
["MINPP1"]
["HLA-DQB1"]
["MAPT"]
["PheWAS","Diseases of the larynx and vocal cords","PheWAS:473"]
["C=93;O=7;E=1.20;R=5.85;rawP=9.84e-05;adjP=0.0396"]
["C1orf63"]
["HLA-DRB1"]
["HLA-DRA"]
["CRHR1"]
["HLA-C"]
["HLA-DQB1"]
["LCE3E"]
["PheWAS","Visual disturbances","PheWAS:368"]
["C=167;O=9;E=2.15;R=4.19;rawP=0.0001;adjP=0.0402"]
["HLA-DRB1"]
["HLA-B"]
["CRHR1"]
["HLA-DQB1"]
["LCE3E"]
["FBN2"]
["HLA-C"]
["MAPT"]
["BTNL2"]
["PheWAS","Celiac disease","PheWAS:557.11"]
["C=40;O=5;E=0.51;R=9.71;rawP=0.0001;adjP=0.0402"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Type 1 diabetes","PheWAS:250.1"]
["C=167;O=9;E=2.15;R=4.19;rawP=0.0001;adjP=0.0402"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["CRHR1"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DPB1"]
["MAPT"]
["BTNL2"]

{"sheet":"S28","index":12,"n_rows":758,"n_cols":3,"rows_kept":758,"cut":false,"hidden":false,"merged":[]}
["S28. HKA GO enrichment results - P.t. schweinfurthii balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["biological process","interferon-gamma-mediated signaling pathway","GO:0060333"]
["C=74;O=8;E=0.26;R=31.17;rawP=1.48e-10;adjP=6.30e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","anatomical structure maturation","GO:0071695"]
["C=217;O=11;E=0.75;R=14.61;rawP=1.56e-10;adjP=6.65e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["FGFR3"]
["HLA-DQA1"]
["HLA-DQB1"]
["CYP2C19"]
["HLA-C"]
["HLA-DPB1"]
["PSMD5"]
["biological process","exogen","GO:0042638"]
["C=178;O=10;E=0.62;R=16.20;rawP=4.29e-10;adjP=1.83e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["CYP2C19"]
["HLA-C"]
["HLA-DPB1"]
["PSMD5"]
["biological process","cellular response to interferon-gamma","GO:0071346"]
["C=89;O=8;E=0.31;R=25.91;rawP=6.66e-10;adjP=2.84e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","hair follicle maturation","GO:0048820"]
["C=192;O=10;E=0.67;R=15.02;rawP=8.99e-10;adjP=3.83e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["CYP2C19"]
["HLA-C"]
["HLA-DPB1"]
["PSMD5"]
["biological process","response to interferon-gamma","GO:0034341"]
["C=108;O=8;E=0.37;R=21.36;rawP=3.16e-09;adjP=1.35e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of exogenous peptide antigen","GO:0002478"]
["C=167;O=9;E=0.58;R=15.54;rawP=5.05e-09;adjP=2.15e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["PSMD5"]
["biological process","antigen processing and presentation of exogenous antigen","GO:0019884"]
["C=169;O=9;E=0.59;R=15.35;rawP=5.61e-09;adjP=2.39e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["PSMD5"]
["biological process","antigen processing and presentation of peptide antigen","GO:0048002"]
["C=185;O=9;E=0.64;R=14.03;rawP=1.24e-08;adjP=5.28e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["PSMD5"]
["biological process","molting cycle process","GO:0022404"]
["C=256;O=10;E=0.89;R=11.26;rawP=1.44e-08;adjP=6.13e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["CYP2C19"]
["HLA-C"]
["HLA-DPB1"]
["PSMD5"]
["biological process","hair follicle development","GO:0001942"]
["C=256;O=10;E=0.89;R=11.26;rawP=1.44e-08;adjP=6.13e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["CYP2C19"]
["HLA-C"]
["HLA-DPB1"]
["PSMD5"]
["biological process","hair cycle process","GO:0022405"]
["C=256;O=10;E=0.89;R=11.26;rawP=1.44e-08;adjP=6.13e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["CYP2C19"]
["HLA-C"]
["HLA-DPB1"]
["PSMD5"]
["biological process","hair cycle","GO:0042633"]
["C=262;O=10;E=0.91;R=11.00;rawP=1.80e-08;adjP=7.67e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["CYP2C19"]
["HLA-C"]
["HLA-DPB1"]
["PSMD5"]
["biological process","molting cycle","GO:0042303"]
["C=262;O=10;E=0.91;R=11.00;rawP=1.80e-08;adjP=7.67e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["CYP2C19"]
["HLA-C"]
["HLA-DPB1"]
["PSMD5"]
["biological process","developmental maturation","GO:0021700"]
["C=349;O=11;E=1.21;R=9.09;rawP=2.30e-08;adjP=9.80e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["FGFR3"]
["HLA-DQA1"]
["HLA-DQB1"]
["CYP2C19"]
["HLA-C"]
["HLA-DPB1"]
["PSMD5"]
["biological process","epidermis development","GO:0008544"]
["C=454;O=12;E=1.57;R=7.62;rawP=3.37e-08;adjP=1.44e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["SPRR2G"]
["HLA-DQA1"]
["HLA-DQB1"]
["CYP2C19"]
["HLA-C"]
["HLA-DPB1"]
["SPRR2B"]
["PSMD5"]
["biological process","antigen processing and presentation","GO:0019882"]
["C=215;O=9;E=0.75;R=12.07;rawP=4.56e-08;adjP=1.94e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["PSMD5"]
["biological process","T cell costimulation","GO:0031295"]
["C=67;O=6;E=0.23;R=25.82;rawP=1.09e-07;adjP=4.64e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","lymphocyte costimulation","GO:0031294"]
["C=68;O=6;E=0.24;R=25.44;rawP=1.19e-07;adjP=5.07e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen receptor-mediated signaling pathway","GO:0050851"]
["C=117;O=7;E=0.41;R=17.25;rawP=1.45e-07;adjP=6.18e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["PRKCB"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","immune response-activating cell surface receptor signaling pathway","GO:0002429"]
["C=126;O=7;E=0.44;R=16.02;rawP=2.41e-07;adjP=0.0001"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["PRKCB"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","immune response-regulating cell surface receptor signaling pathway","GO:0002768"]
["C=137;O=7;E=0.48;R=14.73;rawP=4.27e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["PRKCB"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of exogenous peptide antigen via MHC class II","GO:0019886"]
["C=91;O=6;E=0.32;R=19.01;rawP=6.81e-07;adjP=0.0003"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","T cell receptor signaling pathway","GO:0050852"]
["C=93;O=6;E=0.32;R=18.60;rawP=7.75e-07;adjP=0.0003"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of peptide or polysaccharide antigen via MHC class II","GO:0002504"]
["C=95;O=6;E=0.33;R=18.21;rawP=8.79e-07;adjP=0.0004"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of peptide antigen via MHC class II","GO:0002495"]
["C=94;O=6;E=0.33;R=18.40;rawP=8.25e-07;adjP=0.0004"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","immune response-activating signal transduction","GO:0002757"]
["C=229;O=8;E=0.79;R=10.07;rawP=1.08e-06;adjP=0.0005"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["PRKCB"]
["HLA-DQA1"]
["HLA-DQB1"]
["PELI2"]
["HLA-DPB1"]
["biological process","innate immune response","GO:0045087"]
["C=516;O=11;E=1.79;R=6.15;rawP=1.17e-06;adjP=0.0005"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["PIK3C3"]
["HLA-DQA1"]
["HLA-DQB1"]
["PELI2"]
["HLA-C"]
["HLA-DPB1"]
["PGLYRP4"]
["biological process","regulation of immune response","GO:0050776"]
["C=528;O=11;E=1.83;R=6.01;rawP=1.47e-06;adjP=0.0006"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["PRKCB"]
["HLA-DQA1"]
["HLA-DQB1"]
["PELI2"]
["HLA-C"]
["HLA-DPB1"]
["PGLYRP4"]
["biological process","immune response-regulating signaling pathway","GO:0002764"]
["C=242;O=8;E=0.84;R=9.53;rawP=1.64e-06;adjP=0.0007"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["PRKCB"]
["HLA-DQA1"]
["HLA-DQB1"]
["PELI2"]
["HLA-DPB1"]
["biological process","activation of immune response","GO:0002253"]
["C=278;O=8;E=0.96;R=8.30;rawP=4.60e-06;adjP=0.0020"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["PRKCB"]
["HLA-DQA1"]
["HLA-DQB1"]
["PELI2"]
["HLA-DPB1"]
["biological process","cytokine-mediated signaling pathway","GO:0019221"]
["C=338;O=8;E=1.17;R=6.82;rawP=1.91e-05;adjP=0.0081"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","positive regulation of T cell activation","GO:0050870"]
["C=165;O=6;E=0.57;R=10.48;rawP=2.15e-05;adjP=0.0092"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","positive regulation of immune response","GO:0050778"]
["C=346;O=8;E=1.20;R=6.67;rawP=2.26e-05;adjP=0.0096"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["PRKCB"]
["HLA-DQA1"]
["HLA-DQB1"]
["PELI2"]
["HLA-DPB1"]
["biological process","detection of bacterium","GO:0016045"]
["C=17;O=3;E=0.06;R=50.88;rawP=2.58e-05;adjP=0.0110"]
["HLA-DRB1"]
["HLA-B"]
["PGLYRP4"]
["biological process","regulation of lymphocyte activation","GO:0051249"]
["C=285;O=7;E=0.99;R=7.08;rawP=5.29e-05;adjP=0.0225"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["PGLYRP4"]
["biological process","cellular response to cytokine stimulus","GO:0071345"]
["C=410;O=8;E=1.42;R=5.63;rawP=7.54e-05;adjP=0.0321"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","positive regulation of lymphocyte activation","GO:0051251"]
["C=209;O=6;E=0.72;R=8.28;rawP=8.07e-05;adjP=0.0344"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","detection of biotic stimulus","GO:0009595"]
["C=25;O=3;E=0.09;R=34.60;rawP=8.56e-05;adjP=0.0365"]
["HLA-DRB1"]
["HLA-B"]
["PGLYRP4"]
["biological process","regulation of T cell activation","GO:0050863"]
["C=219;O=6;E=0.76;R=7.90;rawP=0.0001;adjP=0.0426"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["molecular function",null,"GO:0032395"]
["C=11;O=5;E=0.03;R=148.13;rawP=9.91e-11;adjP=6.34e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["molecular function","ammonium transmembrane transporter activity","GO:0008519"]
["C=5;O=2;E=0.02;R=130.36;rawP=9.16e-05;adjP=0.0059"]
["RHCE"]
["RHD"]
["cellular component","integral to lumenal side of endoplasmic reticulum membrane","GO:0071556"]
["C=27;O=8;E=0.11;R=76.08;rawP=7.09e-14;adjP=7.16e-12"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","ER to Golgi transport vesicle membrane","GO:0012507"]
["C=36;O=8;E=0.14;R=57.06;rawP=9.40e-13;adjP=9.49e-11"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","MHC protein complex","GO:0042611"]
["C=37;O=8;E=0.14;R=55.52;rawP=1.20e-12;adjP=1.21e-10"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","ER to Golgi transport vesicle","GO:0030134"]
["C=40;O=8;E=0.16;R=51.36;rawP=2.36e-12;adjP=2.38e-10"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","MHC class II protein complex","GO:0042613"]
["C=15;O=6;E=0.06;R=102.71;rawP=1.34e-11;adjP=1.35e-09"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","endocytic vesicle membrane","GO:0030666"]
["C=92;O=9;E=0.36;R=25.12;rawP=7.81e-11;adjP=7.89e-09"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","transport vesicle membrane","GO:0030658"]
["C=75;O=8;E=0.29;R=27.39;rawP=4.66e-10;adjP=4.71e-08"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","trans-Golgi network membrane","GO:0032588"]
["C=30;O=6;E=0.12;R=51.36;rawP=1.52e-09;adjP=1.54e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","clathrin-coated endocytic vesicle membrane","GO:0030669"]
["C=32;O=6;E=0.12;R=48.15;rawP=2.31e-09;adjP=2.33e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","endocytic vesicle","GO:0030139"]
["C=148;O=9;E=0.58;R=15.62;rawP=5.56e-09;adjP=5.62e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","clathrin-coated endocytic vesicle","GO:0045334"]
["C=37;O=6;E=0.14;R=41.64;rawP=5.83e-09;adjP=5.89e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","integral to endoplasmic reticulum membrane","GO:0030176"]
["C=105;O=8;E=0.41;R=19.56;rawP=7.02e-09;adjP=7.09e-07"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","intrinsic to endoplasmic reticulum membrane","GO:0031227"]
["C=122;O=8;E=0.48;R=16.84;rawP=2.30e-08;adjP=2.32e-06"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","trans-Golgi network","GO:0005802"]
["C=126;O=8;E=0.49;R=16.30;rawP=2.97e-08;adjP=3.00e-06"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["SCAMP1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["KIAA1244"]
["cellular component","transport vesicle","GO:0030133"]
["C=144;O=8;E=0.56;R=14.27;rawP=8.41e-08;adjP=8.49e-06"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","coated vesicle membrane","GO:0030662"]
["C=149;O=8;E=0.58;R=13.79;rawP=1.10e-07;adjP=1.11e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","endosome membrane","GO:0010008"]
["C=311;O=10;E=1.21;R=8.26;rawP=3.16e-07;adjP=3.19e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["SCAMP1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","endosomal part","GO:0044440"]
["C=320;O=10;E=1.25;R=8.02;rawP=4.10e-07;adjP=4.14e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["SCAMP1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","endosome","GO:0005768"]
["C=556;O=12;E=2.17;R=5.54;rawP=1.33e-06;adjP=0.0001"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["PIK3C3"]
["SCAMP1"]
["HLA-DQA1"]
["HLA-DQB1"]
["AVL9"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","integral to organelle membrane","GO:0031301"]
["C=205;O=8;E=0.80;R=10.02;rawP=1.25e-06;adjP=0.0001"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","intrinsic to organelle membrane","GO:0031300"]
["C=227;O=8;E=0.88;R=9.05;rawP=2.68e-06;adjP=0.0003"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","clathrin-coated vesicle membrane","GO:0030665"]
["C=109;O=6;E=0.42;R=14.13;rawP=4.08e-06;adjP=0.0004"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","cytoplasmic vesicle membrane","GO:0030659"]
["C=340;O=9;E=1.32;R=6.80;rawP=6.36e-06;adjP=0.0006"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","coated vesicle","GO:0030135"]
["C=253;O=8;E=0.99;R=8.12;rawP=5.97e-06;adjP=0.0006"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","vesicle membrane","GO:0012506"]
["C=353;O=9;E=1.37;R=6.55;rawP=8.61e-06;adjP=0.0009"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","lysosomal membrane","GO:0005765"]
["C=139;O=6;E=0.54;R=11.08;rawP=1.65e-05;adjP=0.0017"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","cytoplasmic vesicle part","GO:0044433"]
["C=398;O=9;E=1.55;R=5.81;rawP=2.24e-05;adjP=0.0023"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","vacuolar membrane","GO:0005774"]
["C=182;O=6;E=0.71;R=8.47;rawP=7.50e-05;adjP=0.0076"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","clathrin-coated vesicle","GO:0030136"]
["C=206;O=6;E=0.80;R=7.48;rawP=0.0001;adjP=0.0101"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","vacuole","GO:0005773"]
["C=403;O=8;E=1.57;R=5.10;rawP=0.0002;adjP=0.0202"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["FGFR3"]
["HLA-DQA1"]
["HLA-DQB1"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","Golgi membrane","GO:0000139"]
["C=547;O=9;E=2.13;R=4.22;rawP=0.0003;adjP=0.0303"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-C"]
["NDST4"]
["HLA-DPB1"]
["cellular component","phagocytic vesicle membrane","GO:0030670"]
["C=32;O=3;E=0.12;R=24.07;rawP=0.0003;adjP=0.0303"]
["HLA-B"]
["HLA-C"]
["ATP6V0E2"]
["cellular component","vacuolar part","GO:0044437"]
["C=251;O=6;E=0.98;R=6.14;rawP=0.0004;adjP=0.0404"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","lysosome","GO:0005764"]
["C=341;O=7;E=1.33;R=5.27;rawP=0.0004;adjP=0.0404"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["FGFR3"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","lytic vacuole","GO:0000323"]
["C=341;O=7;E=1.33;R=5.27;rawP=0.0004;adjP=0.0404"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DPA1"]
["FGFR3"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]

{"sheet":"S29","index":13,"n_rows":146,"n_cols":3,"rows_kept":146,"cut":false,"hidden":false,"merged":[]}
["S29. HKA KEGG enrichment results - P.t. schweinfurthii balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["KEGG pathway","Allograft rejection",5330]
["C=36;O=8;E=0.18;R=43.78;rawP=9.33e-12;adjP=2.43e-10"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Graft-versus-host disease",5332]
["C=40;O=8;E=0.20;R=39.40;rawP=2.33e-11;adjP=6.06e-10"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Type I diabetes mellitus",4940]
["C=42;O=8;E=0.21;R=37.53;rawP=3.55e-11;adjP=9.23e-10"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Autoimmune thyroid disease",5320]
["C=51;O=8;E=0.26;R=30.90;rawP=1.84e-10;adjP=4.78e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Viral myocarditis",5416]
["C=69;O=8;E=0.35;R=22.84;rawP=2.24e-09;adjP=5.82e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Antigen processing and presentation",4612]
["C=74;O=8;E=0.38;R=21.30;rawP=3.96e-09;adjP=1.03e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Phagosome",4145]
["C=150;O=10;E=0.76;R=13.13;rawP=4.98e-09;adjP=1.29e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["PIK3C3"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["KEGG pathway","Asthma",5310]
["C=29;O=6;E=0.15;R=40.76;rawP=6.50e-09;adjP=1.69e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Leishmaniasis",5140]
["C=71;O=7;E=0.36;R=19.42;rawP=7.38e-08;adjP=1.92e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["PRKCB"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Intestinal immune network for IgA production",4672]
["C=47;O=6;E=0.24;R=25.15;rawP=1.36e-07;adjP=3.54e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Staphylococcus aureus infection",5150]
["C=54;O=6;E=0.27;R=21.89;rawP=3.19e-07;adjP=8.29e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Cell adhesion molecules (CAMs)",4514]
["C=132;O=8;E=0.67;R=11.94;rawP=3.79e-07;adjP=9.85e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Rheumatoid arthritis",5323]
["C=90;O=7;E=0.46;R=15.32;rawP=3.83e-07;adjP=9.96e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["ATP6V0E2"]
["HLA-DPB1"]
["KEGG pathway","Toxoplasmosis",5145]
["C=131;O=6;E=0.66;R=9.02;rawP=5.62e-05;adjP=0.0015"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Systemic lupus erythematosus",5322]
["C=135;O=6;E=0.69;R=8.76;rawP=6.64e-05;adjP=0.0017"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]

{"sheet":"S30","index":14,"n_rows":119,"n_cols":3,"rows_kept":119,"cut":false,"hidden":false,"merged":[]}
["S30. HKA PheWAS enrichment results - P.t. schweinfurthii balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["PheWAS","Lupus erythematosus","PheWAS:695.41"]
["C=45;O=7;E=0.55;R=12.66;rawP=4.80e-07;adjP=0.0002"]
["HLA-DPB2"]
["HLA-DRA"]
["HLA-B"]
["ZNRD1"]
["HLA-DQB1"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Type 1 diabetic ketoacidosis","PheWAS:250.11"]
["C=32;O=6;E=0.39;R=15.26;rawP=1.18e-06;adjP=0.0004"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-F-AS1"]
["HLA-DQB1"]
["BTNL2"]
["PheWAS","Bullous dermatoses","PheWAS:695.2"]
["C=37;O=6;E=0.45;R=13.20;rawP=2.90e-06;adjP=0.0011"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-F-AS1"]
["ZNRD1"]
["ZNRD1-AS1"]
["HLA-DQB1"]
["PheWAS","Discoid lupus erythematosus","PheWAS:695.4"]
["C=85;O=8;E=1.04;R=7.66;rawP=3.23e-06;adjP=0.0012"]
["HLA-DPB2"]
["HLA-DRA"]
["HLA-B"]
["ZNRD1"]
["ZNRD1-AS1"]
["HLA-DQB1"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Celiac disease","PheWAS:557.11"]
["C=40;O=6;E=0.49;R=12.21;rawP=4.69e-06;adjP=0.0017"]
["HLA-DRA"]
["HLA-B"]
["ZNRD1"]
["HLA-DQB1"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Vaginitis and vulvovaginitis","PheWAS:614.52"]
["C=28;O=5;E=0.34;R=14.53;rawP=1.38e-05;adjP=0.0051"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-C"]
["HLA-DQB1"]
["BTNL2"]
["PheWAS","Systemic lupus erythematosus","PheWAS:695.42"]
["C=49;O=6;E=0.60;R=9.97;rawP=1.59e-05;adjP=0.0059"]
["HLA-DRA"]
["HLA-B"]
["ZNRD1"]
["ZNRD1-AS1"]
["HLA-DQB1"]
["BTNL2"]
["PheWAS","Celiac or tropical sprue","PheWAS:557.1"]
["C=50;O=6;E=0.61;R=9.77;rawP=1.80e-05;adjP=0.0066"]
["HLA-DRA"]
["HLA-B"]
["ZNRD1"]
["HLA-DQB1"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Type 1 diabetic neuropathy","PheWAS:250.14"]
["C=54;O=6;E=0.66;R=9.04;rawP=2.83e-05;adjP=0.0104"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Myeloid leukemia","PheWAS:204.2"]
["C=38;O=5;E=0.47;R=10.71;rawP=6.52e-05;adjP=0.0241"]
["ZNRD1"]
["MIPEP"]
["HLA-DQB1"]
["CYP2C19"]
["BTNL2"]
["PheWAS","Type 1 diabetes nephropathy","PheWAS:250.12"]
["C=38;O=5;E=0.47;R=10.71;rawP=6.52e-05;adjP=0.0241"]
["HLA-DRB1"]
["HLA-DRA"]
["ZNRD1"]
["HLA-DQB1"]
["BTNL2"]
["PheWAS","Type 1 diabetes","PheWAS:250.1"]
["C=167;O=9;E=2.05;R=4.39;rawP=6.88e-05;adjP=0.0254"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-F-AS1"]
["HLA-C"]
["ZNRD1"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Retinoschisis and retinal cysts","PheWAS:361.2"]
["C=39;O=5;E=0.48;R=10.43;rawP=7.42e-05;adjP=0.0274"]
["HLA-DRA"]
["HLA-B"]
["ZNRD1"]
["HLA-DQB1"]
["BTNL2"]
["PheWAS","Persistent mental disorders due to other conditions","PheWAS:290.3"]
["C=41;O=5;E=0.50;R=9.92;rawP=9.50e-05;adjP=0.0351"]
["C1orf63"]
["HLA-DPB2"]
["HLA-C"]
["TMEM50A"]
["CYP2C19"]

{"sheet":"S31","index":15,"n_rows":814,"n_cols":3,"rows_kept":814,"cut":false,"hidden":false,"merged":[]}
["S31. HKA GO enrichment results - P.t. troglodytes balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["biological process","interferon-gamma-mediated signaling pathway","GO:0060333"]
["C=74;O=8;E=0.27;R=29.40;rawP=2.41e-10;adjP=1.47e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["biological process","cellular response to interferon-gamma","GO:0071346"]
["C=89;O=8;E=0.33;R=24.45;rawP=1.08e-09;adjP=6.58e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["biological process","response to interferon-gamma","GO:0034341"]
["C=108;O=8;E=0.40;R=20.15;rawP=5.12e-09;adjP=3.12e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["biological process","anatomical structure maturation","GO:0071695"]
["C=217;O=10;E=0.80;R=12.53;rawP=5.38e-09;adjP=3.28e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["FGFR3"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["PSMD5"]
["biological process","epidermis development","GO:0008544"]
["C=454;O=13;E=1.67;R=7.79;rawP=6.75e-09;adjP=4.11e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["SPRR2G"]
["HLA-DQA1"]
["HLA-DQB1"]
["SCEL"]
["HLA-F"]
["HLA-C"]
["KRTAP5-9"]
["HLA-DPB1"]
["SPRR2B"]
["PSMD5"]
["biological process","antigen processing and presentation of exogenous peptide antigen","GO:0002478"]
["C=167;O=9;E=0.61;R=14.66;rawP=8.67e-09;adjP=5.28e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["PSMD5"]
["biological process","antigen processing and presentation of exogenous antigen","GO:0019884"]
["C=169;O=9;E=0.62;R=14.48;rawP=9.62e-09;adjP=5.86e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["PSMD5"]
["biological process","exogen","GO:0042638"]
["C=178;O=9;E=0.65;R=13.75;rawP=1.51e-08;adjP=9.20e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["PSMD5"]
["biological process","antigen processing and presentation of peptide antigen","GO:0048002"]
["C=185;O=9;E=0.68;R=13.23;rawP=2.12e-08;adjP=1.29e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["PSMD5"]
["biological process","hair follicle maturation","GO:0048820"]
["C=192;O=9;E=0.71;R=12.75;rawP=2.92e-08;adjP=1.78e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["PSMD5"]
["biological process","antigen processing and presentation","GO:0019882"]
["C=215;O=9;E=0.79;R=11.39;rawP=7.75e-08;adjP=4.72e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["PSMD5"]
["biological process","hair cycle process","GO:0022405"]
["C=256;O=9;E=0.94;R=9.56;rawP=3.42e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["PSMD5"]
["biological process","tissue development","GO:0009888"]
["C=1445;O=19;E=5.31;R=3.58;rawP=3.94e-07;adjP=0.0002"]
["HLA-DQA1"]
["SCEL"]
["BCL9"]
["HLA-F"]
["FBN2"]
["HLA-DPB1"]
["HLA-DRB1"]
["HLA-DPA1"]
["FGFR3"]
["HLA-B"]
["HLA-DQB1"]
["SPRR2G"]
["DLG1"]
["SVIL"]
["HLA-C"]
["DVL1"]
["KRTAP5-9"]
["SPRR2B"]
["PSMD5"]
["biological process","molting cycle process","GO:0022404"]
["C=256;O=9;E=0.94;R=9.56;rawP=3.42e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["PSMD5"]
["biological process","hair follicle development","GO:0001942"]
["C=256;O=9;E=0.94;R=9.56;rawP=3.42e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["PSMD5"]
["biological process","hair cycle","GO:0042633"]
["C=262;O=9;E=0.96;R=9.34;rawP=4.16e-07;adjP=0.0003"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["PSMD5"]
["biological process","developmental maturation","GO:0021700"]
["C=349;O=10;E=1.28;R=7.79;rawP=4.70e-07;adjP=0.0003"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["FGFR3"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["PSMD5"]
["biological process","molting cycle","GO:0042303"]
["C=262;O=9;E=0.96;R=9.34;rawP=4.16e-07;adjP=0.0003"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["PSMD5"]
["biological process","cytokine-mediated signaling pathway","GO:0019221"]
["C=338;O=9;E=1.24;R=7.24;rawP=3.44e-06;adjP=0.0021"]
["ZNF675"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent","GO:0002480"]
["C=9;O=3;E=0.03;R=90.66;rawP=3.88e-06;adjP=0.0024"]
["HLA-B"]
["HLA-C"]
["HLA-F"]
["biological process","T cell costimulation","GO:0031295"]
["C=67;O=5;E=0.25;R=20.30;rawP=4.50e-06;adjP=0.0027"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","lymphocyte costimulation","GO:0031294"]
["C=68;O=5;E=0.25;R=20.00;rawP=4.84e-06;adjP=0.0029"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","organ development","GO:0048513"]
["C=2541;O=23;E=9.34;R=2.46;rawP=1.10e-05;adjP=0.0067"]
["ZNF675"]
["HLA-DQA1"]
["SCEL"]
["BCL9"]
["HLA-F"]
["FBN2"]
["HLA-DPB1"]
["PGLYRP4"]
["PLEK"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["FGFR3"]
["SPRR2G"]
["HLA-DQB1"]
["DLG1"]
["SVIL"]
["DVL1"]
["MSH4"]
["HLA-C"]
["KRTAP5-9"]
["SPRR2B"]
["PSMD5"]
["biological process","cellular response to cytokine stimulus","GO:0071345"]
["C=410;O=9;E=1.51;R=5.97;rawP=1.63e-05;adjP=0.0099"]
["ZNF675"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of exogenous peptide antigen via MHC class II","GO:0019886"]
["C=91;O=5;E=0.33;R=14.94;rawP=2.03e-05;adjP=0.0124"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","T cell receptor signaling pathway","GO:0050852"]
["C=93;O=5;E=0.34;R=14.62;rawP=2.25e-05;adjP=0.0137"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of peptide antigen via MHC class II","GO:0002495"]
["C=94;O=5;E=0.35;R=14.47;rawP=2.37e-05;adjP=0.0144"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of peptide or polysaccharide antigen via MHC class II","GO:0002504"]
["C=95;O=5;E=0.35;R=14.31;rawP=2.50e-05;adjP=0.0152"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","detection of bacterium","GO:0016045"]
["C=17;O=3;E=0.06;R=48.00;rawP=3.08e-05;adjP=0.0188"]
["HLA-DRB1"]
["HLA-B"]
["PGLYRP4"]
["biological process","regulation of cell activation","GO:0050865"]
["C=347;O=8;E=1.28;R=6.27;rawP=3.58e-05;adjP=0.0218"]
["HLA-DPA1"]
["HLA-DRB1"]
["PLEK"]
["HLA-DQA1"]
["HLA-DQB1"]
["DLG1"]
["HLA-DPB1"]
["PGLYRP4"]
["biological process","antigen receptor-mediated signaling pathway","GO:0050851"]
["C=117;O=5;E=0.43;R=11.62;rawP=6.80e-05;adjP=0.0414"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","regulation of lymphocyte activation","GO:0051249"]
["C=285;O=7;E=1.05;R=6.68;rawP=7.76e-05;adjP=0.0473"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["DLG1"]
["PGLYRP4"]
["molecular function",null,"GO:0032395"]
["C=11;O=4;E=0.04;R=90.85;rawP=7.49e-08;adjP=6.82e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DQA1"]
["HLA-DQB1"]
["molecular function","signaling receptor activity","GO:0038023"]
["C=1278;O=16;E=5.12;R=3.13;rawP=2.88e-05;adjP=0.0026"]
["GPRC6A"]
["HLA-F"]
["OR10C1"]
["OR2H1"]
["OR5P3"]
["PGLYRP4"]
["FGFR3"]
["HLA-B"]
["OR11A1"]
["OR5AC2"]
["TAS1R3"]
["OR5V1"]
["HLA-C"]
["OR5P2"]
["LPHN3"]
["GFRA2"]
["molecular function","transmembrane signaling receptor activity","GO:0004888"]
["C=1184;O=15;E=4.74;R=3.17;rawP=4.76e-05;adjP=0.0043"]
["HLA-B"]
["FGFR3"]
["GPRC6A"]
["OR11A1"]
["HLA-F"]
["OR5AC2"]
["OR10C1"]
["TAS1R3"]
["OR2H1"]
["OR5V1"]
["OR5P2"]
["HLA-C"]
["OR5P3"]
["GFRA2"]
["LPHN3"]
["molecular function","receptor activity","GO:0004872"]
["C=1483;O=17;E=5.94;R=2.86;rawP=4.70e-05;adjP=0.0043"]
["GPRC6A"]
["HLA-F"]
["OR10C1"]
["OR2H1"]
["OR5P3"]
["PGLYRP4"]
["SUSD2"]
["FGFR3"]
["HLA-B"]
["OR11A1"]
["OR5AC2"]
["TAS1R3"]
["OR5V1"]
["HLA-C"]
["OR5P2"]
["GFRA2"]
["LPHN3"]
["molecular function","MHC class I receptor activity","GO:0032393"]
["C=19;O=3;E=0.08;R=39.45;rawP=5.64e-05;adjP=0.0051"]
["HLA-B"]
["HLA-C"]
["HLA-F"]
["molecular function","glycine N-acyltransferase activity","GO:0047961"]
["C=4;O=2;E=0.02;R=124.93;rawP=9.40e-05;adjP=0.0086"]
["GLYATL1"]
["GLYATL2"]
["molecular function","molecular transducer activity","GO:0060089"]
["C=1580;O=17;E=6.32;R=2.69;rawP=0.0001;adjP=0.0091"]
["GPRC6A"]
["HLA-F"]
["OR10C1"]
["OR2H1"]
["OR5P3"]
["PGLYRP4"]
["FGFR3"]
["HLA-B"]
["OR11A1"]
["OR5AC2"]
["TAS1R3"]
["OR5V1"]
["HLA-C"]
["OR5P2"]
["DVL1"]
["GFRA2"]
["LPHN3"]
["molecular function","signal transducer activity","GO:0004871"]
["C=1580;O=17;E=6.32;R=2.69;rawP=0.0001;adjP=0.0091"]
["GPRC6A"]
["HLA-F"]
["OR10C1"]
["OR2H1"]
["OR5P3"]
["PGLYRP4"]
["FGFR3"]
["HLA-B"]
["OR11A1"]
["OR5AC2"]
["TAS1R3"]
["OR5V1"]
["HLA-C"]
["OR5P2"]
["DVL1"]
["GFRA2"]
["LPHN3"]
["molecular function","ammonium transmembrane transporter activity","GO:0008519"]
["C=5;O=2;E=0.02;R=99.94;rawP=0.0002;adjP=0.0182"]
["RHCE"]
["RHD"]
["cellular component","integral to lumenal side of endoplasmic reticulum membrane","GO:0071556"]
["C=27;O=8;E=0.12;R=65.94;rawP=2.35e-13;adjP=2.91e-11"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["cellular component","ER to Golgi transport vesicle membrane","GO:0012507"]
["C=36;O=8;E=0.16;R=49.45;rawP=3.10e-12;adjP=3.84e-10"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["cellular component","MHC protein complex","GO:0042611"]
["C=37;O=8;E=0.17;R=48.12;rawP=3.94e-12;adjP=4.89e-10"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["cellular component","ER to Golgi transport vesicle","GO:0030134"]
["C=40;O=8;E=0.18;R=44.51;rawP=7.76e-12;adjP=9.62e-10"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["cellular component","endocytic vesicle membrane","GO:0030666"]
["C=92;O=9;E=0.41;R=21.77;rawP=2.93e-10;adjP=3.63e-08"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","transport vesicle membrane","GO:0030658"]
["C=75;O=8;E=0.34;R=23.74;rawP=1.50e-09;adjP=1.86e-07"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["cellular component","MHC class II protein complex","GO:0042613"]
["C=15;O=5;E=0.07;R=74.18;rawP=4.64e-09;adjP=5.75e-07"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","endocytic vesicle","GO:0030139"]
["C=148;O=9;E=0.67;R=13.53;rawP=2.03e-08;adjP=2.52e-06"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","integral to endoplasmic reticulum membrane","GO:0030176"]
["C=105;O=8;E=0.47;R=16.96;rawP=2.23e-08;adjP=2.77e-06"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["cellular component","intrinsic to endoplasmic reticulum membrane","GO:0031227"]
["C=122;O=8;E=0.55;R=14.59;rawP=7.24e-08;adjP=8.98e-06"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["cellular component","trans-Golgi network membrane","GO:0032588"]
["C=30;O=5;E=0.13;R=37.09;rawP=2.09e-07;adjP=2.59e-05"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","transport vesicle","GO:0030133"]
["C=144;O=8;E=0.65;R=12.36;rawP=2.62e-07;adjP=3.25e-05"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["cellular component","clathrin-coated endocytic vesicle membrane","GO:0030669"]
["C=32;O=5;E=0.14;R=34.77;rawP=2.93e-07;adjP=3.63e-05"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","coated vesicle membrane","GO:0030662"]
["C=149;O=8;E=0.67;R=11.95;rawP=3.40e-07;adjP=4.22e-05"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["cellular component","clathrin-coated endocytic vesicle","GO:0045334"]
["C=37;O=5;E=0.17;R=30.07;rawP=6.23e-07;adjP=7.73e-05"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","endosomal part","GO:0044440"]
["C=320;O=10;E=1.44;R=6.95;rawP=1.60e-06;adjP=0.0002"]
["HLA-DRB1"]
["SLC9A9"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","endosome membrane","GO:0010008"]
["C=311;O=10;E=1.40;R=7.16;rawP=1.24e-06;adjP=0.0002"]
["HLA-DRB1"]
["SLC9A9"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","coated vesicle","GO:0030135"]
["C=253;O=9;E=1.14;R=7.92;rawP=1.92e-06;adjP=0.0002"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["DVL1"]
["HLA-C"]
["HLA-DPB1"]
["cellular component","integral to organelle membrane","GO:0031301"]
["C=205;O=8;E=0.92;R=8.68;rawP=3.77e-06;adjP=0.0005"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["cellular component","intrinsic to organelle membrane","GO:0031300"]
["C=227;O=8;E=1.02;R=7.84;rawP=7.97e-06;adjP=0.0010"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-C"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["HLA-F"]
["cellular component","phagocytic vesicle membrane","GO:0030670"]
["C=32;O=4;E=0.14;R=27.82;rawP=1.23e-05;adjP=0.0015"]
["HLA-B"]
["HLA-C"]
["HLA-F"]
["ATP6V0E2"]
["cellular component","cytoplasmic vesicle membrane","GO:0030659"]
["C=340;O=9;E=1.53;R=5.89;rawP=2.09e-05;adjP=0.0026"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","vesicle membrane","GO:0012506"]
["C=353;O=9;E=1.59;R=5.67;rawP=2.81e-05;adjP=0.0035"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","cytoplasmic vesicle part","GO:0044433"]
["C=398;O=9;E=1.79;R=5.03;rawP=7.12e-05;adjP=0.0088"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","phagocytic vesicle","GO:0045335"]
["C=50;O=4;E=0.22;R=17.80;rawP=7.40e-05;adjP=0.0092"]
["HLA-B"]
["HLA-C"]
["HLA-F"]
["ATP6V0E2"]
["cellular component","cornified envelope","GO:0001533"]
["C=23;O=3;E=0.10;R=29.03;rawP=0.0001;adjP=0.0124"]
["SPRR2G"]
["SCEL"]
["SPRR2B"]
["cellular component","MHC class I protein complex","GO:0042612"]
["C=22;O=3;E=0.10;R=30.35;rawP=0.0001;adjP=0.0124"]
["HLA-B"]
["HLA-C"]
["HLA-F"]
["cellular component","clathrin-coated vesicle membrane","GO:0030665"]
["C=109;O=5;E=0.49;R=10.21;rawP=0.0001;adjP=0.0124"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","endosome","GO:0005768"]
["C=556;O=10;E=2.50;R=4.00;rawP=0.0002;adjP=0.0248"]
["HLA-DRB1"]
["SLC9A9"]
["HLA-DPA1"]
["HLA-B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-F"]
["HLA-C"]
["ATP6V0E2"]
["HLA-DPB1"]
["cellular component","plasma membrane","GO:0005886"]
["C=4193;O=33;E=18.84;R=1.75;rawP=0.0003;adjP=0.0372"]
["RHCE"]
["SCEL"]
["HLA-F"]
["DIO2"]
["OR10C1"]
["RHD"]
["OR2H1"]
["OR5P3"]
["ENOX1"]
["HLA-DPB1"]
["HLA-DRB1"]
["PLEK"]
["HLA-DPA1"]
["FGFR3"]
["MUC16"]
["OR11A1"]
["HLA-DQB1"]
["OR5AC2"]
["DLG1"]
["OR5V1"]
["HLA-C"]
["EMCN"]
["GPRC6A"]
["HLA-DQA1"]
["CDH12"]
["HLA-B"]
["XKR3"]
["TAS1R3"]
["SVIL"]
["DVL1"]
["OR5P2"]
["LPHN3"]
["GFRA2"]
["cellular component","clathrin-coated vesicle","GO:0030136"]
["C=206;O=6;E=0.93;R=6.48;rawP=0.0003;adjP=0.0372"]
["HLA-DRB1"]
["HLA-DPA1"]
["DVL1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","trans-Golgi network","GO:0005802"]
["C=126;O=5;E=0.57;R=8.83;rawP=0.0003;adjP=0.0372"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","lysosomal membrane","GO:0005765"]
["C=139;O=5;E=0.62;R=8.01;rawP=0.0004;adjP=0.0496"]
["HLA-DRB1"]
["HLA-DPA1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","cell periphery","GO:0071944"]
["C=4281;O=33;E=19.24;R=1.72;rawP=0.0004;adjP=0.0496"]
["RHCE"]
["SCEL"]
["HLA-F"]
["DIO2"]
["OR10C1"]
["RHD"]
["OR2H1"]
["OR5P3"]
["ENOX1"]
["HLA-DPB1"]
["HLA-DRB1"]
["PLEK"]
["HLA-DPA1"]
["FGFR3"]
["MUC16"]
["OR11A1"]
["HLA-DQB1"]
["OR5AC2"]
["DLG1"]
["OR5V1"]
["HLA-C"]
["EMCN"]
["GPRC6A"]
["HLA-DQA1"]
["CDH12"]
["HLA-B"]
["XKR3"]
["TAS1R3"]
["SVIL"]
["DVL1"]
["OR5P2"]
["LPHN3"]
["GFRA2"]

{"sheet":"S32","index":16,"n_rows":137,"n_cols":3,"rows_kept":137,"cut":false,"hidden":false,"merged":[]}
["S32. HKA KEGG enrichment results - P.t. troglodytes balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["KEGG pathway","Allograft rejection",5330]
["C=36;O=8;E=0.20;R=40.70;rawP=1.68e-11;adjP=3.70e-10"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["HLA-F"]
["KEGG pathway","Graft-versus-host disease",5332]
["C=40;O=8;E=0.22;R=36.63;rawP=4.20e-11;adjP=9.24e-10"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["HLA-F"]
["KEGG pathway","Type I diabetes mellitus",4940]
["C=42;O=8;E=0.23;R=34.89;rawP=6.39e-11;adjP=1.41e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["HLA-F"]
["KEGG pathway","Autoimmune thyroid disease",5320]
["C=51;O=8;E=0.28;R=28.73;rawP=3.31e-10;adjP=7.28e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["HLA-F"]
["KEGG pathway","Viral myocarditis",5416]
["C=69;O=8;E=0.38;R=21.24;rawP=4.00e-09;adjP=8.80e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["HLA-F"]
["KEGG pathway","Antigen processing and presentation",4612]
["C=74;O=8;E=0.40;R=19.80;rawP=7.05e-09;adjP=1.55e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["HLA-F"]
["KEGG pathway","Phagosome",4145]
["C=150;O=9;E=0.82;R=10.99;rawP=1.41e-07;adjP=3.10e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-C"]
["HLA-DPB1"]
["ATP6V0E2"]
["KEGG pathway","Asthma",5310]
["C=29;O=5;E=0.16;R=31.58;rawP=4.79e-07;adjP=1.05e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Cell adhesion molecules (CAMs)",4514]
["C=132;O=8;E=0.72;R=11.10;rawP=6.62e-07;adjP=1.46e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-B"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["HLA-F"]
["KEGG pathway","Intestinal immune network for IgA production",4672]
["C=47;O=5;E=0.26;R=19.49;rawP=5.72e-06;adjP=0.0001"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Rheumatoid arthritis",5323]
["C=90;O=6;E=0.49;R=12.21;rawP=1.01e-05;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DQB1"]
["HLA-DQA1"]
["ATP6V0E2"]
["HLA-DPB1"]
["KEGG pathway","Staphylococcus aureus infection",5150]
["C=54;O=5;E=0.29;R=16.96;rawP=1.14e-05;adjP=0.0003"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Leishmaniasis",5140]
["C=71;O=5;E=0.39;R=12.90;rawP=4.38e-05;adjP=0.0010"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Toxoplasmosis",5145]
["C=131;O=5;E=0.72;R=6.99;rawP=0.0008;adjP=0.0176"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Systemic lupus erythematosus",5322]
["C=135;O=5;E=0.74;R=6.78;rawP=0.0009;adjP=0.0198"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]

{"sheet":"S33","index":17,"n_rows":13,"n_cols":3,"rows_kept":13,"cut":false,"hidden":false,"merged":[]}
["S33. HKA PheWAS enrichment results - P.t. troglodytes balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["PheWAS","Prostate cancer","PheWAS:185"]
["C=52;O=5;E=0.55;R=9.13;rawP=0.0001;adjP=0.0292"]
["HLA-B"]
["HLA-C"]
["TMEM50A"]
["HLA-DQB1"]
["HLA-DPB1"]

{"sheet":"S34","index":18,"n_rows":158,"n_cols":3,"rows_kept":158,"cut":false,"hidden":false,"merged":[]}
["S34. HKA KEGG enrichment results - P.t. verus balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["KEGG pathway","Allograft rejection",5330]
["C=36;O=10;E=0.20;R=49.34;rawP=5.08e-15;adjP=1.07e-13"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Graft-versus-host disease",5332]
["C=40;O=10;E=0.23;R=44.40;rawP=1.66e-14;adjP=3.49e-13"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Type I diabetes mellitus",4940]
["C=42;O=10;E=0.24;R=42.29;rawP=2.86e-14;adjP=6.01e-13"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Autoimmune thyroid disease",5320]
["C=51;O=10;E=0.29;R=34.83;rawP=2.38e-13;adjP=5.00e-12"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Viral myocarditis",5416]
["C=69;O=10;E=0.39;R=25.74;rawP=5.81e-12;adjP=1.22e-10"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Antigen processing and presentation",4612]
["C=74;O=10;E=0.42;R=24.00;rawP=1.20e-11;adjP=2.52e-10"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Cell adhesion molecules (CAMs)",4514]
["C=132;O=10;E=0.74;R=13.46;rawP=3.96e-09;adjP=8.32e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Asthma",5310]
["C=29;O=6;E=0.16;R=36.75;rawP=1.21e-08;adjP=2.54e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Phagosome",4145]
["C=150;O=10;E=0.84;R=11.84;rawP=1.36e-08;adjP=2.86e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-F"]
["HLA-G"]
["HLA-C"]
["HLA-DPB1"]
["KEGG pathway","Intestinal immune network for IgA production",4672]
["C=47;O=6;E=0.26;R=22.67;rawP=2.52e-07;adjP=5.29e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Staphylococcus aureus infection",5150]
["C=54;O=6;E=0.30;R=19.73;rawP=5.88e-07;adjP=1.23e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Leishmaniasis",5140]
["C=71;O=6;E=0.40;R=15.01;rawP=3.01e-06;adjP=6.32e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Rheumatoid arthritis",5323]
["C=90;O=6;E=0.51;R=11.84;rawP=1.20e-05;adjP=0.0003"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Systemic lupus erythematosus",5322]
["C=135;O=6;E=0.76;R=7.89;rawP=0.0001;adjP=0.0021"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Toxoplasmosis",5145]
["C=131;O=6;E=0.74;R=8.13;rawP=9.99e-05;adjP=0.0021"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]

{"sheet":"S35","index":19,"n_rows":144,"n_cols":3,"rows_kept":144,"cut":false,"hidden":false,"merged":[]}
["S35. HKA PheWAS enrichment results - P.t. verus balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["PheWAS","Bullous dermatoses","PheWAS:695.2"]
["C=37;O=8;E=0.52;R=15.40;rawP=1.25e-08;adjP=4.99e-06"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-F-AS1"]
["ZNRD1-AS1"]
["ZNRD1"]
["HLA-DQB1"]
["LCE3D"]
["PSORS1C1"]
["PheWAS","Discoid lupus erythematosus","PheWAS:695.4"]
["C=85;O=9;E=1.19;R=7.54;rawP=8.66e-07;adjP=0.0003"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["HLA-F"]
["HLA-DPB2"]
["ZNRD1"]
["ZNRD1-AS1"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Lupus erythematosus","PheWAS:695.41"]
["C=45;O=7;E=0.63;R=11.08;rawP=1.35e-06;adjP=0.0005"]
["HLA-DPB2"]
["HLA-DRA"]
["HLA-B"]
["ZNRD1"]
["HLA-DQB1"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Systemic lupus erythematosus","PheWAS:695.42"]
["C=49;O=7;E=0.69;R=10.17;rawP=2.46e-06;adjP=0.0010"]
["HLA-DRA"]
["HLA-B"]
["ZNRD1-AS1"]
["ZNRD1"]
["HLA-DQB1"]
["HLA-F"]
["BTNL2"]
["PheWAS","Celiac or tropical sprue","PheWAS:557.1"]
["C=50;O=7;E=0.70;R=9.97;rawP=2.83e-06;adjP=0.0011"]
["HLA-DRA"]
["HLA-B"]
["ZNRD1"]
["HLA-DQB1"]
["HLA-DPB1"]
["BTNL2"]
["PSORS1C1"]
["PheWAS","Type 1 diabetic ketoacidosis","PheWAS:250.11"]
["C=32;O=6;E=0.45;R=13.35;rawP=2.80e-06;adjP=0.0011"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-F-AS1"]
["HLA-DQB1"]
["BTNL2"]
["PheWAS","Type 1 diabetic neuropathy","PheWAS:250.14"]
["C=54;O=7;E=0.76;R=9.23;rawP=4.84e-06;adjP=0.0019"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-C"]
["HLA-DQB1"]
["HLA-DPB1"]
["BTNL2"]
["NAV3"]
["PheWAS","Retinoschisis and retinal cysts","PheWAS:361.2"]
["C=39;O=6;E=0.55;R=10.96;rawP=9.47e-06;adjP=0.0038"]
["HLA-DRA"]
["HLA-B"]
["ZNRD1"]
["HLA-DQB1"]
["BTNL2"]
["PSORS1C1"]
["PheWAS","Celiac disease","PheWAS:557.11"]
["C=40;O=6;E=0.56;R=10.68;rawP=1.10e-05;adjP=0.0044"]
["HLA-DRA"]
["HLA-B"]
["ZNRD1"]
["HLA-DQB1"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Erythematous conditions","PheWAS:695"]
["C=279;O=13;E=3.92;R=3.32;rawP=2.05e-05;adjP=0.0082"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-B"]
["HLA-DQB1"]
["LCE3D"]
["HLA-F"]
["HLA-DPB2"]
["HLA-F-AS1"]
["ZNRD1-AS1"]
["ZNRD1"]
["HLA-DPB1"]
["BTNL2"]
["PSORS1C1"]
["PheWAS","Seborheic dermatitis","PheWAS:690"]
["C=45;O=6;E=0.63;R=9.49;rawP=2.24e-05;adjP=0.0089"]
["HLA-B"]
["HLA-C"]
["HCG22"]
["HLA-DQB1"]
["NAV3"]
["PSORS1C1"]
["PheWAS","Vaginitis and vulvovaginitis","PheWAS:614.52"]
["C=28;O=5;E=0.39;R=12.72;rawP=2.79e-05;adjP=0.0111"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-C"]
["HLA-DQB1"]
["BTNL2"]
["PheWAS","Type 1 diabetes","PheWAS:250.1"]
["C=167;O=10;E=2.35;R=4.26;rawP=3.56e-05;adjP=0.0142"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-F-AS1"]
["HLA-C"]
["ZNRD1"]
["HLA-DPB1"]
["BTNL2"]
["NAV3"]
["PheWAS","Prostate cancer","PheWAS:185"]
["C=52;O=6;E=0.73;R=8.22;rawP=5.24e-05;adjP=0.0209"]
["HLA-B"]
["HLA-C"]
["TMEM50A"]
["HLA-DQB1"]
["HLA-DPB1"]
["PSORS1C1"]
["PheWAS","Type 1 diabetes nephropathy","PheWAS:250.12"]
["C=38;O=5;E=0.53;R=9.37;rawP=0.0001;adjP=0.0399"]
["HLA-DRB1"]
["HLA-DRA"]
["ZNRD1"]
["HLA-DQB1"]
["BTNL2"]

{"sheet":"S36","index":20,"n_rows":861,"n_cols":3,"rows_kept":861,"cut":false,"hidden":false,"merged":[]}
["S36. HKA GO enrichment results - P. abelii balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["biological process","antigen processing and presentation","GO:0019882"]
["C=215;O=10;E=0.55;R=18.12;rawP=1.08e-10;adjP=3.70e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["MICA"]
["RAET1L"]
["HLA-G"]
["HLA-H"]
["HLA-DPB1"]
["biological process","interferon-gamma-mediated signaling pathway","GO:0060333"]
["C=74;O=7;E=0.19;R=36.85;rawP=6.40e-10;adjP=2.20e-07"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","immune response-regulating cell surface receptor signaling pathway","GO:0002768"]
["C=137;O=8;E=0.35;R=22.75;rawP=1.66e-09;adjP=5.69e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["MICA"]
["HLA-G"]
["HLA-DPB1"]
["biological process","cellular response to interferon-gamma","GO:0071346"]
["C=89;O=7;E=0.23;R=30.64;rawP=2.38e-09;adjP=8.16e-07"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","response to interferon-gamma","GO:0034341"]
["C=108;O=7;E=0.28;R=25.25;rawP=9.32e-09;adjP=3.20e-06"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","T cell costimulation","GO:0031295"]
["C=67;O=6;E=0.17;R=34.89;rawP=1.67e-08;adjP=5.73e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of peptide antigen","GO:0048002"]
["C=185;O=8;E=0.47;R=16.85;rawP=1.78e-08;adjP=6.11e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-H"]
["HLA-DPB1"]
["biological process","lymphocyte costimulation","GO:0031294"]
["C=68;O=6;E=0.17;R=34.38;rawP=1.82e-08;adjP=6.24e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","immune response-activating cell surface receptor signaling pathway","GO:0002429"]
["C=126;O=7;E=0.32;R=21.64;rawP=2.73e-08;adjP=9.36e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["MICA"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of exogenous peptide antigen via MHC class II","GO:0019886"]
["C=91;O=6;E=0.23;R=25.69;rawP=1.06e-07;adjP=3.64e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","T cell receptor signaling pathway","GO:0050852"]
["C=93;O=6;E=0.24;R=25.14;rawP=1.21e-07;adjP=4.15e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of peptide antigen via MHC class II","GO:0002495"]
["C=94;O=6;E=0.24;R=24.87;rawP=1.29e-07;adjP=4.42e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","cytokine-mediated signaling pathway","GO:0019221"]
["C=338;O=9;E=0.87;R=10.37;rawP=1.34e-07;adjP=4.60e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["EIF4A3"]
["HLA-G"]
["HLA-DPB1"]
["ISG15"]
["biological process","antigen processing and presentation of peptide or polysaccharide antigen via MHC class II","GO:0002504"]
["C=95;O=6;E=0.24;R=24.61;rawP=1.38e-07;adjP=4.73e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","immune response-regulating signaling pathway","GO:0002764"]
["C=242;O=8;E=0.62;R=12.88;rawP=1.43e-07;adjP=4.90e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["MICA"]
["HLA-G"]
["HLA-DPB1"]
["biological process","lymphocyte activation","GO:0046649"]
["C=461;O=10;E=1.18;R=8.45;rawP=1.63e-07;adjP=5.59e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["EXOSC3"]
["MICA"]
["HLA-G"]
["HLA-DPB1"]
["TNFRSF13B"]
["biological process","positive regulation of T cell activation","GO:0050870"]
["C=165;O=7;E=0.42;R=16.53;rawP=1.75e-07;adjP=6.00e-05"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of exogenous peptide antigen","GO:0002478"]
["C=167;O=7;E=0.43;R=16.33;rawP=1.90e-07;adjP=6.52e-05"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen processing and presentation of exogenous antigen","GO:0019884"]
["C=169;O=7;E=0.43;R=16.14;rawP=2.06e-07;adjP=7.07e-05"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","exogen","GO:0042638"]
["C=178;O=7;E=0.46;R=15.32;rawP=2.93e-07;adjP=0.0001"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","antigen receptor-mediated signaling pathway","GO:0050851"]
["C=117;O=6;E=0.30;R=19.98;rawP=4.76e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","regulation of lymphocyte activation","GO:0051249"]
["C=285;O=8;E=0.73;R=10.94;rawP=4.97e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-DPB1"]
["TNFRSF13B"]
["biological process","hair follicle maturation","GO:0048820"]
["C=192;O=7;E=0.49;R=14.20;rawP=4.89e-07;adjP=0.0002"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","cellular response to cytokine stimulus","GO:0071345"]
["C=410;O=9;E=1.05;R=8.55;rawP=6.85e-07;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["EIF4A3"]
["HLA-G"]
["HLA-DPB1"]
["ISG15"]
["biological process","positive regulation of lymphocyte activation","GO:0051251"]
["C=209;O=7;E=0.54;R=13.05;rawP=8.67e-07;adjP=0.0003"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","leukocyte activation","GO:0045321"]
["C=547;O=10;E=1.40;R=7.12;rawP=7.87e-07;adjP=0.0003"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["EXOSC3"]
["MICA"]
["HLA-G"]
["HLA-DPB1"]
["TNFRSF13B"]
["biological process","regulation of T cell activation","GO:0050863"]
["C=219;O=7;E=0.56;R=12.45;rawP=1.19e-06;adjP=0.0004"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","anatomical structure maturation","GO:0071695"]
["C=217;O=7;E=0.56;R=12.57;rawP=1.12e-06;adjP=0.0004"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","positive regulation of leukocyte activation","GO:0002696"]
["C=228;O=7;E=0.59;R=11.96;rawP=1.55e-06;adjP=0.0005"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","regulation of leukocyte activation","GO:0002694"]
["C=325;O=8;E=0.83;R=9.59;rawP=1.34e-06;adjP=0.0005"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-DPB1"]
["TNFRSF13B"]
["biological process","T cell activation","GO:0042110"]
["C=332;O=8;E=0.85;R=9.39;rawP=1.57e-06;adjP=0.0005"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["MICA"]
["HLA-G"]
["HLA-DPB1"]
["biological process","immune response-activating signal transduction","GO:0002757"]
["C=229;O=7;E=0.59;R=11.91;rawP=1.60e-06;adjP=0.0005"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["MICA"]
["HLA-DPB1"]
["biological process","defense response","GO:0006952"]
["C=1076;O=13;E=2.76;R=4.71;rawP=1.36e-06;adjP=0.0005"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HTN3"]
["HCP5"]
["HLA-DQA1"]
["HLA-DQB1"]
["MICA"]
["HTN1"]
["HLA-G"]
["SP140"]
["HLA-DPB1"]
["ISG15"]
["biological process","positive regulation of cell activation","GO:0050867"]
["C=236;O=7;E=0.61;R=11.56;rawP=1.95e-06;adjP=0.0007"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","regulation of cell activation","GO:0050865"]
["C=347;O=8;E=0.89;R=8.98;rawP=2.18e-06;adjP=0.0007"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-DPB1"]
["TNFRSF13B"]
["biological process","molting cycle process","GO:0022404"]
["C=256;O=7;E=0.66;R=10.65;rawP=3.35e-06;adjP=0.0011"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","hair follicle development","GO:0001942"]
["C=256;O=7;E=0.66;R=10.65;rawP=3.35e-06;adjP=0.0011"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","hair cycle process","GO:0022405"]
["C=256;O=7;E=0.66;R=10.65;rawP=3.35e-06;adjP=0.0011"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["biological process","response to cytokine stimulus","GO:0034097"]
["C=505;O=9;E=1.30;R=6.94;rawP=3.83e-06;adjP=0.0013"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["EIF4A3"]
["HLA-G"]
["HLA-DPB1"]
["ISG15"]
["biological process","molting cycle","GO:0042303"]
["C=262;O=7;E=0.67;R=10.41;rawP=3.91e-06;adjP=0.0013"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["molecular function",null,"GO:0032395"]
["C=11;O=5;E=0.03;R=174.72;rawP=4.17e-11;adjP=2.34e-09"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["molecular function","olfactory receptor activity","GO:0004984"]
["C=377;O=11;E=0.98;R=11.22;rawP=1.96e-09;adjP=1.10e-07"]
["OR10H1"]
["OR10H5"]
["OR1B1"]
["OR11H6"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["OR9Q1"]
["OR6Q1"]
["OR4K5"]
["OR11G2"]
["molecular function","G-protein coupled receptor activity","GO:0004930"]
["C=816;O=11;E=2.12;R=5.18;rawP=4.78e-06;adjP=0.0003"]
["OR10H1"]
["OR10H5"]
["OR1B1"]
["OR11H6"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["OR9Q1"]
["OR6Q1"]
["OR4K5"]
["OR11G2"]
["molecular function","transmembrane signaling receptor activity","GO:0004888"]
["C=1184;O=13;E=3.08;R=4.22;rawP=5.06e-06;adjP=0.0003"]
["OR10H1"]
["OR10H5"]
["OR1B1"]
["OR11H6"]
["HLA-G"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["HLA-H"]
["OR9Q1"]
["OR6Q1"]
["OR4K5"]
["OR11G2"]
["molecular function","receptor activity","GO:0004872"]
["C=1483;O=14;E=3.86;R=3.63;rawP=1.13e-05;adjP=0.0006"]
["OR10H1"]
["OR10H5"]
["OR1B1"]
["OR11H6"]
["HLA-G"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["HLA-H"]
["OR9Q1"]
["OR6Q1"]
["TNFRSF13B"]
["OR4K5"]
["OR11G2"]
["molecular function","signaling receptor activity","GO:0038023"]
["C=1278;O=13;E=3.32;R=3.91;rawP=1.17e-05;adjP=0.0007"]
["OR10H1"]
["OR10H5"]
["OR1B1"]
["OR11H6"]
["HLA-G"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["HLA-H"]
["OR9Q1"]
["OR6Q1"]
["OR4K5"]
["OR11G2"]
["molecular function","signal transducer activity","GO:0004871"]
["C=1580;O=13;E=4.11;R=3.16;rawP=0.0001;adjP=0.0056"]
["OR10H1"]
["OR10H5"]
["OR1B1"]
["OR11H6"]
["HLA-G"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["HLA-H"]
["OR9Q1"]
["OR6Q1"]
["OR4K5"]
["OR11G2"]
["molecular function","molecular transducer activity","GO:0060089"]
["C=1580;O=13;E=4.11;R=3.16;rawP=0.0001;adjP=0.0056"]
["OR10H1"]
["OR10H5"]
["OR1B1"]
["OR11H6"]
["HLA-G"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["HLA-H"]
["OR9Q1"]
["OR6Q1"]
["OR4K5"]
["OR11G2"]
["cellular component","MHC protein complex","GO:0042611"]
["C=37;O=10;E=0.12;R=86.75;rawP=1.12e-17;adjP=1.16e-15"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["MICA"]
["RAET1L"]
["HLA-G"]
["HLA-H"]
["HLA-DPB1"]
["cellular component","integral to lumenal side of endoplasmic reticulum membrane","GO:0071556"]
["C=27;O=7;E=0.08;R=83.22;rawP=1.58e-12;adjP=1.64e-10"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","MHC class II protein complex","GO:0042613"]
["C=15;O=6;E=0.05;R=128.39;rawP=3.32e-12;adjP=3.45e-10"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","ER to Golgi transport vesicle membrane","GO:0012507"]
["C=36;O=7;E=0.11;R=62.41;rawP=1.46e-11;adjP=1.52e-09"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","ER to Golgi transport vesicle","GO:0030134"]
["C=40;O=7;E=0.12;R=56.17;rawP=3.23e-11;adjP=3.36e-09"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","trans-Golgi network membrane","GO:0032588"]
["C=30;O=6;E=0.09;R=64.20;rawP=3.81e-10;adjP=3.96e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","clathrin-coated endocytic vesicle membrane","GO:0030669"]
["C=32;O=6;E=0.10;R=60.18;rawP=5.78e-10;adjP=6.01e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","clathrin-coated endocytic vesicle","GO:0045334"]
["C=37;O=6;E=0.12;R=52.05;rawP=1.47e-09;adjP=1.53e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","transport vesicle membrane","GO:0030658"]
["C=75;O=7;E=0.23;R=29.96;rawP=3.16e-09;adjP=3.29e-07"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","endocytic vesicle membrane","GO:0030666"]
["C=92;O=7;E=0.29;R=24.42;rawP=1.34e-08;adjP=1.39e-06"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","integral to endoplasmic reticulum membrane","GO:0030176"]
["C=105;O=7;E=0.33;R=21.40;rawP=3.38e-08;adjP=3.52e-06"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","intrinsic to endoplasmic reticulum membrane","GO:0031227"]
["C=122;O=7;E=0.38;R=18.42;rawP=9.55e-08;adjP=9.93e-06"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","trans-Golgi network","GO:0005802"]
["C=126;O=7;E=0.39;R=17.83;rawP=1.19e-07;adjP=1.24e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["PSD3"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","lysosomal membrane","GO:0005765"]
["C=139;O=7;E=0.43;R=16.16;rawP=2.34e-07;adjP=2.43e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["GAA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","transport vesicle","GO:0030133"]
["C=144;O=7;E=0.45;R=15.60;rawP=2.97e-07;adjP=3.09e-05"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","endocytic vesicle","GO:0030139"]
["C=148;O=7;E=0.46;R=15.18;rawP=3.58e-07;adjP=3.72e-05"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","coated vesicle membrane","GO:0030662"]
["C=149;O=7;E=0.46;R=15.08;rawP=3.75e-07;adjP=3.90e-05"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","MHC class I protein complex","GO:0042612"]
["C=22;O=4;E=0.07;R=58.36;rawP=5.88e-07;adjP=6.12e-05"]
["HLA-G"]
["HLA-H"]
["MICA"]
["RAET1L"]
["cellular component","coated vesicle","GO:0030135"]
["C=253;O=8;E=0.79;R=10.15;rawP=1.06e-06;adjP=0.0001"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["DOC2B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-G"]
["HLA-DPB1"]
["cellular component","vacuolar membrane","GO:0005774"]
["C=182;O=7;E=0.57;R=12.35;rawP=1.44e-06;adjP=0.0001"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["GAA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","clathrin-coated vesicle membrane","GO:0030665"]
["C=109;O=6;E=0.34;R=17.67;rawP=1.08e-06;adjP=0.0001"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","plasma membrane","GO:0005886"]
["C=4193;O=29;E=13.06;R=2.22;rawP=2.33e-06;adjP=0.0002"]
["KANK1"]
["HLA-DRA"]
["KCTD7"]
["OR10H1"]
["DOC2B"]
["HLA-DQA1"]
["OR1B1"]
["PCDH15"]
["PSD3"]
["HLA-H"]
["OR9Q1"]
["TNFRSF13B"]
["HLA-DPB1"]
["OR4K5"]
["HLA-DRB1"]
["HLA-DPA1"]
["XKR3"]
["OR10H5"]
["ABCC6"]
["HLA-DQB1"]
["MICA"]
["RAET1L"]
["OR11H6"]
["HLA-G"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["OR6Q1"]
["OR11G2"]
["cellular component","clathrin-coated vesicle","GO:0030136"]
["C=206;O=7;E=0.64;R=10.91;rawP=3.29e-06;adjP=0.0003"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["DOC2B"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","integral to organelle membrane","GO:0031301"]
["C=205;O=7;E=0.64;R=10.96;rawP=3.19e-06;adjP=0.0003"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","cell periphery","GO:0071944"]
["C=4281;O=29;E=13.34;R=2.17;rawP=3.66e-06;adjP=0.0004"]
["KANK1"]
["HLA-DRA"]
["KCTD7"]
["OR10H1"]
["DOC2B"]
["HLA-DQA1"]
["OR1B1"]
["PCDH15"]
["PSD3"]
["HLA-H"]
["OR9Q1"]
["TNFRSF13B"]
["HLA-DPB1"]
["OR4K5"]
["HLA-DRB1"]
["HLA-DPA1"]
["XKR3"]
["OR10H5"]
["ABCC6"]
["HLA-DQB1"]
["MICA"]
["RAET1L"]
["OR11H6"]
["HLA-G"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["OR6Q1"]
["OR11G2"]
["cellular component","intrinsic to organelle membrane","GO:0031300"]
["C=227;O=7;E=0.71;R=9.90;rawP=6.24e-06;adjP=0.0006"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","vacuolar part","GO:0044437"]
["C=251;O=7;E=0.78;R=8.95;rawP=1.20e-05;adjP=0.0012"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["GAA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","endosome membrane","GO:0010008"]
["C=311;O=7;E=0.97;R=7.22;rawP=4.75e-05;adjP=0.0049"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","endosomal part","GO:0044440"]
["C=320;O=7;E=1.00;R=7.02;rawP=5.69e-05;adjP=0.0059"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","cytoplasmic vesicle membrane","GO:0030659"]
["C=340;O=7;E=1.06;R=6.61;rawP=8.33e-05;adjP=0.0087"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","lytic vacuole","GO:0000323"]
["C=341;O=7;E=1.06;R=6.59;rawP=8.48e-05;adjP=0.0088"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["GAA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","lysosome","GO:0005764"]
["C=341;O=7;E=1.06;R=6.59;rawP=8.48e-05;adjP=0.0088"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["GAA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","vesicle membrane","GO:0012506"]
["C=353;O=7;E=1.10;R=6.37;rawP=0.0001;adjP=0.0104"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","vacuole","GO:0005773"]
["C=403;O=7;E=1.26;R=5.58;rawP=0.0002;adjP=0.0208"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["GAA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","cytoplasmic vesicle part","GO:0044433"]
["C=398;O=7;E=1.24;R=5.65;rawP=0.0002;adjP=0.0208"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]
["cellular component","endosome","GO:0005768"]
["C=556;O=8;E=1.73;R=4.62;rawP=0.0003;adjP=0.0312"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["RABGEF1"]
["HLA-DQA1"]
["HLA-DQB1"]
["HLA-DPB1"]

{"sheet":"S37","index":21,"n_rows":148,"n_cols":3,"rows_kept":148,"cut":false,"hidden":false,"merged":[]}
["S37. HKA KEGG enrichment results - P. abelii balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["KEGG pathway","Allograft rejection",5330]
["C=36;O=7;E=0.18;R=37.99;rawP=5.69e-10;adjP=1.08e-08"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Graft-versus-host disease",5332]
["C=40;O=7;E=0.20;R=34.19;rawP=1.25e-09;adjP=2.38e-08"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Type I diabetes mellitus",4940]
["C=42;O=7;E=0.21;R=32.56;rawP=1.79e-09;adjP=3.40e-08"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Intestinal immune network for IgA production",4672]
["C=47;O=7;E=0.24;R=29.10;rawP=4.09e-09;adjP=7.77e-08"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["TNFRSF13B"]
["HLA-DPB1"]
["KEGG pathway","Asthma",5310]
["C=29;O=6;E=0.15;R=40.42;rawP=6.84e-09;adjP=1.30e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Autoimmune thyroid disease",5320]
["C=51;O=7;E=0.26;R=26.82;rawP=7.41e-09;adjP=1.41e-07"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Viral myocarditis",5416]
["C=69;O=7;E=0.35;R=19.82;rawP=6.40e-08;adjP=1.22e-06"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Antigen processing and presentation",4612]
["C=74;O=7;E=0.38;R=18.48;rawP=1.05e-07;adjP=1.99e-06"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Staphylococcus aureus infection",5150]
["C=54;O=6;E=0.28;R=21.71;rawP=3.35e-07;adjP=6.37e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Leishmaniasis",5140]
["C=71;O=6;E=0.36;R=16.51;rawP=1.73e-06;adjP=3.29e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Olfactory transduction",4740]
["C=388;O=11;E=1.99;R=5.54;rawP=5.13e-06;adjP=9.75e-05"]
["OR10H1"]
["OR10H5"]
["OR1B1"]
["OR11H6"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["OR9Q1"]
["OR6Q1"]
["OR4K5"]
["OR11G2"]
["KEGG pathway","Rheumatoid arthritis",5323]
["C=90;O=6;E=0.46;R=13.03;rawP=6.95e-06;adjP=0.0001"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Cell adhesion molecules (CAMs)",4514]
["C=132;O=7;E=0.68;R=10.36;rawP=5.36e-06;adjP=0.0001"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Phagosome",4145]
["C=150;O=7;E=0.77;R=9.12;rawP=1.24e-05;adjP=0.0002"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Toxoplasmosis",5145]
["C=131;O=6;E=0.67;R=8.95;rawP=5.89e-05;adjP=0.0011"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Systemic lupus erythematosus",5322]
["C=135;O=6;E=0.69;R=8.68;rawP=6.96e-05;adjP=0.0013"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]

{"sheet":"S38","index":22,"n_rows":135,"n_cols":3,"rows_kept":135,"cut":false,"hidden":false,"merged":[]}
["S38. HKA PheWAS enrichment results - P. abelii balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["PheWAS","Type 1 diabetic ketoacidosis","PheWAS:250.11"]
["C=32;O=7;E=0.32;R=21.99;rawP=6.89e-09;adjP=2.37e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HCG9"]
["C6orf10"]
["BTNL2"]
["PheWAS","Discoid lupus erythematosus","PheWAS:695.4"]
["C=85;O=8;E=0.85;R=9.46;rawP=4.55e-07;adjP=0.0002"]
["HLA-DPB2"]
["HLA-DRA"]
["ZNRD1-AS1"]
["HLA-DQB1"]
["MICA"]
["HLA-DPB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Rosacea","PheWAS:695.3"]
["C=41;O=6;E=0.41;R=14.71;rawP=1.33e-06;adjP=0.0005"]
["HLA-DRB1"]
["HLA-DRA"]
["HCP5"]
["HLA-DQB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Lupus erythematosus","PheWAS:695.41"]
["C=45;O=6;E=0.45;R=13.40;rawP=2.36e-06;adjP=0.0008"]
["HLA-DPB2"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DPB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Rheumatoid arthritis","PheWAS:714.1"]
["C=53;O=6;E=0.53;R=11.38;rawP=6.37e-06;adjP=0.0022"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HCG9"]
["C6orf10"]
["BTNL2"]
["PheWAS","Type 1 diabetic neuropathy","PheWAS:250.14"]
["C=54;O=6;E=0.54;R=11.17;rawP=7.12e-06;adjP=0.0024"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DPB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Erythematous conditions","PheWAS:695"]
["C=279;O=11;E=2.78;R=3.96;rawP=9.01e-06;adjP=0.0031"]
["HLA-DRB1"]
["HLA-DRA"]
["HCP5"]
["HLA-DQB1"]
["HCG9"]
["MICA"]
["C6orf10"]
["HLA-DPB2"]
["ZNRD1-AS1"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Bullous dermatoses","PheWAS:695.2"]
["C=37;O=5;E=0.37;R=13.59;rawP=1.85e-05;adjP=0.0064"]
["HLA-DRB1"]
["HLA-DRA"]
["ZNRD1-AS1"]
["HLA-DQB1"]
["C6orf10"]
["PheWAS","Type 1 diabetes nephropathy","PheWAS:250.12"]
["C=38;O=5;E=0.38;R=13.23;rawP=2.12e-05;adjP=0.0073"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Rheumatoid arthritis & related inflammatory polyarthropathies","PheWAS:714"]
["C=66;O=6;E=0.66;R=9.14;rawP=2.34e-05;adjP=0.0080"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HCG9"]
["C6orf10"]
["BTNL2"]
["PheWAS","Celiac disease","PheWAS:557.11"]
["C=40;O=5;E=0.40;R=12.57;rawP=2.74e-05;adjP=0.0094"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DPB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Anorexia","PheWAS:260.6"]
["C=21;O=4;E=0.21;R=19.15;rawP=3.62e-05;adjP=0.0125"]
["HLA-DRB1"]
["HLA-DRA"]
["SP140"]
["HLA-DPB1"]
["PheWAS","Type 1 diabetes","PheWAS:250.1"]
["C=167;O=8;E=1.66;R=4.82;rawP=7.96e-05;adjP=0.0274"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HCG9"]
["HLA-DPB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Celiac or tropical sprue","PheWAS:557.1"]
["C=50;O=5;E=0.50;R=10.05;rawP=8.31e-05;adjP=0.0286"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DPB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Elevated prostate specific antigen","PheWAS:796"]
["C=50;O=5;E=0.50;R=10.05;rawP=8.31e-05;adjP=0.0286"]
["HLA-DPB2"]
["HLA-DRB1"]
["HLA-DQB1"]
["HLA-DPB1"]
["TNFRSF13B"]
["PheWAS","Vaginitis and vulvovaginitis","PheWAS:614.52"]
["C=28;O=4;E=0.28;R=14.36;rawP=0.0001;adjP=0.0344"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["BTNL2"]

{"sheet":"S39","index":23,"n_rows":146,"n_cols":3,"rows_kept":146,"cut":false,"hidden":false,"merged":[]}
["S39. HKA KEGG enrichment results - P. pygmaeus balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["KEGG pathway","Allograft rejection",5330]
["C=36;O=7;E=0.20;R=35.34;rawP=9.47e-10;adjP=2.18e-08"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Graft-versus-host disease",5332]
["C=40;O=7;E=0.22;R=31.81;rawP=2.08e-09;adjP=4.78e-08"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Type I diabetes mellitus",4940]
["C=42;O=7;E=0.23;R=30.29;rawP=2.98e-09;adjP=6.85e-08"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Intestinal immune network for IgA production",4672]
["C=47;O=7;E=0.26;R=27.07;rawP=6.79e-09;adjP=1.56e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["TNFRSF13B"]
["HLA-DPB1"]
["KEGG pathway","Asthma",5310]
["C=29;O=6;E=0.16;R=37.60;rawP=1.06e-08;adjP=2.44e-07"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Autoimmune thyroid disease",5320]
["C=51;O=7;E=0.28;R=24.95;rawP=1.23e-08;adjP=2.83e-07"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Viral myocarditis",5416]
["C=69;O=7;E=0.38;R=18.44;rawP=1.05e-07;adjP=2.41e-06"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Antigen processing and presentation",4612]
["C=74;O=7;E=0.41;R=17.19;rawP=1.72e-07;adjP=3.96e-06"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Staphylococcus aureus infection",5150]
["C=54;O=6;E=0.30;R=20.19;rawP=5.13e-07;adjP=1.18e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Phagosome",4145]
["C=150;O=8;E=0.83;R=9.69;rawP=1.85e-06;adjP=4.26e-05"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["DYNC2H1"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Leishmaniasis",5140]
["C=71;O=6;E=0.39;R=15.36;rawP=2.64e-06;adjP=6.07e-05"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Cell adhesion molecules (CAMs)",4514]
["C=132;O=7;E=0.73;R=9.64;rawP=8.64e-06;adjP=0.0002"]
["HLA-G"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Rheumatoid arthritis",5323]
["C=90;O=6;E=0.50;R=12.12;rawP=1.05e-05;adjP=0.0002"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Toxoplasmosis",5145]
["C=131;O=6;E=0.72;R=8.32;rawP=8.80e-05;adjP=0.0020"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Systemic lupus erythematosus",5322]
["C=135;O=6;E=0.74;R=8.08;rawP=0.0001;adjP=0.0023"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DQA1"]
["HLA-DPB1"]
["KEGG pathway","Olfactory transduction",4740]
["C=388;O=8;E=2.13;R=3.75;rawP=0.0014;adjP=0.0322"]
["OR7C1"]
["OR1B1"]
["OR1Q1"]
["OR4K15"]
["OR7A5"]
["OR2S2"]
["OR4K5"]
["OR13A1"]

{"sheet":"S40","index":24,"n_rows":159,"n_cols":3,"rows_kept":159,"cut":false,"hidden":false,"merged":[]}
["S40. HKA PheWAS enrichment results - P. pygmaeus balancing selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["PheWAS","Type 1 diabetic ketoacidosis","PheWAS:250.11"]
["C=32;O=7;E=0.36;R=19.68;rawP=1.74e-08;adjP=6.51e-06"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HCG9"]
["C6orf10"]
["BTNL2"]
["PheWAS","Type 1 diabetes nephropathy","PheWAS:250.12"]
["C=38;O=7;E=0.42;R=16.57;rawP=6.28e-08;adjP=2.35e-05"]
["HLA-DRB1"]
["HLA-DRA"]
["CUBN"]
["ZNRD1"]
["HLA-DQB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Discoid lupus erythematosus","PheWAS:695.4"]
["C=85;O=8;E=0.94;R=8.47;rawP=1.30e-06;adjP=0.0005"]
["HLA-DRA"]
["ZNRD1"]
["ZNRD1-AS1"]
["HLA-DQB1"]
["MICA"]
["HLA-DPB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Bullous dermatoses","PheWAS:695.2"]
["C=37;O=6;E=0.41;R=14.59;rawP=1.50e-06;adjP=0.0006"]
["HLA-DRB1"]
["HLA-DRA"]
["ZNRD1"]
["ZNRD1-AS1"]
["HLA-DQB1"]
["C6orf10"]
["PheWAS","Celiac disease","PheWAS:557.11"]
["C=40;O=6;E=0.44;R=13.49;rawP=2.43e-06;adjP=0.0009"]
["HLA-DRA"]
["ZNRD1"]
["HLA-DQB1"]
["HLA-DPB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Type 1 diabetes","PheWAS:250.1"]
["C=167;O=10;E=1.86;R=5.39;rawP=2.60e-06;adjP=0.0010"]
["HLA-DPA1"]
["HLA-DRB1"]
["HLA-DRA"]
["CUBN"]
["HLA-DQB1"]
["HCG9"]
["C6orf10"]
["ZNRD1"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Rosacea","PheWAS:695.3"]
["C=41;O=6;E=0.46;R=13.16;rawP=2.82e-06;adjP=0.0011"]
["HLA-DRB1"]
["HLA-DRA"]
["HCP5"]
["HLA-DQB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Erythematous conditions","PheWAS:695"]
["C=279;O=12;E=3.10;R=3.87;rawP=4.93e-06;adjP=0.0018"]
["HLA-DRB1"]
["HLA-DRA"]
["CUBN"]
["HCP5"]
["HLA-DQB1"]
["HCG9"]
["MICA"]
["C6orf10"]
["ZNRD1"]
["ZNRD1-AS1"]
["HLA-DPB1"]
["BTNL2"]
["PheWAS","Lupus erythematosus","PheWAS:695.41"]
["C=45;O=6;E=0.50;R=11.99;rawP=4.98e-06;adjP=0.0019"]
["HLA-DRA"]
["ZNRD1"]
["HLA-DQB1"]
["HLA-DPB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Celiac or tropical sprue","PheWAS:557.1"]
["C=50;O=6;E=0.56;R=10.79;rawP=9.39e-06;adjP=0.0035"]
["HLA-DRA"]
["ZNRD1"]
["HLA-DQB1"]
["HLA-DPB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Rheumatoid arthritis","PheWAS:714.1"]
["C=53;O=6;E=0.59;R=10.18;rawP=1.33e-05;adjP=0.0050"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HCG9"]
["C6orf10"]
["BTNL2"]
["PheWAS","Type 1 diabetic neuropathy","PheWAS:250.14"]
["C=54;O=6;E=0.60;R=9.99;rawP=1.49e-05;adjP=0.0056"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HLA-DPB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Megaloblastic anemia","PheWAS:281.1"]
["C=95;O=7;E=1.06;R=6.63;rawP=3.83e-05;adjP=0.0143"]
["HLA-DRB1"]
["HLA-DRA"]
["CUBN"]
["ADAMTSL3"]
["HLA-DQB1"]
["C6orf10"]
["BTNL2"]
["PheWAS","Rheumatoid arthritis & related inflammatory polyarthropathies","PheWAS:714"]
["C=66;O=6;E=0.73;R=8.18;rawP=4.83e-05;adjP=0.0181"]
["HLA-DRB1"]
["HLA-DRA"]
["HLA-DQB1"]
["HCG9"]
["C6orf10"]
["BTNL2"]
["PheWAS","Anorexia","PheWAS:260.6"]
["C=21;O=4;E=0.23;R=17.13;rawP=5.81e-05;adjP=0.0217"]
["HLA-DRB1"]
["HLA-DRA"]
["SP140"]
["HLA-DPB1"]
["PheWAS","Pernicious anemia","PheWAS:281.11"]
["C=43;O=5;E=0.48;R=10.46;rawP=7.13e-05;adjP=0.0267"]
["HLA-DRB1"]
["HLA-DRA"]
["ADAMTSL3"]
["C6orf10"]
["BTNL2"]
["PheWAS","Systemic lupus erythematosus","PheWAS:695.42"]
["C=49;O=5;E=0.54;R=9.18;rawP=0.0001;adjP=0.0374"]
["HLA-DRA"]
["ZNRD1"]
["ZNRD1-AS1"]
["HLA-DQB1"]
["BTNL2"]
["PheWAS","Calculus of ureter","PheWAS:594.3"]
["C=25;O=4;E=0.28;R=14.39;rawP=0.0001;adjP=0.0374"]
["HLA-DRB1"]
["CUBN"]
["HLA-DQB1"]
["BTNL2"]

{"sheet":"S41","index":25,"n_rows":290,"n_cols":3,"rows_kept":290,"cut":false,"hidden":false,"merged":[]}
["S41. HKA GO enrichment results - G.g. gorilla positive selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["biological process","cellular response to UV-B","GO:0071493"]
["C=5;O=3;E=0.03;R=101.75;rawP=1.96e-06;adjP=0.0015"]
["HYAL1"]
["HYAL3"]
["HYAL2"]
["biological process","hyaluronan catabolic process","GO:0030214"]
["C=13;O=3;E=0.08;R=39.14;rawP=5.42e-05;adjP=0.0426"]
["HYAL1"]
["HYAL3"]
["HYAL2"]
["molecular function","viral receptor activity","GO:0001618"]
["C=6;O=3;E=0.03;R=87.16;rawP=3.60e-06;adjP=0.0004"]
["HYAL1"]
["HYAL3"]
["HYAL2"]
["molecular function","hyalurononglucosaminidase activity","GO:0004415"]
["C=7;O=3;E=0.04;R=74.71;rawP=6.28e-06;adjP=0.0008"]
["HYAL1"]
["HYAL3"]
["HYAL2"]
["molecular function","hyaluronoglucuronidase activity","GO:0033906"]
["C=2;O=2;E=0.01;R=174.31;rawP=3.25e-05;adjP=0.0040"]
["HYAL3"]
["HYAL2"]
["molecular function","hexosaminidase activity","GO:0015929"]
["C=14;O=3;E=0.08;R=37.35;rawP=6.34e-05;adjP=0.0077"]
["HYAL1"]
["HYAL3"]
["HYAL2"]
["cellular component","cytoplasm","GO:0005737"]
["C=9027;O=73;E=53.54;R=1.36;rawP=4.37e-05;adjP=0.0060"]
["SPTBN2"]
["DMXL2"]
["TSC2"]
["CTSF"]
["SYT12"]
["POC1A"]
["KLC2"]
["NTN3"]
["CERS5"]
["RSL1D1"]
["ZMYND10"]
["FKBP2"]
["RBM4"]
["HYAL2"]
["PLCB3"]
["CNIH2"]
["AQP2"]
["BBS1"]
["COX14"]
["TBC1D24"]
["HYAL1"]
["TBX20"]
["ACTN3"]
["DDN"]
["TMEM115"]
["THAP11"]
["PRKAG1"]
["NUTF2"]
["CCNF"]
["CD2BP2"]
["TSNAXIP1"]
["BAD"]
["HYAL3"]
["C8orf82"]
["MAP4"]
["TRAIP"]
["FOSL1"]
["ARNT"]
["RHEBL1"]
["CAMKV"]
["GOLPH3L"]
["PARP14"]
["HNRNPH1"]
["CDK20"]
["CCS"]
["PARN"]
["WWP2"]
["GPD1"]
["DCTPP1"]
["RPL13"]
["NPRL2"]
["ADRBK1"]
["GAL3ST3"]
["RAB1B"]
["NAT6"]
["MRPL11"]
["CPSF4"]
["SGCB"]
["PTCD1"]
["DPP3"]
["ARHGAP39"]
["TUSC2"]
["PACS1"]
["PELI3"]
["ATP5J2"]
["CTSK"]
["YIF1A"]
["PC"]
["CCDC85B"]
["AQP5"]
["CENPT"]
["PPP1R14B"]
["PKD1"]
["cellular component","intracellular","GO:0005622"]
["C=12391;O=89;E=73.50;R=1.21;rawP=8.51e-05;adjP=0.0117"]
["SPTBN2"]
["DMXL2"]
["TSC2"]
["RBM4B"]
["CTSF"]
["SYT12"]
["POC1A"]
["KLC2"]
["NTN3"]
["CERS5"]
["RSL1D1"]
["ZMYND10"]
["FKBP2"]
["RBM4"]
["HYAL2"]
["PLCB3"]
["SF3B2"]
["CNIH2"]
["AQP2"]
["RBM14"]
["KDM2A"]
["BBS1"]
["COX14"]
["ZNF789"]
["TBC1D24"]
["HYAL1"]
["TBX20"]
["ACTN3"]
["ZNF394"]
["DDN"]
["TMEM115"]
["THAP11"]
["DRAP1"]
["PRKAG1"]
["NUTF2"]
["CCNF"]
["CBFB"]
["CD2BP2"]
["TSNAXIP1"]
["BAD"]
["HYAL3"]
["ZNF48"]
["C8orf82"]
["MAP4"]
["TRAIP"]
["FOSL1"]
["ARNT"]
["RPRD2"]
["RHEBL1"]
["HORMAD1"]
["CAMKV"]
["GOLPH3L"]
["PARP14"]
["ZNF768"]
["ZNF771"]
["HNRNPH1"]
["CDK20"]
["CCS"]
["PARN"]
["WWP2"]
["GPD1"]
["DCTPP1"]
["RPL13"]
["NPRL2"]
["ADRBK1"]
["RAB1B"]
["GAL3ST3"]
["NAT6"]
["CPSF4"]
["MRPL11"]
["SGCB"]
["PTCD1"]
["ARHGAP39"]
["DPP3"]
["PACS1"]
["TUSC2"]
["PELI3"]
["ATP5J2"]
["CTSK"]
["YIF1A"]
["PC"]
["ZNF747"]
["CCDC85B"]
["GSPT1"]
["AQP5"]
["CENPT"]
["PPP1R14B"]
["SMARCD1"]
["PKD1"]
["cellular component","intracellular part","GO:0044424"]
["C=12073;O=87;E=71.61;R=1.21;rawP=0.0002;adjP=0.0274"]
["SPTBN2"]
["DMXL2"]
["TSC2"]
["RBM4B"]
["CTSF"]
["SYT12"]
["POC1A"]
["KLC2"]
["NTN3"]
["CERS5"]
["RSL1D1"]
["ZMYND10"]
["FKBP2"]
["RBM4"]
["HYAL2"]
["PLCB3"]
["SF3B2"]
["CNIH2"]
["AQP2"]
["RBM14"]
["KDM2A"]
["BBS1"]
["COX14"]
["ZNF789"]
["TBC1D24"]
["HYAL1"]
["TBX20"]
["ACTN3"]
["ZNF394"]
["DDN"]
["TMEM115"]
["THAP11"]
["DRAP1"]
["PRKAG1"]
["NUTF2"]
["CCNF"]
["CBFB"]
["CD2BP2"]
["TSNAXIP1"]
["BAD"]
["HYAL3"]
["ZNF48"]
["C8orf82"]
["MAP4"]
["TRAIP"]
["FOSL1"]
["ARNT"]
["RPRD2"]
["RHEBL1"]
["HORMAD1"]
["CAMKV"]
["GOLPH3L"]
["PARP14"]
["ZNF768"]
["ZNF771"]
["HNRNPH1"]
["CDK20"]
["CCS"]
["PARN"]
["WWP2"]
["GPD1"]
["DCTPP1"]
["RPL13"]
["NPRL2"]
["ADRBK1"]
["RAB1B"]
["GAL3ST3"]
["NAT6"]
["CPSF4"]
["MRPL11"]
["SGCB"]
["PTCD1"]
["ARHGAP39"]
["DPP3"]
["PACS1"]
["TUSC2"]
["PELI3"]
["ATP5J2"]
["CTSK"]
["YIF1A"]
["PC"]
["CCDC85B"]
["AQP5"]
["CENPT"]
["PPP1R14B"]
["SMARCD1"]
["PKD1"]

{"sheet":"S42","index":26,"n_rows":11,"n_cols":3,"rows_kept":11,"cut":false,"hidden":false,"merged":[]}
["S42. HKA KEGG enrichment results - G.g. gorilla positive selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["KEGG pathway","Glycosaminoglycan degradation",531]
["C=19;O=3;E=0.10;R=28.70;rawP=0.0001;adjP=0.0021"]
["HYAL1"]
["HYAL3"]
["HYAL2"]

{"sheet":"S43","index":27,"n_rows":14,"n_cols":3,"rows_kept":14,"cut":false,"hidden":false,"merged":[]}
["S43. HKA PheWAS enrichment results - G.g. gorilla positive selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["PheWAS","Other paralytic syndromes","PheWAS:344"]
["C=40;O=2;E=0.09;R=21.36;rawP=0.0031;adjP=0.0310"]
["BAD"]
["PC"]
["PheWAS","Heart valve replaced","PheWAS:395.6"]
["C=43;O=2;E=0.10;R=19.87;rawP=0.0036;adjP=0.0360"]
["BAD"]
["NUTF2"]

{"sheet":"S44","index":28,"n_rows":27,"n_cols":4,"rows_kept":27,"cut":false,"hidden":false,"merged":[]}
["S44. HKA GO enrichment results - H. sapiens positive selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["molecular function","hydrolase activity","hydrolyzing O-glycosyl compounds","GO:0004553"]
["C=92;O=5;E=0.41;R=12.16;rawP=5.58e-05;adjP=0.0064"]
["GAA"]
["AMY2B"]
["GUSB"]
["HYAL4"]
["PHKB"]
["molecular function","hydrolase activity","acting on glycosyl bonds","GO:0016798"]
["C=116;O=5;E=0.52;R=9.64;rawP=0.0002;adjP=0.0230"]
["GAA"]
["AMY2B"]
["GUSB"]
["HYAL4"]
["PHKB"]
["cellular component","lysosomal membrane","GO:0005765"]
["C=139;O=5;E=0.61;R=8.22;rawP=0.0004;adjP=0.0396"]
["GAA"]
["AP1B1"]
["OCA2"]
["PNPLA7"]
["ABCA2"]

{"sheet":"S45","index":29,"n_rows":21,"n_cols":3,"rows_kept":21,"cut":false,"hidden":false,"merged":[]}
["S45. HKA KEGG enrichment results - H. sapiens positive selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["KEGG pathway","Starch and sucrose metabolism",500]
["C=54;O=3;E=0.25;R=11.95;rawP=0.0020;adjP=0.0200"]
["GAA"]
["AMY2B"]
["GUSB"]
["KEGG pathway","Lysosome",4142]
["C=121;O=4;E=0.56;R=7.11;rawP=0.0025;adjP=0.0250"]
["GAA"]
["AP1B1"]
["GUSB"]
["ABCA2"]
["KEGG pathway","Glycosaminoglycan degradation",531]
["C=19;O=2;E=0.09;R=22.64;rawP=0.0035;adjP=0.0350"]
["GUSB"]
["HYAL4"]

{"sheet":"S46","index":30,"n_rows":12,"n_cols":3,"rows_kept":12,"cut":false,"hidden":false,"merged":[]}
["S46. HKA GO enrichment results - P. paniscus positive selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["biological process","complement activation","GO:0006956"]
["C=43;O=4;E=0.22;R=17.88;rawP=7.15e-05;adjP=0.0417"]
["C1R"]
["PROS1"]
["CFH"]
["C1RL"]

{"sheet":"S47","index":31,"n_rows":11,"n_cols":3,"rows_kept":11,"cut":false,"hidden":false,"merged":[]}
["S47. HKA KEGG enrichment results - P. paniscus positive selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["KEGG pathway","Complement and coagulation cascades",4610]
["C=69;O=3;E=0.35;R=8.57;rawP=0.0052;adjP=0.0364"]
["C1R"]
["PROS1"]
["CFH"]

{"sheet":"S48","index":32,"n_rows":18,"n_cols":3,"rows_kept":18,"cut":false,"hidden":false,"merged":[]}
["S48. HKA PheWAS enrichment results - P. paniscus positive selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["PheWAS","Abnormal kidney function","PheWAS:589"]
["C=24;O=2;E=0.04;R=47.47;rawP=0.0006;adjP=0.0054"]
["TNFRSF13B"]
["ULK4"]
["PheWAS","Unspecified monoarthritis","PheWAS:716.2"]
["C=31;O=2;E=0.05;R=36.75;rawP=0.0009;adjP=0.0081"]
["CFH"]
["ULK4"]
["PheWAS","First degree AV block","PheWAS:426.21"]
["C=36;O=2;E=0.06;R=31.65;rawP=0.0013;adjP=0.0117"]
["CFH"]
["TNFRSF13B"]

{"sheet":"S49","index":33,"n_rows":11,"n_cols":3,"rows_kept":11,"cut":false,"hidden":false,"merged":[]}
["S49. HKA KEGG enrichment results - P. t. ellioti positive selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["KEGG pathway","Retinol metabolism",830]
["C=64;O=3;E=0.34;R=8.93;rawP=0.0047;adjP=0.0470"]
["CYP3A43"]
["DGAT1"]
["RDH16"]

{"sheet":"S50","index":34,"n_rows":26,"n_cols":3,"rows_kept":26,"cut":false,"hidden":false,"merged":[]}
["S50. HKA GO enrichment results - P.t. troglodytes positive selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["molecular function","enzyme binding","GO:0019899"]
["C=1084;O=18;E=6.44;R=2.80;rawP=5.63e-05;adjP=0.0088"]
["RANBP10"]
["PPP1R35"]
["DOCK3"]
["GSTP1"]
["ADAMTSL4"]
["SUMO1"]
["NIPBL"]
["PIAS1"]
["RABGAP1L"]
["MAP3K11"]
["SP7"]
["ATG13"]
["NCOR1"]
["RELA"]
["PRKAR2A"]
["RAD54L2"]
["FAF1"]
["PKD1"]

{"sheet":"S51","index":35,"n_rows":35,"n_cols":5,"rows_kept":35,"cut":false,"hidden":false,"merged":[]}
["S51. HKA GO enrichment results - P.t. verus positive selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["biological process","glycoside metabolic process","GO:0016137"]
["C=17;O=3;E=0.08;R=35.83;rawP=7.41e-05;adjP=0.0421"]
["GAA"]
["AKR1C2"]
["AKR1C3"]
["molecular function","androsterone dehydrogenase (A-specific) activity","GO:0047026"]
["C=2;O=2;E=0.01;R=197.25;rawP=2.54e-05;adjP=0.0034"]
["AKR1C2"]
["AKR1C3"]
["molecular function","ketosteroid monooxygenase activity","GO:0047086"]
["C=3;O=2;E=0.02;R=131.50;rawP=7.58e-05;adjP=0.0101"]
["AKR1C2"]
["AKR1C3"]
["molecular function","phenanthrene 9","10-monooxygenase activity","GO:0018636"]
["C=3;O=2;E=0.02;R=131.50;rawP=7.58e-05;adjP=0.0101"]
["AKR1C2"]
["AKR1C3"]
["molecular function","trans-1","2-dihydrobenzene-1","2-diol dehydrogenase activity","GO:0047115"]
["C=4;O=2;E=0.02;R=98.62;rawP=0.0002;adjP=0.0266"]
["AKR1C2"]
["AKR1C3"]
["molecular function","prostaglandin F receptor activity","GO:0004958"]
["C=4;O=2;E=0.02;R=98.62;rawP=0.0002;adjP=0.0266"]
["AKR1C2"]
["AKR1C3"]
["molecular function","androsterone dehydrogenase activity","GO:0047023"]
["C=4;O=2;E=0.02;R=98.62;rawP=0.0002;adjP=0.0266"]
["AKR1C2"]
["AKR1C3"]

{"sheet":"S52","index":36,"n_rows":30,"n_cols":3,"rows_kept":30,"cut":false,"hidden":false,"merged":[]}
["S52. HKA KEGG enrichment results - P.t. verus positive selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["KEGG pathway","Metabolism of xenobiotics by cytochrome P450",980]
["C=71;O=5;E=0.40;R=12.60;rawP=4.89e-05;adjP=0.0010"]
["CYP2F1"]
["UGT1A1"]
["AKR1C2"]
["UGT1A9"]
["AKR1C3"]
["KEGG pathway","Steroid hormone biosynthesis",140]
["C=56;O=4;E=0.31;R=12.78;rawP=0.0003;adjP=0.0063"]
["UGT1A1"]
["AKR1C2"]
["UGT1A9"]
["AKR1C3"]
["KEGG pathway","Retinol metabolism",830]
["C=64;O=4;E=0.36;R=11.19;rawP=0.0005;adjP=0.0105"]
["UGT1A1"]
["DHRS4L2"]
["UGT1A9"]
["DHRS4"]
["KEGG pathway","Porphyrin and chlorophyll metabolism",860]
["C=43;O=3;E=0.24;R=12.49;rawP=0.0018;adjP=0.0378"]
["UGT1A1"]
["UGT1A9"]
["COX10"]

{"sheet":"S53","index":37,"n_rows":14,"n_cols":3,"rows_kept":14,"cut":false,"hidden":false,"merged":[]}
["S53. HKA PheWAS enrichment results - P.t. verus positive selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["PheWAS","Rhabdomyolysis","PheWAS:772.4"]
["C=24;O=2;E=0.08;R=23.74;rawP=0.0027;adjP=0.0243"]
["PLEKHM1"]
["UGT1A1"]
["PheWAS","Urticaria","PheWAS:947"]
["C=34;O=2;E=0.12;R=16.75;rawP=0.0055;adjP=0.0495"]
["UGT1A1"]
["KIAA1598"]

{"sheet":"S54","index":38,"n_rows":38,"n_cols":4,"rows_kept":38,"cut":false,"hidden":false,"merged":[]}
["S54. HKA GO enrichment results - P. abelii positive selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["molecular function","protein tyrosine kinase activity","GO:0004713"]
["C=147;O=7;E=0.76;R=9.15;rawP=1.12e-05;adjP=0.0015"]
["ALK"]
["OBSCN"]
["BCR"]
["EPHA3"]
["TTN"]
["MST1R"]
["PEAK1"]
["molecular function","complement receptor activity","complement","GO:0004875"]
["C=3;O=2;E=0.02;R=128.13;rawP=7.99e-05;adjP=0.0107"]
["CR2"]
["CR1"]
["molecular function","structural constituent of muscle",null,"GO:0008307"]
["C=46;O=4;E=0.24;R=16.71;rawP=9.37e-05;adjP=0.0126"]
["OBSCN"]
["TTN"]
["DAG1"]
["NEB"]
["molecular function","protein kinase activity","GO:0004672"]
["C=605;O=11;E=3.15;R=3.49;rawP=0.0003;adjP=0.0402"]
["ALK"]
["BCR"]
["MAP3K3"]
["EPHA3"]
["TTN"]
["CDK8"]
["MST1R"]
["RAF1"]
["OBSCN"]
["TBRG4"]
["PEAK1"]

{"sheet":"S55","index":39,"n_rows":18,"n_cols":3,"rows_kept":18,"cut":false,"hidden":false,"merged":[]}
["S55. HKA GO enrichment results - P. pygmaeus positive selection "]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["molecular function","sulfotransferase activity","GO:0008146"]
["C=51;O=4;E=0.28;R=14.17;rawP=0.0002;adjP=0.0238"]
["GAL3ST2"]
["CHST1"]
["NDST3"]
["TPST1"]
["molecular function","transferase activity, transferring sulfur-containing groups","GO:0016782"]
["C=60;O=4;E=0.33;R=12.04;rawP=0.0003;adjP=0.0357"]
["GAL3ST2"]
["CHST1"]
["NDST3"]
["TPST1"]

{"sheet":"S56","index":40,"n_rows":10,"n_cols":3,"rows_kept":10,"cut":false,"hidden":false,"merged":[]}
["S56. HKA GO enrichment results - Genes with signatures of positive selection in at least 3 lineages"]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed."]
["molecular function","structural molecule activity","GO:0005198"]
["C=621;O=2;E=0.16;R=12.31;rawP=0.0094;adjP=0.0376"]
["NEB"]
["TSGA10"]

{"sheet":"S57","index":41,"n_rows":11,"n_cols":3,"rows_kept":11,"cut":false,"hidden":false,"merged":[]}
["S57. HKA GO enrichment results - H. sapiens balancing selection excluding MHC locus"]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID,"]
["Ensembl Gene Stable ID, Gene symbol, and description."]
["molecular function","magnesium ion transmembrane transporter activity","GO:0015095"]
["C=13;O=2;E=0.02;R=117.57;rawP=0.0001;adjP=0.0034"]
["NIPA2"]
["NIPA1"]

{"sheet":"S58","index":42,"n_rows":66,"n_cols":2,"rows_kept":66,"cut":false,"hidden":false,"merged":[]}
["S58. HKA GO enrichment results – G. gorilla balancing selection excluding MHC locus"]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID,"]
["Ensembl Gene Stable ID, Gene symbol, and description."]
["biological process","detection of chemical stimulus involved in sensory perception of smell"]
["C=37;O=4;E=0.14;R=29.29;rawP=1.00e-05;adjP=0.0030"]
["OR2D2"]
["OR51B4"]
["OR10A5"]
["OR51B6"]
["biological process","sensory perception of smell"]
["C=60;O=4;E=0.22;R=18.06;rawP=6.93e-05;adjP=0.0207"]
["OR2D2"]
["OR51B4"]
["OR10A5"]
["OR51B6"]
["biological process","sensory perception of chemical stimulus"]
["C=117;O=5;E=0.43;R=11.58;rawP=6.94e-05;adjP=0.0207"]
["GNG13"]
["OR2D2"]
["OR51B4"]
["OR10A5"]
["OR51B6"]
["biological process","detection of chemical stimulus involved in sensory perception"]
["C=62;O=4;E=0.23;R=17.48;rawP=7.89e-05;adjP=0.0235"]
["OR2D2"]
["OR51B4"]
["OR10A5"]
["OR51B6"]
["molecular function","olfactory receptor activity"]
["C=419;O=11;E=1.59;R=6.92;rawP=4.12e-07;adjP=3.54e-05"]
["OR5H14"]
["OR10A2"]
["OR52J3"]
["OR52M1"]
["OR51B6"]
["OR4K2"]
["OR10A4"]
["OR5H15"]
["OR51B4"]
["OR2D2"]
["OR10A5"]
["molecular function","ammonium transmembrane transporter activity"]
["C=5;O=2;E=0.02;R=105.41;rawP=0.0001;adjP=0.0086"]
["RHCE"]
["RHD"]
["molecular function","G-protein coupled receptor activity"]
["C=862;O=11;E=3.27;R=3.36;rawP=0.0003;adjP=0.0258"]
["OR5H14"]
["OR10A2"]
["OR52J3"]
["OR52M1"]
["OR51B6"]
["OR4K2"]
["OR10A4"]
["OR5H15"]
["OR51B4"]
["OR2D2"]
["OR10A5"]
["molecular function","cobalamin binding"]
["C=9;O=2;E=0.03;R=58.56;rawP=0.0005;adjP=0.0430"]
["MUT"]
["CD320"]

{"sheet":"S59","index":43,"n_rows":37,"n_cols":2,"rows_kept":37,"cut":false,"hidden":false,"merged":[]}
["S59. HKA GO enrichment results – P. paniscus balancing selection excluding MHC locus"]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID,"]
["Ensembl Gene Stable ID, Gene symbol, and description."]
["molecular function","glycine N-acyltransferase activity"]
["C=4;O=2;E=0.01;R=155.96;rawP=6.02e-05;adjP=0.0045"]
["GLYATL1"]
["GLYATL2"]
["molecular function","G-protein coupled receptor activity"]
["C=862;O=10;E=2.76;R=3.62;rawP=0.0003;adjP=0.0225"]
["NPSR1"]
["OR2M5"]
["OR2M2"]
["OR2T12"]
["OR5H6"]
["GPR179"]
["TSHR"]
["GRM5"]
["LPHN3"]
["OR2M7"]
["molecular function","transmembrane signaling receptor activity"]
["C=1231;O=12;E=3.95;R=3.04;rawP=0.0004;adjP=0.0300"]
["ALK"]
["NPSR1"]
["OR2M5"]
["OR2M2"]
["OR2T12"]
["OR5H6"]
["PTPRN2"]
["GPR179"]
["TSHR"]
["GRM5"]
["LPHN3"]
["OR2M7"]

{"sheet":"S60","index":44,"n_rows":16,"n_cols":2,"rows_kept":16,"cut":false,"hidden":false,"merged":[]}
["S60. HKA GO enrichment results – P.t. ellioti balancing selection excluding MHC locus"]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID,"]
["Ensembl Gene Stable ID, Gene symbol, and description."]
["molecular function","ammonium transmembrane transporter activity"]
["C=5;O=2;E=0.02;R=132.90;rawP=8.81e-05;adjP=0.0079"]
["RHCE"]
["RHD"]
["cellular component","cornified envelope"]
["C=23;O=3;E=0.07;R=40.44;rawP=5.37e-05;adjP=0.0045"]
["SPRR2G"]
["SCEL"]
["SPRR2B"]

{"sheet":"S61","index":45,"n_rows":11,"n_cols":3,"rows_kept":11,"cut":false,"hidden":false,"merged":[]}
["S61. HKA GO enrichment results – P.t. schweinfurthii balancing selection excluding MHC locus"]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID,"]
["Ensembl Gene Stable ID, Gene symbol, and description."]
["molecular function","ammonium transmembrane transporter activity","GO:0008519"]
["C=5;O=2;E=0.01;R=152.84;rawP=6.65e-05;adjP=0.0041"]
["RHCE"]
["RHD"]

{"sheet":"S62","index":46,"n_rows":20,"n_cols":3,"rows_kept":20,"cut":false,"hidden":false,"merged":[]}
["S62. HKA GO enrichment results – P.t. troglodytes balancing selection excluding MHC locus"]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID,"]
["Ensembl Gene Stable ID, Gene symbol, and description."]
["molecular function","glycine N-acyltransferase activity","GO:0047961"]
["C=4;O=2;E=0.01;R=146.96;rawP=6.78e-05;adjP=0.0060"]
["GLYATL1"]
["GLYATL2"]
["molecular function","ammonium transmembrane transporter activity","GO:0008519"]
["C=5;O=2;E=0.02;R=117.57;rawP=0.0001;adjP=0.0088"]
["RHCE"]
["RHD"]
["cellular component","cornified envelope","GO:0001533"]
["C=23;O=3;E=0.08;R=35.31;rawP=8.07e-05;adjP=0.0066"]
["SPRR2G"]
["SCEL"]
["SPRR2B"]

{"sheet":"S63","index":47,"n_rows":32,"n_cols":2,"rows_kept":32,"cut":false,"hidden":false,"merged":[]}
["S63 HKA GO enrichment results – P.t. verus balancing selection excluding MHC locus"]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID,"]
["Ensembl Gene Stable ID, Gene symbol, and description."]
["biological process","keratinization"]
["C=44;O=4;E=0.12;R=32.44;rawP=6.64e-06;adjP=0.0020"]
["SPRR2G"]
["LCE3D"]
["SPRR2B"]
["LCE3E"]
["biological process","keratinocyte differentiation"]
["C=101;O=5;E=0.28;R=17.66;rawP=8.73e-06;adjP=0.0026"]
["SPRR2G"]
["SCEL"]
["LCE3D"]
["SPRR2B"]
["LCE3E"]
["biological process","epidermal cell differentiation"]
["C=121;O=5;E=0.34;R=14.75;rawP=2.10e-05;adjP=0.0063"]
["SPRR2G"]
["SCEL"]
["LCE3D"]
["SPRR2B"]
["LCE3E"]
["cellular component","cornified envelope"]
["C=23;O=3;E=0.06;R=46.34;rawP=3.56e-05;adjP=0.0026"]
["SPRR2G"]
["SCEL"]
["SPRR2B"]

{"sheet":"S64","index":48,"n_rows":161,"n_cols":2,"rows_kept":161,"cut":false,"hidden":false,"merged":[]}
["S64 HKA GO enrichment results – P. abelii balancing selection excluding MHC locus"]
["The results for each enriched GO category are listed in this table. For each GO category, the first row lists its sub-root"]
["(biological process, molecular function, or cellular component), category name, and corresponding GO ID. The second row lists"]
["number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the"]
["category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP)."]
["Finally, genes in the category are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID,"]
["Ensembl Gene Stable ID, Gene symbol, and description."]
["molecular function","olfactory receptor activity"]
["C=419;O=13;E=1.01;R=12.82;rawP=8.05e-12;adjP=4.19e-10"]
["OR10H1"]
["OR10H5"]
["OR1B1"]
["OR11H6"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["OR5AK3P"]
["OR9Q1"]
["OR6Q1"]
["OR11H7"]
["OR4K5"]
["OR11G2"]
["molecular function","G-protein coupled receptor activity"]
["C=862;O=13;E=2.09;R=6.23;rawP=5.37e-08;adjP=2.79e-06"]
["OR10H1"]
["OR10H5"]
["OR1B1"]
["OR11H6"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["OR5AK3P"]
["OR9Q1"]
["OR6Q1"]
["OR11H7"]
["OR4K5"]
["OR11G2"]
["molecular function","transmembrane signaling receptor activity"]
["C=1231;O=13;E=2.98;R=4.36;rawP=3.21e-06;adjP=0.0002"]
["OR10H1"]
["OR10H5"]
["OR1B1"]
["OR11H6"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["OR5AK3P"]
["OR9Q1"]
["OR6Q1"]
["OR11H7"]
["OR4K5"]
["OR11G2"]
["molecular function","receptor activity"]
["C=1531;O=14;E=3.71;R=3.78;rawP=6.39e-06;adjP=0.0003"]
["OR10H1"]
["OR10H5"]
["OR1B1"]
["OR11H6"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["OR5AK3P"]
["OR9Q1"]
["OR6Q1"]
["TNFRSF13B"]
["OR11H7"]
["OR4K5"]
["OR11G2"]
["molecular function","signaling receptor activity"]
["C=1325;O=13;E=3.21;R=4.05;rawP=7.24e-06;adjP=0.0004"]
["OR10H1"]
["OR10H5"]
["OR1B1"]
["OR11H6"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["OR5AK3P"]
["OR9Q1"]
["OR6Q1"]
["OR11H7"]
["OR4K5"]
["OR11G2"]
["molecular function","molecular transducer activity"]
["C=1628;O=13;E=3.94;R=3.30;rawP=6.60e-05;adjP=0.0034"]
["OR10H1"]
["OR10H5"]
["OR1B1"]
["OR11H6"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["OR5AK3P"]
["OR9Q1"]
["OR6Q1"]
["OR11H7"]
["OR4K5"]
["OR11G2"]
["molecular function","signal transducer activity"]
["C=1628;O=13;E=3.94;R=3.30;rawP=6.60e-05;adjP=0.0034"]
["OR10H1"]
["OR10H5"]
["OR1B1"]
["OR11H6"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["OR5AK3P"]
["OR9Q1"]
["OR6Q1"]
["OR11H7"]
["OR4K5"]
["OR11G2"]
["cellular component","plasma membrane"]
["C=4289;O=22;E=10.56;R=2.08;rawP=0.0001;adjP=0.0050"]
["KANK1"]
["KCTD7"]
["OR10H1"]
["DOC2B"]
["OR1B1"]
["PCDH15"]
["PSD3"]
["OR9Q1"]
["TNFRSF13B"]
["OR4K5"]
["OR11H7"]
["XKR3"]
["ABCC6"]
["OR10H5"]
["RAET1L"]
["OR11H6"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["OR5AK3P"]
["OR6Q1"]
["OR11G2"]
["cellular component","cell periphery"]
["C=4377;O=22;E=10.78;R=2.04;rawP=0.0002;adjP=0.0100"]
["KANK1"]
["KCTD7"]
["OR10H1"]
["DOC2B"]
["OR1B1"]
["PCDH15"]
["PSD3"]
["OR9Q1"]
["TNFRSF13B"]
["OR4K5"]
["OR11H7"]
["XKR3"]
["ABCC6"]
["OR10H5"]
["RAET1L"]
["OR11H6"]
["OR4K1"]
["OR4K15"]
["OR1Q1"]
["OR5AK3P"]
["OR6Q1"]
["OR11G2"]

{"sheet":"S65","index":49,"n_rows":25,"n_cols":2,"rows_kept":25,"cut":false,"hidden":false,"merged":[]}
["S65 HKA GO enrichment results – P. pygmaeus balancing selection excluding MHC locus"]
["molecular function","olfactory receptor activity"]
["C=419;O=9;E=1.43;R=6.31;rawP=1.04e-05;adjP=0.0006"]
["OR7C1"]
["OR1B1"]
["OR1Q1"]
["OR4K15"]
["OR2S2"]
["OR7A5"]
["OR1D4"]
["OR13A1"]
["OR4K5"]
["molecular function","G-protein coupled receptor activity"]
["C=862;O=11;E=2.93;R=3.75;rawP=0.0001;adjP=0.0060"]
["EMR2"]
["OR7C1"]
["OR1B1"]
["MCHR2"]
["OR4K15"]
["OR1Q1"]
["OR2S2"]
["OR7A5"]
["OR1D4"]
["OR13A1"]
["OR4K5"]