Annotation Cluster 1 Enrichment Score: 4.817610443893097 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006350~transcription 37 12.416107382550337 4.811992398528973E-7 NM_016734, NM_015001, NM_201559, NM_002198, NM_175709, NM_139135, NM_005270, NM_182972, NM_006763, NM_005524, NM_001018011, NM_020732, NM_001009992, NM_015446, NM_002823, NM_205843, NM_005194, NM_017745, NM_006734, NM_018660, NM_005596, NM_003670, NM_001123384, NM_004176, NM_032199, NM_020908, NM_001455, NM_006769, NM_020680, NM_006186, NM_006312, NM_005994, NM_020310, NM_021724, NM_001206, NM_015335, NM_016270, NM_018717, NM_182557 97 252 1483 2.2447635411552938 5.431265259191465E-4 5.431265259191465E-4 7.72031550777541E-4 SP_PIR_KEYWORDS transcription regulation 36 12.080536912751679 8.042949063005211E-7 NM_016734, NM_015001, NM_201559, NM_002198, NM_175709, NM_139135, NM_005270, NM_182972, NM_006763, NM_005524, NM_001018011, NM_020732, NM_001009992, NM_205843, NM_001131010, NM_005194, NM_017745, NM_006734, NM_018660, NM_005596, NM_003670, NM_001123384, NM_004176, NM_032199, NM_020908, NM_001455, NM_006769, NM_020680, NM_006186, NM_006312, NM_005994, NM_020310, NM_021724, NM_001206, NM_015335, NM_016270, NM_018717, NM_182557 121 252 1955 2.3081463990554902 1.4797937225341506E-4 1.4797937225341506E-4 9.94319754688E-4 SP_PIR_KEYWORDS Transcription 36 12.080536912751679 8.042949063005211E-7 NM_016734, NM_015001, NM_201559, NM_002198, NM_175709, NM_139135, NM_005270, NM_182972, NM_006763, NM_005524, NM_001018011, NM_020732, NM_001009992, NM_205843, NM_001131010, NM_005194, NM_017745, NM_006734, NM_018660, NM_005596, NM_003670, NM_001123384, NM_004176, NM_032199, NM_020908, NM_001455, NM_006769, NM_020680, NM_006186, NM_006312, NM_005994, NM_020310, NM_021724, NM_001206, NM_015335, NM_016270, NM_018717, NM_182557 121 252 1955 2.3081463990554902 1.4797937225341506E-4 1.4797937225341506E-4 9.94319754688E-4 GOTERM_BP_FAT GO:0045449~regulation of transcription 41 13.758389261744966 6.210620794863582E-6 NM_145109, NM_016734, NM_015001, NM_201559, NM_002198, NM_001042572, NM_175709, NM_139135, NM_005270, NM_182972, NM_006763, NM_005524, NM_058246, NM_001018011, NM_020732, NM_001009992, NM_005194, NM_205843, NM_001131010, NM_017745, NM_006734, NM_018660, NM_005596, NM_003670, NM_001123384, NM_004176, NM_032199, NM_020908, NM_001015881, NM_001455, NM_006769, NM_020680, NM_006186, NM_006312, NM_005994, NM_020310, NM_021724, NM_001206, NM_015335, NM_016270, NM_018717, NM_182557, NM_001135592 97 327 1483 1.9169267631388127 0.006987287248940821 0.0034997678118388054 0.00996383238441867 SP_PIR_KEYWORDS dna-binding 31 10.40268456375839 6.37814629774876E-6 NM_016734, NM_015001, NM_201559, NM_003407, NM_001042572, NM_002198, NM_139135, NM_005270, NM_005524, NM_001018011, NM_020732, NM_001009992, NM_015446, NM_205843, NM_001131010, NM_005194, NM_001983, NM_018660, NM_006734, NM_005596, NM_003670, NM_004176, NM_032199, NM_001455, NM_020680, NM_006186, NM_006312, NM_005994, NM_020310, NM_021724, NM_001206, NM_016270 121 216 1955 2.31883226201408 0.0011728942826211286 5.8661920235481E-4 0.00788481437224986 GOTERM_BP_FAT GO:0051252~regulation of RNA metabolic process 34 11.409395973154362 9.916545550950214E-6 NM_145109, NM_016734, NM_015001, NM_003407, NM_201559, NM_001042572, NM_002198, NM_139135, NM_005270, NM_005524, NM_058246, NM_001018011, NM_020732, NM_205843, NM_001131010, NM_005194, NM_017745, NM_018660, NM_006734, NM_005596, NM_003670, NM_001123384, NM_004176, NM_032199, NM_020908, NM_001015881, NM_207292, NM_001455, NM_006186, NM_006312, NM_005994, NM_020310, NM_021724, NM_001206, NM_015335, NM_018717 97 248 1483 2.096025939474559 0.011133395313882577 0.0037249900937289526 0.015908883623128034 GOTERM_MF_FAT GO:0003677~DNA binding 34 11.409395973154362 1.5334499881219506E-5 NM_016734, NM_015001, NM_003407, NM_201559, NM_001042572, NM_002198, NM_139135, NM_005270, NM_005524, NM_058246, NM_001018011, NM_020732, NM_001009992, NM_015446, NM_205843, NM_001131010, NM_005194, NM_001983, NM_006734, NM_018660, NM_005596, NM_003670, NM_004176, NM_032199, NM_001015881, NM_001455, NM_006769, NM_020680, NM_006186, NM_006312, NM_005994, NM_020310, NM_021724, NM_001206, NM_016270 90 264 1425 2.039141414141414 0.0037499326524776944 0.0037499326524776944 0.01985583771303423 SP_PIR_KEYWORDS nucleus 51 17.114093959731544 2.20869445969994E-5 NM_015001, NM_003407, NM_201559, NM_002198, NM_001042572, NM_175709, NM_139135, NM_182972, NM_058246, NM_020732, NM_013275, NM_001009992, NM_014869, NM_205843, NM_133337, NM_005194, NM_004924, NM_017745, NM_018660, NM_006734, NM_005596, NM_207292, NM_020310, NM_016270, NM_018717, NM_182557, NM_001135592, NM_032246, NM_016734, NM_005270, NM_005524, NM_001018011, NM_015446, NM_002823, NM_138705, NM_020695, NM_001131010, NM_025241, NM_001983, NM_003670, NM_001123384, NM_004176, NM_032199, NM_020908, NM_030665, NM_001455, NM_020680, NM_006186, NM_006312, NM_005994, NM_021724, NM_001206, NM_015335 121 486 1955 1.6954902560963168 0.004055795641580318 0.0013537637297592608 0.02730196338077695 GOTERM_MF_FAT GO:0030528~transcription regulator activity 30 10.06711409395973 3.5578105293194374E-5 NM_016734, NM_015001, NM_201559, NM_002198, NM_139135, NM_005270, NM_058246, NM_005524, NM_001018011, NM_020732, NM_205843, NM_001131010, NM_005194, NM_017745, NM_005596, NM_003670, NM_001123384, NM_004176, NM_032199, NM_001015881, NM_001455, NM_006769, NM_006186, NM_006312, NM_005994, NM_020310, NM_021724, NM_001206, NM_015335, NM_016270, NM_018717, NM_001135592 90 225 1425 2.111111111111111 0.008678909786786426 0.004348911408613265 0.0460626465674463 GOTERM_BP_FAT GO:0006355~regulation of transcription, DNA-dependent 32 10.738255033557047 3.614891214719709E-5 NM_145109, NM_016734, NM_015001, NM_201559, NM_001042572, NM_002198, NM_139135, NM_005270, NM_005524, NM_058246, NM_001018011, NM_020732, NM_205843, NM_001131010, NM_005194, NM_017745, NM_018660, NM_006734, NM_005596, NM_003670, NM_001123384, NM_004176, NM_032199, NM_020908, NM_001015881, NM_001455, NM_006186, NM_006312, NM_005994, NM_020310, NM_021724, NM_001206, NM_015335, NM_018717 97 239 1483 2.0470172108872884 0.039991230329819105 0.010151338659982412 0.057981418360186776 GOTERM_MF_FAT GO:0003700~transcription factor activity 20 6.7114093959731544 0.0014403875958827585 NM_005596, NM_015001, NM_016734, NM_003670, NM_201559, NM_002198, NM_004176, NM_005270, NM_001015881, NM_001455, NM_001018011, NM_006769, NM_006186, NM_005994, NM_020310, NM_021724, NM_001206, NM_016270, NM_001131010, NM_005194, NM_205843 90 150 1425 2.111111111111111 0.29752773436013036 0.11105192428164079 1.8492846482970227 GOTERM_BP_FAT GO:0006357~regulation of transcription from RNA polymerase II promoter 19 6.375838926174497 0.00201264196557267 NM_005596, NM_015001, NM_016734, NM_201559, NM_002198, NM_001042572, NM_001123384, NM_004176, NM_005270, NM_005524, NM_001455, NM_006186, NM_006312, NM_005994, NM_001206, NM_015335, NM_001131010, NM_005194, NM_205843, NM_018717, NM_017745 97 137 1483 2.1203250808939726 0.8971581068094014 0.31551855906968085 3.1806480148374616 Annotation Cluster 2 Enrichment Score: 2.392233570345132 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0030528~transcription regulator activity 30 10.06711409395973 3.5578105293194374E-5 NM_016734, NM_015001, NM_201559, NM_002198, NM_139135, NM_005270, NM_058246, NM_005524, NM_001018011, NM_020732, NM_205843, NM_001131010, NM_005194, NM_017745, NM_005596, NM_003670, NM_001123384, NM_004176, NM_032199, NM_001015881, NM_001455, NM_006769, NM_006186, NM_006312, NM_005994, NM_020310, NM_021724, NM_001206, NM_015335, NM_016270, NM_018717, NM_001135592 90 225 1425 2.111111111111111 0.008678909786786426 0.004348911408613265 0.0460626465674463 GOTERM_BP_FAT GO:0006355~regulation of transcription, DNA-dependent 32 10.738255033557047 3.614891214719709E-5 NM_145109, NM_016734, NM_015001, NM_201559, NM_001042572, NM_002198, NM_139135, NM_005270, NM_005524, NM_058246, NM_001018011, NM_020732, NM_205843, NM_001131010, NM_005194, NM_017745, NM_018660, NM_006734, NM_005596, NM_003670, NM_001123384, NM_004176, NM_032199, NM_020908, NM_001015881, NM_001455, NM_006186, NM_006312, NM_005994, NM_020310, NM_021724, NM_001206, NM_015335, NM_018717 97 239 1483 2.0470172108872884 0.039991230329819105 0.010151338659982412 0.057981418360186776 GOTERM_BP_FAT GO:0051253~negative regulation of RNA metabolic process 13 4.3624161073825505 0.0018250129183220265 NM_015001, NM_016734, NM_003670, NM_001123384, NM_032199, NM_005270, NM_005524, NM_058246, NM_001018011, NM_006312, NM_005994, NM_001131010, NM_205843, NM_017745 97 73 1483 2.722638045473803 0.8728416399670041 0.337983241214851 2.8881902382728364 GOTERM_BP_FAT GO:0045892~negative regulation of transcription, DNA-dependent 13 4.3624161073825505 0.0018250129183220265 NM_015001, NM_016734, NM_003670, NM_001123384, NM_032199, NM_005270, NM_005524, NM_058246, NM_001018011, NM_006312, NM_005994, NM_001131010, NM_205843, NM_017745 97 73 1483 2.722638045473803 0.8728416399670041 0.337983241214851 2.8881902382728364 GOTERM_BP_FAT GO:0006357~regulation of transcription from RNA polymerase II promoter 19 6.375838926174497 0.00201264196557267 NM_005596, NM_015001, NM_016734, NM_201559, NM_002198, NM_001042572, NM_001123384, NM_004176, NM_005270, NM_005524, NM_001455, NM_006186, NM_006312, NM_005994, NM_001206, NM_015335, NM_001131010, NM_005194, NM_205843, NM_018717, NM_017745 97 137 1483 2.1203250808939726 0.8971581068094014 0.31551855906968085 3.1806480148374616 GOTERM_BP_FAT GO:0045934~negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 14 4.697986577181208 0.00433018833088308 NM_015001, NM_016734, NM_003670, NM_001123384, NM_032199, NM_005270, NM_005524, NM_058246, NM_001018011, NM_006312, NM_005994, NM_001131010, NM_205843, NM_017745, NM_001983 97 91 1483 2.352101506740682 0.9925489324059424 0.45796502193807476 6.725575729455602 GOTERM_BP_FAT GO:0051172~negative regulation of nitrogen compound metabolic process 14 4.697986577181208 0.004773549152744718 NM_015001, NM_016734, NM_003670, NM_001123384, NM_032199, NM_005270, NM_005524, NM_058246, NM_001018011, NM_006312, NM_005994, NM_001131010, NM_205843, NM_017745, NM_001983 97 92 1483 2.3265351860152395 0.9954935303210446 0.45132501368900113 7.3897196254412485 GOTERM_BP_FAT GO:0016481~negative regulation of transcription 13 4.3624161073825505 0.00744318260573715 NM_015001, NM_016734, NM_003670, NM_001123384, NM_032199, NM_005270, NM_005524, NM_058246, NM_001018011, NM_006312, NM_005994, NM_001131010, NM_205843, NM_017745 97 86 1483 2.311076480460321 0.9997828197847455 0.5355022015571955 11.295964322851471 GOTERM_MF_FAT GO:0016564~transcription repressor activity 11 3.691275167785235 0.008596976851926246 NM_015001, NM_006312, NM_005994, NM_020310, NM_003670, NM_021724, NM_001123384, NM_032199, NM_017745, NM_058246, NM_005524, NM_001018011 90 69 1425 2.5241545893719803 0.8794107681442432 0.34496922345167935 10.578517412469491 GOTERM_BP_FAT GO:0010629~negative regulation of gene expression 13 4.3624161073825505 0.009803449681210679 NM_015001, NM_016734, NM_003670, NM_001123384, NM_032199, NM_005270, NM_005524, NM_058246, NM_001018011, NM_006312, NM_005994, NM_001131010, NM_205843, NM_017745 97 89 1483 2.2331750260627823 0.9999852269302847 0.5749687848197381 14.62033659923202 GOTERM_BP_FAT GO:0010558~negative regulation of macromolecule biosynthetic process 13 4.3624161073825505 0.01899289283185518 NM_015001, NM_016734, NM_003670, NM_001123384, NM_032199, NM_005270, NM_005524, NM_058246, NM_001018011, NM_006312, NM_005994, NM_001131010, NM_205843, NM_017745 97 97 1483 2.0489956424699756 0.9999999996038482 0.6799995346375503 26.48290602495941 GOTERM_BP_FAT GO:0031327~negative regulation of cellular biosynthetic process 13 4.3624161073825505 0.02048967134478495 NM_015001, NM_016734, NM_003670, NM_001123384, NM_032199, NM_005270, NM_005524, NM_058246, NM_001018011, NM_006312, NM_005994, NM_001131010, NM_205843, NM_017745 97 98 1483 2.0280875236692615 0.9999999999293384 0.6714300949238996 28.262037909081894 GOTERM_BP_FAT GO:0010605~negative regulation of macromolecule metabolic process 15 5.033557046979865 0.021390825549320827 NM_015001, NM_016734, NM_003670, NM_001123384, NM_032199, NM_005270, NM_005524, NM_058246, NM_001018011, NM_006312, NM_005994, NM_001131010, NM_205843, NM_017745, NM_001983, NM_001135592 97 122 1483 1.8797532533378403 0.9999999999750034 0.6703254098228114 29.313631508230475 GOTERM_BP_FAT GO:0009890~negative regulation of biosynthetic process 13 4.3624161073825505 0.02551327613925513 NM_015001, NM_016734, NM_003670, NM_001123384, NM_032199, NM_005270, NM_005524, NM_058246, NM_001018011, NM_006312, NM_005994, NM_001131010, NM_205843, NM_017745 97 101 1483 1.967847300193937 0.9999999999997872 0.6887417627192227 33.94261620643265 GOTERM_BP_FAT GO:0000122~negative regulation of transcription from RNA polymerase II promoter 8 2.684563758389262 0.05507678252275978 NM_006312, NM_016734, NM_005994, NM_001123384, NM_205843, NM_001131010, NM_017745, NM_005270, NM_005524 97 54 1483 2.2649866361206565 1.0 0.8391718623605102 59.70393439380213 Annotation Cluster 3 Enrichment Score: 2.066854507768333 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0030528~transcription regulator activity 30 10.06711409395973 3.5578105293194374E-5 NM_016734, NM_015001, NM_201559, NM_002198, NM_139135, NM_005270, NM_058246, NM_005524, NM_001018011, NM_020732, NM_205843, NM_001131010, NM_005194, NM_017745, NM_005596, NM_003670, NM_001123384, NM_004176, NM_032199, NM_001015881, NM_001455, NM_006769, NM_006186, NM_006312, NM_005994, NM_020310, NM_021724, NM_001206, NM_015335, NM_016270, NM_018717, NM_001135592 90 225 1425 2.111111111111111 0.008678909786786426 0.004348911408613265 0.0460626465674463 GOTERM_MF_FAT GO:0003700~transcription factor activity 20 6.7114093959731544 0.0014403875958827585 NM_005596, NM_015001, NM_016734, NM_003670, NM_201559, NM_002198, NM_004176, NM_005270, NM_001015881, NM_001455, NM_001018011, NM_006769, NM_006186, NM_005994, NM_020310, NM_021724, NM_001206, NM_016270, NM_001131010, NM_005194, NM_205843 90 150 1425 2.111111111111111 0.29752773436013036 0.11105192428164079 1.8492846482970227 GOTERM_BP_FAT GO:0006357~regulation of transcription from RNA polymerase II promoter 19 6.375838926174497 0.00201264196557267 NM_005596, NM_015001, NM_016734, NM_201559, NM_002198, NM_001042572, NM_001123384, NM_004176, NM_005270, NM_005524, NM_001455, NM_006186, NM_006312, NM_005994, NM_001206, NM_015335, NM_001131010, NM_005194, NM_205843, NM_018717, NM_017745 97 137 1483 2.1203250808939726 0.8971581068094014 0.31551855906968085 3.1806480148374616 GOTERM_BP_FAT GO:0045941~positive regulation of transcription 15 5.033557046979865 0.003361567762231579 NM_145109, NM_005596, NM_201559, NM_002198, NM_139135, NM_004176, NM_005270, NM_005524, NM_001455, NM_006186, NM_020732, NM_005194, NM_205843, NM_016270, NM_018717, NM_001135592 97 99 1483 2.316463605123399 0.9776650656376625 0.41904744153123397 5.2590372496146625 GOTERM_MF_FAT GO:0016563~transcription activator activity 11 3.691275167785235 0.005577935766821636 NM_005596, NM_006186, NM_015001, NM_020732, NM_020310, NM_201559, NM_139135, NM_005194, NM_016270, NM_018717, NM_005270, NM_001455 90 65 1425 2.6794871794871793 0.7459997132570395 0.29008140522291703 6.987340778378048 GOTERM_BP_FAT GO:0010628~positive regulation of gene expression 15 5.033557046979865 0.006368466666370394 NM_145109, NM_005596, NM_201559, NM_002198, NM_139135, NM_004176, NM_005270, NM_005524, NM_001455, NM_006186, NM_020732, NM_005194, NM_205843, NM_016270, NM_018717, NM_001135592 97 106 1483 2.163489593464307 0.999263050485527 0.5138796815776562 9.742382744933343 GOTERM_BP_FAT GO:0010557~positive regulation of macromolecule biosynthetic process 16 5.369127516778524 0.008637505183149187 NM_145109, NM_005596, NM_005544, NM_201559, NM_002198, NM_139135, NM_004176, NM_005270, NM_005524, NM_001455, NM_006186, NM_020732, NM_016270, NM_005194, NM_205843, NM_018717, NM_001135592 97 121 1483 2.02164096447133 0.9999442204261199 0.5578805721256326 12.993015247409767 GOTERM_BP_FAT GO:0045893~positive regulation of transcription, DNA-dependent 13 4.3624161073825505 0.009803449681210679 NM_145109, NM_005596, NM_201559, NM_002198, NM_139135, NM_004176, NM_005270, NM_005524, NM_001455, NM_020732, NM_006186, NM_005194, NM_205843, NM_018717 97 89 1483 2.2331750260627823 0.9999852269302847 0.5749687848197381 14.62033659923202 GOTERM_BP_FAT GO:0051254~positive regulation of RNA metabolic process 13 4.3624161073825505 0.01070845924391304 NM_145109, NM_005596, NM_201559, NM_002198, NM_139135, NM_004176, NM_005270, NM_005524, NM_001455, NM_020732, NM_006186, NM_005194, NM_205843, NM_018717 97 90 1483 2.20836197021764 0.9999947382568265 0.580301099112309 15.863747541440754 GOTERM_BP_FAT GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 15 5.033557046979865 0.011248284608290695 NM_145109, NM_005596, NM_201559, NM_002198, NM_139135, NM_004176, NM_005270, NM_005524, NM_001455, NM_006186, NM_020732, NM_005194, NM_205843, NM_016270, NM_018717, NM_001135592 97 113 1483 2.029468114223155 0.999997158777715 0.5731908898007587 16.59731857379786 GOTERM_BP_FAT GO:0031328~positive regulation of cellular biosynthetic process 16 5.369127516778524 0.015412156161621532 NM_145109, NM_005596, NM_005544, NM_201559, NM_002198, NM_139135, NM_004176, NM_005270, NM_005524, NM_001455, NM_006186, NM_020732, NM_016270, NM_005194, NM_205843, NM_018717, NM_001135592 97 129 1483 1.8962678814033407 0.9999999757732009 0.6657907218399224 22.05738925270977 GOTERM_BP_FAT GO:0051173~positive regulation of nitrogen compound metabolic process 15 5.033557046979865 0.018690523740752845 NM_145109, NM_005596, NM_201559, NM_002198, NM_139135, NM_004176, NM_005270, NM_005524, NM_001455, NM_006186, NM_020732, NM_005194, NM_205843, NM_016270, NM_018717, NM_001135592 97 120 1483 1.911082474226804 0.9999999994389962 0.7143583601303487 26.1185110025686 GOTERM_BP_FAT GO:0009891~positive regulation of biosynthetic process 16 5.369127516778524 0.01882196894102061 NM_145109, NM_005596, NM_005544, NM_201559, NM_002198, NM_139135, NM_004176, NM_005270, NM_005524, NM_001455, NM_006186, NM_020732, NM_016270, NM_005194, NM_205843, NM_018717, NM_001135592 97 132 1483 1.8531708840987193 0.9999999995177371 0.6963280641442471 26.27712756873204 GOTERM_BP_FAT GO:0045944~positive regulation of transcription from RNA polymerase II promoter 10 3.3557046979865772 0.030052928313033703 NM_005596, NM_006186, NM_201559, NM_002198, NM_205843, NM_005194, NM_004176, NM_018717, NM_005270, NM_005524, NM_001455 97 69 1483 2.2157477962049903 0.9999999999999989 0.7208281729983064 38.710515924274326 SP_PIR_KEYWORDS activator 11 3.691275167785235 0.051402921455188724 NM_020680, NM_005596, NM_201559, NM_002198, NM_015335, NM_205843, NM_005194, NM_016270, NM_004176, NM_018717, NM_182557, NM_001455 121 92 1955 1.9318181818181819 0.9999393196560249 0.6600228087952413 47.92019550076444 GOTERM_BP_FAT GO:0010604~positive regulation of macromolecule metabolic process 16 5.369127516778524 0.052709196030139384 NM_145109, NM_005596, NM_005544, NM_201559, NM_002198, NM_139135, NM_004176, NM_005270, NM_005524, NM_001455, NM_006186, NM_020732, NM_016270, NM_005194, NM_205843, NM_018717, NM_001135592 97 150 1483 1.6307903780068729 1.0 0.8343818480119802 58.05316038536077 GOTERM_MF_FAT GO:0043565~sequence-specific DNA binding 10 3.3557046979865772 0.13167488635368735 NM_006186, NM_005994, NM_021724, NM_201559, NM_002198, NM_005194, NM_004176, NM_001131010, NM_005270, NM_001983, NM_001455 90 95 1425 1.6666666666666665 0.999999999999999 0.9569186832907897 83.93216389508665 Annotation Cluster 4 Enrichment Score: 1.3326633330712048 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS DNA binding 9 3.0201342281879198 0.005033915353906288 NM_016734, NM_003407, NM_002198, NM_205843, NM_005194, NM_001131010, NM_005270, NM_001983, NM_006734 121 45 1955 3.231404958677686 0.604885461987766 0.1694905051413481 6.048346885739619 GOTERM_BP_FAT GO:0006366~transcription from RNA polymerase II promoter 6 2.013422818791946 0.06380507297016831 NM_006769, NM_016734, NM_020310, NM_002198, NM_205843, NM_005194 97 34 1483 2.697998787143723 1.0 0.8662527983864733 65.2782446385358 GOTERM_BP_FAT GO:0006351~transcription, DNA-dependent 6 2.013422818791946 0.11149612802252487 NM_006769, NM_016734, NM_020310, NM_002198, NM_205843, NM_005194 97 40 1483 2.2932989690721652 1.0 0.9379953109309185 84.99306379847036 GOTERM_BP_FAT GO:0032774~RNA biosynthetic process 6 2.013422818791946 0.13041446490494962 NM_006769, NM_016734, NM_020310, NM_002198, NM_205843, NM_005194 97 42 1483 2.184094256259205 1.0 0.9518743266780595 89.37500299308127 Annotation Cluster 5 Enrichment Score: 1.2925889590416455 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0031981~nuclear lumen 16 5.369127516778524 0.00802455730582588 NM_022748, NM_005596, NM_015001, NM_139135, NM_001018011, NM_006769, NM_006312, NM_020732, NM_005994, NM_015446, NM_015335, NM_005194, NM_018717, NM_004924, NM_001983, NM_001135592 72 147 1332 2.0136054421768708 0.8051560412927545 0.8051560412927545 9.627611933112966 GOTERM_CC_FAT GO:0070013~intracellular organelle lumen 17 5.704697986577181 0.018376159374465063 NM_022748, NM_005596, NM_015001, NM_017446, NM_139135, NM_001018011, NM_006769, NM_006312, NM_020732, NM_005994, NM_015446, NM_015335, NM_005194, NM_018717, NM_004924, NM_001983, NM_001135592 72 176 1332 1.7869318181818183 0.9768338002046868 0.8477955329324622 20.7874426393579 GOTERM_CC_FAT GO:0043233~organelle lumen 17 5.704697986577181 0.031334641104087874 NM_022748, NM_005596, NM_015001, NM_017446, NM_139135, NM_001018011, NM_006769, NM_006312, NM_020732, NM_005994, NM_015446, NM_015335, NM_005194, NM_018717, NM_004924, NM_001983, NM_001135592 72 187 1332 1.6818181818181819 0.9984394593380259 0.884008803135989 32.96832470876725 GOTERM_CC_FAT GO:0031974~membrane-enclosed lumen 17 5.704697986577181 0.034291059893287866 NM_022748, NM_005596, NM_015001, NM_017446, NM_139135, NM_001018011, NM_006769, NM_006312, NM_020732, NM_005994, NM_015446, NM_015335, NM_005194, NM_018717, NM_004924, NM_001983, NM_001135592 72 189 1332 1.664021164021164 0.9991609474881753 0.8298048086563646 35.49394791412256 GOTERM_CC_FAT GO:0005730~nucleolus 8 2.684563758389262 0.07818079751553025 NM_022748, NM_005596, NM_015001, NM_020732, NM_006312, NM_139135, NM_004924, NM_001018011 72 71 1332 2.084507042253521 0.9999999334592958 0.8732681063855927 64.04238268517459 GOTERM_CC_FAT GO:0005654~nucleoplasm 9 3.0201342281879198 0.0900927609789949 NM_006769, NM_006312, NM_005994, NM_015446, NM_015335, NM_018717, NM_001983, NM_001135592, NM_001018011 72 88 1332 1.8920454545454546 0.9999999952530418 0.8811067314466171 69.46354714378431 GOTERM_CC_FAT GO:0043228~non-membrane-bounded organelle 22 7.38255033557047 0.09099374105388622 NM_022748, NM_005596, NM_015001, NM_173352, NM_020979, NM_017446, NM_001042572, NM_175709, NM_139135, NM_003370, NM_004523, NM_001018011, NM_020680, NM_006312, NM_020732, NM_004649, NM_015446, NM_133337, NM_025241, NM_004924, NM_001983, NM_001135592 72 298 1332 1.3657718120805369 0.999999996117823 0.8558191660266906 69.84129105076374 GOTERM_CC_FAT GO:0043232~intracellular non-membrane-bounded organelle 22 7.38255033557047 0.09099374105388622 NM_022748, NM_005596, NM_015001, NM_173352, NM_020979, NM_017446, NM_001042572, NM_175709, NM_139135, NM_003370, NM_004523, NM_001018011, NM_020680, NM_006312, NM_020732, NM_004649, NM_015446, NM_133337, NM_025241, NM_004924, NM_001983, NM_001135592 72 298 1332 1.3657718120805369 0.999999996117823 0.8558191660266906 69.84129105076374 GOTERM_CC_FAT GO:0044451~nucleoplasm part 6 2.013422818791946 0.2517705155501154 NM_006769, NM_006312, NM_005994, NM_015335, NM_018717, NM_001018011 72 64 1332 1.734375 1.0 0.9473433287630243 97.38598407575782 Annotation Cluster 6 Enrichment Score: 1.266127767985198 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0046394~carboxylic acid biosynthetic process 5 1.6778523489932886 0.020430119079863685 NM_001130721, NM_004104, NM_012205, NM_001956, NM_021814 97 17 1483 4.496664645239538 0.999999999924318 0.6881472018971253 28.19202975761097 GOTERM_BP_FAT GO:0016053~organic acid biosynthetic process 5 1.6778523489932886 0.020430119079863685 NM_001130721, NM_004104, NM_012205, NM_001956, NM_021814 97 17 1483 4.496664645239538 0.999999999924318 0.6881472018971253 28.19202975761097 GOTERM_BP_FAT GO:0006633~fatty acid biosynthetic process 4 1.342281879194631 0.0377161352764888 NM_001130721, NM_004104, NM_001956, NM_021814 97 12 1483 5.096219931271477 1.0 0.7646880944469988 46.03437688833941 SP_PIR_KEYWORDS Fatty acid biosynthesis 3 1.006711409395973 0.047628039650633926 NM_001130721, NM_004104, NM_021814 121 6 1955 8.078512396694215 0.9998739872512883 0.6744993871322034 45.299320734232154 GOTERM_BP_FAT GO:0006631~fatty acid metabolic process 4 1.342281879194631 0.07963682894984783 NM_001130721, NM_004104, NM_001956, NM_021814 97 16 1483 3.8221649484536084 1.0 0.8925541056575966 73.59031634732193 SP_PIR_KEYWORDS lipid synthesis 3 1.006711409395973 0.14308411778163443 NM_001130721, NM_004104, NM_021814 121 11 1955 4.406461307287754 0.9999999999995423 0.8685936839187381 85.1769993634191 GOTERM_BP_FAT GO:0008610~lipid biosynthetic process 5 1.6778523489932886 0.160497602075736 NM_001130721, NM_004104, NM_032047, NM_001956, NM_021814 97 33 1483 2.316463605123399 1.0 0.9628168490732893 93.96036449686396 Annotation Cluster 7 Enrichment Score: 1.2553868781843096 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:ARID 3 1.006711409395973 0.047628039650633926 NM_020732, NM_139135, NM_032199 121 6 1955 8.078512396694215 0.9999999997833245 0.9883275516173469 50.024063590880765 INTERPRO IPR001606:AT-rich interaction region 3 1.006711409395973 0.05544270762455718 NM_020732, NM_139135, NM_032199 119 6 1769 7.432773109243698 0.9999999534865696 0.9999999534865696 53.263847825228325 SMART SM00501:BRIGHT 3 1.006711409395973 0.06488319500248937 NM_020732, NM_139135, NM_032199 82 6 1112 6.780487804878048 0.9966611396774565 0.9966611396774565 51.409239580801305 Annotation Cluster 8 Enrichment Score: 1.1504294810063016 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016564~transcription repressor activity 11 3.691275167785235 0.008596976851926246 NM_015001, NM_006312, NM_005994, NM_020310, NM_003670, NM_021724, NM_001123384, NM_032199, NM_017745, NM_058246, NM_005524, NM_001018011 90 69 1425 2.5241545893719803 0.8794107681442432 0.34496922345167935 10.578517412469491 SP_PIR_KEYWORDS repressor 11 3.691275167785235 0.011913622772988972 NM_015001, NM_006312, NM_020310, NM_021724, NM_001123384, NM_175709, NM_015335, NM_001131010, NM_017745, NM_020908, NM_182972, NM_005524 121 73 1955 2.4346201743462017 0.8897791504861596 0.30756774137555476 13.771438053557095 GOTERM_MF_FAT GO:0003712~transcription cofactor activity 7 2.348993288590604 0.12322208992479465 NM_015001, NM_020732, NM_006312, NM_020310, NM_021724, NM_001123384, NM_018717, NM_017745 90 55 1425 2.015151515151515 0.9999999999999898 0.9721177391636476 81.78455888399083 GOTERM_MF_FAT GO:0003714~transcription corepressor activity 5 1.6778523489932886 0.13445357715690606 NM_015001, NM_006312, NM_020310, NM_021724, NM_001123384, NM_017745 90 32 1425 2.4739583333333335 0.9999999999999996 0.947558113919811 84.58542633901148 GOTERM_MF_FAT GO:0008134~transcription factor binding 8 2.684563758389262 0.15693960867201492 NM_006769, NM_015001, NM_020732, NM_006312, NM_020310, NM_021724, NM_001123384, NM_018717, NM_017745 90 72 1425 1.7592592592592593 1.0 0.9599390369508788 89.03786517129278 GOTERM_MF_FAT GO:0003713~transcription coactivator activity 3 1.006711409395973 0.4699374055955661 NM_020732, NM_020310, NM_018717 90 25 1425 1.9000000000000001 1.0 0.9997212138164521 99.97307657909616 Annotation Cluster 9 Enrichment Score: 1.0050709818767436 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048667~cell morphogenesis involved in neuron differentiation 7 2.348993288590604 0.028452741988534955 NM_006186, NM_020796, NM_005270, NM_001627, NM_005524, NM_003370, NM_001135592 97 37 1483 2.8924491501811085 0.999999999999993 0.7144742468906207 37.06796923521245 GOTERM_BP_FAT GO:0030182~neuron differentiation 10 3.3557046979865772 0.032674945090411876 NM_006186, NM_020796, NM_005194, NM_005270, NM_001627, NM_003827, NM_006763, NM_005524, NM_003370, NM_001135592 97 70 1483 2.1840942562592045 1.0 0.7380248871190562 41.315327078124476 GOTERM_BP_FAT GO:0007411~axon guidance 5 1.6778523489932886 0.04212167314054309 NM_020796, NM_005270, NM_001627, NM_003370, NM_001135592 97 21 1483 3.640157093765341 1.0 0.7913901103398221 49.864670621810035 GOTERM_BP_FAT GO:0032989~cellular component morphogenesis 9 3.0201342281879198 0.06262670962906923 NM_006186, NM_020796, NM_001769, NM_002211, NM_005270, NM_001627, NM_005524, NM_003370, NM_001135592 97 67 1483 2.0537005693183565 1.0 0.8684329525221836 64.57039203484852 GOTERM_BP_FAT GO:0007409~axonogenesis 6 2.013422818791946 0.06380507297016831 NM_006186, NM_020796, NM_005270, NM_001627, NM_003370, NM_001135592 97 34 1483 2.697998787143723 1.0 0.8662527983864733 65.2782446385358 GOTERM_BP_FAT GO:0006928~cell motion 11 3.691275167785235 0.06764205417486606 NM_022748, NM_006186, NM_020796, NM_001769, NM_002211, NM_032199, NM_005270, NM_001627, NM_003370, NM_001956, NM_001135592 97 92 1483 1.827991931869117 1.0 0.8683389006233271 67.49235235262486 GOTERM_BP_FAT GO:0000904~cell morphogenesis involved in differentiation 7 2.348993288590604 0.09908824112045142 NM_006186, NM_020796, NM_005270, NM_001627, NM_005524, NM_003370, NM_001135592 97 50 1483 2.1404123711340204 1.0 0.9312634274474062 81.25334781074038 GOTERM_BP_FAT GO:0048812~neuron projection morphogenesis 6 2.013422818791946 0.10258007196069398 NM_006186, NM_020796, NM_005270, NM_001627, NM_003370, NM_001135592 97 39 1483 2.352101506740682 1.0 0.9297977210100979 82.38572249550897 GOTERM_BP_FAT GO:0048858~cell projection morphogenesis 6 2.013422818791946 0.12077810830687219 NM_006186, NM_020796, NM_005270, NM_001627, NM_003370, NM_001135592 97 41 1483 2.237364847875283 1.0 0.9453306421783609 87.32003033022919 GOTERM_BP_FAT GO:0032990~cell part morphogenesis 6 2.013422818791946 0.13041446490494962 NM_006186, NM_020796, NM_005270, NM_001627, NM_003370, NM_001135592 97 42 1483 2.184094256259205 1.0 0.9518743266780595 89.37500299308127 GOTERM_BP_FAT GO:0048666~neuron development 7 2.348993288590604 0.13118977781333194 NM_006186, NM_020796, NM_005270, NM_001627, NM_005524, NM_003370, NM_001135592 97 54 1483 1.9818633066055744 1.0 0.9499982039876336 89.52597450411524 GOTERM_BP_FAT GO:0031175~neuron projection development 6 2.013422818791946 0.14039257621520412 NM_006186, NM_020796, NM_005270, NM_001627, NM_003370, NM_001135592 97 43 1483 2.1333013665787584 1.0 0.9526364499203526 91.17094811401742 GOTERM_BP_FAT GO:0000902~cell morphogenesis 7 2.348993288590604 0.22941097813054945 NM_006186, NM_020796, NM_005270, NM_001627, NM_005524, NM_003370, NM_001135592 97 64 1483 1.6721971649484535 1.0 0.9850509453596548 98.47176789309442 GOTERM_BP_FAT GO:0030030~cell projection organization 6 2.013422818791946 0.33359850262339286 NM_006186, NM_020796, NM_005270, NM_001627, NM_003370, NM_001135592 97 59 1483 1.5547789620828236 1.0 0.9957250855879615 99.85139750765495 GOTERM_CC_FAT GO:0042995~cell projection 8 2.684563758389262 0.35138040468931653 NM_020796, NM_020979, NM_001025101, NM_002211, NM_004924, NM_005270, NM_001627, NM_003370 72 108 1332 1.3703703703703702 1.0 0.9702587425010889 99.56574400022957 Annotation Cluster 10 Enrichment Score: 0.9492110236684 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045596~negative regulation of cell differentiation 6 2.013422818791946 0.03512448589925567 NM_003407, NM_001025101, NM_002211, NM_005270, NM_005524, NM_001018011 97 29 1483 3.163170991823676 1.0 0.7514286482881389 43.654679250158246 GOTERM_BP_FAT GO:0051960~regulation of nervous system development 5 1.6778523489932886 0.06451016462204082 NM_001025101, NM_005270, NM_005524, NM_001135592, NM_012401 97 24 1483 3.1851374570446733 1.0 0.8621027464781166 65.69543475684122 GOTERM_BP_FAT GO:0045664~regulation of neuron differentiation 4 1.342281879194631 0.09232398106481593 NM_001025101, NM_005270, NM_005524, NM_012401 97 17 1483 3.597331716191631 1.0 0.9213967462232513 78.86295655416322 GOTERM_BP_FAT GO:0060284~regulation of cell development 5 1.6778523489932886 0.10223953145049439 NM_001025101, NM_005270, NM_005524, NM_001135592, NM_012401 97 28 1483 2.7301178203240055 1.0 0.9331889284140883 82.27817763722852 GOTERM_BP_FAT GO:0050767~regulation of neurogenesis 4 1.342281879194631 0.13482886471035355 NM_001025101, NM_005270, NM_005524, NM_012401 97 20 1483 3.057731958762887 1.0 0.9488464187234505 90.20809757249006 GOTERM_BP_FAT GO:0007267~cell-cell signaling 5 1.6778523489932886 0.6994867301859462 NM_021954, NM_001025101, NM_005270, NM_001135592, NM_001097642 97 72 1483 1.0617124856815578 1.0 0.9999570074627147 99.99999958037333 Annotation Cluster 11 Enrichment Score: 0.9191509065499123 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS chromatin regulator 5 1.6778523489932886 0.07075695514813365 NM_020732, NM_001123384, NM_175709, NM_139135, NM_001131010, NM_017745 121 26 1955 3.107120152574698 0.9999986329174744 0.7069846107715231 59.6361228619992 GOTERM_BP_FAT GO:0051276~chromosome organization 7 2.348993288590604 0.07178757189237975 NM_020732, NM_001042572, NM_001123384, NM_175709, NM_139135, NM_001131010, NM_017745, NM_001983 97 46 1483 2.3265351860152395 1.0 0.8714360253451237 69.7353467670801 GOTERM_BP_FAT GO:0006325~chromatin organization 6 2.013422818791946 0.12077810830687219 NM_020732, NM_001042572, NM_001123384, NM_175709, NM_139135, NM_001131010, NM_017745 97 41 1483 2.237364847875283 1.0 0.9453306421783609 87.32003033022919 GOTERM_BP_FAT GO:0016568~chromatin modification 4 1.342281879194631 0.34323356454324394 NM_020732, NM_001123384, NM_175709, NM_139135, NM_017745 97 32 1483 1.9110824742268042 1.0 0.9962434619588569 99.88236195834712 Annotation Cluster 12 Enrichment Score: 0.9141309343533484 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR011598:Helix-loop-helix DNA-binding 4 1.342281879194631 0.06134677139093613 NM_020310, NM_003670, NM_004176, NM_005524 119 14 1769 4.247298919567827 0.9999999927300274 0.9999147358654967 57.012890713435624 UP_SEQ_FEATURE DNA-binding region:Basic motif 5 1.6778523489932886 0.11810601454125962 NM_020310, NM_003670, NM_005194, NM_004176, NM_005524 121 31 1955 2.605971740869102 1.0 0.9967567012065409 83.24445590892559 UP_SEQ_FEATURE domain:Helix-loop-helix motif 4 1.342281879194631 0.12002850794587758 NM_020310, NM_003670, NM_004176, NM_005524 121 20 1955 3.2314049586776856 1.0 0.9950114862930796 83.75622389480615 INTERPRO IPR001092:Basic helix-loop-helix dimerisation region bHLH 4 1.342281879194631 0.16050238284785234 NM_020310, NM_003670, NM_004176, NM_005524 119 21 1769 2.831532613045218 1.0 0.9999976152623156 90.3005077380905 SMART SM00353:HLH 4 1.342281879194631 0.19253766938212868 NM_020310, NM_003670, NM_004176, NM_005524 82 21 1112 2.583042973286876 0.999999987253439 0.9998870993309099 89.98263122644421 Annotation Cluster 13 Enrichment Score: 0.8636189411902649 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005739~mitochondrion 10 3.3557046979865772 0.06665853037385203 NM_001654, NM_004649, NM_001126122, NM_017446, NM_001130721, NM_178006, NM_001127242, NM_001015881, NM_012205, NM_001143780 72 97 1332 1.907216494845361 0.9999991716112401 0.9392359322200744 57.96857488499594 GOTERM_CC_FAT GO:0031967~organelle envelope 7 2.348993288590604 0.07257032677765156 NM_015446, NM_001126122, NM_001127242, NM_004176, NM_133337, NM_012205, NM_001143780 72 56 1332 2.3125 0.9999997719445904 0.9218360083394382 61.19377651667573 GOTERM_CC_FAT GO:0031975~envelope 7 2.348993288590604 0.07779301976243255 NM_015446, NM_001126122, NM_001127242, NM_004176, NM_133337, NM_012205, NM_001143780 72 57 1332 2.2719298245614037 0.9999999275286695 0.9044955192340687 63.851867091846 SP_PIR_KEYWORDS mitochondrion 8 2.684563758389262 0.10575632982374635 NM_004649, NM_001126122, NM_017446, NM_001130721, NM_178006, NM_001127242, NM_001015881, NM_001143780 121 66 1955 1.958427247683446 0.9999999988308211 0.7944516858941244 74.88897926719306 GOTERM_CC_FAT GO:0031090~organelle membrane 10 3.3557046979865772 0.11865452975536969 NM_020680, NM_001769, NM_001126122, NM_001130721, NM_001127242, NM_004176, NM_012205, NM_024591, NM_001097642, NM_001143780 72 109 1332 1.6972477064220184 0.9999999999926773 0.902792980874757 79.54553322288864 GOTERM_CC_FAT GO:0031966~mitochondrial membrane 4 1.342281879194631 0.1841323868534282 NM_001126122, NM_001127242, NM_012205, NM_001143780 72 28 1332 2.6428571428571423 1.0 0.9243733500337608 92.24567375449263 GOTERM_CC_FAT GO:0044429~mitochondrial part 5 1.6778523489932886 0.19238704831937917 NM_001126122, NM_017446, NM_001127242, NM_012205, NM_001143780 72 43 1332 2.1511627906976742 1.0 0.9101621896604265 93.17576616087375 GOTERM_CC_FAT GO:0005740~mitochondrial envelope 4 1.342281879194631 0.22638538232171707 NM_001126122, NM_001127242, NM_012205, NM_001143780 72 31 1332 2.3870967741935485 1.0 0.9355869184213116 96.02473394955085 GOTERM_CC_FAT GO:0005635~nuclear envelope 3 1.006711409395973 0.4457886401264923 NM_015446, NM_004176, NM_133337 72 28 1332 1.982142857142857 1.0 0.9790353580203544 99.93982649629325 Annotation Cluster 14 Enrichment Score: 0.7750601536868204 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS zinc-finger 19 6.375838926174497 0.037193928590698914 NM_007368, NM_017742, NM_003407, NM_183048, NM_005270, NM_030665, NM_207292, NM_001039360, NM_001018011, NM_001654, NM_006186, NM_001009992, NM_021724, NM_001206, NM_016270, NM_018660, NM_006734, NM_001135592, NM_032246 121 190 1955 1.615702479338843 0.9990642864330765 0.6307622189961151 37.4113401351772 GOTERM_MF_FAT GO:0008270~zinc ion binding 23 7.718120805369128 0.05119635884651007 NM_022748, NM_007368, NM_017742, NM_003407, NM_004104, NM_183048, NM_005270, NM_030665, NM_007038, NM_001039360, NM_207292, NM_001018011, NM_001654, NM_006769, NM_006186, NM_001009992, NM_021724, NM_001206, NM_016270, NM_018660, NM_006734, NM_001135592, NM_032246 90 251 1425 1.4508632138114208 0.9999974402122442 0.8000020727726853 49.36609963886481 SP_PIR_KEYWORDS zinc 22 7.38255033557047 0.0644846677048928 NM_022748, NM_007368, NM_017742, NM_003407, NM_183048, NM_005270, NM_030665, NM_007038, NM_207292, NM_001039360, NM_001018011, NM_001654, NM_006769, NM_006186, NM_001009992, NM_021724, NM_001206, NM_016270, NM_018660, NM_006734, NM_001135592, NM_032246 121 245 1955 1.4508348794063082 0.9999952862410713 0.7066833361033827 56.13566276909994 GOTERM_MF_FAT GO:0046914~transition metal ion binding 25 8.389261744966444 0.12943232417705713 NM_022748, NM_007368, NM_003407, NM_004104, NM_183048, NM_005270, NM_012205, NM_007038, NM_001039360, NM_001018011, NM_001009992, NM_018660, NM_004776, NM_006734, NM_017742, NM_030665, NM_207292, NM_006769, NM_001654, NM_006186, NM_021724, NM_001206, NM_016270, NM_032246, NM_001135592 90 308 1425 1.2851731601731602 0.9999999999999982 0.9664909453883677 83.38641754347398 SP_PIR_KEYWORDS metal-binding 26 8.724832214765101 0.18210847344201603 NM_022748, NM_007368, NM_003407, NM_183048, NM_005270, NM_012205, NM_007038, NM_001039360, NM_001018011, NM_001009992, NM_018660, NM_004776, NM_006734, NM_133494, NM_017742, NM_030665, NM_207292, NM_001654, NM_006769, NM_006186, NM_021724, NM_001206, NM_016270, NM_032246, NM_001135592, NM_006045 121 340 1955 1.2355371900826446 0.9999999999999999 0.9009166567369107 91.66923809294713 GOTERM_MF_FAT GO:0046872~metal ion binding 31 10.40268456375839 0.5796572386482328 NM_022748, NM_007368, NM_003407, NM_004104, NM_183048, NM_005270, NM_012205, NM_001039360, NM_007038, NM_001018011, NM_001009992, NM_138705, NM_004924, NM_004776, NM_018660, NM_006734, NM_133494, NM_001135101, NM_017742, NM_013302, NM_030665, NM_207292, NM_001654, NM_006769, NM_006186, NM_021724, NM_001206, NM_016270, NM_032246, NM_001135592, NM_006045 90 487 1425 1.0078713210130048 1.0 0.9999356849640857 99.99866403834136 GOTERM_MF_FAT GO:0043169~cation binding 31 10.40268456375839 0.6020270950671713 NM_022748, NM_007368, NM_003407, NM_004104, NM_183048, NM_005270, NM_012205, NM_001039360, NM_007038, NM_001018011, NM_001009992, NM_138705, NM_004924, NM_004776, NM_018660, NM_006734, NM_133494, NM_001135101, NM_017742, NM_013302, NM_030665, NM_207292, NM_001654, NM_006769, NM_006186, NM_021724, NM_001206, NM_016270, NM_032246, NM_001135592, NM_006045 90 491 1425 0.9996605566870331 1.0 0.9999453525443761 99.99934198063313 GOTERM_MF_FAT GO:0043167~ion binding 31 10.40268456375839 0.624009170225704 NM_022748, NM_007368, NM_003407, NM_004104, NM_183048, NM_005270, NM_012205, NM_001039360, NM_007038, NM_001018011, NM_001009992, NM_138705, NM_004924, NM_004776, NM_018660, NM_006734, NM_133494, NM_001135101, NM_017742, NM_013302, NM_030665, NM_207292, NM_001654, NM_006769, NM_006186, NM_021724, NM_001206, NM_016270, NM_032246, NM_001135592, NM_006045 90 495 1425 0.9915824915824915 1.0 0.9999539459541124 99.9996847249653 Annotation Cluster 15 Enrichment Score: 0.7739542751026962 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030902~hindbrain development 3 1.006711409395973 0.11090082589574023 NM_005596, NM_005270, NM_005524 97 9 1483 5.096219931271478 1.0 0.9406092516025955 84.83093060931611 GOTERM_BP_FAT GO:0035295~tube development 6 2.013422818791946 0.11149612802252487 NM_006769, NM_022748, NM_005596, NM_005270, NM_005524, NM_003370 97 40 1483 2.2932989690721652 1.0 0.9379953109309185 84.99306379847036 GOTERM_BP_FAT GO:0030324~lung development 4 1.342281879194631 0.150280063305145 NM_022748, NM_005596, NM_005270, NM_005524 97 21 1483 2.912125675012273 1.0 0.960265780201677 92.66663019767957 GOTERM_BP_FAT GO:0030323~respiratory tube development 4 1.342281879194631 0.150280063305145 NM_022748, NM_005596, NM_005270, NM_005524 97 21 1483 2.912125675012273 1.0 0.960265780201677 92.66663019767957 GOTERM_BP_FAT GO:0060541~respiratory system development 4 1.342281879194631 0.18274208687727558 NM_022748, NM_005596, NM_005270, NM_005524 97 23 1483 2.6588973554459883 1.0 0.9731205707744298 96.07451723029968 GOTERM_BP_FAT GO:0030900~forebrain development 3 1.006711409395973 0.4450803946170493 NM_005596, NM_005270, NM_005524 97 23 1483 1.9941730165844913 1.0 0.9984279600833147 99.99212163059258 Annotation Cluster 16 Enrichment Score: 0.7530945854298656 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000122~negative regulation of transcription from RNA polymerase II promoter 8 2.684563758389262 0.05507678252275978 NM_006312, NM_016734, NM_005994, NM_001123384, NM_205843, NM_001131010, NM_017745, NM_005270, NM_005524 97 54 1483 2.2649866361206565 1.0 0.8391718623605102 59.70393439380213 GOTERM_BP_FAT GO:0010553~negative regulation of specific transcription from RNA polymerase II promoter 3 1.006711409395973 0.11090082589574023 NM_006312, NM_001123384, NM_017745, NM_005524 97 9 1483 5.096219931271478 1.0 0.9406092516025955 84.83093060931611 GOTERM_BP_FAT GO:0032582~negative regulation of gene-specific transcription 3 1.006711409395973 0.15593421604520108 NM_006312, NM_001123384, NM_017745, NM_005524 97 11 1483 4.169634489222118 1.0 0.9609908272662946 93.41154005034963 GOTERM_BP_FAT GO:0010551~regulation of specific transcription from RNA polymerase II promoter 3 1.006711409395973 0.32691524289690393 NM_006312, NM_001123384, NM_017745, NM_005524 97 18 1483 2.548109965635739 1.0 0.9957064742429984 99.82559566089483 GOTERM_BP_FAT GO:0032583~regulation of gene-specific transcription 3 1.006711409395973 0.5511212272704163 NM_006312, NM_001123384, NM_017745, NM_005524 97 28 1483 1.6380706921944035 1.0 0.9995602618227468 99.9997377163782 Annotation Cluster 17 Enrichment Score: 0.7190818811505612 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0021915~neural tube development 4 1.342281879194631 0.022608940923462245 NM_006769, NM_005270, NM_005524, NM_003370 97 10 1483 6.115463917525774 0.9999999999938739 0.6745486239210042 30.71213933014958 GOTERM_BP_FAT GO:0035295~tube development 6 2.013422818791946 0.11149612802252487 NM_006769, NM_022748, NM_005596, NM_005270, NM_005524, NM_003370 97 40 1483 2.2932989690721652 1.0 0.9379953109309185 84.99306379847036 GOTERM_BP_FAT GO:0009792~embryonic development ending in birth or egg hatching 8 2.684563758389262 0.1216658877931789 NM_006769, NM_013275, NM_005194, NM_002211, NM_005270, NM_005524, NM_003370, NM_207292 97 65 1483 1.8816812053925456 1.0 0.9434045492346551 87.52389456134824 GOTERM_BP_FAT GO:0043009~chordate embryonic development 8 2.684563758389262 0.1216658877931789 NM_006769, NM_013275, NM_005194, NM_002211, NM_005270, NM_005524, NM_003370, NM_207292 97 65 1483 1.8816812053925456 1.0 0.9434045492346551 87.52389456134824 GOTERM_BP_FAT GO:0016331~morphogenesis of embryonic epithelium 3 1.006711409395973 0.1329737971390065 NM_006769, NM_005270, NM_003370 97 10 1483 4.5865979381443305 1.0 0.9493692414230721 89.8657598798919 GOTERM_BP_FAT GO:0002009~morphogenesis of an epithelium 3 1.006711409395973 0.2282068959117894 NM_006769, NM_005270, NM_003370 97 14 1483 3.276141384388807 1.0 0.9855704178131723 98.43300232775212 GOTERM_BP_FAT GO:0001701~in utero embryonic development 5 1.6778523489932886 0.2570819709626588 NM_013275, NM_005194, NM_002211, NM_005524, NM_207292 97 40 1483 1.9110824742268042 1.0 0.9905314913725419 99.15007546558627 GOTERM_BP_FAT GO:0048598~embryonic morphogenesis 6 2.013422818791946 0.30720361121262396 NM_006769, NM_005270, NM_005524, NM_003370, NM_207292, NM_001018011 97 57 1483 1.6093326098752034 1.0 0.9943695028213885 99.7228708735345 GOTERM_BP_FAT GO:0035239~tube morphogenesis 3 1.006711409395973 0.48917735098469983 NM_006769, NM_005270, NM_003370 97 25 1483 1.834639175257732 1.0 0.9989865767798621 99.99791312419521 GOTERM_BP_FAT GO:0048729~tissue morphogenesis 3 1.006711409395973 0.5104055548445112 NM_006769, NM_005270, NM_003370 97 26 1483 1.7640761300555117 1.0 0.9992527929458318 99.99894379658042 GOTERM_BP_FAT GO:0060429~epithelium development 3 1.006711409395973 0.5511212272704163 NM_006769, NM_005270, NM_003370 97 28 1483 1.6380706921944035 1.0 0.9995602618227468 99.9997377163782 Annotation Cluster 18 Enrichment Score: 0.6720673761012587 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY hsa04910:Insulin signaling pathway 7 2.348993288590604 0.003918441729125078 NM_001654, NM_005544, NM_020979, NM_138705, NM_004104, NM_004176, NM_003955 38 28 631 4.151315789473684 0.24327537594946702 0.24327537594946702 3.9930959536220723 GOTERM_BP_FAT GO:0043434~response to peptide hormone stimulus 4 1.342281879194631 0.21688361585441113 NM_005544, NM_020979, NM_003955, NM_006763 97 25 1483 2.446185567010309 1.0 0.9827334935729891 98.02051093780777 GOTERM_BP_FAT GO:0009991~response to extracellular stimulus 4 1.342281879194631 0.27024364547530405 NM_004417, NM_006186, NM_004176, NM_003955 97 28 1483 2.1840942562592045 1.0 0.9918240490268094 99.36198502759709 GOTERM_BP_FAT GO:0032868~response to insulin stimulus 3 1.006711409395973 0.32691524289690393 NM_005544, NM_020979, NM_003955 97 18 1483 2.548109965635739 1.0 0.9957064742429984 99.82559566089483 GOTERM_BP_FAT GO:0009719~response to endogenous stimulus 6 2.013422818791946 0.3602147650873688 NM_004417, NM_006186, NM_005544, NM_020979, NM_003955, NM_006763 97 61 1483 1.5038026026702722 1.0 0.996752814337497 99.9227284133979 GOTERM_BP_FAT GO:0032870~cellular response to hormone stimulus 3 1.006711409395973 0.39899591347664665 NM_004417, NM_005544, NM_020979 97 21 1483 2.184094256259205 1.0 0.9977910965570214 99.97166538677436 GOTERM_BP_FAT GO:0009725~response to hormone stimulus 5 1.6778523489932886 0.4824061285836581 NM_004417, NM_005544, NM_020979, NM_003955, NM_006763 97 55 1483 1.3898781630740393 1.0 0.9989764075802077 99.99742218513717 GOTERM_BP_FAT GO:0010033~response to organic substance 7 2.348993288590604 0.8072116427036078 NM_004417, NM_006186, NM_005544, NM_020979, NM_003955, NM_006763, NM_058246 97 120 1483 0.8918384879725084 1.0 0.9999967698251612 99.99999999966126 Annotation Cluster 19 Enrichment Score: 0.6558353405054748 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS zinc-finger 19 6.375838926174497 0.037193928590698914 NM_007368, NM_017742, NM_003407, NM_183048, NM_005270, NM_030665, NM_207292, NM_001039360, NM_001018011, NM_001654, NM_006186, NM_001009992, NM_021724, NM_001206, NM_016270, NM_018660, NM_006734, NM_001135592, NM_032246 121 190 1955 1.615702479338843 0.9990642864330765 0.6307622189961151 37.4113401351772 UP_SEQ_FEATURE zinc finger region:C2H2-type 3 7 2.348993288590604 0.1410514254003596 NM_001009992, NM_001206, NM_016270, NM_005270, NM_006734, NM_001039360, NM_001018011 121 58 1955 1.94998575092619 1.0 0.9951719554664387 88.48082231477028 UP_SEQ_FEATURE zinc finger region:C2H2-type 1 7 2.348993288590604 0.1410514254003596 NM_001009992, NM_001206, NM_016270, NM_005270, NM_006734, NM_001039360, NM_001018011 121 58 1955 1.94998575092619 1.0 0.9951719554664387 88.48082231477028 INTERPRO IPR013087:Zinc finger, C2H2-type/integrase, DNA-binding 7 2.348993288590604 0.14621589593662399 NM_001009992, NM_001206, NM_016270, NM_005270, NM_006734, NM_001039360, NM_001018011 119 54 1769 1.9270152505446623 1.0 0.9999998315998829 87.85267300432838 SP_PIR_KEYWORDS zinc finger 4 1.342281879194631 0.21129248747725307 NM_005270, NM_006734, NM_001135592, NM_001018011 121 26 1955 2.485696122059758 1.0 0.8996048750295417 94.6837559956222 INTERPRO IPR015880:Zinc finger, C2H2-like 8 2.684563758389262 0.2501524888386078 NM_001009992, NM_001206, NM_016270, NM_005270, NM_006734, NM_018660, NM_001039360, NM_001018011 119 77 1769 1.544472334388301 1.0 0.9999993207978055 97.84879855899474 INTERPRO IPR007087:Zinc finger, C2H2-type 8 2.684563758389262 0.27130489551801423 NM_001009992, NM_001206, NM_016270, NM_005270, NM_006734, NM_018660, NM_001039360, NM_001018011 119 79 1769 1.5053717689607489 1.0 0.9999984595302864 98.53121782815529 UP_SEQ_FEATURE zinc finger region:C2H2-type 2 6 2.013422818791946 0.3186483204356324 NM_001009992, NM_001206, NM_016270, NM_006734, NM_001039360, NM_001018011 121 61 1955 1.5892155534480423 1.0 0.999759132908182 99.5718746665243 SMART SM00355:ZnF_C2H2 8 2.684563758389262 0.3258264122547201 NM_001009992, NM_001206, NM_016270, NM_005270, NM_006734, NM_018660, NM_001039360, NM_001018011 82 77 1112 1.4089325308837504 0.9999999999999972 0.9997701738992548 98.56185905682695 UP_SEQ_FEATURE zinc finger region:C2H2-type 4 4 1.342281879194631 0.5293316664946626 NM_001009992, NM_005270, NM_006734, NM_001018011 121 45 1955 1.436179981634527 1.0 0.9999928595562364 99.99777140432747 UP_SEQ_FEATURE zinc finger region:C2H2-type 5 3 1.006711409395973 0.7161720088346746 NM_001009992, NM_005270, NM_001018011 121 40 1955 1.2117768595041323 1.0 0.9999999909921993 99.99999831799165 Annotation Cluster 20 Enrichment Score: 0.6314325641270132 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051276~chromosome organization 7 2.348993288590604 0.07178757189237975 NM_020732, NM_001042572, NM_001123384, NM_175709, NM_139135, NM_001131010, NM_017745, NM_001983 97 46 1483 2.3265351860152395 1.0 0.8714360253451237 69.7353467670801 GOTERM_CC_FAT GO:0044427~chromosomal part 4 1.342281879194631 0.30018055153981815 NM_015446, NM_001042572, NM_175709, NM_001983 72 36 1332 2.0555555555555554 1.0 0.9628769529244245 98.8719614627058 GOTERM_CC_FAT GO:0000785~chromatin 3 1.006711409395973 0.3295024172564954 NM_015446, NM_001042572, NM_175709 72 22 1332 2.522727272727273 1.0 0.9706392776052177 99.34118308728569 GOTERM_CC_FAT GO:0005694~chromosome 4 1.342281879194631 0.41973899959627586 NM_015446, NM_001042572, NM_175709, NM_001983 72 44 1332 1.6818181818181819 1.0 0.9778505127503473 99.89283775945546 Annotation Cluster 21 Enrichment Score: 0.5777143154243779 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007292~female gamete generation 4 1.342281879194631 0.04678139667056395 NM_201559, NM_001039591, NM_001983, NM_001956, NM_001455 97 13 1483 4.704203013481364 1.0 0.8155469974863796 53.63765807388396 GOTERM_BP_FAT GO:0019953~sexual reproduction 8 2.684563758389262 0.05053272310245365 NM_016734, NM_001769, NM_201559, NM_002211, NM_001039591, NM_001983, NM_001956, NM_001455, NM_001018011 97 53 1483 2.307722233028594 1.0 0.8303542118588667 56.47989376124467 GOTERM_BP_FAT GO:0007276~gamete generation 7 2.348993288590604 0.09908824112045142 NM_016734, NM_201559, NM_002211, NM_001039591, NM_001983, NM_001956, NM_001455, NM_001018011 97 50 1483 2.1404123711340204 1.0 0.9312634274474062 81.25334781074038 GOTERM_BP_FAT GO:0048610~reproductive cellular process 4 1.342281879194631 0.18274208687727558 NM_201559, NM_002211, NM_001983, NM_001455, NM_001018011 97 23 1483 2.6588973554459883 1.0 0.9731205707744298 96.07451723029968 GOTERM_BP_FAT GO:0048609~reproductive process in a multicellular organism 7 2.348993288590604 0.2627490119100463 NM_016734, NM_201559, NM_002211, NM_001039591, NM_001983, NM_001956, NM_001455, NM_001018011 97 67 1483 1.5973226650253884 1.0 0.9910345549866568 99.24833278642417 GOTERM_BP_FAT GO:0032504~multicellular organism reproduction 7 2.348993288590604 0.2627490119100463 NM_016734, NM_201559, NM_002211, NM_001039591, NM_001983, NM_001956, NM_001455, NM_001018011 97 67 1483 1.5973226650253884 1.0 0.9910345549866568 99.24833278642417 GOTERM_BP_FAT GO:0008406~gonad development 3 1.006711409395973 0.30234583745919485 NM_201559, NM_001983, NM_001956, NM_001455 97 17 1483 2.697998787143723 1.0 0.9945450348824216 99.68999494288883 GOTERM_BP_FAT GO:0048608~reproductive structure development 3 1.006711409395973 0.32691524289690393 NM_201559, NM_001983, NM_001956, NM_001455 97 18 1483 2.548109965635739 1.0 0.9957064742429984 99.82559566089483 GOTERM_BP_FAT GO:0007281~germ cell development 3 1.006711409395973 0.35126070715651897 NM_201559, NM_001983, NM_001455, NM_001018011 97 19 1483 2.4139989148128054 1.0 0.9965890519277263 99.90342581825618 GOTERM_BP_FAT GO:0045137~development of primary sexual characteristics 3 1.006711409395973 0.35126070715651897 NM_201559, NM_001983, NM_001956, NM_001455 97 19 1483 2.4139989148128054 1.0 0.9965890519277263 99.90342581825618 GOTERM_BP_FAT GO:0007548~sex differentiation 3 1.006711409395973 0.39899591347664665 NM_201559, NM_001983, NM_001956, NM_001455 97 21 1483 2.184094256259205 1.0 0.9977910965570214 99.97166538677436 GOTERM_BP_FAT GO:0003006~reproductive developmental process 4 1.342281879194631 0.5355290195835959 NM_201559, NM_001983, NM_001956, NM_001455, NM_001018011 97 43 1483 1.4222009110525053 1.0 0.9994624707418349 99.99954637664203 SP_PIR_KEYWORDS Proto-oncogene 4 1.342281879194631 0.6161870758298186 NM_001654, NM_016734, NM_201559, NM_001455, NM_001018011 121 51 1955 1.2672176308539946 1.0 0.9959384886665827 99.99927789163716 GOTERM_BP_FAT GO:0048232~male gamete generation 3 1.006711409395973 0.6745545490585081 NM_016734, NM_001983, NM_001018011 97 35 1483 1.3104565537555228 1.0 0.9999323587978933 99.99999849263752 GOTERM_BP_FAT GO:0007283~spermatogenesis 3 1.006711409395973 0.6745545490585081 NM_016734, NM_001983, NM_001018011 97 35 1483 1.3104565537555228 1.0 0.9999323587978933 99.99999849263752 Annotation Cluster 22 Enrichment Score: 0.5552754647574096 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045165~cell fate commitment 4 1.342281879194631 0.16627136967724773 NM_005994, NM_002211, NM_005270, NM_005524 97 22 1483 2.7797563261480787 1.0 0.9654609889947269 94.59341107896628 GOTERM_BP_FAT GO:0048732~gland development 4 1.342281879194631 0.19963236148527208 NM_005994, NM_005544, NM_005270, NM_005524 97 24 1483 2.5481099656357387 1.0 0.9790967718120261 97.19210727146871 GOTERM_BP_FAT GO:0030879~mammary gland development 3 1.006711409395973 0.20372263865869755 NM_005994, NM_005544, NM_005270 97 13 1483 3.5281522601110233 1.0 0.9796950888304665 97.41369191684008 GOTERM_BP_FAT GO:0008284~positive regulation of cell proliferation 7 2.348993288590604 0.4766361209798522 NM_022748, NM_005994, NM_005544, NM_002211, NM_005270, NM_005524, NM_001956 97 85 1483 1.2590661006670707 1.0 0.9989210897567958 99.99692037867062 GOTERM_BP_FAT GO:0007507~heart development 4 1.342281879194631 0.5192159361257305 NM_005994, NM_001123384, NM_002211, NM_017745, NM_005270 97 42 1483 1.4560628375061364 1.0 0.9992917449668558 99.99921074350414 Annotation Cluster 23 Enrichment Score: 0.5379514001423101 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005813~centrosome 4 1.342281879194631 0.1318962402010262 NM_020680, NM_004649, NM_133337, NM_025241 72 24 1332 3.083333333333333 0.9999999999996612 0.8901569740793016 83.088495598196 GOTERM_CC_FAT GO:0005815~microtubule organizing center 4 1.342281879194631 0.1573193859234933 NM_020680, NM_004649, NM_133337, NM_025241 72 26 1332 2.846153846153846 0.9999999999999992 0.9164178488420379 88.35896807856983 GOTERM_CC_FAT GO:0044430~cytoskeletal part 8 2.684563758389262 0.27137505320363975 NM_020680, NM_004649, NM_173352, NM_020979, NM_133337, NM_025241, NM_004924, NM_004523 72 99 1332 1.4949494949494948 1.0 0.9531324389309105 98.12746681443846 GOTERM_CC_FAT GO:0015630~microtubule cytoskeleton 5 1.6778523489932886 0.4729048268273408 NM_020680, NM_004649, NM_133337, NM_025241, NM_004523 72 66 1332 1.4015151515151516 1.0 0.9781468538892981 99.96796166870269 GOTERM_CC_FAT GO:0005856~cytoskeleton 9 3.0201342281879198 0.7671577425742283 NM_020680, NM_004649, NM_173352, NM_020979, NM_133337, NM_025241, NM_004924, NM_003370, NM_004523 72 180 1332 0.9249999999999999 1.0 0.9981539406818446 99.99999888458431 Annotation Cluster 24 Enrichment Score: 0.5209782084429371 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0003002~regionalization 4 1.342281879194631 0.2522432046874068 NM_005270, NM_006763, NM_005524, NM_001018011 97 27 1483 2.2649866361206565 1.0 0.990168674945164 99.05677381054203 GOTERM_BP_FAT GO:0007389~pattern specification process 5 1.6778523489932886 0.2718175236818549 NM_001123384, NM_017745, NM_005270, NM_006763, NM_005524, NM_001018011 97 41 1483 1.8644707065627355 1.0 0.9915616766423672 99.38370725456737 GOTERM_BP_FAT GO:0009952~anterior/posterior pattern formation 3 1.006711409395973 0.39899591347664665 NM_006763, NM_005524, NM_001018011 97 21 1483 2.184094256259205 1.0 0.9977910965570214 99.97166538677436 Annotation Cluster 25 Enrichment Score: 0.5025575750407613 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006936~muscle contraction 4 1.342281879194631 0.150280063305145 NM_145109, NM_133337, NM_006056, NM_001956 97 21 1483 2.912125675012273 1.0 0.960265780201677 92.66663019767957 GOTERM_BP_FAT GO:0003012~muscle system process 4 1.342281879194631 0.19963236148527208 NM_145109, NM_133337, NM_006056, NM_001956 97 24 1483 2.5481099656357387 1.0 0.9790967718120261 97.19210727146871 GOTERM_BP_FAT GO:0003013~circulatory system process 3 1.006711409395973 0.5705828227308664 NM_145109, NM_133337, NM_001956 97 29 1483 1.581585495911838 1.0 0.9996484337777961 99.99987119569292 GOTERM_BP_FAT GO:0008015~blood circulation 3 1.006711409395973 0.5705828227308664 NM_145109, NM_133337, NM_001956 97 29 1483 1.581585495911838 1.0 0.9996484337777961 99.99987119569292 Annotation Cluster 26 Enrichment Score: 0.48923720577254637 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001655~urogenital system development 3 1.006711409395973 0.2282068959117894 NM_032199, NM_005270, NM_001018011 97 14 1483 3.276141384388807 1.0 0.9855704178131723 98.43300232775212 GOTERM_BP_FAT GO:0001822~kidney development 3 1.006711409395973 0.2282068959117894 NM_032199, NM_005270, NM_001018011 97 14 1483 3.276141384388807 1.0 0.9855704178131723 98.43300232775212 GOTERM_BP_FAT GO:0001501~skeletal system development 4 1.342281879194631 0.6540799781403913 NM_013275, NM_032199, NM_005270, NM_001018011 97 51 1483 1.199110572063877 1.0 0.9999008754407928 99.99999598816964 Annotation Cluster 27 Enrichment Score: 0.4860132384073469 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0014706~striated muscle tissue development 3 1.006711409395973 0.30234583745919485 NM_005994, NM_002211, NM_207292 97 17 1483 2.697998787143723 1.0 0.9945450348824216 99.68999494288883 GOTERM_BP_FAT GO:0007517~muscle organ development 4 1.342281879194631 0.3066332611961843 NM_005994, NM_002211, NM_032199, NM_207292 97 30 1483 2.038487972508591 1.0 0.994664438225896 99.71918770898547 GOTERM_BP_FAT GO:0060537~muscle tissue development 3 1.006711409395973 0.32691524289690393 NM_005994, NM_002211, NM_207292 97 18 1483 2.548109965635739 1.0 0.9957064742429984 99.82559566089483 GOTERM_BP_FAT GO:0042692~muscle cell differentiation 3 1.006711409395973 0.37530868965098807 NM_005994, NM_002211, NM_207292 97 20 1483 2.2932989690721652 1.0 0.9974417907500697 99.94731778804923 Annotation Cluster 28 Enrichment Score: 0.47071293323188 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:ANK 3 4 1.342281879194631 0.22779393800705067 NM_013275, NM_017664, NM_032250, NM_001123384, NM_017745 121 27 1955 2.393633302724212 1.0 0.9985681157871347 97.4633498676127 UP_SEQ_FEATURE repeat:ANK 1 4 1.342281879194631 0.2957402676133116 NM_013275, NM_017664, NM_032250, NM_001123384, NM_017745 121 31 1955 2.0847773926952815 1.0 0.9997783903966421 99.31498038389752 UP_SEQ_FEATURE repeat:ANK 2 4 1.342281879194631 0.3129987679696461 NM_013275, NM_017664, NM_032250, NM_001123384, NM_017745 121 32 1955 2.019628099173554 1.0 0.9998082959171114 99.51855764097736 SP_PIR_KEYWORDS ank repeat 4 1.342281879194631 0.33028778257590063 NM_013275, NM_017664, NM_032250, NM_001123384, NM_017745 121 33 1955 1.958427247683446 1.0 0.9701840136386515 99.29609949722169 INTERPRO IPR002110:Ankyrin 4 1.342281879194631 0.37976405655358453 NM_013275, NM_017664, NM_032250, NM_001123384, NM_017745 119 33 1769 1.8018843901196842 1.0 0.999999978884254 99.82875870040363 SMART SM00248:ANK 4 1.342281879194631 0.4365793834646241 NM_013275, NM_017664, NM_032250, NM_001123384, NM_017745 82 33 1112 1.6437546193643755 1.0 0.999704790447934 99.79141798515384 UP_SEQ_FEATURE repeat:ANK 4 3 1.006711409395973 0.4390809800340996 NM_013275, NM_017664, NM_032250 121 24 1955 2.019628099173554 1.0 0.9999830525966913 99.97302798279428 Annotation Cluster 29 Enrichment Score: 0.46559574314707003 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006928~cell motion 11 3.691275167785235 0.06764205417486606 NM_022748, NM_006186, NM_020796, NM_001769, NM_002211, NM_032199, NM_005270, NM_001627, NM_003370, NM_001956, NM_001135592 97 92 1483 1.827991931869117 1.0 0.8683389006233271 67.49235235262486 GOTERM_BP_FAT GO:0016477~cell migration 5 1.6778523489932886 0.5530285670245331 NM_022748, NM_006186, NM_002211, NM_032199, NM_001956 97 60 1483 1.2740549828178693 1.0 0.9995190875429645 99.99975503668459 GOTERM_BP_FAT GO:0051674~localization of cell 5 1.6778523489932886 0.6057959100619734 NM_022748, NM_006186, NM_002211, NM_032199, NM_001956 97 64 1483 1.1944265463917525 1.0 0.9997768724438952 99.9999673589475 GOTERM_BP_FAT GO:0048870~cell motility 5 1.6778523489932886 0.6057959100619734 NM_022748, NM_006186, NM_002211, NM_032199, NM_001956 97 64 1483 1.1944265463917525 1.0 0.9997768724438952 99.9999673589475 Annotation Cluster 30 Enrichment Score: 0.42968821253835887 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051301~cell division 4 1.342281879194631 0.3066332611961843 NM_015446, NM_001039591, NM_001018011, NM_004523 97 30 1483 2.038487972508591 1.0 0.994664438225896 99.71918770898547 SP_PIR_KEYWORDS cell division 3 1.006711409395973 0.37293148626160244 NM_015446, NM_001039591, NM_004523 121 21 1955 2.3081463990554902 1.0 0.9760932821050771 99.68791742174942 SP_PIR_KEYWORDS cell cycle 4 1.342281879194631 0.44945586134349624 NM_004417, NM_015446, NM_001039591, NM_004523 121 40 1955 1.6157024793388428 1.0 0.985357813399683 99.93755532189633 Annotation Cluster 31 Enrichment Score: 0.426844521816604 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0012505~endomembrane system 8 2.684563758389262 0.19014778951711667 NM_020680, NM_015446, NM_001769, NM_001130721, NM_004176, NM_133337, NM_024591, NM_001097642 72 89 1332 1.6629213483146066 1.0 0.9194144528577507 92.93417799859736 GOTERM_CC_FAT GO:0005789~endoplasmic reticulum membrane 3 1.006711409395973 0.34947512096760525 NM_001130721, NM_004176, NM_001097642 72 23 1332 2.4130434782608696 1.0 0.9736655707296835 99.54944160673766 GOTERM_CC_FAT GO:0042175~nuclear envelope-endoplasmic reticulum network 3 1.006711409395973 0.3692550192195466 NM_001130721, NM_004176, NM_001097642 72 24 1332 2.3125 1.0 0.9726271461074755 99.69432525956998 GOTERM_CC_FAT GO:0044432~endoplasmic reticulum part 3 1.006711409395973 0.48215018475768023 NM_001130721, NM_004176, NM_001097642 72 30 1332 1.85 1.0 0.9780020511092526 99.97434872921855 GOTERM_CC_FAT GO:0005783~endoplasmic reticulum 6 2.013422818791946 0.620527597423287 NM_001135101, NM_001130721, NM_004176, NM_003827, NM_001097642, NM_021814 72 99 1332 1.121212121212121 1.0 0.9926828914199171 99.99948405655164 Annotation Cluster 32 Enrichment Score: 0.4142557961218794 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS isopeptide bond 6 2.013422818791946 0.23399362373636684 NM_002198, NM_005194, NM_001131010, NM_004924, NM_006734, NM_001135592 121 54 1955 1.795224977043159 1.0 0.9139129274641135 96.29488520354971 UP_SEQ_FEATURE cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) 3 1.006711409395973 0.3953608485149937 NM_002198, NM_005194, NM_001131010 121 22 1955 2.203230653643877 1.0 0.999970418956165 99.92161583405462 SP_PIR_KEYWORDS ubl conjugation 7 2.348993288590604 0.41256916799828847 NM_003670, NM_002198, NM_005194, NM_001131010, NM_004924, NM_006734, NM_001135592 121 84 1955 1.3464187327823691 1.0 0.9800693443321707 99.86078520938838 UP_SEQ_FEATURE cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) 3 1.006711409395973 0.5771415785134515 NM_004924, NM_006734, NM_001135592 121 31 1955 1.5635830445214611 1.0 0.9999979195189677 99.99951381151293 Annotation Cluster 33 Enrichment Score: 0.3859809427767831 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042981~regulation of apoptosis 14 4.697986577181208 0.19413766884646821 NM_004417, NM_001077654, NM_201559, NM_058246, NM_006763, NM_001455, NM_001018011, NM_006186, NM_020310, NM_001127242, NM_005194, NM_004924, NM_003955, NM_001983, NM_001135592 97 155 1483 1.380911207183239 1.0 0.9777984697612954 96.86633539846696 GOTERM_BP_FAT GO:0010941~regulation of cell death 14 4.697986577181208 0.21382661122751592 NM_004417, NM_001077654, NM_201559, NM_058246, NM_006763, NM_001455, NM_001018011, NM_006186, NM_020310, NM_001127242, NM_005194, NM_004924, NM_003955, NM_001983, NM_001135592 97 158 1483 1.3546913741354558 1.0 0.982645742171477 97.8928281314141 GOTERM_BP_FAT GO:0043067~regulation of programmed cell death 14 4.697986577181208 0.21382661122751592 NM_004417, NM_001077654, NM_201559, NM_058246, NM_006763, NM_001455, NM_001018011, NM_006186, NM_020310, NM_001127242, NM_005194, NM_004924, NM_003955, NM_001983, NM_001135592 97 158 1483 1.3546913741354558 1.0 0.982645742171477 97.8928281314141 GOTERM_BP_FAT GO:0043066~negative regulation of apoptosis 7 2.348993288590604 0.29729913341683656 NM_001077654, NM_006186, NM_005194, NM_003955, NM_001983, NM_006763, NM_001135592 97 70 1483 1.5288659793814432 1.0 0.9943337312183252 99.65199042795024 GOTERM_BP_FAT GO:0043069~negative regulation of programmed cell death 7 2.348993288590604 0.3208379954313427 NM_001077654, NM_006186, NM_005194, NM_003955, NM_001983, NM_006763, NM_001135592 97 72 1483 1.4863974799541808 1.0 0.9954501261620384 99.7985408848094 GOTERM_BP_FAT GO:0060548~negative regulation of cell death 7 2.348993288590604 0.3208379954313427 NM_001077654, NM_006186, NM_005194, NM_003955, NM_001983, NM_006763, NM_001135592 97 72 1483 1.4863974799541808 1.0 0.9954501261620384 99.7985408848094 GOTERM_BP_FAT GO:0006916~anti-apoptosis 4 1.342281879194631 0.45118438637628316 NM_001077654, NM_005194, NM_003955, NM_001135592 97 38 1483 1.6093326098752034 1.0 0.998516547089967 99.99340268247124 GOTERM_BP_FAT GO:0043065~positive regulation of apoptosis 6 2.013422818791946 0.6781940088675276 NM_004417, NM_201559, NM_001127242, NM_005194, NM_001135592, NM_001455, NM_001018011 97 87 1483 1.054390330607892 1.0 0.9999339149057288 99.99999874148703 GOTERM_BP_FAT GO:0010942~positive regulation of cell death 6 2.013422818791946 0.6882228640881213 NM_004417, NM_201559, NM_001127242, NM_005194, NM_001135592, NM_001455, NM_001018011 97 88 1483 1.0424086223055296 1.0 0.9999456187666512 99.9999992427219 GOTERM_BP_FAT GO:0043068~positive regulation of programmed cell death 6 2.013422818791946 0.6882228640881213 NM_004417, NM_201559, NM_001127242, NM_005194, NM_001135592, NM_001455, NM_001018011 97 88 1483 1.0424086223055296 1.0 0.9999456187666512 99.9999992427219 GOTERM_BP_FAT GO:0012502~induction of programmed cell death 4 1.342281879194631 0.7700731246399031 NM_201559, NM_001127242, NM_005194, NM_001135592, NM_001455 97 61 1483 1.0025350684468481 1.0 0.9999901216091575 99.99999999428036 GOTERM_BP_FAT GO:0006917~induction of apoptosis 4 1.342281879194631 0.7700731246399031 NM_201559, NM_001127242, NM_005194, NM_001135592, NM_001455 97 61 1483 1.0025350684468481 1.0 0.9999901216091575 99.99999999428036 Annotation Cluster 34 Enrichment Score: 0.3017677257626611 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS GTPase activation 4 1.342281879194631 0.33028778257590063 NM_007368, NM_000390, NM_178006, NM_032552 121 33 1955 1.958427247683446 1.0 0.9701840136386515 99.29609949722169 GOTERM_MF_FAT GO:0008047~enzyme activator activity 5 1.6778523489932886 0.4539756966563182 NM_007368, NM_000390, NM_178006, NM_032552, NM_058246 90 55 1425 1.4393939393939392 1.0 0.9997350505809293 99.96046477366069 GOTERM_MF_FAT GO:0060589~nucleoside-triphosphatase regulator activity 6 2.013422818791946 0.5340582701915638 NM_007368, NM_000390, NM_014869, NM_178006, NM_032552, NM_058246 90 77 1425 1.2337662337662336 1.0 0.9999134908203086 99.99493001275732 GOTERM_MF_FAT GO:0005096~GTPase activator activity 4 1.342281879194631 0.542226014959575 NM_007368, NM_000390, NM_178006, NM_032552 90 45 1425 1.4074074074074074 1.0 0.999890117230213 99.99596775411514 GOTERM_MF_FAT GO:0030695~GTPase regulator activity 5 1.6778523489932886 0.7136204105683128 NM_007368, NM_000390, NM_014869, NM_178006, NM_032552 90 76 1425 1.0416666666666665 1.0 0.9999923665075972 99.99999071923055 Annotation Cluster 35 Enrichment Score: 0.30055667236398687 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0042995~cell projection 8 2.684563758389262 0.35138040468931653 NM_020796, NM_020979, NM_001025101, NM_002211, NM_004924, NM_005270, NM_001627, NM_003370 72 108 1332 1.3703703703703702 1.0 0.9702587425010889 99.56574400022957 GOTERM_CC_FAT GO:0030424~axon 3 1.006711409395973 0.4641450064519168 NM_020796, NM_001025101, NM_001627 72 29 1332 1.9137931034482758 1.0 0.9784607661674063 99.96058969834768 GOTERM_CC_FAT GO:0043005~neuron projection 3 1.006711409395973 0.7689511695319342 NM_020796, NM_001025101, NM_001627 72 51 1332 1.088235294117647 1.0 0.9979629709939933 99.99999898785028 Annotation Cluster 36 Enrichment Score: 0.296969468578666 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0031410~cytoplasmic vesicle 7 2.348993288590604 0.3855317448178879 NM_020680, NM_001769, NM_004104, NM_004176, NM_133337, NM_002211, NM_004924 72 94 1332 1.377659574468085 1.0 0.9743061486666458 99.77991137694518 GOTERM_CC_FAT GO:0031982~vesicle 7 2.348993288590604 0.41543730591148864 NM_020680, NM_001769, NM_004104, NM_004176, NM_133337, NM_002211, NM_004924 72 97 1332 1.3350515463917527 1.0 0.9796049184978587 99.88241683171874 GOTERM_CC_FAT GO:0044433~cytoplasmic vesicle part 3 1.006711409395973 0.499789136649733 NM_020680, NM_001769, NM_004924 72 31 1332 1.7903225806451613 1.0 0.9798832477572237 99.98340397738697 GOTERM_CC_FAT GO:0016023~cytoplasmic membrane-bounded vesicle 5 1.6778523489932886 0.6297010545615319 NM_020680, NM_001769, NM_004104, NM_002211, NM_004924 72 80 1332 1.15625 1.0 0.9926918307451915 99.99962062395629 GOTERM_CC_FAT GO:0031988~membrane-bounded vesicle 5 1.6778523489932886 0.6496295734696177 NM_020680, NM_001769, NM_004104, NM_002211, NM_004924 72 82 1332 1.128048780487805 1.0 0.9929246841804318 99.99981067544529 Annotation Cluster 37 Enrichment Score: 0.2911996013615104 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007010~cytoskeleton organization 8 2.684563758389262 0.15317818896574287 NM_020796, NM_020979, NM_002211, NM_004924, NM_022489, NM_058246, NM_003370, NM_004523 97 69 1483 1.7725982369639923 1.0 0.9606961929817567 93.05778613259035 GOTERM_CC_FAT GO:0042995~cell projection 8 2.684563758389262 0.35138040468931653 NM_020796, NM_020979, NM_001025101, NM_002211, NM_004924, NM_005270, NM_001627, NM_003370 72 108 1332 1.3703703703703702 1.0 0.9702587425010889 99.56574400022957 GOTERM_BP_FAT GO:0030036~actin cytoskeleton organization 5 1.6778523489932886 0.42310038760456997 NM_020979, NM_002211, NM_004924, NM_022489, NM_003370 97 51 1483 1.4988882150798462 1.0 0.9983426894012594 99.98530732468777 GOTERM_BP_FAT GO:0030029~actin filament-based process 5 1.6778523489932886 0.42310038760456997 NM_020979, NM_002211, NM_004924, NM_022489, NM_003370 97 51 1483 1.4988882150798462 1.0 0.9983426894012594 99.98530732468777 GOTERM_CC_FAT GO:0015629~actin cytoskeleton 3 1.006711409395973 0.5170493685401047 NM_020979, NM_004924, NM_003370 72 32 1332 1.734375 1.0 0.9815610305416161 99.98932444815753 KEGG_PATHWAY hsa04670:Leukocyte transendothelial migration 3 1.006711409395973 0.5183272496740916 NM_002211, NM_004924, NM_003370 38 29 631 1.7177858439201452 1.0 0.9999687334831383 99.94904010213638 GOTERM_CC_FAT GO:0031252~cell leading edge 3 1.006711409395973 0.5821303080600124 NM_020979, NM_002211, NM_003370 72 36 1332 1.5416666666666665 1.0 0.9905472003591552 99.99826794647218 SP_PIR_KEYWORDS actin-binding 3 1.006711409395973 0.6118132486777217 NM_004924, NM_022489, NM_003370 121 33 1955 1.4688204357625845 1.0 0.9963628789402666 99.99916930699992 KEGG_PATHWAY hsa04510:Focal adhesion 3 1.006711409395973 0.8292013093208216 NM_002211, NM_004924, NM_003370 38 52 631 0.957995951417004 1.0 0.9999998457233262 99.99999891900593 GOTERM_MF_FAT GO:0003779~actin binding 3 1.006711409395973 0.8566145629110427 NM_004924, NM_022489, NM_003370 90 53 1425 0.8962264150943395 1.0 0.9999987539504525 99.99999999880595 GOTERM_MF_FAT GO:0008092~cytoskeletal protein binding 3 1.006711409395973 0.9587877910303403 NM_004924, NM_022489, NM_003370 90 76 1425 0.625 1.0 0.9999999871510257 100.0 Annotation Cluster 38 Enrichment Score: 0.2883224627767929 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR003659:Plexin/semaphorin/integrin 3 1.006711409395973 0.23871693900835952 NM_020796, NM_002211, NM_012401 119 14 1769 3.1854741896758707 1.0 0.9999999028298078 97.36767660764518 SMART SM00423:PSI 3 1.006711409395973 0.27149444803845013 NM_020796, NM_002211, NM_012401 82 14 1112 2.905923344947735 0.9999999999979733 0.9998734493053093 96.6890512877006 KEGG_PATHWAY hsa04360:Axon guidance 4 1.342281879194631 0.2874089829191499 NM_020796, NM_080872, NM_002211, NM_012401 38 32 631 2.075657894736842 0.9999999999643824 0.9975570414730854 97.03104040008962 SP_PIR_KEYWORDS Secreted 3 1.006711409395973 0.999843122098041 NM_001135101, NM_007038, NM_001956 121 171 1955 0.28345657532260404 1.0 0.9999999999829975 100.0 UP_SEQ_FEATURE signal peptide 8 2.684563758389262 0.9999871426996773 NM_020796, NM_001135101, NM_080872, NM_002211, NM_001627, NM_007038, NM_001956, NM_012401 121 355 1955 0.3641019671749506 1.0 1.0 100.0 SP_PIR_KEYWORDS signal 8 2.684563758389262 0.9999871426996773 NM_020796, NM_001135101, NM_080872, NM_002211, NM_001627, NM_007038, NM_001956, NM_012401 121 355 1955 0.3641019671749506 1.0 0.9999999999999768 100.0 Annotation Cluster 39 Enrichment Score: 0.2835752345802562 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Apoptosis 6 2.013422818791946 0.4065111545604262 NM_019058, NM_001077654, NM_080872, NM_201559, NM_001127242, NM_001015881, NM_001455 121 68 1955 1.4256198347107438 1.0 0.9816840422452081 99.84195843801437 GOTERM_BP_FAT GO:0016265~death 10 3.3557046979865772 0.41097105835274295 NM_019058, NM_001077654, NM_006186, NM_020796, NM_080872, NM_201559, NM_001127242, NM_001015881, NM_001135592, NM_001455, NM_001018011 97 124 1483 1.2329564349850348 1.0 0.998145378167207 99.97948458284786 GOTERM_BP_FAT GO:0006915~apoptosis 9 3.0201342281879198 0.42009480024560975 NM_019058, NM_001077654, NM_020796, NM_080872, NM_201559, NM_001127242, NM_001015881, NM_001135592, NM_001455, NM_001018011 97 110 1483 1.2508903467666355 1.0 0.9983519144456053 99.98402987961859 GOTERM_BP_FAT GO:0012501~programmed cell death 9 3.0201342281879198 0.44078978923283096 NM_019058, NM_001077654, NM_020796, NM_080872, NM_201559, NM_001127242, NM_001015881, NM_001135592, NM_001455, NM_001018011 97 112 1483 1.2285530191458027 1.0 0.9984922150549628 99.99108536050015 GOTERM_BP_FAT GO:0008219~cell death 9 3.0201342281879198 0.5421549703568491 NM_019058, NM_001077654, NM_020796, NM_080872, NM_201559, NM_001127242, NM_001015881, NM_001135592, NM_001455, NM_001018011 97 122 1483 1.1278519520027042 1.0 0.9995012819422733 99.9996397700897 GOTERM_BP_FAT GO:0043065~positive regulation of apoptosis 6 2.013422818791946 0.6781940088675276 NM_004417, NM_201559, NM_001127242, NM_005194, NM_001135592, NM_001455, NM_001018011 97 87 1483 1.054390330607892 1.0 0.9999339149057288 99.99999874148703 GOTERM_BP_FAT GO:0010942~positive regulation of cell death 6 2.013422818791946 0.6882228640881213 NM_004417, NM_201559, NM_001127242, NM_005194, NM_001135592, NM_001455, NM_001018011 97 88 1483 1.0424086223055296 1.0 0.9999456187666512 99.9999992427219 GOTERM_BP_FAT GO:0043068~positive regulation of programmed cell death 6 2.013422818791946 0.6882228640881213 NM_004417, NM_201559, NM_001127242, NM_005194, NM_001135592, NM_001455, NM_001018011 97 88 1483 1.0424086223055296 1.0 0.9999456187666512 99.9999992427219 Annotation Cluster 40 Enrichment Score: 0.2748513045720199 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030097~hemopoiesis 5 1.6778523489932886 0.43810115710146097 NM_002198, NM_002221, NM_002211, NM_001983, NM_001018011 97 52 1483 1.4700634417129264 1.0 0.9985084412114881 99.99037226592932 GOTERM_BP_FAT GO:0001775~cell activation 6 2.013422818791946 0.4663872870249035 NM_001769, NM_002198, NM_002221, NM_002211, NM_001983, NM_001956 97 69 1483 1.3294486777229944 1.0 0.9988331048292366 99.9957963518325 GOTERM_BP_FAT GO:0048534~hemopoietic or lymphoid organ development 5 1.6778523489932886 0.46777053139591573 NM_002198, NM_002221, NM_002211, NM_001983, NM_001018011 97 54 1483 1.4156166475754104 1.0 0.998790251565473 99.99596781186044 GOTERM_BP_FAT GO:0002520~immune system development 5 1.6778523489932886 0.5112046406046497 NM_002198, NM_002221, NM_002211, NM_001983, NM_001018011 97 57 1483 1.341110508229336 1.0 0.9992165309792912 99.99897111731649 GOTERM_BP_FAT GO:0045321~leukocyte activation 5 1.6778523489932886 0.5530285670245331 NM_002198, NM_002221, NM_002211, NM_001983, NM_001956 97 60 1483 1.2740549828178693 1.0 0.9995190875429645 99.99975503668459 GOTERM_BP_FAT GO:0030098~lymphocyte differentiation 3 1.006711409395973 0.5705828227308664 NM_002198, NM_002221, NM_002211 97 29 1483 1.581585495911838 1.0 0.9996484337777961 99.99987119569292 GOTERM_BP_FAT GO:0046649~lymphocyte activation 4 1.342281879194631 0.5825657904737978 NM_002198, NM_002221, NM_002211, NM_001983 97 46 1483 1.3294486777229941 1.0 0.999691763276676 99.99991820476635 GOTERM_BP_FAT GO:0002521~leukocyte differentiation 3 1.006711409395973 0.7044165906692077 NM_002198, NM_002221, NM_002211 97 37 1483 1.2396210643633323 1.0 0.9999596479096565 99.9999996781825 Annotation Cluster 41 Enrichment Score: 0.26988114279571995 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005925~focal adhesion 3 1.006711409395973 0.4270989077500102 NM_022748, NM_002211, NM_003370 72 27 1332 2.0555555555555554 1.0 0.9769322288984028 99.9087175130557 GOTERM_CC_FAT GO:0005924~cell-substrate adherens junction 3 1.006711409395973 0.4457886401264923 NM_022748, NM_002211, NM_003370 72 28 1332 1.982142857142857 1.0 0.9790353580203544 99.93982649629325 GOTERM_CC_FAT GO:0030055~cell-substrate junction 3 1.006711409395973 0.4641450064519168 NM_022748, NM_002211, NM_003370 72 29 1332 1.9137931034482758 1.0 0.9784607661674063 99.96058969834768 GOTERM_CC_FAT GO:0005912~adherens junction 3 1.006711409395973 0.5821303080600124 NM_022748, NM_002211, NM_003370 72 36 1332 1.5416666666666665 1.0 0.9905472003591552 99.99826794647218 GOTERM_CC_FAT GO:0030054~cell junction 5 1.6778523489932886 0.5985405620012403 NM_022748, NM_021954, NM_002211, NM_003370, NM_001097642 72 77 1332 1.2012987012987013 1.0 0.9913522308218323 99.9989529950291 GOTERM_CC_FAT GO:0070161~anchoring junction 3 1.006711409395973 0.6406760790536576 NM_022748, NM_002211, NM_003370 72 40 1332 1.3875 1.0 0.9928957817454669 99.99974004535808 GOTERM_CC_FAT GO:0016323~basolateral plasma membrane 3 1.006711409395973 0.65428739382278 NM_022748, NM_002211, NM_003370 72 41 1332 1.3536585365853657 1.0 0.9925561134262423 99.99983997820782 Annotation Cluster 42 Enrichment Score: 0.2594182581519294 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0044265~cellular macromolecule catabolic process 7 2.348993288590604 0.3807290218399992 NM_003407, NM_001039591, NM_025241, NM_003955, NM_001983, NM_001135592, NM_001018011 97 77 1483 1.3898781630740393 1.0 0.9973821256024292 99.95419194940325 GOTERM_BP_FAT GO:0009057~macromolecule catabolic process 7 2.348993288590604 0.44093039522110905 NM_003407, NM_001039591, NM_025241, NM_003955, NM_001983, NM_001135592, NM_001018011 97 82 1483 1.305129494593915 1.0 0.9983975151865152 99.991121254595 SP_PIR_KEYWORDS ubl conjugation pathway 5 1.6778523489932886 0.4540082011791437 NM_003861, NM_001039591, NM_025241, NM_003955, NM_001018011 121 56 1955 1.4425914994096811 1.0 0.9838202401005732 99.94364722590127 GOTERM_BP_FAT GO:0043632~modification-dependent macromolecule catabolic process 5 1.6778523489932886 0.5530285670245331 NM_001039591, NM_025241, NM_003955, NM_001135592, NM_001018011 97 60 1483 1.2740549828178693 1.0 0.9995190875429645 99.99975503668459 GOTERM_BP_FAT GO:0019941~modification-dependent protein catabolic process 5 1.6778523489932886 0.5530285670245331 NM_001039591, NM_025241, NM_003955, NM_001135592, NM_001018011 97 60 1483 1.2740549828178693 1.0 0.9995190875429645 99.99975503668459 GOTERM_BP_FAT GO:0051603~proteolysis involved in cellular protein catabolic process 5 1.6778523489932886 0.6183992432274534 NM_001039591, NM_025241, NM_003955, NM_001135592, NM_001018011 97 65 1483 1.1760507533703408 1.0 0.9997959847472466 99.99998062001856 GOTERM_BP_FAT GO:0044257~cellular protein catabolic process 5 1.6778523489932886 0.6307551430125153 NM_001039591, NM_025241, NM_003955, NM_001135592, NM_001018011 97 66 1483 1.1582318025616996 1.0 0.9998366335231698 99.99998857099193 GOTERM_BP_FAT GO:0030163~protein catabolic process 5 1.6778523489932886 0.6307551430125153 NM_001039591, NM_025241, NM_003955, NM_001135592, NM_001018011 97 66 1483 1.1582318025616996 1.0 0.9998366335231698 99.99998857099193 GOTERM_BP_FAT GO:0006508~proteolysis 6 2.013422818791946 0.8066781183541429 NM_001039591, NM_025241, NM_003955, NM_007038, NM_001135592, NM_001018011 97 102 1483 0.8993329290479078 1.0 0.9999969737899396 99.99999999964591 Annotation Cluster 43 Enrichment Score: 0.24638789836401165 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051056~regulation of small GTPase mediated signal transduction 5 1.6778523489932886 0.3928572715187449 NM_007368, NM_020979, NM_014869, NM_002221, NM_032552 97 49 1483 1.560067325899432 1.0 0.9978092076995378 99.96664773844044 UP_SEQ_FEATURE domain:PH 5 1.6778523489932886 0.46792870233423806 NM_007368, NM_005544, NM_020979, NM_014869, NM_032552 121 57 1955 1.41728287661302 1.0 0.9999843709552848 99.9872653828891 GOTERM_MF_FAT GO:0060589~nucleoside-triphosphatase regulator activity 6 2.013422818791946 0.5340582701915638 NM_007368, NM_000390, NM_014869, NM_178006, NM_032552, NM_058246 90 77 1425 1.2337662337662336 1.0 0.9999134908203086 99.99493001275732 INTERPRO IPR001849:Pleckstrin homology 5 1.6778523489932886 0.6539983212674784 NM_007368, NM_005544, NM_020979, NM_014869, NM_032552 119 66 1769 1.1261777438248026 1.0 0.9999999999679988 99.99992866528841 GOTERM_MF_FAT GO:0030695~GTPase regulator activity 5 1.6778523489932886 0.7136204105683128 NM_007368, NM_000390, NM_014869, NM_178006, NM_032552 90 76 1425 1.0416666666666665 1.0 0.9999923665075972 99.99999071923055 SMART SM00233:PH 5 1.6778523489932886 0.7254802387193122 NM_007368, NM_005544, NM_020979, NM_014869, NM_032552 82 66 1112 1.0273466371027347 1.0 0.9999989164607858 99.99990884814397 Annotation Cluster 44 Enrichment Score: 0.21537093655699935 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:SH2 3 1.006711409395973 0.5210616501905847 NM_022748, NM_020979, NM_003955 121 28 1955 1.7311097992916176 1.0 0.9999937895204783 99.9971453452996 SP_PIR_KEYWORDS SH2 domain 3 1.006711409395973 0.5947510992165967 NM_022748, NM_020979, NM_003955 121 32 1955 1.5147210743801656 1.0 0.9960733036458373 99.99858619497702 INTERPRO IPR000980:SH2 motif 3 1.006711409395973 0.6416057563860207 NM_022748, NM_020979, NM_003955 119 32 1769 1.3936449579831933 1.0 0.9999999999898241 99.99988594679651 SMART SM00252:SH2 3 1.006711409395973 0.6918686274974974 NM_022748, NM_020979, NM_003955 82 32 1112 1.271341463414634 1.0 0.9999993808536813 99.99968417378017 Annotation Cluster 45 Enrichment Score: 0.2104569353098703 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0044093~positive regulation of molecular function 8 2.684563758389262 0.39670372193304665 NM_145109, NM_006186, NM_005544, NM_001127242, NM_006056, NM_004924, NM_001956, NM_001135592 97 93 1483 1.3151535306507038 1.0 0.9978338464420333 99.96988093345789 GOTERM_BP_FAT GO:0051272~positive regulation of cell motion 3 1.006711409395973 0.6076782602285788 NM_005544, NM_004924, NM_001956 97 31 1483 1.4795477219820419 1.0 0.9997714892307659 99.99996977176846 GOTERM_BP_FAT GO:0051050~positive regulation of transport 3 1.006711409395973 0.7044165906692077 NM_005544, NM_004924, NM_001956 97 37 1483 1.2396210643633323 1.0 0.9999596479096565 99.9999996781825 GOTERM_BP_FAT GO:0051270~regulation of cell motion 3 1.006711409395973 0.8476229516866963 NM_005544, NM_004924, NM_001956 97 50 1483 0.917319587628866 1.0 0.9999991468458724 99.99999999999223 Annotation Cluster 46 Enrichment Score: 0.14852965967676415 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042592~homeostatic process 8 2.684563758389262 0.4849897694949776 NM_013275, NM_005544, NM_001769, NM_201559, NM_020979, NM_001025101, NM_012205, NM_001956, NM_001455 97 101 1483 1.2109829539654997 1.0 0.9989647462685316 99.99762105791034 GOTERM_BP_FAT GO:0048878~chemical homeostasis 5 1.6778523489932886 0.6662958565912995 NM_005544, NM_001769, NM_201559, NM_001025101, NM_001956, NM_001455 97 69 1483 1.1078738981024951 1.0 0.9999219851198937 99.99999774664049 GOTERM_BP_FAT GO:0019725~cellular homeostasis 4 1.342281879194631 0.7047848881715916 NM_001769, NM_001025101, NM_012205, NM_001956 97 55 1483 1.1119025304592316 1.0 0.999956999072067 99.99999968455595 GOTERM_BP_FAT GO:0006873~cellular ion homeostasis 3 1.006711409395973 0.8120207448352645 NM_001769, NM_001025101, NM_001956 97 46 1483 0.9970865082922457 1.0 0.9999970984113578 99.99999999977413 GOTERM_BP_FAT GO:0055082~cellular chemical homeostasis 3 1.006711409395973 0.8120207448352645 NM_001769, NM_001025101, NM_001956 97 46 1483 0.9970865082922457 1.0 0.9999970984113578 99.99999999977413 GOTERM_BP_FAT GO:0050801~ion homeostasis 3 1.006711409395973 0.8555226648935096 NM_001769, NM_001025101, NM_001956 97 51 1483 0.8993329290479078 1.0 0.9999993689107791 99.99999999999669 Annotation Cluster 47 Enrichment Score: 0.1450734264703554 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043085~positive regulation of catalytic activity 7 2.348993288590604 0.35665455911115806 NM_145109, NM_006186, NM_005544, NM_001127242, NM_006056, NM_001956, NM_001135592 97 75 1483 1.4269415807560137 1.0 0.9967327787850923 99.9155332048155 GOTERM_BP_FAT GO:0044093~positive regulation of molecular function 8 2.684563758389262 0.39670372193304665 NM_145109, NM_006186, NM_005544, NM_001127242, NM_006056, NM_004924, NM_001956, NM_001135592 97 93 1483 1.3151535306507038 1.0 0.9978338464420333 99.96988093345789 GOTERM_BP_FAT GO:0007243~protein kinase cascade 5 1.6778523489932886 0.7202898823440416 NM_145109, NM_005544, NM_003407, NM_002221, NM_003955 97 74 1483 1.0330175536361101 1.0 0.999967937556055 99.99999986725882 GOTERM_BP_FAT GO:0051347~positive regulation of transferase activity 3 1.006711409395973 0.7449555589087246 NM_145109, NM_005544, NM_001956 97 40 1483 1.1466494845360826 1.0 0.9999808495833165 99.99999996981674 GOTERM_BP_FAT GO:0033674~positive regulation of kinase activity 3 1.006711409395973 0.7449555589087246 NM_145109, NM_005544, NM_001956 97 40 1483 1.1466494845360826 1.0 0.9999808495833165 99.99999996981674 GOTERM_BP_FAT GO:0043549~regulation of kinase activity 3 1.006711409395973 0.901215102867329 NM_145109, NM_005544, NM_001956 97 58 1483 0.790792747955919 1.0 0.9999999272771904 99.99999999999999 GOTERM_BP_FAT GO:0042325~regulation of phosphorylation 4 1.342281879194631 0.9038132538613486 NM_145109, NM_005544, NM_003955, NM_001956 97 80 1483 0.7644329896907217 1.0 0.999999933226081 100.0 GOTERM_BP_FAT GO:0051338~regulation of transferase activity 3 1.006711409395973 0.9065309848352993 NM_145109, NM_005544, NM_001956 97 59 1483 0.7773894810414118 1.0 0.9999999394816707 100.0 GOTERM_BP_FAT GO:0019220~regulation of phosphate metabolic process 4 1.342281879194631 0.9209730204133763 NM_145109, NM_005544, NM_003955, NM_001956 97 84 1483 0.7280314187530682 1.0 0.9999999791816185 100.0 GOTERM_BP_FAT GO:0051174~regulation of phosphorus metabolic process 4 1.342281879194631 0.9209730204133763 NM_145109, NM_005544, NM_003955, NM_001956 97 84 1483 0.7280314187530682 1.0 0.9999999791816185 100.0 Annotation Cluster 48 Enrichment Score: 0.11961014042251886 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000278~mitotic cell cycle 4 1.342281879194631 0.5515329170590478 NM_002211, NM_001039591, NM_001135592, NM_004523 97 44 1483 1.3898781630740393 1.0 0.9995345972502301 99.9997415493031 GOTERM_BP_FAT GO:0022402~cell cycle process 4 1.342281879194631 0.8385207695709636 NM_002211, NM_001039591, NM_001135592, NM_004523 97 69 1483 0.8862991184819962 1.0 0.9999989041322567 99.99999999998028 GOTERM_BP_FAT GO:0022403~cell cycle phase 3 1.006711409395973 0.8393377513557974 NM_002211, NM_001039591, NM_004523 97 49 1483 0.9360403955396592 1.0 0.9999988445270611 99.99999999998181 GOTERM_BP_FAT GO:0007049~cell cycle 5 1.6778523489932886 0.8561254737206732 NM_004417, NM_002211, NM_001039591, NM_001135592, NM_004523 97 91 1483 0.8400362524073864 1.0 0.9999993285126101 99.9999999999969 Annotation Cluster 49 Enrichment Score: 0.08421090072855117 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005626~insoluble fraction 6 2.013422818791946 0.7444761459181779 NM_001654, NM_005544, NM_201559, NM_002211, NM_006056, NM_005270, NM_001455 72 114 1332 0.9736842105263157 1.0 0.9975735618698301 99.99999641357373 KEGG_PATHWAY hsa05200:Pathways in cancer 4 1.342281879194631 0.7851410436073105 NM_001654, NM_002211, NM_005270, NM_001018011 38 68 631 0.9767801857585139 1.0 0.9999998316830041 99.999988296805 GOTERM_CC_FAT GO:0000267~cell fraction 7 2.348993288590604 0.800262716664242 NM_001654, NM_005544, NM_201559, NM_002211, NM_006056, NM_012205, NM_005270, NM_001455 72 144 1332 0.8993055555555555 1.0 0.9983573197254858 99.99999983759238 GOTERM_CC_FAT GO:0005624~membrane fraction 5 1.6778523489932886 0.8392332756908121 NM_005544, NM_201559, NM_002211, NM_006056, NM_005270, NM_001455 72 107 1332 0.8644859813084114 1.0 0.9989627449082242 99.99999998937723 GOTERM_CC_FAT GO:0005887~integral to plasma membrane 5 1.6778523489932886 0.9661215048163454 NM_005544, NM_001769, NM_001523, NM_002211, NM_006056 72 148 1332 0.6250000000000001 1.0 0.999992842944409 100.0 Annotation Cluster 50 Enrichment Score: 0.07887764906375748 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS protein transport 4 1.342281879194631 0.5741084994923931 NM_015446, NM_004924, NM_024591, NM_003827 121 48 1955 1.3464187327823691 1.0 0.9963359222592821 99.9973869921921 GOTERM_BP_FAT GO:0015031~protein transport 4 1.342281879194631 0.9284744480525728 NM_000390, NM_004924, NM_024591, NM_003827 97 86 1483 0.7111004555262527 1.0 0.999999986999999 100.0 GOTERM_BP_FAT GO:0045184~establishment of protein localization 4 1.342281879194631 0.9319781431291336 NM_000390, NM_004924, NM_024591, NM_003827 97 87 1483 0.702926887071928 1.0 0.9999999885025048 100.0 GOTERM_BP_FAT GO:0008104~protein localization 4 1.342281879194631 0.9734636598135284 NM_000390, NM_004924, NM_024591, NM_003827 97 105 1483 0.5824251350024545 1.0 0.9999999999482431 100.0 Annotation Cluster 51 Enrichment Score: 0.07733048474570588 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043933~macromolecular complex subunit organization 5 1.6778523489932886 0.7202898823440416 NM_005544, NM_015446, NM_139135, NM_207292, NM_001097642 97 74 1483 1.0330175536361101 1.0 0.999967937556055 99.99999986725882 GOTERM_BP_FAT GO:0065003~macromolecular complex assembly 4 1.342281879194631 0.8385207695709636 NM_005544, NM_015446, NM_207292, NM_001097642 97 69 1483 0.8862991184819962 1.0 0.9999989041322567 99.99999999998028 GOTERM_BP_FAT GO:0006461~protein complex assembly 3 1.006711409395973 0.901215102867329 NM_005544, NM_015446, NM_001097642 97 58 1483 0.790792747955919 1.0 0.9999999272771904 99.99999999999999 GOTERM_BP_FAT GO:0070271~protein complex biogenesis 3 1.006711409395973 0.901215102867329 NM_005544, NM_015446, NM_001097642 97 58 1483 0.790792747955919 1.0 0.9999999272771904 99.99999999999999 Annotation Cluster 52 Enrichment Score: 0.0704325652619083 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0046983~protein dimerization activity 5 1.6778523489932886 0.8361337310043008 NM_006186, NM_005194, NM_002211, NM_004924, NM_001018011 90 91 1425 0.8699633699633699 1.0 0.999999031865412 99.99999999327169 GOTERM_MF_FAT GO:0042803~protein homodimerization activity 3 1.006711409395973 0.8490418008290372 NM_005194, NM_004924, NM_001018011 90 52 1425 0.9134615384615385 1.0 0.9999987895745929 99.99999999767472 GOTERM_MF_FAT GO:0042802~identical protein binding 5 1.6778523489932886 0.8659593143764408 NM_021954, NM_005194, NM_002211, NM_004924, NM_001018011 90 96 1425 0.8246527777777778 1.0 0.9999988508929986 99.9999999995011 Annotation Cluster 53 Enrichment Score: 0.060703884046530286 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004713~protein tyrosine kinase activity 4 1.342281879194631 0.30498217108089576 NM_145109, NM_020680, NM_133494, NM_005544 90 31 1425 2.043010752688172 1.0 0.9973741669569439 99.10070721264165 SP_PIR_KEYWORDS serine/threonine-protein kinase 4 1.342281879194631 0.7652297598318551 NM_001654, NM_145109, NM_133494, NM_013302 121 64 1955 1.009814049586777 1.0 0.9991034234574144 99.99999834247744 GOTERM_MF_FAT GO:0004672~protein kinase activity 6 2.013422818791946 0.7880073565241263 NM_001654, NM_145109, NM_020680, NM_133494, NM_005544, NM_013302 90 103 1425 0.9223300970873787 1.0 0.9999979649635391 99.99999981116486 UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 7 2.348993288590604 0.7945795972807485 NM_001654, NM_145109, NM_133494, NM_013302, NM_001042572, NM_002221, NM_004523 121 125 1955 0.904793388429752 1.0 0.9999999998396123 99.99999998301588 SP_PIR_KEYWORDS kinase 6 2.013422818791946 0.8259563989501821 NM_001654, NM_145109, NM_133494, NM_013302, NM_002221, NM_183048 121 111 1955 0.8733526915345097 1.0 0.9996089596798953 99.99999995902714 GOTERM_MF_FAT GO:0004674~protein serine/threonine kinase activity 4 1.342281879194631 0.8489494746572066 NM_001654, NM_145109, NM_133494, NM_013302 90 73 1425 0.8675799086757991 1.0 0.9999991953546432 99.99999999765625 GOTERM_MF_FAT GO:0001882~nucleoside binding 10 3.3557046979865772 0.8710454045215283 NM_001654, NM_145109, NM_020680, NM_133494, NM_013302, NM_001042572, NM_002221, NM_004924, NM_004523, NM_006045 90 192 1425 0.8246527777777778 1.0 0.9999987127905 99.99999999969769 SP_PIR_KEYWORDS atp-binding 8 2.684563758389262 0.8768912943002706 NM_001654, NM_145109, NM_133494, NM_013302, NM_001042572, NM_002221, NM_004523, NM_006045 121 160 1955 0.8078512396694214 1.0 0.9997703031383006 99.99999999943307 GOTERM_MF_FAT GO:0005524~ATP binding 9 3.0201342281879198 0.8808508890460122 NM_001654, NM_145109, NM_020680, NM_133494, NM_013302, NM_001042572, NM_002221, NM_004523, NM_006045 90 176 1425 0.8096590909090909 1.0 0.9999988953694764 99.99999999989143 SP_PIR_KEYWORDS transferase 9 3.0201342281879198 0.8872816852268216 NM_001654, NM_145109, NM_133494, NM_013302, NM_002221, NM_004104, NM_032047, NM_001523, NM_004776 121 182 1955 0.7989737535192081 1.0 0.9998056165577082 99.9999999998094 GOTERM_MF_FAT GO:0032559~adenyl ribonucleotide binding 9 3.0201342281879198 0.8885017762168468 NM_001654, NM_145109, NM_020680, NM_133494, NM_013302, NM_001042572, NM_002221, NM_004523, NM_006045 90 178 1425 0.800561797752809 1.0 0.9999989651238049 99.99999999995404 UP_SEQ_FEATURE domain:Protein kinase 4 1.342281879194631 0.8910601723877503 NM_001654, NM_145109, NM_020680, NM_133494 121 82 1955 0.7881475508969966 1.0 0.9999999999997143 99.99999999999794 GOTERM_BP_FAT GO:0006468~protein amino acid phosphorylation 6 2.013422818791946 0.8913830278940972 NM_001654, NM_145109, NM_020680, NM_133494, NM_013302, NM_032246 97 117 1483 0.7840338355802273 1.0 0.9999998708959589 99.99999999999997 GOTERM_MF_FAT GO:0030554~adenyl nucleotide binding 9 3.0201342281879198 0.9152132769672046 NM_001654, NM_145109, NM_020680, NM_133494, NM_013302, NM_001042572, NM_002221, NM_004523, NM_006045 90 186 1425 0.7661290322580645 1.0 0.9999997270971425 99.99999999999868 UP_SEQ_FEATURE binding site:ATP 4 1.342281879194631 0.9209158619173609 NM_001654, NM_145109, NM_133494, NM_002221 121 89 1955 0.7261584176803788 1.0 0.999999999999989 99.99999999999997 GOTERM_BP_FAT GO:0016310~phosphorylation 6 2.013422818791946 0.9220260292155739 NM_001654, NM_145109, NM_020680, NM_133494, NM_013302, NM_032246 97 125 1483 0.7338556701030928 1.0 0.9999999788543122 100.0 INTERPRO IPR008271:Serine/threonine protein kinase, active site 3 1.006711409395973 0.9240454549683575 NM_001654, NM_145109, NM_133494 119 61 1769 0.73109243697479 1.0 1.0 99.99999999999987 INTERPRO IPR017442:Serine/threonine protein kinase-related 3 1.006711409395973 0.9240454549683575 NM_001654, NM_145109, NM_133494 119 61 1769 0.73109243697479 1.0 1.0 99.99999999999987 GOTERM_MF_FAT GO:0001883~purine nucleoside binding 9 3.0201342281879198 0.926426704073403 NM_001654, NM_145109, NM_020680, NM_133494, NM_013302, NM_001042572, NM_002221, NM_004523, NM_006045 90 190 1425 0.75 1.0 0.999999830970603 99.99999999999979 INTERPRO IPR000719:Protein kinase, core 4 1.342281879194631 0.9295512358602009 NM_001654, NM_145109, NM_020680, NM_133494 119 84 1769 0.7078831532613045 1.0 1.0 99.99999999999996 GOTERM_BP_FAT GO:0006793~phosphorus metabolic process 7 2.348993288590604 0.9297556049088006 NM_001654, NM_145109, NM_020680, NM_004417, NM_133494, NM_013302, NM_032246 97 147 1483 0.7280314187530682 1.0 0.999999987175874 100.0 GOTERM_BP_FAT GO:0006796~phosphate metabolic process 7 2.348993288590604 0.9297556049088006 NM_001654, NM_145109, NM_020680, NM_004417, NM_133494, NM_013302, NM_032246 97 147 1483 0.7280314187530682 1.0 0.999999987175874 100.0 SP_PIR_KEYWORDS nucleotide-binding 8 2.684563758389262 0.9609975773181786 NM_001654, NM_145109, NM_133494, NM_013302, NM_001042572, NM_002221, NM_004523, NM_006045 121 192 1955 0.6732093663911846 1.0 0.9999765183023275 100.0 GOTERM_MF_FAT GO:0032555~purine ribonucleotide binding 9 3.0201342281879198 0.96545435550327 NM_001654, NM_145109, NM_020680, NM_133494, NM_013302, NM_001042572, NM_002221, NM_004523, NM_006045 90 210 1425 0.6785714285714287 1.0 0.9999999927304397 100.0 GOTERM_MF_FAT GO:0032553~ribonucleotide binding 9 3.0201342281879198 0.96545435550327 NM_001654, NM_145109, NM_020680, NM_133494, NM_013302, NM_001042572, NM_002221, NM_004523, NM_006045 90 210 1425 0.6785714285714287 1.0 0.9999999927304397 100.0 GOTERM_MF_FAT GO:0000166~nucleotide binding 11 3.691275167785235 0.9701686808373888 NM_001654, NM_145109, NM_020680, NM_015001, NM_133494, NM_013302, NM_017446, NM_001042572, NM_002221, NM_004523, NM_006045 90 253 1425 0.6884057971014492 1.0 0.9999999950404881 100.0 GOTERM_MF_FAT GO:0017076~purine nucleotide binding 9 3.0201342281879198 0.9749935164492031 NM_001654, NM_145109, NM_020680, NM_133494, NM_013302, NM_001042572, NM_002221, NM_004523, NM_006045 90 218 1425 0.6536697247706422 1.0 0.9999999970631012 100.0 INTERPRO IPR017441:Protein kinase, ATP binding site 3 1.006711409395973 0.9754685717883392 NM_001654, NM_145109, NM_133494 119 80 1769 0.5574579831932773 1.0 1.0 100.0 UP_SEQ_FEATURE active site:Proton acceptor 3 1.006711409395973 0.9851266822267511 NM_001654, NM_145109, NM_133494 121 96 1955 0.5049070247933884 1.0 1.0 100.0 Annotation Cluster 54 Enrichment Score: 0.06005118823505248 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005794~Golgi apparatus 6 2.013422818791946 0.8314462968767233 NM_020680, NM_004104, NM_032047, NM_004176, NM_003827, NM_004776 72 128 1332 0.8671875 1.0 0.9989079015657183 99.99999998075404 UP_SEQ_FEATURE topological domain:Lumenal 3 1.006711409395973 0.8821447400576485 NM_032047, NM_004176, NM_004776 121 58 1955 0.8357081789683671 1.0 0.9999999999996492 99.99999999999368 SP_PIR_KEYWORDS golgi apparatus 4 1.342281879194631 0.9004764992046401 NM_020680, NM_032047, NM_004176, NM_004776 121 84 1955 0.7693821330184967 1.0 0.9997947106732024 99.9999999999591 Annotation Cluster 55 Enrichment Score: 0.035853269614635835 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS cell membrane 12 4.026845637583892 0.8914360402356176 NM_181481, NM_007368, NM_020979, NM_021954, NM_001025101, NM_133337, NM_002211, NM_024522, NM_006056, NM_020370, NM_003370, NM_001097642 121 240 1955 0.8078512396694215 1.0 0.9997607228034402 99.9999999998802 GOTERM_CC_FAT GO:0044459~plasma membrane part 13 4.3624161073825505 0.9110901263360769 NM_022748, NM_007368, NM_005544, NM_001769, NM_021954, NM_002211, NM_001627, NM_003370, NM_001097642, NM_178006, NM_001025101, NM_001523, NM_006056 72 301 1332 0.7990033222591363 1.0 0.9998679708052031 99.99999999999378 GOTERM_CC_FAT GO:0005886~plasma membrane 20 6.7114093959731544 0.9611444503119355 NM_022748, NM_007368, NM_005544, NM_001769, NM_032250, NM_020979, NM_021954, NM_002211, NM_001627, NM_003370, NM_001097642, NM_001018011, NM_181481, NM_001025101, NM_178006, NM_001523, NM_024522, NM_133337, NM_006056, NM_020370 72 475 1332 0.7789473684210527 1.0 0.9999905273134032 100.0 Annotation Cluster 56 Enrichment Score: 0.02547071286856655 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0031226~intrinsic to plasma membrane 6 2.013422818791946 0.91907640587564 NM_007368, NM_005544, NM_001769, NM_001523, NM_002211, NM_006056 72 150 1332 0.74 1.0 0.999889903765233 99.9999999999981 GOTERM_BP_FAT GO:0007155~cell adhesion 5 1.6778523489932886 0.9435268924180495 NM_001769, NM_001523, NM_002211, NM_001627, NM_005524 97 112 1483 0.6825294550810014 1.0 0.9999999959066493 100.0 GOTERM_BP_FAT GO:0022610~biological adhesion 5 1.6778523489932886 0.9435268924180495 NM_001769, NM_001523, NM_002211, NM_001627, NM_005524 97 112 1483 0.6825294550810014 1.0 0.9999999959066493 100.0 SP_PIR_KEYWORDS cell adhesion 3 1.006711409395973 0.9435273713562672 NM_001769, NM_002211, NM_001627 121 72 1955 0.6732093663911847 1.0 0.9999441525218137 99.99999999999997 GOTERM_CC_FAT GO:0005887~integral to plasma membrane 5 1.6778523489932886 0.9661215048163454 NM_005544, NM_001769, NM_001523, NM_002211, NM_006056 72 148 1332 0.6250000000000001 1.0 0.999992842944409 100.0 Annotation Cluster 57 Enrichment Score: 0.020846434687595315 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0031224~intrinsic to membrane 28 9.395973154362416 0.7723883985911807 NM_007368, NM_005544, NM_032047, NM_001097642, NM_181481, NM_020796, NM_015446, NM_001126122, NM_133337, NM_006056, NM_020370, NM_004776, NM_001769, NM_021954, NM_002211, NM_004176, NM_001015881, NM_001627, NM_024591, NM_021814, NM_016354, NM_080872, NM_001130721, NM_024522, NM_001523, NM_001143780, NM_012401, NM_006045 72 554 1332 0.9350180505415162 1.0 0.9978275579261245 99.99999916158791 GOTERM_CC_FAT GO:0016021~integral to membrane 26 8.724832214765101 0.8281294790609024 NM_005544, NM_032047, NM_001097642, NM_181481, NM_020796, NM_015446, NM_001126122, NM_133337, NM_006056, NM_020370, NM_004776, NM_001769, NM_021954, NM_002211, NM_004176, NM_001015881, NM_001627, NM_021814, NM_016354, NM_080872, NM_001130721, NM_024522, NM_001523, NM_001143780, NM_012401, NM_006045 72 531 1332 0.9058380414312618 1.0 0.9989664204669522 99.99999997541477 UP_SEQ_FEATURE topological domain:Extracellular 14 4.697986577181208 0.9507500707673209 NM_001769, NM_021954, NM_002211, NM_001627, NM_001097642, NM_181481, NM_020796, NM_080872, NM_133337, NM_001523, NM_006056, NM_020370, NM_012401, NM_006045 121 304 1955 0.7440735102218357 1.0 0.9999999999999999 100.0 UP_SEQ_FEATURE transmembrane region 24 8.053691275167784 0.961597558009424 NM_001769, NM_021954, NM_032047, NM_004176, NM_002211, NM_001015881, NM_001627, NM_021814, NM_001097642, NM_181481, NM_016354, NM_020796, NM_080872, NM_001126122, NM_001130721, NM_001523, NM_133337, NM_024522, NM_006056, NM_020370, NM_004776, NM_001143780, NM_006045, NM_012401 121 497 1955 0.7802185010891797 1.0 1.0 100.0 SP_PIR_KEYWORDS transmembrane 24 8.053691275167784 0.9646969393440522 NM_001769, NM_021954, NM_032047, NM_004176, NM_002211, NM_001015881, NM_001627, NM_021814, NM_001097642, NM_181481, NM_016354, NM_020796, NM_080872, NM_001126122, NM_001130721, NM_001523, NM_133337, NM_024522, NM_006056, NM_020370, NM_004776, NM_001143780, NM_006045, NM_012401 121 500 1955 0.7755371900826447 1.0 0.9999794772106931 100.0 UP_SEQ_FEATURE topological domain:Cytoplasmic 17 5.704697986577181 0.968422393979913 NM_001769, NM_021954, NM_032047, NM_002211, NM_004176, NM_001627, NM_001097642, NM_181481, NM_020796, NM_080872, NM_001523, NM_133337, NM_006056, NM_020370, NM_004776, NM_012401, NM_006045 121 375 1955 0.7324517906336089 1.0 1.0 100.0 SP_PIR_KEYWORDS membrane 32 10.738255033557047 0.9902982439457373 NM_007368, NM_032047, NM_003370, NM_001097642, NM_181481, NM_020796, NM_001126122, NM_001025101, NM_133337, NM_006056, NM_020370, NM_003827, NM_004776, NM_001769, NM_020979, NM_021954, NM_004176, NM_002211, NM_001015881, NM_001627, NM_024591, NM_021814, NM_016354, NM_080872, NM_001130721, NM_178006, NM_001523, NM_024522, NM_032552, NM_006045, NM_001143780, NM_012401 121 686 1955 0.7536804568344457 1.0 0.9999989395471535 100.0 SP_PIR_KEYWORDS disulfide bond 11 3.691275167785235 0.9947781277781181 NM_181481, NM_020796, NM_001769, NM_001135101, NM_080872, NM_002211, NM_006056, NM_001627, NM_004776, NM_007038, NM_001956 121 305 1955 0.5827123695976155 1.0 0.9999997839254471 100.0 UP_SEQ_FEATURE disulfide bond 10 3.3557046979865772 0.9958635571026572 NM_181481, NM_020796, NM_001135101, NM_080872, NM_002211, NM_006056, NM_001627, NM_004776, NM_007038, NM_001956 121 289 1955 0.5590666018473505 1.0 1.0 100.0 SP_PIR_KEYWORDS glycoprotein 15 5.033557046979865 0.9998373669374868 NM_016734, NM_001769, NM_001135101, NM_032047, NM_002211, NM_001627, NM_007038, NM_020796, NM_016354, NM_080872, NM_024522, NM_006056, NM_020370, NM_004776, NM_012401 121 467 1955 0.5189622524642965 1.0 0.9999999999871996 100.0 UP_SEQ_FEATURE glycosylation site:N-linked (GlcNAc...) 14 4.697986577181208 0.999854136108692 NM_001135101, NM_001769, NM_002211, NM_032047, NM_001627, NM_007038, NM_020796, NM_016354, NM_080872, NM_024522, NM_006056, NM_020370, NM_004776, NM_012401 121 448 1955 0.5049070247933884 1.0 1.0 100.0 UP_SEQ_FEATURE signal peptide 8 2.684563758389262 0.9999871426996773 NM_020796, NM_001135101, NM_080872, NM_002211, NM_001627, NM_007038, NM_001956, NM_012401 121 355 1955 0.3641019671749506 1.0 1.0 100.0 SP_PIR_KEYWORDS signal 8 2.684563758389262 0.9999871426996773 NM_020796, NM_001135101, NM_080872, NM_002211, NM_001627, NM_007038, NM_001956, NM_012401 121 355 1955 0.3641019671749506 1.0 0.9999999999999768 100.0