Number,Compound,SMILES,EZH2 WT (µM),EZH2 Y641N (µM),HeLa H3K27me3 (µM)
1 (CPI-169),524169,CC1=C(C(NCC2=C(OC)C=C(C)NC2=O)=O)C3=CC=CC=C3N1[C@H](C)C4CCN(S(=O)(CC)=O)CC4,<0.0010,0.0028,0.08
2,523825,O=C(NCC1=C(OC)C=C(C)NC1=O)C2=C(C)N([C@@H](C3CCNCC3)C)C4=CC=CC=C42,0.002,0.0039,1.1
3,524166,CC1=C(C(NCC2=C(OC)C=C(C)NC2=O)=O)C3=CC=CC=C3N1[C@H](C)C4CCN(C)CC4,<0.0010,0.0017,0.47
4,524160,CC1=C(C(NCC2=C(OC)C=C(C)NC2=O)=O)C3=CC=CC=C3N1[C@H](C)C4CCN(C(C(C)C)=O)CC4,0.0025,0.016,0.42
5,524170,CC1=C(C(NCC2=C(OC)C=C(C)NC2=O)=O)C3=CC=CC=C3N1[C@H](C)C4CCN(C(OC(C)C)=O)CC4,<0.0010,0.0041,0.11
6,589113,CC1=C(C(NCC2=C(OC)C=C(C)NC2=O)=O)C3=CC=CC=C3N1[C@@H](C4CCN(C(N(C)C)=O)CC4)C,0.0033,0.0089,0.93
7,524073,CC1=C(C(NCC2=C(OC)C=C(C)NC2=O)=O)C3=CC=CC=C3N1[C@H](C)C4CCN(C5COC5)CC4,<0.0010,0.0017,0.15
8,524370,CC1=C(C(NCC2=C(OC)C=C(C)NC2=O)=O)C3=CC=CC=C3N1[C@H](C)C4CCN(CC(OCC)=O)CC4,<0.0010,0.0025,0.26
9,529477,CC1=C(C(NCC2=C(OC)C=C(C)NC2=O)=O)C3=C(N1[C@@H](C4CCN(CCC(F)(F)F)CC4)C)C=CC=C3,0.0023,0.0048,0.29
10,590286,CC1=C(C(NCC2=C(OC)C=C(C)NC2=O)=O)C3=CC=CC=C3N1[C@H](C)C4CCN(CC(F)(F)C)CC4,<0.0010,<0.0010,0.02
11,591780,CC1=C(C(NCC2=C(OC)C=C(C)NC2=O)=O)C3=CC=CC=C3N1[C@H](C)C4CCN(CC(F)(F)C(F)F)CC4,0.0016,0.0033,0.038
12,524369,CC1=C(C(NCC2=C(OC)C=C(C)NC2=O)=O)C3=CC=CC=C3N1[C@H](C)C4CCN(CC(F)F)CC4,0.0018,0.0038,0.039
13 (CPI-1205),524416,CC1=C(C(NCC2=C(OC)C=C(C)NC2=O)=O)C3=CC=CC=C3N1[C@H](C)C4CCN(CC(F)(F)F)CC4,0.0022,0.0031,0.032