This PDF file includes:

• fig. S1. Purified DesAbs used in this study.
  
• fig. S2. BLI analysis of the interaction of different DesAbs with monomeric α-synuclein.
  
• fig. S3. Biotin-mediated affinity measurement of DesAb_3–9 binding to monomeric Aβ42 and setup of the experimental conditions.
  
• fig. S4. DesAb binding specificity assessment and interaction of DesAb_18–25 and DesAb_29–36 with the respective target peptides.
  
• fig. S5. A DesAb designed to target α-synuclein does not inhibit Aβ42 aggregation.
  
• fig. S6. Effect of the DesAbs on the global parameters k+kn and k+k2 of Aβ42 aggregation.
  
• fig. S7. Transduction of the fluorescent protein mCherry into wild-type worms.
  
• fig. S8. Effects of DesAb_18–25 and DesAb_29–36 treatments on the C. elegans worms.
  
• fig. S9. Fingerprints of the Aβ42 worms screened at day 4 of adulthood.
  
• fig. S10. Effects of DesAb_18–25 and DesAb_29–36 treatments on wild-type control worms.
  
• fig. S11. Analysis on the specificity of the treatment with the DesAbs in C. elegans.
  
• fig. S12. Effects of DesAb_18–25 and DesAb_29–36 treatments on the aggregation of Aβ42 in C. elegans models.
  
• fig. S13. Difference between the spectrum of DesAb_18–25 and the background.

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Other Supplementary Material for this manuscript includes the following:

• movie S1 (.avi format). Representative video clip of the Aβ42 C. elegans worms GMC101 at day 7 upon treatment with empty vesicles at days 1 and 3 (AP1, early treatment).
  
• movie S2 (.avi format). Representative video clip of the Aβ42 C. elegans worms GMC101 at day 7 upon treatment with empty vesicles at day 6 (AP2, late treatment).
  
• movie S3 (.avi format). Representative video clip of the control C. elegans worms N2 at day 7 upon treatment with empty vesicles at day 6 (AP2, late treatment).
  
• movie S4 (.avi format). Representative video clip of the Aβ42 C. elegans worms GMC101 at day 7 upon treatment with DesAb_18–25 at days 1 and 3 (AP1, early treatment).
  
• movie S5 (.avi format). Representative video clip of the Aβ42 C. elegans worms GMC101 at day 7 upon treatment with DesAb_29–36 at days 1 and 3 (AP1, early treatment).
  
• movie S6 (.avi format). Representative video clip of the Aβ42 C. elegans worms GMC101 at day 7 upon treatment with DesAb_18–25 at day 6 (AP2, late treatment).
  
• movie S7 (.avi format). Representative video clip of the Aβ42 C. elegans worms GMC101 at day 7 upon treatment with DesAb_29–36 at day 6 (AP2, late treatment).

Download Movies S1 to S7