Screening for Novel Small-Molecule Inhibitors Targeting the Assembly of Influenza Virus Polymerase Complex by a Bimolecular Luminescence Complementation-Based Reporter System

Supplemental material

• Supplemental file 1 -

  Fig. S1 (Carton of BiLC vectors.)

  Fig. S2 (Structure model of PA-PB1 interaction detected by BiLC.)

  Fig. S3 (Location of the selected mutation residues on PAc-PB1n complex or PB1c-PB2n complex.)

  Fig. S4 (Flow chart and BiLC assay of PB1c-PB2n interaction.)

  Fig. S5 (Inhibitory function of small molecules to PB1c-PB2n interaction detected by BiLC assay.)

  Fig. S6 (Inhibitory function of small molecules to IAV-Luc virus replication.)

  Fig. S7 (Cytotoxicity of molecule 5.)

  Fig. S8 (Interaction between PA and PB2 detected by BiLC assay.)

  Fig. S9 (Assembly of influenza virus polymerase.)

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