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Fig. 5. (A) Representative positron-emission tomography (PET) images showing the fluoro-m-tyrosine (FMT) signal at two different anterior-posterior levels in the brain of a monkey before and 3 months after MPTP treatment. Note the marked reduction in signal in the basal ganglia on the side of the brain infused with MPTP (right side). (B) K_I values obtained from PET scans in the right and left basal ganglia of MPTP-treated monkeys that had been maintained on either caloric restriction (CR; n = 7) or control (n = 6) diets. Values are the mean and SEM. There was no significant diet effect on the mean K_I values of the left or right basal ganglia. Estimates [microliters per minute (mean ± SEM)] for respective left and right sides for controls were 54.3 ± 7.9 and 55.3 ± 10.4 and for CR monkeys were 53.1 ± 16.0 and 55.4 ± 15.8.