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Fig. 3. Evidence for linkage between D6S1053 and the quantitative score for cortical cataracts. The multipoint identity by descent (IBD) sharing scores estimated using GENIBD (x axis) were plotted against the weighted average of the squared trait difference and the squared mean-corrected trait sum, allowing for the non-independence of the sib pairs (y axis). The scale for IBD scores ranged from 0 to 1 but can be interpreted as corresponding to 0, 1, and 2 alleles IBD (x axis). The positive slope of the regression line demonstrates that there is strong evidence for linkage at this position.

Fig. 4. Increase in evidence of linkage using a reordered map. (Upper) Original map obtained from the Human Genome Server was used to perform linkage. (Lower) Markers were rearranged to minimize the difference in the identity by descent sharing at neighboring markers. A table listing the rearranged markers is also provided (see Table 3).

Markers in bold are fine mapping markers. Changes in order of markers are indicated by italicizing the marker.