Supplementary table 1: transcription factor binding sites enriched in the gene-module regulated by f33 rule	
Transcription factor binding sites	q values
FOXC1-MA0032.1	0.043301374
NHLH1-MA0048.1	0.000145074
MZF1_1-4-MA0056.1	0.030536729
MZF1_5-13-MA0057.1	0.000145074
Pax2-MA0067.1	0.04813707
SPIB-MA0081.1	0.044062607
REL-MA0101.1	0.001094218
RELA-MA0107.1	0.009713864
Zfp423-MA0116.1	0.00206111
Mafb-MA0117.1	0.0305242
ZNF354C-MA0130.1	0.043301374
BRCA1-MA0133.1	0.043301374
Klf4-MA0039.2	0.00206111
INSM1-MA0155.1	0.035392564
NFIC-MA0161.1	0.043301374
Esrrb-MA0141.2	0.004358232
Atoh1-MA0461.1	0.000145074
E2F6-MA0471.1	0.043301374
EGR2-MA0472.1	0.014583755
FOSL1-MA0477.1	0.014974196
FOSL2-MA0478.1	0.000123117
JUN (var.2)-MA0489.1	0.026584723
JUNB-MA0490.1	0.00206111
Klf1-MA0493.1	0.043301374
Myod1-MA0499.1	0.000391738
Myog-MA0500.1	0.001478258
Rxra-MA0512.1	0.007604607
Tcf12-MA0521.1	0.00044114
Tcf3-MA0522.1	0.00020938
TFAP2C-MA0524.1	0.000145074
EBF1-MA0154.2	2.62E-08
EGR1-MA0162.2	0.011402703
MAX-MA0058.2	0.018779951
Myc-MA0147.2	0.011402703
Spi1-MA0080.3	0.008592742
SP1-MA0079.3	0.002726419
SRF-MA0083.2	0.043301374
ZEB1-MA0103.2	0.011870493
ESRRA-MA0592.1	0.007656511
SREBF2-MA0596.1	0.011142153
THAP1-MA0597.1	0.028201132
EHF-MA0598.1	0.043301374
KLF5-MA0599.1	0.009914981
TFAP2A-MA0003.1	0.043301374
GATA2-MA0036.1	0.043301374
GATA3-MA0037.1	0.043301374
NF-kappaB-MA0061.1	0.001152226
YY1-MA0095.1	0.043301374
ETS1-MA0098.1	0.043301374
Esrrb-MA0141.1	0.002628776
Stat3-MA0144.1	0.043057139
EBF1-MA0154.1	0.000145074
SP1-MA0079.2	0.000145074
SOX10-MA0442.1	0.043301374