Table 1. Genomic information of 70 genomes used in this study and their relatedness to the reference genomes

Group

Strain

Gen.

Size

Total

CDSs

Average nucleotide

identity*

Percent conserved

genes

Enterics

1.E. coli O157:H7 Sakai

5.50

5,361

   

2.E. coli 0157:H7 EDL933

5.60

5,324

99.71,97.43,97.35

98.61,90.23,89.85

3.E. coli K12

4.60

4,279

97.21,97.95

72.91,88.15

4.E. coli CFT073

5.23

5,379

95.91,96.43,96.55

75.51,86.83,88.85

5.S. flexneri 2a 2457

4.60

4,068

96.51,97.53

69.61,82.63

6.S. flexneri 2a 301

4.61

4,180

96.41,97.53,99.85

69.51,82.33,995

7.S. typhimurium LT2

4.95

4,553

79.91,80.75

59.71,68.65

8.S. enterica ser. Typhi Ty2

4.79

4,323

80.21,

571,

9.S. enterica ser. Typhi

4.80

4,767

80.21,99.98

57.71,99.68

10.S. bongori 12419

4.46

NA

89.58

78.88

11.Y. pestis Kim

4.60

4,090

71.51,71.65

371,45.15

12.Y. pestis CO92

4.65

4,083

71.51,99.911

37.21,99.711

13.Y. pestis Mediaevails

4.6

4,142

99.8811

98.5611

14.Y. enterocolitica

4.68

NA

82.11

69.31

15.E. carotovora

5.06

4,472

72.11

38.41

Pseudo-

monas

1.P putida KT2440

6.18

5,350

   

2.P aeruginosa PA01

6.30

5,567

75.1

56.2

3.P syringae DC3000

6.40

5,471

75.4

50.7

Neisseria

1.N. meningitidis MC58

2.27

2,079

96.73

91.23

2.N. meningitidis FAM

2.20

NA

971,97.13

90.81,90.23

3.N. meningitidis Z2491

2.18

2,065

96.91

90.21

4.N. gonorrhoeae FA1090

2.15

NA

94.31,94.33

82.41,82.73

Bord- etella

1.B pertussis Tohama I

4.09

3,447

96.62

72.12

2.B. bronchiceptica RB50

5.35

4,994

98.41

911

3.B. parapertussis

4.77

4,185

98.21,98.32

87.91,87.22

Bacilli

1.B cereus ATCC 14579

5.41

5,255

91.433

84.543

2.B cereus 10987

5.22

5,603

911,94.073

831,82.833

3.B anthracis Ames

5.23

5,311

91.361

84.851

4.B cereus ZK

5.3

5,134

91.341,97.053

84.051,90.63

Myco- bacteria

1.M. tuberculosis CDC1551

4.40

4,187

   

2.M. tuberculosis h37Rv

4.40

3,927

99.7

99.5

3.M. bovis

4.35

3,920

99.4

98.3

4.M. avium

5.48

NA

79.1

62.6

Strep- tococci

1.S. pyogenes SSI-1

1.89

1,861

97.92

92.72

2.S. pyogenes MGAS8232

1.90

1,845

97.81

92.51

3.S. pyogenes MGAS315

1.90

1,865

99.91,97.92

1001,92.72

4.S. pyogenes M1 GAS

1.85

1,697

981,97.92,71.37

86.81,89.72,38.57

5.S. agalactiae 2603

2.20

2,124

74.51,74.42

56.21,56.52

6.S. agalactiae NEM

2.21

2,094

98.55

87.55

7.S. pneumoniae r6

2.03

2,043

   

8.S. pneumoniae TIGR4

2.20

2,094

71.41,71.32,98.47

41.31,42.12,95.97

9.S. mutans

2.03

1,920

725

46.85

Staph-ylococci

1.S aureus Mu50

2.90

2,748

98.23

93.53

2.S aureus N315

2.81

2,625

99.81,98.33

94.81,93.33

3.S aureus MW2

2.80

2,632

98.21

90.41

4.S aureus MSSR252

2.80

2,579

98.21,99.73

89.71,98.43

5.S aureus MRSA476

2.90

2,656

97.11,973

91.61,93.93

6.S. epidermitidis ATCC12228

2.50

2,419

   

7.S. epidermitidis RP62A

2.65

NA

75.91,75.33,98.96

66.41,66.83,94.66

Others

1.X. campestris ATCC33913

5.08

4,181

   

2.X. axonopodis pv. Citri 301

5.17

4,312

84.61

82.91

3.X. fastidiosa temecula

2.52

2,036

   

4.X. fastidiosa 9a5c

2.68

2,832

95.73

95.83

5.Vibrio vulnificus CMCP6

5.13

4,514

   

6.Vibrio vulnificus YJ016

5.21

5,024

97.915

89.55

7.H. pylori J99

1.64

1,491

   

8.H. pylori 26695

1.66

1,576

957

93.37

9.B. melitensis 16M

3.30

3,198

   

10.B suis 1330

3.28

3,264

99.19

98.49

11.R. conorri

1.27

1,374

   

12.R. prowazekii

1.10

835

87.711

59.411

13.C perfrigens 13

3.1

2,723

   

14.C perfrigens ATCC13124

3.26

NA

98.113

90.513

15.T. whipplei twist

0.93

808

   

16.T. whipplei TW08/27

0.93

783

99.215

99.315

17. B. pseudomallei

7.25

5,729

   

18. B. mallei

5.84

4,764

98.6317

79.1117

19. L.pneumophila Philadelphia

3.4

2,942

   

20. L.pneumophila Paris

3.64

3,166

96.6319

91.6419

21. L.pneumophila Lens

3.41

2,934

96.4619

88.7219

The 70 strains used in this study (second column), their genome size (third column), and total CDSs in the genome (fourth column) are shown. Strains in bold were used as query genomes during the pairwise comparisons between strains of the same bacterial group (first column). The groups used are (from top to bottom): Enterics, Pseudomonas, Neisseria, Bordetella, Bacilli, Mycobacteria, Streptococcus, Staphylococcus, and Others. NA = not available, because the genome annotation has not been published.

*Average nucleotide identity of the conserved CDSs between the corresponding reference strain and the query strain, which is denoted by the superscript number.

Percent of query strain CDSs that are conserved in the corresponding reference strain.