Supporting Information

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Fig. 5. Diagram showing the approach used to identify SRC-3 binding sites (Genpathway’s FactorPath Discovery method; Left). The Query method (Right) was used to confirm SRC-3 binding to the sites identified by the Discovery approach. The Query method also was used with anti-estrogen receptor a (ERa) immunoprecipitated chromatin to measure ERabinding. TranscriptionPath Query is carried out in an analogous fashion with an antibody against the large subunit of RNA polymerase II to measure ongoing transcription.