Table 4. Immunoreactive proteins identified by serological screen of vaccinia proteome microarrays
Reactive in immunized mice, humans, and macaques |
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Antigen |
PI |
Mol. Wt. |
Description |
TM Domain/ Sig. Peptide |
|
1 |
A10L |
6.33 |
102,283 |
Major core protein |
No/No |
2 |
A11R |
4.81 |
36,134 |
Hypothetical protein |
Yes/No |
3 |
A13L |
9.96 |
7.696 |
Structural protein |
Yes/Yes |
4 |
A33R |
5.3 |
20,506 |
EEV glycoprotein |
Yes/Yes |
5 |
A56R |
4.05 |
34,778 |
Hemagglutinin |
Yes/Yes |
6 |
B5R |
4.54 |
35,108 |
Plaque-size/host range protein |
Yes/Yes |
7 |
D8L |
9.55 |
35,326 |
Cell surface-binding protein |
Yes/No |
8 |
D13L |
5.10 |
61,890 |
Rifampicin resistance protein |
No/No |
9 |
F13L |
6.98 |
41,823 |
Major envelope protein |
No/No |
10 |
H3L |
6.43 |
37,458 |
IMV membrane protein |
Yes/No |
11 |
H5R |
7.55 |
22,270 |
Late transcription factor |
No/No |
Reactive in Immunized Humans & Macaques |
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1 |
A26L |
9.40 |
37,319 |
A-type inclusion protein |
No/No |
Reactive in Immunized Humans & Mice |
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1 |
A27L |
5.14 |
12,616 |
Cell fusion protein |
No/No |
2 |
E3L |
5.04 |
21,504 |
IFN resistance protein |
No/No |
3 |
L4R |
6.13 |
28,460 |
DNA-binding core protein |
No/No |
Reactive in Immunized Mice & Macaques |
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1 |
H7R |
7.27 |
16,912 |
Hypothetical protein |
No/No |
Reactive in Immunized Macaques Only |
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1 |
A17L |
4.28 |
22,999 |
IMV membrane protein |
Yes/Yes |
Reactive in Immunized Mice Only |
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1 |
A3L |
6.75 |
72,624 |
Major core protein |
No/No |
2 |
A4L |
4.68 |
30,846 |
Memb. associated core protein |
No/No |
3 |
D11L |
9.13 |
72,366 |
DNA helicase |
No/No |
4 |
H6R |
10.30 |
36,665 |
topoisomerase |
No/No |
5 |
K2L |
9.73 |
42,299 |
Serine protease inhibitor |
No/Yes |
6 |
N1L |
4.41 |
13,961 |
Hypothetical proteins |
No/No |
Reactive in Naïve (Non-immunized) Humans |
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1 |
A41L |
4.90 |
25,092 |
Secreted glycoprotein |
No/Yes |
2 |
A47L |
10.29 |
28,334 |
Hypothetical protein |
No/No |
3 |
B2R |
6.84 |
24,628 |
Hypothetical protein |
No/No |
4 |
D10R |
8.12 |
28,934 |
NTP-phosphohydrolase |
No/Yes |
5 |
E1L |
8.71 |
55,580 |
Poly(A) polymerase (VP55) |
No/No |
6 |
F2L |
8.64 |
16,264 |
dUTP pyrophosphatase |
No/No |
7 |
F9L |
6.72 |
23,792 |
Thioredoxin substrate |
Yes/Yes |
8 |
G5R |
4.93 |
49,872 |
Core/assembly protein |
No/No |
9 |
G7L |
7.72 |
41,920 |
Structural/core protein |
No/No |
10 |
H7R |
7.27 |
16,912 |
Hypothetical protein |
No/No |
11 |
I1L |
9,05 |
35,841 |
Telomere binding protein |
No/No |
12 |
L5R |
10.32 |
15,044 |
Myristylated protein |
Yes/No |
13 |
O2L |
5.27 |
12,355 |
glutaredoxin |
No/No |