This PDF file includes:

• fig. S1. Generation of obscurin knock-in mice carrying the R4344Q mutation in Ig58.
  
• fig. S2. Sarcomeric organization is unaltered in 1-year-old homozygous knock-in female mice.
  
• table S1. Morphometric and echocardiographic analyses of sedentary wild-type and homozygous knock-in hearts.
  
• table S2. Morphometric and echocardiographic analyses of sham- and TAC-subjected wild-type and knock-in hearts.
  
• table S3. NMR-derived restraints and statistics of 20 NMR structures of wild-type Ig58.
  
• table S4. Statistics of wild-type Ig58 crystal diffraction.
  
• table S5. List of primers used for confirmation of gene targeting, animal genotyping, and site-directed mutagenesis.

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