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{"sheet":"S1","index":0,"n_rows":189,"n_cols":1,"rows_kept":189,"cut":false,"hidden":false,"merged":[]}
["Table S1. Compounds in the Gray Kinase collection"]
["Compound"]
["ALW-I-16-4"]
["ALW-I-17-14"]
["ALW-I-17-16"]
["ALW-I-17-20"]
["ALW-I-40-11"]
["ALW-I-40-4"]
["ALW-I-40-8"]
["ALW-I-40-9"]
["ALW-I-42-3"]
["ALW-I-43-1"]
["ALW-I-43-3"]
["ALW-I-49-1"]
["ALW-I-62-16"]
["ALW-I-62-17"]
["ALW-I-62-20"]
["ALW-I-62-22"]
["ALW-I-62-23"]
["ALW-I-62-24"]
["ALW-I-62-25"]
["ALW-I-62-26"]
["ALW-II-31-1"]
["ALW-II-31-2"]
["ALW-II-36-1"]
["ALW-II-36-2"]
["ALW-II-36-3"]
["ALW-II-37-1"]
["ALW-II-37-2"]
["ALW-II-37-3"]
["ALW-II-38-1"]
["ALW-II-38-2"]
["ALW-II-41-1"]
["ALW-II-41-10"]
["ALW-II-41-13"]
["ALW-II-41-14"]
["ALW-II-41-16"]
["ALW-II-41-17"]
["ALW-II-41-19"]
["ALW-II-41-20"]
["ALW-II-41-21"]
["ALW-II-41-27"]
["ALW-II-41-4"]
["ALW-II-46-10"]
["ALW-II-46-11"]
["ALW-II-46-19"]
["ALW-II-46-26"]
["ALW-II-46-27"]
["ALW-II-46-4"]
["ALW-II-46-5"]
["ALW-II-46-7"]
["ALW-II-46-8"]
["ALW-II-46-9"]
["ALW-II-49-10d"]
["ALW-II-49-2"]
["ALW-II-49-8"]
["ALW-II-50-1"]
["ALW-II-57-1"]
["ALW-II-57-2"]
["AMY001-009"]
["AMY001-021"]
["CGP60474"]
["CVM-04-044"]
["CVM-04-060"]
["CVM-04-069-1"]
["CVM-04-069-2"]
["CVM-04-080"]
["CVM-04-089"]
["CVM-04-115"]
["CVM-04-124-1"]
["CVM-04-124-3"]
["CVM-04-133-1"]
["CVM-04-45"]
["CVM-04-70"]
["CVM-04-82"]
["CVM-04-93"]
["CVM-05-001"]
["CVM-05-056"]
["CVM-05-84"]
["CVM-05-85"]
["CVM-5-004"]
["CVM-5-31"]
["HG-1-90-01"]
["HG-1-92-01"]
["HG-2-100-01"]
["HG-3-39-01"]
["HG-7-26-01"]
["HG-7-27-01"]
["KANG-201c"]
["KANG-201d"]
["KANG-202c"]
["KANG-202d"]
["KANG-203a"]
["KANG-203c"]
["KANG-203d"]
["KANG-204a"]
["KANG-205a"]
["KANG-205c"]
["KANG-205d"]
["KANG-206a"]
["KANG-206d"]
["KANG201A"]
["KANG202A"]
["KANG204D"]
["KIN001-005"]
["KIN001-006"]
["KIN001-009"]
["KIN001-010"]
["KIN001-011"]
["KIN001-012"]
["KIN001-013"]
["KIN001-021"]
["KIN001-024"]
["KIN001-032"]
["KIN001-033"]
["KIN001-038"]
["KIN001-041"]
["KIN001-046"]
["KIN001-047"]
["KIN001-052"]
["KIN001-057"]
["KIN001-063"]
["KIN001-064"]
["KIN001-074"]
["KIN001-119"]
["KIN001-128"]
["KIN001-133"]
["KIN001-139"]
["KIN001-143"]
["KIN001-151"]
["KIN001-152"]
["KIN001-153"]
["KIN001-156"]
["KIN001-158"]
["KIN001-160"]
["NG-X-113"]
["QL-III-34"]
["REN-A-77-1"]
["REN-A-79"]
["REN-A-93"]
["SJKIII101A"]
["SJKIII101B"]
["WZ3026"]
["WZ3102"]
["WZ3105"]
["WZ4016"]
["WZ4066"]
["WZ4094"]
["WZ4099"]
["WZ4103"]
["WZ4105"]
["WZ4118"]
["WZ4140"]
["WZ4141"]
["WZ5084"]
["WZ6044"]
["WZ6076"]
["WZ6083"]
["WZ6108"]
["WZ6148"]
["XMD11-85a"]
["XMD11-85b"]
["XMD11-85c"]
["XMD11-85d"]
["XMD11-85e"]
["XMD11-85f"]
["XMD11-85g"]
["XMD11-85h"]
["XMD3-123"]
["XMD3-146"]
["XMD3-150"]
["XMD7-1"]
["XMD7-113"]
["XMD7-2"]
["XMD7-27"]
["XW-1-145-5"]
["XW-I-57"]
["YD48"]
["YII-114"]
["YT101"]
["YT103"]
["YT107"]
["YT113B"]
["YT119"]
["YT137"]
["YT143"]
["YT151"]
["YT159"]
["YT93A"]

{"sheet":"S2","index":1,"n_rows":43,"n_cols":2,"rows_kept":43,"cut":false,"hidden":false,"merged":[]}
["Table S2. Comounds excluded for cytotoxicity. "]
["Compound"]
["ALW-I-43-1",{"$f":"IF('[1]2043'!C116=\"X\",'[1]2043'!AM116,\"\")","v":""}]
["ALW-II-41-1",{"$f":"IF('[1]2043'!C210=\"X\",'[1]2043'!AM210,\"\")","v":""}]
["ALW-II-41-13",{"$f":"IF('[1]2043'!C242=\"X\",'[1]2043'!AM242,\"\")","v":""}]
["ALW-II-41-14",{"$f":"IF('[1]2043'!C244=\"X\",'[1]2043'!AM244,\"\")","v":""}]
["ALW-II-41-27",{"$f":"IF('[1]2043'!C170=\"X\",'[1]2043'!AM170,\"\")","v":""}]
["ALW-II-46-11",{"$f":"IF('[1]2043'!C294=\"X\",'[1]2043'!AM294,\"\")","v":""}]
["ALW-II-46-26",{"$f":"IF('[1]2043'!C298=\"X\",'[1]2043'!AM298,\"\")","v":""}]
["ALW-II-46-9",{"$f":"IF('[1]2043'!C290=\"X\",'[1]2043'!AM290,\"\")","v":""}]
["ALW-II-57-2",{"$f":"IF('[1]2043'!C338=\"X\",'[1]2043'!AM338,\"\")","v":""}]
["AMY001-021",{"$f":"IF('[1]2043'!C12=\"X\",'[1]2043'!AM12,\"\")","v":""}]
["CGP60474",{"$f":"IF('[1]2043'!C6=\"X\",'[1]2043'!AM6,\"\")","v":""}]
["CVM-04-044",{"$f":"IF('[1]2043'!C74=\"X\",'[1]2043'!AM74,\"\")","v":""}]
["HG-7-26-01",{"$f":"IF('[1]2043'!C46=\"X\",'[1]2043'!AM46,\"\")","v":""}]
["KIN001-005",{"$f":"IF('[1]2043'!C318=\"X\",'[1]2043'!AM318,\"\")","v":""}]
["KIN001-006",{"$f":"IF('[1]2043'!C320=\"X\",'[1]2043'!AM320,\"\")","v":""}]
["KIN001-009",{"$f":"IF('[1]2043'!C322=\"X\",'[1]2043'!AM322,\"\")","v":""}]
["KIN001-038",{"$f":"IF('[1]2043'!C366=\"X\",'[1]2043'!AM366,\"\")","v":""}]
["KIN001-057",{"$f":"IF('[1]2043'!C376=\"X\",'[1]2043'!AM376,\"\")","v":""}]
["KIN001-119",{"$f":"IF('[1]2043'!C3=\"X\",'[1]2043'!AM3,\"\")","v":""}]
["KIN001-128",{"$f":"IF('[1]2043'!C5=\"X\",'[1]2043'!AM5,\"\")","v":""}]
["KIN001-139",{"$f":"IF('[1]2043'!C9=\"X\",'[1]2043'!AM9,\"\")","v":""}]
["KIN001-143",{"$f":"IF('[1]2043'!C11=\"X\",'[1]2043'!AM11,\"\")","v":""}]
["KIN001-151",{"$f":"IF('[1]2043'!C13=\"X\",'[1]2043'!AM13,\"\")","v":""}]
["KIN001-152",{"$f":"IF('[1]2043'!C15=\"X\",'[1]2043'!AM15,\"\")","v":""}]
["KIN001-153",{"$f":"IF('[1]2043'!C17=\"X\",'[1]2043'!AM17,\"\")","v":""}]
["KIN001-158",{"$f":"IF('[1]2043'!C21=\"X\",'[1]2043'!AM21,\"\")","v":""}]
["KIN001-160",{"$f":"IF('[1]2043'!C23=\"X\",'[1]2043'!AM23,\"\")","v":""}]
["QL-III-34",{"$f":"IF('[1]2043'!C142=\"X\",'[1]2043'!AM142,\"\")","v":""}]
["REN-A-77-1",{"$f":"IF('[1]2043'!C4=\"X\",'[1]2043'!AM4,\"\")","v":""}]
["REN-A-93",{"$f":"IF('[1]2043'!C52=\"X\",'[1]2043'!AM52,\"\")","v":""}]
["WZ3102",{"$f":"IF('[1]2043'!C230=\"X\",'[1]2043'!AM230,\"\")","v":""}]
["WZ3105",{"$f":"IF('[1]2043'!C232=\"X\",'[1]2043'!AM232,\"\")","v":""}]
["WZ6148",{"$f":"IF('[1]2043'!C314=\"X\",'[1]2043'!AM314,\"\")","v":""}]
["XMD11-85c",{"$f":"IF('[1]2043'!C190=\"X\",'[1]2043'!AM190,\"\")","v":""}]
["XMD11-85e",{"$f":"IF('[1]2043'!C220=\"X\",'[1]2043'!AM220,\"\")","v":""}]
["XW-I-57",{"$f":"IF('[1]2043'!C16=\"X\",'[1]2043'!AM16,\"\")","v":""}]
["YII-114",{"$f":"IF('[1]2043'!C20=\"X\",'[1]2043'!AM20,\"\")","v":""}]
["YT101",{"$f":"IF('[1]2043'!C60=\"X\",'[1]2043'!AM60,\"\")","v":""}]
["YT107",{"$f":"IF('[1]2043'!C54=\"X\",'[1]2043'!AM54,\"\")","v":""}]
["YT151",{"$f":"IF('[1]2043'!C14=\"X\",'[1]2043'!AM14,\"\")","v":""}]
["YT93A",{"$f":"IF('[1]2043'!C50=\"X\",'[1]2043'!AM50,\"\")","v":""}]

{"sheet":"S3","index":2,"n_rows":148,"n_cols":2,"rows_kept":148,"cut":false,"hidden":false,"merged":[]}
["Table S3. Compounds assigned z-scores."]
["Compound","z-score"]
["SJKIII101B",{"$f":"IF('[1]2043'!C8=\"X\",'[1]2043'!AM8,\"\")","v":1.7024149343320159}]
["WZ4094",{"$f":"IF('[1]2043'!C238=\"X\",'[1]2043'!AM238,\"\")","v":1.5914970324555897}]
["XMD11-85f",{"$f":"IF('[1]2043'!C222=\"X\",'[1]2043'!AM222,\"\")","v":1.5041452411809668}]
["KIN001-063",{"$f":"IF('[1]2043'!C378=\"X\",'[1]2043'!AM378,\"\")","v":1.4937709336689053}]
["XMD11-85g",{"$f":"IF('[1]2043'!C224=\"X\",'[1]2043'!AM224,\"\")","v":1.4833423775944343}]
["WZ4103",{"$f":"IF('[1]2043'!C268=\"X\",'[1]2043'!AM268,\"\")","v":1.3168819187319631}]
["CVM-04-115",{"$f":"IF('[1]2043'!C122=\"X\",'[1]2043'!AM122,\"\")","v":1.3147764003927911}]
["XMD11-85h",{"$f":"IF('[1]2043'!C226=\"X\",'[1]2043'!AM226,\"\")","v":1.2756141421473646}]
["XMD3-150",{"$f":"IF('[1]2043'!C184=\"X\",'[1]2043'!AM184,\"\")","v":1.1704336159270887}]
["SJKIII101A",{"$f":"IF('[1]2043'!C140=\"X\",'[1]2043'!AM140,\"\")","v":1.1399171113649085}]
["KIN001-032",{"$f":"IF('[1]2043'!C362=\"X\",'[1]2043'!AM362,\"\")","v":1.0936705078727225}]
["HG-7-27-01",{"$f":"IF('[1]2043'!C316=\"X\",'[1]2043'!AM316,\"\")","v":1.0838109172915926}]
["CVM-05-84",{"$f":"IF('[1]2043'!C94=\"X\",'[1]2043'!AM94,\"\")","v":1.0761255614216318}]
["WZ4118",{"$f":"IF('[1]2043'!C272=\"X\",'[1]2043'!AM272,\"\")","v":1.0485232521037964}]
["YT103",{"$f":"IF('[1]2043'!C62=\"X\",'[1]2043'!AM62,\"\")","v":1.0483952533297665}]
["ALW-I-62-25",{"$f":"IF('[1]2043'!C160=\"X\",'[1]2043'!AM160,\"\")","v":1.0232254813519222}]
["WZ4016",{"$f":"IF('[1]2043'!C234=\"X\",'[1]2043'!AM234,\"\")","v":0.99412614858167114}]
["WZ4105",{"$f":"IF('[1]2043'!C270=\"X\",'[1]2043'!AM270,\"\")","v":0.93246107750234353}]
["XW-1-145-5",{"$f":"IF('[1]2043'!C10=\"X\",'[1]2043'!AM10,\"\")","v":0.9119537134496043}]
["WZ4066",{"$f":"IF('[1]2043'!C236=\"X\",'[1]2043'!AM236,\"\")","v":0.89449481912442996}]
["KIN001-133",{"$f":"IF('[1]2043'!C7=\"X\",'[1]2043'!AM7,\"\")","v":0.86720433797107521}]
["XMD11-85b",{"$f":"IF('[1]2043'!C188=\"X\",'[1]2043'!AM188,\"\")","v":0.8667285491781016}]
["ALW-II-36-1",{"$f":"IF('[1]2043'!C194=\"X\",'[1]2043'!AM194,\"\")","v":0.83072030397280072}]
["ALW-I-49-1",{"$f":"IF('[1]2043'!C146=\"X\",'[1]2043'!AM146,\"\")","v":0.83021289347436766}]
["AMY001-009",{"$f":"IF('[1]2043'!C2=\"X\",'[1]2043'!AM2,\"\")","v":0.79954215696443764}]
["CVM-04-82",{"$f":"IF('[1]2043'!C90=\"X\",'[1]2043'!AM90,\"\")","v":0.79883992272442683}]
["XMD11-85d",{"$f":"IF('[1]2043'!C218=\"X\",'[1]2043'!AM218,\"\")","v":0.78933558290882433}]
["CVM-5-004",{"$f":"IF('[1]2043'!C124=\"X\",'[1]2043'!AM124,\"\")","v":0.77709651308402539}]
["WZ6108",{"$f":"IF('[1]2043'!C286=\"X\",'[1]2043'!AM286,\"\")","v":0.77357142552578972}]
["YT143",{"$f":"IF('[1]2043'!C68=\"X\",'[1]2043'!AM68,\"\")","v":0.74565133933856675}]
["ALW-II-36-3",{"$f":"IF('[1]2043'!C198=\"X\",'[1]2043'!AM198,\"\")","v":0.74490764147505972}]
["ALW-I-62-20",{"$f":"IF('[1]2043'!C152=\"X\",'[1]2043'!AM152,\"\")","v":0.73332218087733214}]
["KIN001-064",{"$f":"IF('[1]2043'!C380=\"X\",'[1]2043'!AM380,\"\")","v":0.72882510229694342}]
["KIN001-033",{"$f":"IF('[1]2043'!C364=\"X\",'[1]2043'!AM364,\"\")","v":0.72788038937390132}]
["XMD11-85a",{"$f":"IF('[1]2043'!C186=\"X\",'[1]2043'!AM186,\"\")","v":0.7090366379531059}]
["KANG-206a",{"$f":"IF('[1]2043'!C34=\"X\",'[1]2043'!AM34,\"\")","v":0.67546209074601782}]
["YT137",{"$f":"IF('[1]2043'!C66=\"X\",'[1]2043'!AM66,\"\")","v":0.66295587527840194}]
["KANG204D",{"$f":"IF('[1]2043'!C26=\"X\",'[1]2043'!AM26,\"\")","v":0.65177162313108417}]
["YT113B",{"$f":"IF('[1]2043'!C58=\"X\",'[1]2043'!AM58,\"\")","v":0.6152409340461128}]
["CVM-04-069-1",{"$f":"IF('[1]2043'!C78=\"X\",'[1]2043'!AM78,\"\")","v":0.54281553264383398}]
["HG-1-92-01",{"$f":"IF('[1]2043'!C40=\"X\",'[1]2043'!AM40,\"\")","v":0.50829887781398131}]
["ALW-II-36-2",{"$f":"IF('[1]2043'!C196=\"X\",'[1]2043'!AM196,\"\")","v":0.47741320759597877}]
["HG-1-90-01",{"$f":"IF('[1]2043'!C38=\"X\",'[1]2043'!AM38,\"\")","v":0.46526685454356731}]
["CVM-05-056",{"$f":"IF('[1]2043'!C130=\"X\",'[1]2043'!AM130,\"\")","v":0.3851753281562687}]
["WZ4099",{"$f":"IF('[1]2043'!C266=\"X\",'[1]2043'!AM266,\"\")","v":0.36055120867604634}]
["NG-X-113",{"$f":"IF('[1]2043'!C22=\"X\",'[1]2043'!AM22,\"\")","v":0.32152942385505884}]
["CVM-05-001",{"$f":"IF('[1]2043'!C92=\"X\",'[1]2043'!AM92,\"\")","v":0.31457398294505134}]
["KIN001-012",{"$f":"IF('[1]2043'!C328=\"X\",'[1]2043'!AM328,\"\")","v":0.30541625040423265}]
["CVM-04-93",{"$f":"IF('[1]2043'!C88=\"X\",'[1]2043'!AM88,\"\")","v":0.29974224077034795}]
["YT119",{"$f":"IF('[1]2043'!C70=\"X\",'[1]2043'!AM70,\"\")","v":0.27674482594928662}]
["CVM-04-089",{"$f":"IF('[1]2043'!C128=\"X\",'[1]2043'!AM128,\"\")","v":0.2398681718956665}]
["CVM-04-133-1",{"$f":"IF('[1]2043'!C136=\"X\",'[1]2043'!AM136,\"\")","v":0.23071744406667272}]
["CVM-04-70",{"$f":"IF('[1]2043'!C126=\"X\",'[1]2043'!AM126,\"\")","v":0.20531954402562441}]
["REN-A-79",{"$f":"IF('[1]2043'!C64=\"X\",'[1]2043'!AM64,\"\")","v":0.19076625194967306}]
["KIN001-074",{"$f":"IF('[1]2043'!C382=\"X\",'[1]2043'!AM382,\"\")","v":0.17571391240937784}]
["ALW-II-38-2",{"$f":"IF('[1]2043'!C208=\"X\",'[1]2043'!AM208,\"\")","v":0.16321813982284286}]
["CVM-5-31",{"$f":"IF('[1]2043'!C138=\"X\",'[1]2043'!AM138,\"\")","v":0.14456336987230151}]
["WZ6076",{"$f":"IF('[1]2043'!C282=\"X\",'[1]2043'!AM282,\"\")","v":0.10837017634621054}]
["KANG-206d",{"$f":"IF('[1]2043'!C36=\"X\",'[1]2043'!AM36,\"\")","v":0.10803222551816043}]
["CVM-04-080",{"$f":"IF('[1]2043'!C82=\"X\",'[1]2043'!AM82,\"\")","v":0.10431832039171458}]
["ALW-I-16-4",{"$f":"IF('[1]2043'!C98=\"X\",'[1]2043'!AM98,\"\")","v":8.5056902856537553E-2}]
["WZ6044",{"$f":"IF('[1]2043'!C280=\"X\",'[1]2043'!AM280,\"\")","v":7.9561460064089082E-2}]
["ALW-II-50-1",{"$f":"IF('[1]2043'!C308=\"X\",'[1]2043'!AM308,\"\")","v":4.9829648088429407E-2}]
["ALW-I-17-20",{"$f":"IF('[1]2043'!C104=\"X\",'[1]2043'!AM104,\"\")","v":2.7421301434413996E-2}]
["ALW-I-40-4",{"$f":"IF('[1]2043'!C106=\"X\",'[1]2043'!AM106,\"\")","v":2.392762754544718E-2}]
["CVM-04-060",{"$f":"IF('[1]2043'!C76=\"X\",'[1]2043'!AM76,\"\")","v":5.8491986076930381E-3}]
["KIN001-021",{"$f":"IF('[1]2043'!C332=\"X\",'[1]2043'!AM332,\"\")","v":-7.9643005124862554E-3}]
["KANG-202d",{"$f":"IF('[1]2043'!C350=\"X\",'[1]2043'!AM350,\"\")","v":-1.4038616657221836E-2}]
["YT159",{"$f":"IF('[1]2043'!C18=\"X\",'[1]2043'!AM18,\"\")","v":-1.4674554621643618E-2}]
["HG-2-100-01",{"$f":"IF('[1]2043'!C42=\"X\",'[1]2043'!AM42,\"\")","v":-1.8139795149016168E-2}]
["CVM-04-124-1",{"$f":"IF('[1]2043'!C84=\"X\",'[1]2043'!AM84,\"\")","v":-2.470961359446136E-2}]
["WZ4140",{"$f":"IF('[1]2043'!C274=\"X\",'[1]2043'!AM274,\"\")","v":-3.4179393164628827E-2}]
["KIN001-041",{"$f":"IF('[1]2043'!C368=\"X\",'[1]2043'!AM368,\"\")","v":-4.9922333296348542E-2}]
["ALW-II-41-21",{"$f":"IF('[1]2043'!C254=\"X\",'[1]2043'!AM254,\"\")","v":-5.5943951051654429E-2}]
["HG-3-39-01",{"$f":"IF('[1]2043'!C44=\"X\",'[1]2043'!AM44,\"\")","v":-8.1083286584205494E-2}]
["CVM-04-45",{"$f":"IF('[1]2043'!C86=\"X\",'[1]2043'!AM86,\"\")","v":-9.0097084850565598E-2}]
["ALW-I-42-3",{"$f":"IF('[1]2043'!C114=\"X\",'[1]2043'!AM114,\"\")","v":-0.10492422153376339}]
["WZ6083",{"$f":"IF('[1]2043'!C284=\"X\",'[1]2043'!AM284,\"\")","v":-0.10639001861349556}]
["ALW-I-62-17",{"$f":"IF('[1]2043'!C150=\"X\",'[1]2043'!AM150,\"\")","v":-0.10750279095654473}]
["KIN001-011",{"$f":"IF('[1]2043'!C326=\"X\",'[1]2043'!AM326,\"\")","v":-0.11111142534110642}]
["ALW-I-17-14",{"$f":"IF('[1]2043'!C100=\"X\",'[1]2043'!AM100,\"\")","v":-0.14112302849095712}]
["KIN001-046",{"$f":"IF('[1]2043'!C370=\"X\",'[1]2043'!AM370,\"\")","v":-0.14298927037794151}]
["KANG-205c",{"$f":"IF('[1]2043'!C30=\"X\",'[1]2043'!AM30,\"\")","v":-0.20155892704132616}]
["XMD3-123",{"$f":"IF('[1]2043'!C180=\"X\",'[1]2043'!AM180,\"\")","v":-0.20903803366050894}]
["KANG201A",{"$f":"IF('[1]2043'!C340=\"X\",'[1]2043'!AM340,\"\")","v":-0.213021713210854}]
["ALW-II-46-10",{"$f":"IF('[1]2043'!C292=\"X\",'[1]2043'!AM292,\"\")","v":-0.26714435650446849}]
["ALW-II-31-1",{"$f":"IF('[1]2043'!C164=\"X\",'[1]2043'!AM164,\"\")","v":-0.3135141672190257}]
["KIN001-047",{"$f":"IF('[1]2043'!C372=\"X\",'[1]2043'!AM372,\"\")","v":-0.32256382837022679}]
["ALW-II-37-1",{"$f":"IF('[1]2043'!C200=\"X\",'[1]2043'!AM200,\"\")","v":-0.32273053455042394}]
["ALW-II-31-2",{"$f":"IF('[1]2043'!C166=\"X\",'[1]2043'!AM166,\"\")","v":-0.34580657624186922}]
["ALW-I-62-26",{"$f":"IF('[1]2043'!C162=\"X\",'[1]2043'!AM162,\"\")","v":-0.35909522685466805}]
["KANG-205d",{"$f":"IF('[1]2043'!C32=\"X\",'[1]2043'!AM32,\"\")","v":-0.36985356098079608}]
["ALW-II-46-5",{"$f":"IF('[1]2043'!C258=\"X\",'[1]2043'!AM258,\"\")","v":-0.37041013524816613}]
["CVM-04-124-3",{"$f":"IF('[1]2043'!C134=\"X\",'[1]2043'!AM134,\"\")","v":-0.3924297800302482}]
["ALW-I-62-16",{"$f":"IF('[1]2043'!C148=\"X\",'[1]2043'!AM148,\"\")","v":-0.43359188605704002}]
["KIN001-010",{"$f":"IF('[1]2043'!C324=\"X\",'[1]2043'!AM324,\"\")","v":-0.43743449619465968}]
["ALW-II-41-10",{"$f":"IF('[1]2043'!C214=\"X\",'[1]2043'!AM214,\"\")","v":-0.44521324313240673}]
["XMD3-146",{"$f":"IF('[1]2043'!C182=\"X\",'[1]2043'!AM182,\"\")","v":-0.4484106721641033}]
["KANG-205a",{"$f":"IF('[1]2043'!C28=\"X\",'[1]2043'!AM28,\"\")","v":-0.48581282459022818}]
["CVM-05-85",{"$f":"IF('[1]2043'!C132=\"X\",'[1]2043'!AM132,\"\")","v":-0.54133204253538536}]
["KIN001-024",{"$f":"IF('[1]2043'!C334=\"X\",'[1]2043'!AM334,\"\")","v":-0.54505518078204684}]
["ALW-I-40-9",{"$f":"IF('[1]2043'!C110=\"X\",'[1]2043'!AM110,\"\")","v":-0.54725554709715873}]
["ALW-I-62-24",{"$f":"IF('[1]2043'!C158=\"X\",'[1]2043'!AM158,\"\")","v":-0.55182582351119602}]
["KANG-204a",{"$f":"IF('[1]2043'!C358=\"X\",'[1]2043'!AM358,\"\")","v":-0.55932638788251154}]
["KANG-201c",{"$f":"IF('[1]2043'!C342=\"X\",'[1]2043'!AM342,\"\")","v":-0.56034871023424881}]
["ALW-II-46-27",{"$f":"IF('[1]2043'!C300=\"X\",'[1]2043'!AM300,\"\")","v":-0.60935312031968525}]
["ALW-II-38-1",{"$f":"IF('[1]2043'!C206=\"X\",'[1]2043'!AM206,\"\")","v":-0.61854084029010337}]
["ALW-I-40-11",{"$f":"IF('[1]2043'!C112=\"X\",'[1]2043'!AM112,\"\")","v":-0.63966935250520707}]
["WZ5084",{"$f":"IF('[1]2043'!C278=\"X\",'[1]2043'!AM278,\"\")","v":-0.66543599860447511}]
["ALW-II-49-2",{"$f":"IF('[1]2043'!C302=\"X\",'[1]2043'!AM302,\"\")","v":-0.67837642853778224}]
["ALW-II-46-19",{"$f":"IF('[1]2043'!C296=\"X\",'[1]2043'!AM296,\"\")","v":-0.75391086676716967}]
["KANG-203d",{"$f":"IF('[1]2043'!C356=\"X\",'[1]2043'!AM356,\"\")","v":-0.75768547047919599}]
["ALW-I-43-3",{"$f":"IF('[1]2043'!C118=\"X\",'[1]2043'!AM118,\"\")","v":-0.78014630309026756}]
["ALW-II-41-4",{"$f":"IF('[1]2043'!C212=\"X\",'[1]2043'!AM212,\"\")","v":-0.78502526393654859}]
["KIN001-013",{"$f":"IF('[1]2043'!C330=\"X\",'[1]2043'!AM330,\"\")","v":-0.81258169734102481}]
["KANG-203c",{"$f":"IF('[1]2043'!C354=\"X\",'[1]2043'!AM354,\"\")","v":-0.84838888384526145}]
["ALW-II-49-8",{"$f":"IF('[1]2043'!C304=\"X\",'[1]2043'!AM304,\"\")","v":-0.86280740337639905}]
["ALW-II-46-8",{"$f":"IF('[1]2043'!C262=\"X\",'[1]2043'!AM262,\"\")","v":-0.86688424031601885}]
["ALW-II-41-17",{"$f":"IF('[1]2043'!C248=\"X\",'[1]2043'!AM248,\"\")","v":-0.87377082749100876}]
["KANG-202c",{"$f":"IF('[1]2043'!C348=\"X\",'[1]2043'!AM348,\"\")","v":-0.87677343222129966}]
["KANG202A",{"$f":"IF('[1]2043'!C346=\"X\",'[1]2043'!AM346,\"\")","v":-0.88217366921479456}]
["ALW-I-62-22",{"$f":"IF('[1]2043'!C154=\"X\",'[1]2043'!AM154,\"\")","v":-0.89389919547181784}]
["ALW-II-46-4",{"$f":"IF('[1]2043'!C256=\"X\",'[1]2043'!AM256,\"\")","v":-0.90537679015873107}]
["CVM-04-069-2",{"$f":"IF('[1]2043'!C80=\"X\",'[1]2043'!AM80,\"\")","v":-0.91809885282471759}]
["ALW-II-57-1",{"$f":"IF('[1]2043'!C310=\"X\",'[1]2043'!AM310,\"\")","v":-0.96433057383988108}]
["KIN001-156",{"$f":"IF('[1]2043'!C19=\"X\",'[1]2043'!AM19,\"\")","v":-1.0032365357782931}]
["ALW-II-41-20",{"$f":"IF('[1]2043'!C252=\"X\",'[1]2043'!AM252,\"\")","v":-1.0041914145525004}]
["KANG-201d",{"$f":"IF('[1]2043'!C344=\"X\",'[1]2043'!AM344,\"\")","v":-1.013362650999545}]
["ALW-I-62-23",{"$f":"IF('[1]2043'!C156=\"X\",'[1]2043'!AM156,\"\")","v":-1.0930861843829409}]
["ALW-II-49-10d",{"$f":"IF('[1]2043'!C306=\"X\",'[1]2043'!AM306,\"\")","v":-1.1359287174350019}]
["WZ4141",{"$f":"IF('[1]2043'!C276=\"X\",'[1]2043'!AM276,\"\")","v":-1.1553891461851826}]
["ALW-II-37-2",{"$f":"IF('[1]2043'!C202=\"X\",'[1]2043'!AM202,\"\")","v":-1.1918965072752654}]
["KANG-203a",{"$f":"IF('[1]2043'!C352=\"X\",'[1]2043'!AM352,\"\")","v":-1.1981502241898467}]
["ALW-I-40-8",{"$f":"IF('[1]2043'!C108=\"X\",'[1]2043'!AM108,\"\")","v":-1.2070159998739793}]
["ALW-II-41-19",{"$f":"IF('[1]2043'!C250=\"X\",'[1]2043'!AM250,\"\")","v":-1.2200072153441182}]
["XMD7-27",{"$f":"IF('[1]2043'!C176=\"X\",'[1]2043'!AM176,\"\")","v":-1.253682738868279}]
["WZ3026",{"$f":"IF('[1]2043'!C228=\"X\",'[1]2043'!AM228,\"\")","v":-1.3229343216900806}]
["ALW-I-17-16",{"$f":"IF('[1]2043'!C102=\"X\",'[1]2043'!AM102,\"\")","v":-1.3268653604825984}]
["ALW-II-37-3",{"$f":"IF('[1]2043'!C204=\"X\",'[1]2043'!AM204,\"\")","v":-1.3448240403542946}]
["KIN001-052",{"$f":"IF('[1]2043'!C374=\"X\",'[1]2043'!AM374,\"\")","v":-1.4966992727735065}]
["ALW-II-46-7",{"$f":"IF('[1]2043'!C260=\"X\",'[1]2043'!AM260,\"\")","v":-1.5459343441311546}]
["XMD7-113",{"$f":"IF('[1]2043'!C178=\"X\",'[1]2043'!AM178,\"\")","v":-1.6353771043808223}]
["XMD7-2",{"$f":"IF('[1]2043'!C174=\"X\",'[1]2043'!AM174,\"\")","v":-1.7013903293080315}]
["ALW-II-41-16",{"$f":"IF('[1]2043'!C246=\"X\",'[1]2043'!AM246,\"\")","v":-2.0928667119645592}]
["YD48",{"$f":"IF('[1]2043'!C56=\"X\",'[1]2043'!AM56,\"\")","v":-2.2349563230689116}]
["XMD7-1",{"$f":"IF('[1]2043'!C172=\"X\",'[1]2043'!AM172,\"\")","v":-2.3963635805548709}]

{"sheet":"S4","index":3,"n_rows":355,"n_cols":2,"rows_kept":355,"cut":false,"hidden":false,"merged":[]}
["Table S4. Kinase selctivity profile of XMD7-1. "]
["Ambit KINOMEscan: Kinase Target","Ambit KINOMEscan: kinase activity, percentage of control (%)"]
["CLK1",0]
["CLK2",0]
["CLK4",0]
["GSK3A",0]
["HIPK1",0]
["MKNK2",0]
["PCTK1",0]
["PLK4",0.1]
["DYRK1B",0.15]
["CDK7",0.3]
["MST2",0.55000000000000004]
["FLT3(D835Y)",1.4]
["GSK3B",1.4]
["TGFBR2",1.5]
["CLK3",1.6]
["GAK",2]
["TYK2(Kin.Dom.1)",2.2000000000000002]
["MYLK",2.4]
["TAOK1",2.4]
["CSNK1G2",2.6]
["BMPR2",2.8]
["PIM2",2.8]
["MINK",2.9]
["ACVR1",3]
["FLT3(D835H)",3.1]
["AXL",3.6]
["ABL1(T315I)",4]
["RPS6KA4(Kin.Dom.2)",4.0999999999999996]
["FLT3(N841I)",4.3]
["AKT2",5.3]
["AAK1",5.4]
["MEK3",5.8]
["PIK3CG",6]
["STK16",6]
["JAK1(Kin.Dom.1)",6.1]
["FLT3(ITD)",6.3]
["DAPK1",6.7]
["MAP4K4",7]
["RPS6KA6(Kin.Dom.2)",7]
["DAPK2",7.5]
["RIOK3",7.5]
["RIOK1",7.6]
["BTK",7.9]
["KIT(V559D,T670I)",8]
["BIKE",8.4]
["CSNK1D",9]
["CAMK2A",9.4]
["SRPK3",9.4]
["ANKK1",9.5]
["PIP5K1A",9.5]
["GCN2(Kin.Dom.2,S808G)",9.6999999999999993]
["CAMK2D",10]
["CAMKK2",11]
["RPS6KA2(Kin.Dom.2)",11]
["SRPK1",11]
["CSNK1E",12]
["MAP4K2",12]
["PIM3",12]
["PIP5K2B",12]
["SgK085",12]
["CSNK1G1",13]
["MEK4",13]
["RPS6KA1(Kin.Dom.2)",13]
["TAK1",13]
["FLT3",14]
["FLT3(K663Q)",14]
["JNK1",14]
["MST4",14]
["KIT(D816V)",15]
["PIM1",15]
["TNIK",15]
["CSNK1G3",16]
["SLK",16]
["CAMK2G",17]
["ARK5",18]
["MAP4K5",18]
["CAMKK1",19]
["DAPK3",19]
["MERTK",19]
["PRKR",19]
["JNK3",20]
["RPS6KA3(Kin.Dom.1)",20]
["TSSK1",20]
["IRAK3",21]
["ERK8",22]
["KIT(V559D)",22]
["SNARK",22]
["SYK",22]
["ACVRL1",24]
["AURKC",24]
["ULK2",24]
["TAOK3",25]
["YANK3",25]
["ZAK",25]
["DRAK1",26]
["MEK1",26]
["PAK6",26]
["PRKCD",26]
["BMPR1B",27]
["CSNK2A1",27]
["IKK-alpha",27]
["RIPK4",27]
["RPS6KA4(Kin.Dom.1)",27]
["TTK",27]
["AURKB",28]
["NEK5",28]
["ACVR2B",29]
["PFTK1",30]
["ULK3",31]
["CAMK1",32]
["NEK7",32]
["ROCK2",32]
["RPS6KA5(Kin.Dom.2)",32]
["TRKA",32]
["CHEK2",33]
["MEK6",33]
["BRSK2",34]
["KIT",34]
["MAP4K3",34]
["SNF1LK2",34]
["TIE1",34]
["TLK1",34]
["ABL1",100]
["ABL1(E255K)",100]
["ABL1(F317I)",100]
["ABL1(F317L)",100]
["ABL1(H396P)",100]
["ABL1(M351T)",100]
["ABL1(Q252H)",100]
["ABL1(Y253F)",100]
["ABL2",100]
["ACVR1B",100]
["ACVR2A",100]
["ADCK3",100]
["ADCK4",100]
["AKT1",100]
["AKT3",100]
["ALK",100]
["AMPK-alpha1",100]
["AMPK-alpha2",100]
["AURKA",100]
["BLK",100]
["BMPR1A",100]
["BMX",100]
["BRAF",100]
["BRAF(V600E)",100]
["BRSK1",100]
["CAMK1D",100]
["CAMK1G",100]
["CAMK2B",100]
["CAMK4",100]
["CDC2L1",100]
["CDC2L2",100]
["CDK11",100]
["CDK2",100]
["CDK3",100]
["CDK5",100]
["CDK8",100]
["CDK9",100]
["CDKL2",100]
["CHEK1",100]
["CIT",100]
["CSF1R",100]
["CSK",100]
["CSNK1A1L",100]
["CSNK2A2",100]
["DCAMKL1",100]
["DCAMKL2",100]
["DCAMKL3",100]
["DDR1",100]
["DDR2",100]
["DLK",100]
["DMPK",100]
["DMPK2",100]
["DRAK2",100]
["EGFR",100]
["EGFR(E746-A750del)",100]
["EGFR(G719C)",100]
["EGFR(G719S)",100]
["EGFR(L747-E749del, A750P)",100]
["EGFR(L747-S752del, P753S)",100]
["EGFR(L747-T751del,Sins)",100]
["EGFR(L858R)",100]
["EGFR(L861Q)",100]
["EGFR(S752-I759del)",100]
["EPHA1",100]
["EPHA2",100]
["EPHA3",100]
["EPHA4",100]
["EPHA5",100]
["EPHA6",100]
["EPHA7",100]
["EPHA8",100]
["EPHB1",100]
["EPHB2",100]
["EPHB3",100]
["EPHB4",100]
["ERBB2",100]
["ERBB4",100]
["ERK1",100]
["ERK2",100]
["ERK3",100]
["ERK4",100]
["ERK5",100]
["FER",100]
["FES",100]
["FGFR1",100]
["FGFR2",100]
["FGFR3",100]
["FGFR3(G697C)",100]
["FGFR4",100]
["FGR",100]
["FLT1",100]
["FLT4",100]
["FRK",100]
["FYN",100]
["HCK",100]
["IGF1R",100]
["IKK-beta",100]
["IKK-epsilon",100]
["INSR",100]
["INSRR",100]
["ITK",100]
["JAK1(Kin.Dom.2)",100]
["JAK2(Kin.Dom.2)",100]
["JAK3(Kin.Dom.2)",100]
["JNK2",100]
["KIT(V559D,V654A)",100]
["LATS1",100]
["LATS2",100]
["LCK",100]
["LIMK1",100]
["LIMK2",100]
["LKB1",100]
["LOK",100]
["LTK",100]
["LYN",100]
["MAP3K3",100]
["MAP3K4",100]
["MAP3K5",100]
["MAP4K1",100]
["MAPKAPK2",100]
["MAPKAPK5",100]
["MARK1",100]
["MARK2",100]
["MARK3",100]
["MARK4",100]
["MEK2",100]
["MELK",100]
["MET",100]
["MKNK1",100]
["MLCK",100]
["MLK1",100]
["MLK2",100]
["MLK3",100]
["MRCKA",100]
["MRCKB",100]
["MST1",100]
["MST1R",100]
["MST3",100]
["MUSK",100]
["MYLK2",100]
["MYO3A",100]
["MYO3B",100]
["NDR2",100]
["NEK1",100]
["NEK2",100]
["NEK6",100]
["NEK9",100]
["NLK",100]
["p38-alpha",100]
["p38-beta",100]
["p38-delta",100]
["p38-gamma",100]
["PAK1",100]
["PAK2",100]
["PAK3",100]
["PAK4",100]
["PAK7/PAK5",100]
["PCTK2",100]
["PCTK3",100]
["PDGFRA",100]
["PDGFRB",100]
["PDPK1",100]
["PFTAIRE2",100]
["PHKG1",100]
["PHKG2",100]
["PIK3C2B",100]
["PIK3CA",100]
["PIK3CA(E545K)",100]
["PIK3CB",100]
["PIK3CD",100]
["PKAC-alpha",100]
["PKAC-beta",100]
["PKMYT1",100]
["PKN1",100]
["PKN2",100]
["PLK1",100]
["PLK3",100]
["PRKCE",100]
["PRKCH",100]
["PRKCQ",100]
["PRKD1",100]
["PRKD2",100]
["PRKD3",100]
["PRKG1",100]
["PRKG2",100]
["PRKX",100]
["PTK2",100]
["PTK2B",100]
["PTK6",100]
["RAF1",100]
["RET",100]
["RET(M918T)",100]
["RET(V804L)",100]
["RET(V804M)",100]
["RIOK2",100]
["RIPK1",100]
["RIPK2",100]
["ROS1",100]
["RPS6KA1(Kin.Dom.1)",100]
["RPS6KA2(Kin.Dom.1)",100]
["RPS6KA5(Kin.Dom.1)",100]
["RPS6KA6(Kin.Dom.1)",100]
["SgK110",100]
["SNF1LK",100]
["SRC",100]
["SRMS",100]
["SRPK2",100]
["STK33",100]
["STK35",100]
["STK36",100]
["TEC",100]
["TESK1",100]
["TGFBR1",100]
["TIE2",100]
["TLK2",100]
["TNK1",100]
["TNK2",100]
["TNNI3K",100]
["TRKB",100]
["TRKC",100]
["TXK",100]
["TYK2(Kin.Dom.2)",100]
["TYRO3",100]
["ULK1",100]
["VEGFR2",100]
["WEE1",100]
["WEE2",100]
["YANK2",100]
["YES",100]
["YSK1",100]
["ZAP70",100]

{"sheet":"S5","index":4,"n_rows":355,"n_cols":2,"rows_kept":355,"cut":false,"hidden":false,"merged":[]}
["Table S5. Kinase selectivity profile of XMD7-2."]
["Ambit KINOMEscan: Kinase Target","Ambit KINOMEscan: kinase activity, percentage of control (%)"]
["BTK",0]
["GSK3A",0]
["HIPK1",0]
["MKNK2",0]
["CLK1",0.05]
["CLK2",0.4]
["DYRK1B",0.7]
["GSK3B",0.8]
["CLK4",0.9]
["PCTK1",1.2]
["PLK4",2.6]
["TGFBR2",4.5]
["CDK7",5]
["CSNK1E",5.3]
["ACVR1",5.4]
["MEK3",6]
["FLT3(D835Y)",6.4]
["IKK-beta",6.4]
["CSNK1D",7.4]
["TYK2(Kin.Dom.1)",7.4]
["MINK",8.1]
["FLT3(D835H)",10]
["BMPR1B",11]
["CLK3",11]
["PIK3CG",11]
["ERK8",12]
["TAOK1",12]
["RPS6KA4(Kin.Dom.2)",13]
["GAK",17]
["MYLK",17]
["ABL1(T315I)",18]
["BIKE",18]
["IKK-alpha",18]
["MEK4",18]
["AXL",19]
["PIM2",21]
["RPS6KA2(Kin.Dom.2)",21]
["CSNK1G3",22]
["BMPR2",23]
["ACVRL1",24]
["MAP4K4",25]
["PIK3CD",25]
["FLT3(N841I)",27]
["MARK4",27]
["ERK2",28]
["KIT(V559D,T670I)",28]
["CSNK1G2",30]
["ARK5",31]
["DAPK1",31]
["STK16",31]
["ANKK1",32]
["DAPK2",32]
["SgK085",32]
["AAK1",100]
["ABL1",100]
["ABL1(E255K)",100]
["ABL1(F317I)",100]
["ABL1(F317L)",100]
["ABL1(H396P)",100]
["ABL1(M351T)",100]
["ABL1(Q252H)",100]
["ABL1(Y253F)",100]
["ABL2",100]
["ACVR1B",100]
["ACVR2A",100]
["ACVR2B",100]
["ADCK3",100]
["ADCK4",100]
["AKT1",100]
["AKT2",100]
["AKT3",100]
["ALK",100]
["AMPK-alpha1",100]
["AMPK-alpha2",100]
["AURKA",100]
["AURKB",100]
["AURKC",100]
["BLK",100]
["BMPR1A",100]
["BMX",100]
["BRAF",100]
["BRAF(V600E)",100]
["BRSK1",100]
["BRSK2",100]
["CAMK1",100]
["CAMK1D",100]
["CAMK1G",100]
["CAMK2A",100]
["CAMK2B",100]
["CAMK2D",100]
["CAMK2G",100]
["CAMK4",100]
["CAMKK1",100]
["CAMKK2",100]
["CDC2L1",100]
["CDC2L2",100]
["CDK11",100]
["CDK2",100]
["CDK3",100]
["CDK5",100]
["CDK8",100]
["CDK9",100]
["CDKL2",100]
["CHEK1",100]
["CHEK2",100]
["CIT",100]
["CSF1R",100]
["CSK",100]
["CSNK1A1L",100]
["CSNK1G1",100]
["CSNK2A1",100]
["CSNK2A2",100]
["DAPK3",100]
["DCAMKL1",100]
["DCAMKL2",100]
["DCAMKL3",100]
["DDR1",100]
["DDR2",100]
["DLK",100]
["DMPK",100]
["DMPK2",100]
["DRAK1",100]
["DRAK2",100]
["EGFR",100]
["EGFR(E746-A750del)",100]
["EGFR(G719C)",100]
["EGFR(G719S)",100]
["EGFR(L747-E749del, A750P)",100]
["EGFR(L747-S752del, P753S)",100]
["EGFR(L747-T751del,Sins)",100]
["EGFR(L858R)",100]
["EGFR(L861Q)",100]
["EGFR(S752-I759del)",100]
["EPHA1",100]
["EPHA2",100]
["EPHA3",100]
["EPHA4",100]
["EPHA5",100]
["EPHA6",100]
["EPHA7",100]
["EPHA8",100]
["EPHB1",100]
["EPHB2",100]
["EPHB3",100]
["EPHB4",100]
["ERBB2",100]
["ERBB4",100]
["ERK1",100]
["ERK3",100]
["ERK4",100]
["ERK5",100]
["FER",100]
["FES",100]
["FGFR1",100]
["FGFR2",100]
["FGFR3",100]
["FGFR3(G697C)",100]
["FGFR4",100]
["FGR",100]
["FLT1",100]
["FLT3",100]
["FLT3(ITD)",100]
["FLT3(K663Q)",100]
["FLT4",100]
["FRK",100]
["FYN",100]
["GCN2(Kin.Dom.2,S808G)",100]
["HCK",100]
["IGF1R",100]
["IKK-epsilon",100]
["INSR",100]
["INSRR",100]
["IRAK3",100]
["ITK",100]
["JAK1(Kin.Dom.1)",100]
["JAK1(Kin.Dom.2)",100]
["JAK2(Kin.Dom.2)",100]
["JAK3(Kin.Dom.2)",100]
["JNK1",100]
["JNK2",100]
["JNK3",100]
["KIT",100]
["KIT(D816V)",100]
["KIT(V559D)",100]
["KIT(V559D,V654A)",100]
["LATS1",100]
["LATS2",100]
["LCK",100]
["LIMK1",100]
["LIMK2",100]
["LKB1",100]
["LOK",100]
["LTK",100]
["LYN",100]
["MAP3K3",100]
["MAP3K4",100]
["MAP3K5",100]
["MAP4K1",100]
["MAP4K2",100]
["MAP4K3",100]
["MAP4K5",100]
["MAPKAPK2",100]
["MAPKAPK5",100]
["MARK1",100]
["MARK2",100]
["MARK3",100]
["MEK1",100]
["MEK2",100]
["MEK6",100]
["MELK",100]
["MERTK",100]
["MET",100]
["MKNK1",100]
["MLCK",100]
["MLK1",100]
["MLK2",100]
["MLK3",100]
["MRCKA",100]
["MRCKB",100]
["MST1",100]
["MST1R",100]
["MST2",100]
["MST3",100]
["MST4",100]
["MUSK",100]
["MYLK2",100]
["MYO3A",100]
["MYO3B",100]
["NDR2",100]
["NEK1",100]
["NEK2",100]
["NEK5",100]
["NEK6",100]
["NEK7",100]
["NEK9",100]
["NLK",100]
["p38-alpha",100]
["p38-beta",100]
["p38-delta",100]
["p38-gamma",100]
["PAK1",100]
["PAK2",100]
["PAK3",100]
["PAK4",100]
["PAK6",100]
["PAK7/PAK5",100]
["PCTK2",100]
["PCTK3",100]
["PDGFRA",100]
["PDGFRB",100]
["PDPK1",100]
["PFTAIRE2",100]
["PFTK1",100]
["PHKG1",100]
["PHKG2",100]
["PIK3C2B",100]
["PIK3CA",100]
["PIK3CA(E545K)",100]
["PIK3CB",100]
["PIM1",100]
["PIM3",100]
["PIP5K1A",100]
["PIP5K2B",100]
["PKAC-alpha",100]
["PKAC-beta",100]
["PKMYT1",100]
["PKN1",100]
["PKN2",100]
["PLK1",100]
["PLK3",100]
["PRKCD",100]
["PRKCE",100]
["PRKCH",100]
["PRKCQ",100]
["PRKD1",100]
["PRKD2",100]
["PRKD3",100]
["PRKG1",100]
["PRKG2",100]
["PRKR",100]
["PRKX",100]
["PTK2",100]
["PTK2B",100]
["PTK6",100]
["RAF1",100]
["RET",100]
["RET(M918T)",100]
["RET(V804L)",100]
["RET(V804M)",100]
["RIOK1",100]
["RIOK2",100]
["RIOK3",100]
["RIPK1",100]
["RIPK2",100]
["RIPK4",100]
["ROCK2",100]
["ROS1",100]
["RPS6KA1(Kin.Dom.1)",100]
["RPS6KA1(Kin.Dom.2)",100]
["RPS6KA2(Kin.Dom.1)",100]
["RPS6KA3(Kin.Dom.1)",100]
["RPS6KA4(Kin.Dom.1)",100]
["RPS6KA5(Kin.Dom.1)",100]
["RPS6KA5(Kin.Dom.2)",100]
["RPS6KA6(Kin.Dom.1)",100]
["RPS6KA6(Kin.Dom.2)",100]
["SgK110",100]
["SLK",100]
["SNARK",100]
["SNF1LK",100]
["SNF1LK2",100]
["SRC",100]
["SRMS",100]
["SRPK1",100]
["SRPK2",100]
["SRPK3",100]
["STK33",100]
["STK35",100]
["STK36",100]
["SYK",100]
["TAK1",100]
["TAOK3",100]
["TEC",100]
["TESK1",100]
["TGFBR1",100]
["TIE1",100]
["TIE2",100]
["TLK1",100]
["TLK2",100]
["TNIK",100]
["TNK1",100]
["TNK2",100]
["TNNI3K",100]
["TRKA",100]
["TRKB",100]
["TRKC",100]
["TSSK1",100]
["TTK",100]
["TXK",100]
["TYK2(Kin.Dom.2)",100]
["TYRO3",100]
["ULK1",100]
["ULK2",100]
["ULK3",100]
["VEGFR2",100]
["WEE1",100]
["WEE2",100]
["YANK2",100]
["YANK3",100]
["YES",100]
["YSK1",100]
["ZAK",100]
["ZAP70",100]

{"sheet":"S6","index":5,"n_rows":355,"n_cols":2,"rows_kept":355,"cut":false,"hidden":false,"merged":[]}
["Table S6. Kinase selectivity profile of XMD7-27"]
["Ambit KINOMEscan: Kinase Target","Ambit KINOMEscan: kinase activity, percentage of control (%)"]
["CLK1",0]
["GSK3A",0]
["HIPK1",0]
["MKNK2",0]
["PCTK1",0.1]
["PLK4",0.3]
["GSK3B",0.45]
["CLK2",0.5]
["CLK4",0.85]
["CDK7",1.4]
["DYRK1B",1.4]
["TAOK1",1.4]
["TYK2(Kin.Dom.1)",2.2000000000000002]
["TGFBR2",2.2999999999999998]
["FLT3(D835Y)",2.8]
["RPS6KA4(Kin.Dom.2)",3.1]
["MEK3",3.7]
["PIK3CG",4.4000000000000004]
["ACVR1",4.9000000000000004]
["AXL",4.9000000000000004]
["ABL1(T315I)",5]
["MINK",5]
["GCN2(Kin.Dom.2,S808G)",5.6]
["FLT3(D835H)",6.4]
["ANKK1",7.6]
["AAK1",7.8]
["BIKE",7.9]
["RIOK3",8.1999999999999993]
["JNK1",9.8000000000000007]
["ARK5",10]
["BMPR2",10]
["STK16",11]
["CLK3",12]
["RIOK1",12]
["FLT3(N841I)",13]
["KIT(V559D,T670I)",13]
["SNARK",13]
["SRPK3",13]
["BMPR1B",14]
["GAK",14]
["IKK-alpha",14]
["MST4",15]
["SLK",15]
["FLT3(ITD)",16]
["KIT(V559D)",16]
["RPS6KA2(Kin.Dom.2)",16]
["CAMKK2",17]
["PIM2",17]
["PIP5K1A",17]
["SYK",18]
["CAMKK1",19]
["ZAK",19]
["ACVRL1",20]
["JAK1(Kin.Dom.1)",20]
["ACVR2B",21]
["BTK",22]
["KIT",22]
["TAOK3",22]
["MEK4",23]
["MERTK",23]
["MYLK",23]
["ACVR2A",24]
["PIK3CD",24]
["TNIK",24]
["ERK8",25]
["FLT3(K663Q)",25]
["IRAK3",25]
["MAP4K4",25]
["ULK2",25]
["ULK3",25]
["CSNK1D",26]
["DMPK",26]
["AURKC",27]
["CSNK1G1",27]
["JNK3",27]
["FLT3",28]
["SRPK1",28]
["CAMK1",30]
["DCAMKL3",30]
["PIM1",30]
["RIOK2",30]
["TTK",31]
["MAP4K2",32]
["RPS6KA5(Kin.Dom.2)",32]
["TAK1",32]
["CSNK1E",33]
["DAPK1",33]
["DAPK2",33]
["FGFR4",33]
["CSNK1G2",34]
["MAP4K5",34]
["NEK5",34]
["NEK7",34]
["PIM3",34]
["PRKCD",34]
["SgK085",34]
["ABL1",100]
["ABL1(E255K)",100]
["ABL1(F317I)",100]
["ABL1(F317L)",100]
["ABL1(H396P)",100]
["ABL1(M351T)",100]
["ABL1(Q252H)",100]
["ABL1(Y253F)",100]
["ABL2",100]
["ACVR1B",100]
["ADCK3",100]
["ADCK4",100]
["AKT1",100]
["AKT2",100]
["AKT3",100]
["ALK",100]
["AMPK-alpha1",100]
["AMPK-alpha2",100]
["AURKA",100]
["AURKB",100]
["BLK",100]
["BMPR1A",100]
["BMX",100]
["BRAF",100]
["BRAF(V600E)",100]
["BRSK1",100]
["BRSK2",100]
["CAMK1D",100]
["CAMK1G",100]
["CAMK2A",100]
["CAMK2B",100]
["CAMK2D",100]
["CAMK2G",100]
["CAMK4",100]
["CDC2L1",100]
["CDC2L2",100]
["CDK11",100]
["CDK2",100]
["CDK3",100]
["CDK5",100]
["CDK8",100]
["CDK9",100]
["CDKL2",100]
["CHEK1",100]
["CHEK2",100]
["CIT",100]
["CSF1R",100]
["CSK",100]
["CSNK1A1L",100]
["CSNK1G3",100]
["CSNK2A1",100]
["CSNK2A2",100]
["DAPK3",100]
["DCAMKL1",100]
["DCAMKL2",100]
["DDR1",100]
["DDR2",100]
["DLK",100]
["DMPK2",100]
["DRAK1",100]
["DRAK2",100]
["EGFR",100]
["EGFR(E746-A750del)",100]
["EGFR(G719C)",100]
["EGFR(G719S)",100]
["EGFR(L747-E749del, A750P)",100]
["EGFR(L747-S752del, P753S)",100]
["EGFR(L747-T751del,Sins)",100]
["EGFR(L858R)",100]
["EGFR(L861Q)",100]
["EGFR(S752-I759del)",100]
["EPHA1",100]
["EPHA2",100]
["EPHA3",100]
["EPHA4",100]
["EPHA5",100]
["EPHA6",100]
["EPHA7",100]
["EPHA8",100]
["EPHB1",100]
["EPHB2",100]
["EPHB3",100]
["EPHB4",100]
["ERBB2",100]
["ERBB4",100]
["ERK1",100]
["ERK2",100]
["ERK3",100]
["ERK4",100]
["ERK5",100]
["FER",100]
["FES",100]
["FGFR1",100]
["FGFR2",100]
["FGFR3",100]
["FGFR3(G697C)",100]
["FGR",100]
["FLT1",100]
["FLT4",100]
["FRK",100]
["FYN",100]
["HCK",100]
["IGF1R",100]
["IKK-beta",100]
["IKK-epsilon",100]
["INSR",100]
["INSRR",100]
["ITK",100]
["JAK1(Kin.Dom.2)",100]
["JAK2(Kin.Dom.2)",100]
["JAK3(Kin.Dom.2)",100]
["JNK2",100]
["KIT(D816V)",100]
["KIT(V559D,V654A)",100]
["LATS1",100]
["LATS2",100]
["LCK",100]
["LIMK1",100]
["LIMK2",100]
["LKB1",100]
["LOK",100]
["LTK",100]
["LYN",100]
["MAP3K3",100]
["MAP3K4",100]
["MAP3K5",100]
["MAP4K1",100]
["MAP4K3",100]
["MAPKAPK2",100]
["MAPKAPK5",100]
["MARK1",100]
["MARK2",100]
["MARK3",100]
["MARK4",100]
["MEK1",100]
["MEK2",100]
["MEK6",100]
["MELK",100]
["MET",100]
["MKNK1",100]
["MLCK",100]
["MLK1",100]
["MLK2",100]
["MLK3",100]
["MRCKA",100]
["MRCKB",100]
["MST1",100]
["MST1R",100]
["MST2",100]
["MST3",100]
["MUSK",100]
["MYLK2",100]
["MYO3A",100]
["MYO3B",100]
["NDR2",100]
["NEK1",100]
["NEK2",100]
["NEK6",100]
["NEK9",100]
["NLK",100]
["p38-alpha",100]
["p38-beta",100]
["p38-delta",100]
["p38-gamma",100]
["PAK1",100]
["PAK2",100]
["PAK3",100]
["PAK4",100]
["PAK6",100]
["PAK7/PAK5",100]
["PCTK2",100]
["PCTK3",100]
["PDGFRA",100]
["PDGFRB",100]
["PDPK1",100]
["PFTAIRE2",100]
["PFTK1",100]
["PHKG1",100]
["PHKG2",100]
["PIK3C2B",100]
["PIK3CA",100]
["PIK3CA(E545K)",100]
["PIK3CB",100]
["PIP5K2B",100]
["PKAC-alpha",100]
["PKAC-beta",100]
["PKMYT1",100]
["PKN1",100]
["PKN2",100]
["PLK1",100]
["PLK3",100]
["PRKCE",100]
["PRKCH",100]
["PRKCQ",100]
["PRKD1",100]
["PRKD2",100]
["PRKD3",100]
["PRKG1",100]
["PRKG2",100]
["PRKR",100]
["PRKX",100]
["PTK2",100]
["PTK2B",100]
["PTK6",100]
["RAF1",100]
["RET",100]
["RET(M918T)",100]
["RET(V804L)",100]
["RET(V804M)",100]
["RIPK1",100]
["RIPK2",100]
["RIPK4",100]
["ROCK2",100]
["ROS1",100]
["RPS6KA1(Kin.Dom.1)",100]
["RPS6KA1(Kin.Dom.2)",100]
["RPS6KA2(Kin.Dom.1)",100]
["RPS6KA3(Kin.Dom.1)",100]
["RPS6KA4(Kin.Dom.1)",100]
["RPS6KA5(Kin.Dom.1)",100]
["RPS6KA6(Kin.Dom.1)",100]
["RPS6KA6(Kin.Dom.2)",100]
["SgK110",100]
["SNF1LK",100]
["SNF1LK2",100]
["SRC",100]
["SRMS",100]
["SRPK2",100]
["STK33",100]
["STK35",100]
["STK36",100]
["TEC",100]
["TESK1",100]
["TGFBR1",100]
["TIE1",100]
["TIE2",100]
["TLK1",100]
["TLK2",100]
["TNK1",100]
["TNK2",100]
["TNNI3K",100]
["TRKA",100]
["TRKB",100]
["TRKC",100]
["TSSK1",100]
["TXK",100]
["TYK2(Kin.Dom.2)",100]
["TYRO3",100]
["ULK1",100]
["VEGFR2",100]
["WEE1",100]
["WEE2",100]
["YANK2",100]
["YANK3",100]
["YES",100]
["YSK1",100]
["ZAP70",100]

{"sheet":"S7","index":6,"n_rows":84,"n_cols":4,"rows_kept":84,"cut":false,"hidden":false,"merged":[]}
["Table S7. Analysis of HCMV splice sites found in RNA sequencing (rRNA purified)."]
["24 hours post infection"]
["Gene","Spliced sequence (AD169)","DMSO","XMD7-1"]
["UL8","CCTGGCCTTG/GGAGAAGGTT",0,0]
["UL22A","CGAAGCGCAG/CGTGACGGTG",304,78]
["UL29","CACGACGAGC/CTACGCTTTT",9,6]
["UL33","CCACAACTCG/ACCCGCAACA",4,2]
["UL36","ACGTAAGCAC/CTTGCGAACA",78,48]
["UL37-1","ACACAGAAAC/CTGAAACCCG",0,0]
["UL37-2","AACCGCGGCA/TGGTGAGACT",0,1]
["UL74A","CGTTAACCAG/AGGAGGAGAC",0,0]
["UL89","CTCGGATGCT/GTTGGTGTTG",0,0]
["RNA5.0","CGGGTGGTAC/CTGGGACGCG",12,3]
["UL111-1","ACCTACGTTG/CAACGTGAGG",17,3]
["UL111-2","GCGGCAATGT/CCTCTGTTAG",1,1]
["UL112","GAGAACGACG/GCTCTCCTCC",43,36]
["UL119","TGTAGTTTTC/CTTCATTATC",8,5]
["UL122-1","AGGATGTCAC/CGAGTTCTGC",1,1]
["UL123-1","ATCTGTTTGA/CGAGTTCTGC",44,28]
["UL122/UL123-2","TGTCTCGGGC/CGTGGCACCT",43,46]
["UL122/UL123-3","AGGACGGTGA/GTCACTCTTG",37,24]
["UL128-1","GAGGTATAAC/GGATTGTAGT",20,5]
["UL128-2","ACACCGCAGC/GCGACGGTGA",6,1]
["UL131A","CACGTTGATT/CTCTTGAGCA",4,5]
["Total spliced HCMV reads",null,631,293]
["Total HCMV reads",null,121070,45116]
["Total reads",null,6620878,5448956]
["% HCMV reads",null,1.8286094382044193,0.82797512037168219]
[]
["48 hours post infection"]
["Gene","Spliced sequence (AD169)","DMSO","XMD7-1"]
["UL8","CCTGGCCTTG/GGAGAAGGTT",2,2]
["UL22A","CGAAGCGCAG/CGTGACGGTG",871,292]
["UL29","CACGACGAGC/CTACGCTTTT",6,12]
["UL33","CCACAACTCG/ACCCGCAACA",9,4]
["UL36","ACGTAAGCAC/CTTGCGAACA",54,56]
["UL37-1","ACACAGAAAC/CTGAAACCCG",0,0]
["UL37-2","AACCGCGGCA/TGGTGAGACT",0,0]
["UL74A","CGTTAACCAG/AGGAGGAGAC",3,2]
["UL89","CTCGGATGCT/GTTGGTGTTG",16,2]
["RNA5.0","CGGGTGGTAC/CTGGGACGCG",87,22]
["UL111-1","ACCTACGTTG/CAACGTGAGG",40,22]
["UL111-2","GCGGCAATGT/CCTCTGTTAG",4,6]
["UL112","GAGAACGACG/GCTCTCCTCC",96,47]
["UL119","TGTAGTTTTC/CTTCATTATC",43,18]
["UL122-1","AGGATGTCAC/CGAGTTCTGC",8,3]
["UL123-1","ATCTGTTTGA/CGAGTTCTGC",70,59]
["UL122/UL123-2","TGTCTCGGGC/CGTGGCACCT",88,85]
["UL122/UL123-3","AGGACGGTGA/GTCACTCTTG",58,51]
["UL128-1","GAGGTATAAC/GGATTGTAGT",50,19]
["UL128-2","ACACCGCAGC/GCGACGGTGA",3,5]
["UL131A","CACGTTGATT/CTCTTGAGCA",7,5]
["Total spliced HCMV reads",null,1515,712]
["Total HCMV reads",null,623017,243482]
["Total reads",null,5565926,5272304]
["% HCMV reads",null,11.193411482653561,4.6181327935566694]
[]
["72 hours post infection"]
["Gene","Spliced sequence (AD169)","DMSO ","XMD7-1"]
["UL8","CCTGGCCTTG/GGAGAAGGTT",7,4]
["UL22A","CGAAGCGCAG/CGTGACGGTG",5826,1556]
["UL29","CACGACGAGC/CTACGCTTTT",21,6]
["UL33","CCACAACTCG/ACCCGCAACA",51,17]
["UL36","ACGTAAGCAC/CTTGCGAACA",131,54]
["UL37-1","ACACAGAAAC/CTGAAACCCG",10,1]
["UL37-2","AACCGCGGCA/TGGTGAGACT",1,0]
["UL74A","CGTTAACCAG/AGGAGGAGAC",19,9]
["UL89","CTCGGATGCT/GTTGGTGTTG",48,22]
["RNA5.0","CGGGTGGTAC/CTGGGACGCG",234,107]
["UL111-1","ACCTACGTTG/CAACGTGAGG",159,69]
["UL111-2","GCGGCAATGT/CCTCTGTTAG",23,17]
["UL112","GAGAACGACG/GCTCTCCTCC",198,101]
["UL119","TGTAGTTTTC/CTTCATTATC",64,44]
["UL122-1","AGGATGTCAC/CGAGTTCTGC",30,12]
["UL123-1","ATCTGTTTGA/CGAGTTCTGC",177,63]
["UL122/UL123-2","TGTCTCGGGC/CGTGGCACCT",174,100]
["UL122/UL123-3","AGGACGGTGA/GTCACTCTTG",142,56]
["UL128-1","GAGGTATAAC/GGATTGTAGT",136,96]
["UL128-2","ACACCGCAGC/GCGACGGTGA",19,6]
["UL131A","CACGTTGATT/CTCTTGAGCA",19,8]
["Total spliced HCMV reads",null,7489,2348]
["Total HCMV reads",null,1563741,802696]
["Total reads",null,6003026,5385134]
["% HCMV reads",null,26.049212513822194,14.905775789423252]