Table 1. Genomic information of 70 genomes used in this study and their relatedness to the reference genomes
Group |
Strain |
Gen. Size |
Total CDSs |
Average nucleotide identity* |
Percent conserved genes † |
Enterics |
1.E. coli O157:H7 Sakai |
5.50 |
5,361 |
||
2.E. coli 0157:H7 EDL933 |
5.60 |
5,324 |
99.71,97.43,97.35 |
98.61,90.23,89.85 |
|
3.E. coli K12 |
4.60 |
4,279 |
97.21,97.95 |
72.91,88.15 |
|
4.E. coli CFT073 |
5.23 |
5,379 |
95.91,96.43,96.55 |
75.51,86.83,88.85 |
|
5.S. flexneri 2a 2457 |
4.60 |
4,068 |
96.51,97.53 |
69.61,82.63 |
|
6.S. flexneri 2a 301 |
4.61 |
4,180 |
96.41,97.53,99.85 |
69.51,82.33,995 |
|
7.S. typhimurium LT2 |
4.95 |
4,553 |
79.91,80.75 |
59.71,68.65 |
|
8.S. enterica ser. Typhi Ty2 |
4.79 |
4,323 |
80.21, |
571, |
|
9.S. enterica ser. Typhi |
4.80 |
4,767 |
80.21,99.98 |
57.71,99.68 |
|
10.S. bongori 12419 |
4.46 |
NA |
89.58 |
78.88 |
|
11.Y. pestis Kim |
4.60 |
4,090 |
71.51,71.65 |
371,45.15 |
|
12.Y. pestis CO92 |
4.65 |
4,083 |
71.51,99.911 |
37.21,99.711 |
|
13.Y. pestis Mediaevails |
4.6 |
4,142 |
99.8811 |
98.5611 |
|
14.Y. enterocolitica |
4.68 |
NA |
82.11 |
69.31 |
|
15.E. carotovora |
5.06 |
4,472 |
72.11 |
38.41 |
|
Pseudo- monas |
1.P putida KT2440 |
6.18 |
5,350 |
||
2.P aeruginosa PA01 |
6.30 |
5,567 |
75.1 |
56.2 |
|
3.P syringae DC3000 |
6.40 |
5,471 |
75.4 |
50.7 |
|
Neisseria |
1.N. meningitidis MC58 |
2.27 |
2,079 |
96.73 |
91.23 |
2.N. meningitidis FAM |
2.20 |
NA |
971,97.13 |
90.81,90.23 |
|
3.N. meningitidis Z2491 |
2.18 |
2,065 |
96.91 |
90.21 |
|
4.N. gonorrhoeae FA1090 |
2.15 |
NA |
94.31,94.33 |
82.41,82.73 |
|
Bord- etella |
1.B pertussis Tohama I |
4.09 |
3,447 |
96.62 |
72.12 |
2.B. bronchiceptica RB50 |
5.35 |
4,994 |
98.41 |
911 |
|
3.B. parapertussis |
4.77 |
4,185 |
98.21,98.32 |
87.91,87.22 |
|
Bacilli |
1.B cereus ATCC 14579 |
5.41 |
5,255 |
91.433 |
84.543 |
2.B cereus 10987 |
5.22 |
5,603 |
911,94.073 |
831,82.833 |
|
3.B anthracis Ames |
5.23 |
5,311 |
91.361 |
84.851 |
|
4.B cereus ZK |
5.3 |
5,134 |
91.341,97.053 |
84.051,90.63 |
|
Myco- bacteria |
1.M. tuberculosis CDC1551 |
4.40 |
4,187 |
||
2.M. tuberculosis h37Rv |
4.40 |
3,927 |
99.7 |
99.5 |
|
3.M. bovis |
4.35 |
3,920 |
99.4 |
98.3 |
|
4.M. avium |
5.48 |
NA |
79.1 |
62.6 |
|
Strep- tococci |
1.S. pyogenes SSI-1 |
1.89 |
1,861 |
97.92 |
92.72 |
2.S. pyogenes MGAS8232 |
1.90 |
1,845 |
97.81 |
92.51 |
|
3.S. pyogenes MGAS315 |
1.90 |
1,865 |
99.91,97.92 |
1001,92.72 |
|
4.S. pyogenes M1 GAS |
1.85 |
1,697 |
981,97.92,71.37 |
86.81,89.72,38.57 |
|
5.S. agalactiae 2603 |
2.20 |
2,124 |
74.51,74.42 |
56.21,56.52 |
|
6.S. agalactiae NEM |
2.21 |
2,094 |
98.55 |
87.55 |
|
7.S. pneumoniae r6 |
2.03 |
2,043 |
|||
8.S. pneumoniae TIGR4 |
2.20 |
2,094 |
71.41,71.32,98.47 |
41.31,42.12,95.97 |
|
9.S. mutans |
2.03 |
1,920 |
725 |
46.85 |
|
Staph-ylococci |
1.S aureus Mu50 |
2.90 |
2,748 |
98.23 |
93.53 |
2.S aureus N315 |
2.81 |
2,625 |
99.81,98.33 |
94.81,93.33 |
|
3.S aureus MW2 |
2.80 |
2,632 |
98.21 |
90.41 |
|
4.S aureus MSSR252 |
2.80 |
2,579 |
98.21,99.73 |
89.71,98.43 |
|
5.S aureus MRSA476 |
2.90 |
2,656 |
97.11,973 |
91.61,93.93 |
|
6.S. epidermitidis ATCC12228 |
2.50 |
2,419 |
|||
7.S. epidermitidis RP62A |
2.65 |
NA |
75.91,75.33,98.96 |
66.41,66.83,94.66 |
|
Others |
1.X. campestris ATCC33913 |
5.08 |
4,181 |
||
2.X. axonopodis pv. Citri 301 |
5.17 |
4,312 |
84.61 |
82.91 |
|
3.X. fastidiosa temecula |
2.52 |
2,036 |
|||
4.X. fastidiosa 9a5c |
2.68 |
2,832 |
95.73 |
95.83 |
|
5.Vibrio vulnificus CMCP6 |
5.13 |
4,514 |
|||
6.Vibrio vulnificus YJ016 |
5.21 |
5,024 |
97.915 |
89.55 |
|
7.H. pylori J99 |
1.64 |
1,491 |
|||
8.H. pylori 26695 |
1.66 |
1,576 |
957 |
93.37 |
|
9.B. melitensis 16M |
3.30 |
3,198 |
|||
10.B suis 1330 |
3.28 |
3,264 |
99.19 |
98.49 |
|
11.R. conorri |
1.27 |
1,374 |
|||
12.R. prowazekii |
1.10 |
835 |
87.711 |
59.411 |
|
13.C perfrigens 13 |
3.1 |
2,723 |
|||
14.C perfrigens ATCC13124 |
3.26 |
NA |
98.113 |
90.513 |
|
15.T. whipplei twist |
0.93 |
808 |
|||
16.T. whipplei TW08/27 |
0.93 |
783 |
99.215 |
99.315 |
|
17. B. pseudomallei |
7.25 |
5,729 |
|||
18. B. mallei |
5.84 |
4,764 |
98.6317 |
79.1117 |
|
19. L.pneumophila Philadelphia |
3.4 |
2,942 |
|||
20. L.pneumophila Paris |
3.64 |
3,166 |
96.6319 |
91.6419 |
|
21. L.pneumophila Lens |
3.41 |
2,934 |
96.4619 |
88.7219 |
The 70 strains used in this study (second column), their genome size (third column), and total CDSs in the genome (fourth column) are shown. Strains in bold were used as query genomes during the pairwise comparisons between strains of the same bacterial group (first column). The groups used are (from top to bottom): Enterics, Pseudomonas, Neisseria, Bordetella, Bacilli, Mycobacteria, Streptococcus, Staphylococcus, and Others. NA = not available, because the genome annotation has not been published.
*Average nucleotide identity of the conserved CDSs between the corresponding reference strain and the query strain, which is denoted by the superscript number.
†
Percent of query strain CDSs that are conserved in the corresponding reference strain.