Supplementary Table 16 - Aligned genomic promoter sequences of miR-215 of mouse (mmu), human (hsa) and macaque (mml). mmu-mir215 ------CGGTTTCCATCAGGGAAAACCCAGGCAGTGGGGCAGCTCTGACGGCAGCCAATC 54 hsa-mir215 ------ACCTTCATTTCTTTAACATTGTATACTTAACACAAACTCAT-AGTTAACCTATA 53 mml-mir215 AATTCTCCCTTTATTTCTTTAATATCCTATACTTAACACAAACTCAT-AGTTAACCTGTA 59 ** ** * * * * * *** * * ** * mmu-mir215 ACCCGGGCTCTGCTATCAGCAGCATGTGCTATTTAGCCGAGAAGCAGGAAGCACTCAGGA 114 hsa-mir215 ACCCAAAGATCAGTATA------AACGACTGCTGATAAAAGTGGGTGAAACCA------- 100 mml-mir215 ACCCAAAGATCAGTATA------AATGACTGCTAATAAAAGTGGGTGAAACCA------- 106 **** *** * ** * * ** * * ** ** mmu-mir215 CTTCCAGGTAAGGAGCC--GCTGCTGTCCTCTTGGTCCTCTGTTCTCTCTTTATAAGCAA 172 hsa-mir215 CTTACCAGTATGTAATCTATATGCTTCCATCTTAATGCTTTACTTCAT-----AAAGCAA 155 mml-mir215 CTTATCAGTATGTAATCTATATGCTTCCACCTTAGTGCTTTATTTCAT-----AAAGTAA 161 *** *** * * * **** * *** * ** * * * *** ** mmu-mir215 AAGGCACAGGACAGGATCTCTGCTGGAAGTGACCGTGGAAAGAACGAGGTAAGAGGCTAA 232 hsa-mir215 TAAATCCATCATAAAA--CCTTGTACTTTACTCAAAGGCCTTATCTCAACACATGCATTA 213 mml-mir215 TAAATCTATCATAAAA--CCTTGTACTTTACTCAAAGGCCTTATCTCAGCACAAGCATTA 219 * * * * * ** * * ** * * * * * * mmu-mir215 GAGTTCCTGTCTGTTGTCTAAATGTGACAAAGAACACGGTGGAGCTTCAGAAGGAAGAGC 292 hsa-mir215 CGTGTCCCTTCTTAGGTTTCAATCAGTGAAAATCCACTAGGTAGCATGAGCAACTATGAC 273 mml-mir215 TGTGTCCCTTCTTAGGTTTCAAACTGAGAAAATCCACTAGGTAGCATGAGCAACTATGAT 279 *** *** ** * ** * *** *** * *** * ** * * mmu-mir215 CTGTTCCCA------CCAAGT------------CCAATGCGCAGGCTGTAGAGGCAGCAG 334 hsa-mir215 ATCAGCCAATCATTCTGAACTTCGATATCAACCGGAATGAGGCTTATTTAGCGTGTTATG 333 mml-mir215 ACCAGCCAATCACTCTGAACTTCGATATCAACTGGAATGAGGCTTATTTAGCGTGTTACG 339 ** * ** * **** * * *** * * mmu-mir215 GCAACGATTTAGGATGC-TTTCTTTACTTACTGAACATAAAGTCCACAGGTTTCCAGAGG 393 hsa-mir215 G---ACATTAAGCAGCATTAAGATTACTAAAGCAACAAAGAAACGACTGCTGTCATCCCA 390 mml-mir215 G---ACATTAAGCAGCATTAAGATTACTAA-GCAACAAAGAAACTACGGCTGTCATCCCA 395 * *** ** * * ***** * **** * * * ** * * ** mmu-mir215 CTGGCT-------CTAAGCTACCTTAGCGCGTAAGTCAACAGTGCTGGTGACAACATACG 446 hsa-mir215 CTGTCTTCTGTGTTTTGCCTTTATAAGCAAAAATATTGAAGATTATTAAGACAACTTTTC 450 mml-mir215 CTGTCTTCTGTGTTTTGTCTTTATAAGCAAAAATATTAAGGATTATTAAGACAACTTTTC 455 *** ** * ** * *** * * * * * ****** * mmu-mir215 T---CTAAAATAAGGAAAG--AAACGCCATCAACAGCTTCCTGTCTTCTCTAGGTGGCCA 501 hsa-mir215 TTCTGTAACTTACTGGAAGAAGAATGAGGTAAGAGGCTAAATGTTTCACATTTG------ 504 mml-mir215 TTCTGTAACTTACTGGAAGAAGAATGAGGTAAGAGGCTAAATGTTTCACATTTG------ 509 * *** ** * *** ** * * * *** *** * * * mmu-mir215 ATGTTTCTAAATTTTATCCATTTTATGTTAAAAAATAC---TTGTTGCCAGGAAGTGGTG 558 hsa-mir215 ---TT--------TACTAAATTTAATTCTAGAACAATGTGAAATTTGGAAGGGGAAATTC 553 mml-mir215 ---TT--------TACTAAATTTAATTCTAGAACAAAGTTAAATTTGGGAGGGGAAATTC 558 ** * * **** ** ** ** * *** *** * mmu-mir215 GTTCACGCCTTTAATCCCAGCACTTGGGAGGCAGAGGTA---------------GG---T 600 hsa-mir215 TATTTTTAGTTTAATCCTAGATTTAT-GTTTTAAAGCTGACAGAAAACCATTTTGAAGAA 612 mml-mir215 TATTTTTAATTTAATCCTAGATTTAT-GTTTTAAAGGTGACAGAAAATCATTTTGGAGAA 617 * ******** ** * * * ** * * mmu-mir215 GGATTTCTGAGTTTGAGACCC----GCCTGGTCTACA--GAGTGAGTTCCAGGACAGCCA 654 hsa-mir215 ATTTTTCTTTATTTAATGAACATAAATTTTTTGAACAAAAGGTTTATTATTGTTAACTGA 672 mml-mir215 ATTTTTCTT----TAATGAACATAAATTTTTTGAACAAAAGGTTTATTATTGTTAATTGA 673 ***** * * * * * *** ** ** * * * mmu-mir215 GAGCTATACAGAGAAACCCTGTCTCCGAAAAAAAAAACAAAACAAAACTTGTTTTCATTA 714 hsa-mir215 GA----------AAAAATTTGAGGTAGCT---AAAGTTAACACTCAAATTATATTGGAAA 719 mml-mir215 GA----------AAAAAAATGAGGTAGCT---AAAGTTAACACTCAAATTATATTGGAAA 720 ** *** ** * *** ** ** ** ** * ** * mmu-mir215 ACCAGGGACTAG-ATTGCCACCTAAATTATACGGGGATTATATTACAGATTCAGGAAATG 773 hsa-mir215 TTCCTTGGCTATTTTTACTAAATTTCTCATAATTTCCAGAAGTTAGGGGCTAAGTTTCAC 779 mml-mir215 TTCCTTGGCTATTTTTACTAAATTTCTCATGATTTCCAGAAATTAGGGGCTAAGTTTCCC 780 * * *** ** * * * * ** * *** * * ** mmu-mir215 GCCAATGATATTAACATTAAAAGTTCTTGAGGAAAAGAAGCGAACATAAGCTATAAATGA 833 hsa-mir215 TATGTTAACTATAGCATTAATAGCATGAAAGTGATTATAACTGTTTGAAATGATGAAAGA 839 mml-mir215 TATGTTAATCATAGCATTAATAGCATGAAAGTGATTATAACTGTCTGAAATGATGAAAGA 840 * * ** ****** ** ** * * * ** ** ** ** mmu-mir215 AATTGACATGTCAGAGTTTGAGTC-CAGAGTTTAATTCTGTCAGTCTTTAAACTCATTTG 892 hsa-mir215 AATTTAACCAACTTCTTTTCCTTCCCAGGTAGCCAGTGTTTCTACATTTTATCTTTTTTA 899 mml-mir215 AATTTAACCAACTTCTTTTCCTTCCCAGGTAGCCAGTGTTTCTAAATTTTATCTGATTTA 900 **** * * *** ** *** * * * ** *** * ** *** mmu-mir215 GGACACGAGGAATCCCAGGTTCTCTTTGGGAAACAAGTAAGTATATTT-----AGAGGCA 947 hsa-mir215 TGCTAAAAATTATTTCTTCTGTTT--TTATTGACTAGTAACAGATTTCAACCCAAATTCT 957 mml-mir215 TGCTAAAAATTATTTCTTCTGTTT--TTATTGACTAGTAACAGATTTCAACCTAAATTCT 958 * * * ** * * * * ** ***** ** * * * mmu-mir215 ACTCGCAGACTCTCGTCCAGGAAGCAGAAAATCCAGGCGCGGCAGAGCTCACCGGGAATC 1007 hsa-mir215 AATGGCATTATCTCACAGATTCAAAAAATGACCAATGACAGTAAAGTCAGAAATGGAATT 1017 mml-mir215 AATGGCATTATATCACAGATTCAAAAAATGACCTATTTCAGTGAAGTCAGAAATTGAATT 1018 * * *** * ** * * * * * * * * * * * **** mmu-mir215 TCAGCTCCCTGGAAGCTGAGGCAGGACTGCAAGGTACAGGCTAGGTCTTGTCCCAAACTG 1067 hsa-mir215 ATTTCTTGATAAAATA--------------------CAAATATGATCTAAAATGCAAATG 1057 mml-mir215 ATTTCTTGAGAAAATA--------------------CAAATATGATCTAAAATGCAAATG 1058 ** ** ** * *** ** ** mmu-mir215 CCACCACTCCCACCACACACCAGGAAGA------GGTAGAGGGCTGGGGCTAGCTCCAGT 1121 hsa-mir215 ACACTATTAATTCAAATCAAAATAAAACATCAGCGTTTCAAATCTACCAGTCCCTA--AA 1115 mml-mir215 ACACTATTAATTCAAATCAAAATAAAACATCAGCATTTCAAATCTACCAGTCCCTA--AA 1116 *** * * * * ** * ** * * ** * ** mmu-mir215 CTCCTGTAGAGTACTTGCCTGGGATGCACCAGGCTCCAGGTTCAATCCTCAAGACTCCTC 1181 hsa-mir215 CTT--ATTTAGAACATGAATAAATCGAGACTTTCTTC--TGTGAAACAAGTATACTTAGA 1171 mml-mir215 CTG--ATTCAGAACATGAA----TGTTGACTTTCTTC--TGTGAAACAAGTATACTTAGA 1168 ** * ** ** ** * ** * * ** * * *** mmu-mir215 CACACCGAGGGAGTAGT-GTTTTAAAGCTAAGGACCCATCCGGCAAACTGATGGAGTCAT 1240 hsa-mir215 GATATCGTACAGCTCCCATGATGAGCAAAAGGAATCTCCTTATATGTTTAATGGTGTTAT 1231 mml-mir215 GATAATGTACAGATCCCATGATGAGCAAAAGGATTCTCCTTATATGTTTAATGGTGTTAT 1228 * * * * * * * * * * **** ** ** mmu-mir215 CGGGTGTAACAGCAACTCCATGTGGACTGTGCTCGGAT-TCCAGTGGAGCTGCTGTTACT 1299 hsa-mir215 CAAGTGTAACAGCAACTCCATGTGGACTGTGTACCAATTTCCAGTGGAGATGCTGTTACT 1291 mml-mir215 CAAGTGTAACAGCAACTCCATGTGGACTGTGTACCAATTTCCAGTGGAGATGCTGTTACT 1288 * **************************** * ** ********** ********** mmu-mir215 TCTGATGGCCTCCAACCGGCTACAAACATGGAAAAGGA--AGGGCAGACATTTCTGGGTG 1357 hsa-mir215 TTTGATGGTTACCAACTTGCTACAATATAAAGGTATAATAAAGAAAGACAGAAAATTGTG 1351 mml-mir215 TTTGATGGTTACCAACTTGACACAATATAAAGGTATAATAAAGAAAGACAGAAAATTGTG 1348 * ****** ***** * **** * * * * ***** *** mmu-mir215 GGCTC-TTGGTTATCATTTGATTCAGAAAAAGAAT---GATGATCTTCATTCTGTTTC-- 1411 hsa-mir215 GTCACTTGGACTCTCATTTGATTCCAGCAGAAAAAAAGATTTTC----AGCCTGTTTTAT 1407 mml-mir215 GTCACTTGGACTCTCATTTGATTCAGGTGGAAAAAAAGATAAACTTTCAGCCTGTTTTAC 1408 * * * * * * *********** * ** * ****** mmu-mir215 CTAACTAACAA----ATACTTAAGAATGTAAATGTTCTCAAGTTCAAGTGCTAGGTCAGC 1467 hsa-mir215 AAAATTAACAAATGATTAAGAATTAATATCAATTTTCTTAAATTCAAGTTTTGTAACACC 1467 mml-mir215 AAA-ATTAACAAGTAATAAGAATTAATATCAATTTTCTTAAATTCAAGTTTTGCAACACC 1467 * * * * ** * *** * *** **** ** ******* * ** * mmu-mir215 AGAGGACCCAGCCATGGAGACTACGGAGCACGG-- 1500 hsa-mir215 AAAAAGATCCAATAATG--GAAGAGGATTAAAGTC 1500 mml-mir215 AAAAAGATCCAATAATG--GAAGAGGATTAAAGTC 1500