Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells

Supplemental Materials

This article contains the following supporting material:

  • Supplemental Materials
  • Video S1 - Supplementary Movie 1: Rac3 Biosensor time-lapse showing localized Rac3 activity during invadopodia activity. MDA-MB-231 cells expressing the Rac3 biosensor were plated on fluo-rescent matrix and imaged over 2hours. Movie corresponds to still frames from top panel of Fig-ure 7I. Insets show ring of Rac3 activity around actively degrading invadopodia.