Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab

Supplemental Data

• Movie S1 (.avi, 6.0 MB) - Supplemental Movie S1. Overall structure of the FabXol3/IgE-Fc complex.
• Movie S2 (.avi, 8.0 MB) - Supplemental Movie S2. Conformational changes in IgE-Fc.
• Movie S3 (.avi, 5.6 MB) - Supplemental Movie S3. IgE-Fc is potentially conformationally flexible when in complex with FabXol3/omalizumab.
• Supplemental Data (.doc, 2.6 MB) - Supplemental Data