mutation likelihood blosum62 nt_mutation pclass res sres isen neu RES SCORE (RS) Normalized RS CONSERVATION TCGA L107P 0.001079 -3 [C[T>C]C] Strong resistance 0.235 0.539 0.154 0.072 0.332 1.0 0.12 NO D167A 4.71e-05 -2 [G[A>C]C] Strong resistance 0.299 0.473 0.183 0.045 0.319 0.965000528031 3.21 NO H147Y 0.0003773 2 [G[C>T]A] Strong resistance 0.245 0.51 0.15 0.095 0.312 0.946232626114 2.65 NO M108L 0.001356 2 [C[A>C]T] Strong resistance 0.295 0.454 0.192 0.059 0.294 0.899632923446 1.53 NO M108L 0.0002346 2 [C[A>T]T] Strong resistance 0.295 0.454 0.192 0.059 0.294 0.899632923446 1.53 NO I86M 0.0002278 1 [T[C>G]A] Resistance 0.496 0.256 0.145 0.103 0.279 0.860637445824 0.95 NO L150P 0.001079 -3 [C[T>C]C] Strong resistance 0.262 0.465 0.17 0.104 0.277 0.854493423099 3.05 NO E33K 0.0011407 1 [C[G>A]A] Resistance 0.433 0.31 0.19 0.067 0.271 0.839413888298 0.41 NO G34V 0.0001393 -3 [G[G>T]C] Strong resistance 0.235 0.487 0.219 0.059 0.269 0.83431152834 0.95 NO F168I 0.0019397 0 [C[T>A]T] Resistance 0.436 0.301 0.185 0.079 0.264 0.821779559342 2.76 NO E33D 2.76e-05 2 [A[G>T]G] Resistance 0.416 0.316 0.201 0.067 0.26 0.810523494331 0.41 NO E33D 1.91e-05 2 [A[G>C]G] Resistance 0.416 0.316 0.201 0.067 0.26 0.810523494331 0.41 NO G34S 0.0013731 0 [G[G>A]G] Resistance 0.492 0.248 0.2 0.06 0.259 0.807838414484 0.95 NO I84M 0.0010302 1 [T[T>G]G] Resistance 0.443 0.287 0.173 0.097 0.258 0.805069974029 2.28 NO D149A 4.71e-05 -2 [G[A>C]C] Resistance 0.368 0.351 0.162 0.119 0.257 0.803490923716 3.19 NO L107V 0.00036 1 [C[C>G]T] Strong resistance 0.319 0.398 0.216 0.067 0.254 0.794798088709 0.12 NO M108K 0.0009666 -1 [A[T>A]G] Strong resistance 0.315 0.401 0.21 0.074 0.254 0.794093205309 1.53 NO L157P 0.001079 -3 [C[T>C]C] Strong resistance 0.195 0.507 0.214 0.084 0.254 0.794056976454 0.12 NO I165M 0.0007641 1 [T[C>G]T] Resistance 0.389 0.329 0.191 0.09 0.25 0.785346944845 -0.15 NO D111A 0.0003286 -2 [G[A>C]T] Strong resistance 0.281 0.422 0.177 0.12 0.248 0.78068542478 0.68 NO I31M 0.0003015 1 [T[C>G]G] Resistance 0.435 0.288 0.219 0.058 0.246 0.77352615109 1.53 NO G85V 0.0001909 -3 [G[G>T]A] Strong resistance 0.327 0.374 0.205 0.093 0.237 0.751005802765 -0.39 NO G37S 0.0014177 0 [C[G>A]G] Resistance 0.45 0.26 0.192 0.097 0.234 0.743121044447 0.63 NO G37V 0.0001393 -3 [G[G>T]C] Strong resistance 0.24 0.444 0.201 0.115 0.23 0.732299043634 0.63 NO H147Q 8.17e-05 0 [A[C>G]C] Resistance 0.386 0.312 0.191 0.111 0.229 0.728486753408 2.65 NO H147Q 0.0006416 0 [A[C>A]C] Resistance 0.386 0.312 0.191 0.111 0.229 0.728486753408 2.65 NO Y36C 0.0001817 -2 [T[A>G]C] Strong resistance 0.305 0.384 0.211 0.1 0.227 0.724413260343 0.52 NO I86V 0.000269 3 [A[A>G]T] Resistance 0.362 0.33 0.204 0.104 0.223 0.715058855186 0.95 NO E33V 7.62e-05 -2 [G[A>T]G] Strong resistance 0.333 0.358 0.225 0.084 0.223 0.714338762183 0.41 NO I84T 0.001311 -1 [A[T>C]T] Strong resistance 0.302 0.381 0.2 0.117 0.222 0.711145841799 2.28 NO L155P 0.0012621 -3 [C[T>C]G] Strong resistance 0.229 0.449 0.228 0.094 0.221 0.709263543537 -0.15 NO P152S 0.0202731 -1 [G[C>T]C] Strong resistance 0.214 0.455 0.183 0.148 0.22 0.705095641673 1.4 NO D167N 0.0009667 1 [T[G>A]A] Strong resistance 0.286 0.397 0.232 0.085 0.219 0.703660598573 3.21 NO P58S 0.0956955 -1 [C[C>T]C] Strong resistance 0.285 0.396 0.216 0.103 0.219 0.703017584685 -0.6 NO E33A 9.07e-05 -1 [G[A>C]G] Strong resistance 0.324 0.355 0.17 0.151 0.219 0.702862814234 0.41 NO M108R 0.0009162 -1 [A[T>G]G] Strong resistance 0.331 0.354 0.239 0.075 0.216 0.694247496295 1.53 NO H147D 4.34e-05 -1 [G[C>G]A] Strong resistance 0.317 0.362 0.202 0.12 0.215 0.691591361628 2.65 NO G85A 4.34e-05 0 [G[G>C]A] Resistance 0.436 0.257 0.221 0.086 0.213 0.688647203244 -0.39 NO I86T 0.0003081 -1 [A[T>C]C] Resistance 0.375 0.309 0.204 0.113 0.213 0.688250930567 0.95 NO I31V 0.0006799 3 [C[A>G]T] Strong resistance 0.297 0.383 0.245 0.076 0.213 0.686699386922 1.53 NO F168C 0.0017249 -2 [T[T>G]T] Resistance 0.351 0.33 0.213 0.105 0.212 0.685761448117 2.76 NO P58H 0.0007115 -2 [C[C>A]C] Resistance 0.343 0.335 0.201 0.121 0.211 0.683222478089 -0.6 NO D106A 4.71e-05 -2 [G[A>C]C] Resistance 0.347 0.329 0.206 0.118 0.209 0.676337485468 2.01 NO I31T 0.0003081 -1 [A[T>C]C] Strong resistance 0.311 0.366 0.245 0.078 0.208 0.675570139486 1.53 NO I86F 0.0001647 0 [A[A>T]T] Resistance 0.375 0.303 0.2 0.121 0.208 0.673955286527 0.95 NO P58T 0.0007115 -1 [C[C>A]C] Resistance 0.341 0.333 0.203 0.123 0.208 0.673598759975 -0.6 NO D167G 0.0001711 -1 [G[A>G]C] Strong resistance 0.294 0.38 0.253 0.073 0.206 0.669777895105 3.21 NO L150F 0.07498 0 [C[C>T]T] Strong resistance 0.302 0.367 0.203 0.128 0.206 0.669726573049 3.05 NO I86N 0.0008346 -3 [A[T>A]C] Resistance 0.363 0.311 0.205 0.121 0.205 0.666149869241 0.95 NO I103M 0.0001839 1 [T[A>G]G] Resistance 0.4 0.28 0.223 0.097 0.204 0.663484606732 1.72 NO I83M 0.0002278 1 [T[C>G]A] Strong resistance 0.285 0.382 0.224 0.109 0.203 0.662320229979 1.56 NO Y36H 0.0011072 2 [C[T>C]A] Strong resistance 0.297 0.371 0.226 0.105 0.203 0.66184293476 0.52 NO I84N 0.0034801 -3 [A[T>A]T] Strong resistance 0.313 0.354 0.21 0.123 0.202 0.657764483221 2.28 NO L156P 0.0012621 -3 [C[T>C]G] Strong resistance 0.243 0.419 0.243 0.095 0.201 0.654736859948 1.99 NO T190P 0.0001374 -1 [C[A>C]C] Strong resistance 0.322 0.345 0.221 0.112 0.2 0.652587072607 0.17 NO M38L 0.001356 2 [C[A>C]T] Strong resistance 0.21 0.449 0.266 0.075 0.199 0.651058399948 -0.23 NO M38L 0.0002346 2 [C[A>T]T] Strong resistance 0.21 0.449 0.266 0.075 0.199 0.651058399948 -0.23 NO K114R 0.0003019 2 [A[A>G]G] Resistance 0.605 0.089 0.188 0.118 0.199 0.649895988657 -0.42 NO I86L 0.0002008 2 [A[A>C]T] Resistance 0.362 0.306 0.215 0.117 0.198 0.647072652604 0.95 NO L150H 0.0014538 -3 [C[T>A]C] Strong resistance 0.295 0.365 0.21 0.13 0.197 0.646722672904 3.05 NO Q105P 0.0001451 -1 [C[A>C]G] Strong resistance 0.321 0.344 0.231 0.104 0.196 0.643753677962 -0.5 NO I84L 0.001356 2 [C[A>C]T] Strong resistance 0.329 0.335 0.223 0.113 0.195 0.641135887163 2.28 NO H147R 0.0003212 0 [C[A>G]C] Strong resistance 0.331 0.332 0.214 0.123 0.195 0.640657815497 2.65 NO Y30C 0.0001817 -2 [T[A>G]C] Strong resistance 0.328 0.336 0.232 0.104 0.195 0.639140769497 -0.66 NO S153A 0.0010349 1 [T[T>G]C] Resistance 0.39 0.276 0.191 0.143 0.195 0.638954931942 0.41 NO F168S 0.0024801 -2 [T[T>C]T] Resistance 0.388 0.278 0.203 0.13 0.194 0.636488756561 2.76 NO G34R 6.2e-06 -2 [G[G>C]G] Resistance 0.381 0.29 0.254 0.074 0.193 0.636205872312 0.95 NO G32V 0.0001393 -3 [G[G>T]C] Strong resistance 0.27 0.392 0.278 0.06 0.193 0.634957353771 1.48 NO L107H 0.0014538 -3 [C[T>A]C] Resistance 0.344 0.321 0.237 0.099 0.193 0.634218360139 0.12 NO H147P 0.0001374 -2 [C[A>C]C] Strong resistance 0.329 0.33 0.222 0.119 0.191 0.628459681776 2.65 NO G37A 6.04e-05 0 [G[G>C]C] Resistance 0.332 0.329 0.229 0.111 0.191 0.628448414331 0.63 NO I53M 0.0002278 1 [T[C>G]A] Resistance 0.416 0.256 0.252 0.075 0.19 0.626769454537 1.35 NO M108V 0.0006799 1 [C[A>G]T] Strong resistance 0.282 0.378 0.28 0.06 0.189 0.625051234878 1.53 NO T68P 6.16e-05 -1 [A[A>C]C] Strong resistance 0.213 0.432 0.233 0.122 0.189 0.623470232006 -0.1 NO F168Y 0.0048708 3 [T[T>A]T] Resistance 0.338 0.325 0.26 0.076 0.189 0.623428917574 2.76 NO S57R 0.0004393 -1 [G[C>G]C] Resistance 0.424 0.244 0.225 0.107 0.188 0.622254731391 -0.58 NO S57R 0.0002341 -1 [G[C>A]C] Resistance 0.424 0.244 0.225 0.107 0.188 0.622254731391 -0.58 NO S57R 0.0001451 -1 [C[A>C]G] Resistance 0.424 0.244 0.225 0.107 0.188 0.622254731391 -0.58 NO I84F 0.0002346 0 [C[A>T]T] Resistance 0.349 0.31 0.223 0.119 0.187 0.620413394955 2.28 NO K117R 0.0003019 2 [A[A>G]G] Resistance 0.574 0.098 0.138 0.19 0.186 0.616130049487 -0.52 NO I31N 0.0008346 -3 [A[T>A]C] Strong resistance 0.313 0.345 0.265 0.077 0.186 0.616120955778 1.53 NO E71D 0.0001073 2 [A[G>C]A] Resistance 0.364 0.297 0.243 0.096 0.186 0.615793852954 1.77 NO E71D 0.0002104 2 [A[G>T]A] Resistance 0.364 0.297 0.243 0.096 0.186 0.615793852954 1.77 NO P58R 0.0004366 -2 [C[C>G]C] Resistance 0.334 0.321 0.224 0.121 0.185 0.614794645768 -0.6 NO L107F 0.07498 0 [C[C>T]T] Resistance 0.357 0.302 0.246 0.095 0.184 0.61095197797 0.12 NO P152L 0.07498 -3 [C[C>T]T] Strong resistance 0.209 0.43 0.22 0.142 0.183 0.609285907253 1.4 NO D111N 0.0009756 1 [A[G>A]A] Strong resistance 0.28 0.369 0.244 0.107 0.182 0.606843168005 0.68 NO D167E 0.000217 2 [A[C>G]T] Resistance 0.378 0.277 0.207 0.139 0.182 0.605564390203 3.21 NO D167E 0.0005138 2 [A[C>A]T] Resistance 0.378 0.277 0.207 0.139 0.182 0.605564390203 3.21 NO P58L 0.0956955 -3 [C[C>T]C] Strong resistance 0.258 0.39 0.262 0.09 0.181 0.604555142073 -0.6 NO L107I 0.0013983 2 [C[C>A]T] Resistance 0.366 0.294 0.264 0.076 0.181 0.603576787678 0.12 NO Y36F 7.09e-05 3 [T[A>T]C] Resistance 0.384 0.27 0.203 0.143 0.181 0.603285298212 0.52 NO C166R 0.0012621 -3 [C[T>C]G] Strong resistance 0.296 0.355 0.263 0.087 0.179 0.599533792605 1.61 NO I31F 0.0002346 0 [C[A>T]T] Strong resistance 0.323 0.331 0.271 0.075 0.179 0.59950425291 1.53 NO G85R 1.73e-05 -2 [T[G>C]G] Resistance 0.464 0.202 0.239 0.095 0.179 0.597673341273 -0.39 NO G85R 0.0010782 -2 [T[G>A]G] Resistance 0.464 0.202 0.239 0.095 0.179 0.597673341273 -0.39 NO Y36D 1.49e-05 -3 [C[T>G]A] Resistance 0.326 0.323 0.24 0.111 0.178 0.594651024791 0.52 NO E71K 0.0009652 1 [G[G>A]A] Resistance 0.341 0.308 0.233 0.118 0.177 0.592960987288 1.77 NO L150I 0.0013983 2 [C[C>A]T] Resistance 0.345 0.306 0.243 0.106 0.177 0.592429238866 3.05 NO I103R 3.59e-05 -3 [A[T>G]A] Strong resistance 0.235 0.405 0.26 0.1 0.177 0.592004710047 1.72 NO T110P 6.16e-05 -1 [A[A>C]C] Strong resistance 0.252 0.39 0.264 0.093 0.177 0.591689711818 -0.39 NO K55R 0.0003665 2 [A[A>G]A] Resistance 0.349 0.304 0.259 0.088 0.176 0.591288561952 -0.23 NO Y30H 0.0004183 2 [G[T>C]A] Resistance 0.325 0.323 0.252 0.1 0.175 0.587362714836 -0.66 NO I165T 0.0003081 -1 [A[T>C]C] Strong resistance 0.268 0.373 0.257 0.102 0.174 0.585662146407 -0.15 NO I165F 7.08e-05 0 [G[A>T]T] Strong resistance 0.262 0.379 0.261 0.098 0.174 0.585503535248 -0.15 NO G34C 2.81e-05 -3 [G[G>T]G] Resistance 0.333 0.316 0.267 0.083 0.174 0.584358256654 0.95 NO Y36N 4.94e-05 -2 [C[T>A]A] Strong resistance 0.295 0.346 0.232 0.127 0.174 0.583862527318 0.52 NO D167Y 0.000237 -3 [T[G>T]A] Strong resistance 0.293 0.353 0.282 0.072 0.173 0.582592897905 3.21 NO G37R 3.78e-05 -2 [C[G>C]G] Resistance 0.374 0.275 0.227 0.124 0.173 0.582579808316 0.63 NO D149G 0.0001711 -1 [G[A>G]C] Resistance 0.344 0.298 0.207 0.151 0.172 0.580976926327 3.19 NO V39M 0.0014704 1 [G[G>A]T] Resistance 0.338 0.312 0.279 0.072 0.172 0.579708354026 1.75 NO C166W 0.001701 -2 [G[T>G]G] Strong resistance 0.284 0.358 0.271 0.087 0.172 0.579070215171 1.61 NO Q105L 0.0001087 -2 [C[A>T]G] Strong resistance 0.225 0.411 0.276 0.088 0.172 0.578990428113 -0.5 NO I56M 0.0002278 1 [T[C>G]A] Resistance 0.416 0.239 0.256 0.088 0.171 0.578239719591 0.6 NO G34A 6.04e-05 0 [G[G>C]C] Resistance 0.378 0.277 0.292 0.053 0.17 0.575592904104 0.95 NO P152T 0.0002341 -1 [G[C>A]C] Strong resistance 0.276 0.354 0.195 0.174 0.17 0.573666767519 1.4 NO K151M 0.000114 -1 [A[A>T]G] Resistance 0.356 0.289 0.242 0.113 0.169 0.572942023744 2.28 NO D111G 0.0002356 -1 [G[A>G]T] Strong resistance 0.277 0.359 0.248 0.115 0.169 0.572743811334 0.68 NO I165N 0.0008346 -3 [A[T>A]C] Strong resistance 0.265 0.371 0.26 0.105 0.168 0.569343622428 -0.15 NO K151N 0.0001679 0 [A[G>T]C] Resistance 0.409 0.242 0.256 0.093 0.168 0.568523356065 2.28 NO K151N 8.17e-05 0 [A[G>C]C] Resistance 0.409 0.242 0.256 0.093 0.168 0.568523356065 2.28 NO P152H 0.0013983 -2 [C[C>A]T] Strong resistance 0.278 0.35 0.193 0.179 0.167 0.567894185986 1.4 NO I31L 0.001356 2 [C[A>C]T] Strong resistance 0.293 0.348 0.284 0.075 0.167 0.567889610958 1.53 NO T68N 0.0006416 0 [A[C>A]C] Strong resistance 0.231 0.398 0.243 0.129 0.167 0.567520051826 -0.1 NO T63N 0.0006416 0 [A[C>A]C] Resistance 0.431 0.216 0.213 0.14 0.167 0.566053714032 -0.47 NO E109K 0.0009652 1 [G[G>A]A] Resistance 0.399 0.25 0.262 0.09 0.166 0.56323125624 -0.39 NO I84V 0.0006799 3 [C[A>G]T] Strong resistance 0.27 0.362 0.245 0.124 0.166 0.563060964251 2.28 NO C166F 0.0002911 -2 [T[G>T]T] Strong resistance 0.308 0.332 0.28 0.08 0.166 0.562870357391 1.61 NO E109D 3.59e-05 2 [A[A>C]A] Resistance 0.411 0.239 0.27 0.08 0.165 0.560518183499 -0.39 NO E109D 9.84e-05 2 [A[A>T]A] Resistance 0.411 0.239 0.27 0.08 0.165 0.560518183499 -0.39 NO K151T 6.37e-05 -1 [A[A>C]G] Resistance 0.33 0.307 0.245 0.118 0.164 0.560035863204 2.28 NO G34D 0.0025766 -1 [G[G>A]C] Strong resistance 0.318 0.321 0.275 0.085 0.164 0.557856160751 0.95 NO H147N 0.000475 1 [G[C>A]A] Resistance 0.339 0.3 0.258 0.103 0.163 0.555535848866 2.65 NO M108I 1.73e-05 1 [T[G>C]G] Strong resistance 0.272 0.366 0.311 0.052 0.163 0.555013168238 1.53 NO M108I 0.0010782 1 [T[G>A]G] Strong resistance 0.272 0.366 0.311 0.052 0.163 0.555013168238 1.53 NO M108I 5.77e-05 1 [T[G>T]G] Strong resistance 0.272 0.366 0.311 0.052 0.163 0.555013168238 1.53 NO Q105R 0.0003148 1 [C[A>G]G] Strong resistance 0.253 0.377 0.267 0.103 0.162 0.553922248648 -0.5 NO R67K 0.0009756 2 [A[G>A]A] Strong resistance 0.312 0.32 0.248 0.12 0.16 0.548471191733 0.06 NO C166Y 0.00245 -2 [T[G>A]T] Strong resistance 0.3 0.335 0.281 0.085 0.16 0.548407236982 1.61 NO S41A 0.0008952 1 [C[T>G]C] Resistance 0.433 0.21 0.238 0.119 0.159 0.545788392374 -0.52 NO A52S 0.0001679 1 [A[G>T]C] Strong resistance 0.16 0.458 0.304 0.078 0.157 0.539311780504 1.85 NO E33G 0.0001519 -2 [G[A>G]G] Resistance 0.321 0.306 0.234 0.138 0.156 0.538476880916 0.41 NO G37C 4.87e-05 -3 [C[G>T]G] Strong resistance 0.293 0.333 0.258 0.116 0.155 0.535191834687 0.63 NO L112P 0.0049426 -3 [C[T>C]T] Strong resistance 0.229 0.39 0.267 0.115 0.153 0.531196426996 -0.31 NO L157H 0.0014538 -3 [C[T>A]C] Strong resistance 0.248 0.374 0.278 0.101 0.153 0.530621948167 0.12 NO I83N 0.0008346 -3 [A[T>A]C] Strong resistance 0.173 0.438 0.264 0.124 0.153 0.52992206172 1.56 NO S29P 0.001079 -1 [C[T>C]C] Resistance 0.413 0.223 0.241 0.123 0.153 0.529697860914 -0.66 NO G37D 0.0025766 -1 [G[G>A]C] Strong resistance 0.299 0.324 0.241 0.137 0.153 0.529276776115 0.63 NO T63P 4.71e-05 -1 [G[A>C]C] Resistance 0.395 0.235 0.219 0.151 0.152 0.527410764847 -0.47 NO Q17L 0.0001087 -2 [C[A>T]G] Strong resistance 0.261 0.359 0.27 0.11 0.151 0.525304444245 -0.66 NO I165L 0.0003286 2 [G[A>C]T] Strong resistance 0.228 0.39 0.277 0.106 0.151 0.524939872276 -0.15 NO L115P 0.001079 -3 [C[T>C]C] Strong resistance 0.281 0.339 0.247 0.133 0.151 0.524633387792 -0.44 NO V39A 0.0004789 0 [G[T>C]G] Strong resistance 0.252 0.368 0.277 0.103 0.15 0.522889251367 1.75 NO K151R 0.0003019 2 [A[A>G]G] Resistance 0.429 0.207 0.252 0.112 0.15 0.522871593034 2.28 NO E33Q 6.44e-05 2 [C[G>C]A] Resistance 0.374 0.26 0.287 0.079 0.15 0.522600390876 0.41 NO Y30D 1.03e-05 -3 [G[T>G]A] Resistance 0.355 0.274 0.261 0.111 0.15 0.522258888608 -0.66 NO T190R 0.0001073 -1 [A[C>G]A] Resistance 0.325 0.297 0.241 0.137 0.149 0.51919398017 0.17 NO K151Q 1.49e-05 1 [C[A>C]A] Resistance 0.37 0.251 0.191 0.189 0.149 0.51918007819 2.28 NO L157F 0.0155456 0 [G[C>T]T] Strong resistance 0.253 0.364 0.276 0.106 0.148 0.517521657181 0.12 NO Y30N 5.15e-05 -2 [G[T>A]A] Resistance 0.354 0.273 0.259 0.114 0.148 0.517191332641 -0.66 NO G32S 0.0014177 0 [C[G>A]G] Resistance 0.466 0.178 0.3 0.056 0.148 0.515887667923 1.48 NO I83T 0.0003081 -1 [A[T>C]C] Strong resistance 0.173 0.435 0.273 0.119 0.148 0.515708648876 1.56 NO D149N 0.0009667 1 [T[G>A]A] Resistance 0.377 0.245 0.212 0.166 0.147 0.514706829078 3.19 NO K55N 9.84e-05 0 [A[A>T]A] Resistance 0.346 0.281 0.278 0.095 0.146 0.512784806878 -0.23 NO K55N 3.59e-05 0 [A[A>C]A] Resistance 0.346 0.281 0.278 0.095 0.146 0.512784806878 -0.23 NO V51G 1.03e-05 -3 [G[T>G]A] Strong resistance 0.279 0.336 0.254 0.131 0.145 0.508141204538 0.01 NO V39G 0.001701 -3 [G[T>G]G] Strong resistance 0.259 0.357 0.289 0.095 0.145 0.507938470753 1.75 NO M38K 0.0009666 -1 [A[T>A]G] Strong resistance 0.28 0.338 0.292 0.091 0.143 0.504954653059 -0.23 NO D149Y 0.000237 -3 [T[G>T]A] Resistance 0.369 0.254 0.256 0.122 0.142 0.502149355496 3.19 NO N154D 0.0001599 1 [C[A>G]A] Strong resistance 0.254 0.357 0.27 0.119 0.142 0.500604906637 1.88 NO K54R 0.0003019 2 [A[A>G]G] Strong resistance 0.284 0.329 0.272 0.115 0.14 0.496292553923 1.88 NO F19I 0.001018 0 [G[T>A]T] Resistance 0.351 0.272 0.292 0.085 0.14 0.49614121401 -0.63 NO L150V 0.00036 1 [C[C>G]T] Strong resistance 0.29 0.325 0.283 0.102 0.14 0.494835251134 3.05 NO P152R 0.00036 -2 [C[C>G]T] Strong resistance 0.259 0.343 0.232 0.167 0.137 0.487498390813 1.4 NO V51A 0.0004183 0 [G[T>C]A] Strong resistance 0.271 0.334 0.248 0.147 0.136 0.486532514044 0.01 NO L75F 8.76e-05 0 [T[A>C]C] Resistance 0.334 0.278 0.253 0.135 0.135 0.483160610025 0.81 NO L75F 7.09e-05 0 [T[A>T]C] Resistance 0.334 0.278 0.253 0.135 0.135 0.483160610025 0.81 NO S153C 0.0010406 -1 [T[C>G]C] Strong resistance 0.286 0.316 0.235 0.162 0.134 0.479964799703 0.41 NO D167V 4.71e-05 -3 [G[A>T]C] Strong resistance 0.265 0.347 0.334 0.054 0.134 0.479326024219 3.21 NO C166S 0.000101 -1 [T[G>C]T] Strong resistance 0.249 0.36 0.319 0.073 0.134 0.478984403928 1.61 NO C166S 0.0007718 -1 [C[T>A]G] Strong resistance 0.249 0.36 0.319 0.073 0.134 0.478984403928 1.61 NO S153P 0.0019071 -1 [T[T>C]C] Strong resistance 0.281 0.322 0.246 0.151 0.133 0.478356860346 0.41 NO E71A 9.07e-05 -1 [G[A>C]G] Strong resistance 0.259 0.344 0.269 0.128 0.133 0.4777639843 1.77 NO S29A 0.0008952 1 [C[T>G]C] Resistance 0.465 0.159 0.261 0.114 0.133 0.476187988441 -0.66 NO F168V 0.0025875 -1 [C[T>G]T] Resistance 0.308 0.303 0.292 0.097 0.132 0.475565396797 2.76 NO C166G 0.0009976 -3 [C[T>G]G] Strong resistance 0.229 0.362 0.216 0.193 0.131 0.472936426838 1.61 NO V101G 1.03e-05 -3 [G[T>G]A] Strong resistance 0.294 0.315 0.299 0.092 0.131 0.472734808438 -0.44 NO K55T 3.59e-05 -1 [A[A>C]A] Strong resistance 0.275 0.329 0.279 0.117 0.131 0.472525930045 -0.23 NO K114M 0.000114 -1 [A[A>T]G] Resistance 0.483 0.14 0.242 0.136 0.131 0.471319191282 -0.42 NO T190A 0.0003212 0 [C[A>G]C] Resistance 0.337 0.27 0.253 0.14 0.13 0.470798001382 0.17 NO K54N 0.0002104 0 [A[G>T]A] Strong resistance 0.26 0.342 0.285 0.113 0.13 0.470704629983 1.88 NO K54N 0.0001073 0 [A[G>C]A] Strong resistance 0.26 0.342 0.285 0.113 0.13 0.470704629983 1.88 NO L170P 0.0012621 -3 [C[T>C]G] Strong resistance 0.224 0.373 0.279 0.124 0.13 0.469529836765 1.77 NO N154K 8.17e-05 0 [A[C>G]C] Strong resistance 0.256 0.343 0.266 0.135 0.13 0.469333619468 1.88 NO N154K 0.0006416 0 [A[C>A]C] Strong resistance 0.256 0.343 0.266 0.135 0.13 0.469333619468 1.88 NO I103K 0.0010456 -3 [A[T>A]A] Strong resistance 0.258 0.343 0.283 0.115 0.13 0.469253016788 1.72 NO M108T 0.000965 -1 [A[T>C]G] Strong resistance 0.253 0.347 0.279 0.121 0.13 0.468904684203 1.53 NO T190K 0.0005893 -1 [A[C>A]A] Resistance 0.348 0.262 0.273 0.117 0.129 0.467667820042 0.17 NO L155M 0.0013983 2 [C[C>A]T] Resistance 0.334 0.27 0.235 0.161 0.129 0.467125252859 -0.15 NO Q17P 0.0001451 -1 [C[A>C]G] Resistance 0.341 0.265 0.258 0.135 0.129 0.465855795474 -0.66 NO C40F 0.0002441 -2 [T[G>T]C] Strong resistance 0.269 0.334 0.297 0.099 0.128 0.465181652447 -0.39 NO F19C 0.0010349 -2 [T[T>G]C] Strong resistance 0.302 0.304 0.291 0.103 0.128 0.465042009971 -0.63 NO I53T 0.0003081 -1 [A[T>C]C] Strong resistance 0.267 0.336 0.303 0.094 0.128 0.464798623264 1.35 NO G85E 0.0009652 -2 [G[G>A]A] Resistance 0.376 0.236 0.276 0.112 0.128 0.464066308851 -0.39 NO R50Q 0.0011407 1 [C[G>A]A] Resistance 0.31 0.294 0.271 0.125 0.128 0.464004066421 -0.42 NO K164R 0.0003019 2 [A[A>G]G] Resistance 0.378 0.234 0.274 0.114 0.128 0.463359491217 1.0 NO N87D 0.0001599 1 [C[A>G]A] Resistance 0.436 0.185 0.294 0.085 0.128 0.463280597246 -0.39 NO A42S 0.0002441 1 [T[G>T]C] Strong resistance 0.201 0.393 0.289 0.118 0.127 0.462787017109 -0.58 NO I83F 0.0002346 0 [C[A>T]T] Strong resistance 0.179 0.411 0.284 0.127 0.127 0.461137861182 1.56 NO D167H 3.83e-05 -1 [T[G>C]A] Strong resistance 0.278 0.318 0.245 0.159 0.127 0.460572059248 3.21 NO K151E 0.0001599 1 [C[A>G]A] Resistance 0.38 0.231 0.272 0.118 0.126 0.45999797117 2.28 NO L150R 0.0008952 -2 [C[T>G]C] Strong resistance 0.253 0.34 0.24 0.168 0.126 0.459672379489 3.05 NO Q105E 0.0001073 2 [A[C>G]A] Strong resistance 0.282 0.319 0.292 0.107 0.125 0.457693603039 -0.5 NO D106N 0.0009652 1 [G[G>A]A] Resistance 0.31 0.293 0.287 0.109 0.125 0.457371853485 2.01 NO I83L 0.001356 2 [C[A>C]T] Strong resistance 0.168 0.42 0.291 0.121 0.125 0.45724111012 1.56 NO Q17R 0.0003148 1 [C[A>G]G] Strong resistance 0.282 0.319 0.292 0.107 0.125 0.456460074217 -0.66 NO R50L 0.0001423 -2 [C[G>T]A] Resistance 0.383 0.226 0.269 0.122 0.125 0.456432363602 -0.42 NO L155Q 0.0007718 -2 [C[T>A]G] Resistance 0.321 0.28 0.257 0.143 0.124 0.455116460151 -0.15 NO Y113C 0.0001817 -2 [T[A>G]C] Resistance 0.366 0.238 0.256 0.14 0.124 0.452904166304 -0.31 NO K55E 0.0002063 1 [G[A>G]A] Resistance 0.343 0.262 0.279 0.116 0.123 0.452221630581 -0.23 NO I53F 0.0001345 0 [T[A>T]T] Strong resistance 0.279 0.321 0.307 0.093 0.123 0.450156284682 1.35 NO K54E 0.0001599 1 [C[A>G]A] Strong resistance 0.254 0.34 0.285 0.121 0.123 0.450005498027 1.88 NO H147L 0.0001276 -3 [C[A>T]C] Strong resistance 0.276 0.324 0.312 0.088 0.123 0.4499136914 2.65 NO C40R 0.0004789 -3 [G[T>C]G] Strong resistance 0.242 0.352 0.297 0.109 0.122 0.449236767951 -0.39 NO I53N 0.0008346 -3 [A[T>A]C] Strong resistance 0.268 0.33 0.306 0.096 0.122 0.448535673832 1.35 NO V101E 5.15e-05 -2 [G[T>A]A] Strong resistance 0.268 0.33 0.306 0.096 0.122 0.448352304913 -0.44 NO N158Y 4.94e-05 -2 [C[A>T]A] Resistance 0.386 0.221 0.27 0.124 0.122 0.447647472473 -0.15 NO K117N 0.0002104 0 [A[G>T]A] Resistance 0.529 0.088 0.225 0.158 0.121 0.447107002111 -0.52 NO K117N 0.0001073 0 [A[G>C]A] Resistance 0.529 0.088 0.225 0.158 0.121 0.447107002111 -0.52 NO K54Q 1.49e-05 1 [C[A>C]A] Strong resistance 0.247 0.341 0.253 0.159 0.121 0.446274415963 1.88 NO M38R 0.0009162 -1 [A[T>G]G] Strong resistance 0.277 0.321 0.303 0.099 0.121 0.446231260528 -0.23 NO F168L 0.0010302 0 [T[T>G]G] Resistance 0.302 0.282 0.171 0.245 0.12 0.444190192993 2.76 NO F168L 0.0049426 0 [C[T>C]T] Resistance 0.302 0.282 0.171 0.245 0.12 0.444190192993 2.76 NO F168L 0.0009984 0 [T[T>A]G] Resistance 0.302 0.282 0.171 0.245 0.12 0.444190192993 2.76 NO S57C 0.0001087 -1 [C[A>T]G] Resistance 0.403 0.202 0.252 0.143 0.12 0.443702687791 -0.58 NO Y113H 0.0023694 2 [T[T>C]A] Resistance 0.368 0.234 0.256 0.142 0.12 0.443222114862 -0.31 NO I56N 0.0008346 -3 [A[T>A]C] Strong resistance 0.262 0.331 0.294 0.113 0.12 0.442217698497 0.6 NO N87K 0.0009162 0 [A[T>G]G] Resistance 0.415 0.193 0.274 0.118 0.119 0.441298154413 -0.39 NO N87K 0.0009666 0 [A[T>A]G] Resistance 0.415 0.193 0.274 0.118 0.119 0.441298154413 -0.39 NO I103T 0.0008401 -1 [A[T>C]A] Strong resistance 0.245 0.346 0.296 0.112 0.119 0.440262788654 1.72 NO V51E 5.15e-05 -2 [G[T>A]A] Strong resistance 0.285 0.309 0.287 0.12 0.117 0.436690739658 0.01 NO N87Y 4.94e-05 -2 [C[A>T]A] Resistance 0.414 0.193 0.279 0.114 0.117 0.436567473598 -0.39 NO A42V 0.0155456 0 [G[C>T]T] Strong resistance 0.204 0.38 0.287 0.129 0.117 0.435634323127 -0.58 NO T68A 0.0002134 0 [A[A>G]C] Strong resistance 0.295 0.297 0.277 0.13 0.117 0.435231830423 -0.1 NO D149E 8.17e-05 2 [A[C>G]C] Resistance 0.398 0.194 0.178 0.23 0.117 0.434156383913 3.19 NO D149E 0.0006416 2 [A[C>A]C] Resistance 0.398 0.194 0.178 0.23 0.117 0.434156383913 3.19 NO I31S 6.16e-05 -2 [A[T>G]C] sensitivity 0.28 0.319 0.34 0.062 0.116 0.433627505224 1.53 NO V101L 0.000101 1 [T[G>C]T] Strong resistance 0.263 0.329 0.311 0.097 0.116 0.432801563385 -0.44 NO V101L 0.0002911 1 [T[G>T]T] Strong resistance 0.263 0.329 0.311 0.097 0.116 0.432801563385 -0.44 NO D111Y 0.0002104 -3 [A[G>T]A] Resistance 0.299 0.295 0.296 0.11 0.116 0.431518416692 0.68 NO S153Y 0.0021386 -2 [T[C>A]C] Strong resistance 0.283 0.306 0.266 0.145 0.116 0.431512740469 0.41 NO S153F 0.2738526 -2 [T[C>T]C] Strong resistance 0.293 0.296 0.26 0.151 0.115 0.431026516116 0.41 NO N154T 6.16e-05 0 [A[A>C]C] Resistance 0.307 0.283 0.264 0.145 0.115 0.429776888164 1.88 NO L156M 0.0002262 2 [G[C>A]T] Resistance 0.351 0.243 0.257 0.148 0.115 0.428918595167 1.99 NO I165V 0.0002356 3 [G[A>G]T] Strong resistance 0.194 0.385 0.278 0.143 0.114 0.427605485122 -0.15 NO K117M 0.000114 -1 [A[A>T]G] Resistance 0.469 0.134 0.222 0.176 0.113 0.425812984991 -0.52 NO I84S 0.0002008 -2 [A[T>G]T] Strong resistance 0.265 0.325 0.312 0.098 0.113 0.425100669372 2.28 NO N154Y 4.94e-05 -2 [C[A>T]A] Strong resistance 0.271 0.317 0.292 0.119 0.113 0.424347410294 1.88 NO F19S 0.0019071 -2 [T[T>C]C] Resistance 0.34 0.254 0.284 0.121 0.113 0.423683156872 -0.63 NO L75S 0.0023694 -2 [T[T>C]A] Resistance 0.316 0.273 0.269 0.142 0.111 0.419594947102 0.81 NO I103L 0.0001345 2 [T[A>T]T] Strong resistance 0.249 0.337 0.314 0.1 0.11 0.41769955596 1.72 NO I103L 0.0003987 2 [T[A>C]T] Strong resistance 0.249 0.337 0.314 0.1 0.11 0.41769955596 1.72 NO K55Q 1.03e-05 1 [G[A>C]A] Resistance 0.322 0.264 0.249 0.165 0.11 0.4164401358 -0.23 NO K54T 6.37e-05 -1 [A[A>C]G] Strong resistance 0.205 0.372 0.291 0.132 0.11 0.416294894762 1.88 NO C40W 5.15e-05 -2 [G[C>G]T] Strong resistance 0.249 0.335 0.313 0.103 0.108 0.412955027632 -0.39 NO K117T 6.37e-05 -1 [A[A>C]G] Resistance 0.465 0.132 0.222 0.181 0.108 0.412038012767 -0.52 NO V101A 0.0004183 0 [G[T>C]A] Strong resistance 0.271 0.313 0.297 0.119 0.108 0.411477469653 -0.44 NO N158K 0.0001073 0 [A[C>G]A] Resistance 0.392 0.203 0.277 0.128 0.108 0.411368880894 -0.15 NO N158K 0.0005893 0 [A[C>A]A] Resistance 0.392 0.203 0.277 0.128 0.108 0.411368880894 -0.15 NO K54M 0.000114 -1 [A[A>T]G] Strong resistance 0.205 0.373 0.306 0.117 0.108 0.411330884173 1.88 NO C40Y 0.0039555 -2 [T[G>A]C] Strong resistance 0.251 0.331 0.302 0.115 0.108 0.411060208733 -0.39 NO V39E 0.0006446 -2 [G[T>A]G] Strong resistance 0.252 0.333 0.326 0.089 0.107 0.409475674225 1.75 NO E71V 7.62e-05 -2 [G[A>T]G] Resistance 0.304 0.281 0.286 0.13 0.106 0.407277334058 1.77 NO V51L 0.0001349 1 [A[G>T]T] Strong resistance 0.268 0.313 0.292 0.127 0.106 0.405891656292 0.01 NO V51L 0.0001223 1 [A[G>C]T] Strong resistance 0.268 0.313 0.292 0.127 0.106 0.405891656292 0.01 NO R67S 5.15e-05 -1 [G[A>T]A] Resistance 0.431 0.166 0.278 0.125 0.105 0.40408388083 0.06 NO R67S 1.03e-05 -1 [G[A>C]A] Resistance 0.431 0.166 0.278 0.125 0.105 0.40408388083 0.06 NO Y30F 7.09e-05 3 [T[A>T]C] Resistance 0.334 0.25 0.255 0.162 0.105 0.403903521568 -0.66 NO C65W 0.0004393 -2 [G[C>G]C] Resistance 0.293 0.287 0.273 0.146 0.105 0.402800303335 -0.66 NO I53L 0.0003987 2 [T[A>C]T] sensitivity 0.26 0.323 0.328 0.089 0.105 0.402622274691 1.35 NO A52V 0.0155456 0 [G[C>T]T] Strong resistance 0.162 0.413 0.345 0.08 0.104 0.402563399284 1.85 NO D111E 6.16e-05 2 [A[T>G]C] Resistance 0.309 0.265 0.216 0.21 0.103 0.399689997758 0.68 NO D111E 0.0008346 2 [A[T>A]C] Resistance 0.309 0.265 0.216 0.21 0.103 0.399689997758 0.68 NO I83V 0.0006799 3 [C[A>G]T] Strong resistance 0.147 0.417 0.294 0.141 0.103 0.39742874139 1.56 NO L157I 0.0002262 2 [G[C>A]T] sensitivity 0.267 0.317 0.342 0.074 0.102 0.39688046939 0.12 NO G32R 3.78e-05 -2 [C[G>C]G] Resistance 0.393 0.202 0.323 0.081 0.102 0.396519034922 1.48 NO L112F 0.0802505 0 [T[C>T]T] sensitivity 0.291 0.29 0.297 0.122 0.102 0.396037280252 -0.31 NO I56T 0.0003081 -1 [A[T>C]C] Strong resistance 0.256 0.322 0.316 0.106 0.101 0.394422682315 0.6 NO D106G 0.0001711 -1 [G[A>G]C] Resistance 0.303 0.276 0.282 0.139 0.1 0.391468066454 2.01 NO A35S 0.0001432 1 [C[G>T]C] Strong resistance 0.266 0.309 0.293 0.132 0.1 0.389920902451 -0.04 NO S57G 0.0003148 0 [C[A>G]G] Resistance 0.387 0.199 0.268 0.146 0.099 0.389098256283 -0.58 NO S41C 0.0007641 -1 [T[C>G]T] sensitivity 0.298 0.281 0.3 0.121 0.099 0.389089528472 -0.52 NO C65Y 0.0039555 -2 [T[G>A]C] Resistance 0.299 0.278 0.278 0.145 0.099 0.387578061974 -0.66 NO C65F 0.0002441 -2 [T[G>T]C] Resistance 0.299 0.277 0.277 0.148 0.098 0.386776561668 -0.66 NO T68I 0.0188993 -1 [A[C>T]C] Strong resistance 0.217 0.356 0.332 0.095 0.098 0.385856666888 -0.1 NO L156Q 0.0007718 -2 [C[T>A]G] Resistance 0.327 0.251 0.278 0.145 0.097 0.383297618502 1.99 NO Y113F 7.09e-05 3 [T[A>T]C] Resistance 0.452 0.137 0.248 0.164 0.097 0.383088684029 -0.31 NO A52D 0.0002262 -2 [G[C>A]T] Strong resistance 0.23 0.341 0.317 0.112 0.097 0.382069885416 1.85 NO T190I 0.0004688 -1 [A[C>T]A] sensitivity 0.3 0.28 0.329 0.092 0.096 0.379957440884 0.17 NO L156V 5.15e-05 1 [G[C>G]T] sensitivity 0.269 0.307 0.329 0.094 0.096 0.379811560127 1.99 NO K164N 0.0001073 0 [A[G>C]A] Resistance 0.339 0.241 0.298 0.122 0.096 0.378999283448 1.0 NO K164N 0.0002104 0 [A[G>T]A] Resistance 0.339 0.241 0.298 0.122 0.096 0.378999283448 1.0 NO Y36S 8.76e-05 -2 [T[A>C]C] sensitivity 0.291 0.286 0.32 0.102 0.095 0.378418798841 0.52 NO N87S 0.000269 1 [A[A>G]T] Resistance 0.331 0.251 0.326 0.091 0.095 0.378309564515 -0.39 NO A42D 0.0002262 -2 [G[C>A]T] Strong resistance 0.269 0.3 0.277 0.153 0.095 0.378221161521 -0.58 NO S29W 0.0003015 -3 [T[C>G]G] Resistance 0.369 0.211 0.279 0.141 0.095 0.377443163714 -0.66 NO I56F 0.0001647 0 [A[A>T]T] sensitivity 0.258 0.314 0.316 0.111 0.095 0.376415047179 0.6 NO S41P 0.001079 -1 [C[T>C]C] sensitivity 0.282 0.291 0.3 0.127 0.094 0.375637639479 -0.52 NO E109Q 4.34e-05 2 [G[G>C]A] Resistance 0.387 0.196 0.289 0.128 0.094 0.375384070768 -0.39 NO K114N 0.0001679 0 [A[G>T]C] Resistance 0.476 0.115 0.279 0.13 0.093 0.373616605328 -0.42 NO K114N 8.17e-05 0 [A[G>C]C] Resistance 0.476 0.115 0.279 0.13 0.093 0.373616605328 -0.42 NO A42P 9.33e-05 -1 [T[G>C]C] Strong resistance 0.274 0.294 0.282 0.15 0.093 0.372029860706 -0.58 NO D106Y 0.0001909 -3 [G[G>T]A] Resistance 0.319 0.255 0.305 0.12 0.091 0.36681578543 2.01 NO A42T 0.0039555 0 [T[G>A]C] Strong resistance 0.278 0.288 0.286 0.149 0.089 0.361229479722 -0.58 NO K55I 9.84e-05 -3 [A[A>T]A] Strong resistance 0.234 0.33 0.317 0.119 0.088 0.360243936416 -0.23 NO S57N 0.0027136 1 [A[G>A]C] Resistance 0.351 0.225 0.313 0.111 0.088 0.359385385541 -0.58 NO N158D 0.0001599 1 [C[A>G]A] Resistance 0.357 0.221 0.326 0.096 0.088 0.358304667812 -0.15 NO I56L 0.0002008 2 [A[A>C]T] sensitivity 0.253 0.314 0.331 0.102 0.087 0.357970587138 0.6 NO A42G 5.15e-05 0 [G[C>G]T] Resistance 0.372 0.205 0.305 0.118 0.087 0.356802808317 -0.58 NO V104E 5.15e-05 -2 [G[T>A]A] sensitivity 0.254 0.31 0.313 0.123 0.087 0.356098784518 0.57 NO D106E 8.17e-05 2 [A[C>G]C] Resistance 0.366 0.202 0.245 0.186 0.087 0.355838687959 2.01 NO D106E 0.0006416 2 [A[C>A]C] Resistance 0.366 0.202 0.245 0.186 0.087 0.355838687959 2.01 NO C65R 0.0012621 -3 [C[T>C]G] Resistance 0.295 0.27 0.283 0.152 0.086 0.355297590906 -0.66 NO T190S 0.0001276 1 [C[A>T]C] sensitivity 0.311 0.263 0.34 0.086 0.086 0.355204235935 0.17 NO K114Q 1.49e-05 1 [C[A>C]A] Resistance 0.463 0.114 0.228 0.196 0.086 0.353989407985 -0.42 NO K114E 0.0001599 1 [C[A>G]A] Resistance 0.506 0.077 0.244 0.172 0.086 0.353889359463 -0.42 NO L157V 5.15e-05 1 [G[C>G]T] sensitivity 0.212 0.353 0.362 0.074 0.086 0.353502223017 0.12 NO A52T 0.0027136 0 [A[G>A]C] Strong resistance 0.225 0.337 0.331 0.107 0.086 0.35306299988 1.85 NO Y113D 4.4e-05 -3 [T[T>G]A] Resistance 0.391 0.183 0.277 0.149 0.085 0.352684639782 -0.31 NO E109V 5.15e-05 -2 [G[A>T]A] sensitivity 0.316 0.256 0.333 0.094 0.085 0.351883464543 -0.39 NO M38V 0.0006799 1 [C[A>G]T] sensitivity 0.218 0.347 0.364 0.072 0.085 0.351566465638 -0.23 NO L112H 0.0019397 -3 [C[T>A]T] sensitivity 0.281 0.284 0.308 0.127 0.085 0.35110770034 -0.31 NO E71Q 4.34e-05 2 [G[G>C]A] Resistance 0.369 0.2 0.266 0.165 0.085 0.350647854954 1.77 NO Y64C 0.0001817 -2 [T[A>G]C] Resistance 0.312 0.254 0.294 0.14 0.084 0.34887392602 -0.52 NO V39L 0.0001315 1 [G[G>T]T] sensitivity 0.229 0.334 0.352 0.085 0.083 0.347125380196 1.75 NO V39L 5.15e-05 1 [G[G>C]T] sensitivity 0.229 0.334 0.352 0.085 0.083 0.347125380196 1.75 NO R50G 0.0003015 -2 [T[C>G]G] sensitivity 0.282 0.284 0.328 0.107 0.083 0.346917772557 -0.42 NO A52G 5.15e-05 0 [G[C>G]T] sensitivity 0.315 0.255 0.327 0.104 0.083 0.346745878256 1.85 NO I86S 6.16e-05 -2 [A[T>G]C] sensitivity 0.317 0.255 0.348 0.08 0.083 0.346382690574 0.95 NO A52P 8.17e-05 -1 [A[G>C]C] Strong resistance 0.23 0.329 0.324 0.117 0.083 0.345493912089 1.85 NO L75I 0.0019397 2 [C[T>A]T] Resistance 0.365 0.207 0.314 0.113 0.082 0.344408201606 0.81 NO K117Q 1.03e-05 1 [G[A>C]A] Resistance 0.454 0.111 0.175 0.26 0.082 0.344310776176 -0.52 NO D149V 4.71e-05 -3 [G[A>T]C] sensitivity 0.32 0.246 0.321 0.113 0.08 0.339308233841 3.19 NO V104G 1.03e-05 -3 [G[T>G]A] sensitivity 0.255 0.303 0.316 0.126 0.08 0.338741216637 0.57 NO L115F 0.0155456 0 [G[C>T]T] Resistance 0.395 0.175 0.288 0.141 0.08 0.337890713221 -0.44 NO Y113N 0.0010661 -2 [T[T>A]A] Resistance 0.382 0.185 0.28 0.152 0.08 0.337680947518 -0.31 NO F19Y 0.0014918 3 [T[T>A]C] sensitivity 0.276 0.29 0.359 0.075 0.08 0.337336755768 -0.63 NO Y64H 0.0011072 2 [C[T>C]A] Resistance 0.326 0.237 0.296 0.141 0.079 0.336328310808 -0.52 NO Q17E 4.34e-05 2 [G[C>G]A] sensitivity 0.304 0.259 0.314 0.123 0.079 0.336022393808 -0.66 NO D111H 0.0001073 -1 [A[G>C]A] Strong resistance 0.252 0.297 0.255 0.195 0.079 0.335951841961 0.68 NO G32D 0.0025766 -1 [G[G>A]C] sensitivity 0.332 0.237 0.35 0.081 0.078 0.332532484505 1.48 NO V104L 0.0001349 1 [A[G>T]T] sensitivity 0.25 0.307 0.332 0.111 0.078 0.332040738359 0.57 NO V104L 0.0001223 1 [A[G>C]T] sensitivity 0.25 0.307 0.332 0.111 0.078 0.332040738359 0.57 NO A35D 0.0002341 -2 [G[C>A]C] Resistance 0.32 0.24 0.288 0.152 0.078 0.33197370264 -0.04 NO P58A 0.0004366 -1 [C[C>G]C] Resistance 0.291 0.262 0.263 0.184 0.077 0.331339983018 -0.6 NO S29L 0.094867 -2 [T[C>T]G] Resistance 0.358 0.208 0.31 0.125 0.077 0.32950235641 -0.66 NO K117E 0.0002063 1 [G[A>G]A] Resistance 0.49 0.076 0.197 0.236 0.076 0.328787277738 -0.52 NO D149H 3.83e-05 -1 [T[G>C]A] Resistance 0.321 0.228 0.212 0.239 0.076 0.326791607688 3.19 NO S57T 8.17e-05 1 [A[G>C]C] Resistance 0.418 0.147 0.259 0.175 0.076 0.326723797529 -0.58 NO I165S 6.16e-05 -2 [A[T>G]C] sensitivity 0.206 0.347 0.365 0.081 0.075 0.324377978825 -0.15 NO V104A 0.0004183 0 [G[T>C]A] sensitivity 0.254 0.299 0.316 0.131 0.074 0.323686557223 0.57 NO G32A 6.04e-05 0 [G[G>C]C] sensitivity 0.339 0.231 0.378 0.052 0.074 0.323290699474 1.48 NO N154S 0.0002134 1 [A[A>G]C] sensitivity 0.222 0.329 0.336 0.113 0.074 0.321984057554 1.88 NO N154I 7.68e-05 -3 [A[A>T]C] sensitivity 0.239 0.314 0.342 0.105 0.073 0.32034847627 1.88 NO Y64F 7.09e-05 3 [T[A>T]C] Resistance 0.415 0.149 0.269 0.167 0.073 0.319947233399 -0.52 NO A35T 0.0037249 0 [C[G>A]C] Resistance 0.32 0.236 0.298 0.146 0.072 0.318054814171 -0.04 NO L170Q 0.0007718 -2 [C[T>A]G] Resistance 0.322 0.229 0.259 0.19 0.072 0.316596689577 1.77 NO S153T 0.0014918 1 [T[T>A]C] Resistance 0.296 0.25 0.25 0.204 0.072 0.316044512427 0.41 NO G32C 4.87e-05 -3 [C[G>T]G] sensitivity 0.33 0.234 0.361 0.075 0.071 0.315869664201 1.48 NO G169A 6.04e-05 0 [G[G>C]C] sensitivity 0.275 0.274 0.293 0.157 0.071 0.315424637508 2.89 NO L107R 0.0008952 -2 [C[T>G]C] sensitivity 0.29 0.261 0.298 0.15 0.071 0.315253851348 0.12 NO G169V 0.0001393 -3 [G[G>T]C] Strong resistance 0.194 0.348 0.306 0.153 0.071 0.314095618629 2.89 NO L157R 0.0008952 -2 [C[T>G]C] Strong resistance 0.22 0.324 0.306 0.15 0.071 0.31367530076 0.12 NO G169S 0.0010782 0 [T[G>A]G] Resistance 0.38 0.181 0.301 0.137 0.07 0.313239427817 2.89 NO N158T 6.16e-05 0 [A[A>C]C] Resistance 0.368 0.188 0.267 0.178 0.07 0.311823859381 -0.15 NO K114T 6.37e-05 -1 [A[A>C]G] Resistance 0.396 0.164 0.285 0.155 0.069 0.30866733603 -0.42 NO S41F 0.0802505 -2 [T[C>T]T] sensitivity 0.295 0.258 0.326 0.121 0.069 0.308439889333 -0.52 NO T63I 0.0188993 -1 [A[C>T]C] Resistance 0.41 0.156 0.324 0.111 0.068 0.307150323918 -0.47 NO C40G 0.001701 -3 [G[T>G]G] Strong resistance 0.203 0.33 0.249 0.219 0.068 0.305955936783 -0.39 NO L112I 0.0015225 2 [T[C>A]T] sensitivity 0.33 0.226 0.346 0.098 0.065 0.299698268105 -0.31 NO N158S 0.0002134 1 [A[A>G]C] sensitivity 0.307 0.246 0.341 0.106 0.065 0.299322415781 -0.15 NO L115H 0.0014538 -3 [C[T>A]C] Resistance 0.368 0.185 0.296 0.151 0.064 0.295433517567 -0.44 NO T110A 0.0002134 0 [A[A>G]C] Strong resistance 0.251 0.286 0.272 0.192 0.063 0.293684750154 -0.39 NO I53V 0.0001954 3 [T[A>G]T] sensitivity 0.234 0.311 0.356 0.099 0.063 0.292729172261 1.35 NO D111V 7.08e-05 -3 [G[A>T]T] sensitivity 0.238 0.306 0.351 0.105 0.063 0.292447080419 0.68 NO K164M 0.000114 -1 [A[A>T]G] sensitivity 0.262 0.281 0.324 0.133 0.062 0.291506853706 1.0 NO E109A 1.03e-05 -1 [G[A>C]A] Strong resistance 0.238 0.297 0.282 0.184 0.062 0.2900406979 -0.39 NO S29T 0.0014538 1 [C[T>A]C] Resistance 0.382 0.169 0.286 0.162 0.061 0.289636584647 -0.66 NO I103V 0.0001954 3 [T[A>G]T] Strong resistance 0.208 0.326 0.301 0.165 0.061 0.289385729153 1.72 NO L170V 0.00036 1 [C[C>G]T] sensitivity 0.275 0.271 0.337 0.117 0.061 0.289378321443 1.77 NO K164E 0.0001599 1 [C[A>G]A] Resistance 0.331 0.217 0.308 0.145 0.061 0.288023061397 1.0 NO N87I 0.0001647 -3 [A[A>T]T] Resistance 0.369 0.187 0.348 0.096 0.059 0.283568730287 -0.39 NO N87H 1.49e-05 1 [C[A>C]A] Resistance 0.393 0.163 0.336 0.108 0.059 0.281849966558 -0.39 NO S41Y 0.0015225 -2 [T[C>A]T] sensitivity 0.293 0.251 0.332 0.124 0.058 0.28168473232 -0.52 NO N87T 0.0002008 0 [A[A>C]T] Resistance 0.382 0.163 0.294 0.161 0.054 0.269497102119 -0.39 NO A35P 5.77e-05 -1 [C[G>C]C] sensitivity 0.327 0.216 0.33 0.127 0.054 0.269120060177 -0.04 NO G169R 1.73e-05 -2 [T[G>C]G] Resistance 0.308 0.228 0.296 0.168 0.053 0.266864853479 2.89 NO F19V 0.0011812 -1 [G[T>G]T] sensitivity 0.257 0.283 0.369 0.092 0.053 0.26649973242 -0.63 NO N158I 7.68e-05 -3 [A[A>T]C] Resistance 0.356 0.192 0.352 0.1 0.052 0.265428151219 -0.15 NO Y30S 8.76e-05 -2 [T[A>C]C] sensitivity 0.304 0.238 0.355 0.103 0.052 0.26514223491 -0.66 NO P152A 0.0004393 -1 [G[C>G]C] Strong resistance 0.224 0.293 0.227 0.256 0.051 0.26344141532 1.4 NO S57I 0.0001679 -2 [A[G>T]C] Resistance 0.391 0.159 0.345 0.104 0.051 0.262957301135 -0.58 NO K164Q 1.49e-05 1 [C[A>C]A] Resistance 0.294 0.237 0.275 0.194 0.051 0.262827415024 1.0 NO I56V 0.000269 3 [A[A>G]T] sensitivity 0.218 0.308 0.317 0.156 0.051 0.261784240639 0.6 NO A35G 0.0004393 0 [G[C>G]C] sensitivity 0.333 0.208 0.335 0.124 0.05 0.259230895693 -0.04 NO I83S 6.16e-05 -2 [A[T>G]C] Strong resistance 0.125 0.397 0.375 0.103 0.05 0.258761693046 1.56 NO R50P 6.44e-05 -2 [C[G>C]A] sensitivity 0.318 0.224 0.359 0.099 0.05 0.258432795704 -0.42 NO L170M 0.0013983 2 [C[C>A]T] Resistance 0.329 0.2 0.247 0.224 0.049 0.257110715083 1.77 NO L155R 0.0009976 -2 [C[T>G]G] sensitivity 0.248 0.282 0.33 0.14 0.049 0.256631059702 -0.15 NO K164T 6.37e-05 -1 [A[A>C]G] sensitivity 0.259 0.271 0.326 0.144 0.049 0.256378343441 1.0 NO D106H 4.34e-05 -1 [G[G>C]A] Resistance 0.292 0.236 0.271 0.201 0.049 0.256107602455 2.01 NO L115V 5.15e-05 1 [G[C>G]T] sensitivity 0.342 0.199 0.353 0.105 0.047 0.250826450546 -0.44 NO R67I 0.0002104 -3 [A[G>T]A] sensitivity 0.309 0.226 0.336 0.128 0.047 0.250353427165 0.06 NO A35V 0.0202731 0 [G[C>T]C] sensitivity 0.28 0.253 0.358 0.109 0.045 0.246734649085 -0.04 NO N158H 1.49e-05 1 [C[A>C]A] Resistance 0.355 0.183 0.338 0.124 0.043 0.24221565475 -0.15 NO T110R 0.0001073 -1 [A[C>G]A] sensitivity 0.285 0.247 0.361 0.107 0.043 0.240135278929 -0.39 NO C40S 9.33e-05 -1 [T[G>C]C] sensitivity 0.234 0.292 0.376 0.098 0.04 0.234365632418 -0.39 NO C40S 0.0006446 -1 [G[T>A]G] sensitivity 0.234 0.292 0.376 0.098 0.04 0.234365632418 -0.39 NO Y64N 4.94e-05 -2 [C[T>A]A] Resistance 0.335 0.195 0.319 0.151 0.04 0.233692413044 -0.52 NO T110K 0.0005893 -1 [A[C>A]A] sensitivity 0.277 0.252 0.368 0.103 0.04 0.233184492102 -0.39 NO I53S 6.16e-05 -2 [A[T>G]C] sensitivity 0.225 0.302 0.399 0.075 0.039 0.231073802677 1.35 NO R67T 0.0001073 -1 [A[G>C]A] sensitivity 0.31 0.217 0.326 0.147 0.039 0.230147274348 0.06 NO Y64D 1.49e-05 -3 [C[T>G]A] Resistance 0.341 0.189 0.321 0.149 0.039 0.229918897724 -0.52 NO S41T 0.0014538 1 [C[T>A]C] sensitivity 0.298 0.226 0.312 0.164 0.039 0.229652318926 -0.52 NO N154H 1.49e-05 1 [C[A>C]A] sensitivity 0.234 0.287 0.348 0.132 0.039 0.229369210948 1.88 NO L155V 0.00036 1 [C[C>G]T] sensitivity 0.241 0.286 0.408 0.066 0.036 0.222781621437 -0.15 NO Q105H 2.76e-05 0 [A[G>T]G] sensitivity 0.248 0.276 0.379 0.098 0.036 0.22257965442 -0.5 NO Q105H 1.91e-05 0 [A[G>C]G] sensitivity 0.248 0.276 0.379 0.098 0.036 0.22257965442 -0.5 NO L75V 0.0025875 1 [C[T>G]T] sensitivity 0.297 0.23 0.362 0.111 0.035 0.220953726262 0.81 NO G169D 0.0025766 -1 [G[G>A]C] sensitivity 0.248 0.265 0.305 0.182 0.034 0.217822566931 2.89 NO M38T 0.000965 -1 [A[T>C]G] sensitivity 0.197 0.317 0.375 0.112 0.032 0.212713889671 -0.23 NO T63A 0.0001711 0 [G[A>G]C] Resistance 0.4 0.121 0.302 0.176 0.026 0.195953925666 -0.47 NO R67G 0.0001519 -2 [G[A>G]G] sensitivity 0.242 0.267 0.357 0.135 0.024 0.190398961565 0.06 NO L156R 0.0009976 -2 [C[T>G]G] sensitivity 0.261 0.247 0.334 0.158 0.024 0.190085345885 1.99 NO F19L 0.0003015 0 [T[C>G]G] sensitivity 0.239 0.252 0.264 0.245 0.018 0.175155217079 -0.63 NO F19L 0.0079602 0 [G[T>C]T] sensitivity 0.239 0.252 0.264 0.245 0.018 0.175155217079 -0.63 NO F19L 0.0002472 0 [T[C>A]G] sensitivity 0.239 0.252 0.264 0.245 0.018 0.175155217079 -0.63 NO E109G 0.0002063 -2 [G[A>G]A] sensitivity 0.252 0.248 0.326 0.174 0.017 0.174117878088 -0.39 NO I56S 6.16e-05 -2 [A[T>G]C] sensitivity 0.211 0.294 0.404 0.091 0.017 0.172588598699 0.6 NO C65G 0.0009976 -3 [C[T>G]G] neutral 0.257 0.23 0.222 0.291 0.017 0.171681010709 -0.66 NO D106V 4.71e-05 -3 [G[A>T]C] sensitivity 0.264 0.241 0.377 0.117 0.015 0.168167974759 2.01 NO Q17H 1.91e-05 0 [A[G>C]G] sensitivity 0.279 0.229 0.387 0.105 0.015 0.167799612635 -0.66 NO Q17H 2.76e-05 0 [A[G>T]G] sensitivity 0.279 0.229 0.387 0.105 0.015 0.167799612635 -0.66 NO C65S 9.33e-05 -1 [T[G>C]C] sensitivity 0.285 0.219 0.363 0.133 0.013 0.162996940476 -0.66 NO C65S 0.0007718 -1 [C[T>A]G] sensitivity 0.285 0.219 0.363 0.133 0.013 0.162996940476 -0.66 NO Q105K 0.0005893 1 [A[C>A]A] sensitivity 0.24 0.263 0.401 0.096 0.012 0.159871039785 -0.5 NO M38I 0.0010782 1 [T[G>A]G] sensitivity 0.197 0.303 0.434 0.065 0.01 0.155018936034 -0.23 NO M38I 1.73e-05 1 [T[G>C]G] sensitivity 0.197 0.303 0.434 0.065 0.01 0.155018936034 -0.23 NO M38I 5.77e-05 1 [T[G>T]G] sensitivity 0.197 0.303 0.434 0.065 0.01 0.155018936034 -0.23 NO T110S 7.68e-05 1 [A[A>T]C] sensitivity 0.231 0.268 0.404 0.096 0.009 0.151230720606 -0.39 NO V101I 0.00245 3 [T[G>A]T] sensitivity 0.155 0.341 0.45 0.054 0.008 0.149613777362 -0.44 NO L112R 0.0025875 -2 [C[T>G]T] sensitivity 0.24 0.25 0.323 0.188 0.008 0.148966758243 -0.31 NO L115I 0.0002262 2 [G[C>A]T] sensitivity 0.365 0.142 0.376 0.118 0.004 0.139357136288 -0.44 NO G169C 5.77e-05 -3 [T[G>T]G] sensitivity 0.236 0.25 0.337 0.177 0.003 0.136559882965 2.89 NO T68S 7.68e-05 1 [A[A>T]C] sensitivity 0.225 0.266 0.409 0.1 -0.0 0.127879165355 -0.1 NO T68S 8.17e-05 1 [A[C>G]C] sensitivity 0.225 0.266 0.409 0.1 -0.0 0.127879165355 -0.1 NO E71G 0.0001519 -2 [G[A>G]G] sensitivity 0.249 0.224 0.312 0.215 -0.009 0.104605506436 1.77 NO V104I 0.001688 3 [A[G>A]T] sensitivity 0.145 0.331 0.438 0.087 -0.01 0.10144568643 0.57 NO Y113S 8.76e-05 -2 [T[A>C]C] sensitivity 0.336 0.151 0.373 0.14 -0.013 0.0950392949992 -0.31 NO L170R 0.0009976 -2 [C[T>G]G] sensitivity 0.238 0.23 0.326 0.206 -0.014 0.0907137646179 1.77 NO T63S 8.17e-05 1 [A[C>G]C] sensitivity 0.376 0.113 0.394 0.117 -0.018 0.0801288036717 -0.47 NO T63S 4.71e-05 1 [G[A>T]C] sensitivity 0.376 0.113 0.394 0.117 -0.018 0.0801288036717 -0.47 NO Q17K 0.000475 1 [G[C>A]A] sensitivity 0.261 0.213 0.413 0.112 -0.022 0.0697942330559 -0.66 NO L112V 0.0007641 1 [T[C>G]T] sensitivity 0.263 0.207 0.443 0.087 -0.031 0.047439928086 -0.31 NO V51I 0.001688 3 [A[G>A]T] sensitivity 0.154 0.303 0.46 0.083 -0.034 0.0389543746746 0.01 NO T110I 0.0004688 -1 [A[C>T]A] sensitivity 0.2 0.255 0.471 0.074 -0.043 0.016113151566 -0.39 NO L115R 0.0008952 -2 [C[T>G]C] sensitivity 0.304 0.14 0.326 0.23 -0.048 0.00162991035326 -0.44 NO Y64S 8.76e-05 -2 [T[A>C]C] sensitivity 0.289 0.163 0.412 0.136 -0.049 0.0 -0.52 NO K151* 4.94e-05 -4 [C[A>G]A] NO K151* 4.94e-05 -4 [C[A>G]A] NO R50* 0.094867 -4 [T[C>G]G] NO R50* 0.094867 -4 [T[C>G]G] NO K114* 4.94e-05 -4 [C[A>G]A] NO K114* 4.94e-05 -4 [C[A>G]A] NO K117* 5.15e-05 -4 [G[A>G]A] NO K117* 5.15e-05 -4 [G[A>G]A] NO Y64* 0.0005138 -4 [T[A>T]C] NO Y64* 0.0005138 -4 [T[A>T]C] NO Y64* 0.000217 -4 [T[A>T]C] NO Y64* 0.000217 -4 [T[A>T]C] NO Y113* 0.0005893 -4 [T[A>T]C] NO Y113* 0.0005893 -4 [T[A>T]C] NO Y113* 0.0001073 -4 [T[A>T]C] NO Y113* 0.0001073 -4 [T[A>T]C] NO R67* 7.62e-05 -4 [G[A>G]G] NO R67* 7.62e-05 -4 [G[A>G]G] NO G85* 5.77e-05 -4 [T[G>C]G] NO G85* 5.77e-05 -4 [T[G>C]G] NO S29* 0.0002472 -4 [C[T>G]C] NO S29* 0.0002472 -4 [C[T>G]C] NO C40* 0.0002262 -4 [T[G>T]C] NO C40* 0.0002262 -4 [T[G>T]C] NO L75* 0.0010661 -4 [C[T>G]T] NO L75* 0.0010661 -4 [C[T>G]T] NO L75* 4.4e-05 -4 [T[T>C]A] NO L75* 4.4e-05 -4 [T[T>C]A] NO E109* 0.0001909 -4 [G[G>C]A] NO E109* 0.0001909 -4 [G[G>C]A] NO E71* 0.0001909 -4 [G[G>C]A] NO E71* 0.0001909 -4 [G[G>C]A] NO K164* 4.94e-05 -4 [C[A>G]A] NO K164* 4.94e-05 -4 [C[A>G]A] NO C166* 0.0006446 -4 [T[G>T]T] NO C166* 0.0006446 -4 [T[G>T]T] NO Q105* 0.0004688 -4 [A[C>G]A] NO Q105* 0.0004688 -4 [A[C>G]A] NO Q17* 0.0003773 -4 [G[C>G]A] NO Q17* 0.0003773 -4 [G[C>G]A] NO K55* 5.15e-05 -4 [G[A>G]A] NO K55* 5.15e-05 -4 [G[A>G]A] NO Y30* 0.0005893 -4 [T[A>T]C] NO Y30* 0.0005893 -4 [T[A>T]C] NO Y30* 0.0001073 -4 [T[A>T]C] NO Y30* 0.0001073 -4 [T[A>T]C] NO Y36* 2.76e-05 -4 [T[A>T]C] NO Y36* 2.76e-05 -4 [T[A>T]C] NO Y36* 1.91e-05 -4 [T[A>T]C] NO Y36* 1.91e-05 -4 [T[A>T]C] NO K54* 4.94e-05 -4 [C[A>G]A] NO K54* 4.94e-05 -4 [C[A>G]A] NO E33* 0.0001423 -4 [C[G>C]A] NO E33* 0.0001423 -4 [C[G>C]A] NO C65* 0.0002341 -4 [T[G>T]C] NO C65* 0.0002341 -4 [T[G>T]C] NO