Table S1. Genes that are upregulated during iron toxicity. Table S2. Genes that are downregulated during iron toxicity. Table S3. Bacterial strains and plasmids used in this study. Table S4. Primers and probes used in this study. Fig. S1. Schematic diagram showing the genetic context of pmtA in GAS genome (A) and insertional inactivation of pmtA by spectinomycin cassette (B). Fig. S2. Amino acid sequence alignment of PmtA and its orthologs from the genus Streptococcus. Fig. S3. Growth kinetics of the WT GAS and the isogenic ΔpmtA mutant strains in THY medium supplemented with increasing concentrations of indicated metals.
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