This PDF file includes:

• fig. S1. The original currents of Fig. 1.
  
• fig. S2. Characterization of ERG K⁺ currents by channel activator PD-118057 in acutely dissociated subthalamic neurons following similar experimental protocols and analyses of Fig. 1.
  
• fig. S3. The effect of PD-118057 on E-4031–sensitive currents.
  
• fig. S4. The effect of the ERG inhibitor and activator on spontaneous firing of subthalamic neurons in acute STN slices from parkinsonian rats.
  
• fig. S5. The distinct effects of the ERG inhibitor dofetilide on a pair of simultaneously recorded neurons, with one firing in the spontaneous tonic mode and the other in the burst mode.
  
• fig. S6. The effect of ERG channel inhibitor and activator on burst discharges in rat STN slices.
  
• fig. S7. The effect of ERG channel inhibitor and activator on the spontaneous firing activity of subthalamic neurons at low and high temperatures.
  
• fig. S8. Continuous recording of spontaneous firing activity in acute STN slices before, during, and after application of 5-μM E-4031 (A) or 0.5-μM PD-118057 (B).
  
• fig. S9. The effect of ERG channel inhibitor and activator on the plateau depolarization in the presence of tetrodotoxin.
  
• fig. S10. The effect of ERG channel modulation on rearing scores and the asymmetric limb use.
  
• fig. S11. Inhibition of ERG channels ameliorates abnormal burst discharges in parkinsonian rats.
  
• Methods for figs. S10 (E and F) and S11
  
• References (100, 101)

Download PDF