This PDF file includes:

• fig. S1. TET2 structure, schematics of the NMR in situ kinetics experiment and disassembly, and re-assembly of TET2.
  
• fig. S2. Subtraction of the dodecamer evolution from the kinetic spectral series for deconvolution of the flexible monomeric intermediate evolution from the dodecamer buildup.
  
• fig. S3. Fit of dodecamer and dodecamer-like species buildup curve.
  
• fig. S4. EM images of TET2 self-assembly including the zooms of the red-squared regions.
  
• fig. S5. EM images of TET2 decamer intermediate.
  
• fig. S6. Analysis of TET2 oligomeric interfaces using PISA (45).
  
• Reference (45)

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